For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
KFKPALVAAATAAAATAVALGGAATASADTEVQWLGQPGELVNGTVVQHWTVSHLKPSTDTIPYQPVGTL WEATASDEAVAGNVTPIISNLNARAKNGDTYRVLFGVATTQGVNPAPLAQGHKTSGKIYFDVTGEAPDSV FYSTGDAEELLWLQAPPPATGSGTSGSTSGSSSSGASSAPSAAAETTAPETPASTPAAEPAAVGSATPAS VPSGSSGTPLPEGSSGTPLPEGSSGTPLPEGSSGTPLPANAAPPAEAAPAPVPAAATPAPAAPTTTVAVP APPA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1515 | - | - | 100% (285) | FHA domain-containing protein |
| M. gilvum PYR-GCK | Mflv_2854 | - | 2e-20 | 41.67% (120) | hypothetical protein Mflv_2854 |
| M. gilvum PYR-GCK | Mflv_0760 | - | 4e-14 | 33.33% (195) | hypothetical protein Mflv_0760 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1961c | mpt63 | 4e-23 | 41.61% (149) | immunogenic protein MPT63 (antigen MPT63/MPB63) (16 KD |
| M. tuberculosis H37Rv | Rv1926c | mpt63 | 4e-23 | 41.61% (149) | immunogenic protein MPT63 (antigen MPT63/MPB63) (16 kDa |
| M. leprae Br4923 | MLBr_01556 | infB | 4e-05 | 29.94% (157) | translation initiation factor IF-2 |
| M. abscessus ATCC 19977 | MAB_1026c | - | 2e-68 | 51.79% (280) | hypothetical protein MAB_1026c |
| M. marinum M | MMAR_1823 | - | 1e-27 | 42.47% (146) | hypothetical protein MMAR_1823 |
| M. avium 104 | MAV_3737 | - | 6e-31 | 38.17% (186) | hypothetical protein MAV_3737 |
| M. smegmatis MC2 155 | MSMEG_0828 | - | 2e-60 | 47.17% (318) | immunogenic protein MPT63 |
| M. thermoresistible (build 8) | TH_4151 | - | 4e-22 | 38.51% (148) | PUTATIVE putative FHA domain containing protein |
| M. ulcerans Agy99 | MUL_2071 | - | 8e-21 | 41.13% (124) | hypothetical protein MUL_2071 |
| M. vanbaalenii PYR-1 | Mvan_5241 | - | 1e-108 | 66.33% (300) | FHA domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1515|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5241|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_1026c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_0828|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_1823|M.marinum_M --------------------------------------------------
MUL_2071|M.ulcerans_Agy99 --------------------------------------------------
MAV_3737|M.avium_104 --------------------------------------------------
Mb1961c|M.bovis_AF2122/97 --------------------------------------------------
Rv1926c|M.tuberculosis_H37Rv --------------------------------------------------
TH_4151|M.thermoresistible__bu --------------------------------------------------
MLBr_01556|M.leprae_Br4923 MAGKARVHELAKELGVTSKEVLARLNEQGEFVKSASSTVEAPVARRLRES
Mflv_1515|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5241|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_1026c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_0828|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_1823|M.marinum_M --------------------------------------------------
MUL_2071|M.ulcerans_Agy99 --------------------------------------------------
MAV_3737|M.avium_104 --------------------------------------------------
Mb1961c|M.bovis_AF2122/97 --------------------------------------------------
Rv1926c|M.tuberculosis_H37Rv --------------------------------------------------
TH_4151|M.thermoresistible__bu --------------------------------------------------
MLBr_01556|M.leprae_Br4923 FGGIKPAADKGAEQVATKAQAKRLGESLDQTLDRALDKAVAGNGATTAAP
Mflv_1515|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5241|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_1026c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_0828|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_1823|M.marinum_M --------------------------------------------------
MUL_2071|M.ulcerans_Agy99 --------------------------------------------------
MAV_3737|M.avium_104 --------------------------------------------------
Mb1961c|M.bovis_AF2122/97 --------------------------------------------------
Rv1926c|M.tuberculosis_H37Rv --------------------------------------------------
TH_4151|M.thermoresistible__bu --------------------------------------------------
MLBr_01556|M.leprae_Br4923 VQVDHSAAVVPIVAGEGPSTAHREELAPPAGQPSEQPGVPLPGQQGTPAA
Mflv_1515|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5241|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_1026c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_0828|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_1823|M.marinum_M --------------------------------------------------
MUL_2071|M.ulcerans_Agy99 --------------------------------------------------
MAV_3737|M.avium_104 --------------------------------------------------
Mb1961c|M.bovis_AF2122/97 --------------------------------------------------
Rv1926c|M.tuberculosis_H37Rv --------------------------------------------------
TH_4151|M.thermoresistible__bu --------------------------------------------------
MLBr_01556|M.leprae_Br4923 PHPGHPGMPTGPHPGPAPKPGGRPPRVGNNPFSSAQSVARPIPRPPAPRP
Mflv_1515|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5241|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_1026c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_0828|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_1823|M.marinum_M --------------------------------------------------
MUL_2071|M.ulcerans_Agy99 --------------------------------------------------
MAV_3737|M.avium_104 --------------------------------------------------
Mb1961c|M.bovis_AF2122/97 --------------------------------------------------
Rv1926c|M.tuberculosis_H37Rv --------------------------------------------------
TH_4151|M.thermoresistible__bu --------------------------------------------------
MLBr_01556|M.leprae_Br4923 SASPSSMSPRPGGAVGGGGPRPPRTGVPRPGGGRPGAPVGGRSDAGGGNY
Mflv_1515|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5241|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_1026c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_0828|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_1823|M.marinum_M --------------------------------------------------
MUL_2071|M.ulcerans_Agy99 --------------------------------------------------
MAV_3737|M.avium_104 --------------------------------------------------
Mb1961c|M.bovis_AF2122/97 --------------------------------------------------
Rv1926c|M.tuberculosis_H37Rv --------------------------------------------------
TH_4151|M.thermoresistible__bu --------------------------------------------------
MLBr_01556|M.leprae_Br4923 RGGGVGALPGGGSGGFRGRPGGGGHGGGGRPGQRGGAAGAFGRPGGAPRR
Mflv_1515|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5241|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_1026c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_0828|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_1823|M.marinum_M --------------------------------------------------
MUL_2071|M.ulcerans_Agy99 --------------------------------------------------
MAV_3737|M.avium_104 --------------------------------------------------
Mb1961c|M.bovis_AF2122/97 --------------------------------------------------
Rv1926c|M.tuberculosis_H37Rv --------------------------------------------------
TH_4151|M.thermoresistible__bu --------------------------------------------------
MLBr_01556|M.leprae_Br4923 GRKSKRQKRQEYDSMQAPVVGGVRLPHGNGETIRLARGASLSDFAEKIDA
Mflv_1515|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5241|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_1026c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_0828|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_1823|M.marinum_M --------------------------------------------------
MUL_2071|M.ulcerans_Agy99 --------------------------------------------------
MAV_3737|M.avium_104 --------------------------------------------------
Mb1961c|M.bovis_AF2122/97 --------------------------------------------------
Rv1926c|M.tuberculosis_H37Rv --------------------------------------------------
TH_4151|M.thermoresistible__bu --------------------------------------------------
MLBr_01556|M.leprae_Br4923 NPAALVQALFNLGEMVTATQSVGDETLELLGSEMNYNVQVVSPEDEDREL
Mflv_1515|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5241|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_1026c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_0828|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_1823|M.marinum_M --------------------------------------------------
MUL_2071|M.ulcerans_Agy99 --------------------------------------------------
MAV_3737|M.avium_104 --------------------------------------------------
Mb1961c|M.bovis_AF2122/97 --------------------------------------------------
Rv1926c|M.tuberculosis_H37Rv --------------------------------------------------
TH_4151|M.thermoresistible__bu --------------------------------------------------
MLBr_01556|M.leprae_Br4923 LEPFDLTYGEDQGDEDELQVRPPVVTVMGHVDHGKTRLLDTIRKANVREA
Mflv_1515|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5241|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_1026c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_0828|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_1823|M.marinum_M --------------------------------------------------
MUL_2071|M.ulcerans_Agy99 --------------------------------------------------
MAV_3737|M.avium_104 --------------------------------------------------
Mb1961c|M.bovis_AF2122/97 --------------------------------------------------
Rv1926c|M.tuberculosis_H37Rv --------------------------------------------------
TH_4151|M.thermoresistible__bu --------------------------------------------------
MLBr_01556|M.leprae_Br4923 EAGGITQHIGAYQVGVDLDGSERLITFIDTPGHEAFTAMRARGAKATDIA
Mflv_1515|M.gilvum_PYR-GCK ----------MKFKPALVAAATAAAAT-AVALGGAATASADTEVQW----
Mvan_5241|M.vanbaalenii_PYR-1 ----------MKFKPTVAAIITTAAAA-AVGVVGAGSASADAEVQY----
MAB_1026c|M.abscessus_ATCC_199 ----------MKIN-VPITAAVAAAAA-AAGLALMPTAGADTT-------
MSMEG_0828|M.smegmatis_MC2_155 ----------MKISQLTIAAAAALAISGAAGTAGMATAFAEAAQAAQVSA
MMAR_1823|M.marinum_M -----------------MKTAVGAAAIAAASVFGAASASAAPPTIQG---
MUL_2071|M.ulcerans_Agy99 ----------MEFIATTMKTAVGAAAIAAASVFGAASASAAPPTIQG---
MAV_3737|M.avium_104 ----------MKVTKNAVLTAAAAGGIAAASVFAATPAVAAP-NIQG---
Mb1961c|M.bovis_AF2122/97 ----------MKLT-TMIKTAVAVVAMAAIATFAAPVALAAYPITGK---
Rv1926c|M.tuberculosis_H37Rv ----------MKLT-TMIKTAVAVVAMAAIATFAAPVALAAYPITGK---
TH_4151|M.thermoresistible__bu ------------MNSKILAAPVVLATAAGLALATAAPAPARPGVAD----
MLBr_01556|M.leprae_Br4923 ILVVAADDGVMPQTVEAINHAQAADVPIVVAVNKIDKEGADPAKIRGQLT
. *
Mflv_1515|M.gilvum_PYR-GCK --------LGQPGELVN-----GTVVQHWTVSHLKPSTDTIP-YQPVGTL
Mvan_5241|M.vanbaalenii_PYR-1 --------LGQPGELVN-----GSVIQHWTVTGLKPSSDVIP-YRPVGTL
MAB_1026c|M.abscessus_ATCC_199 --------LGQQGRLTN-----GDVVQAWTISDLKVSTDQLP-YQPKGTL
MSMEG_0828|M.smegmatis_MC2_155 NP------LGSQARLEN-----GDVVQAWTISDLKPSSDPIP-YAVQGTL
MMAR_1823|M.marinum_M --------FGTSERLVD-----GPMVTSYTVGNLQLSDVTIAGYLPQGQL
MUL_2071|M.ulcerans_Agy99 --------FGTSERLVD-----GPMVTSYTVGNLQLSDVTIAGYLPQGQL
MAV_3737|M.avium_104 --------FGVSEQLVD-----GPLVTDYTVSNLQPSNVSIPGYTPKGTL
Mb1961c|M.bovis_AF2122/97 --------LGSELTMTDT---VGQVVLGWKVSDLKSSTAVIPGYPVAGQV
Rv1926c|M.tuberculosis_H37Rv --------LGSELTMTDT---VGQVVLGWKVSDLKSSTAVIPGYPVAGQV
TH_4151|M.thermoresistible__bu --------FGATQHLHD-----GGVTIAYTLEELEPSDDVVSNVALQGRL
MLBr_01556|M.leprae_Br4923 EYGLVAEDFGGDTMFIDISAKVGTNIEALLEAVLLTADAALDLRANSGME
:* : : * * : : *
Mflv_1515|M.gilvum_PYR-GCK WEATASDEAVAGNVTPIISNLNAR--------AKNGDTYRVLFGVATTQG
Mvan_5241|M.vanbaalenii_PYR-1 WEATATDEAIAGTVTPIVSNLNAR--------AENGDTYRVLFGVATEQG
MAB_1026c|M.abscessus_ATCC_199 WEATATDEAIQGSVIPIVANFNAK--------ANDGETYRVLYGVASAQG
MSMEG_0828|M.smegmatis_MC2_155 WEATATDEAVSGSVIPIVSNLNAR--------AANGENYRVLFQVATPQG
MMAR_1823|M.marinum_M YSADVTARSVTGTITPLVSSFNAR--------AANGDTYGVVNEVPAPGG
MUL_2071|M.ulcerans_Agy99 YSADVTGRSVTGTITPLVSSFSAR--------AANGDTYGVVNEVPAPGG
MAV_3737|M.avium_104 YQADISVRSDGGVVTPMVHDFIAR--------GPNGQNYRVIDNVAVPNG
Mb1961c|M.bovis_AF2122/97 WEATATVNAIRGSVTPAVSQFNAR--------TADGINYRVLWQAAGPDT
Rv1926c|M.tuberculosis_H37Rv WEATATVNAIRGSVTPAVSQFNAR--------TADGINYRVLWQAAGPDT
TH_4151|M.thermoresistible__bu WEVSVTVEAVEGAATPVIPFFNAR--------SADGQNYRALFTAVGEEA
MLBr_01556|M.leprae_Br4923 AQGVAIEAHLDRGRGPVATVLVQRGTLRIGDSVVAGDAYGRVRRMVDEHG
. * : : * * :
Mflv_1515|M.gilvum_PYR-GCK VNPAPLAQGHKTSGKIYFDVTGEAPDSVFYSTGDAEELLWLQAPPPATGS
Mvan_5241|M.vanbaalenii_PYR-1 VNPSTLAQGQKTTGKIYFDVTGQQPDSVFYSDGGSEVLLWLEAPP-APAT
MAB_1026c|M.abscessus_ATCC_199 VNPGTLSQGEKTTGKIYFDVTGANPETVTYTSGDEDLLTWKAAPAAAPAQ
MSMEG_0828|M.smegmatis_MC2_155 VNPSTLAPGQKTTGKVYFDVTGEAPTTVVYNDGERDLLAWSQTAASTTSP
MMAR_1823|M.marinum_M LNPAPILQGNSQSGVLYFDVTGPPPNGVVYNDGVQDVLIWTSNV------
MUL_2071|M.ulcerans_Agy99 LNPAPILQGNSQSGVLYF--------------------------------
MAV_3737|M.avium_104 LSPAPIPQGTESTGTLYFDVTGAPPNGVVYNDGMQDVLMWTSNVPSSAPG
Mb1961c|M.bovis_AF2122/97 ISGATIPQGEQSTGKIYFDVTGPSPTIVAMNNGMEDLLIWEP--------
Rv1926c|M.tuberculosis_H37Rv ISGATIPQGEQSTGKIYFDVTGPSPTIVAMNNGMEDLLIWEP--------
TH_4151|M.thermoresistible__bu LSGATLGQGQETEGNIYFDVTGAPPTEVVYNDAVQDRLIWR---------
MLBr_01556|M.leprae_Br4923 VDIEAALPSSPVQVIGFTSVPGAGDNFLVVDEDRIARQIADRRSARKRNA
:. . . :
Mflv_1515|M.gilvum_PYR-GCK GTSGSTSGSSSSGASSAP--SAAAETTAP-ETPAS---------------
Mvan_5241|M.vanbaalenii_PYR-1 GSAG--SGASGYGSEASP--SAAADTATP-ETPGT---------------
MAB_1026c|M.abscessus_ATCC_199 RSGGS-TQSHGSTPAPAT--STAPTTATP-APAAVPAGSQGTPLPAGSQG
MSMEG_0828|M.smegmatis_MC2_155 RPAATGSGTSASTPARTAPVTTAPASNTP-ATELVPESPAVAPTGAAPAA
MMAR_1823|M.marinum_M --------------------------------------------------
MUL_2071|M.ulcerans_Agy99 --------------------------------------------------
MAV_3737|M.avium_104 APNSPAPGAPNSPAPGAP---PAPAAHT----------------------
Mb1961c|M.bovis_AF2122/97 --------------------------------------------------
Rv1926c|M.tuberculosis_H37Rv --------------------------------------------------
TH_4151|M.thermoresistible__bu --------------------------------------------------
MLBr_01556|M.leprae_Br4923 LAARSRKRISLEDLDSALKETSQLNLILKGDNAGTVEALEEALMGIQVDD
Mflv_1515|M.gilvum_PYR-GCK TPAAEPAAVGSATPASVPSGSSGT----------PLPE----------GS
Mvan_5241|M.vanbaalenii_PYR-1 TPAAETPTSVVPTPVAAPAGSSGT----------PLPE----------GS
MAB_1026c|M.abscessus_ATCC_199 TPVDEQAPAATPTPTVAPVTATPT----------PAPATPTP------GA
MSMEG_0828|M.smegmatis_MC2_155 APGAGAAATDIPGSTVPPLAEDAADEALAEELTEDLPDELSQDSVTPGES
MMAR_1823|M.marinum_M --------------------------------------------------
MUL_2071|M.ulcerans_Agy99 --------------------------------------------------
MAV_3737|M.avium_104 --------------------------------------------------
Mb1961c|M.bovis_AF2122/97 --------------------------------------------------
Rv1926c|M.tuberculosis_H37Rv --------------------------------------------------
TH_4151|M.thermoresistible__bu --------------------------------------------------
MLBr_01556|M.leprae_Br4923 EVALRVIDRGVGGITETNVNLASASDAIIIGFNVRAEGKATELASREGVE
Mflv_1515|M.gilvum_PYR-GCK SGTPLP---EGSSGTPLPEGSS-----GTPLPANAAPPAEAAP-APVPAA
Mvan_5241|M.vanbaalenii_PYR-1 SGTPLP---EGSSGTPLPAGAAPVEAGPAPVPAGVAPAPHGSSGTPLPAG
MAB_1026c|M.abscessus_ATCC_199 EGTPLNS--TAVPASPAPATATP----AVPVPEGAAPQTGTPPVAAVPGV
MSMEG_0828|M.smegmatis_MC2_155 VGTPLPAAVQQAPAAPAPGQPAPAAPGAQDIPAAPAGEVPAAPVTPAPAA
MMAR_1823|M.marinum_M --------------------------------------------------
MUL_2071|M.ulcerans_Agy99 --------------------------------------------------
MAV_3737|M.avium_104 --------------------------------------------------
Mb1961c|M.bovis_AF2122/97 --------------------------------------------------
Rv1926c|M.tuberculosis_H37Rv --------------------------------------------------
TH_4151|M.thermoresistible__bu --------------------------------------------------
MLBr_01556|M.leprae_Br4923 IRYYLVIYQAIDDIEKALRGMLKPIYEENQLGRAEIRALFRSSKVGIIAG
Mflv_1515|M.gilvum_PYR-GCK A--------TPAPAAPTTTVA-----VPAPPA------------------
Mvan_5241|M.vanbaalenii_PYR-1 APAVEGVQPAPAPGAPTTTVV-----VPAPPA------------------
MAB_1026c|M.abscessus_ATCC_199 P-AVPASDSVPHGQRAAGSQG-----TPVSTEG-----------------
MSMEG_0828|M.smegmatis_MC2_155 PVDGSTTPTVPAGSDAPLTAGGIPTLVPAANPGAPTP-------------
MMAR_1823|M.marinum_M --------------------------------------------------
MUL_2071|M.ulcerans_Agy99 --------------------------------------------------
MAV_3737|M.avium_104 --------------------------------------------------
Mb1961c|M.bovis_AF2122/97 --------------------------------------------------
Rv1926c|M.tuberculosis_H37Rv --------------------------------------------------
TH_4151|M.thermoresistible__bu --------------------------------------------------
MLBr_01556|M.leprae_Br4923 CIISSGVVRRNAKVRLLRDNIVVTDNLTVTSLRREKDDVTEVREGFECGM
Mflv_1515|M.gilvum_PYR-GCK ------------------------
Mvan_5241|M.vanbaalenii_PYR-1 ------------------------
MAB_1026c|M.abscessus_ATCC_199 ------------------------
MSMEG_0828|M.smegmatis_MC2_155 ------------------------
MMAR_1823|M.marinum_M ------------------------
MUL_2071|M.ulcerans_Agy99 ------------------------
MAV_3737|M.avium_104 ------------------------
Mb1961c|M.bovis_AF2122/97 ------------------------
Rv1926c|M.tuberculosis_H37Rv ------------------------
TH_4151|M.thermoresistible__bu ------------------------
MLBr_01556|M.leprae_Br4923 TLGYSDIKEGDVIESYELVEKQRA