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GLLSRKVGDLRIYLGAAPGVGKTYSMLAEAHRRMERGTDVVAAMVDTHGRRKVGQLLASIDVIPPLIVEH EGTEYQEIDVPALLMRRPKVVLVDDLAHTNAPGSRNPKRWQDVEELLNAGITVISTVNIQNLESVADLAG QITGVDEPDRIPDEVVRAADQIELVDITPEALRRRLAHGNIYPRERVDAALSNYFRPENLTALRQLALLW LADQVDAALEKYRSANKIPDTWKPRERVVVGVTGGPGSETQVRRASLIASRTGADLKVVHVVRGDGLTVT SAQQKRVLRDLAASLGATLHTVIGDDVAATLIDFARDVNATQLVVGTSRRSRLARFFDEGITATVVQRSG PLDVHVVTHEEAGTGISKPRVGPGASVTGWLAAVALPPAICALLLAVPPLGVGTQTALFVAGVLMIALLG GIARAALSAVLSGVLITYFLIEPRNSFAVAGADSALTTGVLLGLAIAVAGLVDQTARHSRAARRASQNAE LLALFADGVLRDADPGALLERVRETYAQRSVSLLRGRTGEVLAHAGANPCTDIDEADTTIEIGDDEYWLL LAGPDLTSHDRRVLNAVAEQAVSLVKKRRQADEAIKFDTEAEKLRSSIQSAITHNLRTPLVTAKAAIAGA AHDNPPPDDTVELLAAAEKSVDELSVLVVNLLDSSCLATGAIRPELRPVDLRDAVEHVLRDIGPDARRVH VDVDGTPVLADGELLGRVLGNLLTNSLRYGDPDGDSAGDSGVVRVTAGQVDDRVLIAVVDSGPGIPRGSE HEAFAPFQRLGRDDANIGVGLGLPVASGLVEAMGGKISMTETPGGGLTVEIDLPAARRSE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5372 | - | - | 100% (831) | sensor protein KdpD |
| M. smegmatis MC2 155 | MSMEG_5395 | - | 0.0 | 60.74% (838) | sensor protein KdpD |
| M. smegmatis MC2 155 | MSMEG_5487 | - | 5e-21 | 31.33% (316) | sensor histidine kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1056c | kdpD | 0.0 | 60.57% (842) | sensor protein KDPD |
| M. gilvum PYR-GCK | Mflv_1582 | - | 5e-20 | 32.21% (326) | integral membrane sensor signal transduction histidine kinase |
| M. tuberculosis H37Rv | Rv1028c | kdpD | 0.0 | 60.57% (842) | sensor protein KDPD |
| M. leprae Br4923 | MLBr_00175 | - | 2e-14 | 28.12% (313) | putative two-component system sensor kinase |
| M. abscessus ATCC 19977 | MAB_3251c | - | 0.0 | 52.95% (831) | sensor protein KdpD |
| M. marinum M | MMAR_0634 | kdpD | 0.0 | 61.12% (841) | two-component system response phosphate sensor kinase, KdpD |
| M. avium 104 | MAV_1170 | - | 0.0 | 58.28% (851) | sensor protein KdpD |
| M. thermoresistible (build 8) | TH_4550 | - | 8e-23 | 35.32% (218) | PUTATIVE putative integral membrane sensor signal transduction |
| M. ulcerans Agy99 | MUL_0464 | phoR | 3e-18 | 32.93% (246) | two component system response phosphate sensor kinase, PhoR |
| M. vanbaalenii PYR-1 | Mvan_4762 | - | 0.0 | 60.83% (845) | osmosensitive K+ channel signal transduction histidine kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1056c|M.bovis_AF2122/97 MTLLFADLCAIFTPYRWMIEHVTTKRGQLRIYLGAAPGVGKTYAMLGEAH
Rv1028c|M.tuberculosis_H37Rv MTLLFADLCAIFTPYRWMIEHVTTKRGQLRIYLGAAPGVGKTYAMLGEAH
MAV_1170|M.avium_104 ----MTDVRDHHP-----------KRGELRIYLGAAPGVGKTYSMLGEAH
MMAR_0634|M.marinum_M -------MTPDYP----------RKRGELRIYLGAAPGVGKTFAMLGEAQ
Mvan_4762|M.vanbaalenii_PYR-1 ----MDDESVAASP-------HKAKRGELRIYLGAAPGVGKTYAMLGEAH
MAB_3251c|M.abscessus_ATCC_199 -------MPDGLR-----------ARGTLRIYLGAAPGVGKTFAMLNEAH
MSMEG_5372|M.smegmatis_MC2_155 -------MGLLSR-----------KVGDLRIYLGAAPGVGKTYSMLAEAH
Mflv_1582|M.gilvum_PYR-GCK --------------------------------------------------
MUL_0464|M.ulcerans_Agy99 --------------------------------------------------
TH_4550|M.thermoresistible__bu --------------------------------------------------
MLBr_00175|M.leprae_Br4923 --------------------------------------------------
Mb1056c|M.bovis_AF2122/97 RRLERGTDVVAAVVETHGRNKTAKLLEGIEMIPPRYVEYRGARFPELDVE
Rv1028c|M.tuberculosis_H37Rv RRLERGTDVVAAVVETHGRNKTAKLLEGIEMIPPRYVEYRGARFPELDVE
MAV_1170|M.avium_104 RRLERGTDLVAGVVETHGRAKTAELLEGIEIIPPRYIEYRGGRFPELDVP
MMAR_0634|M.marinum_M RRLERGTDVVAAVVETHGRKRTAELLEGIERIPPKFIEYRGSRFAELDVE
Mvan_4762|M.vanbaalenii_PYR-1 RRLERGTDVVAAVVETHGRKKTAELFEGIEIVPPKLIAYRGSDFAELDVE
MAB_3251c|M.abscessus_ATCC_199 RRAGRGTDVVAAVVETHGRSKTAELLDGLELIPPKEMVHRGTAMYELDVD
MSMEG_5372|M.smegmatis_MC2_155 RRMERGTDVVAAMVDTHGRRKVGQLLASIDVIPPLIVEHEGTEYQEIDVP
Mflv_1582|M.gilvum_PYR-GCK --------------------------------------------------
MUL_0464|M.ulcerans_Agy99 --------------------------------------------------
TH_4550|M.thermoresistible__bu --------------------------------------------------
MLBr_00175|M.leprae_Br4923 --------------------------------------------------
Mb1056c|M.bovis_AF2122/97 AVLRRHPQVVLVDELAHTNTPGSKNPKRWQDVQEILDAGITVISTVNIQH
Rv1028c|M.tuberculosis_H37Rv AVLRRHPQVVLVDELAHTNTPGSKNPKRWQDVQEILDAGITVISTVNIQH
MAV_1170|M.avium_104 AVLARHPQVVLVDELAHTNTPGSKNPKRWQDVEELLDAGITVISTVNVQH
MMAR_0634|M.marinum_M AVLRRQPQVVLVDELAHTNTPGSKNPKRWQDVEELLDAGITVISTVNVQH
Mvan_4762|M.vanbaalenii_PYR-1 AVLRRNPQVVLVDELAHTNTPGSKNTKRWQDIEELLDAGITVITTVNVQH
MAB_3251c|M.abscessus_ATCC_199 AVLERRPALVLIDEMAHTNVPGSRNPKRWQDIDEILDAGIDVLTTINVQH
MSMEG_5372|M.smegmatis_MC2_155 ALLMRRPKVVLVDDLAHTNAPGSRNPKRWQDVEELLNAGITVISTVNIQN
Mflv_1582|M.gilvum_PYR-GCK --------------------------------------------------
MUL_0464|M.ulcerans_Agy99 --------------------------------------------------
TH_4550|M.thermoresistible__bu --------------------------------------------------
MLBr_00175|M.leprae_Br4923 --------------------------------------------------
Mb1056c|M.bovis_AF2122/97 LEGLNDVVEQITGIEQKEKIPDEIVRAADQVELVDITPEALRRRLAHGNV
Rv1028c|M.tuberculosis_H37Rv LEGLNDVVEQITGIEQKEKIPDEIVRAADQVELVDITPEALRRRLAHGNV
MAV_1170|M.avium_104 LESLNDVVAQITGIEQKETVPDSVVRQASQVELIDITPEALRRRLSHGNV
MMAR_0634|M.marinum_M LESLNDVVAQITGIEQQEKVPDEIVRAAEQVELVDITPEALRRRLAHGNV
Mvan_4762|M.vanbaalenii_PYR-1 LESLNDVVTQITGIEQQEKVPDEVVRAADQVELVDITPEALRRRLAHGNV
MAB_3251c|M.abscessus_ATCC_199 LESLNDVVEQITGIVQRETVPDAVVRRAEQVELVDITPEALRRRMVHGNV
MSMEG_5372|M.smegmatis_MC2_155 LESVADLAGQITGVDEPDRIPDEVVRAADQIELVDITPEALRRRLAHGNI
Mflv_1582|M.gilvum_PYR-GCK -----------------MSSASPDERSNLNNGDVAGRRRYLRRGVPLRVA
MUL_0464|M.ulcerans_Agy99 ---------------------------------MAER---LPRAVQLRVG
TH_4550|M.thermoresistible__bu --------------------------------------VSLRGRITIMSA
MLBr_00175|M.leprae_Br4923 -----------------------------MVRFAWRRRASLRATSSLSLR
*
Mb1056c|M.bovis_AF2122/97 YAAERVDAALSNYFRTGNLTALREIALLWLADQVDAALEKYRADKKITAT
Rv1028c|M.tuberculosis_H37Rv YAAERVDAALSNYFRTGNLTALREIALLWLADQVDAALEKYRADKKITAT
MAV_1170|M.avium_104 YAPDRIDAALSNYFRRGNLTALRELALLWLADQVDTALAKYRAENKITDT
MMAR_0634|M.marinum_M YAAERVDAALANYFRTGNLTALRELALLWLADQVDAALEKYRADKKITAT
Mvan_4762|M.vanbaalenii_PYR-1 YAPERVDAALSNYFRRGNLTALRELALLWLADQVDSALEKYRADNKITDT
MAB_3251c|M.abscessus_ATCC_199 YAPEKVGSALSNYFRTGNLTALRELALLWLADQVDAALAKYRSDNRITKT
MSMEG_5372|M.smegmatis_MC2_155 YPRERVDAALSNYFRPENLTALRQLALLWLADQVDAALEKYRSANKIPDT
Mflv_1582|M.gilvum_PYR-GCK LVAATLLLVACGLLASG--IAVTTIMQHSLMNRVDDTLLDASRGWAQVPR
MUL_0464|M.ulcerans_Agy99 LVAATLALVLCGLLASG--VAVTSILRHSLVSRIDSTLLEASRTWAQASW
TH_4550|M.thermoresistible__bu AVS----------------CAAAALLLAITYALVDLQLSRRGP----VVM
MLBr_00175|M.leprae_Br4923 WRVMLLAMSMVAMVVVLMAFAVYVVISAALYSDIDNQLQSRAQLLIASGS
* : :* *
Mb1056c|M.bovis_AF2122/97 WEARERVVVAVTGGPESETLVRRASRIASKSSAELMVVHVIRGDDLAGVS
Rv1028c|M.tuberculosis_H37Rv WEARERVVVAVTGGPESETLVRRASRIASKSSAELMVVHVIRGDGLAGVS
MAV_1170|M.avium_104 WEARERVVVAVTGGPESETLVRRASRIASKSSAELMVVHVIRGDGLAGLS
MMAR_0634|M.marinum_M WEARERVVVAVTGGPESETLVRRAFRIASKASAELMVVHLARGDGLSGVA
Mvan_4762|M.vanbaalenii_PYR-1 WEARERVVVAVTGGPESETLVRRASRIASKSSAELMVVHVVQGDGLSGVS
MAB_3251c|M.abscessus_ATCC_199 WEARERVVVAVTGGPESETLVRRASRIAAKSSAELLVVHVVRGDGLVGAS
MSMEG_5372|M.smegmatis_MC2_155 WKPRERVVVGVTGGPGSETQVRRASLIASRTGADLKVVHVVRGDGLTVTS
Mflv_1582|M.gilvum_PYR-GCK RLPTITVDDPNPARPPSDFYVR----------------------------
MUL_0464|M.ulcerans_Agy99 RHSMPSVEGPDPARPPSKFYVR----------------------------
TH_4550|M.thermoresistible__bu RRSPPDTAPAEPTGPEVS--------------------------------
MLBr_00175|M.leprae_Br4923 LAADPGKAIEGTAYSDVNAMLVN---------------------------
. . . .
Mb1056c|M.bovis_AF2122/97 APQLGRVRELATSLGATMHTVVGD---DVPTALLDFAREMNATQLVVGTS
Rv1028c|M.tuberculosis_H37Rv APQLGRVRELATSLGATMHTVVGD---DVPTALLDFAREMNATQLVVGTS
MAV_1170|M.avium_104 ESRMAKIRELASSLDASLHTIVGD---EVPAALLEFAREMNATQLVIGTS
MMAR_0634|M.marinum_M APQMGKVRELAASLGATVHTVVGD---DVPTALLDFAREMNATQLVLGTS
Mvan_4762|M.vanbaalenii_PYR-1 GPQMGKVRELAASIGATLHTVVGDGAGGVPAALLDFAREMNATQLVLGTS
MAB_3251c|M.abscessus_ATCC_199 TAVMTRVRRLANDIGASVQAVTGD---DVPQTLLDFARGVNATQLVLGTS
MSMEG_5372|M.smegmatis_MC2_155 AQQKRVLRDLAASLGATLHTVIGD---DVAATLIDFARDVNATQLVVGTS
Mflv_1582|M.gilvum_PYR-GCK ----------GIDPDGHVWMLIND--------------------------
MUL_0464|M.ulcerans_Agy99 ----------SISPDGRAMTAIND--------------------------
TH_4550|M.thermoresistible__bu --------------------------------------------------
MLBr_00175|M.leprae_Br4923 -------------PGHSIYTANQP--------------------------
Mb1056c|M.bovis_AF2122/97 RRSRWARLFDEGIGARTVQESGGIDVHMVTHPAASRASGWSRVSP--RER
Rv1028c|M.tuberculosis_H37Rv RRSRWARLFDEGIGARTVQEPGGIDVHMVTHPAASRASGWSRVSP--RER
MAV_1170|M.avium_104 RRSRWARLFEEGIGPRIVELSGKIDVHLVTHEESKRGFRASSLAP--RER
MMAR_0634|M.marinum_M RRSRWARVLDEGIGATVVQQSGPIDVHMVTHQEAGRPARWSWLWP--REH
Mvan_4762|M.vanbaalenii_PYR-1 RRSRWARIFDEGIGATVVQKSGRIDVHMVTHEQAGGESLWARVSP--RQR
MAB_3251c|M.abscessus_ATCC_199 RRSRWARILDEGVAAAVIRDSGAIDVHMVTHGHTSGRLRSWSVPQDGRKR
MSMEG_5372|M.smegmatis_MC2_155 RRSRLARFFDEGITATVVQRSGPLDVHVVTHEEAGTGISKPRVGP---GA
Mflv_1582|M.gilvum_PYR-GCK ------REAEPELPADNNVGPEPRTVGSVDH-------------------
MUL_0464|M.ulcerans_Agy99 ------RNAEPALPADNDVGSDPTTLPSVNG-------------------
TH_4550|M.thermoresistible__bu -----------GVAAWMDRHR-----------------------------
MLBr_00175|M.leprae_Br4923 -----GQTLPVGTAEKAVIRGELFMSQRTAS-------------------
Mb1056c|M.bovis_AF2122/97 HIASWLAALVVPSVICAITVAWLDRFMGIGGESALFFIGVLIVALLGGVA
Rv1028c|M.tuberculosis_H37Rv HIASWLAALVVPSVICAITVAWLDRFMGIGGESALFFIGVLIVALLGGVA
MAV_1170|M.avium_104 RVASWLAALIVPSVICAVTVTWLDPYLDTGGESALFFVGVLLVGLLGGIA
MMAR_0634|M.marinum_M HLVSWLAAVVVPSLICALTVAWLDRFLAVGGESALFVIGVLVVALLGGVA
Mvan_4762|M.vanbaalenii_PYR-1 HAVSWLAALAVPGAICAATVLLLDRFLGIGGESAMFFIGVLVVALLGGVA
MAB_3251c|M.abscessus_ATCC_199 LIINWLAAILVP-PATALFIHFFDTAFGVGSKSALFLIAVLGVSLLGGVS
MSMEG_5372|M.smegmatis_MC2_155 SVTGWLAAVALPPAICALLLAVPP--LGVGTQTALFVAGVLMIALLGGIA
Mflv_1582|M.gilvum_PYR-GCK --------------------------------SDVQWRAMTVRGLRGELT
MUL_0464|M.ulcerans_Agy99 --------------------------------SNIEWRAVSVHGPQGGLT
TH_4550|M.thermoresistible__bu --------------------------------AELQEAATNSLLLYG---
MLBr_00175|M.leprae_Br4923 ---------------------------------DQRILAIHLPNDSSLLI
. .
Mb1056c|M.bovis_AF2122/97 PAALSALLSGMLLNYFLTEPRYTWTIAEPDAAVTEFVLLAMAVAVAVLVD
Rv1028c|M.tuberculosis_H37Rv PAALSALLSGMLLNYFLTEPRYTWTIAEPDAAVTEFVLLAMAVAVAVLVD
MAV_1170|M.avium_104 PAALSAVLSGLLLNYYLIAPRHSFTIAEPNSAITELVLLLIAVAVAVLVD
MMAR_0634|M.marinum_M PAALSAVLSGLLLNYFLIEPRYTFTIADPDNAVTTLVLLVVAVAVAALVD
Mvan_4762|M.vanbaalenii_PYR-1 PAALSAVLSGVLLNFFLVEPRHTFTISEPDSAITIVVLLVVAVAVAALVD
MAB_3251c|M.abscessus_ATCC_199 TALVSAVISGLLLNFLFVAPRYSFTIGETDNALTILMMMVTAVAVAALVD
MSMEG_5372|M.smegmatis_MC2_155 RAALSAVLSGVLITYFLIEPRNSFAVAGADSALTTGVLLGLAIAVAGLVD
Mflv_1582|M.gilvum_PYR-GCK TVAID--------------------LSDVKSTMRSLVYTQVGIGAAVLLV
MUL_0464|M.ulcerans_Agy99 TVAID--------------------LSDVQHTVRSLVWLQIGIGAGVLVV
TH_4550|M.thermoresistible__bu --------------------------AVAMAAVTALAAVVAWLVAGRVLS
MLBr_00175|M.leprae_Br4923 SKSLR----------------------PTEAVMTKLRWVLLIVGSLGVAV
.: : :
Mb1056c|M.bovis_AF2122/97 GAASRTREARRASQEAELLALFAGSVLRGADLATLLQRVRETYSQRAVTM
Rv1028c|M.tuberculosis_H37Rv GAASRTREARRASQEAELLALFAGSVLRGADLATLLQRVRETYSQRAVTM
MAV_1170|M.avium_104 FAAKRTREARRASQEAELLTLFAGSVLRGADLETLLERVRETYAQRSVSM
MMAR_0634|M.marinum_M NAAKRSREAGRASREAELLALFAGSVLRGADLEALLEKVRETYSQRAVSI
Mvan_4762|M.vanbaalenii_PYR-1 GAANRTRESRRAAREAELLALFAGAVLRGADLNTLLERVREAYSQQSVTL
MAB_3251c|M.abscessus_ATCC_199 AAATRARQARRASREAELLALFAGGVLVNSDLSALLERVRTTYNQTAVSL
MSMEG_5372|M.smegmatis_MC2_155 QTARHSRAARRASQNAELLALFADGVLRDADPGALLERVRETYAQRSVSL
Mflv_1582|M.gilvum_PYR-GCK LGIAGYAVVHRSLRPLSEVEQTAAAIAAGQLDR-----------------
MUL_0464|M.ulcerans_Agy99 VGLAGFAVVQRSLRPLSEVEQTAAAIASGQLDR-----------------
TH_4550|M.thermoresistible__bu PLHRVTATARRISRAPALSSGLR---------------------------
MLBr_00175|M.leprae_Br4923 AAVAGGMVTRAGLRPVGRLTEAAERVARTDDLR-----------------
:
Mb1056c|M.bovis_AF2122/97 LR----VRQGASTGETVACVGTNPCRDVDSADTAIEVG----DDEFWMLM
Rv1028c|M.tuberculosis_H37Rv LR----VRQGASTGETVACVGTNPCRDVDSADTAIEVG----DDEFWMLM
MAV_1170|M.avium_104 LRESEDARAGGTKTQVVACVGRDPCVSVDAADTAIEVGGPD-SSEFQMLL
MMAR_0634|M.marinum_M LR----IEAGTSQGAIVSCVGEDPCVDVDTADTAIDVG----DDEFWMLM
Mvan_4762|M.vanbaalenii_PYR-1 VR------GEAHGGGVVGCAGSEPCVTVETADTAIEVGSKDDPEEFWLLL
MAB_3251c|M.abscessus_ATCC_199 LC---------AEGPAVASVGEDPPTRESEADSVFRVD----DGAYALAL
MSMEG_5372|M.smegmatis_MC2_155 LR--------GRTGEVLAHAGANPCTDIDEADTTIEIG----DDEYWLLL
Mflv_1582|M.gilvum_PYR-GCK --------------------------RVPERDPRTEVG------------
MUL_0464|M.ulcerans_Agy99 --------------------------RVPERDPRTEVG------------
TH_4550|M.thermoresistible__bu -------------------------ERIQLAGPADEVK------------
MLBr_00175|M.leprae_Br4923 --------------------------PIPVFGSDELAR------------
..
Mb1056c|M.bovis_AF2122/97 AGRKLAARDRRVLTAVATQAAGLVKQRELAEEAGQAEAIARADELRRSLL
Rv1028c|M.tuberculosis_H37Rv AGRKLAARDRRVLTAVATQAAGLVKQRELAEEAGQAEAIARADELRRSLL
MAV_1170|M.avium_104 AGRKLSARDRRVLSAVARQAAGLIRQRELAEEASRTEAIVRADELRRSLL
MMAR_0634|M.marinum_M AGRKLLARDRRVLTAVAKQAAGLIKQRELADEAGKAQAIEQADQLRRALL
Mvan_4762|M.vanbaalenii_PYR-1 AGRRLDARDRRVLGAVANQAAGLARQRELAEEAGRAEAIARADELRRSLL
MAB_3251c|M.abscessus_ATCC_199 NGPPVPSSDARVLQVVAGTAVGLVRSARLAEEASQASALAEADRLRRALL
MSMEG_5372|M.smegmatis_MC2_155 AGPDLTSHDRRVLNAVAEQAVSLVKKRRQADEAIKFD--TEAEKLRSSIQ
Mflv_1582|M.gilvum_PYR-GCK -----------RLSLALNGMLAQIQHAMALSESSAEKARSSEDRMRR-FI
MUL_0464|M.ulcerans_Agy99 -----------QLSLAMNGMLSQIQVALAASEDSAEKARSSEERMRR-FI
TH_4550|M.thermoresistible__bu -----------DLADTFDQMLCRLDRAFAG---------------QRRFV
MLBr_00175|M.leprae_Br4923 ------------LTEAFNLMLRALAE---------------SRERQARLV
* . : :
Mb1056c|M.bovis_AF2122/97 SAVSHDLRTPLAAAKV----AVSSLRTEDVAFSPEDTAELLATIEESIDQ
Rv1028c|M.tuberculosis_H37Rv SAVSHDLRTPLAAAKV----AVSSLRTEDVAFSPEDTAELLATIEESIDQ
MAV_1170|M.avium_104 SAVSHDLRTPLAAAKV----AVSSLRAEDVAFSPTDTAELLATIEESIDQ
MMAR_0634|M.marinum_M SAVSHDLRTPLAAAKA----AVSSLRSDDVDFSADDMGELLATIEESVDQ
Mvan_4762|M.vanbaalenii_PYR-1 SAVSHDLRTPLAAAKA----AVSSLRSEDVGFSPEDTAELLATVEESIDQ
MAB_3251c|M.abscessus_ATCC_199 SAVSHDLRTPLAAVKA----AVSSLRSPDIEFSPEDTAELLATVEESADQ
MSMEG_5372|M.smegmatis_MC2_155 SAITHNLRTPLVTAKA----AIAGAAHDNP--PPDDTVELLAAAEKSVDE
Mflv_1582|M.gilvum_PYR-GCK TDASHELRTPLTTIRG----FAELYR----QGAARDVEMLMGRIKSESRR
MUL_0464|M.ulcerans_Agy99 TDASHELRTPLTTIRG----FAELYR----QGAARDVAMLLSRIESEASR
TH_4550|M.thermoresistible__bu GDASHELRTPVAVSRA----MIELAMRR--NPGSPELIRLGTDLLEVNER
MLBr_00175|M.leprae_Br4923 TDAGHELRTPLTSLRTNVELLIASMAPEAPRLPDQEMADLRADVLAQIEE
*:****:. : : * .
Mb1056c|M.bovis_AF2122/97 LTALVANLLDSSRLAAG--VIRPQLRRAYLEEAVQRALVSIGKGATGFYR
Rv1028c|M.tuberculosis_H37Rv LTALVANLLDSSRLAAG--VIRPQLRRAYLEEAVQRALVSIGKGATGFYR
MAV_1170|M.avium_104 LTALVGNLLDSSRLAAG--AIHPDLRRVYLEEAVQRALVSIGKGATGFFR
MMAR_0634|M.marinum_M LTALVGNLLDSSRLAAG--VVRPQLRRVYLEETVQRALLGISRGATGYGR
Mvan_4762|M.vanbaalenii_PYR-1 LSGLVGNLLDSSRLAAG--VVRPELQPVYLEEAVPRALLGISRGSTGL-R
MAB_3251c|M.abscessus_ATCC_199 LTALVGNLLDSSRLAAG--VVKPRAVPVYVDEIAQRALLGATE-------
MSMEG_5372|M.smegmatis_MC2_155 LSVLVVNLLDSSCLATG--AIRPELRPVDLRDAVEHVLRDIGP-------
Mflv_1582|M.gilvum_PYR-GCK MGLLVEDLLLLARLDAQRPLEHRRVDLLALASDTVHDAQSIAPK-----R
MUL_0464|M.ulcerans_Agy99 MGLLVDDLLTLARLDVQRPLERNRVDLLVLAADAVHDARAIDRK-----R
TH_4550|M.thermoresistible__bu LERLITGLLALTNAENG-VIDAHTVDLADVAGHAAAQLAGTAR-------
MLBr_00175|M.leprae_Br4923 LSTLVGDLVDLTRDDAG----QVVHEPIDMSEVLYRSLERVRRR------
: *: .*: : :
Mb1056c|M.bovis_AF2122/97 SGIDRVKVDVGDAVAMADAGLLERVLANLIDNALRYAP--------DCVV
Rv1028c|M.tuberculosis_H37Rv SGIDRVKVDVGDAVAMADAGLLERVLANLIDNALRYAP--------DCVV
MAV_1170|M.avium_104 SAIDRVKVDVGDAMVMADAGLLERVLANLIDNALRYAP--------NCVV
MMAR_0634|M.marinum_M SGLDRVKVEVGGAVAIADAGLLERVLANLIDNGLRYAP--------DSPV
Mvan_4762|M.vanbaalenii_PYR-1 AGLDRVKVEVGDTVVMADSGLLERVLANVIDNALRYAP--------DGPV
MAB_3251c|M.abscessus_ATCC_199 NDRKRVHLDLGGAVVRADPGLLERVLANLVDNALRYS---------QGEV
MSMEG_5372|M.smegmatis_MC2_155 -DARRVHVDVDGTPVLADGELLGRVLGNLLTNSLRYGDPDGDSAGDSGVV
Mflv_1582|M.gilvum_PYR-GCK RIRMEVFDGPGTPEVLGDEARLRQVLSNLVANALQHTP-------ESAGV
MUL_0464|M.ulcerans_Agy99 AITVEVLEGPGTPEVLGDEPRLRQVLSNLVGNALQHTP-------DSADV
TH_4550|M.thermoresistible__bu ARSVEVDTTLSEAVTRGDATLLERLAHNLIENAVKYSG------DDSPRV
MLBr_00175|M.leprae_Br4923 RNDIHFDVQAIGWQIYGDAAGLSRAVLNLMDNAAKWSP-------SGGRV
.. .* * : *:: *. : *
Mb1056c|M.bovis_AF2122/97 RVNAGRVRER-VLINVIDEGPGVPRGTEEQLFAPFQRP--GDHDNTTGVG
Rv1028c|M.tuberculosis_H37Rv RVNAGRVRER-VLINVIDEGPGVPRGTEEQLFAPFQRP--GDHDNTTGVG
MAV_1170|M.avium_104 RVNAGQVGDR-VLINVIDEGPGIPHGAEEQIFEAFQRL--GDHDNTTGVG
MMAR_0634|M.marinum_M RVYAGRVGDR-VLINVADEGPGIPRGAEEQMFAPFQRL--GDRDNRIGVG
Mvan_4762|M.vanbaalenii_PYR-1 RVTAGRVADR-VLIAVADEGPGVARGAETELFAPFQRL--GDQDTSSGVG
MAB_3251c|M.abscessus_ATCC_199 RVSHEEVDDR-TLVIVADHGKGLEASKRGAAFDAFQRL--GDRDNTVGVG
MSMEG_5372|M.smegmatis_MC2_155 RVTAGQVDDR-VLIAVVDSGPGIPRGSEHEAFAPFQRL--GRDDANIGVG
Mflv_1582|M.gilvum_PYR-GCK TVRVGTADDT-AIVEVCDEGPGMTGEDAQRVFERFYRADSSRARASGGTG
MUL_0464|M.ulcerans_Agy99 TVRVGTAGEN-AVLEVADKGPGMPAEDAARVFERFYRTDSSRARASGGTG
TH_4550|M.thermoresistible__bu VVTTGSLSDSQVFLRVSNNGEPIRDEDLPTLFEPFRRL--TRDTRASGAG
MLBr_00175|M.leprae_Br4923 VVTMRQFDPSHVELVVSDYGPGIPPQERRLVFERFYRS--TTARSLPGSG
* . : * : * : * * * * *
Mb1056c|M.bovis_AF2122/97 LGMSVARGFVEAMGGTISATDTPG----GGLTVVIDLAAPEDRP------
Rv1028c|M.tuberculosis_H37Rv LGMSVARGFVEAMGGTISATDTPG----GGLTVVIDLAAPEDRP------
MAV_1170|M.avium_104 LGMSVARGFVEAMGGTITATDTPG----GGLTVMVDMAAPQSEGAA----
MMAR_0634|M.marinum_M LGLSVAKGFVEAMGGTISATDTPG----GGLTVVVDLAAA----------
Mvan_4762|M.vanbaalenii_PYR-1 LGLSVARGFVEAMGGTISATDTPG----GGMTVEIDLAAPR---------
MAB_3251c|M.abscessus_ATCC_199 LGLSVVKGFVEAMEGTVNATDTAG----GGLTMIVDLPSAGSAPTGAIR-
MSMEG_5372|M.smegmatis_MC2_155 LGLPVASGLVEAMGGKISMTETPG----GGLTVEIDLPAARRSE------
Mflv_1582|M.gilvum_PYR-GCK LGLSIVDSLVYAHGGRVSVTTAPG----CGCRFTVRLPRVTDERLREEQA
MUL_0464|M.ulcerans_Agy99 LGLSIVHSLVKAHGGDVTLTTAPG----EGCCFRVTLPRVS---------
TH_4550|M.thermoresistible__bu LGLSIAAAIVQAHQGTIEATARPD----GGLTVEVVLPAPAAARP-----
MLBr_00175|M.leprae_Br4923 LGLAIVKQVVINHGGLLRVEDTAPGVQPPGTSIYVLLPGRPMPVSAYSTL
**:.:. .* * : . * . : :.
Mb1056c|M.bovis_AF2122/97 --------------------------------------------
Rv1028c|M.tuberculosis_H37Rv --------------------------------------------
MAV_1170|M.avium_104 --------------------------------------------
MMAR_0634|M.marinum_M --------------------------------------------
Mvan_4762|M.vanbaalenii_PYR-1 --------------------------------------------
MAB_3251c|M.abscessus_ATCC_199 --------------------------------------------
MSMEG_5372|M.smegmatis_MC2_155 --------------------------------------------
Mflv_1582|M.gilvum_PYR-GCK TDERLREEQMPAPEHAGEESRGEQTDVPVSATAPTPP-------
MUL_0464|M.ulcerans_Agy99 -------------------------EAAVELTEPVS--------
TH_4550|M.thermoresistible__bu --------------------------------------------
MLBr_00175|M.leprae_Br4923 ADQDMGEANFQDKIGPAVQVSGKSANFRDSAHVISVDYQSARAR