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AMTLIALEEHLIPADLVDQLWPLPSDPRGILPKLTAVGEQRLRVMDDAGIDLQVLSVTAPGTQQVDPEYA GDLSRTLNDRCAEIVAAHPDRFNALASLPTQIPTAAVVEAKRAITELGMCGVVINGHTQGTFLDAPEFDE LLSAIEELGVPVYLHPTYPPAQVAEVYFGGLTPEIGSALATAAWGWHAETGLHVLRLAASGVFDRHPALQ FVVGHMGENLPFSLMRADAVLSGYNPGGPSVAETVRAHVHITISGYTTAPPLLCALQVFGADRIMFAADY PYGDAVTHAEFLAQAPISPADREKIAHVNARQLFRL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5364 | - | - | 100% (317) | amidohydrolase 2 |
| M. smegmatis MC2 155 | MSMEG_4063 | - | 2e-51 | 38.79% (281) | amidohydrolase family protein |
| M. smegmatis MC2 155 | MSMEG_6813 | - | 9e-25 | 25.89% (309) | amidohydrolase 2 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. gilvum PYR-GCK | Mflv_0351 | - | 4e-06 | 24.68% (158) | amidohydrolase 2 |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0299 | - | 7e-27 | 29.39% (279) | putative amidohydrolase (aminocarboxymuconate-semialdehyde |
| M. marinum M | MMAR_1500 | - | 4e-19 | 26.64% (304) | hypothetical protein MMAR_1500 |
| M. avium 104 | MAV_0481 | - | 1e-48 | 40.89% (291) | amidohydrolase family protein |
| M. thermoresistible (build 8) | TH_2827 | - | 3e-08 | 25.63% (277) | PUTATIVE amidohydrolase 2 |
| M. ulcerans Agy99 | MUL_2437 | - | 2e-19 | 26.56% (305) | hypothetical protein MUL_2437 |
| M. vanbaalenii PYR-1 | Mvan_0901 | - | 1e-08 | 24.10% (332) | amidohydrolase 2 |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_5364|M.smegmatis_MC2_155 --------------------------------------------------
MAV_0481|M.avium_104 --------------------------------------------------
MMAR_1500|M.marinum_M --------------------------------------------------
MUL_2437|M.ulcerans_Agy99 MGTRLEPHRGRRIHLGADDLPGNQHLGPYSRGTAHHRQVGPVQDGGAFVA
Mflv_0351|M.gilvum_PYR-GCK ---------MPEPAPQFRDAPIFDADQHMYETPDALTKFLPDRYTRAVQY
TH_2827|M.thermoresistible__bu ---------VTAPA-----LEIWDADNHLYEPTDAYTRHLPKQYRGAIQW
MAB_0299|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_0901|M.vanbaalenii_PYR-1 ---------------MGSSTLIIDTDTHITEPPDLWTSRMSKSRWGNLIP
MSMEG_5364|M.smegmatis_MC2_155 ---------------MAMTLIALEEHLIPADLVDQLWPLP----------
MAV_0481|M.avium_104 -----------------MRIITVEEHFQHPEVSARVAELTGPAVEGLAEF
MMAR_1500|M.marinum_M -----------------MWRIDTHHHMIPPDYRRALRNAG--------VD
MUL_2437|M.ulcerans_Agy99 AARGQRGAALRPGKEFAIWRIDTHHHMIPPDYRRALRNAG--------VD
Mflv_0351|M.gilvum_PYR-GCK GQFGRHTRIVINNRVSDFIPNPTFERVAAPGAHEKFFAGENTEGLTLREM
TH_2827|M.thermoresistible__bu IQVDGLTKLMIKGRLTDTIPNPTYEVVASPGAWADYFRGINPEGKSLREL
MAB_0299|M.abscessus_ATCC_1997 ---------------MTSVRIDIHAHLWSDEYLSLLDGYGRP------AT
Mvan_0901|M.vanbaalenii_PYR-1 EVKWVEEKQGEYWCMDGQPVFTVGTCIMVPGEDGKPVRSPR------FPD
.
MSMEG_5364|M.smegmatis_MC2_155 SDPRGILPKLTA-VGEQRLRVMDDAGIDLQVLSVTAP-------GTQQV-
MAV_0481|M.avium_104 GNAFSLDPDSTARLGGNRLAHMDQVGIDVQVVSHGNG-------SPGTL-
MMAR_1500|M.marinum_M GAGGRALPDWSP---AGSLQAMAELTVGAAILSVSAP-------ATAFLP
MUL_2437|M.ulcerans_Agy99 GAGGRALPDWSP---AGSLQAMAELTVGAAILSVSAP-------ATAFLP
Mflv_0351|M.gilvum_PYR-GCK QGPAIEAPAATR-NPADRVAELDRQGVREALNYPTLASL----IEHATAD
TH_2827|M.thermoresistible__bu ANP-IRCPEEFR-HAEQRLRLLDAQGIQACVMFPTTGGM----LEERMLD
MAB_0299|M.abscessus_ATCC_1997 DVHRGLGAGATRDDLDGRFELMDEAGVDLQILTATPA--------SPHFE
Mvan_0901|M.vanbaalenii_PYR-1 YADRFSSMHPSAYDAKARLEVMDAYGIQAAAIFPNLGFVGPNIFAAAGPD
. : :
MSMEG_5364|M.smegmatis_MC2_155 DPEYAGDLSRTLNDRCAEIVAAHPD-RFNALASLPTQIPTAAVVEAKRAI
MAV_0481|M.avium_104 QHPEAVELCRRVNNDLAAQIAENPD-RFRGFATLPLYDPAAAAEELRRCV
MMAR_1500|M.marinum_M QASDAAALARDINDYAADIVAGRPT-QFGFFATVPMPHLDQSVAETVRAL
MUL_2437|M.ulcerans_Agy99 QASDAAALARDINDYAADVVAGRPA-QFGFFATVPMPHLDQSVAETVRAL
Mflv_0351|M.gilvum_PYR-GCK DPELTLAVIHALNQWMAEHWTFDYQGRVFSTPIINLSEVDGAQRELEYIL
TH_2827|M.thermoresistible__bu DIELTHAVVHAYNEWLLEEWTFDYAGRIFATPVITLPDVDKAVAELNWCV
MAB_0299|M.abscessus_ATCC_1997 DQAAAVASARFINDEYAKLSSEYPG-RFGALASLPLPHVPAALEELARAI
Mvan_0901|M.vanbaalenii_PYR-1 ALEFQTAALQAYNDFLLDWSSIAPD-RLLSLALIPYWDVDAAVAEIERCA
: *: : :. . : : *
MSMEG_5364|M.smegmatis_MC2_155 TELGMCGVVINGHTQGT-----FLDAPEFDELLSAIEELGVPVYLHPTYP
MAV_0481|M.avium_104 GDLGFVGALIAGSYDGL-----FLDDERFDPILTAAEAVDFPIYVHPGLP
MMAR_1500|M.marinum_M DDLKADGVVLLANHAGV-----YLGEDGQDDLFTALNSRAAVVFVHPAEL
MUL_2437|M.ulcerans_Agy99 DDLKADGVVLLANHAGV-----YLGEDGQDDLFTALNSRAAVVFVHPAEL
Mflv_0351|M.gilvum_PYR-GCK TQGARVALIKPGPVNGLRGWR-SPALPEFDPFWRDVESAGLPIVLHASYP
TH_2827|M.thermoresistible__bu ENGARAVLVNPRPVATITGHTTSMGQPYFDPFWHRVEQLGIPVLMHACDS
MAB_0299|M.abscessus_ATCC_1997 DELGMYGASITTSVLGR-----SIADPIFDPLYAELNRRRAVLFVHPAGC
Mvan_0901|M.vanbaalenii_PYR-1 AAGHKGLVSTGKPHEHG---YKLLADRYWDPMWAAAQDANLSISFHVGGG
* : : : .*
MSMEG_5364|M.smegmatis_MC2_155 PAQVAEVYFGG-LTPEIGSALATAAWGWHAET-----GLHVLRLAASGVF
MAV_0481|M.avium_104 EAPVSQRYYAGSWPASVHMMFSGPAFGWHAEA-----GIHIVRLILSGAL
MMAR_1500|M.marinum_M PGPAVPG-------------VAPWAGDFLLDT-----TRAAHLLVRNGIR
MUL_2437|M.ulcerans_Agy99 PGPAVPG-------------VAPWAGDFLLDT-----TRAAHLLVRNGIR
Mflv_0351|M.gilvum_PYR-GCK PLDDYVGKWEP---PYTQNFMTQSAFRWMVLG-HREIADMITALICHGTL
TH_2827|M.thermoresistible__bu GYDRYSRDWEGKGGEYTP--FKPDAFRTIVYEDARSILDTCAALVAHGVF
MAB_0299|M.abscessus_ATCC_1997 GAESSLITDHS----------LTWSIGAPIED-----TVAIMHLIVAGVP
Mvan_0901|M.vanbaalenii_PYR-1 NLSRHLNDERT-SVEGWRATLARLTTSFFLES-----GITLADLLMSGVL
: * *
MSMEG_5364|M.smegmatis_MC2_155 DRHPALQFVVGHMG-ENLPFSLMRADAVLSGYN--------PGGP-SVAE
MAV_0481|M.avium_104 DRHPTLKLLSGHWG-ELAAFYLERLDETLGLLP--------TGLERAPSD
MMAR_1500|M.marinum_M QRYPDIKFVLSHAG-GFVPYASHRLALAITADT--------GRSPADVLE
MUL_2437|M.ulcerans_Agy99 QRYPDINFVLSHAG-GFVPYASHRLALVITADT--------GRSPADVLE
Mflv_0351|M.gilvum_PYR-GCK TRFPKLRIASVENGSSWIFPLFNDFEELAKKMP--------QNFGEHPLD
TH_2827|M.thermoresistible__bu TRHPGVRVGVVENGGAWVPRLIDLFERVYKKMP--------NEFGAHPVE
MAB_0299|M.abscessus_ATCC_1997 SRYPDMKIVTCHLG-GALPMVLERAHRQVTEWE--------ATQCPEAPR
Mvan_0901|M.vanbaalenii_PYR-1 ARYPKLRFVSVESAVGWIPFLLESLDFHYKKYEPWLERPEFAGNDMLPSD
*.* :.. . .
MSMEG_5364|M.smegmatis_MC2_155 TVRAHVHITISGYTTAPPLLCALQVFGADRIMFAADYPYGDAVT-----H
MAV_0481|M.avium_104 YYRQQVWITPSGMYNQNQLNFMTAELGAQRIIYSEDFPYVVRDN-----V
MMAR_1500|M.marinum_M EFSS-FYFDTALSSSAAALPTLIAFAKPGHITFGSDWPFAPTAAGK-LFA
MUL_2437|M.ulcerans_Agy99 EFSS-FYFDTALSSSAAALPTLIAFAKPGHITFGSDWPFAPTAAGK-LFA
Mflv_0351|M.gilvum_PYR-GCK VFRRNIWVSP---FWEGCVSDVVTTVGWDKVMFGSDYPHPEGLPEP---K
TH_2827|M.thermoresistible__bu QFREHVWVNP---FHEEDLSGLIDLIGADRVLFGSDFPHPEGLAEP---A
MAB_0299|M.abscessus_ATCC_1997 DAARRLWYDTVGHDHTPALRAAVASLGVDRLIFGSDFPYQAGPR---YVS
Mvan_0901|M.vanbaalenii_PYR-1 YFHRQVYANY---WYEDLQPWHVAAIGEDNLMFETDYPHQTCLDKEEIQH
. .: : *:*.
MSMEG_5364|M.smegmatis_MC2_155 AEFLAQAPISPADREKIAHVNARQLFRL----------------------
MAV_0481|M.avium_104 STFLEQAGLSEADTHAIAHTNAEALLRI----------------------
MMAR_1500|M.marinum_M AGLETYPALDAAARGAIDRGSALSLFPRFGVAAPPPQPSAAQRIRHTLSR
MUL_2437|M.ulcerans_Agy99 AGLETYPALDAAARGAIDRGSALSLFPRFGVAAPPPQPSAAQRIRHTLSR
Mflv_0351|M.gilvum_PYR-GCK GFWKYAEGMDVRRTYDFMGDNARRFMGLPIANPDPEAARPPALSTA----
TH_2827|M.thermoresistible__bu KLTPEIAELPEPTIEAVMGGNLR---ELLTAVPHGR--------------
MAB_0299|M.abscessus_ATCC_1997 SATYIEEGLSAEDASAILDHNGAELLGLTGV-------------------
Mvan_0901|M.vanbaalenii_PYR-1 SINEGLSGVSETTKEKILWRNAASLFNMDIAKLEKLT-------------
: . .
MSMEG_5364|M.smegmatis_MC2_155 --------------
MAV_0481|M.avium_104 --------------
MMAR_1500|M.marinum_M TAMRGVARLMNSGG
MUL_2437|M.ulcerans_Agy99 TAMRGVARLMNSGG
Mflv_0351|M.gilvum_PYR-GCK --------------
TH_2827|M.thermoresistible__bu --------------
MAB_0299|M.abscessus_ATCC_1997 --------------
Mvan_0901|M.vanbaalenii_PYR-1 --------------