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DDSYEALLQHFMPDRDSSERLGGRRLTHMDRVGIDVQVVSHGANNPGSLNHHEATELCRTANDALAQDIS EHPTRFRGFATIPLHDPHAAADEMRRCVNELGFVGTLVMGTCAGTFLDDDRYEPVLSAAEEVDRPIYLHP GLPPASVSNAYYAGNWPGAVQWVFAGPGFGWHAEAGIHTIRMILSGALDRHPNLKMLSGHWGEFVAGWLD RLDEVFAWCHHLDRPISQYYRDHVWITPSGMFNQNRLKFILAELGHERIIYSEDYPYVESESVSEFLESA ELSEDQRASIAHRNAQNLLHI*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4063 | - | - | 100% (302) | amidohydrolase family protein |
| M. smegmatis MC2 155 | MSMEG_5364 | - | 2e-51 | 38.79% (281) | amidohydrolase 2 |
| M. smegmatis MC2 155 | MSMEG_6813 | - | 2e-17 | 23.96% (288) | amidohydrolase 2 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3540c | - | 4e-08 | 26.67% (240) | hypothetical protein Mb3540c |
| M. gilvum PYR-GCK | Mflv_0351 | - | 1e-06 | 25.56% (270) | amidohydrolase 2 |
| M. tuberculosis H37Rv | Rv3510c | - | 4e-08 | 26.67% (240) | hypothetical protein Rv3510c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0299 | - | 1e-19 | 24.84% (314) | putative amidohydrolase (aminocarboxymuconate-semialdehyde |
| M. marinum M | MMAR_1500 | - | 2e-09 | 27.27% (154) | hypothetical protein MMAR_1500 |
| M. avium 104 | MAV_0481 | - | 1e-108 | 63.70% (292) | amidohydrolase family protein |
| M. thermoresistible (build 8) | TH_4037 | - | 5e-07 | 24.58% (240) | PUTATIVE amidohydrolase 2 |
| M. ulcerans Agy99 | MUL_2437 | - | 2e-08 | 25.97% (154) | hypothetical protein MUL_2437 |
| M. vanbaalenii PYR-1 | Mvan_0901 | - | 1e-08 | 23.30% (309) | amidohydrolase 2 |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_4063|M.smegmatis_MC2_155 --------------------------------------------------
MAV_0481|M.avium_104 --------------------------------------------------
Mb3540c|M.bovis_AF2122/97 --------------------------------------------------
Rv3510c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_0351|M.gilvum_PYR-GCK MPEPAPQFRDAPIFDADQHMYETPDALTKFLPDRYTR-AVQYGQFGRHTR
TH_4037|M.thermoresistible__bu ---VIMTELDYRAIDVDNHYYEPLDAFTRYLPKEFTRRGVQMLTDGKRTF
MMAR_1500|M.marinum_M --------------------------------------------------
MUL_2437|M.ulcerans_Agy99 -MGTRLEPHRGRRIHLGADDLPGNQHLGPYSRGTAHHRQVGPVQDGGAFV
MAB_0299|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_0901|M.vanbaalenii_PYR-1 ------MGSSTLIIDTDTHITEPPDLWTSRMSK------SRWGNLIPEVK
MSMEG_4063|M.smegmatis_MC2_155 -----------------------------MDDSYEALLQH---FMPDRDS
MAV_0481|M.avium_104 -MRIITVEEHFQHPEVS------ARVAELTGPAVEGLAEFGNAFSLDPDS
Mb3540c|M.bovis_AF2122/97 ----MTIDVWMQHPTQR----------FLHGDMFASLRRWTGGSIPETDI
Rv3510c|M.tuberculosis_H37Rv ----MTIDVWMQHPTQR----------FLHGDMFASLRRWTGGSIPETDI
Mflv_0351|M.gilvum_PYR-GCK IVINNRVSDFIPNPTFERVAAPGAHEKFFAGENTEGLTLR-EMQGPAIEA
TH_4037|M.thermoresistible__bu ALMGEKVNHFIPNPTFDPIIEPGCLDLLFRGEIPEGVDPGSLMKVDRLAN
MMAR_1500|M.marinum_M ------------------MWRIDTHHHMIPPDYRRALRNAGVDGAGGRAL
MUL_2437|M.ulcerans_Agy99 AAARGQRGAALRPGKEFAIWRIDTHHHMIPPDYRRALRNAGVDGAGGRAL
MAB_0299|M.abscessus_ATCC_1997 ----------MTSVRIDIHAHLWSDEYLSLLDGYGRPATDVHRGLGAGAT
Mvan_0901|M.vanbaalenii_PYR-1 WVEEKQGEYWCMDGQPVFTVGTCIMVPGEDGKPVRSPRFPDYADRFSSMH
MSMEG_4063|M.smegmatis_MC2_155 SERLGGR--RLTHMDRVGIDVQVVSHGANNPGS----LNHHEATELCRTA
MAV_0481|M.avium_104 TARLGGN--RLAHMDQVGIDVQVVSHGNGSPGT----LQHPEAVELCRRV
Mb3540c|M.bovis_AF2122/97 PIEAT-----VSSMDAGGVTLGLLSAWRGPNGQ----DLISNDAVAEWVR
Rv3510c|M.tuberculosis_H37Rv PIEAT-----VSSMDAGGVTLGLLSAWRGPNGQ----DLISNDAVAEWVR
Mflv_0351|M.gilvum_PYR-GCK PAATRNPADRVAELDRQGVREALNYPTLASLIE----HATADDPELTLAV
TH_4037|M.thermoresistible__bu HPEYQNRDERVKILDKQNLETVFMLPTFACGVE----EGLKHDIEATMVS
MMAR_1500|M.marinum_M PDWSPAG--SLQAMAELTVGAAILSVSAPATAF----LPQASDAAALARD
MUL_2437|M.ulcerans_Agy99 PDWSPAG--SLQAMAELTVGAAILSVSAPATAF----LPQASDAAALARD
MAB_0299|M.abscessus_ATCC_1997 RDDLDGR---FELMDEAGVDLQILTATPASPHF----EDQAAAVASARFI
Mvan_0901|M.vanbaalenii_PYR-1 PSAYDAK-ARLEVMDAYGIQAAAIFPNLGFVGPNIFAAAGPDALEFQTAA
. : :
MSMEG_4063|M.smegmatis_MC2_155 NDALAQDISEH------PTRFRGFATIPLHDPHAAADEMRRCVNELGFVG
MAV_0481|M.avium_104 NNDLAAQIAEN------PDRFRGFATLPLYDPAAAAEELRRCVGDLGFVG
Mb3540c|M.bovis_AF2122/97 LYPN---------------RFAGLAAVDLDRPMAAVRELRRRVGEGFVGL
Rv3510c|M.tuberculosis_H37Rv LYPN---------------RFAGLAAVDLDRPMAAVRELRRRVGEGFVGL
Mflv_0351|M.gilvum_PYR-GCK IHALNQWMAEHWTFDY-QGRVFSTPIINLSEVDGAQRELEYILTQGARVA
TH_4037|M.thermoresistible__bu LHAFNLWLDEDWGFDRPDGRILSAPMISLADPEKAVEEVEFVLNRGARIV
MMAR_1500|M.marinum_M INDYAADIVAG-----RPTQFGFFATVPMPHLDQSVAETVRALDDLKADG
MUL_2437|M.ulcerans_Agy99 INDYAADVVAG-----RPAQFGFFATVPMPHLDQSVAETVRALDDLKADG
MAB_0299|M.abscessus_ATCC_1997 NDEYAKLSSEY------PGRFGALASLPLPHVPAALEELARAIDELGMYG
Mvan_0901|M.vanbaalenii_PYR-1 LQAYNDFLLDWSS--IAPDRLLSLALIPYWDVDAAVAEIERCAAAGHKGL
:. . : : *
MSMEG_4063|M.smegmatis_MC2_155 TLVMGTCAG----TFLDDDRYEPVLSAAEEVDRPIYLHPGLPPASVSNAY
MAV_0481|M.avium_104 ALIAGSYDG----LFLDDERFDPILTAAEAVDFPIYVHPGLPEAPVSQRY
Mb3540c|M.bovis_AF2122/97 RVVPWLWG-----APPTDRRYYPLFAECVQSAVPFCTQVGHTG-------
Rv3510c|M.tuberculosis_H37Rv RVVPWLWG-----APPTDRRYYPLFAECVQSAVPFCTQVGHTG-------
Mflv_0351|M.gilvum_PYR-GCK LIKPGPVNGLRGWRSPALPEFDPFWRDVESAGLPIVLHASYPPLDDYVGK
TH_4037|M.thermoresistible__bu CVRPAPVPGVVKPRSLGDPVHDPVWARLAEAGVPVIFHLSDSGYLAISAL
MMAR_1500|M.marinum_M VVLLANHAG----VYLGEDGQDDLFTALNSRAAVVFVHPAELPGPAVPG-
MUL_2437|M.ulcerans_Agy99 VVLLANHAG----VYLGEDGQDDLFTALNSRAAVVFVHPAELPGPAVPG-
MAB_0299|M.abscessus_ATCC_1997 ASITTSVLG----RSIADPIFDPLYAELNRRRAVLFVHPAGCGAESSLIT
Mvan_0901|M.vanbaalenii_PYR-1 VSTGKPHEHG--YKLLADRYWDPMWAAAQDANLSISFHVGGGNLSRHLND
. . : .
MSMEG_4063|M.smegmatis_MC2_155 YAGNWPGAVQWVFAGPGFG--WHAEAGIHTIRMILSGALDRHPNLKMLSG
MAV_0481|M.avium_104 YAGSWPASVHMMFSGPAFG--WHAEAGIHIVRLILSGALDRHPTLKLLSG
Mb3540c|M.bovis_AF2122/97 ---------------------PLRPSETGRPIPYIDQVALDFPELVIVCG
Rv3510c|M.tuberculosis_H37Rv ---------------------PLRPSETGRPIPYIDQVALDFPELVIVCG
Mflv_0351|M.gilvum_PYR-GCK WEPPYTQN-FMTQSAFRWMVLGHREIADMITALICHGTLTRFPKLRIASV
TH_4037|M.thermoresistible__bu WGGTGTFEGFGKRDPLDNVLLDDRAIHDTMASMIVHQVFTRHPNLKVASI
MMAR_1500|M.marinum_M --------------VAPWAGDFLLDTTRAAHLLVRNGIRQRYPDIKFVLS
MUL_2437|M.ulcerans_Agy99 --------------VAPWAGDFLLDTTRAAHLLVRNGIRQRYPDINFVLS
MAB_0299|M.abscessus_ATCC_1997 ------------DHSLTWSIGAPIEDTVAIMHLIVAGVPSRYPDMKIVTC
Mvan_0901|M.vanbaalenii_PYR-1 ERTSVEG---WRATLARLTTSFFLESGITLADLLMSGVLARYPKLRFVSV
.* : .
MSMEG_4063|M.smegmatis_MC2_155 HWG-EFVAGWLDRLDEVFAWCHH-LDRP--------ISQYYRDHVWITPS
MAV_0481|M.avium_104 HWG-ELAAFYLERLDETLGLLPTGLERA--------PSDYYRQQVWITPS
Mb3540c|M.bovis_AF2122/97 HVG----YPWTEEMVAVARKHENVYIDT--------SAYTIKR-------
Rv3510c|M.tuberculosis_H37Rv HVG----YPWTEEMVAVARKHENVYIDT--------SAYTIKR-------
Mflv_0351|M.gilvum_PYR-GCK ENGSSWIFPLFNDFEELAKKMPQNFGEH--------PLDVFRRNIWVSP-
TH_4037|M.thermoresistible__bu ENGSYFVYRLIKRLKKAANTAPSHFKED--------PVEQLKNNVWIAP-
MMAR_1500|M.marinum_M HAG-GFVPYASHRLALAITADTGRSPAD--------VLEEFSSFYFDTAL
MUL_2437|M.ulcerans_Agy99 HAG-GFVPYASHRLALVITADTGRSPAD--------VLEEFSSFYFDTAL
MAB_0299|M.abscessus_ATCC_1997 HLG-GALPMVLERAHRQVTEWEATQCPE--------APRDAARRLWYDTV
Mvan_0901|M.vanbaalenii_PYR-1 ESAVGWIPFLLESLDFHYKKYEPWLERPEFAGNDMLPSDYFHRQVYAN--
. . .
MSMEG_4063|M.smegmatis_MC2_155 GMFNQNRLKFILAELGHERIIYSEDYPYVESESVSEFLESAE--------
MAV_0481|M.avium_104 GMYNQNQLNFMTAELGAQRIIYSEDFPYVVRDNVSTFLEQAG--------
Mb3540c|M.bovis_AF2122/97 --LPGKLVRFMKTDTGQRKVLFGTNYPMIAHTHALTGLDELG--------
Rv3510c|M.tuberculosis_H37Rv --LPGKLVRFMKTDTGQRKVLFGTNYPMIAHTHALTGLDELG--------
Mflv_0351|M.gilvum_PYR-GCK --FWEGCVSDVVTTVGWDKVMFGSDYPHPEGLPEPKGFWKYAEGMDVRRT
TH_4037|M.thermoresistible__bu --YYEDDVKLLAETIGVDRILFGSDWPHGEGLADPMTFT-----ADIPQF
MMAR_1500|M.marinum_M S-SSAAALPTLIAFAKPGHITFGSDWPFAPTAAGKLFAAGLET------Y
MUL_2437|M.ulcerans_Agy99 S-SSAAALPTLIAFAKPGHITFGSDWPFAPTAAGKLFAAGLET------Y
MAB_0299|M.abscessus_ATCC_1997 GHDHTPALRAAVASLGVDRLIFGSDFPYQAGPRYVSSATYIEEG------
Mvan_0901|M.vanbaalenii_PYR-1 -YWYEDLQPWHVAAIGEDNLMFETDYPHQTCLDKEEIQHSINEG-----L
.: : ::*
MSMEG_4063|M.smegmatis_MC2_155 --LSEDQRASIAHRNAQNLLH---I-------------------------
MAV_0481|M.avium_104 --LSEADTHAIAHTNAEALLR---I-------------------------
Mb3540c|M.bovis_AF2122/97 --LSDEARRDFLHGNAVRVFK---LDPRGKVQT-----------------
Rv3510c|M.tuberculosis_H37Rv --LSDEARRDFLHGNAVRVFK---LDPRGKVQT-----------------
Mflv_0351|M.gilvum_PYR-GCK YDFMGDNARRFMGLPIANPDP---EAARPPALSTA---------------
TH_4037|M.thermoresistible__bu PEFSHEDTRKVMRG--NALTL---LGANVPATA-----------------
MMAR_1500|M.marinum_M PALDAAARGAIDRGSALSLFPRFGVAAPPPQPSAAQRIRHTLSRTAMRGV
MUL_2437|M.ulcerans_Agy99 PALDAAARGAIDRGSALSLFPRFGVAAPPPQPSAAQRIRHTLSRTAMRGV
MAB_0299|M.abscessus_ATCC_1997 --LSAEDASAILDHNGAELLG---LTGV----------------------
Mvan_0901|M.vanbaalenii_PYR-1 SGVSETTKEKILWRNAASLFN---MDIAKLEKLT----------------
. .
MSMEG_4063|M.smegmatis_MC2_155 --------
MAV_0481|M.avium_104 --------
Mb3540c|M.bovis_AF2122/97 --------
Rv3510c|M.tuberculosis_H37Rv --------
Mflv_0351|M.gilvum_PYR-GCK --------
TH_4037|M.thermoresistible__bu --------
MMAR_1500|M.marinum_M ARLMNSGG
MUL_2437|M.ulcerans_Agy99 ARLMNSGG
MAB_0299|M.abscessus_ATCC_1997 --------
Mvan_0901|M.vanbaalenii_PYR-1 --------