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MPEPAPQFRDAPIFDADQHMYETPDALTKFLPDRYTRAVQYGQFGRHTRIVINNRVSDFIPNPTFERVAA PGAHEKFFAGENTEGLTLREMQGPAIEAPAATRNPADRVAELDRQGVREALNYPTLASLIEHATADDPEL TLAVIHALNQWMAEHWTFDYQGRVFSTPIINLSEVDGAQRELEYILTQGARVALIKPGPVNGLRGWRSPA LPEFDPFWRDVESAGLPIVLHASYPPLDDYVGKWEPPYTQNFMTQSAFRWMVLGHREIADMITALICHGT LTRFPKLRIASVENGSSWIFPLFNDFEELAKKMPQNFGEHPLDVFRRNIWVSPFWEGCVSDVVTTVGWDK VMFGSDYPHPEGLPEPKGFWKYAEGMDVRRTYDFMGDNARRFMGLPIANPDPEAARPPALSTA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0351 | - | - | 100% (413) | amidohydrolase 2 |
| M. gilvum PYR-GCK | Mflv_3792 | - | e-104 | 47.50% (400) | amidohydrolase 2 |
| M. gilvum PYR-GCK | Mflv_2524 | - | 7e-90 | 41.88% (382) | amidohydrolase 2 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0299 | - | 6e-06 | 22.07% (299) | putative amidohydrolase (aminocarboxymuconate-semialdehyde |
| M. marinum M | MMAR_3988 | - | 1e-101 | 45.78% (391) | metal-dependent hydrolase |
| M. avium 104 | MAV_1851 | - | 0.0 | 74.69% (407) | amidohydrolase family protein |
| M. smegmatis MC2 155 | MSMEG_2235 | - | 0.0 | 84.28% (407) | amidohydrolase family protein |
| M. thermoresistible (build 8) | TH_0554 | - | 1e-103 | 45.94% (394) | amidohydrolase family protein |
| M. ulcerans Agy99 | MUL_3849 | - | 2e-99 | 45.52% (391) | metal-dependent hydrolase |
| M. vanbaalenii PYR-1 | Mvan_0383 | - | 0.0 | 93.70% (413) | amidohydrolase 2 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0351|M.gilvum_PYR-GCK MPEPAPQFRDAPIFDADQHMYETPDALTKFLPDRYTRAVQYGQFGRHTRI
Mvan_0383|M.vanbaalenii_PYR-1 MTESAEQFRDAPIFDADQHMYETPEALTKHLPQRYSRAVQFANFGRHTRI
MSMEG_2235|M.smegmatis_MC2_155 ---MTEQFTDAPIFDADQHMYETAEALTKFLPERYRRAVQYAQIGRHTRV
MAV_1851|M.avium_104 ---MTTQFTEAPIFDADQHMYETPDALTKFLPDKFRPKVQFVQIGRHTRI
MMAR_3988|M.marinum_M ---MPSRELPFPVFDADNHMYEPQEALTKFLPDKRRHVIDYVQVRGRTKI
MUL_3849|M.ulcerans_Agy99 ---MPSRELPFPVFDADNHMYEPQEALTKFLPDKRKHVIDYVQVRGRTKI
TH_0554|M.thermoresistible__bu ---MSPRSLPYPVFDIDNHMYETTDALIKFLPREHRGKVGYVELNGRKKL
MAB_0299|M.abscessus_ATCC_1997 ----------MTSVRIDIHAHLWSDEYLSLLDGYGR--------------
. . * * : : . *
Mflv_0351|M.gilvum_PYR-GCK VINNRVSDFIPNPTFERVAAPGAHEKFFAGENTEGLTLREMQGPAIEAPA
Mvan_0383|M.vanbaalenii_PYR-1 VINNRVSDFIPNPTFERVAAPGAHEKFFAGENTEGLTLREMQGPAIEAPA
MSMEG_2235|M.smegmatis_MC2_155 VINNRVTDFIPNPTFERVAAPGAHEKFFAGENTEGLTLREMQGKPIEAPA
MAV_1851|M.avium_104 AIRNKITDYMPNPTFERVAAPGAHEKFYSGQNTEGLSMREMSGRGIETPP
MMAR_3988|M.marinum_M VVRGQISDYIPNPTFEVVARPGAQEEYFR-NGSRGKSYREVMGEPMKAIP
MUL_3849|M.ulcerans_Agy99 VVRGQISDYIPNPTFEVVARPGAQEEHFR-NGSGGKSYREVMGEPMKAIP
TH_0554|M.thermoresistible__bu MVKDRISHMIPNPTFEKVARPGSAEDYFLGNNPEGLNFREFVGEPMEVIP
MAB_0299|M.abscessus_ATCC_1997 ------PATDVHRGLGAGATRDDLDG------------------------
. : : * . :
Mflv_0351|M.gilvum_PYR-GCK ATRNPADRVAELDRQGVREALNYPTLASLIEHATADDPELTLAVIHALNQ
Mvan_0383|M.vanbaalenii_PYR-1 ATRNPADRVAELDRQGVREALNYPTLASLIEHATADDPELTLAVIHALNQ
MSMEG_2235|M.smegmatis_MC2_155 ATRNPEDRIAELDRQGVVEALIYPTLGSLVEHSSADDPQLTLAIIHALNE
MAV_1851|M.avium_104 AARNPEDRIAELDRQGVDACLNYPTLANLVEHASAEDPDLTVAIIHALNQ
MMAR_3988|M.marinum_M AFREPGPRLEVMDELGLDYALMFPTLASLVEERMKDDPEMTHDVIHALNQ
MUL_3849|M.ulcerans_Agy99 AFREPGPRLEVMDELGLDYALMFPTLASLVEERMKDDPEMTHDVIHALNQ
TH_0554|M.thermoresistible__bu AFQHPAPRLELMDELGIDRCVMYPTLASLIEERTTDDVVLTHAVMHALNQ
MAB_0299|M.abscessus_ATCC_1997 -------RFELMDEAGVDLQILTATPASPHFEDQAAAVASARFINDEY--
*. :*. *: : .* .. . : : .
Mflv_0351|M.gilvum_PYR-GCK WMAEHWTFDYQGRVFSTPIINLSEVDGAQRELEYILTQGARVALIKPGPV
Mvan_0383|M.vanbaalenii_PYR-1 WMLEHWGFDYQGRVFSTPIINLSEVDGAQRELDYVLTHGAKVALIKPGPV
MSMEG_2235|M.smegmatis_MC2_155 WILEHWTFNHADRLFTTPIINLSEVEAAQRELAWILEHGAKAALIKPGPV
MAV_1851|M.avium_104 WMLEHWGFTYANRIYSTPVLNLGLVDEARRELEYILENGAKVALIKPAPV
MMAR_3988|M.marinum_M WMYETWSFNYKDRIFATPVITLPIVDRALEELEWCLQRGARTVLVRPAPV
MUL_3849|M.ulcerans_Agy99 WMYETWSFNYKDRIFATPVITLPIVDRALEELEWCLQRGARTVLVRPAPV
TH_0554|M.thermoresistible__bu WMHEHWSFDYEGRIFATPVITLPIVEEAIRELHWCLERGMRTFLVRPAPV
MAB_0299|M.abscessus_ATCC_1997 ---AKLSSEYPGRFGALASLPLPHVPAALEELARAIDELGMYGASITTSV
: .*. : . : * * * .** : . . .*
Mflv_0351|M.gilvum_PYR-GCK NG-LRGWRSPALPEFDPFWRDVESAGLPIVLHASYPPLDDYVGKWEPPYT
Mvan_0383|M.vanbaalenii_PYR-1 NG-LRGWRSPALPEFDPFWRDVEAAGLPIVLHASYPPLDDYVGKWEPPHT
MSMEG_2235|M.smegmatis_MC2_155 NG-LHGWRSPALPEFDPFWRDVEAAGLPIVLHASFPPLDDYINKWEPAHT
MAV_1851|M.avium_104 YG-YKGWRSPALPEFDPFWRDVEDAGLPIVLHASQPPLQEYIEKWEPADT
MMAR_3988|M.marinum_M PG-YRGSRSFGFEEFDPFWQACIKAGIPVSMHASDSGYSEFLNVWEPGDE
MUL_3849|M.ulcerans_Agy99 PG-YRGSRSFGFKEFDPFWQACIKAGIPVSMHASDSGYSEFLNVWEPGDE
TH_0554|M.thermoresistible__bu PSRFGGSRSMGLPEFDPFWQEVVNAGIPVTMHASDSGYQKHLMEWEGGDE
MAB_0299|M.abscessus_ATCC_1997 LG-----RSIADPIFDPLYAELNRRRAVLFVHPAG-----------CGAE
. ** . ***:: : :*.:
Mflv_0351|M.gilvum_PYR-GCK QNFMTQSAFRWMVLGHREIADMITALICHGTLTRFPKLRIASVENGSSWI
Mvan_0383|M.vanbaalenii_PYR-1 QNFMAMSAFRWMVLGHREIADMITSLICHGTLTRFPKLRIASVENGSSWI
MSMEG_2235|M.smegmatis_MC2_155 QNFMTQSAFRWMVLGHREIADMLTALICHGTLTRFPRLRIASVENGSSWI
MAV_1851|M.avium_104 ANAFEMSAFKWTALGHREIADMITSLICHGTLTRFPKLRIASVENGSAWI
MMAR_3988|M.marinum_M FLPFKPTAFRMLAMGKRPIEDAMGALVCHGALSRNPELRILSIENGADWV
MUL_3849|M.ulcerans_Agy99 FLPFKPTAFRMLAMSKRPIEDAMGALVCHGALSRNPELRILSIKNGADWV
TH_0554|M.thermoresistible__bu YLSFKPSALREVVMGHRAIEDTLAAMICHGALSRFPDLKILCVENGSGWV
MAB_0299|M.abscessus_ATCC_1997 SSLITDHSLTWSIGAPIEDTVAIMHLIVAGVPSRYPDMKIVTCHLGGALP
: :: . : :: *. :* * ::* . *.
Mflv_0351|M.gilvum_PYR-GCK FPLFNDFEELAKKMPQNFGEHPLDVFRRNIWVSP--FWEGCVSDVVTTVG
Mvan_0383|M.vanbaalenii_PYR-1 FPLFNDFDELAKKMPQNFGEHPLDVFRRNIWVSP--FWEGCVSDVVNTVG
MSMEG_2235|M.smegmatis_MC2_155 FPLFRDFADLYKKMPQNFPEHPHDVFRRNIWVSP--FWEGCVADVVETVG
MAV_1851|M.avium_104 KPLFDDLEMTYKKMPQNFPEHPHDVFRRNCWVSP--FWEGSVADVVETVG
MMAR_3988|M.marinum_M PTLFKGLKGVYKKMPNAFMEDPIEAFKRCVYISP--FWEDRFAEIVKMVG
MUL_3849|M.ulcerans_Agy99 PTLFKGLKGVYKKMPNAFMEDPIEAFKRCVYISP--FWEDRFVEIVKMVG
TH_0554|M.thermoresistible__bu RNLLEQLDTAYRIMPKEFDEHPVEVFKRNIYIHP--FLEDDVPGLIEIMG
MAB_0299|M.abscessus_ATCC_1997 MVLERAHRQVTEWEATQCPEAPRDAARRLWYDTVGHDHTPALRAAVASLG
* . . * * :. :* : . : :*
Mflv_0351|M.gilvum_PYR-GCK WDKVMFGSDYPHPEGLPEPKGFWKYAEGMDVRRTYDFMGDNARRFMGLPI
Mvan_0383|M.vanbaalenii_PYR-1 WDKVMFGSDYPHPEGLAEPKGFWKYAEGMDVRRTYDFMGDNARRFMGLPI
MSMEG_2235|M.smegmatis_MC2_155 WDKVLFGSDYPHPEGLAEPKGFWKYAEGMDIRRTYDFMGDNARRFMGLPI
MAV_1851|M.avium_104 WDRVLFGSDWPHPEGLAEPKRYWQYAEGMDKRRTYDFMGDNARRFMGLPI
MMAR_3988|M.marinum_M TDRVVFGSDWPHPEGLKDPISFVDELAGFPPEDVAKIMGGNMMEVMKIGT
MUL_3849|M.ulcerans_Agy99 TDRVVFGSDWPHPEGLKDPISFVDELAGFPPEDVAKIMGGNMMDVMKIGT
TH_0554|M.thermoresistible__bu ADHVLFGSDYPHPEGIGDPLSFVDRLEGVSEADKAKIMGGNAMGLLGIRV
MAB_0299|M.abscessus_ATCC_1997 VDRLIFGSDFPYQAGPRYVSSATYIEEGLSAEDASAILDHNGAELLGLTG
*:::****:*: * *. ::. * .: :
Mflv_0351|M.gilvum_PYR-GCK ANPDPEAARPPALSTA-
Mvan_0383|M.vanbaalenii_PYR-1 ANPDPAAARPPALTTA-
MSMEG_2235|M.smegmatis_MC2_155 ANPDPDAVKPPALTASS
MAV_1851|M.avium_104 ANPDPDAVKPPALVNA-
MMAR_3988|M.marinum_M PAPQPVNA---------
MUL_3849|M.ulcerans_Agy99 AAPKPVNA---------
TH_0554|M.thermoresistible__bu PA---------------
MAB_0299|M.abscessus_ATCC_1997 V----------------