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PVSRAERREKLLRAAQSAVMKHGVDVQLKQVAAEAGLTPSAVLYHFPDIQTLLIEANRAGIERFYDARLR AVAGDAPPDRKLVTTIESGLPVDADDPDVKLMCALGGAAARHPAYAVMLTALYDRQVAMYQVILESGAAQ GIFALTSSSLAVARNIVALEDAYGYRMVARHPSLDVDTAVDLICDYARVATGHPLPRPVRT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5332 | - | - | 100% (202) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_1506 | - | 1e-30 | 39.59% (197) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_6537 | - | 4e-06 | 26.37% (182) | transcriptional regulator, TetR family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1998c | - | 5e-05 | 31.11% (90) | transcriptional regulatory protein |
| M. gilvum PYR-GCK | Mflv_0364 | - | 1e-05 | 26.45% (121) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv1963c | mce3R | 5e-05 | 31.11% (90) | transcriptional repressor (probably TETR-family) MCE3R |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4765 | - | 3e-05 | 31.71% (82) | putative regulatory protein TetR |
| M. marinum M | MMAR_4832 | - | 5e-07 | 28.00% (150) | TetR family transcriptional regulator |
| M. avium 104 | MAV_0367 | - | 3e-07 | 27.27% (165) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_2883 | - | 4e-06 | 33.80% (71) | PUTATIVE putative transcriptional regulator, TetR family |
| M. ulcerans Agy99 | MUL_2880 | mce3R | 3e-05 | 30.39% (102) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_3360 | - | 6e-06 | 32.65% (98) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1998c|M.bovis_AF2122/97 ------MASVAQPVRRRPKDRKKQILDQAVGLFIERGFHSVKLEDIAEAA
Rv1963c|M.tuberculosis_H37Rv ------MASVAQPVRRRPKDRKKQILDQAVGLFIERGFHSVKLEDIAEAA
MUL_2880|M.ulcerans_Agy99 ------MDSVVAPVRRRPKDRKQQILEQAVGLFIDRGFHSVKLEDIAEAA
Mflv_0364|M.gilvum_PYR-GCK ----MRSRGWSGQWPASDEEAITRILDAADELVAADASVLRIAD-VARAL
MAB_4765|M.abscessus_ATCC_1997 ---MARRRGWDGQPPSSDEEAAERIVAAAVKLIGETGSAVSLAD-VAAEL
MAV_0367|M.avium_104 --MT-----RRPHPG--DSTTRDLLIDATIKVMVEDGYAAATSRRVAAEA
TH_2883|M.thermoresistible__bu --MSSSSPSRRSRVGGSDTATRRALIKATADVMLEEGYAAATSRRVAARA
MSMEG_5332|M.smegmatis_MC2_155 -------------MPVSRAERREKLLRAAQSAVMKHG-VDVQLKQVAAEA
MMAR_4832|M.marinum_M --------------MRKIPAQISERLPAAAELFAERGLNDTKIEDVAATT
Mvan_3360|M.vanbaalenii_PYR-1 MEAEKRRRGRPTGSRVDPGERRALLLDAAERAIRANG-PDVGLGDVAAEA
: : . . :*
Mb1998c|M.bovis_AF2122/97 GVTARALYRHYDNKQALLAEAIRTGQDQYQSARRLTEGETEPTPRPLNAD
Rv1963c|M.tuberculosis_H37Rv GVTARALYRHYDNKQALLAEAIRTGQDQYQSARRLTEGETEPTPRPLNAD
MUL_2880|M.ulcerans_Agy99 GVTARALYRHYDNKQALLAEAIRTGQDQYQSARRLTEGEQEPTPRPLSVD
Mflv_0364|M.gilvum_PYR-GCK GVTRQTVYRYFPHPEAIRLACAMRAADGFF--------------------
MAB_4765|M.abscessus_ATCC_1997 GVIRQTVYRYFPTADALMHAASLASVDGFL--------------------
MAV_0367|M.avium_104 GVKPALVHYYFPTMDELYLDVFRRGAAAYQ--------------------
TH_2883|M.thermoresistible__bu GVKPALVHYYFPSMDDLFVAVFRAGAEATL--------------------
MSMEG_5332|M.smegmatis_MC2_155 GLTPSAVLYHFPDIQTLLIEANRAGIERFY--------------------
MMAR_4832|M.marinum_M GIAKATLYYYFAGKEEILAFLLEDVLQHVA--------------------
Mvan_3360|M.vanbaalenii_PYR-1 GFVRSAVYAMYPNRDALLAALSERTAQRLL--------------------
*. : : : :
Mb1998c|M.bovis_AF2122/97 LEDLIAAAVASRALTVLWQREARYLNEDDRTAVRRRINAIVAGMRDSVLL
Rv1963c|M.tuberculosis_H37Rv LEDLIAAAVASRALTVLWQREARYLNEDDRTAVRRRINAIVAGMRDSVLL
MUL_2880|M.ulcerans_Agy99 LPDLIAAAVASRSLTVLSQREARYLNDADRIEVRRRINAIVAGMRESVLL
Mflv_0364|M.gilvum_PYR-GCK ----------------------------------DRLAKQVGGMTDPVAV
MAB_4765|M.abscessus_ATCC_1997 ----------------------------------DRLTHVVRGITDPAEA
MAV_0367|M.avium_104 ----------------------------------ERQTRALTSDRP----
TH_2883|M.thermoresistible__bu ----------------------------------QRQRNAFAGDRP----
MSMEG_5332|M.smegmatis_MC2_155 ----------------------------------DARLRAVAGDAPPDRK
MMAR_4832|M.marinum_M ----------------------------------DEVTAIVEADGTAAQR
Mvan_3360|M.vanbaalenii_PYR-1 ----------------------------------ADITRRAEGSSDLRQR
.
Mb1998c|M.bovis_AF2122/97 EVPDLSPQHSELRAWAVSS-TLTSLGRHSLSLPGEELKKLLYQACMAAAR
Rv1963c|M.tuberculosis_H37Rv EVPDLSPQHSELRAWAVSS-TLTSLGRHSLSLPGEELKKLLYQACMAAAR
MUL_2880|M.ulcerans_Agy99 EVPGLSPAHSELRAWAVSS-TLTSLGRHSLTLPAEELKERLYQACMAAAR
Mflv_0364|M.gilvum_PYR-GCK MVECVASAVERLAGDPQFE-ALVTARRHGARAV-----------------
MAB_4765|M.abscessus_ATCC_1997 LTEGVLYTLEEVTRTPHLG-IMMSEPYAHSHTS-----------------
MAV_0367|M.avium_104 -LHALWDTLIEPKDTRLLL-EFMGLANHRKAIR-----------------
TH_2883|M.thermoresistible__bu -LHALWE-LNSTQGAQLFM-EFMALGNHRKAIR-----------------
MSMEG_5332|M.smegmatis_MC2_155 LVTTIESGLPVDADDPDVK-LMCALGGAAARHP-----------------
MMAR_4832|M.marinum_M LHTVINAQLRVMAQRPAVCRALIGELGRAARMP-----------------
Mvan_3360|M.vanbaalenii_PYR-1 MALFFDVVCGWIAAEPDVHRALNSDPATGVFEQ-----------------
. :
Mb1998c|M.bovis_AF2122/97 TPPVCELPPLPAGDAARDEADVLFSRYETLLAAGARLFRAQGYPAVNTSE
Rv1963c|M.tuberculosis_H37Rv TPPVCELPPLPAGDAARDEADVLFSRYETLLAAGARLFRAQGYPAVNTSE
MUL_2880|M.ulcerans_Agy99 TPPVCELEPLGTAAGGRDGQDVLFSRYETLLATGARLFRAQGYPAVSTSE
Mflv_0364|M.gilvum_PYR-GCK ----------------SLTSDTALTFARTILHRFDIDWEQHGFDTAGLDR
MAB_4765|M.abscessus_ATCC_1997 ----------------DMTSDEAQAFGLRMLDRFDVDWVQYGYDDAAKRE
MAV_0367|M.avium_104 ----------------AELAAWFGRWRDTQITALNSIVREHDMDAGEFPP
TH_2883|M.thermoresistible__bu ----------------REIAAYAEQYGELEHAAVATALRAHGMDTEEFPP
MSMEG_5332|M.smegmatis_MC2_155 --------------AYAVMLTALYDRQVAMYQVILESGAAQGIFALTSSS
MMAR_4832|M.marinum_M -------------AIADMITTAYFEPVETLLRAGAADGSLVALDKPRAAA
Mvan_3360|M.vanbaalenii_PYR-1 --------------LAAAVEFMLTAAFAADARAPASAPWSRAIVGSAVSA
Mb1998c|M.bovis_AF2122/97 IGKGAGIAGPGLYRSFSSKQAILDALIRRLDEWRCLECIRALRANQQAAQ
Rv1963c|M.tuberculosis_H37Rv IGKGAGIAGPGLYRSFSSKQAILDALIRRLDEWRCLECIRALRANQQAAQ
MUL_2880|M.ulcerans_Agy99 IGKGAGIAGPGLYRSFSSKQAILDALIRRLDEWRSLECIRALRANRQAAQ
Mflv_0364|M.gilvum_PYR-GCK LAELSIRTVHS---ILVDP-----------------------GDPAREGA
MAB_4765|M.abscessus_ATCC_1997 LVEFALRIMLS---FFVSP-----------------------NEATRSRD
MAV_0367|M.avium_104 AGIAVILAAIGRMLILEDA-----------------------LGATAGHD
TH_2883|M.thermoresistible__bu AAIAMILTSVARIMLIEQN-----------------------LGIERSHA
MSMEG_5332|M.smegmatis_MC2_155 LAVARNIVALEDAYGYRMVA----------------------RHPSLDVD
MMAR_4832|M.marinum_M IALFGAVTISALTYLITDDALN--------------------EELIARTI
Mvan_3360|M.vanbaalenii_PYR-1 AEWWCRTGTMTRAELVEHLT-----------------------ALCWDGG
Mb1998c|M.bovis_AF2122/97 RLRGLVQGHVRISLDAPDLVAVSVTELSHASVEVRDGYLRNQGDREAVWI
Rv1963c|M.tuberculosis_H37Rv RLRGLVQGHVRISLDAPDLVAVSVTELSHASVEVRDGYLRNQGDREAVWI
MUL_2880|M.ulcerans_Agy99 RLRGLVEGHVRISLDAPDLVAVCATELNHASGDVRDGYLRNQADRDTLWI
Mflv_0364|M.gilvum_PYR-GCK ELRRFVAGWLGPAILYPRLARAVDAITAPGVSPASPMRY-----------
MAB_4765|M.abscessus_ATCC_1997 ELRGFLKRWLG------------GAVLAQGR-------------------
MAV_0367|M.avium_104 AAVALVNRFID------------RFELP----------------------
TH_2883|M.thermoresistible__bu AVREFVGRYLD------------RFDVPAGAHDADS--------------
MSMEG_5332|M.smegmatis_MC2_155 TAVDLICDYAR---------VATGHPLPRPVRT-----------------
MMAR_4832|M.marinum_M HDVAFIGLRPR---------------------------------------
Mvan_3360|M.vanbaalenii_PYR-1 AALPFVDDDIK------------AIDIRRP--------------------
::
Mb1998c|M.bovis_AF2122/97 DLIGKLVPATSVAQGRLLVAAAISFIEDVARTWHLTRYAGVADEISGLAL
Rv1963c|M.tuberculosis_H37Rv DLIGKLVPATSVAQGRLLVAAAISFIEDVARTWHLTRYAGVADEISGLAL
MUL_2880|M.ulcerans_Agy99 DLIGELVPQTSSVEARLLVAAAISFIEDVARTWHLTRYAAVADEITEIAL
Mflv_0364|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4765|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_0367|M.avium_104 --------------------------------------------------
TH_2883|M.thermoresistible__bu --------------------------------------------------
MSMEG_5332|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_4832|M.marinum_M --------------------------------------------------
Mvan_3360|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1998c|M.bovis_AF2122/97 AILTSGAGNLLRA
Rv1963c|M.tuberculosis_H37Rv AILTSGAGNLLRA
MUL_2880|M.ulcerans_Agy99 SILTSRS------
Mflv_0364|M.gilvum_PYR-GCK -------------
MAB_4765|M.abscessus_ATCC_1997 -------------
MAV_0367|M.avium_104 -------------
TH_2883|M.thermoresistible__bu -------------
MSMEG_5332|M.smegmatis_MC2_155 -------------
MMAR_4832|M.marinum_M -------------
Mvan_3360|M.vanbaalenii_PYR-1 -------------