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MALTLDTYRLLGRSGLRVSPLALGSATFGTDWGWGAERDDARKLFDLYVERGGNFIDTANTYTDGSSERL LGEFTQNNRESLVLATKYTTQRRPGDPNSAGASRKSLVASVDASLRQLRTDYLDLLFLHVWDFATPVEEI LRGMDDLVRQGKILYVGISNAPAWQVSRMQAIADLRGWSPLVALQIEYSLIERTGERDLIPMAREMGLGV TPYSPLGGGVLTGKYRRDDLTASHLASEGSTRGSFNAALGTVTERNIAIADVLKDVAAELGCTSAQAGLA WMLQNPDITAPVIGARTPAQLEENLGALDIDLAEDHLARLDEASAIDLGYPHQMLASDHIRNVTGGS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1304 | - | - | 100% (347) | rhizopine catabolism protein |
| M. smegmatis MC2 155 | MSMEG_4654 | - | 2e-82 | 46.13% (336) | aldo/keto reductase |
| M. smegmatis MC2 155 | MSMEG_1751 | - | 7e-64 | 42.90% (331) | norsolorinic acid reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2320 | - | 3e-25 | 31.33% (316) | hypothetical protein Mb2320 |
| M. gilvum PYR-GCK | Mflv_0942 | - | 3e-16 | 25.72% (311) | aldo/keto reductase |
| M. tuberculosis H37Rv | Rv2298 | - | 3e-25 | 31.33% (316) | hypothetical protein Rv2298 |
| M. leprae Br4923 | MLBr_00458 | - | 1e-22 | 28.21% (312) | putative oxidoreductase |
| M. abscessus ATCC 19977 | MAB_4120c | - | 1e-40 | 34.86% (284) | aldo/keto reductase |
| M. marinum M | MMAR_3520 | - | 2e-27 | 31.33% (332) | hypothetical protein MMAR_3520 |
| M. avium 104 | MAV_2496 | - | 1e-43 | 35.81% (310) | aldo/keto reductase |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_2745 | - | 6e-27 | 31.02% (332) | hypothetical protein MUL_2745 |
| M. vanbaalenii PYR-1 | Mvan_2555 | - | 1e-21 | 28.23% (294) | aldo/keto reductase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3520|M.marinum_M ----------------------MKHLEVDGIGNVSRIGLGTWQFGSRE--
MUL_2745|M.ulcerans_Agy99 ----------------------MKHLEVDGIGNVSRIGLGTWQFGSRE--
Mb2320|M.bovis_AF2122/97 ----------------------MKYLDVDGIGQVSRIGLGTWQFGSRE--
Rv2298|M.tuberculosis_H37Rv ----------------------MKYLDVDGIGQVSRIGLGTWQFGSRE--
MLBr_00458|M.leprae_Br4923 MRRFWRTVVEVTSQNSQALAQASGAFTLGGDLKVNRLGFGAMRLTGKG--
Mvan_2555|M.vanbaalenii_PYR-1 ----------MTSGSS----RTAPTFLLGGELPVNRLGFGAMRLTGPG--
Mflv_0942|M.gilvum_PYR-GCK ----------MTTAIQ-------TTLTLGGELPVPRMGYGAMQLAGPG--
MAB_4120c|M.abscessus_ATCC_199 -----------------------MKHTWLGELSVSRIGLGAMSMSAYYRA
MAV_2496|M.avium_104 -----------------------MKQAQLGGLQVGRLGLGAMGMSVAY--
MSMEG_1304|M.smegmatis_MC2_155 ---------------------MALTLDTYRLLGRSGLRVSPLALGSATFG
: .. :
MMAR_3520|M.marinum_M WGYGDRYASGAARDIVARARALGVTLFDTAEVYGLGKSERILGEALGDER
MUL_2745|M.ulcerans_Agy99 WGYGDRYASGAARDIVARACALGVTLFDTAEVYGLGKSERILGEALGDER
Mb2320|M.bovis_AF2122/97 WGYGDRYATGAARDIVKRARALGVTLFDTAEIYGLGKSERILGEALGDDR
Rv2298|M.tuberculosis_H37Rv WGYGDRYATGAARDIVKRARALGVTLFDTAEIYGLGKSERILGEALGDDR
MLBr_00458|M.leprae_Br4923 -VWGPPVDRYEAVRVLRRAVELGVNFIDTADSYGPYVSEEIIAEAL-HPY
Mvan_2555|M.vanbaalenii_PYR-1 -VWGPPADRDECLRVLRRAVDLGVDFIDTADSYGPYISEDLIREAL-HPY
Mflv_0942|M.gilvum_PYR-GCK -VLGLPDDVDNAVDVLRRAVDHGVRFFDTANAYGPRTVNQIIGRALGTPA
MAB_4120c|M.abscessus_ATCC_199 IGSESGPDEATSIDTLRRALDLGVSLIDTAEIYGPFVNEELVGRAIAGRR
MAV_2496|M.avium_104 --AGAGTDDAESIRTVHRAIELGVTLIDTAEVYGPYINEELLARALRGRR
MSMEG_1304|M.smegmatis_MC2_155 TDWGWGAERDDARKLFDLYVERGGNFIDTANTYTDGSSERLLGEFTQNNR
. . * ::***: * : :: .
MMAR_3520|M.marinum_M AEVVVASKI----------MPVAPFPAVVKQRERASARRLQLDRIPLYQI
MUL_2745|M.ulcerans_Agy99 AEVVVASKI----------MPVAPFPAVVKQRERASARRLQLDRIPLYQI
Mb2320|M.bovis_AF2122/97 TEVVVASKV----------FPVAPFPAVIKNRERASARRLQLNRIPLYQI
Rv2298|M.tuberculosis_H37Rv TEVVVASKV----------FPVAPFPAVIKNRERASARRLQLNRIPLYQI
MLBr_00458|M.leprae_Br4923 KGLVIATKAGLLRTGRDVWIPL-GNPSYLRQELEMSLRRLNVDTIDLFQL
Mvan_2555|M.vanbaalenii_PYR-1 DGVVIATKAGLLRTAPDVWEPL-GFPAYLRQECEMSLRRLGTDTIDLFQL
Mflv_0942|M.gilvum_PYR-GCK DDLVIGNKVGAVRGPAGEWLQD-SRPEILRTQVEEALLDMRADASALTYL
MAB_4120c|M.abscessus_ATCC_199 DEVVLATKFGLVSHGNGASQVLDSTPGNISTAVEGSLRRLGVDHIDLYYQ
MAV_2496|M.avium_104 DRVVLATKFGLISHTG--RDGLDSSPANIRVAVDGSLRRLATDHIDLYYQ
MSMEG_1304|M.smegmatis_MC2_155 ESLVLATKYTTQRRPGD-PNSAGASRKSLVASVDASLRQLRTDYLDLLFL
:*:..* : : : : *
MMAR_3520|M.marinum_M HQPNPV---------VPDSVIMPGMRELLDTGRIGAAGVSNYSLARWKKA
MUL_2745|M.ulcerans_Agy99 HQPNPV---------VPDSVIMPGIRELLDIGRIGAAGVSNYSLARWKKA
Mb2320|M.bovis_AF2122/97 HQPNPV---------VPDSVIMPGMRDLLDSGDIGAAGVSNYSLARWRKA
Rv2298|M.tuberculosis_H37Rv HQPNPV---------VPDSVIMPGMRDLLDSGDIGAAGVSNYSLARWRKA
MLBr_00458|M.leprae_Br4923 HRIDPN---------FPLADQVGELFTLKNEGKIRHIGLSEINLDQLTAA
Mvan_2555|M.vanbaalenii_PYR-1 HRIAPK---------FPAEDQIGELAKLQQEGKVRHIGLSEVSVDQLTAA
Mflv_0942|M.gilvum_PYR-GCK RLAGDIRGVGEGPGEVPLEESLGALVELRDQGKIRHIGLSGASPAALERA
MAB_4120c|M.abscessus_ATCC_199 HRVDPN---------VAIEDTIGAVAELVQQGKVRYIGLSEAAAGTIRRA
MAV_2496|M.avium_104 HRLDRQ---------TPIEDTVGALAELVAAGKIRHIGLSEVGVNSIRRA
MSMEG_1304|M.smegmatis_MC2_155 HVWDFA---------TPVEEILRGMDDLVRQGKILYVGISNAPAWQVSRM
: . : : * * : *:*
MMAR_3520|M.marinum_M DAALGR----PVVSNQVHFSLAHPGPLDDLVPFAERENRIIIAYSPLAQG
MUL_2745|M.ulcerans_Agy99 DAALGR----PVVSNQVHFSLAHPGPLDDLVPFAERENRIIIAYSPLAQG
Mb2320|M.bovis_AF2122/97 DAALGR----PVVSNQVHFSLAHPDALEDLVPFAELENRIVIAYSPLAQG
Rv2298|M.tuberculosis_H37Rv DAALGR----PVVSNQVHFSLAHPDALEDLVPFAELENRIVIAYSPLAQG
MLBr_00458|M.leprae_Br4923 QQIT------EIVSVQNMYNLSARA-AEPLLDAVTSRGIGFIPWSPLAAG
Mvan_2555|M.vanbaalenii_PYR-1 RAVA------PIVSVQNMYNLTMRA-AEPVLDACEADGIAFIPWFPLAAG
Mflv_0942|M.gilvum_PYR-GCK QQIT------TIAAVQNRFNLIDRS-GVEVLAACERDGIAFVPYFPLATG
MAB_4120c|M.abscessus_ATCC_199 HAVH------PITALQNEYSLWTRDIEDEILPTIRELGIGLVAYSPLGRG
MAV_2496|M.avium_104 HAVH------PITAVQSEYSLWTRDQEDEILPVLRELGIGFVAYSPLGRG
MSMEG_1304|M.smegmatis_MC2_155 QAIADLRGWSPLVALQIEYSLIERTGERDLIPMAREMGLGVTPYSPLGGG
:.: * :.* :: . . .: **. *
MMAR_3520|M.marinum_M LLGGKYGVDNR-------PAGVRAVNPLFGTENLRRIEPLLQTLRAVATD
MUL_2745|M.ulcerans_Agy99 LLGGKYGVDNR-------PAGVRAVNPLFGTENLRRIEPLLQTLRAVAID
Mb2320|M.bovis_AF2122/97 LLGGKYGLENR-------PGGVRALNPLFGTENLRRIEPLLATLRAIAVD
Rv2298|M.tuberculosis_H37Rv LLGGKYGLENR-------PGGVRALNPLFGTENLRRIEPLLATLRAIAVD
MLBr_00458|M.leprae_Br4923 PLAAPDGPLQ-----------------------------------RIAVN
Mvan_2555|M.vanbaalenii_PYR-1 PLAAADGPLH-----------------------------------RIAAE
Mflv_0942|M.gilvum_PYR-GCK GLGD-DDELR-----------------------------------RPGER
MAB_4120c|M.abscessus_ATCC_199 FLTGAIGSRDQLA-----EGDFRREQPRFSAENFDANLALVEEVRSVASS
MAV_2496|M.avium_104 FLTGAIRSAHELP-----DTDYRRTNPRFAEQNFAHNLRCADELRDIAAD
MSMEG_1304|M.smegmatis_MC2_155 VLTGKYRRDDLTASHLASEGSTRGSFNAALGTVTERNIAIADVLKDVAAE
* .
MMAR_3520|M.marinum_M VDAKPAQVALAWLIS-LPGVVAIPGASSVEQLEFNVAAADIE--LSADAR
MUL_2745|M.ulcerans_Agy99 VDAKPAQVALAWLIS-LPGVVAIPGASSVEQLEFNVAAADIE--LSADAR
Mb2320|M.bovis_AF2122/97 VDAKPAQVALAWLIS-LPGVVAIPGASSVEQLEFNVAAADIE--LSAQSR
Rv2298|M.tuberculosis_H37Rv VDAKPAQVALAWLIS-LPGVVAIPGASSVEQLEFNVAAADIE--LSAQSR
MLBr_00458|M.leprae_Br4923 HHATPSQLALAWLLKRSPVMLPIPGTSRVAHLEENVAAAEIS--LSDDEF
Mvan_2555|M.vanbaalenii_PYR-1 HHATPSQLALAWLLKRSPVMLPIPGTSKVAHLEENVAAAQID--LTDAEF
Mflv_0942|M.gilvum_PYR-GCK LGVPMSTIALAWLLRRSPVIVPIPGTKSVAHLRDNLSAAQVADQLTEDEV
MAB_4120c|M.abscessus_ATCC_199 IGATSAQVALAWLLARGDDIVPIPGTTKVSRVNENVGAVDIE--LLPEHL
MAV_2496|M.avium_104 VGATPAQVALAWLLAKGPDIVPIPGTKRVARLEENVGADALE--LTTEQL
MSMEG_1304|M.smegmatis_MC2_155 LGCTSAQAGLAWMLQNPDITAPVIGARTPAQLEENLGALDID--LAEDHL
: .***:: .: *: ::. *:.* : *
MMAR_3520|M.marinum_M AALTEAARAFHPVSARRFLTDTVREKLGRR--------
MUL_2745|M.ulcerans_Agy99 AALTEAARAFHPVSARRFLTDTVREKLGRR--------
Mb2320|M.bovis_AF2122/97 DALTDAARAFRPVSTGRFLTDMVREKVSRR--------
Rv2298|M.tuberculosis_H37Rv DALTDAARAFRPVSTGRFLTDMVREKVSRR--------
MLBr_00458|M.leprae_Br4923 EMLSAAGAQ-----------------------------
Mvan_2555|M.vanbaalenii_PYR-1 ETLGNAGAAAS---------------------------
Mflv_0942|M.gilvum_PYR-GCK HALTAVEDEQSATLSTMPSRMTDAFARVVSPPGSGRRR
MAB_4120c|M.abscessus_ATCC_199 VRLECLAAAAGDRYNAEHLARLEG--------------
MAV_2496|M.avium_104 SRLDRLTPPVGGHHADAQLAWIDR--------------
MSMEG_1304|M.smegmatis_MC2_155 ARLDEASAIDLGYPHQMLASDHIRNVTGGS--------
*