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TLDQYVTLGRSGLRVSPFALGAMTFGEDFGAVGTSVENSERILSAYLDRGGNFIDTANFYTNGHSEKILG DFFARTPGRRQHVVLASKFFGNMFPGDPNGGGAGRSSVLHQLHDTLRRLQTDYLDVYWLHNWDRNTPIEE TMRTLDDLVRAGTVRYIGFSNTPAWVTAQAQTMAMLRGWTPLIALQVEYSLLARTVESEVAPFAQDQGIA LVPWSPLKNGFLSGKYRRDSAAVDSARAAFVGGGPSESDFDVIEAVAGIADELETSSAAVALAWLRARPG TVVPIIGARRMEHLESNVEALGVELTSEQLKLLDEVSAPVLSYPAEVNGEVRASLQFAGTTVDGETSTVF PALLAGDARY*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4654 | - | - | 100% (361) | aldo/keto reductase |
| M. smegmatis MC2 155 | MSMEG_1304 | - | 2e-82 | 46.13% (336) | rhizopine catabolism protein |
| M. smegmatis MC2 155 | MSMEG_5192 | - | 4e-52 | 38.91% (329) | aldo/keto reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2320 | - | 7e-20 | 29.35% (310) | hypothetical protein Mb2320 |
| M. gilvum PYR-GCK | Mflv_0942 | - | 6e-13 | 25.74% (338) | aldo/keto reductase |
| M. tuberculosis H37Rv | Rv2298 | - | 7e-20 | 29.35% (310) | hypothetical protein Rv2298 |
| M. leprae Br4923 | MLBr_00458 | - | 8e-23 | 31.11% (315) | putative oxidoreductase |
| M. abscessus ATCC 19977 | MAB_4120c | - | 6e-38 | 35.42% (319) | aldo/keto reductase |
| M. marinum M | MMAR_2086 | - | 3e-23 | 31.65% (316) | oxidoreductase |
| M. avium 104 | MAV_2496 | - | 3e-40 | 35.11% (319) | aldo/keto reductase |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_2745 | - | 6e-21 | 30.00% (310) | hypothetical protein MUL_2745 |
| M. vanbaalenii PYR-1 | Mvan_2555 | - | 2e-19 | 30.10% (309) | aldo/keto reductase |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_4120c|M.abscessus_ATCC_199 -----------------------MKHTWLGELSVSRIGLGAMSMSAYYRA
MAV_2496|M.avium_104 -----------------------MKQAQLGGLQVGRLGLGAMGMSVAY--
MLBr_00458|M.leprae_Br4923 MRRFWRTVVEVTSQNSQALAQASGAFTLGGDLKVNRLGFGAMRLTGKG--
MMAR_2086|M.marinum_M ------------------MAAASATLTLGGDLTVNRLGFGAMRLTGDG--
Mvan_2555|M.vanbaalenii_PYR-1 --------------MTSGSSRTAPTFLLGGELPVNRLGFGAMRLTGPG--
Mflv_0942|M.gilvum_PYR-GCK -----------------MTTAIQTTLTLGGELPVPRMGYGAMQLAGPG--
Mb2320|M.bovis_AF2122/97 ----------------------MKYLDVDGIGQVSRIGLGTWQFGSRE--
Rv2298|M.tuberculosis_H37Rv ----------------------MKYLDVDGIGQVSRIGLGTWQFGSRE--
MUL_2745|M.ulcerans_Agy99 ----------------------MKHLEVDGIGNVSRIGLGTWQFGSRE--
MSMEG_4654|M.smegmatis_MC2_155 ------------------MTLDQYVTLGRSGLRVSPFALGAMTFGEDFG-
. * :. *: :
MAB_4120c|M.abscessus_ATCC_199 IGSESGPDEATSIDTLRRALDLGVSLIDTAEIYGPFVNEELVGRAIA---
MAV_2496|M.avium_104 --AGAGTDDAESIRTVHRAIELGVTLIDTAEVYGPYINEELLARALR---
MLBr_00458|M.leprae_Br4923 -VWGPPVDRYEAVRVLRRAVELGVNFIDTADSYGPYVSEEIIAEAL----
MMAR_2086|M.marinum_M -VWGPPADRAEAVRVLRRAAELGVNFIDTADSYGPYVSEEIIHEAL----
Mvan_2555|M.vanbaalenii_PYR-1 -VWGPPADRDECLRVLRRAVDLGVDFIDTADSYGPYISEDLIREAL----
Mflv_0942|M.gilvum_PYR-GCK -VLGLPDDVDNAVDVLRRAVDHGVRFFDTANAYGPRTVNQIIGRALG---
Mb2320|M.bovis_AF2122/97 WGYGDRYATGAARDIVKRARALGVTLFDTAEIYGLGKSERILGEALG---
Rv2298|M.tuberculosis_H37Rv WGYGDRYATGAARDIVKRARALGVTLFDTAEIYGLGKSERILGEALG---
MUL_2745|M.ulcerans_Agy99 WGYGDRYASGAARDIVARACALGVTLFDTAEVYGLGKSERILGEALG---
MSMEG_4654|M.smegmatis_MC2_155 ---AVGTSVENSERILSAYLDRGGNFIDTANFYTNGHSEKILGDFFARTP
. : * ::***: * : :: :
MAB_4120c|M.abscessus_ATCC_199 GRRDEVVLATKFGLVSHGNGASQVLDSTPGNISTAVEGSLRRLGVDHIDL
MAV_2496|M.avium_104 GRRDRVVLATKFGLISHTG--RDGLDSSPANIRVAVDGSLRRLATDHIDL
MLBr_00458|M.leprae_Br4923 HPYKGLVIATKAGLLRTGRDVWIPL-GNPSYLRQELEMSLRRLNVDTIDL
MMAR_2086|M.marinum_M HPYTGLVIATKAGLLRTGPGVWVPL-GNPSYLRQECEMSLRRLGVDTIDL
Mvan_2555|M.vanbaalenii_PYR-1 HPYDGVVIATKAGLLRTAPDVWEPL-GFPAYLRQECEMSLRRLGTDTIDL
Mflv_0942|M.gilvum_PYR-GCK TPADDLVIGNKVGAVRGPAGEWLQD-SRPEILRTQVEEALLDMRADASAL
Mb2320|M.bovis_AF2122/97 DDRTEVVVASKV----------FPVAPFPAVIKNRERASARRLQLNRIPL
Rv2298|M.tuberculosis_H37Rv DDRTEVVVASKV----------FPVAPFPAVIKNRERASARRLQLNRIPL
MUL_2745|M.ulcerans_Agy99 DERAEVVVASKI----------MPVAPFPAVVKQRERASARRLQLDRIPL
MSMEG_4654|M.smegmatis_MC2_155 GRRQHVVLASKFFGNMFPGDPNGGGAGRSSVLH-QLHDTLRRLQTDYLDV
:*:..* . : : : : :
MAB_4120c|M.abscessus_ATCC_199 YYQHRVDPN---------VAIEDTIGAVAELVQQGKVRYIGLSEAAAGTI
MAV_2496|M.avium_104 YYQHRLDRQ---------TPIEDTVGALAELVAAGKIRHIGLSEVGVNSI
MLBr_00458|M.leprae_Br4923 FQLHRIDPN---------FPLADQVGELFTLKNEGKIRHIGLSEINLDQL
MMAR_2086|M.marinum_M FQLHRIDRN---------YPLADQVGELLALKNEGKIRHIGLSEIDVDQL
Mvan_2555|M.vanbaalenii_PYR-1 FQLHRIAPK---------FPAEDQIGELAKLQQEGKVRHIGLSEVSVDQL
Mflv_0942|M.gilvum_PYR-GCK TYLRLAGDIRGVGEGPGEVPLEESLGALVELRDQGKIRHIGLSGASPAAL
Mb2320|M.bovis_AF2122/97 YQIHQPNPV---------VPDSVIMPGMRDLLDSGDIGAAGVSNYSLARW
Rv2298|M.tuberculosis_H37Rv YQIHQPNPV---------VPDSVIMPGMRDLLDSGDIGAAGVSNYSLARW
MUL_2745|M.ulcerans_Agy99 YQIHQPNPV---------VPDSVIMPGIRELLDIGRIGAAGVSNYSLARW
MSMEG_4654|M.smegmatis_MC2_155 YWLHNWDRN---------TPIEETMRTLDDLVRAGTVRYIGFSNTPAWVT
: . : : * * : *.*
MAB_4120c|M.abscessus_ATCC_199 RRAHAVH------PITALQNEYSLWTRDIEDEILPTIRELGIGLVAYSPL
MAV_2496|M.avium_104 RRAHAVH------PITAVQSEYSLWTRDQEDEILPVLRELGIGFVAYSPL
MLBr_00458|M.leprae_Br4923 TAAQQIT------EIVSVQNMYNLSARA-AEPLLDAVTSRGIGFIPWSPL
MMAR_2086|M.marinum_M EAAQQIT------EIVSVQNMYNLAARG-AEPLLEAATSQGIAFIPWFPL
Mvan_2555|M.vanbaalenii_PYR-1 TAARAVA------PIVSVQNMYNLTMRA-AEPVLDACEADGIAFIPWFPL
Mflv_0942|M.gilvum_PYR-GCK ERAQQIT------TIAAVQNRFNLIDRS-GVEVLAACERDGIAFVPYFPL
Mb2320|M.bovis_AF2122/97 RKADAALGR----PVVSNQVHFSLAHPDALEDLVPFAELENRIVIAYSPL
Rv2298|M.tuberculosis_H37Rv RKADAALGR----PVVSNQVHFSLAHPDALEDLVPFAELENRIVIAYSPL
MUL_2745|M.ulcerans_Agy99 KKADAALGR----PVVSNQVHFSLAHPGPLDDLVPFAERENRIIIAYSPL
MSMEG_4654|M.smegmatis_MC2_155 AQAQTMAMLRGWTPLIALQVEYSLLARTVESEVAPFAQDQGIALVPWSPL
* : : * :.* : . .:.: **
MAB_4120c|M.abscessus_ATCC_199 GRGFLTGAIGSRDQLAEGDFRREQPRFSAENFDANLALVEEVRSVASSIG
MAV_2496|M.avium_104 GRGFLTGAIRSAHELPDTDYRRTNPRFAEQNFAHNLRCADELRDIAADVG
MLBr_00458|M.leprae_Br4923 AAGPLAAP--------DGPLQR----------------------IAVNHH
MMAR_2086|M.marinum_M ASGPLAAP--------DGPLRK----------------------IADDHH
Mvan_2555|M.vanbaalenii_PYR-1 AAGPLAAA--------DGPLHR----------------------IAAEHH
Mflv_0942|M.gilvum_PYR-GCK ATGGLGD---------DDELRR----------------------PGERLG
Mb2320|M.bovis_AF2122/97 AQGLLGGKYG--LENRPGGVRALNPLFGTENLRRIEPLLATLRAIAVDVD
Rv2298|M.tuberculosis_H37Rv AQGLLGGKYG--LENRPGGVRALNPLFGTENLRRIEPLLATLRAIAVDVD
MUL_2745|M.ulcerans_Agy99 AQGLLGGKYG--VDNRPAGVRAVNPLFGTENLRRIEPLLQTLRAVAIDVD
MSMEG_4654|M.smegmatis_MC2_155 KNGFLSGKYR---RDSAAVDSARAAFVGGGPSESDFDVIEAVAGIADELE
* * .
MAB_4120c|M.abscessus_ATCC_199 ATSAQVALAWLLARGDDIVPIPGTTKVSRVNENVGAVDIE--LLPEHLVR
MAV_2496|M.avium_104 ATPAQVALAWLLAKGPDIVPIPGTKRVARLEENVGADALE--LTTEQLSR
MLBr_00458|M.leprae_Br4923 ATPSQLALAWLLKRSPVMLPIPGTSRVAHLEENVAAAEIS--LSDDEFEM
MMAR_2086|M.marinum_M ATPSQLALAWLLKRSPVMLPIPGTSRVAHLQENVAAAEIV--LSDQEFEA
Mvan_2555|M.vanbaalenii_PYR-1 ATPSQLALAWLLKRSPVMLPIPGTSKVAHLEENVAAAQID--LTDAEFET
Mflv_0942|M.gilvum_PYR-GCK VPMSTIALAWLLRRSPVIVPIPGTKSVAHLRDNLSAAQVADQLTEDEVHA
Mb2320|M.bovis_AF2122/97 AKPAQVALAWLIS-LPGVVAIPGASSVEQLEFNVAAADIE--LSAQSRDA
Rv2298|M.tuberculosis_H37Rv AKPAQVALAWLIS-LPGVVAIPGASSVEQLEFNVAAADIE--LSAQSRDA
MUL_2745|M.ulcerans_Agy99 AKPAQVALAWLIS-LPGVVAIPGASSVEQLEFNVAAADIE--LSADARAA
MSMEG_4654|M.smegmatis_MC2_155 TSSAAVALAWLRARPGTVVPIIGARRMEHLESNVEALGVE--LTSEQLKL
. : :***** ::.* *: : ::. *: * : *
MAB_4120c|M.abscessus_ATCC_199 LECLAAAAGDRYNAEHLARLEG--------------------------
MAV_2496|M.avium_104 LDRLTPPVGGHHADAQLAWIDR--------------------------
MLBr_00458|M.leprae_Br4923 LSAAGAQ-----------------------------------------
MMAR_2086|M.marinum_M LSVAGAAHGG--------------------------------------
Mvan_2555|M.vanbaalenii_PYR-1 LGNAGAAAS---------------------------------------
Mflv_0942|M.gilvum_PYR-GCK LTAVEDEQSATLSTMPSRMTDAFARVVSPPGSGRRR------------
Mb2320|M.bovis_AF2122/97 LTDAARAFRPVSTGRFLTDMVREKVSRR--------------------
Rv2298|M.tuberculosis_H37Rv LTDAARAFRPVSTGRFLTDMVREKVSRR--------------------
MUL_2745|M.ulcerans_Agy99 LTEAARAFHPVSARRFLTDTVREKLGRR--------------------
MSMEG_4654|M.smegmatis_MC2_155 LDEVSAPVLSYPAEVNGEVRASLQFAGTTVDGETSTVFPALLAGDARY
*