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RGALMLKYRESNLVKAGLIGTVLMILVVAVGLQPERLLQWATSVRHQALFTEAGGIAVGNDVTLSGIKVG SVTDIRLQNGDALVTFTTEGRYPLGSTTTAHIRTGSLLGERVLTLEPAGSGTLRSTDVIPTSRTSSPYSL TDAVGELAENTKGALRT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4792 | - | - | 100% (158) | virulence factor mce family protein |
| M. smegmatis MC2 155 | MSMEG_2857 | - | 2e-46 | 58.50% (147) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_5898 | - | 5e-23 | 37.67% (146) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3527c | mce4C | 3e-23 | 39.01% (141) | MCE-family protein MCE4C |
| M. gilvum PYR-GCK | Mflv_2510 | - | 2e-58 | 72.97% (148) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv3497c | mce4C | 3e-23 | 39.01% (141) | MCE-family protein MCE4C |
| M. leprae Br4923 | MLBr_02591 | mce1C | 3e-15 | 28.87% (142) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_4151c | - | 5e-20 | 33.56% (149) | MCE-family protein |
| M. marinum M | MMAR_4708 | - | 4e-50 | 65.10% (149) | MCE-family protein |
| M. avium 104 | MAV_0950 | - | 5e-52 | 64.05% (153) | virulence factor Mce family protein |
| M. thermoresistible (build 8) | TH_4269 | - | 1e-59 | 72.48% (149) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_4060 | mce4C | 3e-21 | 38.81% (134) | MCE-family protein Mce4C |
| M. vanbaalenii PYR-1 | Mvan_4148 | - | 4e-57 | 72.97% (148) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3527c|M.bovis_AF2122/97 MLNRKPSSKHERDPLRTGIFGLVLVICVVLIAFGYSGLPFWPQGKTYDAY
Rv3497c|M.tuberculosis_H37Rv MLNRKPSSKHERDPLRTGIFGLVLVICVVLIAFGYSGLPFWPQGKTYDAY
MUL_4060|M.ulcerans_Agy99 ----MPSSKHDRDSLRTGIFGVVLVICVVLIAFGYSGLPFLPQGKTYNAY
MAB_4151c|M.abscessus_ATCC_199 -MPSKMSDIQEKDPVRTGIFGIAVVSMLVLVAFGYTGLPFWPQGKQYTGY
MSMEG_4792|M.smegmatis_MC2_155 MRGALMLKYRESNLVKAGLIGTVLMILVVAVGLQPERLLQWATSVRHQAL
TH_4269|M.thermoresistible__bu -----MRKYRETNLMRAGFIGFVLIVLVITIGLQPERIIQWATSIRYQAL
Mflv_2510|M.gilvum_PYR-GCK -----MLKYRGSQLIRAGFIGVILIILVIAVGLQPERLLSWATAIRYQAL
Mvan_4148|M.vanbaalenii_PYR-1 -----MLKYRGSQLARAGFIGVVLIILVIAVGLQPERLLSWATAIRYQAL
MMAR_4708|M.marinum_M -----MLKYRGAGLIRAGFIGAVLIVLVIAVGLNPEQLLQRATTVRYQAL
MAV_0950|M.avium_104 -----MLKYRGSGLVKAGLIGVVLAVMVILVGLSPDRFIAWATMVRYQAL
MLBr_02591|M.leprae_Br4923 -----MRTLELPNRLRSGLIGVLVVLLIIGVGQSFTSVPILFARPSYYGQ
. ::*::* : :: :. . : .
Mb3527c|M.bovis_AF2122/97 FTDAGGITPGNSVYVSGLKVGAVSAVSLAGNSAKVTFSVDRSIVVGDQSL
Rv3497c|M.tuberculosis_H37Rv FTDAGGITPGNSVYVSGLKVGAVSAVSLAGNSAKVTFSVDRSIVVGDQSL
MUL_4060|M.ulcerans_Agy99 FSDAGGITPGNNVYVSGFKVGTVSDVSLAGDAAKITFSVDRHVVVGDQSL
MAB_4151c|M.abscessus_ATCC_199 FADSGGLESGGNVFVSGIKVGQVKDVSLAGNKVRVDFTVDRSIRLGDQSL
MSMEG_4792|M.smegmatis_MC2_155 FTEAGGIAVGNDVTLSGIKVGSVTDIRLQNGDALVTFTTEGRYPLGSTTT
TH_4269|M.thermoresistible__bu FSEAGGITVGNDVTISGIKVGTVNEVTLHDGDALVTFTVAGKHQLGAQTT
Mflv_2510|M.gilvum_PYR-GCK FTEAGGLTVGNDVTVSGIKVGSVSSIKLDNGDALVGFTIDGKYALGSDTT
Mvan_4148|M.vanbaalenii_PYR-1 FAEAGGLTVGNDVTVSGIKVGSVSSIELDNGDALVGFTIDGKYALGSDTT
MMAR_4708|M.marinum_M FSDAGGLAVGNDVTVSGIKVGTVSGMSLQRGDVLVTFTVNGGVELGADST
MAV_0950|M.avium_104 FTEAGGLATGNPVVVSGMKVGTVSDVKLHRGDALVTFALKGNILLGSETT
MLBr_02591|M.leprae_Br4923 FTDTGGLNKGDKVRIAGMDVGKVEALKIDGDHVVIKFSIG-TNRIGTASR
*:::**: *. * ::*:.** * : : . . : *: :* :
Mb3527c|M.bovis_AF2122/97 AAIRTDTILGERSIAVSPAGSGKS---TTIPLSRTTTPYTLNGVLQDLGR
Rv3497c|M.tuberculosis_H37Rv AAIRTDTILGERSIAVSPAGSGKS---TTIPLSRTTTPYTLNGVLQDLGR
MUL_4060|M.ulcerans_Agy99 AAIRTDTILGERSVAVTPAGSGNA---TTIPLSRTTTPYTLNGALKDLGG
MAB_4151c|M.abscessus_ATCC_199 AAIRTTTVLGEKSLSVTPAGAGRI---TEIPLGRTTTPYTLNSALSDLGA
MSMEG_4792|M.smegmatis_MC2_155 AHIRTGSLLGERVLTLEPAGSGTLRSTDVIPTSRTSSPYSLTDAVGELAE
TH_4269|M.thermoresistible__bu AHIRTGSLLGERVITLESYGSEPLRGTDVIPTSRTSSPYSLTDAVGDLAT
Mflv_2510|M.gilvum_PYR-GCK AHIRTGTLLGERVLALDSEGSGTLDPQQVIPTTRTSSPYSLTDAVSELTS
Mvan_4148|M.vanbaalenii_PYR-1 AHIRTGTLLGERVLALDSDGSGTLDPQQVIPTTRTSSPYSLTDAVSELTA
MMAR_4708|M.marinum_M AHIRTGSLLGQRVLTVESAGGHTLRPMAVIPVSRTSSPYSLSEAVSDAAT
MAV_0950|M.avium_104 AHIRTGTLLGERMLTLESAGTGTMHPMALIPVSRTSSPYSLTEAVSDLTT
MLBr_02591|M.leprae_Br4923 LGIRTDTVLGKKVLEVETRGTQLLRPGDSLPLGQSTTPYQSYDAFFDATK
*** ::**:: : : . * :* ::::** .. :
Mb3527c|M.bovis_AF2122/97 NANDLNRPQFEQALNVFTQALHDATPQVRGAVDGLTSLSRALNRRDEALQ
Rv3497c|M.tuberculosis_H37Rv NANDLNRPQFEQALNVFTQALHDATPQVRGAVDGLTSLSRALNRRDEALQ
MUL_4060|M.ulcerans_Agy99 SASNLDKPQFEHALQVLTETLHDATPQLRGALDGVTALSRTLNTRDEALQ
MAB_4151c|M.abscessus_ATCC_199 SAGGIDKAQLDQSLQVITEAMRDATPQLRGALDGVASLSRTLNARDAALE
MSMEG_4792|M.smegmatis_MC2_155 NTKG--------ALRT----------------------------------
TH_4269|M.thermoresistible__bu NTAGTDTAALNQALDTLSATIDQIAPRLGPTFDGLSRLSRSLNDRNENLA
Mflv_2510|M.gilvum_PYR-GCK NTRDTDTEALNQSLDTLSQTLDQIAPQLGPTFDGLSRLSQSLNSRNDSLA
Mvan_4148|M.vanbaalenii_PYR-1 NTRDTDTASLNQSLDTLAQTLDQVAPQLGPTFDGLSRLSQSLNSRNESLA
MMAR_4708|M.marinum_M DIAGTNTDALNQSLDTLSETLNQIAPQLGPSFDGLTRLSQALNGRNQTLG
MAV_0950|M.avium_104 DTAGTNTTALNQSLDTLAATLDQIAPQMGPAFDALTRLSRTLNSRNKNLG
MLBr_02591|M.leprae_Br4923 VASGWNIDTIKQSLKVVSETIDQTYPHLSAALDGVAKFSDTIGARDKEIK
. :* .
Mb3527c|M.bovis_AF2122/97 GLLAHAKSVTSVLSERAEQVNKLVEDGNQLFAALDARRAALSALISGIDD
Rv3497c|M.tuberculosis_H37Rv GLLAHAKSVTSVLSERAEQVNKLVEDGNQLFAALDARRAALSALISGIDD
MUL_4060|M.ulcerans_Agy99 GLLAHAKTVTGVLSERAAQVDKLIQDGNQLFAALDERRSALGALISGIDD
MAB_4151c|M.abscessus_ATCC_199 QLLTHAKSVSGILSERAGQVNKLVTDGNQLFAALDERRLAISELINRIQG
MSMEG_4792|M.smegmatis_MC2_155 --------------------------------------------------
TH_4269|M.thermoresistible__bu GLLASAGEVTKVLAERSQQLNTLILNANDLLAVLNERREAIVTLLANTSA
Mflv_2510|M.gilvum_PYR-GCK ELLRTAGEVTGIFSERSKQVNTLILNSNDLLAVLNERRYAITSLLSNISA
Mvan_4148|M.vanbaalenii_PYR-1 ELLRTAGDVTGIFSERSSQVNALILNANDLLAVLNERRYAITSLLANISA
MMAR_4708|M.marinum_M ELLKGAADVTGILSQRSQQLNTLILNADDLLSMLVARRQAIVRLLASTSA
MAV_0950|M.avium_104 ELFKSAGDVTGVLSERSQQVNKLILNSDVLLQVLVARRQEIVDLLANTSA
MLBr_02591|M.leprae_Br4923 HLIAQANQVASVLGDRGAQVDRLLVNTKTLIAAFNERGRAVDALLGNVAA
Mb3527c|M.bovis_AF2122/97 VAAQISGFVADNRKEFGPALSKLNLVLANLNERRDYITEALKRLPTYATT
Rv3497c|M.tuberculosis_H37Rv VAAQISGFVADNRKEFGPALSKLNLVLANLNERRDYITEALKRLPTYATT
MUL_4060|M.ulcerans_Agy99 VSVQLSGFVNDNRKEFGRALSKLNLVVSNLNERRDYITEALKRLPAYATT
MAB_4151c|M.abscessus_ATCC_199 LSQQISGFVADNRQEFRPTMEKLSVVLDDLLDRKAHISEALKRLPGYGTA
MSMEG_4792|M.smegmatis_MC2_155 --------------------------------------------------
TH_4269|M.thermoresistible__bu VAQELTALVADNEAELAPTLERLNSVMEMLERNRDNIAKILPNLKKFILA
Mflv_2510|M.gilvum_PYR-GCK VSQQLSGLVADNEAELAPALERLNNVTRMLEKNRDNLARMLPGAAKYYLT
Mvan_4148|M.vanbaalenii_PYR-1 VSQQLSGVVADNEAELAPALERLNNVTQMLEKNRDNLAKMLPGAAKYYLT
MMAR_4708|M.marinum_M VAKQLSGLVHDNESKLAPTLERLNAVTAMLEKNRDNLAKALPGLAKYELT
MAV_0950|M.avium_104 VAKQLTALVHDNESKLAPTLERLNSVTAMLEKNRDNISKALPGLKKFEIT
MLBr_02591|M.leprae_Br4923 FAAQVQRLINDN-PNLNHVLEQLHQLSGILVQHKDDLANTLIQVAAFLPS
Mb3527c|M.bovis_AF2122/97 LGEVVGSGPGFNVNVYSVLPGPLVATVFDLVFQPG---------------
Rv3497c|M.tuberculosis_H37Rv LGEVVGSGPGFNVNVYSVLPGPLVATVFDLVFQPG---------------
MUL_4060|M.ulcerans_Agy99 LGEVVGSGPGFNVNVYSVLPAPMVAMVFDTVFQPG---------------
MAB_4151c|M.abscessus_ATCC_199 LGEVVSSGPGFHVNVYGFPPATLTAVAFDTYFQPG---------------
MSMEG_4792|M.smegmatis_MC2_155 --------------------------------------------------
TH_4269|M.thermoresistible__bu QGETLANGPYYNAFVPNLNPAQILQPFLDYAFGFR---------------
Mflv_2510|M.gilvum_PYR-GCK QGEIVSNGAYYNALVPNVQPAQLLQPFLEYAFGFR---------------
Mvan_4148|M.vanbaalenii_PYR-1 QGEIVSNGAYYNALIPNIQPAQLLQPFLDYAFGFR---------------
MMAR_4708|M.marinum_M QGETVSSGFYYNPFIPNLFTIQFFQWFIDYAFGFR---------------
MAV_0950|M.avium_104 VGEAISSMYAYSAFVPNFLAPQLFQPFLDYLWGFR---------------
MLBr_02591|M.leprae_Br4923 LNEAIGSGPFFKVVLHNLAPYQILQPWVDAAFKKRGIDPENFWRSAGLPE
Mb3527c|M.bovis_AF2122/97 ----------------------------------------KLPDSLADYL
Rv3497c|M.tuberculosis_H37Rv ----------------------------------------KLPDSLADYL
MUL_4060|M.ulcerans_Agy99 ----------------------------------------KLPDSFADYL
MAB_4151c|M.abscessus_ATCC_199 ----------------------------------------KLPASLSDYL
MSMEG_4792|M.smegmatis_MC2_155 --------------------------------------------------
TH_4269|M.thermoresistible__bu ----------------------------------------RGT-NAGQPP
Mflv_2510|M.gilvum_PYR-GCK ----------------------------------------NGV-DIGQPP
Mvan_4148|M.vanbaalenii_PYR-1 ----------------------------------------NGV-DIGQPP
MMAR_4708|M.marinum_M ----------------------------------------AHG-APGQPP
MAV_0950|M.avium_104 ----------------------------------------TFDTARGPGH
MLBr_02591|M.leprae_Br4923 FRFPDPNGTRFPNGAPPPAPPVLEGTPENPGPAVPPGSPCSYTPAHPGGN
Mb3527c|M.bovis_AF2122/97 RGFIQERWIIRPKSP-----------------------------------
Rv3497c|M.tuberculosis_H37Rv RGFIQERWIIRPKSP-----------------------------------
MUL_4060|M.ulcerans_Agy99 RGLIQERWTIRPKSS-----------------------------------
MAB_4151c|M.abscessus_ATCC_199 NGLIGERQIMRPKSP-----------------------------------
MSMEG_4792|M.smegmatis_MC2_155 --------------------------------------------------
TH_4269|M.thermoresistible__bu DTVGPRAELPLPYNAIPGGTR-----------------------------
Mflv_2510|M.gilvum_PYR-GCK DNAGPRAQLPFPVNSLPQPGDLPNDGNP----------------------
Mvan_4148|M.vanbaalenii_PYR-1 DNAGPRAQLPFPVNSLPQPGDLPNDGNP----------------------
MMAR_4708|M.marinum_M DNAGPRALFPFPFNQNP-----------GGSR------------------
MAV_0950|M.avium_104 PSPVPRSLIPWPYNGIPVCPGCTLGGRVGGSQ------------------
MLBr_02591|M.leprae_Br4923 NTIGDEMGLPRPWNPLPCAGATAGPYGGPAFPAPIDVQTSPPNPDGLPLL
Mb3527c|M.bovis_AF2122/97 --------------------------------------------------
Rv3497c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_4060|M.ulcerans_Agy99 --------------------------------------------------
MAB_4151c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_4792|M.smegmatis_MC2_155 --------------------------------------------------
TH_4269|M.thermoresistible__bu --------------------------------------------------
Mflv_2510|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4148|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_4708|M.marinum_M --------------------------------------------------
MAV_0950|M.avium_104 --------------------------------------------------
MLBr_02591|M.leprae_Br4923 PGIAIAGRPGDPAPNVPGTPVPLPPNAPPGARTEQLAPAAPAQDSSAPHE
Mb3527c|M.bovis_AF2122/97 --------------------------
Rv3497c|M.tuberculosis_H37Rv --------------------------
MUL_4060|M.ulcerans_Agy99 --------------------------
MAB_4151c|M.abscessus_ATCC_199 --------------------------
MSMEG_4792|M.smegmatis_MC2_155 --------------------------
TH_4269|M.thermoresistible__bu --------------------------
Mflv_2510|M.gilvum_PYR-GCK --------------------------
Mvan_4148|M.vanbaalenii_PYR-1 --------------------------
MMAR_4708|M.marinum_M --------------------------
MAV_0950|M.avium_104 --------------------------
MLBr_02591|M.leprae_Br4923 PREQLSAPLINPGGTGGSGGAGGSRN