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AVVVAIGAGVTVTVISGGSGKNTSTAESQPSAPPVPVGALRGLLLTPAEAAKAVGTNTLSGSEEMGDKIY DKAGAGSIVDGDCVSLMPGTEAKYTGSGYTAVRRQYLVNRPEIDYLTQVVIAFPSAELAEKFITSSEEAW RKCSGRTVNVRYTSPDTPPGPPAFEVIGPVSSNDGMITLRRTREGTGDADGDWGCSIASTARNNIVIEGE VCSRTKDSAVTELVRATADKVTAHK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4598 | lppH | - | 100% (236) | putative lipoprotein lpph |
| M. smegmatis MC2 155 | MSMEG_4595 | - | 4e-14 | 28.84% (267) | serine/threonine-protein kinase PknH, putative |
| M. smegmatis MC2 155 | MSMEG_4597 | lppH | 1e-12 | 28.37% (215) | putative lipoprotein lpph |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3607 | lppH | 1e-18 | 32.14% (196) | lipoprotein LppH |
| M. gilvum PYR-GCK | Mflv_2235 | - | 3e-09 | 25.63% (238) | putative lipoprotein LppH |
| M. tuberculosis H37Rv | Rv3576 | lppH | 1e-18 | 32.14% (196) | lipoprotein LppH |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0361 | - | 2e-07 | 30.00% (120) | hypothetical protein MAB_0361 |
| M. marinum M | MMAR_5074 | lppH | 7e-16 | 29.49% (234) | lipoprotein LppH |
| M. avium 104 | MAV_1417 | - | 1e-15 | 29.67% (246) | serine/threonine-protein kinase PknE |
| M. thermoresistible (build 8) | TH_3756 | - | 1e-11 | 27.11% (225) | PUTATIVE putative conserved lipoprotein LppH |
| M. ulcerans Agy99 | MUL_4150 | lppH | 2e-16 | 29.49% (234) | lipoprotein LppH |
| M. vanbaalenii PYR-1 | Mvan_4738 | - | 6e-15 | 31.38% (239) | putative lipoprotein LppH |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2235|M.gilvum_PYR-GCK --------------------------------------------------
TH_3756|M.thermoresistible__bu --------------------------------------------------
Mvan_4738|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb3607|M.bovis_AF2122/97 --------------------------------------------------
Rv3576|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_5074|M.marinum_M --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
MAV_1417|M.avium_104 MSDERSSKVGSMFGPYHLKRLLGRGGMGEVYEAEHTVKEWTVAVKLLNES
MSMEG_4598|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0361|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_2235|M.gilvum_PYR-GCK --------------------------------------------------
TH_3756|M.thermoresistible__bu --------------------------------------------------
Mvan_4738|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb3607|M.bovis_AF2122/97 --------------------------------------------------
Rv3576|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_5074|M.marinum_M --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
MAV_1417|M.avium_104 FSSDPVFRERMKREARTAGRLQEPHVVPVHDYGEIDGQMFLEMRLVEGTD
MSMEG_4598|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0361|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_2235|M.gilvum_PYR-GCK --------------------------------------------------
TH_3756|M.thermoresistible__bu --------------------------------------------------
Mvan_4738|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb3607|M.bovis_AF2122/97 --------------------------------------------------
Rv3576|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_5074|M.marinum_M --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
MAV_1417|M.avium_104 LDSVLKRFGPLPPPRAVAIITQIASALDAAHAAGVMHRDVKPQNILVTRD
MSMEG_4598|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0361|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_2235|M.gilvum_PYR-GCK --------------------------------------------------
TH_3756|M.thermoresistible__bu --------------------------------------------------
Mvan_4738|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb3607|M.bovis_AF2122/97 --------------------------------------------------
Rv3576|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_5074|M.marinum_M --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
MAV_1417|M.avium_104 DFAYLVDFGIASATTDEKLTQLGTAVGTWKYMAPERFSDAEVTYRADIYA
MSMEG_4598|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0361|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_2235|M.gilvum_PYR-GCK --------------------------------------------------
TH_3756|M.thermoresistible__bu --------------------------------------------------
Mvan_4738|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb3607|M.bovis_AF2122/97 --------------------------------------------------
Rv3576|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_5074|M.marinum_M --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
MAV_1417|M.avium_104 LACVLFECLTGSAPYRADSAGVLVSAHVMDPIPAPSARRPGVPKAFDAVI
MSMEG_4598|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0361|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_2235|M.gilvum_PYR-GCK ----------------------------------MRRAVAIAGIAIMVTG
TH_3756|M.thermoresistible__bu -------------------------------------------MGVLVAG
Mvan_4738|M.vanbaalenii_PYR-1 -------------------------------MREHTAALTVAATCVLVAA
Mb3607|M.bovis_AF2122/97 -----------------------------MGKQLAALAALVG-ACMLAAG
Rv3576|M.tuberculosis_H37Rv -----------------------------MGKQLAALAALVG-ACMLAAG
MMAR_5074|M.marinum_M -----------------------------MRQRVAALAALVGGAGMLVTG
MUL_4150|M.ulcerans_Agy99 -----------------------------MRQRVAALAALVGGAGMLVTG
MAV_1417|M.avium_104 ARGMAKKPEDRYASAGDLALAAKEALSTPDQDRAATILRRSQEAALPAAG
MSMEG_4598|M.smegmatis_MC2_155 --------------------------------MAVVVAIGAGVTVTVISG
MAB_0361|M.abscessus_ATCC_1997 ----------------------------------MTIVLSAALACAAPAL
:
Mflv_2235|M.gilvum_PYR-GCK CASTS-------------SAESAEPP--TRTMIPR---------------
TH_3756|M.thermoresistible__bu CGSTG-------------HAESTTAPSTTKTLIPR---------------
Mvan_4738|M.vanbaalenii_PYR-1 CGGGGNEGATSTTPSTLLSPTTSAPAPPTTSTPPP---------------
Mb3607|M.bovis_AF2122/97 CTNVVDG--------------TAVAADKSGPLHQD---------------
Rv3576|M.tuberculosis_H37Rv CTNVVDG--------------TAVAADKSGPLHQD---------------
MMAR_5074|M.marinum_M CTNIVDG--------------NAVAADMSGPLNQT---------------
MUL_4150|M.ulcerans_Agy99 CTNIVDG--------------NAVAADMSGPLNQT---------------
MAV_1417|M.avium_104 QRDAGASTVLAPPPAVNTRQPGSAASQAGRGWTPESGPIPAAGQPGPPYY
MSMEG_4598|M.smegmatis_MC2_155 GSGKN------------------TSTAESQPSAPP---------------
MAB_0361|M.abscessus_ATCC_1997 AEQGS---------------------------------------------
Mflv_2235|M.gilvum_PYR-GCK --------------------------------------------------
TH_3756|M.thermoresistible__bu --------------------------------------------------
Mvan_4738|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb3607|M.bovis_AF2122/97 --------------------------------------------------
Rv3576|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_5074|M.marinum_M --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
MAV_1417|M.avium_104 QGGNANWAAAPAQFAGPPPWGRPPPKRRVWPIVAAVVAVLVVIAGGVGVW
MSMEG_4598|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0361|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_2235|M.gilvum_PYR-GCK -------------PLVEREIGEVLLSPEEIAALMGVPAMT-VIEAQTSLS
TH_3756|M.thermoresistible__bu -------------PLVERELPGLLLSPEQVNAAMGTTDMA-IISSQTSLS
Mvan_4738|M.vanbaalenii_PYR-1 -------------PVAESALDGLLLSPAEIDTVVGATGMA-VAGTSTSLA
Mb3607|M.bovis_AF2122/97 -------------PIPVSALEGLLLDLSQINAALGATSMK-VWFNAKAMW
Rv3576|M.tuberculosis_H37Rv -------------PIPVSALEGLLLDLSQINAALGATSMK-VWFNAKAMW
MMAR_5074|M.marinum_M -------------PIAVSALDDLLLDVNQIDSALGATSMK-VWFNAKAMW
MUL_4150|M.ulcerans_Agy99 -------------PIAVSALDDLLLDVSQIDSALGATSMK-VWFNAKAMW
MAV_1417|M.avium_104 LVIRPKPEPPQAAPLTSDRLGALLLSASEVNAVMGSSTME-PGKPITATD
MSMEG_4598|M.smegmatis_MC2_155 --------------VPVGALRGLLLTPAEAAKAVGTNTLSGSEEMGDKIY
MAB_0361|M.abscessus_ATCC_1997 -------------PIPPAAIDDLMVTPDEASSVMKTGFPVVDRFNALSAL
: : ::: : :
Mflv_2235|M.gilvum_PYR-GCK DHSDI--MAPIE---CLAIDGAGELQVYANSDYRASRDQSLN----DGEG
TH_3756|M.thermoresistible__bu DHSNT--MAPPE---CLALDGAGEADVYADSGYRAARDHSLN----NGDN
Mvan_4738|M.vanbaalenii_PYR-1 EDITVPPDAPEEKKACVGIAGTAEAQAYAGSGSTAVRDQALRA--PNDSG
Mb3607|M.bovis_AF2122/97 DWSKS--VADKN---CLAIDGPAQEKVYAGTGWTAMRGQRLDDSINDSKK
Rv3576|M.tuberculosis_H37Rv DWSKS--VADKN---CLAIDGPAQEKVYAGTGWTAMRGQRLDDSIDDSKK
MMAR_5074|M.marinum_M DWSKN--ISDKN---CLAVDGPAQDEVYAGTGWTAMRGQRMDDSVDDSKR
MUL_4150|M.ulcerans_Agy99 DWSKN--ISDKN---CLAVDGPAQDEVYAGTGWTAMRGQRMDDSVDDSKR
MAV_1417|M.avium_104 SSSVTVSVPD-----CQGALYTTQDPVYAGSGYSAVNGLVSSE---PGDN
MSMEG_4598|M.smegmatis_MC2_155 DKAGAGSIVDGD---CVSLM-PGTEAKYTGSGYTAVRRQYLVN-----RP
MAB_0361|M.abscessus_ATCC_1997 TTDRP----------DCGSVVLPSVATYDRGPYMAAHQQYLQD----SAP
. * * .
Mflv_2235|M.gilvum_PYR-GCK WKTYVKQAVVLFPYLEKAGEFFDASVAQWPACR-----EYTHTQSGSV--
TH_3756|M.thermoresistible__bu FTHYAKQAVVLFPLAETARAFFEASAEQWPACH-----EYRHTQSGTK--
Mvan_4738|M.vanbaalenii_PYR-1 ATLSAGQAVVLFPTADEAATFFAESAQKWPLCR-----GYN--AGGSP--
Mb3607|M.bovis_AF2122/97 RDHYAIQAVVGFPTAHDAEEFYSSSVQSWSSCSNRRFVEVTPGQDDAA--
Rv3576|M.tuberculosis_H37Rv RDHYAIQAVVGFPTAHDAEEFYSSSVQSWSSCSNRRFVEVTPGQDDAA--
MMAR_5074|M.marinum_M RKHYAIQAVVAFPSAHDASAFYNSSVRSWGNCSNRRFTDVSTDQPDTI--
MUL_4150|M.ulcerans_Agy99 RKHYAIQAVVAFPSAHDASAFYNSSVRSWGNCSNRRFTDVSTDQPDTI--
MAV_1417|M.avium_104 YDHWVNQAVVLFPSADKAKSFLQTSLQKWKGCAG-QTVTVTNKSKTYR--
MSMEG_4598|M.smegmatis_MC2_155 EIDYLTQVVIAFPSAELAEKFITSSEEAWRKCSG-RTVNVRYTSPDTPPG
MAB_0361|M.abscessus_ATCC_1997 WNVQLAQSIAVFPTDDEARDFASTEMDMWLKCSK----HTVHDSAQWR--
* : ** . * * . * *
Mflv_2235|M.gilvum_PYR-GCK ----WNPGEITSADRTLSTVAMQR--DAAAPGWGCGRALVHRNNVIVDVN
TH_3756|M.thermoresistible__bu ----WYVAELTRDGDILKAITVQR--DAGHPGWGCGRALVLRNNIIGDVN
Mvan_4738|M.vanbaalenii_PYR-1 ----VTVGDVSSDNGMLVTSITIQ--SEDEPTL-CERALTMKNNIVIDVS
Mb3607|M.bovis_AF2122/97 ----WTVADVVNDNGMLSSSQVQE--GGD--GWTCQRALTARNNVTIDIV
Rv3576|M.tuberculosis_H37Rv ----WTVADVVNDNGMLSSSQVQE--GGD--GWTCQRALTARNNVTIDIV
MMAR_5074|M.marinum_M ----WTVSDVVNDNGMLSTSQVQE--AGD--GWTCQRALTVRNNVAIDVV
MUL_4150|M.ulcerans_Agy99 ----WTVSDVVNDNGMLSTSQVQE--AGD--GWTCQRALTVRNNVAIDVV
MAV_1417|M.avium_104 ----WTFAQVQGAPPKITLMDTQE--GAD--GWECQRALSVANNVIVDIN
MSMEG_4598|M.smegmatis_MC2_155 PPAFEVIGPVSSNDGMITLRRTREGTGDADGDWGCSIASTARNNIVIEGE
MAB_0361|M.abscessus_ATCC_1997 ----YAIGSLHRDDDAVVGSYVMI--TNDGARMSCSRLLARVRNTATDLR
. : : * .* :
Mflv_2235|M.gilvum_PYR-GCK TCS--AAPGDSAVRIAHQIADKVDAQW
TH_3756|M.thermoresistible__bu TCS--ADPGDSAVRIAQQIGENVDAVW
Mvan_4738|M.vanbaalenii_PYR-1 TCG--GSS-DSAVRIADQIAARVPGE-
Mb3607|M.bovis_AF2122/97 TCAY-SQPDLVAIGIANQIAAKVAKQ-
Rv3576|M.tuberculosis_H37Rv TCAY-SQPDLVAIGIANQIAAKVAKQ-
MMAR_5074|M.marinum_M TCAY-SQSGSVAADVAQQIAAKAAKQ-
MUL_4150|M.ulcerans_Agy99 TCAY-SQSGSVAADVAQQIAAKAAKQ-
MAV_1417|M.avium_104 ACG--YRITDQGDQIADKIVAKIDNE-
MSMEG_4598|M.smegmatis_MC2_155 VCS--RTKDSAVTELVRATADKVTAHK
MAB_0361|M.abscessus_ATCC_1997 ACSAGPESYQRLLGIAKIIGPRYDAA-
.*. :. .