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LLPSPPNKGRKKKWVLGVAAVAAAVGVAGVGVVNLRSDDRSESEPLAHPTSTTPAPPRVDSGLPVTALPN LLLTPAEMNAALGTSRFEAPPPTNQLNQNASSHPQCGAVVEVGLRSAYEGSGYRAVQFQYGQNEEPSGDP LADAFGSPLVRVGQMVTAFPDATAASKFVADQSGKWRQCTHTGAVSLIVEGQPNTDFHVSEVPQNDKHTV QGVLTMELYYAGPQRGNWNCYHSLGAQRNIVADVMVCDGQVKHYQSAKIVERILAKVPAT
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4595 | - | - | 100% (270) | serine/threonine-protein kinase PknH, putative |
| M. smegmatis MC2 155 | MSMEG_4598 | lppH | 5e-14 | 28.84% (267) | putative lipoprotein lpph |
| M. smegmatis MC2 155 | MSMEG_4596 | - | 3e-11 | 25.24% (206) | hypothetical protein MSMEG_4596 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2115 | pknJ | 2e-13 | 29.56% (274) | transmembrane serine/threonine-protein kinase J |
| M. gilvum PYR-GCK | Mflv_2235 | - | 6e-07 | 23.90% (251) | putative lipoprotein LppH |
| M. tuberculosis H37Rv | Rv2088 | pknJ | 2e-13 | 29.56% (274) | transmembrane serine/threonine-protein kinase J |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0358 | - | 1e-08 | 26.20% (187) | membrane protein PknM or lipoprotein LppH |
| M. marinum M | MMAR_2444 | - | 1e-13 | 28.42% (278) | transmembrane serine/threonine-protein kinase |
| M. avium 104 | MAV_2123 | - | 3e-12 | 28.22% (241) | PknM protein |
| M. thermoresistible (build 8) | TH_3756 | - | 3e-10 | 26.79% (224) | PUTATIVE putative conserved lipoprotein LppH |
| M. ulcerans Agy99 | MUL_4150 | lppH | 1e-11 | 27.06% (255) | lipoprotein LppH |
| M. vanbaalenii PYR-1 | Mvan_4738 | - | 7e-14 | 26.57% (271) | putative lipoprotein LppH |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2235|M.gilvum_PYR-GCK --------------------------------------------------
TH_3756|M.thermoresistible__bu --------------------------------------------------
Mvan_4738|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2123|M.avium_104 --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
Mb2115|M.bovis_AF2122/97 ---MAHELSAGSVFAGYRIERMLGAGGMGTVYLARNPDLPRSEALKVLAA
Rv2088|M.tuberculosis_H37Rv ---MAHELSAGSVFAGYRIERMLGAGGMGTVYLARNPDLPRSEALKVLAA
MMAR_2444|M.marinum_M MSDTVPTSRVGTQFGPYRLRRLLGRGGMGEVYEAHDTVKDRTVALKLMSQ
MSMEG_4595|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0358|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_2235|M.gilvum_PYR-GCK --------------------------------------------------
TH_3756|M.thermoresistible__bu --------------------------------------------------
Mvan_4738|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2123|M.avium_104 --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
Mb2115|M.bovis_AF2122/97 ELSRDLDFRARFVREADVAAGLDHPNIVAVHQRGQFEGRLWIAMQFVDGG
Rv2088|M.tuberculosis_H37Rv ELSRDLDFRARFVREADVAAGLDHPNIVAVHQRGQFEGRLWIAMQFVDGG
MMAR_2444|M.marinum_M QFNSDSTFRRRMQREAHTAGRLQEPHIVPIHDFGEIDGQLFIDMRFIEGT
MSMEG_4595|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0358|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_2235|M.gilvum_PYR-GCK --------------------------------------------------
TH_3756|M.thermoresistible__bu --------------------------------------------------
Mvan_4738|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2123|M.avium_104 --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
Mb2115|M.bovis_AF2122/97 NAEDALRAATMTTARAVYVIGEVAKALDYAHQQGVIHRDIKPANFLLSRA
Rv2088|M.tuberculosis_H37Rv NAEDALRAATMTTARAVYVIGEVAKALDYAHQQGVIHRDIKPANFLLSRA
MMAR_2444|M.marinum_M DLGSVLKRGALPAPRAVAIVSQVAEALDAAHRGGVVHRDIKPENILITG-
MSMEG_4595|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0358|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_2235|M.gilvum_PYR-GCK --------------------------------------------------
TH_3756|M.thermoresistible__bu --------------------------------------------------
Mvan_4738|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2123|M.avium_104 --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
Mb2115|M.bovis_AF2122/97 AGGDERVLLSDFGIARALGDTGLTSTGSVLATLAYAAPEVLAGQGFDGRA
Rv2088|M.tuberculosis_H37Rv AGGDERVLLSDFGIARALGDTGLTSTGSVLATLAYAAPEVLAGQGFDGRA
MMAR_2444|M.marinum_M ---NDFAYLVDFGIAAAATDQHLTKTGTAVGSWSYMAPERFGDDEVTYRS
MSMEG_4595|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0358|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_2235|M.gilvum_PYR-GCK --------------------------------------------------
TH_3756|M.thermoresistible__bu --------------------------------------------------
Mvan_4738|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2123|M.avium_104 --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
Mb2115|M.bovis_AF2122/97 DLYSLGCALFRLLTGEAPFAAGAGAAVAVVAGHLHQPPPTVSDRVPGLSA
Rv2088|M.tuberculosis_H37Rv DLYSLGCALFRLLTGEAPFAAGAGAAVAVVAGHLHQPPPTVSDRVPGLSA
MMAR_2444|M.marinum_M DIYALACVLYECLTGTPPYQTQN--LSTLMGAHLMQPIPRPSRHRPDIPT
MSMEG_4595|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0358|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_2235|M.gilvum_PYR-GCK --------------------------------------------------
TH_3756|M.thermoresistible__bu --------------------------------------------------
Mvan_4738|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2123|M.avium_104 --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
Mb2115|M.bovis_AF2122/97 AMDAVIATAMAKDPMRRFTSAGEFAHAAAAALYGGATDGWVPPSPAPHVI
Rv2088|M.tuberculosis_H37Rv AMDAVIATAMAKDPMRRFTSAGEFAHAAAAALYGGATDGWVPPSPAPHVI
MMAR_2444|M.marinum_M AFDEVIARGMAKDPALRYPTAGELARAARQALSAGDQERAATLIAGTHQL
MSMEG_4595|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0358|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_2235|M.gilvum_PYR-GCK ------------------------------------------MRRAVAIA
TH_3756|M.thermoresistible__bu --------------------------------------------------
Mvan_4738|M.vanbaalenii_PYR-1 ---------------------------------------MREHTAALTVA
MAV_2123|M.avium_104 -----------------------------------------MRRLAATLA
MUL_4150|M.ulcerans_Agy99 -------------------------------------MRQRVAALAALVG
Mb2115|M.bovis_AF2122/97 SQGAVPGSPWWQHPVGSVTALATPPGHGWPPGLPPLPRRPRRYRRGVAAV
Rv2088|M.tuberculosis_H37Rv SQGAVPGSPWWQHPVGSVTALATPPGHGWPPGLPPLPRRPRRYRRGVAAV
MMAR_2444|M.marinum_M AAPPSGPMPWAPPPWTSP--------------------ARRTRTPWLLAV
MSMEG_4595|M.smegmatis_MC2_155 ----------------------------------MLPSPPNKGRKKKWVL
MAB_0358|M.abscessus_ATCC_1997 ------------------------------------------MGVASYLC
Mflv_2235|M.gilvum_PYR-GCK GIAIMVTGCASTS-------------SAESAEPP--TRTMIPRP--LVER
TH_3756|M.thermoresistible__bu -MGVLVAGCGSTG-------------HAESTTAPSTTKTLIPRP--LVER
Mvan_4738|M.vanbaalenii_PYR-1 ATCVLVAACGGGGNEGATSTTPSTLLSPTTSAPAPPTTSTPPPP--VAES
MAV_2123|M.avium_104 AAGMLVAGCGAGN------------HGAASSSTATGSTASPKTP--LARG
MUL_4150|M.ulcerans_Agy99 GAGMLVTGCTNIV--------------DGNAVAADMSGPLNQTP--IAVS
Mb2115|M.bovis_AF2122/97 AAVMVVAAAAVTAVTMTSHQPRTATPPSAAALSPTSSSTTPPQPPIVTRS
Rv2088|M.tuberculosis_H37Rv AAVMVVAAAAVTAVTMTSHQPRTATPPSAAALSPTSSSTTPPQPPIVTRS
MMAR_2444|M.marinum_M AVLVVVIVVVGTGIFLARKEPASGPTGGVSTTAGAPSGITATAGPTVAPT
MSMEG_4595|M.smegmatis_MC2_155 GVAAVAAAVGVAGVGVVNLRSDDRSESEPLAHPTSTTPAPPRVDSGLPVT
MAB_0358|M.abscessus_ATCC_1997 VLAMTVASAG--------------------------TASANPDELPVQTE
. : :
Mflv_2235|M.gilvum_PYR-GCK EIGEVLLSPEEIAALMGVPAMTVIEAQTSLSDH--SDI--MAPIE---CL
TH_3756|M.thermoresistible__bu ELPGLLLSPEQVNAAMGTTDMAIISSQTSLSDH--SNT--MAPPE---CL
Mvan_4738|M.vanbaalenii_PYR-1 ALDGLLLSPAEIDTVVGATGMAVAGTSTSLAED--ITVPPDAPEEKKACV
MAV_2123|M.avium_104 ALPDLMLSPNDIDTALGVTGTTSDPPFTALGEDPVRRTDYTFPAE---CK
MUL_4150|M.ulcerans_Agy99 ALDDLLLDVSQIDSALGATSMKVWFNAKAMWDWS-------KNISDKNCL
Mb2115|M.bovis_AF2122/97 RLPGLLPPLDDVKNFVGIQNLVAHEPMLQPQTPN-------GSINPAECW
Rv2088|M.tuberculosis_H37Rv RLPGLLPPLDDVKNFVGIQNLVAHEPMLQPQTPN-------GSINPAECW
MMAR_2444|M.marinum_M QLESFLLSPEQINTIVGTTGIVIDHNATEMTDPG-----PENSLSTEQCL
MSMEG_4595|M.smegmatis_MC2_155 ALPNLLLTPAEMNAALGTSRFEAPPPTNQLNQN---------ASSHPQCG
MAB_0358|M.abscessus_ATCC_1997 ALSSLMLEPGDVAPVMGAGMYVAGDWAALVSDRT------DRPECGSVVL
: .: :: :*
Mflv_2235|M.gilvum_PYR-GCK AIDGAGELQVYANSDYRASR--------DQSLN--DGEGWKTY-VKQAVV
TH_3756|M.thermoresistible__bu ALDGAGEADVYADSGYRAAR--------DHSLN--NGDNFTHY-AKQAVV
Mvan_4738|M.vanbaalenii_PYR-1 GIAGTAEAQAYAGSGSTAVR--------DQALRAPNDSGATLS-AGQAVV
MAV_2123|M.avium_104 YTTHAGLASEYAGSGSTAVYGYH-----DLAPTPAGANQLESPEVYQFVV
MUL_4150|M.ulcerans_Agy99 AVDGPAQDEVYAGTGWTAMRG-------QRMDDSVDDSKRRKHYAIQAVV
Mb2115|M.bovis_AF2122/97 PAVGGGVPSAYDLGTVIGFYG---------LTIDEPPTGTAPNQVGQLIV
Rv2088|M.tuberculosis_H37Rv PAVGGGVPSAYDLGTVIGFYG---------LTIDEPPTGTAPNQVGQLIV
MMAR_2444|M.marinum_M GALIGYQTRTYKSSGYTGMLA----------QLMQKPRSTPGYVVVQGAV
MSMEG_4595|M.smegmatis_MC2_155 AVVEVGLRSAYEGSGYRAVQFQYGQNEEPSGDPLADAFGSPLVRVGQMVT
MAB_0358|M.abscessus_ATCC_1997 ASGASYESSNYLSGRYRSLID----------------SPNWTRLVDQSMV
* . . * .
Mflv_2235|M.gilvum_PYR-GCK LFPYLEKAGEFFDASVAQWPACR--EYTHTQSGSV----WNPGEIT-SAD
TH_3756|M.thermoresistible__bu LFPLAETARAFFEASAEQWPACH--EYRHTQSGTK----WYVAELT-RDG
Mvan_4738|M.vanbaalenii_PYR-1 LFPTADEAATFFAESAQKWPLCR--GYN--AGGSP----VTVGDVS-SDN
MAV_2123|M.avium_104 LFPSPEQASAFLSASSARWPACANRQDTVPADGTNPELRWKVGPVT-NAN
MUL_4150|M.ulcerans_Agy99 AFPSAHDASAFYNSSVRSWGNCSNRRFTDVSTDQP-DTIWTVSDVV-NDN
Mb2115|M.bovis_AF2122/97 AFRDAATAQRHLADLASIWRRCGGRTVTLFRSEWR----RPVELST-SVP
Rv2088|M.tuberculosis_H37Rv AFRDAATAQRHLADLASIWRRCGGRTVTLFRSEWR----RPVELST-SVP
MMAR_2444|M.marinum_M IFASADQAVGFVAAQADQWRSCAGKDVTQVNNGKT--SRWTFREVS-GAP
MSMEG_4595|M.smegmatis_MC2_155 AFPDATAASKFVADQSGKWRQCTHTGAVSLIVEGQPNTDFHVSEVPQNDK
MAB_0358|M.abscessus_ATCC_1997 IFPEWSDATDFALAEADRWRACENQRVTSLLPQPD--GSTRREWVQLRKI
* * . * *
Mflv_2235|M.gilvum_PYR-GCK RTLS---TVAMQRDAAA-PGWGCGRALVHRNNVIVDVNTCS---AAPGDS
TH_3756|M.thermoresistible__bu DILK---AITVQRDAGH-PGWGCGRALVLRNNIIGDVNTCS---ADPGDS
Mvan_4738|M.vanbaalenii_PYR-1 GMLV---TSITIQSEDE-PTL-CERALTMKNNIVIDVSTCG---GSS-DS
MAV_2123|M.avium_104 GMLSSQVTVTVNGNGVN-VTMPCQRALTARNNIVIDVDACR---KDVGDL
MUL_4150|M.ulcerans_Agy99 GMLS-----TSQVQEAG-DGWTCQRALTVRNNVAIDVVTCAY--SQSGSV
Mb2115|M.bovis_AF2122/97 EVVDGITTMVLTAQGPV-LRVREDHAIAAKNNVLVDVDIMTPDTSRGQQA
Rv2088|M.tuberculosis_H37Rv EVVDGITTMVLTAQGPV-LRVREDHAIAAKNNVLVDVDIMTPDTSRGQQA
MMAR_2444|M.marinum_M PKIS------LQRDLAD-SVVVCQHVLSAVSNIVLDVNVCAP---NVTDQ
MSMEG_4595|M.smegmatis_MC2_155 HTVQGVLTMELYYAGPQRGNWNCYHSLGAQRNIVADVMVCDG--QVKHYQ
MAB_0358|M.abscessus_ATCC_1997 VQVQEVLVVGYTWPTDFGGVIYCQHALAPLRNVAIDVRACAE---RDGSR
: : : *: **
Mflv_2235|M.gilvum_PYR-GCK AVRIAHQIADKVDAQW
TH_3756|M.thermoresistible__bu AVRIAQQIGENVDAVW
Mvan_4738|M.vanbaalenii_PYR-1 AVRIADQIAARVPGE-
MAV_2123|M.avium_104 GIDIAKQIAGKVDKQ-
MUL_4150|M.ulcerans_Agy99 AADVAQQIAAKAAKQ-
Mb2115|M.bovis_AF2122/97 VIGITNYILAKIPG--
Rv2088|M.tuberculosis_H37Rv VIGITNYILAKIPG--
MMAR_2444|M.marinum_M ASEIADTMAAKVPT--
MSMEG_4595|M.smegmatis_MC2_155 SAKIVERILAKVPAT-
MAB_0358|M.abscessus_ATCC_1997 ALDLILGLLPRVARA-
: : .