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VGKQLAALAALVGACMLAAGCTNVVDGTAVAADKSGPLHQDPIPVSALEGLLLDLSQINAALGATSMKVW FNAKAMWDWSKSVADKNCLAIDGPAQEKVYAGTGWTAMRGQRLDDSIDDSKKRDHYAIQAVVGFPTAHDA EEFYSSSVQSWSSCSNRRFVEVTPGQDDAAWTVADVVNDNGMLSSSQVQEGGDGWTCQRALTARNNVTID IVTCAYSQPDLVAIGIANQIAAKVAKQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3576 | lppH | - | 100% (237) | POSSIBLE CONSERVED LIPOPROTEIN LPPH |
| M. tuberculosis H37Rv | Rv1266c | pknH | 1e-26 | 35.23% (193) | transmembrane serine/threonine-protein kinase H |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3607 | lppH | 1e-136 | 99.58% (237) | lipoprotein LppH |
| M. gilvum PYR-GCK | Mflv_2675 | - | 1e-29 | 35.47% (203) | hypothetical protein Mflv_2675 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2420c | - | 5e-09 | 27.56% (156) | hypothetical protein MAB_2420c |
| M. marinum M | MMAR_5074 | lppH | 1e-104 | 74.79% (238) | lipoprotein LppH |
| M. avium 104 | MAV_1417 | - | 5e-27 | 34.36% (227) | serine/threonine-protein kinase PknE |
| M. smegmatis MC2 155 | MSMEG_4554 | - | 4e-19 | 29.00% (231) | serine/threonine-protein kinase PknH, putative |
| M. thermoresistible (build 8) | TH_3756 | - | 7e-30 | 35.59% (222) | PUTATIVE putative conserved lipoprotein LppH |
| M. ulcerans Agy99 | MUL_4150 | lppH | 1e-104 | 75.21% (238) | lipoprotein LppH |
| M. vanbaalenii PYR-1 | Mvan_3878 | - | 2e-32 | 33.78% (225) | hypothetical protein Mvan_3878 |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3576|M.tuberculosis_H37Rv --------------------------------------------------
Mb3607|M.bovis_AF2122/97 --------------------------------------------------
MMAR_5074|M.marinum_M --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
TH_3756|M.thermoresistible__bu --------------------------------------------------
Mflv_2675|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3878|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4554|M.smegmatis_MC2_155 --------------------------------------------------
MAV_1417|M.avium_104 MSDERSSKVGSMFGPYHLKRLLGRGGMGEVYEAEHTVKEWTVAVKLLNES
MAB_2420c|M.abscessus_ATCC_199 --------------------------------------------------
Rv3576|M.tuberculosis_H37Rv --------------------------------------------------
Mb3607|M.bovis_AF2122/97 --------------------------------------------------
MMAR_5074|M.marinum_M --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
TH_3756|M.thermoresistible__bu --------------------------------------------------
Mflv_2675|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3878|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4554|M.smegmatis_MC2_155 --------------------------------------------------
MAV_1417|M.avium_104 FSSDPVFRERMKREARTAGRLQEPHVVPVHDYGEIDGQMFLEMRLVEGTD
MAB_2420c|M.abscessus_ATCC_199 --------------------------------------------------
Rv3576|M.tuberculosis_H37Rv --------------------------------------------------
Mb3607|M.bovis_AF2122/97 --------------------------------------------------
MMAR_5074|M.marinum_M --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
TH_3756|M.thermoresistible__bu --------------------------------------------------
Mflv_2675|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3878|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4554|M.smegmatis_MC2_155 --------------------------------------------------
MAV_1417|M.avium_104 LDSVLKRFGPLPPPRAVAIITQIASALDAAHAAGVMHRDVKPQNILVTRD
MAB_2420c|M.abscessus_ATCC_199 --------------------------------------------------
Rv3576|M.tuberculosis_H37Rv --------------------------------------------------
Mb3607|M.bovis_AF2122/97 --------------------------------------------------
MMAR_5074|M.marinum_M --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
TH_3756|M.thermoresistible__bu --------------------------------------------------
Mflv_2675|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3878|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4554|M.smegmatis_MC2_155 --------------------------------------------------
MAV_1417|M.avium_104 DFAYLVDFGIASATTDEKLTQLGTAVGTWKYMAPERFSDAEVTYRADIYA
MAB_2420c|M.abscessus_ATCC_199 --------------------------------------------------
Rv3576|M.tuberculosis_H37Rv --------------------------------------------------
Mb3607|M.bovis_AF2122/97 --------------------------------------------------
MMAR_5074|M.marinum_M --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
TH_3756|M.thermoresistible__bu --------------------------------------------------
Mflv_2675|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3878|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4554|M.smegmatis_MC2_155 --------------------------------------------------
MAV_1417|M.avium_104 LACVLFECLTGSAPYRADSAGVLVSAHVMDPIPAPSARRPGVPKAFDAVI
MAB_2420c|M.abscessus_ATCC_199 --------------------------------------------------
Rv3576|M.tuberculosis_H37Rv --------------------------------------------------
Mb3607|M.bovis_AF2122/97 --------------------------------------------------
MMAR_5074|M.marinum_M --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
TH_3756|M.thermoresistible__bu --------------------------------------------------
Mflv_2675|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3878|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4554|M.smegmatis_MC2_155 --------------------------------------------------
MAV_1417|M.avium_104 ARGMAKKPEDRYASAGDLALAAKEALSTPDQDRAATILRRSQEAALPAAG
MAB_2420c|M.abscessus_ATCC_199 --------------------------------------------------
Rv3576|M.tuberculosis_H37Rv --------------------------------------------------
Mb3607|M.bovis_AF2122/97 --------------------------------------------------
MMAR_5074|M.marinum_M --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
TH_3756|M.thermoresistible__bu --------------------------------------------------
Mflv_2675|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3878|M.vanbaalenii_PYR-1 ---------MADNGLVNNVGAVRCAYAAG---------------------
MSMEG_4554|M.smegmatis_MC2_155 ---------------MTPGRRWTRLCTAG---------------------
MAV_1417|M.avium_104 QRDAGASTVLAPPPAVNTRQPGSAASQAGRGWTPESGPIPAAGQPGPPYY
MAB_2420c|M.abscessus_ATCC_199 -------MLAAGWLGLATMLAVSCGTQSG---------------------
Rv3576|M.tuberculosis_H37Rv ---------------------MGKQLAALAALVG-ACMLAAGCTNVVDGT
Mb3607|M.bovis_AF2122/97 ---------------------MGKQLAALAALVG-ACMLAAGCTNVVDGT
MMAR_5074|M.marinum_M ---------------------MRQRVAALAALVGGAGMLVTGCTNIVDGN
MUL_4150|M.ulcerans_Agy99 ---------------------MRQRVAALAALVGGAGMLVTGCTNIVDGN
TH_3756|M.thermoresistible__bu -----------------------------------MGVLVAGCGSTGHAE
Mflv_2675|M.gilvum_PYR-GCK --------------------------------MTALMLPMTACVETVDGT
Mvan_3878|M.vanbaalenii_PYR-1 -------------------------------AGLAASVLLCACVSTVEGA
MSMEG_4554|M.smegmatis_MC2_155 -------------------------------AAAAVMCLLSGCVTVVGGT
MAV_1417|M.avium_104 QGGNANWAAAPAQFAGPPPWGRPPPKRRVWPIVAAVVAVLVVIAGGVGVW
MAB_2420c|M.abscessus_ATCC_199 --------------------GIKPIPVGATETSAAADKGADAAIASPKSS
Rv3576|M.tuberculosis_H37Rv AVAAD-KSGPLHQDPIPVSALEGLLLDLSQINAALGATSMKVWFNAKAMW
Mb3607|M.bovis_AF2122/97 AVAAD-KSGPLHQDPIPVSALEGLLLDLSQINAALGATSMKVWFNAKAMW
MMAR_5074|M.marinum_M AVAAD-MSGPLNQTPIAVSALDDLLLDVNQIDSALGATSMKVWFNAKAMW
MUL_4150|M.ulcerans_Agy99 AVAAD-MSGPLNQTPIAVSALDDLLLDVSQIDSALGATSMKVWFNAKAMW
TH_3756|M.thermoresistible__bu STTAPSTTKTLIPRPLVERELPGLLLSPEQVNAAMGTTDMAIISSQTSLS
Mflv_2675|M.gilvum_PYR-GCK ALRGHGAGLTD-VAPLDESRLDSVLVGIDEINSIMGATGMEVTGELDEMS
Mvan_3878|M.vanbaalenii_PYR-1 AVRHPGAATLD-VPPLDEAALDRVLLSVDELNSIMGSIRMKVSSELDEMT
MSMEG_4554|M.smegmatis_MC2_155 ATRDP-AAPPP-GAAVTEVDLDNLLLPVTELGDIVGSDDLTVTVELDQFN
MAV_1417|M.avium_104 LVIRPKPEPPQ-AAPLTSDRLGALLLSASEVNAVMGSSTMEPGKPITATD
MAB_2420c|M.abscessus_ATCC_199 APPVTTSLEPPAPVIVTPDKAESIIISADDAGRLVGSP----LTYERKSS
: ::: : . :*:
Rv3576|M.tuberculosis_H37Rv DWSKSVADKNCLAIDGPAQEKVYAGTGWTAMRGQRLDDSIDDSKKRDHYA
Mb3607|M.bovis_AF2122/97 DWSKSVADKNCLAIDGPAQEKVYAGTGWTAMRGQRLDDSINDSKKRDHYA
MMAR_5074|M.marinum_M DWSKNISDKNCLAVDGPAQDEVYAGTGWTAMRGQRMDDSVDDSKRRKHYA
MUL_4150|M.ulcerans_Agy99 DWSKNISDKNCLAVDGPAQDEVYAGTGWTAMRGQRMDDSVDDSKRRKHYA
TH_3756|M.thermoresistible__bu DHSNTMAPPECLALDGAGEADVYADSGYRAAR----DHSLNNGDNFTHYA
Mflv_2675|M.gilvum_PYR-GCK DHSADVSDPDCLGAVYGAEAPVYEGTDWTAVRDQVAREPGAGND---HWV
Mvan_3878|M.vanbaalenii_PYR-1 DHTAEVSNPDCLGTVYAAEEPAYAGTGWTAVRDQVAREPDGDND---HWV
MSMEG_4554|M.smegmatis_MC2_155 DSSAAMDDPDCLAAAFGAQERVYAGTGWTAVRDQIVREPGSFSP---HWI
MAV_1417|M.avium_104 SSSVTVSVPDCQGALYTTQDPVYAGSGYSAVNGLVSSEPGDNYD---HWV
MAB_2420c|M.abscessus_ATCC_199 SPSDSLASGKCQALTG--LRTESLGDEWTTYRGARQQETEKRYD---HIV
. : : .* . . : : . .. *
Rv3576|M.tuberculosis_H37Rv IQAVVGFPTAHDAEEFYSSSV-QSWSSCSNRRFVEVTPGQDDAAWTVADV
Mb3607|M.bovis_AF2122/97 IQAVVGFPTAHDAEEFYSSSV-QSWSSCSNRRFVEVTPGQDDAAWTVADV
MMAR_5074|M.marinum_M IQAVVAFPSAHDASAFYNSSV-RSWGNCSNRRFTDVSTDQPDTIWTVSDV
MUL_4150|M.ulcerans_Agy99 IQAVVAFPSAHDASAFYNSSV-RSWGNCSNRRFTDVSTDQPDTIWTVSDV
TH_3756|M.thermoresistible__bu KQAVVLFPLAETARAFFEASA-EQWPACHEYRHTQSG-----TKWYVAEL
Mflv_2675|M.gilvum_PYR-GCK EQAVVLYPEERNARDFLESSQ-AVWRDCAN---NALGVG--DYLWELGAV
Mvan_3878|M.vanbaalenii_PYR-1 EQTAVIYPAARNAQDFFDRSS-VTWQDCAN---ATITTGDGDYLWELDAA
MSMEG_4554|M.smegmatis_MC2_155 EQVVVLFTSDLHARDFFDQSR-ETWRGCVGT-LTTYDIDQMPLEWVVGEV
MAV_1417|M.avium_104 NQAVVLFPSADKAKSFLQTSL-QKWKGCAGQ-TVTVTNKSKTYRWTFAQV
MAB_2420c|M.abscessus_ATCC_199 WQSVVLFPDPKSAASQLQAAYPRSLSSCAGS-----RQTEGDDEWQIGDI
* .* :. * . : * * .
Rv3576|M.tuberculosis_H37Rv VNDNGMLSSSQVQ---EGGDGWTCQRALTARNNVTIDIVTCAYSQPDLVA
Mb3607|M.bovis_AF2122/97 VNDNGMLSSSQVQ---EGGDGWTCQRALTARNNVTIDIVTCAYSQPDLVA
MMAR_5074|M.marinum_M VNDNGMLSTSQVQ---EAGDGWTCQRALTVRNNVAIDVVTCAYSQSGSVA
MUL_4150|M.ulcerans_Agy99 VNDNGMLSTSQVQ---EAGDGWTCQRALTVRNNVAIDVVTCAYSQSGSVA
TH_3756|M.thermoresistible__bu TRDGDILKAITVQR-DAGHPGWGCGRALVLRNNIIGDVNTCSAD-PGDSA
Mflv_2675|M.gilvum_PYR-GCK EAADLMLTQVTTQ---EGADGWSCQHALSLVSNVTVEAWACGYDITDEAA
Mvan_3878|M.vanbaalenii_PYR-1 QVDDTVLTQRVTQ---DGADGWACQHALSVVSNLTVEAWACGYSISDEAA
MSMEG_4554|M.smegmatis_MC2_155 TAEESTISQLSVP---ETAVRGGCHHALSVAANLVAEAWACGEGVEDQAS
MAV_1417|M.avium_104 QGAPPKITLMDTQ---EGADGWECQRALSVANNVIVDINACGYRITDQGD
MAB_2420c|M.abscessus_ATCC_199 VNDGTSVKWTRQETPNGKPSGWRCFYDYRVKNNALFGSLLCQNGNGAPIV
:. * * *
Rv3576|M.tuberculosis_H37Rv IGIANQIAAKVAKQ-
Mb3607|M.bovis_AF2122/97 IGIANQIAAKVAKQ-
MMAR_5074|M.marinum_M ADVAQQIAAKAAKQ-
MUL_4150|M.ulcerans_Agy99 ADVAQQIAAKAAKQ-
TH_3756|M.thermoresistible__bu VRIAQQIGENVDAVW
Mflv_2675|M.gilvum_PYR-GCK R-IADAMIRNAAG--
Mvan_3878|M.vanbaalenii_PYR-1 E-IAVAMIENAATK-
MSMEG_4554|M.smegmatis_MC2_155 E-IVDQIVANIE---
MAV_1417|M.avium_104 Q-IADKIVAKIDNE-
MAB_2420c|M.abscessus_ATCC_199 SAIVDRMAEWIPA--
:. :