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IPVAPLRRRRPSPLTLAAIVATVVALALAAAAVVVSVSGIGNVPSAALKGLLLTPQEVAKAHGAQAIEVI SDDDSLDSNEPDSECLGLLNDRAERAYRGSGWRAVHHQSLADQARHVMFSQSLIAMSDIHGAARYVDEQH ALWKVCSAQVLHRKNEDGLVADYVVTMVKRSDGILAASYHRDGGDGRTCVRGMAWRRNVVIDVTTCGPGP TLWRLPGIIVPISARIQEA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4597 | lppH | - | 100% (230) | putative lipoprotein lpph |
| M. smegmatis MC2 155 | MSMEG_4598 | lppH | 1e-12 | 28.37% (215) | putative lipoprotein lpph |
| M. smegmatis MC2 155 | MSMEG_4595 | - | 5e-09 | 26.34% (205) | serine/threonine-protein kinase PknH, putative |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3607 | lppH | 1e-17 | 29.13% (230) | lipoprotein LppH |
| M. gilvum PYR-GCK | Mflv_2675 | - | 6e-10 | 23.65% (203) | hypothetical protein Mflv_2675 |
| M. tuberculosis H37Rv | Rv3576 | lppH | 1e-17 | 29.13% (230) | lipoprotein LppH |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0361 | - | 4e-11 | 27.23% (213) | hypothetical protein MAB_0361 |
| M. marinum M | MMAR_5074 | lppH | 7e-15 | 29.03% (186) | lipoprotein LppH |
| M. avium 104 | MAV_1417 | - | 7e-10 | 25.35% (217) | serine/threonine-protein kinase PknE |
| M. thermoresistible (build 8) | TH_3756 | - | 2e-11 | 29.17% (168) | PUTATIVE putative conserved lipoprotein LppH |
| M. ulcerans Agy99 | MUL_4150 | lppH | 5e-15 | 29.03% (186) | lipoprotein LppH |
| M. vanbaalenii PYR-1 | Mvan_4738 | - | 3e-12 | 29.94% (177) | putative lipoprotein LppH |
CLUSTAL 2.0.9 multiple sequence alignment
TH_3756|M.thermoresistible__bu --------------------------------------------------
Mvan_4738|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb3607|M.bovis_AF2122/97 --------------------------------------------------
Rv3576|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_5074|M.marinum_M --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
Mflv_2675|M.gilvum_PYR-GCK --------------------------------------------------
MAV_1417|M.avium_104 MSDERSSKVGSMFGPYHLKRLLGRGGMGEVYEAEHTVKEWTVAVKLLNES
MSMEG_4597|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0361|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3756|M.thermoresistible__bu --------------------------------------------------
Mvan_4738|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb3607|M.bovis_AF2122/97 --------------------------------------------------
Rv3576|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_5074|M.marinum_M --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
Mflv_2675|M.gilvum_PYR-GCK --------------------------------------------------
MAV_1417|M.avium_104 FSSDPVFRERMKREARTAGRLQEPHVVPVHDYGEIDGQMFLEMRLVEGTD
MSMEG_4597|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0361|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3756|M.thermoresistible__bu --------------------------------------------------
Mvan_4738|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb3607|M.bovis_AF2122/97 --------------------------------------------------
Rv3576|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_5074|M.marinum_M --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
Mflv_2675|M.gilvum_PYR-GCK --------------------------------------------------
MAV_1417|M.avium_104 LDSVLKRFGPLPPPRAVAIITQIASALDAAHAAGVMHRDVKPQNILVTRD
MSMEG_4597|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0361|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3756|M.thermoresistible__bu --------------------------------------------------
Mvan_4738|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb3607|M.bovis_AF2122/97 --------------------------------------------------
Rv3576|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_5074|M.marinum_M --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
Mflv_2675|M.gilvum_PYR-GCK --------------------------------------------------
MAV_1417|M.avium_104 DFAYLVDFGIASATTDEKLTQLGTAVGTWKYMAPERFSDAEVTYRADIYA
MSMEG_4597|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0361|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3756|M.thermoresistible__bu --------------------------------------------------
Mvan_4738|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb3607|M.bovis_AF2122/97 --------------------------------------------------
Rv3576|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_5074|M.marinum_M --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
Mflv_2675|M.gilvum_PYR-GCK --------------------------------------------------
MAV_1417|M.avium_104 LACVLFECLTGSAPYRADSAGVLVSAHVMDPIPAPSARRPGVPKAFDAVI
MSMEG_4597|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0361|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3756|M.thermoresistible__bu --------------------------------------------------
Mvan_4738|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb3607|M.bovis_AF2122/97 --------------------------------------------------
Rv3576|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_5074|M.marinum_M --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
Mflv_2675|M.gilvum_PYR-GCK --------------------------------------------------
MAV_1417|M.avium_104 ARGMAKKPEDRYASAGDLALAAKEALSTPDQDRAATILRRSQEAALPAAG
MSMEG_4597|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0361|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3756|M.thermoresistible__bu -------------MGVLVAGCGSTGH--AESTT-----------------
Mvan_4738|M.vanbaalenii_PYR-1 -MREHTAALTVAATCVLVAACGGGGNEGATSTTPST--------------
Mb3607|M.bovis_AF2122/97 ---------MGKQLAALAALVG-ACMLAAGCTN-----------------
Rv3576|M.tuberculosis_H37Rv ---------MGKQLAALAALVG-ACMLAAGCTN-----------------
MMAR_5074|M.marinum_M ---------MRQRVAALAALVGGAGMLVTGCTN-----------------
MUL_4150|M.ulcerans_Agy99 ---------MRQRVAALAALVGGAGMLVTGCTN-----------------
Mflv_2675|M.gilvum_PYR-GCK -----MTALMLPMTACVETVDGTALRGHGAGLT-----------------
MAV_1417|M.avium_104 QRDAGASTVLAPPPAVNTRQPGSAASQAGRGWTPESGPIPAAGQPGPPYY
MSMEG_4597|M.smegmatis_MC2_155 ----------MIPVAPLRRRRPSPLTLAAIVAT-----------------
MAB_0361|M.abscessus_ATCC_1997 ------------MTIVLSAALACAAPALAEQGS-----------------
.
TH_3756|M.thermoresistible__bu --------------------------------------------------
Mvan_4738|M.vanbaalenii_PYR-1 -------------------------------------------LLSPTTS
Mb3607|M.bovis_AF2122/97 ---------------------------------------------VVDGT
Rv3576|M.tuberculosis_H37Rv ---------------------------------------------VVDGT
MMAR_5074|M.marinum_M ---------------------------------------------IVDGN
MUL_4150|M.ulcerans_Agy99 ---------------------------------------------IVDGN
Mflv_2675|M.gilvum_PYR-GCK --------------------------------------------------
MAV_1417|M.avium_104 QGGNANWAAAPAQFAGPPPWGRPPPKRRVWPIVAAVVAVLVVIAGGVGVW
MSMEG_4597|M.smegmatis_MC2_155 --------------------------------------------VVALAL
MAB_0361|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3756|M.thermoresistible__bu --APSTTKTLIPRPLVERELPGLLLSPEQVNAAMGTTDMAIISSQTSLSD
Mvan_4738|M.vanbaalenii_PYR-1 APAPPTTSTPPP-PVAESALDGLLLSPAEIDTVVGATGMAVAGTSTSLAE
Mb3607|M.bovis_AF2122/97 AVAADKSGPLHQDPIPVSALEGLLLDLSQINAALGATSMKVWFNAKAMWD
Rv3576|M.tuberculosis_H37Rv AVAADKSGPLHQDPIPVSALEGLLLDLSQINAALGATSMKVWFNAKAMWD
MMAR_5074|M.marinum_M AVAADMSGPLNQTPIAVSALDDLLLDVNQIDSALGATSMKVWFNAKAMWD
MUL_4150|M.ulcerans_Agy99 AVAADMSGPLNQTPIAVSALDDLLLDVSQIDSALGATSMKVWFNAKAMWD
Mflv_2675|M.gilvum_PYR-GCK ----------DVAPLDESRLDSVLVGIDEINSIMGATGMEVTGELDEMSD
MAV_1417|M.avium_104 LVIRPKPEPPQAAPLTSDRLGALLLSASEVNAVMGSSTMEPGKPITATDS
MSMEG_4597|M.smegmatis_MC2_155 AAAAVVVSVSGIGNVPSAALKGLLLTPQEVAKAHGAQAIEVISDDDSLDS
MAB_0361|M.abscessus_ATCC_1997 -------------PIPPAAIDDLMVTPDEASSVM-KTGFPVVDRFNALSA
: : ::: : :
TH_3756|M.thermoresistible__bu HSNT--MAPPE---CLALDGAGEADVYADSGYRAARDHSLN--NGDNFT-
Mvan_4738|M.vanbaalenii_PYR-1 DITVPPDAPEEKKACVGIAGTAEAQAYAGSGSTAVRDQALRAPNDSGAT-
Mb3607|M.bovis_AF2122/97 WSKS-----VADKNCLAIDGPAQEKVYAGTGWTAMRGQRLDDSINDSKKR
Rv3576|M.tuberculosis_H37Rv WSKS-----VADKNCLAIDGPAQEKVYAGTGWTAMRGQRLDDSIDDSKKR
MMAR_5074|M.marinum_M WSKN-----ISDKNCLAVDGPAQDEVYAGTGWTAMRGQRMDDSVDDSKRR
MUL_4150|M.ulcerans_Agy99 WSKN-----ISDKNCLAVDGPAQDEVYAGTGWTAMRGQRMDDSVDDSKRR
Mflv_2675|M.gilvum_PYR-GCK HSAD-----VSDPDCLGAVYGAEAPVYEGTDWTAVRDQVAR---EPGAGN
MAV_1417|M.avium_104 SSVT-----VSVPDCQGALYTTQDPVYAGSGYSAVNGLVSS---EPGDNY
MSMEG_4597|M.smegmatis_MC2_155 NEPD--------SECLGLLNDRAERAYRGSGWRAVHHQSLA-----DQAR
MAB_0361|M.abscessus_ATCC_1997 LTTD-------RPDCGSVVLPSVATYDRGP-YMAAHQQYLQ----DSAPW
* . .. * . .
TH_3756|M.thermoresistible__bu -HYAKQAVVLFPLAETARAFFEASAEQWPACHEYRHTQSGTK-----WYV
Mvan_4738|M.vanbaalenii_PYR-1 -LSAGQAVVLFPTADEAATFFAESAQKWPLCRGY--NAGGSP-----VTV
Mb3607|M.bovis_AF2122/97 DHYAIQAVVGFPTAHDAEEFYSSSVQSWSSCSNRRFVEVTPGQDDAAWTV
Rv3576|M.tuberculosis_H37Rv DHYAIQAVVGFPTAHDAEEFYSSSVQSWSSCSNRRFVEVTPGQDDAAWTV
MMAR_5074|M.marinum_M KHYAIQAVVAFPSAHDASAFYNSSVRSWGNCSNRRFTDVSTDQPDTIWTV
MUL_4150|M.ulcerans_Agy99 KHYAIQAVVAFPSAHDASAFYNSSVRSWGNCSNRRFTDVSTDQPDTIWTV
Mflv_2675|M.gilvum_PYR-GCK DHWVEQAVVLYPEERNARDFLESSQAVWRDCANNALGVG-----DYLWEL
MAV_1417|M.avium_104 DHWVNQAVVLFPSADKAKSFLQTSLQKWKGCAGQTVTVTNKSK-TYRWTF
MSMEG_4597|M.smegmatis_MC2_155 HVMFSQSLIAMSDIHGAARYVDEQHALWKVCSAQVLHRKNEDGLVADYVV
MAB_0361|M.abscessus_ATCC_1997 NVQLAQSIAVFPTDDEARDFASTEMDMWLKCSKHTVHDSAQWR----YAI
*:: . * : . * * .
TH_3756|M.thermoresistible__bu AELTRD-GDILKAITVQRDAGHPGWGCGRALVLRNNIIGDVNTCS--ADP
Mvan_4738|M.vanbaalenii_PYR-1 GDVSSDNGMLVTSITIQSED-EPTL-CERALTMKNNIVIDVSTCG--GSS
Mb3607|M.bovis_AF2122/97 ADVVNDNGMLSSSQVQEGGD---GWTCQRALTARNNVTIDIVTCAY-SQP
Rv3576|M.tuberculosis_H37Rv ADVVNDNGMLSSSQVQEGGD---GWTCQRALTARNNVTIDIVTCAY-SQP
MMAR_5074|M.marinum_M SDVVNDNGMLSTSQVQEAGD---GWTCQRALTVRNNVAIDVVTCAY-SQS
MUL_4150|M.ulcerans_Agy99 SDVVNDNGMLSTSQVQEAGD---GWTCQRALTVRNNVAIDVVTCAY-SQS
Mflv_2675|M.gilvum_PYR-GCK GAVEAADLMLTQVTTQEGAD---GWSCQHALSLVSNVTVEAWACG--YDI
MAV_1417|M.avium_104 AQVQGAPPKITLMDTQEGAD---GWECQRALSVANNVIVDINACG--YRI
MSMEG_4597|M.smegmatis_MC2_155 TMVKRSDGILAASYHRDGGD---GRTCVRGMAWRRNVVIDVTTCGP-GPT
MAB_0361|M.abscessus_ATCC_1997 GSLHRDDDAVVGSYVMITNDG-ARMSCSRLLARVRNTATDLRACSAGPES
: : * : : * : :*.
TH_3756|M.thermoresistible__bu GDSAVRIAQQIGENVDAVW
Mvan_4738|M.vanbaalenii_PYR-1 -DSAVRIADQIAARVPGE-
Mb3607|M.bovis_AF2122/97 DLVAIGIANQIAAKVAKQ-
Rv3576|M.tuberculosis_H37Rv DLVAIGIANQIAAKVAKQ-
MMAR_5074|M.marinum_M GSVAADVAQQIAAKAAKQ-
MUL_4150|M.ulcerans_Agy99 GSVAADVAQQIAAKAAKQ-
Mflv_2675|M.gilvum_PYR-GCK TDEAARIADAMIRNAAG--
MAV_1417|M.avium_104 TDQGDQIADKIVAKIDNE-
MSMEG_4597|M.smegmatis_MC2_155 LWRLPGIIVPISARIQEA-
MAB_0361|M.abscessus_ATCC_1997 YQRLLGIAKIIGPRYDAA-
: : .