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MTALMLPMTACVETVDGTALRGHGAGLTDVAPLDESRLDSVLVGIDEINSIMGATGMEVTGELDEMSDHS ADVSDPDCLGAVYGAEAPVYEGTDWTAVRDQVAREPGAGNDHWVEQAVVLYPEERNARDFLESSQAVWRD CANNALGVGDYLWELGAVEAADLMLTQVTTQEGADGWSCQHALSLVSNVTVEAWACGYDITDEAARIADA MIRNAAG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2675 | - | - | 100% (217) | hypothetical protein Mflv_2675 |
| M. gilvum PYR-GCK | Mflv_2235 | - | 4e-21 | 34.64% (179) | putative lipoprotein LppH |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1297c | pknH | 7e-39 | 38.92% (185) | transmembrane serine/threonine-protein kinase H |
| M. tuberculosis H37Rv | Rv1266c | pknH | 1e-38 | 38.92% (185) | transmembrane serine/threonine-protein kinase H |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0361 | - | 2e-08 | 24.12% (170) | hypothetical protein MAB_0361 |
| M. marinum M | MMAR_4171 | - | 4e-39 | 40.00% (185) | transmembrane serine/threonine-protein kinase |
| M. avium 104 | MAV_1417 | - | 7e-41 | 43.01% (186) | serine/threonine-protein kinase PknE |
| M. smegmatis MC2 155 | MSMEG_4554 | - | 5e-45 | 40.74% (216) | serine/threonine-protein kinase PknH, putative |
| M. thermoresistible (build 8) | TH_3756 | - | 3e-21 | 31.89% (185) | PUTATIVE putative conserved lipoprotein LppH |
| M. ulcerans Agy99 | MUL_4150 | lppH | 2e-28 | 33.03% (218) | lipoprotein LppH |
| M. vanbaalenii PYR-1 | Mvan_3878 | - | 6e-79 | 64.45% (211) | hypothetical protein Mvan_3878 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2675|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3878|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4554|M.smegmatis_MC2_155 --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 MSDAQDSRVGSMFGPYHLKRLLGRGGMGEVYEAEHTVKEWTVAVKLMTAE
Rv1266c|M.tuberculosis_H37Rv MSDAQDSRVGSMFGPYHLKRLLGRGGMGEVYEAEHTVKEWTVAVKLMTAE
MMAR_4171|M.marinum_M MSDAQGSRVGSTFGPYRLTRLLGRGGMGEVYEAEHTVKEWTVAVKLMSET
MAV_1417|M.avium_104 MSDERSSKVGSMFGPYHLKRLLGRGGMGEVYEAEHTVKEWTVAVKLLNES
TH_3756|M.thermoresistible__bu --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
MAB_0361|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_2675|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3878|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4554|M.smegmatis_MC2_155 --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 FSKDPVFRERMKREARIAGRLQEPHVVPIHDYGEVDGQMFLEMRLVEGTD
Rv1266c|M.tuberculosis_H37Rv FSKDPVFRERMKREARIAGRLQEPHVVPIHDYGEVDGQMFLEMRLVEGTD
MMAR_4171|M.marinum_M FSKDPVFRERMKREARITGRLQEPHVVPIHDYGEIDGQMYLEMRLIEGTD
MAV_1417|M.avium_104 FSSDPVFRERMKREARTAGRLQEPHVVPVHDYGEIDGQMFLEMRLVEGTD
TH_3756|M.thermoresistible__bu --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
MAB_0361|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_2675|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3878|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4554|M.smegmatis_MC2_155 --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 LDSVLKRFGPLTPPRAVAIITQIASALDAAHADGVMHRDVKPQNILITRD
Rv1266c|M.tuberculosis_H37Rv LDSVLKRFGPLTPPRAVAIITQIASALDAAHADGVMHRDVKPQNILITRD
MMAR_4171|M.marinum_M LDNLLKRFGPLTPPRAVAIITQVASALDAAHAAGVMHRDVKPQNILVTRE
MAV_1417|M.avium_104 LDSVLKRFGPLPPPRAVAIITQIASALDAAHAAGVMHRDVKPQNILVTRD
TH_3756|M.thermoresistible__bu --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
MAB_0361|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_2675|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3878|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4554|M.smegmatis_MC2_155 --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 DFAYLVDFGIASATTDEKLTQLGTAVGTWKYMAPERFSNDEVTYRADIYA
Rv1266c|M.tuberculosis_H37Rv DFAYLVDFGIASATTDEKLTQLGTAVGTWKYMAPERFSNDEVTYRADIYA
MMAR_4171|M.marinum_M DFAYLVDFGIASATTDEKLTQLGTAVGTWKYMAPERFSNDEVTYRADIYA
MAV_1417|M.avium_104 DFAYLVDFGIASATTDEKLTQLGTAVGTWKYMAPERFSDAEVTYRADIYA
TH_3756|M.thermoresistible__bu --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
MAB_0361|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_2675|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3878|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4554|M.smegmatis_MC2_155 --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 LACVLHECLTGAPPYRADSAGTLVSSHLMGPIPQPSAIRPGIPKAFDAVV
Rv1266c|M.tuberculosis_H37Rv LACVLHECLTGAPPYRADSAGTLVSSHLMGPIPQPSAIRPGIPKAFDAVV
MMAR_4171|M.marinum_M LACVLHECLTGSPPYRADSASMLVTAHMMDPIPQPSTVRAGIPKAFDTVI
MAV_1417|M.avium_104 LACVLFECLTGSAPYRADSAGVLVSAHVMDPIPAPSARRPGVPKAFDAVI
TH_3756|M.thermoresistible__bu --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
MAB_0361|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_2675|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3878|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4554|M.smegmatis_MC2_155 --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 ARGMAKKPEDRYASAGDLALAAHEALSDPDQDHAADILRRSQESTLPG--
Rv1266c|M.tuberculosis_H37Rv ARGMAKKPEDRYASAGDLALAAHEALSDPDQDHAADILRRSQESTLPAPP
MMAR_4171|M.marinum_M ARGMAKQPGDRYASAGDLALAAHEALSNPDQDHAADILRRSQEATLPGPP
MAV_1417|M.avium_104 ARGMAKKPEDRYASAGDLALAAKEALSTPDQDRAATILRRSQEAALPAAG
TH_3756|M.thermoresistible__bu --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
MAB_0361|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_2675|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3878|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4554|M.smegmatis_MC2_155 --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 ---------TAAVTAQPPTMPTVTPPPIQAAP------------------
Rv1266c|M.tuberculosis_H37Rv KPVPPPTMPATAMAPRQPPAPPVTPPGVQPAPKPSYTPPAQPGPAG----
MMAR_4171|M.marinum_M DPAAPPTMPATAAAPPARPGPAATPPRPAPTPQQPPYYPAAAAPAAGSPP
MAV_1417|M.avium_104 QR-------DAGASTVLAPPPAVNTRQPGSAAS-----------------
TH_3756|M.thermoresistible__bu --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
MAB_0361|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_2675|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3878|M.vanbaalenii_PYR-1 -----------------------------------------------MAD
MSMEG_4554|M.smegmatis_MC2_155 --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 ------------------------------TGQPSWAPNSGPMPASGPTP
Rv1266c|M.tuberculosis_H37Rv -------------------------QRPGPTGQPSWAPNSGPMPASGPTP
MMAR_4171|M.marinum_M SGPSAVAGPPRGVAPSGPAGPSGPIPRPPAAGQPGWQQASGPIPASQPTP
MAV_1417|M.avium_104 ------------------------------QAGRGWTPESGPIPAAG-QP
TH_3756|M.thermoresistible__bu --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
MAB_0361|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_2675|M.gilvum_PYR-GCK -------------------------------------------MTALMLP
Mvan_3878|M.vanbaalenii_PYR-1 NGLVNNVGAVRCAYAAG-------------------------AGLAASVL
MSMEG_4554|M.smegmatis_MC2_155 ---MTPGRRWTRLCTAG-------------------------AAAAVMCL
Mb1297c|M.bovis_AF2122/97 TPQYYQGGGWG-APPSG---GPSPWAQTP-----RKTNPWPLVAGAAAVV
Rv1266c|M.tuberculosis_H37Rv TPQYYQGGGWG-APPSG---GPSPWAQTP-----RKTNPWPLVAGAAAVV
MMAR_4171|M.marinum_M SPPYYQGAGWGGAPPPGQPAGPSTWNQGPQGPGPRGRNPWPIVA-AVAIV
MAV_1417|M.avium_104 GPPYYQGGNANWAAAPAQFAGPPPWGRPP-----PKRRVWPIVA-AVVAV
TH_3756|M.thermoresistible__bu ----------------------------------------------MGVL
MUL_4150|M.ulcerans_Agy99 ----MRQRVAALAALVG----------------------------GAGML
MAB_0361|M.abscessus_ATCC_1997 ----------------------------------------------MTIV
Mflv_2675|M.gilvum_PYR-GCK MTACVETVDGTALRGHGAGLTD-VAPLDESRLDSVLVGIDEINSIMGATG
Mvan_3878|M.vanbaalenii_PYR-1 LCACVSTVEGAAVRHPGAATLD-VPPLDEAALDRVLLSVDELNSIMGSIR
MSMEG_4554|M.smegmatis_MC2_155 LSGCVTVVGGTATRDP-AAPPP-GAAVTEVDLDNLLLPVTELGDIVGSDD
Mb1297c|M.bovis_AF2122/97 LVLVLGAIGIWIANRP-KPVQP-PQPVAEERLSALLLNSSEVNAVMGSSS
Rv1266c|M.tuberculosis_H37Rv LVLVLGAIGIWIAIRP-KPVQP-PQPVAEERLSALLLNSSEVNAVMGSSS
MMAR_4171|M.marinum_M LVLIVGGIGVWMITQPPKPSPP-PKPIAEDRLSSLLLSPAEVNSVMGASN
MAV_1417|M.avium_104 LVVIAGGVGVWLVIRP-KPEPPQAAPLTSDRLGALLLSASEVNAVMGSST
TH_3756|M.thermoresistible__bu VAGCGSTGHAESTTAPSTTKTLIPRPLVERELPGLLLSPEQVNAAMGTTD
MUL_4150|M.ulcerans_Agy99 VTGCTNIVDGN-AVAADMSGPLNQTPIAVSALDDLLLDVSQIDSALGATS
MAB_0361|M.abscessus_ATCC_1997 LSAALACAAPALAEQG--------SPIPPAAIDDLMVTPDEASSVMKTG-
: .: : ::: : . : :
Mflv_2675|M.gilvum_PYR-GCK MEVTGELDEMSDHSADVSDPDCLGAVYGAEAPVYEGTDWTAVRD---QVA
Mvan_3878|M.vanbaalenii_PYR-1 MKVSSELDEMTDHTAEVSNPDCLGTVYAAEEPAYAGTGWTAVRD---QVA
MSMEG_4554|M.smegmatis_MC2_155 LTVTVELDQFNDSSAAMDDPDCLAAAFGAQERVYAGTGWTAVRD---QIV
Mb1297c|M.bovis_AF2122/97 MQPGKPITSMDSSPVTVSLPDCQGALYTSQDPVYAGTGYTAING---LIS
Rv1266c|M.tuberculosis_H37Rv MQPGKPITSMDSSPVTVSLPDCQGALYTSQDPVYAGTGYTAING---LIS
MMAR_4171|M.marinum_M IQPGKPITSMDASPVTLSLPECQGALYTSQDPVYSGTGYTAISG---LVA
MAV_1417|M.avium_104 MEPGKPITATDSSSVTVSVPDCQGALYTTQDPVYAGSGYSAVNG---LVS
TH_3756|M.thermoresistible__bu MAIISSQTSLSDHSNTMAPPECLALDGAGEADVYADSGYRAAR----DHS
MUL_4150|M.ulcerans_Agy99 MKVWFNAKAMWDWSKNISDKNCLAVDGPAQDEVYAGTGWTAMRGQRMDDS
MAB_0361|M.abscessus_ATCC_1997 FPVVDRFNALS--ALTTDRPDCGSVVLPS-VATYDRGPYMAAHQ----QY
: . :* . .* : *
Mflv_2675|M.gilvum_PYR-GCK REPGAGNDHWVEQAVVLYPEERNARDFLESSQAVWRDCAN---NALGVG-
Mvan_3878|M.vanbaalenii_PYR-1 REPDGDNDHWVEQTAVIYPAARNAQDFFDRSSVTWQDCAN---ATITTGD
MSMEG_4554|M.smegmatis_MC2_155 REPGSFSPHWIEQVVVLFTSDLHARDFFDQSRETWRGCVG-TLTTYDIDQ
Mb1297c|M.bovis_AF2122/97 SEPGDNYEHWVNQAVVAFPTADKARAFVQTSADKWKNCAG-KTVTVTNKA
Rv1266c|M.tuberculosis_H37Rv SEPGDNYEHWVNQAVVAFPTADKARAFVQTSADKWKNCAG-KTVTVTNKA
MMAR_4171|M.marinum_M SEPGDNNDHWVNQAVVSFPSAAKASSFVETMAGKWKNCAG-KTVTVTNKS
MAV_1417|M.avium_104 SEPGDNYDHWVNQAVVLFPSADKAKSFLQTSLQKWKGCAG-QTVTVTNKS
TH_3756|M.thermoresistible__bu LNNGDNFTHYAKQAVVLFPLAETARAFFEASAEQWPACHEYRHT-----Q
MUL_4150|M.ulcerans_Agy99 VDDSKRRKHYAIQAVVAFPSAHDASAFYNSSVRSWGNCSNRRFTDVSTDQ
MAB_0361|M.abscessus_ATCC_1997 LQDSAPWNVQLAQSIAVFPTDDEARDFASTEMDMWLKCSK----HTVHDS
: . * . :. * * . * *
Mflv_2675|M.gilvum_PYR-GCK -DYLWELGAVEAADLMLTQVTTQ--EGADGWSCQHALSLVSNVTVEAWAC
Mvan_3878|M.vanbaalenii_PYR-1 GDYLWELDAAQVDDTVLTQRVTQ--DGADGWACQHALSVVSNLTVEAWAC
MSMEG_4554|M.smegmatis_MC2_155 MPLEWVVGEVTAEESTISQLSVP--ETAVRGGCHHALSVAANLVAEAWAC
Mb1297c|M.bovis_AF2122/97 KTYRWTFADVKGSPPTITVIDTQ--EGAEGWECQRAMSVANNVVVDVNAC
Rv1266c|M.tuberculosis_H37Rv KTYRWTFADVKGSPPTITVIDTQ--EGAEGWECQRAMSVANNVVVDVNAC
MMAR_4171|M.marinum_M KTYRWTFAQVVGSPPRITMLETQ--EGAEGWECQRAMSVANNVIVDINSC
MAV_1417|M.avium_104 KTYRWTFAQVQGAPPKITLMDTQ--EGADGWECQRALSVANNVIVDINAC
TH_3756|M.thermoresistible__bu SGTKWYVAELTRDGDILKAITVQRDAGHPGWGCGRALVLRNNIIGDVNTC
MUL_4150|M.ulcerans_Agy99 PDTIWTVSDVVNDNGMLSTSQVQ-EAGD-GWTCQRALTVRNNVAIDVVTC
MAB_0361|M.abscessus_ATCC_1997 AQWRYAIGSLHRDDDAVVGSYVMITNDGARMSCSRLLARVRNTATDLRAC
: . : . * : : * : :*
Mflv_2675|M.gilvum_PYR-GCK G--YDITDEAARIADAMIRNAAG----
Mvan_3878|M.vanbaalenii_PYR-1 G--YSISDEAAEIAVAMIENAATK---
MSMEG_4554|M.smegmatis_MC2_155 G--EGVEDQASEIVDQIVANIE-----
Mb1297c|M.bovis_AF2122/97 G--YQITNQAGQIAAKIVDKVNKE---
Rv1266c|M.tuberculosis_H37Rv G--YRITNQAGQIAAKIVDKVNKE---
MMAR_4171|M.marinum_M G--YHITDQGGALADKIVDKIHKETKY
MAV_1417|M.avium_104 G--YRITDQGDQIADKIVAKIDNE---
TH_3756|M.thermoresistible__bu S--ADPGDSAVRIAQQIGENVDAVW--
MUL_4150|M.ulcerans_Agy99 AY-SQSGSVAADVAQQIAAKAAKQ---
MAB_0361|M.abscessus_ATCC_1997 SAGPESYQRLLGIAKIIGPRYDAA---
. . :. : .