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VTTPKPEPEPNAIHAGQLGRILGLGAGSGDVSISTVLGVEYLGKTAEFFGLSNWSSDRPDCGGVLLPSLP QGYDNSGFIDTRTHVHDGAKPGETDSRMMAEQQATTFYTTTAAADFVTMAVTKWGKCANQVVTVNKPKSS ENPREPYIVGEPAMVDGILTVTATRQGPPEDPWQCQHSLTSRRNVVIDVAICAPTGSTQAPLLARWSADR VPQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4596 | - | - | 100% (213) | hypothetical protein MSMEG_4596 |
| M. smegmatis MC2 155 | MSMEG_4595 | - | 2e-11 | 25.24% (206) | serine/threonine-protein kinase PknH, putative |
| M. smegmatis MC2 155 | MSMEG_4598 | lppH | 1e-10 | 25.93% (216) | putative lipoprotein lpph |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1297c | pknH | 6e-12 | 26.19% (210) | transmembrane serine/threonine-protein kinase H |
| M. gilvum PYR-GCK | Mflv_2675 | - | 6e-08 | 24.71% (174) | hypothetical protein Mflv_2675 |
| M. tuberculosis H37Rv | Rv1266c | pknH | 6e-12 | 26.19% (210) | transmembrane serine/threonine-protein kinase H |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0358 | - | 1e-09 | 27.75% (173) | membrane protein PknM or lipoprotein LppH |
| M. marinum M | MMAR_4171 | - | 1e-13 | 24.76% (210) | transmembrane serine/threonine-protein kinase |
| M. avium 104 | MAV_1417 | - | 9e-12 | 27.69% (195) | serine/threonine-protein kinase PknE |
| M. thermoresistible (build 8) | TH_3555 | - | 2e-05 | 20.15% (134) | PUTATIVE - |
| M. ulcerans Agy99 | MUL_4150 | lppH | 3e-10 | 26.98% (189) | lipoprotein LppH |
| M. vanbaalenii PYR-1 | Mvan_3880 | - | 6e-10 | 23.71% (194) | hypothetical protein Mvan_3880 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1297c|M.bovis_AF2122/97 MSDAQDSRVGSMFGPYHLKRLLGRGGMGEVYEAEHTVKEWTVAVKLMTAE
Rv1266c|M.tuberculosis_H37Rv MSDAQDSRVGSMFGPYHLKRLLGRGGMGEVYEAEHTVKEWTVAVKLMTAE
MMAR_4171|M.marinum_M MSDAQGSRVGSTFGPYRLTRLLGRGGMGEVYEAEHTVKEWTVAVKLMSET
MAV_1417|M.avium_104 MSDERSSKVGSMFGPYHLKRLLGRGGMGEVYEAEHTVKEWTVAVKLLNES
Mflv_2675|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3880|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
TH_3555|M.thermoresistible__bu --------------------------------------------------
MSMEG_4596|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0358|M.abscessus_ATCC_1997 --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 FSKDPVFRERMKREARIAGRLQEPHVVPIHDYGEVDGQMFLEMRLVEGTD
Rv1266c|M.tuberculosis_H37Rv FSKDPVFRERMKREARIAGRLQEPHVVPIHDYGEVDGQMFLEMRLVEGTD
MMAR_4171|M.marinum_M FSKDPVFRERMKREARITGRLQEPHVVPIHDYGEIDGQMYLEMRLIEGTD
MAV_1417|M.avium_104 FSSDPVFRERMKREARTAGRLQEPHVVPVHDYGEIDGQMFLEMRLVEGTD
Mflv_2675|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3880|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
TH_3555|M.thermoresistible__bu --------------------------------------------------
MSMEG_4596|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0358|M.abscessus_ATCC_1997 --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 LDSVLKRFGPLTPPRAVAIITQIASALDAAHADGVMHRDVKPQNILITRD
Rv1266c|M.tuberculosis_H37Rv LDSVLKRFGPLTPPRAVAIITQIASALDAAHADGVMHRDVKPQNILITRD
MMAR_4171|M.marinum_M LDNLLKRFGPLTPPRAVAIITQVASALDAAHAAGVMHRDVKPQNILVTRE
MAV_1417|M.avium_104 LDSVLKRFGPLPPPRAVAIITQIASALDAAHAAGVMHRDVKPQNILVTRD
Mflv_2675|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3880|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
TH_3555|M.thermoresistible__bu --------------------------------------------------
MSMEG_4596|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0358|M.abscessus_ATCC_1997 --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 DFAYLVDFGIASATTDEKLTQLGTAVGTWKYMAPERFSNDEVTYRADIYA
Rv1266c|M.tuberculosis_H37Rv DFAYLVDFGIASATTDEKLTQLGTAVGTWKYMAPERFSNDEVTYRADIYA
MMAR_4171|M.marinum_M DFAYLVDFGIASATTDEKLTQLGTAVGTWKYMAPERFSNDEVTYRADIYA
MAV_1417|M.avium_104 DFAYLVDFGIASATTDEKLTQLGTAVGTWKYMAPERFSDAEVTYRADIYA
Mflv_2675|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3880|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
TH_3555|M.thermoresistible__bu --------------------------------------------------
MSMEG_4596|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0358|M.abscessus_ATCC_1997 --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 LACVLHECLTGAPPYRADSAGTLVSSHLMGPIPQPSAIRPGIPKAFDAVV
Rv1266c|M.tuberculosis_H37Rv LACVLHECLTGAPPYRADSAGTLVSSHLMGPIPQPSAIRPGIPKAFDAVV
MMAR_4171|M.marinum_M LACVLHECLTGSPPYRADSASMLVTAHMMDPIPQPSTVRAGIPKAFDTVI
MAV_1417|M.avium_104 LACVLFECLTGSAPYRADSAGVLVSAHVMDPIPAPSARRPGVPKAFDAVI
Mflv_2675|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3880|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
TH_3555|M.thermoresistible__bu --------------------------------------------------
MSMEG_4596|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0358|M.abscessus_ATCC_1997 --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 ARGMAKKPEDRYASAGDLALAAHEALSDPDQDHAADILRRSQESTLPG--
Rv1266c|M.tuberculosis_H37Rv ARGMAKKPEDRYASAGDLALAAHEALSDPDQDHAADILRRSQESTLPAPP
MMAR_4171|M.marinum_M ARGMAKQPGDRYASAGDLALAAHEALSNPDQDHAADILRRSQEATLPGPP
MAV_1417|M.avium_104 ARGMAKKPEDRYASAGDLALAAKEALSTPDQDRAATILRRSQEAALPAAG
Mflv_2675|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3880|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
TH_3555|M.thermoresistible__bu --------------------------------------------------
MSMEG_4596|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0358|M.abscessus_ATCC_1997 --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 ---------TAAVTAQPPTMPTVTPPPIQAAP------------------
Rv1266c|M.tuberculosis_H37Rv KPVPPPTMPATAMAPRQPPAPPVTPPGVQPAPKPSYTPPAQPGPAG----
MMAR_4171|M.marinum_M DPAAPPTMPATAAAPPARPGPAATPPRPAPTPQQPPYYPAAAAPAAGSPP
MAV_1417|M.avium_104 QR-------DAGASTVLAPPPAVNTRQPGSAAS-----------------
Mflv_2675|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3880|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
TH_3555|M.thermoresistible__bu --------------------------------------------------
MSMEG_4596|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0358|M.abscessus_ATCC_1997 --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 ------------------------------TGQPSWAPNSGPMPASGPTP
Rv1266c|M.tuberculosis_H37Rv -------------------------QRPGPTGQPSWAPNSGPMPASGPTP
MMAR_4171|M.marinum_M SGPSAVAGPPRGVAPSGPAGPSGPIPRPPAAGQPGWQQASGPIPASQPTP
MAV_1417|M.avium_104 ------------------------------QAGRGWTPESGPIPAAG-QP
Mflv_2675|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3880|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
TH_3555|M.thermoresistible__bu --------------------------------------------------
MSMEG_4596|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0358|M.abscessus_ATCC_1997 --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 TPQYYQGGGWG-APPSG---GPSPWAQTP-----RKTNPWPLVAGAAAVV
Rv1266c|M.tuberculosis_H37Rv TPQYYQGGGWG-APPSG---GPSPWAQTP-----RKTNPWPLVAGAAAVV
MMAR_4171|M.marinum_M SPPYYQGAGWGGAPPPGQPAGPSTWNQGPQGPGPRGRNPWPIVA-AVAIV
MAV_1417|M.avium_104 GPPYYQGGNANWAAAPAQFAGPPPWGRPP-----PKRRVWPIVA-AVVAV
Mflv_2675|M.gilvum_PYR-GCK --------------------------------------------MTALML
Mvan_3880|M.vanbaalenii_PYR-1 ----------------------------------------MALAGLAVSL
MUL_4150|M.ulcerans_Agy99 ---------------------------------MRQRVAALAALVGGAGM
TH_3555|M.thermoresistible__bu -------------------------------MTKLTRRILGGCAAAVVVL
MSMEG_4596|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0358|M.abscessus_ATCC_1997 ------------------------------------------------MG
Mb1297c|M.bovis_AF2122/97 LVLVLGAIGIWIANRP-KPVQP-PQPVAEERLSALLLNSSEVNAVMGSSS
Rv1266c|M.tuberculosis_H37Rv LVLVLGAIGIWIAIRP-KPVQP-PQPVAEERLSALLLNSSEVNAVMGSSS
MMAR_4171|M.marinum_M LVLIVGGIGVWMITQPPKPSPP-PKPIAEDRLSSLLLSPAEVNSVMGASN
MAV_1417|M.avium_104 LVVIAGGVGVWLVIRP-KPEPPQAAPLTSDRLGALLLSASEVNAVMGSST
Mflv_2675|M.gilvum_PYR-GCK PMTACVETVDGTALRGHGAGLTDVAPLDESRLDSVLVGIDEINSIMGATG
Mvan_3880|M.vanbaalenii_PYR-1 WATACTSTVDGTAVRPDAAPSAVAGVLTERDLDAVLLDSAEIAALLNSPD
MUL_4150|M.ulcerans_Agy99 LVTGCTNIVDGNAVAADMSGPLNQTPIAVSALDDLLLDVSQIDSALGATS
TH_3555|M.thermoresistible__bu TGAACTHSVEGSAVYAPEVPRDDLPLVKIAELRDLIPTADEARTVVEAPN
MSMEG_4596|M.smegmatis_MC2_155 -MTTPKPEPEPNAIHAGQLGRILGLGAGSGDVS--------ISTVLGVEY
MAB_0358|M.abscessus_ATCC_1997 VASYLCVLAMTVASAGTASANPDELPVQTEALSSLMLEPGDVAPVMGAG-
: . :
Mb1297c|M.bovis_AF2122/97 MQPGKPITSMDSSP-VTVSLPDCQGALYTSQDPVYAGTGYTAINGLISSE
Rv1266c|M.tuberculosis_H37Rv MQPGKPITSMDSSP-VTVSLPDCQGALYTSQDPVYAGTGYTAINGLISSE
MMAR_4171|M.marinum_M IQPGKPITSMDASP-VTLSLPECQGALYTSQDPVYSGTGYTAISGLVASE
MAV_1417|M.avium_104 MEPGKPITATDSSS-VTVSVPDCQGALYTTQDPVYAGSGYSAVNGLVSSE
Mflv_2675|M.gilvum_PYR-GCK MEVTGELDEMSDHS-ADVSDPDCLGAVYGAEAPVYEGTDWTAVRDQVARE
Mvan_3880|M.vanbaalenii_PYR-1 IEVTDEIDEMTDTS-ADVSNPECLGALYTAEDPVYESTGYTAVLTRLASE
MUL_4150|M.ulcerans_Agy99 MKVWFNAKAMWDWS-KNISDKNCLAVDGPAQDEVYAGTGWTAMRGQRMDD
TH_3555|M.thermoresistible__bu LIYLLAYTKPDSLPPDMLSEPECASAVIPNDASAYRGSGYAAVYGRLADD
MSMEG_4596|M.smegmatis_MC2_155 LGKTAEFFGLSNWS---SDRPDCGGVLLPSLPQGYDNSGFIDTRTHVHDG
MAB_0358|M.abscessus_ATCC_1997 MYVAGDWAALVSDR---TDRPECGSVVLASG-ASYESSNYLSGRYRSLID
: . :* .. * .:.:
Mb1297c|M.bovis_AF2122/97 PGDNYE---HWVNQAVVAFPTADKARAFVQTSADKWKNCAG-KTVTVTNK
Rv1266c|M.tuberculosis_H37Rv PGDNYE---HWVNQAVVAFPTADKARAFVQTSADKWKNCAG-KTVTVTNK
MMAR_4171|M.marinum_M PGDNND---HWVNQAVVSFPSAAKASSFVETMAGKWKNCAG-KTVTVTNK
MAV_1417|M.avium_104 PGDNYD---HWVNQAVVLFPSADKAKSFLQTSLQKWKGCAG-QTVTVTNK
Mflv_2675|M.gilvum_PYR-GCK PGAGND---HWVEQAVVLYPEERNARDFLESSQAVWRDCAN-NALGVGD-
Mvan_3880|M.vanbaalenii_PYR-1 PGDDNE---HWVEESAVLVPTAEDAEQFVERSAREWDDCAG-RQVSISDG
MUL_4150|M.ulcerans_Agy99 SVDDSKRRKHYAIQAVVAFPSAHDASAFYNSSVRSWGNCSNRRFTDVSTD
TH_3555|M.thermoresistible__bu LR------SHRISTGVAAFAGAQEAHEWVTQQVDRWRDCTD-RTLTISLN
MSMEG_4596|M.smegmatis_MC2_155 AKPGETDSRMMAEQQATTFYTTTAAADFVTMAVTKWGKCAN-QVVTVNKP
MAB_0358|M.abscessus_ATCC_1997 SPNWTR----LVDQSMVIFPEWSDATDFALAEADRWRACENQRVTSLLPQ
. * : * * . . :
Mb1297c|M.bovis_AF2122/97 AKTYRWTFADVKGSPPTIT------VIDTQEGAEGWECQRAMSVANNVVV
Rv1266c|M.tuberculosis_H37Rv AKTYRWTFADVKGSPPTIT------VIDTQEGAEGWECQRAMSVANNVVV
MMAR_4171|M.marinum_M SKTYRWTFAQVVGSPPRIT------MLETQEGAEGWECQRAMSVANNVIV
MAV_1417|M.avium_104 SKTYRWTFAQVQGAPPKIT------LMDTQEGADGWECQRALSVANNVIV
Mflv_2675|M.gilvum_PYR-GCK ---YLWELGAVEAADLMLT------QVTTQEGADGWSCQHALSLVSNVTV
Mvan_3880|M.vanbaalenii_PYR-1 EEWFDWELDAVVRDGGMVS------QQSTILDSIDWQCQHTVVSVSNLII
MUL_4150|M.ulcerans_Agy99 QPDTIWTVSDVVNDNGMLS------TSQVQEAGDGWTCQRALTVRNNVAI
TH_3555|M.thermoresistible__bu GQELQWKTSGPTRAEGVHV------LLRRQEGTD-YACSRGVAARSNVAA
MSMEG_4596|M.smegmatis_MC2_155 KSSENPREPYIVGEPAMVDGILTVTATRQGPPEDPWQCQHSLTSRRNVVI
MAB_0358|M.abscessus_ATCC_1997 PDGSTRREWVQLRKIVQVQEVLVVGYTWPTDFGGVIYCQHALAPLRNVAI
*.: : *:
Mb1297c|M.bovis_AF2122/97 DVNACGYQITN---QAGQIAAKIVDKVNKE---
Rv1266c|M.tuberculosis_H37Rv DVNACGYRITN---QAGQIAAKIVDKVNKE---
MMAR_4171|M.marinum_M DINSCGYHITD---QGGALADKIVDKIHKETKY
MAV_1417|M.avium_104 DINACGYRITD---QGDQIADKIVAKIDNE---
Mflv_2675|M.gilvum_PYR-GCK EAWACGYDITD---EAARIADAMIRNAAG----
Mvan_3880|M.vanbaalenii_PYR-1 EASVCAERIHD---EATTVVAEMIAKASARTR-
MUL_4150|M.ulcerans_Agy99 DVVTCAYSQSGS--VAADVAQQIAAKAAKQ---
TH_3555|M.thermoresistible__bu DVLVCGRNPEAVNPQAGKLANLMLSKIGD----
MSMEG_4596|M.smegmatis_MC2_155 DVAICAPTGST---QAPLLARWSADRVPQ----
MAB_0358|M.abscessus_ATCC_1997 DVRACAERDGS---RALDLILGLLPRVARA---
: *. . : .