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ALAGLAVSLWATACTSTVDGTAVRPDAAPSAVAGVLTERDLDAVLLDSAEIAALLNSPDIEVTDEIDEMT DTSADVSNPECLGALYTAEDPVYESTGYTAVLTRLASEPGDDNEHWVEESAVLVPTAEDAEQFVERSARE WDDCAGRQVSISDGEEWFDWELDAVVRDGGMVSQQSTILDSIDWQCQHTVVSVSNLIIEASVCAERIHDE ATTVVAEMIAKASARTR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3880 | - | - | 100% (228) | hypothetical protein Mvan_3880 |
| M. vanbaalenii PYR-1 | Mvan_3878 | - | 2e-50 | 43.95% (223) | hypothetical protein Mvan_3878 |
| M. vanbaalenii PYR-1 | Mvan_4460 | - | 1e-21 | 28.51% (228) | putative lipoprotein LppH |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1297c | pknH | 2e-34 | 34.00% (200) | transmembrane serine/threonine-protein kinase H |
| M. gilvum PYR-GCK | Mflv_2675 | - | 1e-45 | 44.04% (218) | hypothetical protein Mflv_2675 |
| M. tuberculosis H37Rv | Rv1266c | pknH | 7e-35 | 34.50% (200) | transmembrane serine/threonine-protein kinase H |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0358 | - | 3e-09 | 25.00% (236) | membrane protein PknM or lipoprotein LppH |
| M. marinum M | MMAR_4171 | - | 1e-33 | 33.17% (199) | transmembrane serine/threonine-protein kinase |
| M. avium 104 | MAV_1417 | - | 9e-34 | 33.17% (199) | serine/threonine-protein kinase PknE |
| M. smegmatis MC2 155 | MSMEG_4554 | - | 1e-34 | 33.94% (218) | serine/threonine-protein kinase PknH, putative |
| M. thermoresistible (build 8) | TH_3756 | - | 9e-17 | 27.04% (196) | PUTATIVE putative conserved lipoprotein LppH |
| M. ulcerans Agy99 | MUL_4150 | lppH | 3e-24 | 29.87% (231) | lipoprotein LppH |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_3880|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2675|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_4554|M.smegmatis_MC2_155 --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 MSDAQDSRVGSMFGPYHLKRLLGRGGMGEVYEAEHTVKEWTVAVKLMTAE
Rv1266c|M.tuberculosis_H37Rv MSDAQDSRVGSMFGPYHLKRLLGRGGMGEVYEAEHTVKEWTVAVKLMTAE
MMAR_4171|M.marinum_M MSDAQGSRVGSTFGPYRLTRLLGRGGMGEVYEAEHTVKEWTVAVKLMSET
MAV_1417|M.avium_104 MSDERSSKVGSMFGPYHLKRLLGRGGMGEVYEAEHTVKEWTVAVKLLNES
TH_3756|M.thermoresistible__bu --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
MAB_0358|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_3880|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2675|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_4554|M.smegmatis_MC2_155 --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 FSKDPVFRERMKREARIAGRLQEPHVVPIHDYGEVDGQMFLEMRLVEGTD
Rv1266c|M.tuberculosis_H37Rv FSKDPVFRERMKREARIAGRLQEPHVVPIHDYGEVDGQMFLEMRLVEGTD
MMAR_4171|M.marinum_M FSKDPVFRERMKREARITGRLQEPHVVPIHDYGEIDGQMYLEMRLIEGTD
MAV_1417|M.avium_104 FSSDPVFRERMKREARTAGRLQEPHVVPVHDYGEIDGQMFLEMRLVEGTD
TH_3756|M.thermoresistible__bu --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
MAB_0358|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_3880|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2675|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_4554|M.smegmatis_MC2_155 --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 LDSVLKRFGPLTPPRAVAIITQIASALDAAHADGVMHRDVKPQNILITRD
Rv1266c|M.tuberculosis_H37Rv LDSVLKRFGPLTPPRAVAIITQIASALDAAHADGVMHRDVKPQNILITRD
MMAR_4171|M.marinum_M LDNLLKRFGPLTPPRAVAIITQVASALDAAHAAGVMHRDVKPQNILVTRE
MAV_1417|M.avium_104 LDSVLKRFGPLPPPRAVAIITQIASALDAAHAAGVMHRDVKPQNILVTRD
TH_3756|M.thermoresistible__bu --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
MAB_0358|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_3880|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2675|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_4554|M.smegmatis_MC2_155 --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 DFAYLVDFGIASATTDEKLTQLGTAVGTWKYMAPERFSNDEVTYRADIYA
Rv1266c|M.tuberculosis_H37Rv DFAYLVDFGIASATTDEKLTQLGTAVGTWKYMAPERFSNDEVTYRADIYA
MMAR_4171|M.marinum_M DFAYLVDFGIASATTDEKLTQLGTAVGTWKYMAPERFSNDEVTYRADIYA
MAV_1417|M.avium_104 DFAYLVDFGIASATTDEKLTQLGTAVGTWKYMAPERFSDAEVTYRADIYA
TH_3756|M.thermoresistible__bu --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
MAB_0358|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_3880|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2675|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_4554|M.smegmatis_MC2_155 --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 LACVLHECLTGAPPYRADSAGTLVSSHLMGPIPQPSAIRPGIPKAFDAVV
Rv1266c|M.tuberculosis_H37Rv LACVLHECLTGAPPYRADSAGTLVSSHLMGPIPQPSAIRPGIPKAFDAVV
MMAR_4171|M.marinum_M LACVLHECLTGSPPYRADSASMLVTAHMMDPIPQPSTVRAGIPKAFDTVI
MAV_1417|M.avium_104 LACVLFECLTGSAPYRADSAGVLVSAHVMDPIPAPSARRPGVPKAFDAVI
TH_3756|M.thermoresistible__bu --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
MAB_0358|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_3880|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2675|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_4554|M.smegmatis_MC2_155 --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 ARGMAKKPEDRYASAGDLALAAHEALSDPDQDHAADILRRSQESTLPG--
Rv1266c|M.tuberculosis_H37Rv ARGMAKKPEDRYASAGDLALAAHEALSDPDQDHAADILRRSQESTLPAPP
MMAR_4171|M.marinum_M ARGMAKQPGDRYASAGDLALAAHEALSNPDQDHAADILRRSQEATLPGPP
MAV_1417|M.avium_104 ARGMAKKPEDRYASAGDLALAAKEALSTPDQDRAATILRRSQEAALPAAG
TH_3756|M.thermoresistible__bu --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
MAB_0358|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_3880|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2675|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_4554|M.smegmatis_MC2_155 --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 ---------TAAVTAQPPTMPTVTPPPIQAAP------------------
Rv1266c|M.tuberculosis_H37Rv KPVPPPTMPATAMAPRQPPAPPVTPPGVQPAPKPSYTPPAQPGPAG----
MMAR_4171|M.marinum_M DPAAPPTMPATAAAPPARPGPAATPPRPAPTPQQPPYYPAAAAPAAGSPP
MAV_1417|M.avium_104 QR-------DAGASTVLAPPPAVNTRQPGSAAS-----------------
TH_3756|M.thermoresistible__bu --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
MAB_0358|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_3880|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2675|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_4554|M.smegmatis_MC2_155 --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 ------------------------------TGQPSWAPNSGPMPASGPTP
Rv1266c|M.tuberculosis_H37Rv -------------------------QRPGPTGQPSWAPNSGPMPASGPTP
MMAR_4171|M.marinum_M SGPSAVAGPPRGVAPSGPAGPSGPIPRPPAAGQPGWQQASGPIPASQPTP
MAV_1417|M.avium_104 ------------------------------QAGRGWTPESGPIPAAG-QP
TH_3756|M.thermoresistible__bu --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
MAB_0358|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_3880|M.vanbaalenii_PYR-1 ----------------------------------------MALAGLAVSL
Mflv_2675|M.gilvum_PYR-GCK --------------------------------------------MTALML
MSMEG_4554|M.smegmatis_MC2_155 -----------------------------MTPGRRWTRLCTAGAAAAVMC
Mb1297c|M.bovis_AF2122/97 TPQYYQGGGWG-APPSG---GPSPWAQTP-----RKTNPWPLVAGAAAVV
Rv1266c|M.tuberculosis_H37Rv TPQYYQGGGWG-APPSG---GPSPWAQTP-----RKTNPWPLVAGAAAVV
MMAR_4171|M.marinum_M SPPYYQGAGWGGAPPPGQPAGPSTWNQGPQGPGPRGRNPWPIVA-AVAIV
MAV_1417|M.avium_104 GPPYYQGGNANWAAAPAQFAGPPPWGRPP-----PKRRVWPIVA-AVVAV
TH_3756|M.thermoresistible__bu ----------------------------------------------MGVL
MUL_4150|M.ulcerans_Agy99 --------------------------------MRQRVAALAALVGGAGML
MAB_0358|M.abscessus_ATCC_1997 ------------------------------------------------MG
Mvan_3880|M.vanbaalenii_PYR-1 WATACTSTVDGTAVRPDAAPSAVAGVLTERDLDAVLLDSAEIAALLNSPD
Mflv_2675|M.gilvum_PYR-GCK PMTACVETVDGTALRGHGAGLTDVAPLDESRLDSVLVGIDEINSIMGATG
MSMEG_4554|M.smegmatis_MC2_155 LLSGCVTVVGGTATR-DPAAPPPGAAVTEVDLDNLLLPVTELGDIVGSDD
Mb1297c|M.bovis_AF2122/97 LVLVLGAIGIWIANRP-KPVQP-PQPVAEERLSALLLNSSEVNAVMGSSS
Rv1266c|M.tuberculosis_H37Rv LVLVLGAIGIWIAIRP-KPVQP-PQPVAEERLSALLLNSSEVNAVMGSSS
MMAR_4171|M.marinum_M LVLIVGGIGVWMITQPPKPSPP-PKPIAEDRLSSLLLSPAEVNSVMGASN
MAV_1417|M.avium_104 LVVIAGGVGVWLVIRP-KPEPPQAAPLTSDRLGALLLSASEVNAVMGSST
TH_3756|M.thermoresistible__bu VAGCGSTGHAESTTAPSTTKTLIPRPLVERELPGLLLSPEQVNAAMGTTD
MUL_4150|M.ulcerans_Agy99 VTGCTNIVDGN-AVAADMSGPLNQTPIAVSALDDLLLDVSQIDSALGATS
MAB_0358|M.abscessus_ATCC_1997 VASYLCVLAMTVASAGTASANPDELPVQTEALSSLMLEPGDVAPVMG-AG
. : * ::: :: :.
Mvan_3880|M.vanbaalenii_PYR-1 IEVTDEIDEMTDTSADVSNPECLGALYTAEDPVYESTGYTAVLT---RLA
Mflv_2675|M.gilvum_PYR-GCK MEVTGELDEMSDHSADVSDPDCLGAVYGAEAPVYEGTDWTAVRD---QVA
MSMEG_4554|M.smegmatis_MC2_155 LTVTVELDQFNDSSAAMDDPDCLAAAFGAQERVYAGTGWTAVRD---QIV
Mb1297c|M.bovis_AF2122/97 MQPGKPITSMDSSPVTVSLPDCQGALYTSQDPVYAGTGYTAING---LIS
Rv1266c|M.tuberculosis_H37Rv MQPGKPITSMDSSPVTVSLPDCQGALYTSQDPVYAGTGYTAING---LIS
MMAR_4171|M.marinum_M IQPGKPITSMDASPVTLSLPECQGALYTSQDPVYSGTGYTAISG---LVA
MAV_1417|M.avium_104 MEPGKPITATDSSSVTVSVPDCQGALYTTQDPVYAGSGYSAVNG---LVS
TH_3756|M.thermoresistible__bu MAIISSQTSLSDHSNTMAPPECLALDGAGEADVYADSGYRAAR----DHS
MUL_4150|M.ulcerans_Agy99 MKVWFNAKAMWDWSKNISDKNCLAVDGPAQDEVYAGTGWTAMRGQRMDDS
MAB_0358|M.abscessus_ATCC_1997 MYVAGDWAALVSDRTDR--PECGSVVLASG-ASYESSNYLSGRY----RS
: :* . * .:.: :
Mvan_3880|M.vanbaalenii_PYR-1 SEPGDDNEHWVEESAVLVPTAEDAEQFVERSAREWDDCAG----RQVSIS
Mflv_2675|M.gilvum_PYR-GCK REPGAGNDHWVEQAVVLYPEERNARDFLESSQAVWRDCAN----NALGVG
MSMEG_4554|M.smegmatis_MC2_155 REPGSFSPHWIEQVVVLFTSDLHARDFFDQSRETWRGCVG----TLTTYD
Mb1297c|M.bovis_AF2122/97 SEPGDNYEHWVNQAVVAFPTADKARAFVQTSADKWKNCAG----KTVTVT
Rv1266c|M.tuberculosis_H37Rv SEPGDNYEHWVNQAVVAFPTADKARAFVQTSADKWKNCAG----KTVTVT
MMAR_4171|M.marinum_M SEPGDNNDHWVNQAVVSFPSAAKASSFVETMAGKWKNCAG----KTVTVT
MAV_1417|M.avium_104 SEPGDNYDHWVNQAVVLFPSADKAKSFLQTSLQKWKGCAG----QTVTVT
TH_3756|M.thermoresistible__bu LNNGDNFTHYAKQAVVLFPLAETARAFFEASAEQWPACHEY---RHT---
MUL_4150|M.ulcerans_Agy99 VDDSKRRKHYAIQAVVAFPSAHDASAFYNSSVRSWGNCSNR---RFTDVS
MAB_0358|M.abscessus_ATCC_1997 LIDSPNWTRLVDQSMVIFPEWSDATDFALAEADRWRACENQRVTSLLPQP
. : : * . * * * *
Mvan_3880|M.vanbaalenii_PYR-1 DGEEWFDWELD-AVVRDGGMVSQQSTILDSID--WQCQHTVVSVSNLIIE
Mflv_2675|M.gilvum_PYR-GCK D----YLWELG-AVEAADLMLTQVTTQEGADG--WSCQHALSLVSNVTVE
MSMEG_4554|M.smegmatis_MC2_155 IDQMPLEWVVG-EVTAEESTISQLSVPETAVR--GGCHHALSVAANLVAE
Mb1297c|M.bovis_AF2122/97 NKAKTYRWTFA-DVKGSPPTITVIDTQEGAEG--WECQRAMSVANNVVVD
Rv1266c|M.tuberculosis_H37Rv NKAKTYRWTFA-DVKGSPPTITVIDTQEGAEG--WECQRAMSVANNVVVD
MMAR_4171|M.marinum_M NKSKTYRWTFA-QVVGSPPRITMLETQEGAEG--WECQRAMSVANNVIVD
MAV_1417|M.avium_104 NKSKTYRWTFA-QVQGAPPKITLMDTQEGADG--WECQRALSVANNVIVD
TH_3756|M.thermoresistible__bu --QSGTKWYVA-ELTRDGDILKAITVQRDAGHPGWGCGRALVLRNNIIGD
MUL_4150|M.ulcerans_Agy99 TDQPDTIWTVS-DVVNDNGMLSTSQVQ-EAGD-GWTCQRALTVRNNVAID
MAB_0358|M.abscessus_ATCC_1997 DGSTRREWVQLRKIVQVQEVLVVGYTWPTDFGGVIYCQHALAPLRNVAID
* : : . * ::: *: :
Mvan_3880|M.vanbaalenii_PYR-1 ASVCA-ERIHDEATTVVAEMIAKASARTR-
Mflv_2675|M.gilvum_PYR-GCK AWACG-YDITDEAARIADAMIRNAAG----
MSMEG_4554|M.smegmatis_MC2_155 AWACG-EGVEDQASEIVDQIVANIE-----
Mb1297c|M.bovis_AF2122/97 VNACG-YQITNQAGQIAAKIVDKVNKE---
Rv1266c|M.tuberculosis_H37Rv VNACG-YRITNQAGQIAAKIVDKVNKE---
MMAR_4171|M.marinum_M INSCG-YHITDQGGALADKIVDKIHKETKY
MAV_1417|M.avium_104 INACG-YRITDQGDQIADKIVAKIDNE---
TH_3756|M.thermoresistible__bu VNTCS-ADPGDSAVRIAQQIGENVDAVW--
MUL_4150|M.ulcerans_Agy99 VVTCAYSQSGSVAADVAQQIAAKAAKQ---
MAB_0358|M.abscessus_ATCC_1997 VRACA-ERDGSRALDLILGLLPRVARA---
*. . . : : .