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RRLAATLAAAGMLVAGCGAGNHGAASSSTATGSTASPKTPLARGALPDLMLSPNDIDTALGVTGTTSDPP FTALGEDPVRRTDYTFPAECKYTTHAGLASEYAGSGSTAVYGYHDLAPTPAGANQLESPEVYQFVVLFPS PEQASAFLSASSARWPACANRQDTVPADGTNPELRWKVGPVTNANGMLSSQVTVTVNGNGVNVTMPCQRA LTARNNIVIDVDACRKDVGDLGIDIAKQIAGKVDKQ*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2123 | - | - | 100% (247) | PknM protein |
| M. avium 104 | MAV_1417 | - | 4e-18 | 30.43% (207) | serine/threonine-protein kinase PknE |
| M. avium 104 | MAV_4097 | - | 5e-09 | 26.91% (249) | PknJ protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3607 | lppH | 5e-21 | 34.69% (245) | lipoprotein LppH |
| M. gilvum PYR-GCK | Mflv_2235 | - | 4e-23 | 33.46% (254) | putative lipoprotein LppH |
| M. tuberculosis H37Rv | Rv3576 | lppH | 9e-21 | 34.16% (243) | lipoprotein LppH |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0358 | - | 2e-09 | 28.17% (213) | membrane protein PknM or lipoprotein LppH |
| M. marinum M | MMAR_5074 | lppH | 3e-26 | 36.55% (249) | lipoprotein LppH |
| M. smegmatis MC2 155 | MSMEG_4598 | lppH | 5e-14 | 27.71% (231) | putative lipoprotein lpph |
| M. thermoresistible (build 8) | TH_3756 | - | 2e-26 | 34.75% (236) | PUTATIVE putative conserved lipoprotein LppH |
| M. ulcerans Agy99 | MUL_4150 | lppH | 9e-26 | 36.14% (249) | lipoprotein LppH |
| M. vanbaalenii PYR-1 | Mvan_4738 | - | 2e-29 | 36.86% (255) | putative lipoprotein LppH |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3607|M.bovis_AF2122/97 MGKQLAALAALVG-ACMLAAGCTNVVDGTAVA--------------ADKS
Rv3576|M.tuberculosis_H37Rv MGKQLAALAALVG-ACMLAAGCTNVVDGTAVA--------------ADKS
MMAR_5074|M.marinum_M MRQRVAALAALVGGAGMLVTGCTNIVDGNAVA--------------ADMS
MUL_4150|M.ulcerans_Agy99 MRQRVAALAALVGGAGMLVTGCTNIVDGNAVA--------------ADMS
MAV_2123|M.avium_104 --MRRLAATLAAAG--MLVAGCGAG-NHGAAS-----------SSTATGS
Mvan_4738|M.vanbaalenii_PYR-1 --MREHTAALTVAATCVLVAACGGGGNEGATSTTPSTLLSPTTSAPAPPT
Mflv_2235|M.gilvum_PYR-GCK -----MRRAVAIAGIAIMVTGCAST--SSAES-----------AEPP--T
TH_3756|M.thermoresistible__bu --------------MGVLVAGCGST--GHAES-----------TTAPSTT
MSMEG_4598|M.smegmatis_MC2_155 ---MAVVVAIGAGVTVTVISGGSGKNTSTAES------------------
MAB_0358|M.abscessus_ATCC_1997 --------MGVASYLCVLAMTVASAGTASANP------------------
: * .
Mb3607|M.bovis_AF2122/97 GPLHQDPIPVSALEGLLLDLSQINAALGATSMKVWFNAKAMWDWS-----
Rv3576|M.tuberculosis_H37Rv GPLHQDPIPVSALEGLLLDLSQINAALGATSMKVWFNAKAMWDWS-----
MMAR_5074|M.marinum_M GPLNQTPIAVSALDDLLLDVNQIDSALGATSMKVWFNAKAMWDWS-----
MUL_4150|M.ulcerans_Agy99 GPLNQTPIAVSALDDLLLDVSQIDSALGATSMKVWFNAKAMWDWS-----
MAV_2123|M.avium_104 TASPKTPLARGALPDLMLSPNDIDTALGVTGTTSDPPFTALGEDPVRRTD
Mvan_4738|M.vanbaalenii_PYR-1 TSTPPPPVAESALDGLLLSPAEIDTVVGATGMAVAGTSTSLAEDITVPPD
Mflv_2235|M.gilvum_PYR-GCK RTMIPRPLVEREIGEVLLSPEEIAALMGVPAMTVIEAQTSLSDH----SD
TH_3756|M.thermoresistible__bu KTLIPRPLVERELPGLLLSPEQVNAAMGTTDMAIISSQTSLSDH----SN
MSMEG_4598|M.smegmatis_MC2_155 -QPSAPPVPVGALRGLLLTPAEAAKAVGTNTLSGSEEMGDKIYDKAG--A
MAB_0358|M.abscessus_ATCC_1997 ---DELPVQTEALSSLMLEPGDVAPVMGAG-MYVAGDWAALVSDR-----
*: : ::* : :*.
Mb3607|M.bovis_AF2122/97 KSVADKNCLAIDGPAQEKVYAGTGWTAMRGQRLDDSINDSKKRDHY--AI
Rv3576|M.tuberculosis_H37Rv KSVADKNCLAIDGPAQEKVYAGTGWTAMRGQRLDDSIDDSKKRDHY--AI
MMAR_5074|M.marinum_M KNISDKNCLAVDGPAQDEVYAGTGWTAMRGQRMDDSVDDSKRRKHY--AI
MUL_4150|M.ulcerans_Agy99 KNISDKNCLAVDGPAQDEVYAGTGWTAMRGQRMDDSVDDSKRRKHY--AI
MAV_2123|M.avium_104 YTFP-AECKYTTHAGLASEYAGSGSTAVYGYHDLAPTPAGANQLESPEVY
Mvan_4738|M.vanbaalenii_PYR-1 APEEKKACVGIAGTAEAQAYAGSGSTAVRDQALRAPNDSGATLSAG----
Mflv_2235|M.gilvum_PYR-GCK IMAP-IECLAIDGAGELQVYANSDYRASRDQSLND--GEGWKTYVK----
TH_3756|M.thermoresistible__bu TMAP-PECLALDGAGEADVYADSGYRAARDHSLNN--GDNFTHYAK----
MSMEG_4598|M.smegmatis_MC2_155 GSIVDGDCVSLM-PGTEAKYTGSGYTAVRRQYLVNRPEIDYLT-------
MAB_0358|M.abscessus_ATCC_1997 --TDRPECGSVVLASGAS-YESSNYLSGRYRSLID--SPNWTRLVD----
* .. * .:. : .
Mb3607|M.bovis_AF2122/97 QAVVGFPTAHDAEEFYSSSVQSWSSCS----NRRFVEVTPGQ-DDAAWTV
Rv3576|M.tuberculosis_H37Rv QAVVGFPTAHDAEEFYSSSVQSWSSCS----NRRFVEVTPGQ-DDAAWTV
MMAR_5074|M.marinum_M QAVVAFPSAHDASAFYNSSVRSWGNCS----NRRFTDVSTDQ-PDTIWTV
MUL_4150|M.ulcerans_Agy99 QAVVAFPSAHDASAFYNSSVRSWGNCS----NRRFTDVSTDQ-PDTIWTV
MAV_2123|M.avium_104 QFVVLFPSPEQASAFLSASSARWPACA----NRQDTVPADGTNPELRWKV
Mvan_4738|M.vanbaalenii_PYR-1 QAVVLFPTADEAATFFAESAQKWPLCR----GYN----AGGS----PVTV
Mflv_2235|M.gilvum_PYR-GCK QAVVLFPYLEKAGEFFDASVAQWPACR----EYTHT--QSGS----VWNP
TH_3756|M.thermoresistible__bu QAVVLFPLAETARAFFEASAEQWPACH----EYRHT--QSGT----KWYV
MSMEG_4598|M.smegmatis_MC2_155 QVVIAFPSAELAEKFITSSEEAWRKCSGRTVNVRYTSPDTPPGPPAFEVI
MAB_0358|M.abscessus_ATCC_1997 QSMVIFPEWSDATDFALAEADRWRACENQR-VTSLLPQPDGSTRREWVQL
* :: ** * * . * *
Mb3607|M.bovis_AF2122/97 ADVVNDNGMLSSSQVQEGGDG-----WTCQRALTARNNVTIDIVTCAYSQ
Rv3576|M.tuberculosis_H37Rv ADVVNDNGMLSSSQVQEGGDG-----WTCQRALTARNNVTIDIVTCAYSQ
MMAR_5074|M.marinum_M SDVVNDNGMLSTSQVQEAGDG-----WTCQRALTVRNNVAIDVVTCAYSQ
MUL_4150|M.ulcerans_Agy99 SDVVNDNGMLSTSQVQEAGDG-----WTCQRALTVRNNVAIDVVTCAYSQ
MAV_2123|M.avium_104 GPVTNANGMLSSQVTVTVNGNGVNVTMPCQRALTARNNIVIDVDACR-KD
Mvan_4738|M.vanbaalenii_PYR-1 GDVSSDNGMLVTSITIQSE----DEPTLCERALTMKNNIVIDVSTCG-GS
Mflv_2235|M.gilvum_PYR-GCK GEITSADRTLS-TVAMQRDAA--APGWGCGRALVHRNNVIVDVNTCS-AA
TH_3756|M.thermoresistible__bu AELTRDGDILK-AITVQRDAG--HPGWGCGRALVLRNNIIGDVNTCS-AD
MSMEG_4598|M.smegmatis_MC2_155 GPVSSNDGMITLRRTREGTGD-ADGDWGCSIASTARNNIVIEGEVCS-RT
MAB_0358|M.abscessus_ATCC_1997 RKIVQVQEVLVVGYTWPTDFG---GVIYCQHALAPLRNVAIDVRACA-ER
: : . * * . .*: : .*
Mb3607|M.bovis_AF2122/97 PDLVAIGIANQIAAKVAKQ-
Rv3576|M.tuberculosis_H37Rv PDLVAIGIANQIAAKVAKQ-
MMAR_5074|M.marinum_M SGSVAADVAQQIAAKAAKQ-
MUL_4150|M.ulcerans_Agy99 SGSVAADVAQQIAAKAAKQ-
MAV_2123|M.avium_104 VGDLGIDIAKQIAGKVDKQ-
Mvan_4738|M.vanbaalenii_PYR-1 S-DSAVRIADQIAARVPGE-
Mflv_2235|M.gilvum_PYR-GCK PGDSAVRIAHQIADKVDAQW
TH_3756|M.thermoresistible__bu PGDSAVRIAQQIGENVDAVW
MSMEG_4598|M.smegmatis_MC2_155 KDSAVTELVRATADKVTAHK
MAB_0358|M.abscessus_ATCC_1997 DGSRALDLILGLLPRVARA-
: ..