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TTTDDPTAPVGGRALTAAESTGLERDALGPWGVFAQGLAAAAPSVAVAVVPFALFVAAGKGAAWAAVIGL LIVVLVALTISFQARRTVSSGSLGTYTGNGLGPGFAFAAGFSLLFGYIGFATTGTLGGVLYLDAFLESIG LGSQAIWFKLLLVAVVVGVAVYLPYRGVSVAARYELAFELLAIASILVIIVASYIGYGFRIDWEQWKPQH LGSSATFIAAVTAVGSYAGFESVASLGAEAKNAHRNIARSLLRVVILLGVLYIFATYPQILHFDDIDGDK AVLPQLADSVGVAWVNQVVSGAVAIAFIVFVTAVTTAAARSLFTFAHEGALPRVFTKVHEEHKTPWAGVV FVGIVAYVFSVAATFSSAGRLVFDVYGGYVANWGFLTSYLLVVIATPIWLRKINALTPWHLVVSIAATVG LGYVIVSNFYPVPEFPFNILPFVFGVILLAGLAWYWYLKRTRPEIAQRIGTIQTLSEEEQRRLADEGIVD VLDGEGGGAR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4549 | - | - | 100% (501) | amino acid permease-associated region, putative |
| M. smegmatis MC2 155 | MSMEG_1137 | - | 4e-61 | 29.46% (465) | amino acid permease-associated region |
| M. smegmatis MC2 155 | MSMEG_6735 | - | 7e-20 | 23.73% (472) | amino acid permease, putative |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2347c | rocE | 4e-16 | 23.39% (449) | cationic amino acid transport integral membrane protein RocE |
| M. gilvum PYR-GCK | Mflv_1244 | - | 3e-18 | 25.13% (390) | amino acid permease-associated region |
| M. tuberculosis H37Rv | Rv2320c | rocE | 4e-16 | 23.39% (449) | cationic amino acid transport integral membrane protein RocE |
| M. leprae Br4923 | MLBr_01974 | - | 5e-08 | 20.67% (358) | putative permease |
| M. abscessus ATCC 19977 | MAB_4122 | - | 0.0 | 72.22% (486) | putative amino acid permease |
| M. marinum M | MMAR_3621 | rocE | 9e-17 | 22.76% (457) | cationic amino acid transport integral membrane protein RocE |
| M. avium 104 | MAV_2087 | - | 3e-13 | 21.62% (421) | amino acid transporter |
| M. thermoresistible (build 8) | TH_0471 | - | 2e-12 | 21.23% (438) | POSSIBLE CATIONIC AMINO ACID TRANSPORT INTEGRAL MEMBRANE |
| M. ulcerans Agy99 | MUL_1244 | rocE | 8e-17 | 23.04% (434) | cationic amino acid transport integral membrane protein RocE |
| M. vanbaalenii PYR-1 | Mvan_2919 | - | 1e-25 | 27.09% (358) | amino acid permease-associated region |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2347c|M.bovis_AF2122/97 --------------------------------------------------
Rv2320c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3621|M.marinum_M --------------------------------------------------
MUL_1244|M.ulcerans_Agy99 --------------------------------------------------
MAV_2087|M.avium_104 --------------------------------------------------
TH_0471|M.thermoresistible__bu --------------------------------------------------
MSMEG_4549|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4122|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_2919|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1244|M.gilvum_PYR-GCK --------------------------------------------------
MLBr_01974|M.leprae_Br4923 MFLSADVSCIEIVDINCSELRNDRRIPPQLALFCTNAANKAESAVTSHGQ
Mb2347c|M.bovis_AF2122/97 MPTTSMSLRELMLRRRPVSGAPVAS-------------------------
Rv2320c|M.tuberculosis_H37Rv MPTTSMSLRELMLRRRPVSGAPVAS-------------------------
MMAR_3621|M.marinum_M MPATSIRLREQMLRRRPVGGAPVAE-------------------------
MUL_1244|M.ulcerans_Agy99 MPATSIRLREQMLRRRPAGGAPVAE-------------------------
MAV_2087|M.avium_104 ----------------------MAP-------------------------
TH_0471|M.thermoresistible__bu -------MTDRLRVKSVEQSIADTD-------------------------
MSMEG_4549|M.smegmatis_MC2_155 ------MTTTDDPTAPVGGRALTAA-------------------------
MAB_4122|M.abscessus_ATCC_1997 -------MSSATHQLTVNGRSLRTA-------------------------
Mvan_2919|M.vanbaalenii_PYR-1 ---------------MNPEASETSE-------------------------
Mflv_1244|M.gilvum_PYR-GCK --------MTESAERTAPGQTTPTA-------------------------
MLBr_01974|M.leprae_Br4923 LPIMANRRWAPHTRRQSGRATSTCSSLMRFSASESRAHSRFECYTLVRWS
Mb2347c|M.bovis_AF2122/97 --GASGNLKRSFGTFQLTMFGVGATIGTGIFFV-LAQAVP-EAGPGVIVS
Rv2320c|M.tuberculosis_H37Rv --GASGNLKRSFGTFQLTMFGVGATIGTGIFFV-LAQAVP-EAGPGVIVS
MMAR_3621|M.marinum_M --GAAGSLKRSFGTFELTMFGVGSTVGTGIFFV-LAEAVP-EAGPAVIVS
MUL_1244|M.ulcerans_Agy99 --GAAGSLKRSFGTFELTMFGVGSTVGTGIFFV-LAEAVP-EAGPAVIVS
MAV_2087|M.avium_104 --GTADHLRRGIGTFQLTMFGVGSTIGTGIFFV-MSQAVP-EAGPAVIVS
TH_0471|M.thermoresistible__bu --EPDSRLRKDLSWWDLTVFGVSVVIGAGIFTV-TASTAGNITGPAISVS
MSMEG_4549|M.smegmatis_MC2_155 --ESTGLERDALGPWGVFAQGLAAAAPSVAVAV-VPFALFVAAGKGAAWA
MAB_4122|M.abscessus_ATCC_1997 --DSHGLERDAIGSWGVFAQGLAAAAPSVAVAT-VPFSLFVAAGKGAAWS
Mvan_2919|M.vanbaalenii_PYR-1 --EIDQIPHRRLPFWVALALSVALVGPTLAMSG-NGQGLIGTVGKSIPLV
Mflv_1244|M.gilvum_PYR-GCK --SVQRLKRNAVGTFGVIFMAVATAAPITAMVGNVPIAVGFGNGSHAPAG
MLBr_01974|M.leprae_Br4923 IRGQGGRAISKLGFWSVVMLGINSIIGAGIFMT--PGEVIKIAGPFAPIA
. : .: . *
Mb2347c|M.bovis_AF2122/97 FIIAGIAAGLAAICYAELASAVPISGSAYSYAYTTLGEAVAMVVAACLLL
Rv2320c|M.tuberculosis_H37Rv FIIAGIAAGLAAICYAELASAVPISGSAYSYAYTTLGEAVAMVVAACLLL
MMAR_3621|M.marinum_M FIIAGVAAGLAAICYAELASAVPVSGSSYSYAYATLGEAVAMGVASCLLL
MUL_1244|M.ulcerans_Agy99 FIIAGVAAGLAAICCAELASAVPVSGSSYSYAYATLGEAVAMGVASCLLL
MAV_2087|M.avium_104 FLLAGVAAGLAAVCYAELASAVPVSGSSYSYAYTTLGEVVAMGVAACLLL
TH_0471|M.thermoresistible__bu FIIAAIACGLAALCYAEFASTVPVAGSAYTFSYATFGEFVAWIIGWDLIL
MSMEG_4549|M.smegmatis_MC2_155 AVIGLLIVVLVALTISFQARRTVSSGSLGTYTGNGLGPGFAFAAGFSLLF
MAB_4122|M.abscessus_ATCC_1997 AVIGLVAVVLIATTISFQAKRTVSSGSLGTYAGNGLGPGAAYAAGFSLLI
Mvan_2919|M.vanbaalenii_PYR-1 FLIGLVGVSLVGYSFVRLTRHLNHAGSAYGLVGGTIGPRTGFFSGFAMLG
Mflv_1244|M.gilvum_PYR-GCK YLVATIVLGLFAIGYATMAKHITATGAFYGYISHGLGRVMGMASGLIITL
MLBr_01974|M.leprae_Br4923 YTLAGIFAAVLAIVFATAAKYVKTNGSSYAYTTAAFGHRIGIYVG---VT
:. : : . : *: :* . .
Mb2347c|M.bovis_AF2122/97 EYGVATAAVAVGWSGYVNKLLSNLFGFQMPHVLSAAPWDTHPG----WVN
Rv2320c|M.tuberculosis_H37Rv EYGVATAAVAVGWSGYVNKLLSNLFGFQMPHVLSAAPWDTHPG----WVN
MMAR_3621|M.marinum_M EYGVATAAVAVGWSGYVNKLLHNVFGFQLPQALSEAPWDERPGEAAGYLN
MUL_1244|M.ulcerans_Agy99 EYGVATAAVAVGLSGYVNKLLHNVFGFQLPQALSEAPWDERPGEAAGYLN
MAV_2087|M.avium_104 EYGVATAAVSVNWSGYLNKLLSNVVGFQLPHALSAAPWDAQPG----YVN
TH_0471|M.thermoresistible__bu EFSVAAAVVAKGWSSYLG----EVFEFAG-ATTRLGPITLDWG-------
MSMEG_4549|M.smegmatis_MC2_155 GYIGFATTGTLGGVLYLDAFLESIGLGSQAIWFKLLLVA-----------
MAB_4122|M.abscessus_ATCC_1997 GYITFATTGTLGGVLYFESFLDVIGIHSEANGFKLALVA-----------
Mvan_2919|M.vanbaalenii_PYR-1 AYWGFSIGTLALTAAFVNSFIAALQPGDETPYQAPWLLI-----------
Mflv_1244|M.gilvum_PYR-GCK AYIVFEASLIGIFAFFFQNFLSSQLGITIHWLVPALLML-----------
MLBr_01974|M.leprae_Br4923 HAITASIAWGVLASSFVSTLLRVAFPEKIWADNDELISVKTLTFLVFIAV
:.
Mb2347c|M.bovis_AF2122/97 LPAVILIGLCALLLIRGASESARVNAIMVLIKLGVLGMFMIIAFSAYSAD
Rv2320c|M.tuberculosis_H37Rv LPAVILIGLCALLLIRGASESARVNAIMVLIKLGVLGMFMIIAFSAYSAD
MMAR_3621|M.marinum_M LPAIILIGLCALLLIRGVSESAKVNAIMVLIKLGVLGMFVILALTAYDTN
MUL_1244|M.ulcerans_Agy99 LPAIILIGLCALLLIRGVSESAKVNAIMVLIKLGVLGMFVILALTAYDTN
MAV_2087|M.avium_104 LPAVMLIGMCALLLIRGASESAKVNAIMVMVKLGVLVVFGILAFTAFDMH
TH_0471|M.thermoresistible__bu --ALLIIGFVTVLLATGTKLSANVSLAITVIKVGVVLLVVIVGAFFIKAA
MSMEG_4549|M.smegmatis_MC2_155 ----VVVGVAVYLPYRGVSVAARYELAFELLAIASILVIIVASYIGYGFR
MAB_4122|M.abscessus_ATCC_1997 ----LVVAFAVYLPYRGVSISAKYELIFEIIATALILIIIVASYISYGWR
Mvan_2919|M.vanbaalenii_PYR-1 ----VVIGAVISFLLSGRDIQLLAKILLAIEGIGILAMIVLVVAIFAQGG
Mflv_1244|M.gilvum_PYR-GCK ----VLNSILTYFDVNLTAKVLGVFLITEIFMLALGAVAVAVKGGGPDGF
MLBr_01974|M.leprae_Br4923 LLAINIFGNLVIRWANGISALGKIFALSVFIAGGLWTIITQHVNNYVTSR
: . . . :
Mb2347c|M.bovis_AF2122/97 HLKDFVP---------------------------FGVAGIGSAAGTIFFS
Rv2320c|M.tuberculosis_H37Rv HLKDFVP---------------------------FGVAGIGSAAGTIFFS
MMAR_3621|M.marinum_M HLKDFAP---------------------------FGVAGVGAAAGTIFFS
MUL_1244|M.ulcerans_Agy99 HLKDFAP---------------------------FGVAGVGAAAGTIFFS
MAV_2087|M.avium_104 HLDDFAP---------------------------FGVAGVGTAAGTIFFS
TH_0471|M.thermoresistible__bu NYTPFIPPAEAGGEAGRSLDQSLFSLITGAEGSSYGWYGLLAGASIVFFA
MSMEG_4549|M.smegmatis_MC2_155 IDWEQWKPQH------------------------LGSSATFIAAVTAVGS
MAB_4122|M.abscessus_ATCC_1997 IDTEQWALTN------------------------LGNSTTFIAAVTAVGA
Mvan_2919|M.vanbaalenii_PYR-1 APGTGIDFSVFSFSDG-----------------DVSGSAVLAGVVAAFLS
Mflv_1244|M.gilvum_PYR-GCK AIAETLNPVG------------------AFQPAAIAGASAGLGLFFAFWS
MLBr_01974|M.leprae_Br4923 SAYQPTTYSLLGVTEIG----------------KSTAASMTLATIVALYA
. . :
Mb2347c|M.bovis_AF2122/97 YIGLDAVSTAGDEVKDPQKTMPRALIAALVVVTGVYVLVALAALG----T
Rv2320c|M.tuberculosis_H37Rv YIGLDAVSTAGDEVKDPQKTMPRALIAALVVVTGVYVLVALAALG----T
MMAR_3621|M.marinum_M FIGLDAVSTAGEEVRNPQQSVPRALIAALFVVTGVYVLVAFAALG----T
MUL_1244|M.ulcerans_Agy99 FIGLDAVSTAGEEVRNPQQSVPRALIAALFVVTGVYVLVAFAALG----T
MAV_2087|M.avium_104 YIGLDAVSTAGDEVTNPQKTMPRALIAALLTVTGVYVFVALAALG----T
TH_0471|M.thermoresistible__bu FIGFDIIATTAEETKNPQRDVARGIMATLGIVTVLYVAVSLVLTG----M
MSMEG_4549|M.smegmatis_MC2_155 YAGFESVASLGAEAKNAHRNIARSLLRVVILLGVLYIFATYPQI------
MAB_4122|M.abscessus_ATCC_1997 YAGFESVASLGAESRDAHRTIARSLLRVVLIIGVLYILATYPQI------
Mvan_2919|M.vanbaalenii_PYR-1 WAGFEACASMGEETDDPKRNIPRALGGTLILTGVLFVVVMFAQVVGF--G
Mflv_1244|M.gilvum_PYR-GCK WVGFESTAMYGEESKDPKRIIPRATMIAVLGVGIFYVFVSWMAIAGTGPQ
MLBr_01974|M.leprae_Br4923 FTGFESIANAAEEMNTPDRTLPKAIPLTILTVGVIYILALVVAMLLG---
: *:: : . * ..: :.:. .: .:: .
Mb2347c|M.bovis_AF2122/97 QPWQDFAEQ-ETAGLAIILDNVTHGEWASTILAAGAVVSIFTVTLVTMYG
Rv2320c|M.tuberculosis_H37Rv QPWQDFAEQ-ETAGLAIILDNVTHGEWASTILAAGAVVSIFTVTLVTMYG
MMAR_3621|M.marinum_M QPWQMFAGQ-EEAGLATILDNVTHSAWASTVLAMGAVISIFTVTLVTMYG
MUL_1244|M.ulcerans_Agy99 QPWQMFAGQ-EEAGLATILDNVTHSAWASTVLAMGAVISIFTVTLVTMYG
MAV_2087|M.avium_104 QPWQDFGGQ-QEAGLATILDHVTHGSWASTILAAGAVISIFSVTLVTMYG
TH_0471|M.thermoresistible__bu VHYTELRAAGENANLATAFA-ANGIDWAAKVISIGALAGLTTVVIVLVLG
MSMEG_4549|M.smegmatis_MC2_155 LHFDDIDGD---KAVLPQLADSVGVAWVNQVVSGAVAIAFIVFVTAVTTA
MAB_4122|M.abscessus_ATCC_1997 LQFRNIDGD---SAILPQIATNAGVAWAIYPISLAVTIAFIVFVTAVINS
Mvan_2919|M.vanbaalenii_PYR-1 TDAAGLEAFQSSGNTLGDLGGTYIGQWFSLVIIFTAIVSAFGCHLATSAT
Mflv_1244|M.gilvum_PYR-GCK QAVELAQSADTSSEIFFAPVRDTYGEWAITLFNILLVTGSFACGMAFHNC
MLBr_01974|M.leprae_Br4923 ------SDKIVATNHTVKLAAAVGNNTFRTIIVVGALVSMFGINVAASFG
. . .
Mb2347c|M.bovis_AF2122/97 QTRILFAMGRDGLLP---ARFAKVNPRTMTPVHNTVIVAIFASTLAAFIP
Rv2320c|M.tuberculosis_H37Rv QTRILFAMGRDGLLP---ARFAKVNPRTMTPVHNTVIVAIFASTLAAFIP
MMAR_3621|M.marinum_M QTRILFAMGRDGLLP---ARFAAVHPRFQTPVSNTVVVAIAAAVLAALVP
MUL_1244|M.ulcerans_Agy99 QTRILFAMGRDGLLP---ARFAAVHPRFQTPVSNTVVVAIAAAVLAALVP
MAV_2087|M.avium_104 ITRILFAMGRDGLLP---PRFARVNPRTMTPVNNTVIVAVAAATLAAFIP
TH_0471|M.thermoresistible__bu QTRVLFAMSRDGLLP---RPLSKTGPR-GTPVRITVLVGALVAIAASVFP
MSMEG_4549|M.smegmatis_MC2_155 AARSLFTFAHEGALP---RVFTKVHEEHKTPWAGVVFVGIVAYVFSVAAT
MAB_4122|M.abscessus_ATCC_1997 AARGLFTLAHEGALP---AVLTRVHPTYKTPVAGIFLIGIIATAFSVTAT
Mvan_2919|M.vanbaalenii_PYR-1 SGRMLYAFGRDGFGP---KALAHIHAETGGPRRATWLVVVVALLVDLICG
Mflv_1244|M.gilvum_PYR-GCK ASRYLYALGREGLSTGLQKTLGATHKTHGSPYIASFVQSGIALVLVLAFF
MLBr_01974|M.leprae_Br4923 APRLWTALSDGRILP----TRLSSKNRFGVPIVAFGITAFLTLAFPLSLR
* ::. . * . .
Mb2347c|M.bovis_AF2122/97 LDSLADMVS----------------IGTLTAFSVVAVG-VIVLRVREPDL
Rv2320c|M.tuberculosis_H37Rv LDSLADMVS----------------IGTLTAFSVVAVG-VIVLRVREPDL
MMAR_3621|M.marinum_M LNRLADMVS----------------IGTLTAFIVVSVG-VIILRVREPAL
MUL_1244|M.ulcerans_Agy99 LNRLADMVS----------------IGTLTAFIVVSVG-VIILRVREPAL
MAV_2087|M.avium_104 LQNLADMVS----------------IGTLTAFVVVSVG-VIVLRVREPDL
TH_0471|M.thermoresistible__bu VGNLEEMVN----------------IGTLFAFALVSAG-VIVLRRTRPDL
MSMEG_4549|M.smegmatis_MC2_155 FSSAGRLVFD-------VYGGYVANWGFLTSYLLVVIATPIWLRKINALT
MAB_4122|M.abscessus_ATCC_1997 LSSVGRLVFD-------VYGNYVANWGFLVSYLLVVVATPIWLYRIKALT
Mvan_2919|M.vanbaalenii_PYR-1 ATGWPDMGTGNAAINTYFLFAVAGSVCLMVCYLLVEIAAAYFVGAPKFES
Mflv_1244|M.gilvum_PYR-GCK FAGMDPYIHMYT------LLAILGTMAILIVQSLCAFSVVAYFHFHKNHP
MLBr_01974|M.leprae_Br4923 FDSLNLTGLA--------------VIARFIQFIIVPIALFALARSRTTNS
: : .
Mb2347c|M.bovis_AF2122/97 PRG----FKVPGYPVTPVLSVLACGYILAS-----------LHWYTWLAF
Rv2320c|M.tuberculosis_H37Rv PRG----FKVPGYPVTPVLSVLACGYILAS-----------LHWYTWLAF
MMAR_3621|M.marinum_M PRG----FWVPGYPVTPILSILACGYLLYS-----------LHWYTWIAF
MUL_1244|M.ulcerans_Agy99 PRG----FWVPGYPVTPILSILACGYLLYS-----------LHWYTWIAF
MAV_2087|M.avium_104 PRG----FRVPGYPVTPVLSIMACGYILAS-----------LHWYTWIAF
TH_0471|M.thermoresistible__bu KRG----FRVPFVPWLPLAAIAACLWLMLN-----------LTGLTWVRF
MSMEG_4549|M.smegmatis_MC2_155 PWH----LVVSIAATVGLGYVIVSNFYPVP-----------EFPFNILPF
MAB_4122|M.abscessus_ATCC_1997 PAR----LSVSAAATVAIGYVIFSNFYPIP-----------KFPFNILPL
Mvan_2919|M.vanbaalenii_PYR-1 VHGGTGRVAGLVLPLLGAVVIVTVLWFNVKD----------ADSWSAAPM
Mflv_1244|M.gilvum_PYR-GCK SSAH--WFKTFLAPLTGGIGMLYVVYLLWEHKESAAGAASGTLLFKLTPW
MLBr_01974|M.leprae_Br4923 VYVKR---NVFTDKVLPITAVVVSAGLMVS----------FDYRSIFLTR
:
Mb2347c|M.bovis_AF2122/97 SG--WVAVAVIFYLMWGRHHSALNEEVP----------------------
Rv2320c|M.tuberculosis_H37Rv SG--WVAVAVIFYLMWGRHHSALNEEVP----------------------
MMAR_3621|M.marinum_M GG--WVGIALIFYLFWGRHHSRLNAPALHDNPTGEER-------------
MUL_1244|M.ulcerans_Agy99 GG--WVGIALIFYLFWGRHHSRLNAPALHDNPTGEER-------------
MAV_2087|M.avium_104 SG--WVLLALIFYFVWGRHHSALNDAAVD--PSGQER-------------
TH_0471|M.thermoresistible__bu LG--WMALGLVLYFFYGRHHSMLGRGMTDISARRTG--------------
MSMEG_4549|M.smegmatis_MC2_155 VFGVILLAGLAWYWYLKRTRPEIAQRIGTIQTLSEEEQRRLADEGIVDVL
MAB_4122|M.abscessus_ATCC_1997 IFGAILLAGLLRYWYLRILRPEVAARIGSIQTLSESEKERLAELGILEVL
Mvan_2919|M.vanbaalenii_PYR-1 LGLYWCALGLVIAVALSGIAKRVGESLAIELELVPRPTGAVEPTQPA---
Mflv_1244|M.gilvum_PYR-GCK IVVGVFAFGAAMALYFKFKDKRRYELIGRIVYDDSEVRD-----------
MLBr_01974|M.leprae_Br4923 GGPNYFSISLIAITFIGIPAVAYLHYYRTSGIK-----------------
.
Mb2347c|M.bovis_AF2122/97 --------------------
Rv2320c|M.tuberculosis_H37Rv --------------------
MMAR_3621|M.marinum_M --------------------
MUL_1244|M.ulcerans_Agy99 --------------------
MAV_2087|M.avium_104 --------------------
TH_0471|M.thermoresistible__bu --------------------
MSMEG_4549|M.smegmatis_MC2_155 DGEGGGAR------------
MAB_4122|M.abscessus_ATCC_1997 HEEPAAEPVPEPVDTGVLVK
Mvan_2919|M.vanbaalenii_PYR-1 --------------------
Mflv_1244|M.gilvum_PYR-GCK --------------------
MLBr_01974|M.leprae_Br4923 --------------------