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DDIATRTTADTPTAAGPMRREFSMWSAAMLGFVFVSPIVAMYMVFGLGLAAAGPGFWWALVVVLIGQVLI GVTFGVLASRWPMAGGVYQWSRRLLGSAYGWFAGWAYMWTLLVTLTAVSYGGALFAAAAFDLDAENQKLM TFVGMVILAGAVLINVLGRVAVRIVGFLCLVAEVTGSVGIAIWLLCFHKVNSVSSLGSAVSWPPDTAFMA TPFVLAVMFAGWSFLGFESASTLAEEVGQPKRDIPKAIVGSLIGVGLVVLFTCFAFLMAMPESAVNDADP VAATLTAYLPAPVFKAVMILFVIAYFATVVAISSAVSRIVWSYGRNGELPGSRHLSRLHPRINTPTTATV VTGAIGIALYLPFQSEQIYTLLVTFVTAGFFMSFGFPIVGLAISKLRGTWDPTEPTFLGRAGHVAGWLAL VWVIVETVNVLWPRTGDPWVDWAPFIVTAALFVIGLVIRARLGLKETSQQTPETANA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6735 | - | - | 100% (478) | amino acid permease, putative |
| M. smegmatis MC2 155 | MSMEG_1069 | - | e-106 | 42.92% (466) | amino acid permease-associated region |
| M. smegmatis MC2 155 | MSMEG_4377 | - | 3e-97 | 38.21% (458) | amino acid permease family protein, putative |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2022c | - | 4e-17 | 24.86% (350) | integral membrane protein |
| M. gilvum PYR-GCK | Mflv_0800 | - | 1e-105 | 42.13% (451) | amino acid permease-associated region |
| M. tuberculosis H37Rv | Rv1999c | - | 5e-17 | 24.86% (350) | integral membrane protein |
| M. leprae Br4923 | MLBr_01974 | - | 7e-17 | 23.89% (406) | putative permease |
| M. abscessus ATCC 19977 | MAB_4090 | - | 2e-45 | 28.60% (500) | putative amino-acid permease |
| M. marinum M | MMAR_0869 | - | 3e-27 | 24.15% (439) | amino acid permease |
| M. avium 104 | MAV_4216 | - | 1e-15 | 21.58% (468) | cationic amino acid transporter |
| M. thermoresistible (build 8) | TH_0471 | - | 5e-16 | 22.55% (470) | POSSIBLE CATIONIC AMINO ACID TRANSPORT INTEGRAL MEMBRANE |
| M. ulcerans Agy99 | MUL_1244 | rocE | 2e-16 | 24.17% (422) | cationic amino acid transport integral membrane protein RocE |
| M. vanbaalenii PYR-1 | Mvan_0043 | - | 1e-104 | 42.13% (451) | amino acid permease-associated region |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2022c|M.bovis_AF2122/97 --------------------------------------------------
Rv1999c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4216|M.avium_104 --------------------------------------------------
TH_0471|M.thermoresistible__bu --------------------------------------------------
MUL_1244|M.ulcerans_Agy99 --------------------------------------------------
Mflv_0800|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0043|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6735|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4090|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_0869|M.marinum_M --------------------------------------------------
MLBr_01974|M.leprae_Br4923 MFLSADVSCIEIVDINCSELRNDRRIPPQLALFCTNAANKAESAVTSHGQ
Mb2022c|M.bovis_AF2122/97 ----------------------------------------MRRPLD----
Rv1999c|M.tuberculosis_H37Rv ----------------------------------------MRRPLD----
MAV_4216|M.avium_104 ------------------------------MASRWRTKSVEQSIAD----
TH_0471|M.thermoresistible__bu ------------------------------MTDRLRVKSVEQSIAD----
MUL_1244|M.ulcerans_Agy99 ---------------------------MPATSIRLREQMLRRRPAGGAPV
Mflv_0800|M.gilvum_PYR-GCK ----------------------------------------MSSLVS----
Mvan_0043|M.vanbaalenii_PYR-1 ----------------------------------------MSISVS----
MSMEG_6735|M.smegmatis_MC2_155 -----------------------------------MDDIATRTTAD----
MAB_4090|M.abscessus_ATCC_1997 ------------------------MNASTATGTAAPSAAISAASDSDDLA
MMAR_0869|M.marinum_M ----------------------------------------MAVTTG----
MLBr_01974|M.leprae_Br4923 LPIMANRRWAPHTRRQSGRATSTCSSLMRFSASESRAHSRFECYTLVRWS
Mb2022c|M.bovis_AF2122/97 PRDIPDELRRRLGLLDAVVIGLGSMIGAGIFAALAPAAY-AAGSGLLLGL
Rv1999c|M.tuberculosis_H37Rv PRDIPDELRRRLGLLDAVVIGLGSMIGAGIFAALAPAAY-AAGSGLLLGL
MAV_4216|M.avium_104 TDEPDTRLRKDLTWWDLVVFGVAVVIGAGIFTVTASTTGDITGPAIWVSF
TH_0471|M.thermoresistible__bu TDEPDSRLRKDLSWWDLTVFGVSVVIGAGIFTVTASTAGNITGPAISVSF
MUL_1244|M.ulcerans_Agy99 AEGAAGSLKRSFGTFELTMFGVGSTVGTGIFFVLAEAVP-EAGPAVIVSF
Mflv_0800|M.gilvum_PYR-GCK PAEQQPQLRREFSLGSAFAFAFAFISPIVALYGIFGLALSAAGPSFWWGF
Mvan_0043|M.vanbaalenii_PYR-1 PAEQPPQLRREFSLGSAFAFAFAFISPIVALYGIFGLALSAAGPSFWWGF
MSMEG_6735|M.smegmatis_MC2_155 TPTAAGPMRREFSMWSAAMLGFVFVSPIVAMYMVFGLGLAAAGPGFWWAL
MAB_4090|M.abscessus_ATCC_1997 AFGYKPQLHRSLGKFASFAAGFSFVSILTTIFQLFAFGFSFGGPAFFWTW
MMAR_0869|M.marinum_M ---ARSELQKALGQRSAVLFGLAYMTPIIVLGIFGVIAERSKGASAG-SY
MLBr_01974|M.leprae_Br4923 IRGQGGRAISKLGFWSVVMLGINSIIGAGIFMTPG-EVIKIAGPFAPIAY
: .. : *.
Mb2022c|M.bovis_AF2122/97 AVAAVVAYCNAISSARLAARYPASGGTYVYGRMRLGDFWGYLAGWGFVVG
Rv1999c|M.tuberculosis_H37Rv AVAAVVAYCNAISSARLAARYPASGGTYVYGRMRLGDFWGYLAGWGFVVG
MAV_4216|M.avium_104 VIAAGTCALAALCYAEFASTLPVAGSAYTFSYATFGEFLAWIIGWNLLLE
TH_0471|M.thermoresistible__bu IIAAIACGLAALCYAEFASTVPVAGSAYTFSYATFGEFVAWIIGWDLILE
MUL_1244|M.ulcerans_Agy99 IIAGVAAGLAAICCAELASAVPVSGSSYSYAYATLGEAVAMGVASCLLLE
Mflv_0800|M.gilvum_PYR-GCK GLVFAGQFLVALVFATLVSRWPLEGSIYQWSRRLLGTAYGWFAGWVYMWT
Mvan_0043|M.vanbaalenii_PYR-1 ALVFAGQFLVALVFAALVSRWPLEGSIYQWSRRLLGSTYGWFAGWVYMWT
MSMEG_6735|M.smegmatis_MC2_155 VVVLIGQVLIGVTFGVLASRWPMAGGVYQWSRRLLGSAYGWFAGWAYMWT
MAB_4090|M.abscessus_ATCC_1997 PIVFLGQYMVALNFAELAARYPISGAIYQWARRLGGAAVGWFAGWFMIIA
MMAR_0869|M.marinum_M LLATVAMLFTAQSYGVMARHFPVAGSAYTYVRKALDARVGFMVGWAVLLD
MLBr_01974|M.leprae_Br4923 TLAGIFAAVLAIVFATAAKYVKTNGSSYAYTTAAFGHRIGIYVGVTHAIT
:. . . . *. * : . . .
Mb2022c|M.bovis_AF2122/97 KTASCAAMALTVGFYVWP---------------------------AQAHA
Rv1999c|M.tuberculosis_H37Rv KTASCAAMALTVGFYVWP---------------------------AQAHA
MAV_4216|M.avium_104 LAIGAAVVAKGWSSYLG----TVFGFSG--------GTVKFGAAQ--LDW
TH_0471|M.thermoresistible__bu FSVAAAVVAKGWSSYLG----EVFEFAG--------ATTRLGPIT--LDW
MUL_1244|M.ulcerans_Agy99 YGVATAAVAVGLSGYVNKLLHNVFGFQLPQALSEAPWDERPGEAAGYLNL
Mflv_0800|M.gilvum_PYR-GCK LVIAMATVALGAAGFTAN------------------IVGIEEPSGGTLAL
Mvan_0043|M.vanbaalenii_PYR-1 LVIAMATVALGAAGFVAH------------------IVGIEEASGGTLAW
MSMEG_6735|M.smegmatis_MC2_155 LLVTLTAVSYGGALFAAA------------------AFDLDAENQKLMTF
MAB_4090|M.abscessus_ATCC_1997 QIVTASAAAIALQVVLPTVWSGFQLIGT-------DSSLTSVSGASNAVL
MMAR_0869|M.marinum_M YLFLPLVIWLIGGSYLQDR-----------------------FPTVPFWT
MLBr_01974|M.leprae_Br4923 ASIAWGVLASSFVSTLLRVAFPEKIWAD------------NDELISVKTL
.
Mb2022c|M.bovis_AF2122/97 VAVAVVVALTAVNYAGIQKSAWLTRSIVAVVLVVLTAVVVAAYGSGAADP
Rv1999c|M.tuberculosis_H37Rv VAVAVVVALTAVNYAGIQKSAWLTRSIVAVVLVVLTAVVVAAYGSGAADP
MAV_4216|M.avium_104 GALVIVGGVATLIALGTKLSSRFSAVITGIKVSVVVFVVVVGVFYIKRAN
TH_0471|M.thermoresistible__bu GALLIIGFVTVLLATGTKLSANVSLAITVIKVGVVLLVVIVGAFFIKAAN
MUL_1244|M.ulcerans_Agy99 PAIILIGLCALLLIRGVSESAKVNAIMVLIKLGVLGMFVILALTAYDTNH
Mflv_0800|M.gilvum_PYR-GCK IALVILLAGTAVNLIGRQALKIFMIGSIIAEVIGSVVLGTWLLIFHRQNS
Mvan_0043|M.vanbaalenii_PYR-1 IALLILLAGTAVNLVGRQALKIFMIGSIIAEVVGSVVLGTWLLLFHRQNS
MSMEG_6735|M.smegmatis_MC2_155 VGMVILAGAVLINVLGRVAVRIVGFLCLVAEVTGSVGIAIWLLCFHKVNS
MAB_4090|M.abscessus_ATCC_1997 LGSLLLVATTAINAVGVNWMSRINSIGVTCEIVGVVAVVGMLFGHAERGP
MMAR_0869|M.marinum_M WIVGFAALTTVLNLIGLKVADRANFILMTFQLLILAFFVALTIGYLVGDS
MLBr_01974|M.leprae_Br4923 TFLVFIAVLLAINIFGNLVIRWANGISALGKIFALSVFIAGGLWTIITQH
. : * : .
Mb2022c|M.bovis_AF2122/97 ARLDIG-------------------------VDAHVWGMLQAAGLLFFAF
Rv1999c|M.tuberculosis_H37Rv ARLDIG-------------------------VDAHVWGMLQAAGLLFFAF
MAV_4216|M.avium_104 YSPFIPKPEAGGQA-KGIDQSVLSLLTGAHTSHYGWYGVLAGASIVFFAF
TH_0471|M.thermoresistible__bu YTPFIPPAEAGGEAGRSLDQSLFSLITGAEGSSYGWYGLLAGASIVFFAF
MUL_1244|M.ulcerans_Agy99 LKDFAP---------------------------FGVAGVGAAAGTIFFSF
Mflv_0800|M.gilvum_PYR-GCK ISVLFEGGG-----------------ADVDLGAYLGGPFLLAVAFIGWSF
Mvan_0043|M.vanbaalenii_PYR-1 LSVLFEGGG-----------------TDVDLWSYLGGPFLLAVAFIGWSF
MSMEG_6735|M.smegmatis_MC2_155 VSSLGSAVS-----------------WPPDT-AFMATPFVLAVMFAGWSF
MAB_4090|M.abscessus_ATCC_1997 SVVLHTGDAG----------------------SGYPWAFLAAGLMAAYVL
MMAR_0869|M.marinum_M RSLLSLTPFTG---------------------NGGFTAITAGAAVAAYSF
MLBr_01974|M.leprae_Br4923 VNNYVTSRSAYQPTTYSLLG-------VTEIGKSTAASMTLATIVALYAF
. . : :
Mb2022c|M.bovis_AF2122/97 AGYARIATLGEEVRDPARTIPRAIPLALGITLAVYALVAVAVIAVLGPQR
Rv1999c|M.tuberculosis_H37Rv AGYARIATLGEEVRDPARTIPRAIPLALGITLAVYALVAVAVIAVLGPQR
MAV_4216|M.avium_104 IGFDIVATMAEETKHPQRDVPRGILASLGIVTLLYVAVAVVLSGMVSYTQ
TH_0471|M.thermoresistible__bu IGFDIIATTAEETKNPQRDVARGIMATLGIVTVLYVAVSLVLTGMVHYTE
MUL_1244|M.ulcerans_Agy99 IGLDAVSTAGEEVRNPQQSVPRALIAALFVVTGVYVLVAFAALGTQPWQM
Mflv_0800|M.gilvum_PYR-GCK VGFESAGSIAEEVHNPRRDLPKAVLFSIAFIALVVGYSALAIILAIPDLD
Mvan_0043|M.vanbaalenii_PYR-1 VGFESAGSIAEEVHNPGRDLPKAVLFSLAFIALVVGYSSLAIILAIPDLD
MSMEG_6735|M.smegmatis_MC2_155 LGFESASTLAEEVGQPKRDIPKAIVGSLIGVGLVVLFTCFAFLMAMPES-
MAB_4090|M.abscessus_ATCC_1997 VGFGSASELAEETRNPRRVAPRTILSAIVVSAIGGALMILGALMAAPSLT
MMAR_0869|M.marinum_M LGFDAVSTLTEETHDAERTIPRAIVLIALIGGAIFVTVAYVVSLVAPGSS
MLBr_01974|M.leprae_Br4923 TGFESIANAAEEMNTPDRTLPKAIPLTILTVGVIYILALVVAMLLGSDKI
* . ** . : .: :
Mb2022c|M.bovis_AF2122/97 LARAA----APLSEAMR-VAGVNWLIPVVQIGAAVAALGSLLALILGVSR
Rv1999c|M.tuberculosis_H37Rv LARAA----APLSEAMR-VAGVNWLIPVVQIGAAVAALGSLLALILGVSR
MAV_4216|M.avium_104 LKTMPGRGQANLATAFT-ANGIHWASKIISIGALAGLTTVVMVLMLGQCR
TH_0471|M.thermoresistible__bu LRAAG--ENANLATAFA-ANGIDWAAKVISIGALAGLTTVVIVLVLGQTR
MUL_1244|M.ulcerans_Agy99 FAGQE---EAGLATILDNVTHSAWASTVLAMGAVISIFTVTLVTMYGQTR
Mflv_0800|M.gilvum_PYR-GCK AVAEGA-VADPVYDTLT-TALGAGIAKPVQVMFVIGFLASFLALQTSASR
Mvan_0043|M.vanbaalenii_PYR-1 AVAEGA-VSDPVYETLT-TALGAGIAKPVQVLFVIGFLASFLALQTSASR
MSMEG_6735|M.smegmatis_MC2_155 AVND----ADPVAATLT-AYLPAPVFKAVMILFVIAYFATVVAISSAVSR
MAB_4090|M.abscessus_ATCC_1997 DGQLAT---GGLPYVLD-SKLASPFGTLLLIDVAIAVFVCTLAIQTAASR
MMAR_0869|M.marinum_M FPDADS-----LSEGVARTIGGNLFAAVFLAALIIGQFTSGLAAQAAVSR
MLBr_01974|M.leprae_Br4923 VATNHT-------VKLAAAVGNNTFRTIIVVGALVSMFGINVAASFGAPR
. . . :. . *
Mb2022c|M.bovis_AF2122/97 TTLAMARDRHLP--RWLAAVHPRFKVPFRAELVVGAVVAALAATADIRG-
Rv1999c|M.tuberculosis_H37Rv TTLAMARDRHLP--RWLAAVHPRFKVPFRAELVVGAVVAALAATADIRG-
MAV_4216|M.avium_104 VLFAMARDGLLP--RALAKTGSR-GTPVRITVLVALVVAVTASVFPITK-
TH_0471|M.thermoresistible__bu VLFAMSRDGLLP--RPLSKTGPR-GTPVRITVLVGALVAIAASVFPVGN-
MUL_1244|M.ulcerans_Agy99 ILFAMGRDGLLP--ARFAAVHPRFQTPVSNTVVVAIAAAVLAALVPLNR-
Mflv_0800|M.gilvum_PYR-GCK VIWAYSRDGALPAAGTLVQLRGKARIPVAAILVTTVIGAALFLLSIVAGD
Mvan_0043|M.vanbaalenii_PYR-1 VIWAYARDGALPAAGTLVQLRGRARIPVVAILVTTVIGAGLFLLSIVAGD
MSMEG_6735|M.smegmatis_MC2_155 IVWSYGRNGELPGSRHLSRLHPRINTPTTATVVTGAIGIALYLP-FQSEQ
MAB_4090|M.abscessus_ATCC_1997 LMFSMARDGKLPFSAVLSHVNPRTGTPIAPAVVVGVCCVLILAVNFGNAA
MMAR_0869|M.marinum_M LLYAMGRDGVLP-RRVFGVVSAKFHTPMFNIMLTGAVGMAAILLSVATS-
MLBr_01974|M.leprae_Br4923 LWTALSDGRILP---TRLSSKNRFGVPIVAFGITAFLTLAFPLSLRFDSL
: . . ** : * :.
Mb2022c|M.bovis_AF2122/97 ----AIGFSSFGVLVYYAIANASALTLGLDE-----------GRPRR---
Rv1999c|M.tuberculosis_H37Rv ----AIGFSSFGVLVYYAIANASALTLGLDE-----------GRPRR---
MAV_4216|M.avium_104 ----LEEMVNVGTLFAFVLVSAGVMVLRRTR-----------PDLERGFK
TH_0471|M.thermoresistible__bu ----LEEMVNIGTLFAFALVSAGVIVLRRTR-----------PDLKRGFR
MUL_1244|M.ulcerans_Agy99 ----LADMVSIGTLTAFIVVSVGVIILRVRE-----------PALPRGFW
Mflv_0800|M.gilvum_PYR-GCK IYSLMVNFTAGGFYLAFLFPLIGFLVVLLRK-----------TWKPGSFS
Mvan_0043|M.vanbaalenii_PYR-1 IYSLMVNFTAGGFYLAFLFPLIGFLVVVLRK-----------VWKPASFS
MSMEG_6735|M.smegmatis_MC2_155 IYTLLVTFVTAGFFMSFGFPIVGLAISKLRG-----------TWDPTEPT
MAB_4090|M.abscessus_ATCC_1997 LFTSLCSVCIALIYLAYLMVTTPLLLRRLGIGGSTWDANLGQTDADGRKL
MMAR_0869|M.marinum_M -----TSFINFGAFTAFTLVNVSVVVYFVRE-------------RGAGLP
MLBr_01974|M.leprae_Br4923 N---LTGLAVIARFIQFIIVPIALFALARSRTTN-------SVYVKRNVF
. : .
Mb2022c|M.bovis_AF2122/97 -----LIPLVGLIGCVVLAFALPLSSVAAGA-------AVLGVGVAAYGV
Rv1999c|M.tuberculosis_H37Rv -----LIPLVGLIGCVVLAFALPLSSVAAGA-------AVLGVGVAAYGV
MAV_4216|M.avium_104 APWVPVLPIASIGACVWLMLNLTALTWVRFG-------IWLVVGTAIYAG
TH_0471|M.thermoresistible__bu VPFVPWLPLAAIAACLWLMLNLTGLTWVRFL-------GWMALGLVLYFF
MUL_1244|M.ulcerans_Agy99 VPGYPVTPILSILACGYLLYSLHWYTWIAFG-------GWVGIALIFYLF
Mflv_0800|M.gilvum_PYR-GCK LRA-ATMPVA-AVAVVWAVLQFLNIAWPRVAFEQRYLDWSVWIGVVVLGI
Mvan_0043|M.vanbaalenii_PYR-1 LRG-WTLPVA-VVAVVWAVLQFLNIAWPRVAFEQRYLDWSVWIGVVVLGM
MSMEG_6735|M.smegmatis_MC2_155 FLG-RAGHVAGWLALVWVIVETVNVLWPRTG--DPWVDWAPFIVTAALFV
MAB_4090|M.abscessus_ATCC_1997 FSLGRCGLPINILAVGYGAFMILNLSWPRPAVFDPTGEHPYLVWMAPICI
MMAR_0869|M.marinum_M RWRYLVLPVIGAAVDIYLLAHLASDALIVGLS-------WAAIGFLYLLW
MLBr_01974|M.leprae_Br4923 TDKVLPITAVVVSAGLMVSFDYRSIFLTRGGP------NYFSISLIAITF
:
Mb2022c|M.bovis_AF2122/97 RRIITRRARQTDSGDTQRSGHPSAT------
Rv1999c|M.tuberculosis_H37Rv RRIITRRARQTDSGDTQRSGHPSAT------
MAV_4216|M.avium_104 YGYWHSVQGRRDAGEPDRSDALAADPNSPVP
TH_0471|M.thermoresistible__bu YGRHHSMLGR---GMTDISARRTG-------
MUL_1244|M.ulcerans_Agy99 WGRHHSRLNA-----PALHDNPTGEER----
Mflv_0800|M.gilvum_PYR-GCK IGAALYASVKSRIVAPRDHDEPALADD----
Mvan_0043|M.vanbaalenii_PYR-1 IGAVLFATVKSRIAAPQDQDDRALVDD----
MSMEG_6735|M.smegmatis_MC2_155 IGLVIRARLGLKETSQQTPETANA-------
MAB_4090|M.abscessus_ATCC_1997 IAVLLAGLVAYPRHTASTTEETVR-------
MMAR_0869|M.marinum_M LTRGLTRQPPDLAGAAERG------------
MLBr_01974|M.leprae_Br4923 IGIPAVAYLHYYRTSGIK-------------