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SESLQTGPRTDTGDAGLRRGVMGGGELAAQAIANIAPSAVIAFTAAAIYTTASGGTWISFALATVVILSV GYCISQFAKRRSSAGSLYSYAATALGPFGAYLTGVSLLIGCFGIAAGSLSGAVAYTATLLNQLGLAVGGL AAQIVLAIVLGSLATLFTIRGIRLSARISLVLELVSVSIITVLLVVTLVHLGPDAFDADQFRLSDVKPSG IVVGMVLAILGFVGFSSADALAREAKDPYRAVPRAIMWSAAGVGVLYVFAAYTQVAALGPALGESAQPLD DIATLVGMPTWFNPILNFGIAASFFAVVVAPMNVIGRILYVMGKEGVVPSAIGRTHPTHLTPHRALITVA PLVIAVPVVMYLRDVAPMDVVTWVDTYGTYGYMVAYAAAALAAVVYLRSINARVPLVWPAAIVAIVSMAY VFYANVYPVPPYPLNVIPWLFILTVAAALAWYLILRRRSPHVVANIGTSDVETLEGIG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1137 | - | - | 100% (479) | amino acid permease-associated region |
| M. smegmatis MC2 155 | MSMEG_4549 | - | 4e-61 | 29.46% (465) | amino acid permease-associated region, putative |
| M. smegmatis MC2 155 | MSMEG_0812 | - | 1e-25 | 28.24% (347) | amino acid transporter |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2347c | rocE | 9e-26 | 25.64% (472) | cationic amino acid transport integral membrane protein RocE |
| M. gilvum PYR-GCK | Mflv_1244 | - | 4e-28 | 24.88% (418) | amino acid permease-associated region |
| M. tuberculosis H37Rv | Rv2320c | rocE | 9e-26 | 25.64% (472) | cationic amino acid transport integral membrane protein RocE |
| M. leprae Br4923 | MLBr_01974 | - | 6e-08 | 23.58% (318) | putative permease |
| M. abscessus ATCC 19977 | MAB_4122 | - | 7e-60 | 29.63% (459) | putative amino acid permease |
| M. marinum M | MMAR_2407 | rocE_1 | 5e-26 | 25.70% (463) | cationic amino acid transport integral membrane protein, |
| M. avium 104 | MAV_4216 | - | 2e-27 | 27.86% (384) | cationic amino acid transporter |
| M. thermoresistible (build 8) | TH_4382 | - | 2e-21 | 25.45% (440) | PUTATIVE amino acid permease-associated region |
| M. ulcerans Agy99 | MUL_1244 | rocE | 2e-24 | 24.78% (464) | cationic amino acid transport integral membrane protein RocE |
| M. vanbaalenii PYR-1 | Mvan_2919 | - | 4e-29 | 25.65% (382) | amino acid permease-associated region |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2347c|M.bovis_AF2122/97 -----------------------------------------------MPT
Rv2320c|M.tuberculosis_H37Rv -----------------------------------------------MPT
MUL_1244|M.ulcerans_Agy99 -----------------------------------------------MPA
MMAR_2407|M.marinum_M -----------------------------------------------MAA
MAV_4216|M.avium_104 --------------------------------------------------
TH_4382|M.thermoresistible__bu --------------------------------------------------
MLBr_01974|M.leprae_Br4923 MFLSADVSCIEIVDINCSELRNDRRIPPQLALFCTNAANKAESAVTSHGQ
MSMEG_1137|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4122|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_2919|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1244|M.gilvum_PYR-GCK --------------------------------------------------
Mb2347c|M.bovis_AF2122/97 TSMSLRELMLRRRPVSGAPVASGASGNLKR--------------------
Rv2320c|M.tuberculosis_H37Rv TSMSLRELMLRRRPVSGAPVASGASGNLKR--------------------
MUL_1244|M.ulcerans_Agy99 TSIRLREQMLRRRPAGGAPVAEGAAGSLKR--------------------
MMAR_2407|M.marinum_M PTIGLIQQMLRRRPVIGAPVAHGASDQLKR--------------------
MAV_4216|M.avium_104 ----MASRWRTKSVEQSIADTDEPDTRLRK--------------------
TH_4382|M.thermoresistible__bu ---------------MSGTRTEQAQPELRR--------------------
MLBr_01974|M.leprae_Br4923 LPIMANRRWAPHTRRQSGRATSTCSSLMRFSASESRAHSRFECYTLVRWS
MSMEG_1137|M.smegmatis_MC2_155 ----------MSESLQTGPRTDTGDAGLRRG-------------------
MAB_4122|M.abscessus_ATCC_1997 -----MSSATHQLTVNGRSLRTADSHGLER--------------------
Mvan_2919|M.vanbaalenii_PYR-1 -----------MNPEASETSEEIDQIPHRR--------------------
Mflv_1244|M.gilvum_PYR-GCK ------MTESAERTAPGQTTPTASVQRLKRN-------------------
.
Mb2347c|M.bovis_AF2122/97 ----------SFGTFQLTMFGVGATIGTGIFF-VLAQAVPEAG-PGVIVS
Rv2320c|M.tuberculosis_H37Rv ----------SFGTFQLTMFGVGATIGTGIFF-VLAQAVPEAG-PGVIVS
MUL_1244|M.ulcerans_Agy99 ----------SFGTFELTMFGVGSTVGTGIFF-VLAEAVPEAG-PAVIVS
MMAR_2407|M.marinum_M ----------SIGTFQLTLFGVGATVGTGIFF-VLSEAVPEAG-PGVVAS
MAV_4216|M.avium_104 ----------DLTWWDLVVFGVAVVIGAGIFT-VTASTTGDITGPAIWVS
TH_4382|M.thermoresistible__bu ----------VLGPGLLLLFIVGDILGTGIYA-LVGDVAGEVG-GAAWLP
MLBr_01974|M.leprae_Br4923 IRGQGGRAISKLGFWSVVMLGINSIIGAGIFM-TPGEVIKIAG-PFAPIA
MSMEG_1137|M.smegmatis_MC2_155 ----------VMGGGELAAQAIANIAPSAVIA-FTAAAIYTTASGGTWIS
MAB_4122|M.abscessus_ATCC_1997 ---------DAIGSWGVFAQGLAAAAPSVAVA-TVPFSLFVAAGKGAAWS
Mvan_2919|M.vanbaalenii_PYR-1 -----------LPFWVALALSVALVGPTLAMS-GNGQGLIGTVGKSIPLV
Mflv_1244|M.gilvum_PYR-GCK ----------AVGTFGVIFMAVATAAPITAMVGNVPIAVGFGNGSHAPAG
. :
Mb2347c|M.bovis_AF2122/97 FIIAGIAAGLAAICYAELASAVPISGSAYSYAYTTLGEAVAMVVAACLLL
Rv2320c|M.tuberculosis_H37Rv FIIAGIAAGLAAICYAELASAVPISGSAYSYAYTTLGEAVAMVVAACLLL
MUL_1244|M.ulcerans_Agy99 FIIAGVAAGLAAICCAELASAVPVSGSSYSYAYATLGEAVAMGVASCLLL
MMAR_2407|M.marinum_M FVIAGIAAGLAAVCYAELASAVPVSGSTYSYAYTTLGELVAMGVAACLLL
MAV_4216|M.avium_104 FVIAAGTCALAALCYAEFASTLPVAGSAYTFSYATFGEFLAWIIGWNLLL
TH_4382|M.thermoresistible__bu FLIAFLIATVTAFSYLELVTKYPQAAGAALYVHKAFGIQFVTFLVAFIVM
MLBr_01974|M.leprae_Br4923 YTLAGIFAAVLAIVFATAAKYVKTNGSSYAYTTAAFGHRIGIYVGVTHAI
MSMEG_1137|M.smegmatis_MC2_155 FALATVVILSVGYCISQFAKRRSSAGSLYSYAATALGPFGAYLTGVSLLI
MAB_4122|M.abscessus_ATCC_1997 AVIGLVAVVLIATTISFQAKRTVSSGSLGTYAGNGLGPGAAYAAGFSLLI
Mvan_2919|M.vanbaalenii_PYR-1 FLIGLVGVSLVGYSFVRLTRHLNHAGSAYGLVGGTIGPRTGFFSGFAMLG
Mflv_1244|M.gilvum_PYR-GCK YLVATIVLGLFAIGYATMAKHITATGAFYGYISHGLGRVMGMASGLIITL
:. . . .. :*
Mb2347c|M.bovis_AF2122/97 -EYGVATAAVAVGWSGYVNKLLSNLFGFQMPHVLSAAPW-DTHPG----W
Rv2320c|M.tuberculosis_H37Rv -EYGVATAAVAVGWSGYVNKLLSNLFGFQMPHVLSAAPW-DTHPG----W
MUL_1244|M.ulcerans_Agy99 -EYGVATAAVAVGLSGYVNKLLHNVFGFQLPQALSEAPW-DERPGEAAGY
MMAR_2407|M.marinum_M -EYGVSTAAVAVGWSQYVNKLLDNFFGHHLPQALSAAPWGDASPG----I
MAV_4216|M.avium_104 -ELAIGAAVVAKGWSSYLG----TVFGFSGGTVKFGAAQ-----------
TH_4382|M.thermoresistible__bu -CSGITSASTAS---RFFAANLEVGLGQEWGRLG----------------
MLBr_01974|M.leprae_Br4923 -TASIAWGVLAS---SFVSTLLRVAFPEKIWADNDELIS----------V
MSMEG_1137|M.smegmatis_MC2_155 GCFGIAAGSLSG--AVAYTATLLNQLGLAVGGLAAQIVL-----------
MAB_4122|M.abscessus_ATCC_1997 GYITFATTGTLGG--VLYFESFLDVIGIHSEANGFKLAL-----------
Mvan_2919|M.vanbaalenii_PYR-1 AYWGFSIGTLALTAAFVNSFIAALQPGDETPYQAPWLL------------
Mflv_1244|M.gilvum_PYR-GCK -AYIVFEASLIGIFAFFFQNFLSSQLGITIHWLVP---------------
.
Mb2347c|M.bovis_AF2122/97 VNLPAVILIGLCALLLIRGASESARVNAIMVLIKLGVLGMFMIIAFSAYS
Rv2320c|M.tuberculosis_H37Rv VNLPAVILIGLCALLLIRGASESARVNAIMVLIKLGVLGMFMIIAFSAYS
MUL_1244|M.ulcerans_Agy99 LNLPAIILIGLCALLLIRGVSESAKVNAIMVLIKLGVLGMFVILALTAYD
MMAR_2407|M.marinum_M INLPAVVLVGLCAVLLIRGASESAKVNTIMVLIKLSVLVMFAVIALTAFD
MAV_4216|M.avium_104 LDWGALVIVGGVATLIALGTKLSSRFSAVITGIKVSVVVFVVVVGVFYIK
TH_4382|M.thermoresistible__bu VAGVALLFMALLAMVNLRGVGESVRLNVLLTIVEISGLLLVIFVGLWAFT
MLBr_01974|M.leprae_Br4923 KTLTFLVFIAVLLAINIFGNLVIRWANGISALGKIFALSVFIAGGLWTII
MSMEG_1137|M.smegmatis_MC2_155 ----AIVLGSLATLFTIRGIRLSARISLVLELVSVSIITVLLVVTLVHLG
MAB_4122|M.abscessus_ATCC_1997 ----VALVVAFAVYLPYRGVSISAKYELIFEIIATALILIIIVASYISYG
Mvan_2919|M.vanbaalenii_PYR-1 -----IVVIGAVISFLLSGRDIQLLAKILLAIEGIGILAMIVLVVAIFAQ
Mflv_1244|M.gilvum_PYR-GCK ----ALLMLVLNSILTYFDVNLTAKVLGVFLITEIFMLALGAVAVAVKGG
:. . . : : .
Mb2347c|M.bovis_AF2122/97 ADHLKDFVP--------------------------FGVAGIGSAAGTIFF
Rv2320c|M.tuberculosis_H37Rv ADHLKDFVP--------------------------FGVAGIGSAAGTIFF
MUL_1244|M.ulcerans_Agy99 TNHLKDFAP--------------------------FGVAGVGAAAGTIFF
MMAR_2407|M.marinum_M ADRFAEFAP--------------------------FGVAGIGAAAGTIFF
MAV_4216|M.avium_104 RANYSPFIPKPEAGGQAKGIDQSVLSLLTGAHTSHYGWYGVLAGASIVFF
TH_4382|M.thermoresistible__bu GGGADVDFTR---------------VVAFETTTDKSVFLAVSAATSLAFF
MLBr_01974|M.leprae_Br4923 TQHVNNYVTSR------SAYQPTTYSLLGVTEIGKSTAASMTLATIVALY
MSMEG_1137|M.smegmatis_MC2_155 PDAFDADQFR----------------------LSDVKPSGIVVGMVLAIL
MAB_4122|M.abscessus_ATCC_1997 WRIDTEQWALTN-----------------------LGNSTTFIAAVTAVG
Mvan_2919|M.vanbaalenii_PYR-1 GGAPGTGIDFS----------------VFSFSDGDVSGSAVLAGVVAAFL
Mflv_1244|M.gilvum_PYR-GCK GPDGFAIAETLN--------------PVGAFQPAAIAGASAGLGLFFAFW
. .
Mb2347c|M.bovis_AF2122/97 SYIGLDAVSTAGDEVKDPQKTMPRALIAALVVVTGVYVLVALAALGTQ-P
Rv2320c|M.tuberculosis_H37Rv SYIGLDAVSTAGDEVKDPQKTMPRALIAALVVVTGVYVLVALAALGTQ-P
MUL_1244|M.ulcerans_Agy99 SFIGLDAVSTAGEEVRNPQQSVPRALIAALFVVTGVYVLVAFAALGTQ-P
MMAR_2407|M.marinum_M SYIGLDAVSTAGDEVKNPQKTMPLAIMAALVTVTTVYVVVTVAALGAQ-P
MAV_4216|M.avium_104 AFIGFDIVATMAEETKHPQRDVPRGILASLGIVTLLYVAVAVVLSGMV-S
TH_4382|M.thermoresistible__bu AMVGFEDSVNMAEETRDPVVIFPRALLTGLGIAGAVYVVVAIVAVALV-P
MLBr_01974|M.leprae_Br4923 AFTGFESIANAAEEMNTPDRTLPKAIPLTILTVGVIYILALVVAMLLG-S
MSMEG_1137|M.smegmatis_MC2_155 GFVGFSSADALAREAKDPYRAVPRAIMWSAAGVGVLYVFAAYTQVAALGP
MAB_4122|M.abscessus_ATCC_1997 AYAGFESVASLGAESRDAHRTIARSLLRVVLIIGVLYILATYPQILQFRN
Mvan_2919|M.vanbaalenii_PYR-1 SWAGFEACASMGEETDDPKRNIPRALGGTLILTGVLFVVVMFAQVVGFGT
Mflv_1244|M.gilvum_PYR-GCK SWVGFESTAMYGEESKDPKRIIPRATMIAVLGVGIFYVFVSWMAIAGTGP
. *:. . * . .. . .:: .
Mb2347c|M.bovis_AF2122/97 WQDFAEQETAGLAIILDNVTHG----EWASTILAAGAVVSIFTVTLVTMY
Rv2320c|M.tuberculosis_H37Rv WQDFAEQETAGLAIILDNVTHG----EWASTILAAGAVVSIFTVTLVTMY
MUL_1244|M.ulcerans_Agy99 WQMFAGQEEAGLATILDNVTHS----AWASTVLAMGAVISIFTVTLVTMY
MMAR_2407|M.marinum_M WRDFEGQQ-AGLATVLDRVVSG----HYWGSVLAAGAVISIFSVTLVVLY
MAV_4216|M.avium_104 YTQLKTMPGRGQANLATAFTANGI--HWASKIISIGALAGLTTVVMVLML
TH_4382|M.thermoresistible__bu VGTLQASDVPLVEVVKAGAPGLP-----IEELLPWISMFAVSNTALINML
MLBr_01974|M.leprae_Br4923 DKIVATNHTVKLAAAVGNNTFR--------TIIVVGALVSMFGINVAASF
MSMEG_1137|M.smegmatis_MC2_155 ALGESAQPLDDIATLVGMPTWFN-------PILNFGIAASFFAVVVAPMN
MAB_4122|M.abscessus_ATCC_1997 IDGDSAILPQIATNAGVAWAIYP---------ISLAVTIAFIVFVTAVIN
Mvan_2919|M.vanbaalenii_PYR-1 DAAGLEAFQSSGNTLGDLGGTYIG--QWFSLVIIFTAIVSAFGCHLATSA
Mflv_1244|M.gilvum_PYR-GCK QQAVELAQSADTSSEIFFAPVRDTYGEWAITLFNILLVTGSFACGMAFHN
: .
Mb2347c|M.bovis_AF2122/97 GQTRILFAMGRDGLLP---ARFAKVNPRTMTPVHNTVIVAIFAS------
Rv2320c|M.tuberculosis_H37Rv GQTRILFAMGRDGLLP---ARFAKVNPRTMTPVHNTVIVAIFAS------
MUL_1244|M.ulcerans_Agy99 GQTRILFAMGRDGLLP---ARFAAVHPRFQTPVSNTVVVAIAAA------
MMAR_2407|M.marinum_M GQTRILFAMGRDGLLP---PVFAKVRPPNMTPVYNTIIVAVVIC------
MAV_4216|M.avium_104 GQCRVLFAMARDGLLP---RALAKTGSR-GTPVRITVLVALVVA------
TH_4382|M.thermoresistible__bu MASRLIYGMARQRVLP---PVLGSVHPRRRTPWVAIIFTTLIAFGLIFYV
MLBr_01974|M.leprae_Br4923 GAPRLWTALSDGRILP---TRLS-SKNRFGVPIVAFGITAFLTLAFP---
MSMEG_1137|M.smegmatis_MC2_155 VIGRILYVMGKEGVVP---SAIGRTHPTHLTPHRALITVAPLVIAVP-VV
MAB_4122|M.abscessus_ATCC_1997 SAARGLFTLAHEGALP---AVLTRVHPTYKTPVAGIFLIGIIATAFS-VT
Mvan_2919|M.vanbaalenii_PYR-1 TSGRMLYAFGRDGFGP---KALAHIHAETGGPRRATWLVVVVALLVDLIC
Mflv_1244|M.gilvum_PYR-GCK CASRYLYALGREGLSTGLQKTLGATHKTHGSPYIASFVQSGIALVLVLAF
* :. . : *
Mb2347c|M.bovis_AF2122/97 ------------TLAAFIPLDSLADMVSIGTLTAFSVVAVGVIVLRVREP
Rv2320c|M.tuberculosis_H37Rv ------------TLAAFIPLDSLADMVSIGTLTAFSVVAVGVIVLRVREP
MUL_1244|M.ulcerans_Agy99 ------------VLAALVPLNRLADMVSIGTLTAFIVVSVGVIILRVREP
MMAR_2407|M.marinum_M ------------ILAGFVPLSYLADVVSIGTLVAFIVVSVGVVILRVREP
MAV_4216|M.avium_104 ------------VTASVFPITKLEEMVNVGTLFAFVLVSAGVMVLRRTRP
TH_4382|M.thermoresistible__bu -----------TAFADSTAIAVLGGTTSLLLLAVFAMVNVAVLVLRRDES
MLBr_01974|M.leprae_Br4923 -------------LSLRFDSLNLTGLAVIARFIQFIIVPIALFALARSRT
MSMEG_1137|M.smegmatis_MC2_155 -----------MYLRDVAPMDVVTWVDTYGTYGYMVAYAAAALAAVVYLR
MAB_4122|M.abscessus_ATCC_1997 -----------ATLSSVGRLVFDVYGNYVANWGFLVSYLLVVVATPIWLY
Mvan_2919|M.vanbaalenii_PYR-1 GATGWPDMGTGNAAINTYFLFAVAGSVCLMVCYLLVEIAAAYFVGAPKFE
Mflv_1244|M.gilvum_PYR-GCK FFAG------MDPYIHMYTLLAILGTMAILIVQSLCAFSVVAYFHFHKNH
:
Mb2347c|M.bovis_AF2122/97 D----LPRGFKVPGYPVTPVLSVLACGYILAS----LHWYTWLAFS--GW
Rv2320c|M.tuberculosis_H37Rv D----LPRGFKVPGYPVTPVLSVLACGYILAS----LHWYTWLAFS--GW
MUL_1244|M.ulcerans_Agy99 A----LPRGFWVPGYPVTPILSILACGYLLYS----LHWYTWIAFG--GW
MMAR_2407|M.marinum_M D----LPRGFKVPLYPVTPVLSVLACGYILFS----LPWYTWLAFS--IW
MAV_4216|M.avium_104 D----LERGFKAPWVPVLPIASIGACVWLMLN----LTALTWVRFG--IW
TH_4382|M.thermoresistible__bu RDPVVARRHFRTP--TFLPVVGFVASLYLVTP----LSGRPAQQYL--LS
MLBr_01974|M.leprae_Br4923 TNSVYVKRNVFTD--KVLPITAVVVSAGLMVS----FDYRSIFLTR--GG
MSMEG_1137|M.smegmatis_MC2_155 S------INARVPLVWPAAIVAIVSMAYVFYANVYPVPPYPLNVIP--WL
MAB_4122|M.abscessus_ATCC_1997 R------IKALTPARLSVSAAATVAIGYVIFSNFYPIPKFPFNILP--LI
Mvan_2919|M.vanbaalenii_PYR-1 S----VHGGTGRVAGLVLPLLGAVVIVTVLWFNVKDADSWSAAPMLGLYW
Mflv_1244|M.gilvum_PYR-GCK P---SSAHWFKTFLAPLTGGIGMLYVVYLLWEHKESAAGAASGTLLF-KL
. :. .
Mb2347c|M.bovis_AF2122/97 VAVAVIFYLMWGRHHSALN-------EEVP--------------------
Rv2320c|M.tuberculosis_H37Rv VAVAVIFYLMWGRHHSALN-------EEVP--------------------
MUL_1244|M.ulcerans_Agy99 VGIALIFYLFWGRHHSRLN-------APALHDNPTGEER-----------
MMAR_2407|M.marinum_M VSVVLVFYFVWGRHHSALNDGGDGVIGAMPADAGDSDVLAQRDH------
MAV_4216|M.avium_104 LVVGTAIYAGYGYWHSVQGRRDAGEPDRSDALAADPNSPVP---------
TH_4382|M.thermoresistible__bu VVLIVIGVLLFGVTMAINRQLG----IPTRAVGDPAKMVLPPD-------
MLBr_01974|M.leprae_Br4923 PNYFSISLIAITFIG-----------IPAVAYLHYYRTSGIK--------
MSMEG_1137|M.smegmatis_MC2_155 FILTVAAALAWYLILRRRS-------PHVVANIGTSDVETLEGIG-----
MAB_4122|M.abscessus_ATCC_1997 FGAILLAGLLRYWYLRILRPEVAARIGSIQTLSESEKERLAELGILEVLH
Mvan_2919|M.vanbaalenii_PYR-1 CALGLVIAVALSGIAKRVGESLAIELELVPRPTGAVEPTQPA--------
Mflv_1244|M.gilvum_PYR-GCK TPWIVVGVFAFGAAMALYFKFKDKRRYELIGRIVYDDSEVRD--------
Mb2347c|M.bovis_AF2122/97 -------------------
Rv2320c|M.tuberculosis_H37Rv -------------------
MUL_1244|M.ulcerans_Agy99 -------------------
MMAR_2407|M.marinum_M -------------------
MAV_4216|M.avium_104 -------------------
TH_4382|M.thermoresistible__bu -------------------
MLBr_01974|M.leprae_Br4923 -------------------
MSMEG_1137|M.smegmatis_MC2_155 -------------------
MAB_4122|M.abscessus_ATCC_1997 EEPAAEPVPEPVDTGVLVK
Mvan_2919|M.vanbaalenii_PYR-1 -------------------
Mflv_1244|M.gilvum_PYR-GCK -------------------