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NPEASETSEEIDQIPHRRLPFWVALALSVALVGPTLAMSGNGQGLIGTVGKSIPLVFLIGLVGVSLVGYS FVRLTRHLNHAGSAYGLVGGTIGPRTGFFSGFAMLGAYWGFSIGTLALTAAFVNSFIAALQPGDETPYQA PWLLIVVIGAVISFLLSGRDIQLLAKILLAIEGIGILAMIVLVVAIFAQGGAPGTGIDFSVFSFSDGDVS GSAVLAGVVAAFLSWAGFEACASMGEETDDPKRNIPRALGGTLILTGVLFVVVMFAQVVGFGTDAAGLEA FQSSGNTLGDLGGTYIGQWFSLVIIFTAIVSAFGCHLATSATSGRMLYAFGRDGFGPKALAHIHAETGGP RRATWLVVVVALLVDLICGATGWPDMGTGNAAINTYFLFAVAGSVCLMVCYLLVEIAAAYFVGAPKFESV HGGTGRVAGLVLPLLGAVVIVTVLWFNVKDADSWSAAPMLGLYWCALGLVIAVALSGIAKRVGESLAIEL ELVPRPTGAVEPTQPA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2919 | - | - | 100% (507) | amino acid permease-associated region |
| M. vanbaalenii PYR-1 | Mvan_0605 | - | 2e-37 | 26.91% (457) | amino acid permease-associated region |
| M. vanbaalenii PYR-1 | Mvan_5564 | - | 3e-35 | 24.61% (508) | amino acid permease-associated region |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2347c | rocE | 3e-19 | 24.24% (330) | cationic amino acid transport integral membrane protein RocE |
| M. gilvum PYR-GCK | Mflv_1244 | - | 5e-35 | 25.42% (476) | amino acid permease-associated region |
| M. tuberculosis H37Rv | Rv2320c | rocE | 3e-19 | 24.24% (330) | cationic amino acid transport integral membrane protein RocE |
| M. leprae Br4923 | MLBr_01974 | - | 3e-12 | 19.77% (344) | putative permease |
| M. abscessus ATCC 19977 | MAB_0950c | - | 3e-34 | 27.66% (488) | putative amino acid permease family protein |
| M. marinum M | MMAR_0869 | - | 2e-23 | 27.78% (432) | amino acid permease |
| M. avium 104 | MAV_4216 | - | 1e-18 | 24.53% (424) | cationic amino acid transporter |
| M. smegmatis MC2 155 | MSMEG_1118 | - | 1e-36 | 27.02% (433) | amino acid permease |
| M. thermoresistible (build 8) | TH_0471 | - | 2e-19 | 21.67% (480) | POSSIBLE CATIONIC AMINO ACID TRANSPORT INTEGRAL MEMBRANE |
| M. ulcerans Agy99 | MUL_1244 | rocE | 2e-19 | 24.04% (366) | cationic amino acid transport integral membrane protein RocE |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2347c|M.bovis_AF2122/97 --------------------------------------------------
Rv2320c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_1244|M.ulcerans_Agy99 --------------------------------------------------
MAV_4216|M.avium_104 --------------------------------------------------
TH_0471|M.thermoresistible__bu --------------------------------------------------
Mflv_1244|M.gilvum_PYR-GCK --------------------------------------------------
MAB_0950c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_1118|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_0869|M.marinum_M --------------------------------------------------
Mvan_2919|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_01974|M.leprae_Br4923 MFLSADVSCIEIVDINCSELRNDRRIPPQLALFCTNAANKAESAVTSHGQ
Mb2347c|M.bovis_AF2122/97 ---------------------------MPTTSMSLRELMLRRRPVSGAPV
Rv2320c|M.tuberculosis_H37Rv ---------------------------MPTTSMSLRELMLRRRPVSGAPV
MUL_1244|M.ulcerans_Agy99 ---------------------------MPATSIRLREQMLRRRPAGGAPV
MAV_4216|M.avium_104 ------------------------------MASRWRTKSVEQSIAD----
TH_0471|M.thermoresistible__bu ------------------------------MTDRLRVKSVEQSIAD----
Mflv_1244|M.gilvum_PYR-GCK ------------------------------MTESAERTAPGQTTPT----
MAB_0950c|M.abscessus_ATCC_199 ------------------------------MSDTID-PPVGTTTEP----
MSMEG_1118|M.smegmatis_MC2_155 ------------------------------MSEDVS-----EIHRS----
MMAR_0869|M.marinum_M -----------------------------------------MAVTT----
Mvan_2919|M.vanbaalenii_PYR-1 -------------------------------------MNPEASETS----
MLBr_01974|M.leprae_Br4923 LPIMANRRWAPHTRRQSGRATSTCSSLMRFSASESRAHSRFECYTLVRWS
Mb2347c|M.bovis_AF2122/97 ASGASGNLKRSFGTFQLTMFGVGATIG--TGIFFVLAQAVP-EAGPGVIV
Rv2320c|M.tuberculosis_H37Rv ASGASGNLKRSFGTFQLTMFGVGATIG--TGIFFVLAQAVP-EAGPGVIV
MUL_1244|M.ulcerans_Agy99 AEGAAGSLKRSFGTFELTMFGVGSTVG--TGIFFVLAEAVP-EAGPAVIV
MAV_4216|M.avium_104 TDEPDTRLRKDLTWWDLVVFGVAVVIG--AGIFTVTASTTGDITGPAIWV
TH_0471|M.thermoresistible__bu TDEPDSRLRKDLSWWDLTVFGVSVVIG--AGIFTVTASTAGNITGPAISV
Mflv_1244|M.gilvum_PYR-GCK --ASVQRLKRNAVGTFGVIFMAVATAAPITAMVGNVPIAVGFGNGSHAPA
MAB_0950c|M.abscessus_ATCC_199 --DSMQRLKPNAVGLIGVLFMAVATAAPITAMVGNVPMAVGFGNGAYAPA
MSMEG_1118|M.smegmatis_MC2_155 --ARENRLKPNALGLTSVVFMVVATAAPITAITSNMPIMVGLGTGVGTPA
MMAR_0869|M.marinum_M --GARSELQKALGQRSAVLFGLAYMTP---IIVLGIFGVIAERSKGASAG
Mvan_2919|M.vanbaalenii_PYR-1 --EEIDQIPHRRLPFWVALALSVALVGPTLAMSGNGQGLIG-TVGKSIPL
MLBr_01974|M.leprae_Br4923 IRGQGGRAISKLGFWSVVMLGINSIIG---AGIFMTPGEVIKIAGPFAPI
.:
Mb2347c|M.bovis_AF2122/97 SFIIAGIAAGLAAICYAELASAVPISGSAYSYAYTTLGEAVAMVVAACLL
Rv2320c|M.tuberculosis_H37Rv SFIIAGIAAGLAAICYAELASAVPISGSAYSYAYTTLGEAVAMVVAACLL
MUL_1244|M.ulcerans_Agy99 SFIIAGVAAGLAAICCAELASAVPVSGSSYSYAYATLGEAVAMGVASCLL
MAV_4216|M.avium_104 SFVIAAGTCALAALCYAEFASTLPVAGSAYTFSYATFGEFLAWIIGWNLL
TH_0471|M.thermoresistible__bu SFIIAAIACGLAALCYAEFASTVPVAGSAYTFSYATFGEFVAWIIGWDLI
Mflv_1244|M.gilvum_PYR-GCK GYLVATIVLGLFAIGYATMAKHITATGAFYGYISHGLGRVMGMASGLIIT
MAB_0950c|M.abscessus_ATCC_199 GYLVATIVLTLFAIGYAAMSRHIVATGAFYGYISHGLGRVVGLGSGFLIT
MSMEG_1118|M.smegmatis_MC2_155 GFLLATVTLSIFSVGFVAIARHVTSAGAFYGFISRGLGRIVGLGSGLLTT
MMAR_0869|M.marinum_M SYLLATVAMLFTAQSYGVMARHFPVAGSAYTYVRKALDARVGFMVGWAVL
Mvan_2919|M.vanbaalenii_PYR-1 VFLIGLVGVSLVGYSFVRLTRHLNHAGSAYGLVGGTIGPRTGFFSGFAML
MLBr_01974|M.leprae_Br4923 AYTLAGIFAAVLAIVFATAAKYVKTNGSSYAYTTAAFGHRIGIYVGVTHA
: :. . . : . *: * :. . .
Mb2347c|M.bovis_AF2122/97 LEYGVATAAVAVGWSGYVNKLLSNLFGFQMPHVLSAAPWDTHPG----WV
Rv2320c|M.tuberculosis_H37Rv LEYGVATAAVAVGWSGYVNKLLSNLFGFQMPHVLSAAPWDTHPG----WV
MUL_1244|M.ulcerans_Agy99 LEYGVATAAVAVGLSGYVNKLLHNVFGFQLPQALSEAPWDERPGEAAGYL
MAV_4216|M.avium_104 LELAIGAAVVAKGWSSYLG----TVFGFSGGTVKFGAAQ----------L
TH_0471|M.thermoresistible__bu LEFSVAAAVVAKGWSSYLG----EVFEFAGATTRLGPIT----------L
Mflv_1244|M.gilvum_PYR-GCK LAYIVFEASLIGIFAFFFQNFLSSQLGITIHWLVP---------------
MAB_0950c|M.abscessus_ATCC_199 LAYMVFEASLVGIFSFFANDLFQTFFQVDVPWVVF---------------
MSMEG_1118|M.smegmatis_MC2_155 ASYMMFEVTLVALFGVFTKETMAAELGVDLPWWVY---------------
MMAR_0869|M.marinum_M LDYLFLPLVIWLIGGSYLQDRFPTVPFWTW--------------------
Mvan_2919|M.vanbaalenii_PYR-1 GAYWGFSIGTLALTAAFVNSFIAALQPGDETPYQAP--------------
MLBr_01974|M.leprae_Br4923 ITASIAWGVLASSFVSTLLRVAFPEKIWADNDELISVKT-----------
Mb2347c|M.bovis_AF2122/97 NLPAVILIGLCALLLIRGASESARVNAIMVLIKLGVLGMFMIIAFSAYSA
Rv2320c|M.tuberculosis_H37Rv NLPAVILIGLCALLLIRGASESARVNAIMVLIKLGVLGMFMIIAFSAYSA
MUL_1244|M.ulcerans_Agy99 NLPAIILIGLCALLLIRGVSESAKVNAIMVLIKLGVLGMFVILALTAYDT
MAV_4216|M.avium_104 DWGALVIVGGVATLIALGTKLSSRFSAVITGIKVSVVVFVVVVGVFYIKR
TH_0471|M.thermoresistible__bu DWGALLIIGFVTVLLATGTKLSANVSLAITVIKVGVVLLVVIVGAFFIKA
Mflv_1244|M.gilvum_PYR-GCK ---ALLMLVLNSILTYFDVNLTAKVLGVFLITEIFMLALGAVAVAVKGGG
MAB_0950c|M.abscessus_ATCC_199 ---AVAMLATNAVLTYFDLNLAARVLGVFLVTEILMLSLLALSVLFAGGG
MSMEG_1118|M.smegmatis_MC2_155 ---TFTLIAVIAVLTYFEIELTAKVLGIALAAEVLILAAIALAVLANGGG
MMAR_0869|M.marinum_M ---IVGFAALTTVLNLIGLKVADRANFILMTFQLLILAFFVALTIGYLVG
Mvan_2919|M.vanbaalenii_PYR-1 -WLLIVVIGAVISFLLSGRDIQLLAKILLAIEGIGILAMIVLVVAIFAQG
MLBr_01974|M.leprae_Br4923 -LTFLVFIAVLLAINIFGNLVIRWANGISALGKIFALSVFIAGGLWTIIT
. . : : :
Mb2347c|M.bovis_AF2122/97 ---DHLKDFVP---------------------------FGVAGIGSAAGT
Rv2320c|M.tuberculosis_H37Rv ---DHLKDFVP---------------------------FGVAGIGSAAGT
MUL_1244|M.ulcerans_Agy99 ---NHLKDFAP---------------------------FGVAGVGAAAGT
MAV_4216|M.avium_104 ---ANYSPFIPKPEAGGQA-KGIDQSVLSLLTGAHTSHYGWYGVLAGASI
TH_0471|M.thermoresistible__bu ---ANYTPFIPPAEAGGEAGRSLDQSLFSLITGAEGSSYGWYGLLAGASI
Mflv_1244|M.gilvum_PYR-GCK ---PDGFAIAETLNPVGAFQ---------------PAAIAGASAGLGLFF
MAB_0950c|M.abscessus_ATCC_199 ---PQGWSWGS-LNPLNGFHDLGG----VVQGPAGPLAVAG-SAGVGLFF
MSMEG_1118|M.smegmatis_MC2_155 ---PEGISAAP-LSPA--------------------EAFAGPSVGLGLFF
MMAR_0869|M.marinum_M ---DSRSLLSLTPFTGNG---------------------GFTAITAGAAV
Mvan_2919|M.vanbaalenii_PYR-1 GAPGTGIDFSVFSFSDGD--------------------VSGSAVLAGVVA
MLBr_01974|M.leprae_Br4923 QHVNNYVTSRSAYQPTTYSLLG----------VTEIGKSTAASMTLATIV
. .
Mb2347c|M.bovis_AF2122/97 IFFSYIGLDAVSTAGDEVKDPQKTMPRALIAALVVVTGVYVLVALAAL--
Rv2320c|M.tuberculosis_H37Rv IFFSYIGLDAVSTAGDEVKDPQKTMPRALIAALVVVTGVYVLVALAAL--
MUL_1244|M.ulcerans_Agy99 IFFSFIGLDAVSTAGEEVRNPQQSVPRALIAALFVVTGVYVLVAFAAL--
MAV_4216|M.avium_104 VFFAFIGFDIVATMAEETKHPQRDVPRGILASLGIVTLLYVAVAVVLS--
TH_0471|M.thermoresistible__bu VFFAFIGFDIIATTAEETKNPQRDVARGIMATLGIVTVLYVAVSLVLT--
Mflv_1244|M.gilvum_PYR-GCK AFWSWVGFESTAMYGEESKDPKRIIPRATMIAVLGVGIFYVFVSWMAIAG
MAB_0950c|M.abscessus_ATCC_199 AFWSWVGFESSAMYAEESKNPKKIIPIAIVTSVVGVGLFYVLVSWLAIVG
MSMEG_1118|M.smegmatis_MC2_155 AFWCWMGFESTALYGEESKNPRRTVPVATFIVVIGVGLFYAFVSWMIMSG
MMAR_0869|M.marinum_M AAYSFLGFDAVSTLTEETHDAERTIPRAIVLIALIGGAIFVTVAYVVS--
Mvan_2919|M.vanbaalenii_PYR-1 AFLSWAGFEACASMGEETDDPKRNIPRALGGTLILTGVLFVVVMFAQVVG
MLBr_01974|M.leprae_Br4923 ALYAFTGFESIANAAEEMNTPDRTLPKAIPLTILTVGVIYILALVVAM--
.: *:: : :* . : :. . .: .
Mb2347c|M.bovis_AF2122/97 -GTQPWQDFAEQETAGLAIILDNVTHG--EWASTILAAGAVVSIFTVTLV
Rv2320c|M.tuberculosis_H37Rv -GTQPWQDFAEQETAGLAIILDNVTHG--EWASTILAAGAVVSIFTVTLV
MUL_1244|M.ulcerans_Agy99 -GTQPWQMFAGQEEAGLATILDNVTHS--AWASTVLAMGAVISIFTVTLV
MAV_4216|M.avium_104 -GMVSYTQLKTMPGRGQANLATAFTANGIHWASKIISIGALAGLTTVVMV
TH_0471|M.thermoresistible__bu -GMVHYTELRAAG--ENANLATAFAANGIDWAAKVISIGALAGLTTVVIV
Mflv_1244|M.gilvum_PYR-GCK TGPQQAVELAQSADTSSEIFFAPVRDTYGEWAITLFNILLVTGSFACGMA
MAB_0950c|M.abscessus_ATCC_199 TGPENAVALAQDSSTAGNIFFGPVQSHLGVWAVNLFKVLLMTGSFACGMA
MSMEG_1118|M.smegmatis_MC2_155 NGIEQTAALAAS-DSPFETVFAPTREFLGEWAVLIFRWLLLTGTFACAMA
MMAR_0869|M.marinum_M -----LVAPGSSFPDADSLSEGVARTIGGNLFAAVFLAALIIGQFTSGLA
Mvan_2919|M.vanbaalenii_PYR-1 --FGTDAAGLEAFQSSGNTLGDLGGTYIGQWFSLVIIFTAIVSAFGCHLA
MLBr_01974|M.leprae_Br4923 -------LLGSDKIVATNHTVKLAAAVGNNTFRTIIVVGALVSMFGINVA
:: : . :.
Mb2347c|M.bovis_AF2122/97 TMYGQTRILFAMGRDGLLPA---RFAKVNPRTMTPVHNTVIVAIFASTLA
Rv2320c|M.tuberculosis_H37Rv TMYGQTRILFAMGRDGLLPA---RFAKVNPRTMTPVHNTVIVAIFASTLA
MUL_1244|M.ulcerans_Agy99 TMYGQTRILFAMGRDGLLPA---RFAAVHPRFQTPVSNTVVVAIAAAVLA
MAV_4216|M.avium_104 LMLGQCRVLFAMARDGLLPR---ALAKTGSR-GTPVRITVLVALVVAVTA
TH_0471|M.thermoresistible__bu LVLGQTRVLFAMSRDGLLPR---PLSKTGPR-GTPVRITVLVGALVAIAA
Mflv_1244|M.gilvum_PYR-GCK FHNCASRYLYALGREGLSTGLQKTLGATHKTHGSPYIASFVQSGIALVLV
MAB_0950c|M.abscessus_ATCC_199 FHNCAARYLYALGRENVIPGMRKTIGSTHSTHGSPHVAGFVQTAFATVVV
MSMEG_1118|M.smegmatis_MC2_155 FHNCASRYLYALGRERILPG---VLGRTHPRYGSPWVASIVQSAFVVIVT
MMAR_0869|M.marinum_M AQAAVSRLLYAMGRDGVLPR--RVFGVVSAKFHTPMFN-IMLTGAVGMAA
Mvan_2919|M.vanbaalenii_PYR-1 TSATSGRMLYAFGRDGFGPK---ALAHIHAETGGPRRATWLVVVVALLVD
MLBr_01974|M.leprae_Br4923 ASFGAPRLWTALSDGRILPT----RLSSKNRFGVPIVAFGITAFLTLAFP
* *:. . . * : .
Mb2347c|M.bovis_AF2122/97 AFIPLDSL------ADMVSIGTLTAFSVVAVGVIVLRVR-----------
Rv2320c|M.tuberculosis_H37Rv AFIPLDSL------ADMVSIGTLTAFSVVAVGVIVLRVR-----------
MUL_1244|M.ulcerans_Agy99 ALVPLNRL------ADMVSIGTLTAFIVVSVGVIILRVR-----------
MAV_4216|M.avium_104 SVFPITKL------EEMVNVGTLFAFVLVSAGVMVLRRT-----------
TH_0471|M.thermoresistible__bu SVFPVGNL------EEMVNIGTLFAFALVSAGVIVLRRT-----------
Mflv_1244|M.gilvum_PYR-GCK LAFFFAGM------DPYIHMYTLLAILGTMAILIVQSLCAFSVVAYFHFH
MAB_0950c|M.abscessus_ATCC_199 LFFAATGR------DPYTGLYGLMALLGTTAILIVQALTAFAVISYFHVL
MSMEG_1118|M.smegmatis_MC2_155 LCYWSSGL------DPYVGQYTLSALLGTMGIIVVQALCSLAVTAYFWRY
MMAR_0869|M.marinum_M ILLSVATS------TSFINFGAFTAFTLVNVSVVVYFVR-----------
Mvan_2919|M.vanbaalenii_PYR-1 LICGATGWPDMGTGNAAINTYFLFAVAGSVCLMVCYLLVEIAAAYFVG-A
MLBr_01974|M.leprae_Br4923 LSLRFDSLN----LTGLAVIARFIQFIIVPIALFALARSR----------
: . :.
Mb2347c|M.bovis_AF2122/97 --EPDLPRGFKVPGYPVTPVLSVLACGYILAS------------------
Rv2320c|M.tuberculosis_H37Rv --EPDLPRGFKVPGYPVTPVLSVLACGYILAS------------------
MUL_1244|M.ulcerans_Agy99 --EPALPRGFWVPGYPVTPILSILACGYLLYS------------------
MAV_4216|M.avium_104 --RPDLERGFKAPWVPVLPIASIGACVWLMLN------------------
TH_0471|M.thermoresistible__bu --RPDLKRGFRVPFVPWLPLAAIAACLWLMLN------------------
Mflv_1244|M.gilvum_PYR-GCK KNHPSSAHWFKTFLAPLTGGIGMLYVVYLLWEHKESAAG-AASGTLLFKL
MAB_0950c|M.abscessus_ATCC_199 RHHPETAHWFRTLVAPLLGGLGMVYVVYLLAKHASFAAG-TASNDWVFTA
MSMEG_1118|M.smegmatis_MC2_155 PDK--RPHFLVWVVAPILGALAMIGAVLLLVLNMDAAAGGPAASTLLFRL
MMAR_0869|M.marinum_M ----ERGAGLPRWRYLVLPVIGAAVDIYLLAH------------------
Mvan_2919|M.vanbaalenii_PYR-1 PKFESVHGGTGRVAGLVLPLLGAVVIVTVLWFN------------VKDAD
MLBr_01974|M.leprae_Br4923 -TTNSVYVKRNVFTDKVLPITAVVVSAGLMVS---------------FDY
. ::
Mb2347c|M.bovis_AF2122/97 LHWYTWLAFSGWVAVAVIFYLMWGRHHSALNEEVP---------------
Rv2320c|M.tuberculosis_H37Rv LHWYTWLAFSGWVAVAVIFYLMWGRHHSALNEEVP---------------
MUL_1244|M.ulcerans_Agy99 LHWYTWIAFGGWVGIALIFYLFWGRHHSRLNAPALHDNPTGEER------
MAV_4216|M.avium_104 LTALTWVRFGIWLVVGTAIYAGYGYWHSVQGRRDAGEPDRSDALAADPNS
TH_0471|M.thermoresistible__bu LTGLTWVRFLGWMALGLVLYFFYGRHHSMLGR---GMTDISARRTG----
Mflv_1244|M.gilvum_PYR-GCK TPWIVVGVFAFGAAMALYFKFKDKRRYELIGRI-VYDDSEVRD-------
MAB_0950c|M.abscessus_ATCC_199 IPWVVAAAGIGGIALALTLKYTAPHRYDDLGRT-VLEEAHER--------
MSMEG_1118|M.smegmatis_MC2_155 IPWIVGAVFIAGCVLAVWLRKSAPQRYELIGHLDVVAPGGVENGPEGTKS
MMAR_0869|M.marinum_M LASDALIVGLSWAAIGFLYLLWLTRGLTRQPPDLAGAAERG---------
Mvan_2919|M.vanbaalenii_PYR-1 SWSAAPMLGLYWCALGLVIAVALSGIAKRVGESLAIELELVPRPTGAVEP
MLBr_01974|M.leprae_Br4923 RSIFLTRGGPNYFSISLIAITFIGIPAVAYLHYYRTSGIK----------
:.
Mb2347c|M.bovis_AF2122/97 ------
Rv2320c|M.tuberculosis_H37Rv ------
MUL_1244|M.ulcerans_Agy99 ------
MAV_4216|M.avium_104 PVP---
TH_0471|M.thermoresistible__bu ------
Mflv_1244|M.gilvum_PYR-GCK ------
MAB_0950c|M.abscessus_ATCC_199 ------
MSMEG_1118|M.smegmatis_MC2_155 FPAAMN
MMAR_0869|M.marinum_M ------
Mvan_2919|M.vanbaalenii_PYR-1 TQPA--
MLBr_01974|M.leprae_Br4923 ------