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MSSATHQLTVNGRSLRTADSHGLERDAIGSWGVFAQGLAAAAPSVAVATVPFSLFVAAGKGAAWSAVIGL VAVVLIATTISFQAKRTVSSGSLGTYAGNGLGPGAAYAAGFSLLIGYITFATTGTLGGVLYFESFLDVIG IHSEANGFKLALVALVVAFAVYLPYRGVSISAKYELIFEIIATALILIIIVASYISYGWRIDTEQWALTN LGNSTTFIAAVTAVGAYAGFESVASLGAESRDAHRTIARSLLRVVLIIGVLYILATYPQILQFRNIDGDS AILPQIATNAGVAWAIYPISLAVTIAFIVFVTAVINSAARGLFTLAHEGALPAVLTRVHPTYKTPVAGIF LIGIIATAFSVTATLSSVGRLVFDVYGNYVANWGFLVSYLLVVVATPIWLYRIKALTPARLSVSAAATVA IGYVIFSNFYPIPKFPFNILPLIFGAILLAGLLRYWYLRILRPEVAARIGSIQTLSESEKERLAELGILE VLHEEPAAEPVPEPVDTGVLVK
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4122 | - | - | 100% (512) | putative amino acid permease |
| M. abscessus ATCC 19977 | MAB_4350c | - | 4e-21 | 25.56% (450) | putative amino acid permease |
| M. abscessus ATCC 19977 | MAB_2598 | - | 4e-19 | 25.12% (406) | hypothetical protein MAB_2598 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2022c | - | 7e-18 | 25.40% (378) | integral membrane protein |
| M. gilvum PYR-GCK | Mflv_1244 | - | 9e-21 | 25.65% (386) | amino acid permease-associated region |
| M. tuberculosis H37Rv | Rv1999c | - | 8e-18 | 25.40% (378) | integral membrane protein |
| M. leprae Br4923 | MLBr_01974 | - | 7e-10 | 23.42% (363) | putative permease |
| M. marinum M | MMAR_3621 | rocE | 3e-19 | 23.12% (398) | cationic amino acid transport integral membrane protein RocE |
| M. avium 104 | MAV_2087 | - | 1e-12 | 21.23% (424) | amino acid transporter |
| M. smegmatis MC2 155 | MSMEG_4549 | - | 0.0 | 72.22% (486) | amino acid permease-associated region, putative |
| M. thermoresistible (build 8) | TH_0471 | - | 5e-15 | 21.49% (363) | POSSIBLE CATIONIC AMINO ACID TRANSPORT INTEGRAL MEMBRANE |
| M. ulcerans Agy99 | MUL_1244 | rocE | 3e-19 | 23.12% (398) | cationic amino acid transport integral membrane protein RocE |
| M. vanbaalenii PYR-1 | Mvan_0605 | - | 1e-19 | 24.30% (502) | amino acid permease-associated region |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3621|M.marinum_M --------------------------------------------------
MUL_1244|M.ulcerans_Agy99 --------------------------------------------------
MAV_2087|M.avium_104 --------------------------------------------------
TH_0471|M.thermoresistible__bu --------------------------------------------------
Mb2022c|M.bovis_AF2122/97 --------------------------------------------------
Rv1999c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4122|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_4549|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_1244|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0605|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_01974|M.leprae_Br4923 MFLSADVSCIEIVDINCSELRNDRRIPPQLALFCTNAANKAESAVTSHGQ
MMAR_3621|M.marinum_M ---------------------------MPATSIRLREQMLRRRPVGGAPV
MUL_1244|M.ulcerans_Agy99 ---------------------------MPATSIRLREQMLRRRPAGGAPV
MAV_2087|M.avium_104 -------------------------------------------------M
TH_0471|M.thermoresistible__bu ----------------------------------MTDRLRVKSVEQSIAD
Mb2022c|M.bovis_AF2122/97 --------------------------------------------MRRPLD
Rv1999c|M.tuberculosis_H37Rv --------------------------------------------MRRPLD
MAB_4122|M.abscessus_ATCC_1997 ----------------------------------MSSATHQLTVNGRSLR
MSMEG_4549|M.smegmatis_MC2_155 ---------------------------------MTTTDDPTAPVGGRALT
Mflv_1244|M.gilvum_PYR-GCK -----------------------------------MTESAERTAPGQTTP
Mvan_0605|M.vanbaalenii_PYR-1 -----------------------------------MAVRSDPPVHVAAEP
MLBr_01974|M.leprae_Br4923 LPIMANRRWAPHTRRQSGRATSTCSSLMRFSASESRAHSRFECYTLVRWS
MMAR_3621|M.marinum_M AEGAAGSLKRSFGTFELTMFGVGSTVG-TGIFFVLAEAVP-EAGPAVIVS
MUL_1244|M.ulcerans_Agy99 AEGAAGSLKRSFGTFELTMFGVGSTVG-TGIFFVLAEAVP-EAGPAVIVS
MAV_2087|M.avium_104 APGTADHLRRGIGTFQLTMFGVGSTIG-TGIFFVMSQAVP-EAGPAVIVS
TH_0471|M.thermoresistible__bu TDEPDSRLRKDLSWWDLTVFGVSVVIG-AGIFTVTASTAGNITGPAISVS
Mb2022c|M.bovis_AF2122/97 PRDIPDELRRRLGLLDAVVIGLGSMIG-AGIFAALAPAAY-AAGSGLLLG
Rv1999c|M.tuberculosis_H37Rv PRDIPDELRRRLGLLDAVVIGLGSMIG-AGIFAALAPAAY-AAGSGLLLG
MAB_4122|M.abscessus_ATCC_1997 TADSHGLERDAIGSWGVFAQGLAAAAPSVAVA-TVPFSLFVAAGKGAAWS
MSMEG_4549|M.smegmatis_MC2_155 AAESTGLERDALGPWGVFAQGLAAAAPSVAVA-VVPFALFVAAGKGAAWA
Mflv_1244|M.gilvum_PYR-GCK TASVQRLKRNAVGTFGVIFMAVATAAPITAMVGNVPIAVGFGNGSHAPAG
Mvan_0605|M.vanbaalenii_PYR-1 -AEGHTLKRGAIGLAGVVFMVVAFSAPITAMTGNLPVAVGFGNGLGTPAG
MLBr_01974|M.leprae_Br4923 IRGQGGRAISKLGFWSVVMLGINSIIG-AGIFMTPGEVIK-IAGPFAPIA
.. : ..: * .
MMAR_3621|M.marinum_M FIIAGVAAGLAAICYAELASAVPVSGSSYSYAYATLGEAVAMGVASCLLL
MUL_1244|M.ulcerans_Agy99 FIIAGVAAGLAAICCAELASAVPVSGSSYSYAYATLGEAVAMGVASCLLL
MAV_2087|M.avium_104 FLLAGVAAGLAAVCYAELASAVPVSGSSYSYAYTTLGEVVAMGVAACLLL
TH_0471|M.thermoresistible__bu FIIAAIACGLAALCYAEFASTVPVAGSAYTFSYATFGEFVAWIIGWDLIL
Mb2022c|M.bovis_AF2122/97 LAVAAVVAYCNAISSARLAARYPASGGTYVYGRMRLGDFWGYLAGWGFVV
Rv1999c|M.tuberculosis_H37Rv LAVAAVVAYCNAISSARLAARYPASGGTYVYGRMRLGDFWGYLAGWGFVV
MAB_4122|M.abscessus_ATCC_1997 AVIGLVAVVLIATTISFQAKRTVSSGSLGTYAGNGLGPGAAYAAGFSLLI
MSMEG_4549|M.smegmatis_MC2_155 AVIGLLIVVLVALTISFQARRTVSSGSLGTYTGNGLGPGFAFAAGFSLLF
Mflv_1244|M.gilvum_PYR-GCK YLVATIVLGLFAIGYATMAKHITATGAFYGYISHGLGRVMGMASGLIITL
Mvan_0605|M.vanbaalenii_PYR-1 FAIATIVLSIFSVGFIALARHITAAGAFYTFVSRGWSRIPGLPAGVMSMF
MLBr_01974|M.leprae_Br4923 YTLAGIFAAVLAIVFATAAKYVKTNGSSYAYTTAAFGHRIGIYVGVTHAI
:. : : * *. : . . . .
MMAR_3621|M.marinum_M EYGVATAAVAVGWSGYVNKLLHNVFGFQLPQALSEAPWDERPGEAAGYLN
MUL_1244|M.ulcerans_Agy99 EYGVATAAVAVGLSGYVNKLLHNVFGFQLPQALSEAPWDERPGEAAGYLN
MAV_2087|M.avium_104 EYGVATAAVSVNWSGYLNKLLSNVVGFQLPHALSAAPWDAQPG----YVN
TH_0471|M.thermoresistible__bu EFSVAAAVVAKGWSSYLG----EVFEFAG-ATTRLGPIT---------LD
Mb2022c|M.bovis_AF2122/97 GKTASCAAMALTVGFYVWP---------------------------AQAH
Rv1999c|M.tuberculosis_H37Rv GKTASCAAMALTVGFYVWP---------------------------AQAH
MAB_4122|M.abscessus_ATCC_1997 GYITFATTGTLGGVLYFESFLDVIGIHSEAN---------------GFKL
MSMEG_4549|M.smegmatis_MC2_155 GYIGFATTGTLGGVLYLDAFLESIGLGSQAI---------------WFKL
Mflv_1244|M.gilvum_PYR-GCK AYIVFEAS-LIGIFAFFFQNFLSSQLGITIH---------------WLVP
Mvan_0605|M.vanbaalenii_PYR-1 TYMTMEAG-LIGIFSVFADQAITSQFGIDLP---------------WLVY
MLBr_01974|M.leprae_Br4923 TASIAWGVLASSFVSTLLRVAFPEKIWADNDELISVKTLT------FLVF
.
MMAR_3621|M.marinum_M LPAIILIGLCALLLIRGVSESAKVNAIMVLIKLGVLGMFVILALTAYD--
MUL_1244|M.ulcerans_Agy99 LPAIILIGLCALLLIRGVSESAKVNAIMVLIKLGVLGMFVILALTAYD--
MAV_2087|M.avium_104 LPAVMLIGMCALLLIRGASESAKVNAIMVMVKLGVLVVFGILAFTAFD--
TH_0471|M.thermoresistible__bu WGALLIIGFVTVLLATGTKLSANVSLAITVIKVGVVLLVVIVGAFFIK--
Mb2022c|M.bovis_AF2122/97 AVAVAVVVALTAVNYAGIQKSAWLTRSIVAVVLVVLTAVVVAAYGSGA--
Rv1999c|M.tuberculosis_H37Rv AVAVAVVVALTAVNYAGIQKSAWLTRSIVAVVLVVLTAVVVAAYGSGA--
MAB_4122|M.abscessus_ATCC_1997 ALVALVVAFAVYLPYRGVSISAKYELIFEIIATALILIIIVASYISYG--
MSMEG_4549|M.smegmatis_MC2_155 LLVAVVVGVAVYLPYRGVSVAARYELAFELLAIASILVIIVASYIGYG--
Mflv_1244|M.gilvum_PYR-GCK ALLMLVL--NSILTYFDVNLTAKVLGVFLITEIFMLALGAVAVAVKGGGP
Mvan_0605|M.vanbaalenii_PYR-1 AMIGVVV--IATLSHWDISVAAKVLGAVLVAEIVMLTLTATASLMHH--P
MLBr_01974|M.leprae_Br4923 IAVLLAINIFGNLVIRWANGISALGKIFALSVFIAGGLWTIITQHVNN--
: : . : .
MMAR_3621|M.marinum_M --------TNHLKDFAP---------------------------FGVAGV
MUL_1244|M.ulcerans_Agy99 --------TNHLKDFAP---------------------------FGVAGV
MAV_2087|M.avium_104 --------MHHLDDFAP---------------------------FGVAGV
TH_0471|M.thermoresistible__bu --------AANYTPFIPPAEAGGEAGRSLDQSLFSLITGAEGSSYGWYGL
Mb2022c|M.bovis_AF2122/97 --------ADPARLDIG-------------------------VDAHVWGM
Rv1999c|M.tuberculosis_H37Rv --------ADPARLDIG-------------------------VDAHVWGM
MAB_4122|M.abscessus_ATCC_1997 -------WRIDTEQWAL-------------------------TNLGNSTT
MSMEG_4549|M.smegmatis_MC2_155 -------FRIDWEQWKP-------------------------QHLGSSAT
Mflv_1244|M.gilvum_PYR-GCK DGFAIAETLNPVGAFQP-------------------------AAIAGASA
Mvan_0605|M.vanbaalenii_PYR-1 EGMSWTS-LNPATALST-------------------------NGVAGGVV
MLBr_01974|M.leprae_Br4923 -------YVTSRSAYQPTTYSLLG--------------VTEIGKSTAASM
MMAR_3621|M.marinum_M GAAAGTIFFSFIGLDAVSTAGEEVRNPQQSVPRALIAALFVVTGVYVLVA
MUL_1244|M.ulcerans_Agy99 GAAAGTIFFSFIGLDAVSTAGEEVRNPQQSVPRALIAALFVVTGVYVLVA
MAV_2087|M.avium_104 GTAAGTIFFSYIGLDAVSTAGDEVTNPQKTMPRALIAALLTVTGVYVFVA
TH_0471|M.thermoresistible__bu LAGASIVFFAFIGFDIIATTAEETKNPQRDVARGIMATLGIVTVLYVAVS
Mb2022c|M.bovis_AF2122/97 LQAAGLLFFAFAGYARIATLGEEVRDPARTIPRAIPLALGITLAVYALVA
Rv1999c|M.tuberculosis_H37Rv LQAAGLLFFAFAGYARIATLGEEVRDPARTIPRAIPLALGITLAVYALVA
MAB_4122|M.abscessus_ATCC_1997 FIAAVTAVGAYAGFESVASLGAESRDAHRTIARSLLRVVLIIGVLYILAT
MSMEG_4549|M.smegmatis_MC2_155 FIAAVTAVGSYAGFESVASLGAEAKNAHRNIARSLLRVVILLGVLYIFAT
Mflv_1244|M.gilvum_PYR-GCK GLGLFFAFWSWVGFESTAMYGEESKDPKRIIPRATMIAVLGVGIFYVFVS
Mvan_0605|M.vanbaalenii_PYR-1 GLGLLMAFWSWVGFESTAIYGEESKNPKKIVPQATMIAVIGIGVFYTFIA
MLBr_01974|M.leprae_Br4923 TLATIVALYAFTGFESIANAAEEMNTPDRTLPKAIPLTILTVGVIYILAL
. . :: * : . * . : :.:. .: .*
MMAR_3621|M.marinum_M FAALGTQPWQMFAGQ-----EEAGLATILDNVTHSAWASTVLAMGAVISI
MUL_1244|M.ulcerans_Agy99 FAALGTQPWQMFAGQ-----EEAGLATILDNVTHSAWASTVLAMGAVISI
MAV_2087|M.avium_104 LAALGTQPWQDFGGQ-----QEAGLATILDHVTHGSWASTILAAGAVISI
TH_0471|M.thermoresistible__bu LVLTGMVHYTELRAAG----ENANLATAFA-ANGIDWAAKVISIGALAGL
Mb2022c|M.bovis_AF2122/97 VAVIAVLGPQRLARA-------AAPLSEAMRVAGVNWLIPVVQIGAAVAA
Rv1999c|M.tuberculosis_H37Rv VAVIAVLGPQRLARA-------AAPLSEAMRVAGVNWLIPVVQIGAAVAA
MAB_4122|M.abscessus_ATCC_1997 YPQILQFR---------NIDGDSAILPQIATNAGVAWAIYPISLAVTIAF
MSMEG_4549|M.smegmatis_MC2_155 YPQILHFD---------DIDGDKAVLPQLADSVGVAWVNQVVSGAVAIAF
Mflv_1244|M.gilvum_PYR-GCK WMAIAGTGPQQAVELAQSADTSSEIFFAPVRDTYGEWAITLFNILLVTGS
Mvan_0605|M.vanbaalenii_PYR-1 WGMIVGNGPTKAVELS-SGPTPFDLIYAPTQQYLGQWAIVVFEWLMVGGS
MLBr_01974|M.leprae_Br4923 VVAMLLGSDKIVATN---------HTVKLAAAVGNNTFRTIIVVGALVSM
. .
MMAR_3621|M.marinum_M FTVTLVTMYGQTRILFAMGRDGL---LPARFAAVHPRFQTPVSNTVVVAI
MUL_1244|M.ulcerans_Agy99 FTVTLVTMYGQTRILFAMGRDGL---LPARFAAVHPRFQTPVSNTVVVAI
MAV_2087|M.avium_104 FSVTLVTMYGITRILFAMGRDGL---LPPRFARVNPRTMTPVNNTVIVAV
TH_0471|M.thermoresistible__bu TTVVIVLVLGQTRVLFAMSRDGL---LPRPLSKTGPR-GTPVRITVLVGA
Mb2022c|M.bovis_AF2122/97 LGSLLALILGVSRTTLAMARDRH---LPRWLAAVHPRFKVPFRAELVVGA
Rv1999c|M.tuberculosis_H37Rv LGSLLALILGVSRTTLAMARDRH---LPRWLAAVHPRFKVPFRAELVVGA
MAB_4122|M.abscessus_ATCC_1997 IVFVTAVINSAARGLFTLAHEGA---LPAVLTRVHPTYKTPVAGIFLIGI
MSMEG_4549|M.smegmatis_MC2_155 IVFVTAVTTAAARSLFTFAHEGA---LPRVFTKVHEEHKTPWAGVVFVGI
Mflv_1244|M.gilvum_PYR-GCK FACGMAFHNCASRYLYALGREGLSTGLQKTLGATHKTHGSPYIASFVQSG
Mvan_0605|M.vanbaalenii_PYR-1 FACALAIHNSAARYLFAFGRDGL---LPRRLGAAHPKHASPYVASLAQSV
MLBr_01974|M.leprae_Br4923 FGINVAASFGAPRLWTALSDGRI---LPTRLS-SKNRFGVPIVAFGITAF
. .* ::. * : * .
MMAR_3621|M.marinum_M AAAVLAALVPLNRLA----------DMVSIGTLTAFIVVSVGVIILRVRE
MUL_1244|M.ulcerans_Agy99 AAAVLAALVPLNRLA----------DMVSIGTLTAFIVVSVGVIILRVRE
MAV_2087|M.avium_104 AAATLAAFIPLQNLA----------DMVSIGTLTAFVVVSVGVIVLRVRE
TH_0471|M.thermoresistible__bu LVAIAASVFPVGNLE----------EMVNIGTLFAFALVSAGVIVLRRTR
Mb2022c|M.bovis_AF2122/97 VVAALAATADIRGAI----------GFSSFGVLVYYAIANASALTLGLDE
Rv1999c|M.tuberculosis_H37Rv VVAALAATADIRGAI----------GFSSFGVLVYYAIANASALTLGLDE
MAB_4122|M.abscessus_ATCC_1997 IATAFSVTATLSSVG-RLVFDVYGNYVANWGFLVSYLLVVVATPIWLYRI
MSMEG_4549|M.smegmatis_MC2_155 VAYVFSVAATFSSAG-RLVFDVYGGYVANWGFLTSYLLVVIATPIWLRKI
Mflv_1244|M.gilvum_PYR-GCK IALVLVLAFFFAGMDPYIHMYTLLAILGTMAILIVQSLCAFSVVAYFHFH
Mvan_0605|M.vanbaalenii_PYR-1 FAAVVLIVCAISGSDPYAVLFVLVAILATLCLLTVQTMSSIATVVYFHVK
MLBr_01974|M.leprae_Br4923 LTLAFPLSLRFDSLN--------LTGLAVIARFIQFIIVPIALFALARSR
. . . : : .
MMAR_3621|M.marinum_M PA--LPRGFWVPGYPVTPILSILACGYLLYSLHWYT--------------
MUL_1244|M.ulcerans_Agy99 PA--LPRGFWVPGYPVTPILSILACGYLLYSLHWYT--------------
MAV_2087|M.avium_104 PD--LPRGFRVPGYPVTPVLSIMACGYILASLHWYT--------------
TH_0471|M.thermoresistible__bu PD--LKRGFRVPFVPWLPLAAIAACLWLMLNLTGLT--------------
Mb2022c|M.bovis_AF2122/97 GR--PRR--------LIPLVGLIGCVVLAFALPLSS--------------
Rv1999c|M.tuberculosis_H37Rv GR--PRR--------LIPLVGLIGCVVLAFALPLSS--------------
MAB_4122|M.abscessus_ATCC_1997 KA--LTP-----ARLSVSAAATVAIGYVIFSNFYPIPKFP--------FN
MSMEG_4549|M.smegmatis_MC2_155 NA--LTP-----WHLVVSIAATVGLGYVIVSNFYPVPEFP--------FN
Mflv_1244|M.gilvum_PYR-GCK KN--HPSSAHWFKTFLAPLTGGIGMLYVVYLLWEHKESAAGAASGTLLFK
Mvan_0605|M.vanbaalenii_PYR-1 KQ--HPETANWWRTLAAPVIGGAGMVYVIYLMASNMSAAAGTASESLFFK
MLBr_01974|M.leprae_Br4923 TTNSVYVKRNVFTDKVLPITAVVVSAGLMVSFDYRS--------------
. . :
MMAR_3621|M.marinum_M --WIAFGGWVGIALIFYLFWGRHHSRLNAPALHDNPTGEER---------
MUL_1244|M.ulcerans_Agy99 --WIAFGGWVGIALIFYLFWGRHHSRLNAPALHDNPTGEER---------
MAV_2087|M.avium_104 --WIAFSGWVLLALIFYFVWGRHHSALNDAAVD--PSGQER---------
TH_0471|M.thermoresistible__bu --WVRFLGWMALGLVLYFFYGRHHSMLGRGMTDISARRTG----------
Mb2022c|M.bovis_AF2122/97 --VAAGAAVLGVGVAAYGVRRIITRRARQTDSGDTQRSGHPSAT------
Rv1999c|M.tuberculosis_H37Rv --VAAGAAVLGVGVAAYGVRRIITRRARQTDSGDTQRSGHPSAT------
MAB_4122|M.abscessus_ATCC_1997 ILPLIFGAILLAGLLRYWYLRILRPEVAARIGSIQTLSESEKERLAELGI
MSMEG_4549|M.smegmatis_MC2_155 ILPFVFGVILLAGLAWYWYLKRTRPEIAQRIGTIQTLSEEEQRRLADEGI
Mflv_1244|M.gilvum_PYR-GCK LTPWIVVGVFAFGAAMALYFKFKDKRRYELIGRIVYDDSEVRD-------
Mvan_0605|M.vanbaalenii_PYR-1 MIPYILLTLLFGSIAVALYLRKARPDLYARIGSTVFDDKPTD--------
MLBr_01974|M.leprae_Br4923 ----IFLTRGGPNYFSISLIAITFIGIPAVAYLHYYRTSGIK--------
MMAR_3621|M.marinum_M ------------------------
MUL_1244|M.ulcerans_Agy99 ------------------------
MAV_2087|M.avium_104 ------------------------
TH_0471|M.thermoresistible__bu ------------------------
Mb2022c|M.bovis_AF2122/97 ------------------------
Rv1999c|M.tuberculosis_H37Rv ------------------------
MAB_4122|M.abscessus_ATCC_1997 LEVLHEEPAAEPVPEPVDTGVLVK
MSMEG_4549|M.smegmatis_MC2_155 VDVLDGEGGGAR------------
Mflv_1244|M.gilvum_PYR-GCK ------------------------
Mvan_0605|M.vanbaalenii_PYR-1 ------------------------
MLBr_01974|M.leprae_Br4923 ------------------------