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M. smegmatis MC2 155 MSMEG_4547 (-)

annotation: acyl-CoA dehydrogenase family protein
coordinates: 4637637 - 4638872
length: 411

STDSFYLKRPTGYDAELRSVFRPIFARIAEGNVGRERNRILPHEQVRWLNEAGFGTLRIPAEQGGFGASL
EQTFQLLAELGQADANVAHIWRNHLAFVEDRLNAPVTEENNTWIKRFLAGEFVGGGWTEANNGTLANIAT
TITARDDHWLVSGAKYYATGSLYADWLDVIGRGDDGELWTALVRSDDPGVKLVDDWRGFGQRATASGSVH
YDNARAERGNVFPAVERFAYQPHFYQIAMLAVLTGITKAVQRDGSAALKQRKRNYPQGLSEVPSDDAQLL
QVIGEVSAEAFGAEAALALSARTLDRVVAGRLAGSEDRARQLLIDAEVAVTQAQLVIIGAALRSTTKVFD
ALGASAVSEELGLDRHWRNARTLASHNPVVYKARILGDWFINGKDPVPDLASRGRGGQGN*

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. smegmatis MC2 155 MSMEG_4547 - - 100% (411) acyl-CoA dehydrogenase family protein
M. smegmatis MC2 155 MSMEG_4084 - 1e-64 37.34% (383) putative acyl-CoA dehydrogenase
M. smegmatis MC2 155 MSMEG_4097 - 1e-60 37.25% (400) acyl-CoA dehydrogenase domain-containing protein

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb3302c fadE25 2e-10 27.52% (218) acyl-CoA dehydrogenase FADE25
M. gilvum PYR-GCK Mflv_4943 - 2e-14 25.34% (371) acyl-CoA dehydrogenase domain-containing protein
M. tuberculosis H37Rv Rv3274c fadE25 2e-10 27.52% (218) acyl-CoA dehydrogenase FADE25
M. leprae Br4923 MLBr_00737 fadE25 1e-07 24.29% (210) putative acyl-CoA dehydrogenase
M. abscessus ATCC 19977 MAB_1422c - 4e-68 37.92% (385) putative acyl-CoA dehydrogenase
M. marinum M MMAR_3847 fadE19 1e-11 24.73% (372) acyl-CoA dehydrogenase FadE19
M. avium 104 MAV_3422 - 8e-54 34.71% (363) acyl-CoA dehydrogenase domain-containing protein
M. thermoresistible (build 8) TH_3721 - 9e-59 42.71% (288) PUTATIVE putative acyl-CoA dehydrogenase family protein
M. ulcerans Agy99 MUL_3778 fadE19 9e-11 23.66% (372) acyl-CoA dehydrogenase FadE19
M. vanbaalenii PYR-1 Mvan_3173 - 9e-39 28.72% (383) acyl-CoA dehydrogenase type 2

CLUSTAL 2.0.9 multiple sequence alignment


MSMEG_4547|M.smegmatis_MC2_155      ----MSTDSFYLKRPTGYDAELRSVFRPIFARIAEGNVGRERN--RILPH
TH_3721|M.thermoresistible__bu      ------VPYFDEQR----FEALAAEFRPVFDRIRAGAVQRERD--RELPF
MAB_1422c|M.abscessus_ATCC_199      -------MTSAPSVLEIRALPGTDTYRNLLAQVAEGARDRDLD--DENPF
MAV_3422|M.avium_104                -------MPVAFHRQDT--PAGAAAVQPVLAEIAADYRLRLADGGTEPPL
Mb3302c|M.bovis_AF2122/97           MVGWAGNPSFDLFKLPEEHDEMRSAIRALAEKEIAPHAAEVDEK-ARFPE
Rv3274c|M.tuberculosis_H37Rv        MVGWAGNPSFDLFKLPEEHDEMRSAIRALAEKEIAPHAAEVDEK-ARFPE
MLBr_00737|M.leprae_Br4923          MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQR-ARFPE
Mflv_4943|M.gilvum_PYR-GCK          -------MPVDRLLPTDDARDLVELARQIADKVLDPIVDRHEKD-ETYPE
MMAR_3847|M.marinum_M               -----MTTAISAGTLPKEYQDLRDTVADFARSVVAPVSAKHDEE-HSFPY
MUL_3778|M.ulcerans_Agy99           -----MTTAISAGTLPKEYQDLRDTVADFARSVVAPVSAKHDEE-HSFPY
Mvan_3173|M.vanbaalenii_PYR-1       --MATDITDRIPDTLLRTPADALAAAEEVAEAIAAGSAERERAG--AVLT
                                                                .                     

MSMEG_4547|M.smegmatis_MC2_155      EQVRWLNEAGFGTLRIPAEQGGFGASLEQTFQLLAELGQADANVAHIWRN
TH_3721|M.thermoresistible__bu      EQIGWLKAAGFGAVRLPVSAGGRGATIPELTRLLIELSTADSNITQALRG
MAB_1422c|M.abscessus_ATCC_199      DQVRLLKEAGFGRLRIPTELGGAGLSVRQLFSAIIDVAQADPIVAHIFRT
MAV_3422|M.avium_104                RGLKLVRDHRLGALRLARELGGAGYTAPEFFDYLVALAAADPDLAHILRI
Mb3302c|M.bovis_AF2122/97           EALVALNSSGFNAVHIPEEYGGQGADSVATCIVIEEVARVDASASLIPAV
Rv3274c|M.tuberculosis_H37Rv        EALVALNSSGFNAVHIPEEYGGQGADSVATCIVIEEVARVDASASLIPAV
MLBr_00737|M.leprae_Br4923          EALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVDASASLIPAV
Mflv_4943|M.gilvum_PYR-GCK          GVFATLGEAGLLSLPYPEEWGGGGQPYEVYLQVLEELAARWAAVAVAVSV
MMAR_3847|M.marinum_M               EVVAKMGEMGLFGLPFPEEYGGMGGDYFALALALEELGKVDQSVAITLEA
MUL_3778|M.ulcerans_Agy99           EVVAKMGEMGLFGLPFPEEYGGMGGDYFALALALEELGKVNQSVAITLEA
Mvan_3173|M.vanbaalenii_PYR-1       PQLRLVAESGLLGISVPTAHGGPGLPASTVVEVLRRLARADGAVGQLLLS
                                      .  :    :  :  .   ** *         :  :.            

MSMEG_4547|M.smegmatis_MC2_155      HLAFVEDRLNAPVTEE-NNTWIKRFLAGEFVGGGWTEANNGTLANIATTI
TH_3721|M.thermoresistible__bu      HFAFAEDRLVAAPGPG-RDRWWQRFAAGDLAGNAWTEIGDVVLGEANTKV
MAB_1422c|M.abscessus_ATCC_199      HFWFVEERLRTLADPV-SAAWLTKVNEGNLFANAFSEKGSLAVGSLVFNT
MAV_3422|M.avium_104                HYALVEELQVTPRRPG-SDRWIAVVAEGGLIGGANAEQSQKSVGGNHRDT
Mb3302c|M.bovis_AF2122/97           NK-LGTMGLILRGSEELKKQVLPALAAEGAMASYALSEREAGSDAASMRT
Rv3274c|M.tuberculosis_H37Rv        NK-LGTMGLILRGSEELKKQVLPALAAEGAMASYALSEREAGSDAASMRT
MLBr_00737|M.leprae_Br4923          NK-LGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAGSDAASMRT
Mflv_4943|M.gilvum_PYR-GCK          HS-LSCHPLMSFGSDEQRQRWLPDMLGGSTIGAYSLSEPQAGSDAAALTC
MMAR_3847|M.marinum_M               GVGLGAMPIYRFGNEEQKSKWLPDLLAGRALAGFGLTEPGAGSDAGSTRT
MUL_3778|M.ulcerans_Agy99           GVGLGAMPIYRFGNEEQKSKWLPDLLAGRALAGFGLTEPGAGSDAGSTRT
Mvan_3173|M.vanbaalenii_PYR-1       HF-VVAQAISGLGHTQPAPRIYADLLAGAQLGNASAERG--TAHALDRRT
                                       .                    .      .                  

MSMEG_4547|M.smegmatis_MC2_155      TARDD--HWLVSGAKYYATGSL--YADWLDVIG-RGDD----GELWTALV
TH_3721|M.thermoresistible__bu      APSGDPGTFVVNGQKFYSTGSI--FADWIDLYAQRTDT----GEFVIAAV
MAB_1422c|M.abscessus_ATCC_199      RLLPVGDAYRLNGEKFYSTGTL--FADYLTVTA-TTDR----DSVASVIV
MAV_3422|M.avium_104                RLVTTPDGLRLRGRKFYSTGAQ--FSDYLRITA-QDDD----GAPTAVVI
Mb3302c|M.bovis_AF2122/97           RAKADGDHWILNGAKCWITNGG--KSTWYTVMAVTDPD-RGANGISAFMV
Rv3274c|M.tuberculosis_H37Rv        RAKADGDHWILNGAKCWITNGG--KSTWYTVMAVTDPD-RGANGISAFMV
MLBr_00737|M.leprae_Br4923          RAKADGDDWILNGFKCWITNGG--KSTWYTVMAVTDPD-KGANGISAFIV
Mflv_4943|M.gilvum_PYR-GCK          RATAVDGGYRITGSKAWITHGG--IADFYNLFARTG---EGSQGISCFLV
MMAR_3847|M.marinum_M               TARLDGGEWVVNGSKQFITNSGTDITSLVTITAVTGSIADGKKEISTIIV
MUL_3778|M.ulcerans_Agy99           TARLDGGEWVVNGSKQFITNSGTDITSLVTITAVTGSIADGKKEISTIIV
Mvan_3173|M.vanbaalenii_PYR-1       TVTRRDGHWVLNGTKYYATGTLG--ATWIAVAARIEGR--ENGDTATAFV
                                              : * * : *      :    : .                :

MSMEG_4547|M.smegmatis_MC2_155      RSDDPGVKLVDD-WRGFGQRATASGSVHYDNARAERGNVFPAV-------
TH_3721|M.thermoresistible__bu      DAHADGVTHADD-WDGFGQRTTGSGTSTYRDVRVPAENLIPFA-------
MAB_1422c|M.abscessus_ATCC_199      PGDRDGVRLVDD-WDGFGQRRTGTGTTIFSQVDVAADEILSETPY--DAA
MAV_3422|M.avium_104                PVDRAGVEHLDD-WDGIGQRQTGSGTTVFNDVAVADDEVFPLG----STI
Mb3302c|M.bovis_AF2122/97           HKDDEGFTVGPK-ERKLGIKGSPTTELYFENCRIPGDRIIGEPG---TGF
Rv3274c|M.tuberculosis_H37Rv        HKDDEGFTVGPK-ERKLGIKGSPTTELYFENCRIPGDRIIGEPG---TGF
MLBr_00737|M.leprae_Br4923          HKDDEGFSIGPK-EKKLGIKGSPTTELYFDKCRIPGDRIIGEPG---TGF
Mflv_4943|M.gilvum_PYR-GCK          PRDTEGLTFGKP-EEKMGLHAVPTTAAHYDDANLDSDRRIGTEG---QGL
MMAR_3847|M.marinum_M               PSGTPGFIVEPV-YNKVGWNASDTHPLSFDDARVPEENLLGIRG---KGY
MUL_3778|M.ulcerans_Agy99           PSGTPGFIVEPV-YNKVGWNASDTHPLSFDDARVPEENLLGIRG---KGY
Mvan_3173|M.vanbaalenii_PYR-1       RPDQEGVTLDLESWSAFGQRGTASGEVRLNNVVVDDDLLIDEGPPPDPIT
                                         *.         .* .   :      .        :          

MSMEG_4547|M.smegmatis_MC2_155      ERFAYQPHFYQIAMLAVLTGITKAVQRDGSAALKQRKRNYPQGLSEVPS-
TH_3721|M.thermoresistible__bu      TRFRYQTAFYQLFHLATLAGIAHAATAELAQRVRGRTRTFSHGNAPRYA-
MAB_1422c|M.abscessus_ATCC_199      PVPTTQYASLQLYILAIVAGVLRAVVDDGEALLRSRQRNFSHALTERPV-
MAV_3422|M.avium_104                GVNRARGALVQLYLHAVAAGILRSLTEDAAALVRGRRRTYTFASADTPT-
Mb3302c|M.bovis_AF2122/97           KTALATLDHTRPTIGAQAVGIAQGALDAAIAYTKDRKQ-----FGESIS-
Rv3274c|M.tuberculosis_H37Rv        KTALATLDHTRPTIGAQAVGIAQGALDAAIAYTKDRKQ-----FGESIS-
MLBr_00737|M.leprae_Br4923          KTALATLDHTRPTIGAQAVGIAQGALDAAIVYTKDRKQ-----FGESIS-
Mflv_4943|M.gilvum_PYR-GCK          QIAFSALDSGRLGIAAVAVGLAQAALDEAVAYSQERTT-----FGRKII-
MMAR_3847|M.marinum_M               ANFLSILDEGRIAIAALATGVAQGCVDESVKYAKERQS-----FGQPIG-
MUL_3778|M.ulcerans_Agy99           ANFLSILDEGRIAIAALATGVAQGCVDESVKYAKERQS-----FGQPIG-
Mvan_3173|M.vanbaalenii_PYR-1       ADPSVLGAFDQALHAAIDIGIARAALEDGAVFVRTRSRPWKEALDAGIER
                                              :    *   *: :.         : *              

MSMEG_4547|M.smegmatis_MC2_155      --DDAQLLQVIGEVSAEAFGAEAALALSARTLDRVVAGRLAGSEDRARQL
TH_3721|M.thermoresistible__bu      --ADPQIQQVVGEVMAAAFAAEAIALRAAEDXX--XRRRSSAAPPRRR--
MAB_1422c|M.abscessus_ATCC_199      --DDPLLQRTLGELSATAFAAEATVLAAADAIEAATATLRDGVPDAQLAQ
MAV_3422|M.avium_104                --ADPQLLQIVGEIDAVAYTAHALVRNAAAELAPALQAARDTGIDPELEA
Mb3302c|M.bovis_AF2122/97           --TFQAVQFMLADMAMKVEAARLMVYSAAARAERGEPDLGFISAASKCFA
Rv3274c|M.tuberculosis_H37Rv        --TFQAVQFMLADMAMKVEAARLMVYSAAARAERGEPDLGFISAASKCFA
MLBr_00737|M.leprae_Br4923          --TFQSIQFMLADMAMKVEAARLIVYAAAARAERGEPDLGFISAASKCFA
Mflv_4943|M.gilvum_PYR-GCK          --DHQGLAFLLADMAAAVDSARATYLDAARRRDAGLP-YSRHASVAKLVA
MMAR_3847|M.marinum_M               --SYQAISFKIARMEARAHVARTAYYEAAAKMLAGKP-FKKEAAIAKMIS
MUL_3778|M.ulcerans_Agy99           --SYQAISFKIARMEARAHVARTAYYEAAAKMLAGKP-FKKEAAIAKMIS
Mvan_3173|M.vanbaalenii_PYR-1       ADQEPHVVRRFGELTARLYALEALLARGTALIDEAYAAPEVTRDAAAQAS
                                          :   .. :       .     .:                     

MSMEG_4547|M.smegmatis_MC2_155      LIDAEVAVTQAQLVIIGAALRSTTKVFDALGASAVSEELGLDRHWRNART
TH_3721|M.thermoresistible__bu      --------------------TRPRSCWDATRSSSVCVPR--------SRP
MAB_1422c|M.abscessus_ATCC_199      EAQ--VAVAKAKVHIDAVALDAATKLLDLGGASAASRTRNLDRHWRNIRT
MAV_3422|M.avium_104                AAS--IAAARVKVAIQEPALRAASRVFDAGGASAVQASALLDRHWRNLRT
Mb3302c|M.bovis_AF2122/97           S---------------DVAMEVTTDAVQLFGGAGYTTDFPVERFMRDAKI
Rv3274c|M.tuberculosis_H37Rv        S---------------DVAMEVTTDAVQLFGGAGYTTDFPVERFMRDAKI
MLBr_00737|M.leprae_Br4923          S---------------DIAMEVTTDAVQLFGGAGYTSDFPVERFMRDAKI
Mflv_4943|M.gilvum_PYR-GCK          T---------------DAAMKVTTDAVQVLGGAGYTRDYRVERYMREAKI
MMAR_3847|M.marinum_M               S---------------EAAMDNARDATQVHGGYGFMNEYPVARHYRDSKI
MUL_3778|M.ulcerans_Agy99           S---------------EAAMDNARDAAQVHGGYGFMNEYPVARHYRDSKI
Mvan_3173|M.vanbaalenii_PYR-1       LT-----VAAAKALAQQDAVEIAGAIFELTGTSGTDGAVNLDRHWRNVRV
                                                          .    :     .              : 

MSMEG_4547|M.smegmatis_MC2_155      LASHNPVVYKARILGDWFINGKDPVPDLASRGRGGQGN
TH_3721|M.thermoresistible__bu      PRCTSPWAPRP-------MSG-----------------
MAB_1422c|M.abscessus_ATCC_199      ISLHNPVHYKARVIGQNLLHGTPLPANAYF--------
MAV_3422|M.avium_104                LFSHNPTVYKARVLGDVVVNGAALPDTSFF--------
Mb3302c|M.bovis_AF2122/97           TQIYEGTNQIQRVVMSRALLR-----------------
Rv3274c|M.tuberculosis_H37Rv        TQIYEGTNQIQRVVMSRALLR-----------------
MLBr_00737|M.leprae_Br4923          TQIYEGTNQIQRVVMSRALLR-----------------
Mflv_4943|M.gilvum_PYR-GCK          TQIFEGTNQIQRLVISRHLTRG----------------
MMAR_3847|M.marinum_M               LEIGEGTTEVQLMLIARSLGLS----------------
MUL_3778|M.ulcerans_Agy99           LEIGEGTTEVQLMLIARSLGLS----------------
Mvan_3173|M.vanbaalenii_PYR-1       HSLHDPARWKYVHLGNHTLHDTRPPRLGLIL-------
                                        .             :

species	id	gene	e-value	identity (len)	annotation
M. smegmatis MC2 155	MSMEG_4547	-	-	100% (411)	acyl-CoA dehydrogenase family protein
M. smegmatis MC2 155	MSMEG_4084	-	1e-64	37.34% (383)	putative acyl-CoA dehydrogenase
M. smegmatis MC2 155	MSMEG_4097	-	1e-60	37.25% (400)	acyl-CoA dehydrogenase domain-containing protein