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MPVDRLLPTDDARDLVELARQIADKVLDPIVDRHEKDETYPEGVFATLGEAGLLSLPYPEEWGGGGQPYE VYLQVLEELAARWAAVAVAVSVHSLSCHPLMSFGSDEQRQRWLPDMLGGSTIGAYSLSEPQAGSDAAALT CRATAVDGGYRITGSKAWITHGGIADFYNLFARTGEGSQGISCFLVPRDTEGLTFGKPEEKMGLHAVPTT AAHYDDANLDSDRRIGTEGQGLQIAFSALDSGRLGIAAVAVGLAQAALDEAVAYSQERTTFGRKIIDHQG LAFLLADMAAAVDSARATYLDAARRRDAGLPYSRHASVAKLVATDAAMKVTTDAVQVLGGAGYTRDYRVE RYMREAKITQIFEGTNQIQRLVISRHLTRG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4943 | - | - | 100% (380) | acyl-CoA dehydrogenase domain-containing protein |
| M. gilvum PYR-GCK | Mflv_4743 | - | 9e-74 | 41.29% (373) | butyryl-CoA dehydrogenase |
| M. gilvum PYR-GCK | Mflv_2554 | - | 1e-67 | 38.07% (373) | acyl-CoA dehydrogenase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3302c | fadE25 | 2e-74 | 42.42% (363) | acyl-CoA dehydrogenase FADE25 |
| M. tuberculosis H37Rv | Rv3274c | fadE25 | 2e-74 | 42.42% (363) | acyl-CoA dehydrogenase FADE25 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 2e-74 | 41.55% (373) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3618c | - | 3e-72 | 42.11% (361) | acyl-CoA dehydrogenase FadE |
| M. marinum M | MMAR_1262 | fadE25 | 4e-75 | 41.55% (373) | acyl-CoA dehydrogenase FadE25 |
| M. avium 104 | MAV_2668 | - | 0.0 | 87.00% (377) | acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0108 | - | 1e-180 | 83.02% (377) | acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_4603 | - | 0.0 | 82.59% (379) | PUTATIVE acyl-CoA dehydrogenase domain protein |
| M. ulcerans Agy99 | MUL_2626 | fadE25 | 1e-75 | 42.09% (373) | acyl-CoA dehydrogenase FadE25 |
| M. vanbaalenii PYR-1 | Mvan_1476 | - | 0.0 | 92.88% (379) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1262|M.marinum_M MAGWAGNPSFDLFQLPEEHQELRAAIRALAEKEIAPHAADVDENSRFPQE
MUL_2626|M.ulcerans_Agy99 MAGWAGNPSFDLFQLPEEHQELRAAIRALAEKEIAPHAADVDENSRFPQE
Mb3302c|M.bovis_AF2122/97 MVGWAGNPSFDLFKLPEEHDEMRSAIRALAEKEIAPHAAEVDEKARFPEE
Rv3274c|M.tuberculosis_H37Rv MVGWAGNPSFDLFKLPEEHDEMRSAIRALAEKEIAPHAAEVDEKARFPEE
MLBr_00737|M.leprae_Br4923 MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQRARFPEE
MAB_3618c|M.abscessus_ATCC_199 ---MAGNPSFDLFKLGEEHDELRAAIRGLAEKEIAPHAKDVDEKARFPQE
Mflv_4943|M.gilvum_PYR-GCK -------MPVDRLLPTDDARDLVELARQIADKVLDPIVDRHEKDETYPEG
Mvan_1476|M.vanbaalenii_PYR-1 -------MAVDRLLPTDEARELVDLARQIADKALDPIVDQHEKDETYPDG
MAV_2668|M.avium_104 -------MTVDRLLPTPEARELVRLAADVADKVLDPIVDEHEKNETYPEG
MSMEG_0108|M.smegmatis_MC2_155 -------MSVDRLLPSEEARDLIALTREVADKVLDPIVDEHERNETYPEG
TH_4603|M.thermoresistible__bu -------MAVDRLLPSQEAAELIELTREIADKVLDPIVDRHEKDETYPEG
.* : : :: :*:* : * . :. :*:
MMAR_1262|M.marinum_M ALDALNASGFNAVHVPEEYGGQGADSVAACIVIEEVARVDASASLIPAVN
MUL_2626|M.ulcerans_Agy99 ALDALNASGFNALHVPEEYGGQGADSVAACIVIEEVARVDASASLIPAVN
Mb3302c|M.bovis_AF2122/97 ALVALNSSGFNAVHIPEEYGGQGADSVATCIVIEEVARVDASASLIPAVN
Rv3274c|M.tuberculosis_H37Rv ALVALNSSGFNAVHIPEEYGGQGADSVATCIVIEEVARVDASASLIPAVN
MLBr_00737|M.leprae_Br4923 ALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVDASASLIPAVN
MAB_3618c|M.abscessus_ATCC_199 ALDALVASGFNAVHVPEEYDGQGADSVAACIVIEEVARVCASSSLIPAVN
Mflv_4943|M.gilvum_PYR-GCK VFATLGEAGLLSLPYPEEWGGGGQPYEVYLQVLEELAARWAAVAVAVSVH
Mvan_1476|M.vanbaalenii_PYR-1 VFATLGEAGLLSLPYPEEWGGGGQPYEVYLQVLEELAARWAAVAVAVSVH
MAV_2668|M.avium_104 VFATLGETGLLTLPHPEQWGGGGQPYEVYLQVLEELAARWAAVAVAVSVH
MSMEG_0108|M.smegmatis_MC2_155 VFAQLGAAGLLSLPQPEQWGGGGQPYEVYLQVLEEIAARWAAVAVAVSVH
TH_4603|M.thermoresistible__bu VFEQLGAAGLLSLPQPEEWGGGGQPYEVYLQVLEEIAARWASVAVAVSVH
.: * :*: :: **::.* * . *:**:* *: :: :*:
MMAR_1262|M.marinum_M KLGTMGLILRGSDDLKKQVLPSLADGAAMASYALSEREAGSDAGAMRTRA
MUL_2626|M.ulcerans_Agy99 KLGTMGLILRGSDELKKQVLPSLADGAAMASYALSEREAGSDAGAMRTRA
Mb3302c|M.bovis_AF2122/97 KLGTMGLILRGSEELKKQVLPALAAEGAMASYALSEREAGSDAASMRTRA
Rv3274c|M.tuberculosis_H37Rv KLGTMGLILRGSEELKKQVLPALAAEGAMASYALSEREAGSDAASMRTRA
MLBr_00737|M.leprae_Br4923 KLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAGSDAASMRTRA
MAB_3618c|M.abscessus_ATCC_199 KLGTMGLILNGSDELKKQVLPAIASGEAMASYALSEREAGSDAASMRTRA
Mflv_4943|M.gilvum_PYR-GCK SLSCHPLMSFGSDEQRQRWLPDMLGGSTIGAYSLSEPQAGSDAAALTCRA
Mvan_1476|M.vanbaalenii_PYR-1 SLSCHPLMSFGTDEQRQRWLPEMLGGSTIGAYSLSEPQAGSDAAALTCKA
MAV_2668|M.avium_104 VLSCHPLIAFGTDEQQQEWLPTMLGGHTIGAYSLSEPQAGSDAAALTCKA
MSMEG_0108|M.smegmatis_MC2_155 SLSSHPLLAFGTDEQKQRWLPGMLSGEQIGAYSLSEPQAGSDAAALRCAA
TH_4603|M.thermoresistible__bu SLSSHPLLVFGTEEQKKRWLPGMLSGEQIGAYSLSEPQAGSDAAALRCAA
*. *: *::: ::. ** : :.:*:*** :*****.:: *
MMAR_1262|M.marinum_M KADGDDWILNGTKCWITNGGKSSWYTVMAVTDPEKGANGISAFMVHKDDE
MUL_2626|M.ulcerans_Agy99 KADGDDWILNGTKCWITNGGKSSWYTVMAVTDPENGANGISAFVVHKDDE
Mb3302c|M.bovis_AF2122/97 KADGDHWILNGAKCWITNGGKSTWYTVMAVTDPDRGANGISAFMVHKDDE
Rv3274c|M.tuberculosis_H37Rv KADGDHWILNGAKCWITNGGKSTWYTVMAVTDPDRGANGISAFMVHKDDE
MLBr_00737|M.leprae_Br4923 KADGDDWILNGFKCWITNGGKSTWYTVMAVTDPDKGANGISAFIVHKDDE
MAB_3618c|M.abscessus_ATCC_199 KADGDDWIINGSKCWITNGGKSSWYTVMAVTDPEKKANGISAFMVHKDDE
Mflv_4943|M.gilvum_PYR-GCK TAVDGGYRITGSKAWITHGGIADFYNLFARTG--EGSQGISCFLVPRDTE
Mvan_1476|M.vanbaalenii_PYR-1 VAADGGYRINGAKAWITHGGIADFYNLFARTG--EGSQGISCFLVPRDTE
MAV_2668|M.avium_104 TATDGGYRVNGAKAWITHGGIADFYSLFARTG--EGGQGISCFLVDKDTE
MSMEG_0108|M.smegmatis_MC2_155 RRDGDGFVLNGSKAWITHGGRADFYTLFARTG--EGSKGVSCFLVPGDLP
TH_4603|M.thermoresistible__bu TPTDGGYVINGSKSWITHGGKADFYTLFARTG--EGSRGVSCFLVPADQP
.. : :.* *.***:** : :*.::* *. . ..*:*.*:* *
MMAR_1262|M.marinum_M GFVVGPKERKLGIKGSPTTELYFENCRVPGDRMIGEPGTGFKTALATLDH
MUL_2626|M.ulcerans_Agy99 GFVVGPKERKLGIKGSPTTELYFENCRVPGDRMIGEPGTGFKTALATLDH
Mb3302c|M.bovis_AF2122/97 GFTVGPKERKLGIKGSPTTELYFENCRIPGDRIIGEPGTGFKTALATLDH
Rv3274c|M.tuberculosis_H37Rv GFTVGPKERKLGIKGSPTTELYFENCRIPGDRIIGEPGTGFKTALATLDH
MLBr_00737|M.leprae_Br4923 GFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIGEPGTGFKTALATLDH
MAB_3618c|M.abscessus_ATCC_199 GFTVGPLEHKLGIKGSPTAELYFENCRIPGDRIIGEPGTGFKTALQTLDH
Mflv_4943|M.gilvum_PYR-GCK GLTFGKPEEKMGLHAVPTTAAHYDDANLDSDRRIGTEGQGLQIAFSALDS
Mvan_1476|M.vanbaalenii_PYR-1 GLTFGKPEEKMGLHAVPTTAAHYENAFVEADRRIGAEGQGLQIAFSALDS
MAV_2668|M.avium_104 GLTFGKPEEKMGLHAIPTTTAHYDNALVSAQRRIGAEGQGLQIAFSALDS
MSMEG_0108|M.smegmatis_MC2_155 GLSFGKPEEKMGLHAVPTTSAFYDNARIDADRLIGTEGQGLSIAFSALDS
TH_4603|M.thermoresistible__bu GLSFGKPEEKMGLHAVPTTSAFYDNARIDADRRIGEEGQGLQIAFSALDS
*: .* *.*:*::. **: .::.. : .:* ** * *:. *: :**
MMAR_1262|M.marinum_M TRPTIGAQAVGIAQGALDAAIAYTKDRKQFGKSISDFQAVQFMLADMAMK
MUL_2626|M.ulcerans_Agy99 TRPTIGAQAVGIAQGALDAAIAYTKDRKQFGKSISDFQAVQFMLADMAMK
Mb3302c|M.bovis_AF2122/97 TRPTIGAQAVGIAQGALDAAIAYTKDRKQFGESISTFQAVQFMLADMAMK
Rv3274c|M.tuberculosis_H37Rv TRPTIGAQAVGIAQGALDAAIAYTKDRKQFGESISTFQAVQFMLADMAMK
MLBr_00737|M.leprae_Br4923 TRPTIGAQAVGIAQGALDAAIVYTKDRKQFGESISTFQSIQFMLADMAMK
MAB_3618c|M.abscessus_ATCC_199 TRPTIGAQALGIAQGALDQAIAYTKDRKQFGKSISDFQGVQFMLADMAMK
Mflv_4943|M.gilvum_PYR-GCK GRLGIAAVAVGLAQAALDEAVAYSQERTTFGRKIIDHQGLAFLLADMAAA
Mvan_1476|M.vanbaalenii_PYR-1 GRLGIAAVAVGLAQAALDAAVDYSQERTTFGRKIIDHQGLAFLLADMAAA
MAV_2668|M.avium_104 GRLGIAAVAVGLAQAALDEAVSYAQQRTTFGRKIIDHQGLAFLLADMAAA
MSMEG_0108|M.smegmatis_MC2_155 GRLGIAAVAVGIAQAALDEAVRYAHERTTFGRKIIDHQGLGFLLADMAAA
TH_4603|M.thermoresistible__bu GRLGIAAVATGLAQAALDEAVAYANERTAFGRKIIDHQGLGFLLADMAAA
* *.* * *:**.*** *: *:::*. **..* .*.: *:*****
MMAR_1262|M.marinum_M VESARLMVYSAAARAERGESNLGFISAASKCLASDVAMEVTTDAVQLFGG
MUL_2626|M.ulcerans_Agy99 VESARLMVYSAAARAERGESNLGFISAASKCLASDVAMEVTTDAVQLFGG
Mb3302c|M.bovis_AF2122/97 VEAARLMVYSAAARAERGEPDLGFISAASKCFASDVAMEVTTDAVQLFGG
Rv3274c|M.tuberculosis_H37Rv VEAARLMVYSAAARAERGEPDLGFISAASKCFASDVAMEVTTDAVQLFGG
MLBr_00737|M.leprae_Br4923 VEAARLIVYAAAARAERGEPDLGFISAASKCFASDIAMEVTTDAVQLFGG
MAB_3618c|M.abscessus_ATCC_199 VEAARLMVYTAAARAERGEKNLGFISSASKCFASDVAMEVTTDAVQLFGG
Mflv_4943|M.gilvum_PYR-GCK VDSARATYLDAARRRDAGLP-YSRHASVAKLVATDAAMKVTTDAVQVLGG
Mvan_1476|M.vanbaalenii_PYR-1 VDAARATYLDAARRRDAGLP-YSRHASVAKLTATDAAMKVTTDAVQVFGG
MAV_2668|M.avium_104 VDSARATYLDAARRRDAGLP-YSRNASVAKLIATDAAMKVTTDAVQVFGG
MSMEG_0108|M.smegmatis_MC2_155 VVSARATYLDAARRRDAGLP-YSSQASVAKLVATDAAMKVTTDAVQVLGG
TH_4603|M.thermoresistible__bu VATARATYLDAARRRDQGRP-YSQQASIAKLTATDAAMKVTTDAVQVFGG
* :** ** * : * . :: :* *:* **:*******::**
MMAR_1262|M.marinum_M AGYTVDFPVERMMRDAKITQIYEGTNQIQRVVMSRALLR-
MUL_2626|M.ulcerans_Agy99 AGYTVDFPVERMMRDAKITQIYEGTNQIQRVVMSRALLR-
Mb3302c|M.bovis_AF2122/97 AGYTTDFPVERFMRDAKITQIYEGTNQIQRVVMSRALLR-
Rv3274c|M.tuberculosis_H37Rv AGYTTDFPVERFMRDAKITQIYEGTNQIQRVVMSRALLR-
MLBr_00737|M.leprae_Br4923 AGYTSDFPVERFMRDAKITQIYEGTNQIQRVVMSRALLR-
MAB_3618c|M.abscessus_ATCC_199 AGYTTDFPVERMMRDAKITQIYEGTNQIQRVVMSRALLTS
Mflv_4943|M.gilvum_PYR-GCK AGYTRDYRVERYMREAKITQIFEGTNQIQRLVISRHLTRG
Mvan_1476|M.vanbaalenii_PYR-1 AGYTRDYRVERYMREAKITQIFEGTNQIQRLVISRHLARD
MAV_2668|M.avium_104 YGYTRDYRVERYMREAKITQIFEGTNQIQRLVIGRSLVGS
MSMEG_0108|M.smegmatis_MC2_155 VGYTRDFRVERYMREAKITQIFEGTNQIQRLVISRGLGT-
TH_4603|M.thermoresistible__bu VGYTRDYRVERYMREAKIMQIFEGTNQIQRLVIARGLTR-
*** *: *** **:*** **:********:*:.* *