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VPVAPVERYLKYLTDIERSPNTIKAYAHDLKDWFTFLGGRGLDWQSVSLEDIGAFVVWLRLPTALRQGGI AVLPSVEHHCGESTVNRKLSALAAFYLHAVRDGIDVGELLTTWQIGGSRGGWKPFLHHISKHMPSPRRTV SLKAPKKLPRVLTPGEVQTLLDACDRLRDRFLLALLYDAGMRIGEALGLRHSDIAAAERQVTVCRRDNDN RARAKSLTARIVPVSAELIRLYADYLHAEYGDLDSDYVFVNLWGRPHGHPLTYGAVYDLVRRLRRRTAID FDPHWLRHTAATRMLRDGIGLEVVAKLLGHANVTVTAATYGHLNVEDARKAMEQAGWFIGKAQVKL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4155 | - | - | 100% (346) | transposase A |
| M. smegmatis MC2 155 | MSMEG_3744 | xerD | 1e-18 | 29.22% (332) | site-specific tyrosine recombinase XerD |
| M. smegmatis MC2 155 | MSMEG_2515 | xerC | 7e-13 | 30.18% (222) | site-specific tyrosine recombinase XerC |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2918c | xerC | 4e-19 | 29.59% (338) | site-specific tyrosine recombinase XerC |
| M. gilvum PYR-GCK | Mflv_4645 | - | 6e-28 | 30.70% (329) | phage integrase family protein |
| M. tuberculosis H37Rv | Rv2894c | xerC | 4e-19 | 29.59% (338) | site-specific tyrosine recombinase XerC |
| M. leprae Br4923 | MLBr_01365 | xerD | 3e-19 | 29.09% (330) | site-specific tyrosine recombinase XerD |
| M. abscessus ATCC 19977 | MAB_0442 | - | 2e-38 | 33.33% (378) | putative transposase/integrase |
| M. marinum M | MMAR_1433 | - | 2e-28 | 30.36% (336) | site-specific integrase |
| M. avium 104 | MAV_0505 | - | 5e-38 | 30.85% (376) | putative transposase |
| M. thermoresistible (build 8) | TH_3114 | - | 2e-40 | 33.87% (375) | PUTATIVE phage integrase family protein |
| M. ulcerans Agy99 | MUL_2065 | xerC | 8e-18 | 28.86% (343) | site-specific tyrosine recombinase XerC |
| M. vanbaalenii PYR-1 | Mvan_2147 | - | 4e-98 | 53.59% (334) | phage integrase family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2918c|M.bovis_AF2122/97 --------------------------------------------------
Rv2894c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_2065|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01365|M.leprae_Br4923 --------------------------------------------------
Mflv_4645|M.gilvum_PYR-GCK -------------------------------MTIQHQLRLQAGTDVAWVL
MMAR_1433|M.marinum_M ---------------------------------MTKELAAVVDDDGVWQL
MSMEG_4155|M.smegmatis_MC2_155 --------------------------------------MP----------
Mvan_2147|M.vanbaalenii_PYR-1 --------------------------------MRVQQVLPPDGGPESWTV
MAB_0442|M.abscessus_ATCC_1997 MILSTPARAVRSSSWIEPDPAGRHKQAGSGSAVARTQRITLTGRAHTYTV
TH_3114|M.thermoresistible__bu --------------------------------MARTQRIALTDRPDTYTV
MAV_0505|M.avium_104 -------------------------------MVARSQRVSFGEGPDTYTV
Mb2918c|M.bovis_AF2122/97 ------MQAILDEFDEYLALQCGRSVHTRRAYLGDLRSLFAFLADRGSSL
Rv2894c|M.tuberculosis_H37Rv ------MQAILDEFDEYLALQCGRSVHTRRAYLGDLRSLFAFLADRGSSL
MUL_2065|M.ulcerans_Agy99 --MPDNSEAILEEFDEYLALQCGRSAHTRRAYLGDLRSLLDYLAGRGADL
MLBr_01365|M.leprae_Br4923 -MTTAALQTQLQGYLDYLIIERSIAANTLSSYRRDLIRYSKHLSDRGIED
Mflv_4645|M.gilvum_PYR-GCK SGPGCGKYALVNEYLRYLADRN-YSPRTLRAYGYDLLAFCRWLGSVDVEL
MMAR_1433|M.marinum_M RGTAAEQFGLVNEFLGYLADRN-FSPRTCRAYAYDLLAFARWLRDEQLGV
MSMEG_4155|M.smegmatis_MC2_155 -------VAPVERYLKYLTDIE-RSPNTIKAYAHDLKDWFTFLGGRGLDW
Mvan_2147|M.vanbaalenii_PYR-1 LDERFAVVEPADVFLAHLTAIE-RSPGTVRAYAFDLRDYFEFLAAHGIDW
MAB_0442|M.abscessus_ATCC_1997 LGQDHLPIAPVTEYLQFLRDDQ-ASPNTLRAYAAGLAAWWNLLEETNTGW
TH_3114|M.thermoresistible__bu LGADHLPVDPAEEYLQFLRDDA-ASPNTVKAYAAGLAAWWTLLEYTGTDW
MAV_0505|M.avium_104 VGDDGLPIGPAAEYLRFLRDGG-ASPHTVRAYAAGIADWFTVLSHTGHVW
: .* : * :* .: *
Mb2918c|M.bovis_AF2122/97 DALT--------LSVLRSWLAATA-----------GAGAARTTLARRTSA
Rv2894c|M.tuberculosis_H37Rv DALT--------LSVLRSWLAATA-----------GAGAARTTLARRTSA
MUL_2065|M.ulcerans_Agy99 RALS--------LPVLRSWLATAA-----------GAGAARTTLARRTSA
MLBr_01365|M.leprae_Br4923 LAKVGEHDVSEFLVALRRGDPDSG-----------VAALSAVSAARALIA
Mflv_4645|M.gilvum_PYR-GCK SSVTTETVLDFMRHCRQTPIAGRP-TNVVSMTGTRLDRYSSTTINHRLAA
MMAR_1433|M.marinum_M AEVNVDVLLRFLTACREATLPGRPGGNVYSIRDGRNQGYAPATINRRLAA
MSMEG_4155|M.smegmatis_MC2_155 QSVSLEDIGAFVVWLRLPTALRQG---GIAVLPSVEHHCGESTVNRKLSA
Mvan_2147|M.vanbaalenii_PYR-1 RAVRLEHLGRFVGWLRLPPTQRTA---SVTSLSTMEAQCSASTINRKLAA
MAB_0442|M.abscessus_ATCC_1997 TDVTTALFGEFLTYLRTGDLPGTS---RIGPPAVWLSAASVQQRAAAVLS
TH_3114|M.thermoresistible__bu REVSTAMFGQFLAYLRSGDLPGTA---RIGAPPTWLGPASTQLRAAAVLA
MAV_0505|M.avium_104 DDFPTTLFGQYLQFLRTGDLPGSA---RIGPPQQRLAASSLQPRAAAVLS
. :
Mb2918c|M.bovis_AF2122/97 VKAFTAWAVRRG--------------LLAGDPAARLQVPKARRTLPAVLR
Rv2894c|M.tuberculosis_H37Rv VKAFTAWAVRRG--------------LLAGDPAARLQVPKARRTLPAVLR
MUL_2065|M.ulcerans_Agy99 VKAFTAWAVRRG--------------LLATDPAARLQVPKAHRTLPAVLR
MLBr_01365|M.leprae_Br4923 VRGLHRFAVAEG--------------LVDLDVARAVRPPTPGRRLPKSLT
Mflv_4645|M.gilvum_PYR-GCK LTGLFTFRELRDPGLRTPIPSGREARRVSAEERNGLLGHLVRPKRRSALR
MMAR_1433|M.marinum_M ISSLFAFREMRDPDARSLVGSSRAARLRSRGERSGLLAHTAKPKSRSQLR
MSMEG_4155|M.smegmatis_MC2_155 LAAFYLHAVRDGIDVGELLTTWQIGGSRGGWKPFLHHISKHMPSPRRTVS
Mvan_2147|M.vanbaalenii_PYR-1 VGSFYKFYHRHGVGCGELLSTMKAGGARGSWRPFLAHLGSAGDQHRRTIK
MAB_0442|M.abscessus_ATCC_1997 FYRYHAHAHNLDAPYQRLYGTLGKPGRAR-YIPLLAGVGRPVRKPRPIYR
TH_3114|M.thermoresistible__bu CYRYHADAHGLPVPYRRLFTSRGKRGRSR-YIPMLAGVGPPRTKDRPVYT
MAV_0505|M.avium_104 MYRYHADAHHVDTPYRRLFTSRGSWRRYRRYVGFLDGVGPQRRGDHPIYR
Mb2918c|M.bovis_AF2122/97 QDQ----ALRAMAAAESGAEQGDPLALR-------------DRLIVELLY
Rv2894c|M.tuberculosis_H37Rv QDQ----ALRAMAAAESGAEQGDPLALR-------------DRLIVELLY
MUL_2065|M.ulcerans_Agy99 QDQ----ALAAMTAAKSSAQQGDPLALR-------------DRLIVELLY
MLBr_01365|M.leprae_Br4923 VDE----VLALLESVGGESRADGPLVLR-------------NRALLELLY
Mflv_4645|M.gilvum_PYR-GCK LREP-RRLPRALNRRETAELLSSLRTWR-------------DRALAGLML
MMAR_1433|M.marinum_M VREP-RWLPRGLSREESAALLGSFRSWR-------------DRAIGGLML
MSMEG_4155|M.smegmatis_MC2_155 LKAPKKLPR-VLTPGEVQTLLDACDRLR-------------DRFLLALLY
Mvan_2147|M.vanbaalenii_PYR-1 LKTRRRLPR-TLPEESVQLIVNACDRLR-------------DRFLIELLA
MAB_0442|M.abscessus_ATCC_1997 VRGGNTSRTPVLLPEQVRTILDLCAVQDRSGQWSGSPAALRDRLLFALLA
TH_3114|M.thermoresistible__bu VRRGNLAATPVLLPSQVAAILDGCATQN-GHVWSGPASGLRDRLLFATLA
MAV_0505|M.avium_104 MRTQNRCTTPVLTPPQVNTILDACSVQH-DGTWSGGPAAVRNRLLFAVLA
: . :* : :
Mb2918c|M.bovis_AF2122/97 ATGIRVSELCGLDVDDIDTGHR-------------LVRVLGKGNKQRTVP
Rv2894c|M.tuberculosis_H37Rv ATGIRVSELCGLDVDDIDTGHR-------------LVRVLGKGNKQRTVP
MUL_2065|M.ulcerans_Agy99 ATGIRVSELRGLDIDDVDTGHR-------------LVRVLGKGNKQRTAP
MLBr_01365|M.leprae_Br4923 STGSRISEAVGLDVDDVDTQAR-------------TVLLQGKGGKQRLVP
Mflv_4645|M.gilvum_PYR-GCK LSGLRSGELLTLDVTDVDIGAR-------------WVKVMGKGAKERRVP
MMAR_1433|M.marinum_M LSGLRSAEVLGLRVSDIDIARR-------------WVRVLGKGGKERSVP
MSMEG_4155|M.smegmatis_MC2_155 DAGMRIGEALGLRHSDIAAAE----RQVTVCRRDNDNRARAKSLTARIVP
Mvan_2147|M.vanbaalenii_PYR-1 GTGMRIGEALGLRHEDIDAAG----TLIRIRARRNSNGARVKGG-QREIP
MAB_0442|M.abscessus_ATCC_1997 ETGMRMGEALTLRHHDVHIGAGGTPWVEVVPRQDHPAGVRVKGGH-RRIY
TH_3114|M.thermoresistible__bu ETGMRLGEALSLRHHDFHLGTGATPYIEVGTRQDHPRGARGKTLHGRRIY
MAV_0505|M.avium_104 ETGMRLGEALSLRHHDFHIGAGATPFIEIVDRQDHPHGVRVKTGS-RRVY
:* * .* * *. * *
Mb2918c|M.bovis_AF2122/97 FGQPAADALHAWLVDGRR--------ALVTAESG----HALLLGARGRRL
Rv2894c|M.tuberculosis_H37Rv FGQPAADALHAWLVDGRR--------ALVTAESG----HALLLGARGRRL
MUL_2065|M.ulcerans_Agy99 FGQPAAEALQAWLADGRP--------ALATAESG----PALLLGARGRRL
MLBr_01365|M.leprae_Br4923 VGRPAVQALDAYLVRGRS--------DLARRGPGMLATPAIFLNARGGRL
Mflv_4645|M.gilvum_PYR-GCK LDVEVAGLIQTYLLVERP--------ESDSNRLF----LVAKGPHRGQPL
MMAR_1433|M.marinum_M IDTDVAGAIQTYLLAERP--------ETDADELF----VVAKGAHRGRPL
MSMEG_4155|M.smegmatis_MC2_155 VSAELIRLYADYLHAEYG--------DLDSDYVF----VNLWGRPHGHPL
Mvan_2147|M.vanbaalenii_PYR-1 VAASLIRLYTDYLVDEYG--------ELDCDYVF----VNLWGGSVGTPL
MAB_0442|M.abscessus_ATCC_1997 VGDDLEALYSAYVWHLVDTGAHEHVPDLDTHFVF----VNLAGGQLYAPT
TH_3114|M.thermoresistible__bu IGDDLEALYSSYVWHLVDHGADLAMPNLDTHFVF----VNLVAGERFAPM
MAV_0505|M.avium_104 VGDDLEALYSEYVWQLVAMAADVEVPDLASHFVF----VNLAHGPRFAAM
. ::
Mb2918c|M.bovis_AF2122/97 DVRQARTAVHQTVA--AVDGAPDMGPHGLRHSAATHLLEGGADLRVVQEL
Rv2894c|M.tuberculosis_H37Rv DVRQARTAVHQTVA--AVDGAPDMGPHGLRHSAATHLLEGGADLRVVQEL
MUL_2065|M.ulcerans_Agy99 DVRQARTVVHQTIA--AVDGAPDMGPHGLRHSAATHLLEGGADLRVVQEL
MLBr_01365|M.leprae_Br4923 SRQSAWQVLQDAAE--HAGITSGVSPHMLRHSFATHLLEGGADIRVVQEL
Mflv_4645|M.gilvum_PYR-GCK TAAGLRTIFRYHRI--KSGVLAGH-PHALRHTFGTAMAEAGVDLAVMQAL
MMAR_1433|M.marinum_M TAAGLRTVFRYHRE--RSGVAAGH-PHALRHSFGTALAEAGVDLSVIQAL
MSMEG_4155|M.smegmatis_MC2_155 TYGAVYDLVRRLRR----RTAIDFDPHWLRHTAATRMLRDGIGLEVVAKL
Mvan_2147|M.vanbaalenii_PYR-1 RYWNVTDLVSRLRA----RSGVEFTVHMLRHTYATDLLRRGVPAEVVQKL
MAB_0442|M.abscessus_ATCC_1997 RPETVYAKVRSISHNAKGAVPKDWSPHWMRHTHATALLLSGVPPHVVMRR
TH_3114|M.thermoresistible__bu RAETVYAKVDSLTRRSNGVLPEDWTPHWLRHTHATALLLSGAPPHVVMRR
MAV_0505|M.avium_104 RVETVYDKVRGIKR-AQPSLPAGWTPHWLRHTHATALLLAGVPEHVVMRR
. * :**: .* : * *:
Mb2918c|M.bovis_AF2122/97 LGHSSLATTQ-LYTHVAVARLRAVHERAHPRA------------
Rv2894c|M.tuberculosis_H37Rv LGHSSLATTQ-LYTHVAVARLRAVHERAHPRA------------
MUL_2065|M.ulcerans_Agy99 LGHSSLATTQ-LYTHVAVSRLRAVHDQAHPRA------------
MLBr_01365|M.leprae_Br4923 MGHASVTTTQ-IYTLVTVQALREVWAGAHPRAK-----------
Mflv_4645|M.gilvum_PYR-GCK LGHAHIDTTA-RYIHLAPTHVKAEYDAARTRLRSHT--------
MMAR_1433|M.marinum_M MGHDHVDSAA-AYIHLAPTFLREEFDAARARLRARS--------
MSMEG_4155|M.smegmatis_MC2_155 LGHANVTVTAATYGHLNVEDARKAMEQAGWFIGKAQVKL-----
Mvan_2147|M.vanbaalenii_PYR-1 LGHASVTTTASTYAHLEVEDLRRVLRDKGCLDRAVEGQ------
MAB_0442|M.abscessus_ATCC_1997 LGHQDIQTTLSTYGWVTEDAEMRSVAEWRNFVAGWKGLHDDPH-
TH_3114|M.thermoresistible__bu LGHADIQTTLSTYGWVTEDAEMRTVAQWRNYVAGWKGLHHDDTP
MAV_0505|M.avium_104 LGHADVQTTLSTYGWVTQDAEMRSLASWKNYVAGWKGLHDGPP-
:** : : * :