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TIQHQLRLQAGTDVAWVLSGPGCGKYALVNEYLRYLADRNYSPRTLRAYGYDLLAFCRWLGSVDVELSSV TTETVLDFMRHCRQTPIAGRPTNVVSMTGTRLDRYSSTTINHRLAALTGLFTFRELRDPGLRTPIPSGRE ARRVSAEERNGLLGHLVRPKRRSALRLREPRRLPRALNRRETAELLSSLRTWRDRALAGLMLLSGLRSGE LLTLDVTDVDIGARWVKVMGKGAKERRVPLDVEVAGLIQTYLLVERPESDSNRLFLVAKGPHRGQPLTAA GLRTIFRYHRIKSGVLAGHPHALRHTFGTAMAEAGVDLAVMQALLGHAHIDTTARYIHLAPTHVKAEYDA ARTRLRSHT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4645 | - | - | 100% (360) | phage integrase family protein |
| M. gilvum PYR-GCK | Mflv_3500 | xerD | 2e-22 | 29.13% (333) | site-specific tyrosine recombinase XerD |
| M. gilvum PYR-GCK | Mflv_4135 | xerC | 2e-20 | 32.59% (224) | site-specific tyrosine recombinase XerC |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2918c | xerC | 7e-23 | 27.38% (336) | site-specific tyrosine recombinase XerC |
| M. tuberculosis H37Rv | Rv2894c | xerC | 7e-23 | 27.38% (336) | site-specific tyrosine recombinase XerC |
| M. leprae Br4923 | MLBr_01600 | xerC | 2e-22 | 32.54% (209) | site-specific tyrosine recombinase XerC |
| M. abscessus ATCC 19977 | MAB_2366 | xerD | 3e-21 | 27.81% (338) | site-specific tyrosine recombinase XerD |
| M. marinum M | MMAR_1433 | - | 1e-121 | 60.63% (348) | site-specific integrase |
| M. avium 104 | MAV_3746 | xerC | 9e-22 | 32.85% (207) | site-specific tyrosine recombinase XerC |
| M. smegmatis MC2 155 | MSMEG_4155 | - | 8e-28 | 30.70% (329) | transposase A |
| M. thermoresistible (build 8) | TH_2462 | - | 2e-62 | 41.02% (334) | PUTATIVE phage integrase family protein |
| M. ulcerans Agy99 | MUL_2065 | xerC | 6e-22 | 32.91% (237) | site-specific tyrosine recombinase XerC |
| M. vanbaalenii PYR-1 | Mvan_1113 | - | 1e-120 | 60.87% (345) | phage integrase family protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1433|M.marinum_M ------MTKELAAVVDDDGVWQLRGTAAEQFGLVNEFLGYLADRN-FSPR
Mvan_1113|M.vanbaalenii_PYR-1 MRYAHLMTKELSAAVDG-GVWQLRGPAAERFGLVNDFLGHLADRN-FSVH
Mflv_4645|M.gilvum_PYR-GCK ----MTIQHQLRLQAGTDVAWVLSGPGCGKYALVNEYLRYLADRN-YSPR
TH_2462|M.thermoresistible__bu ------MTVRVRTHGDG---YAIDG-QWEGSAAANAFLTHLAGRG-FSAA
MAV_3746|M.avium_104 -------------------------MPD-SEPILEEFDEYLALQCGRSAH
MUL_2065|M.ulcerans_Agy99 -------------------------MPDNSEAILEEFDEYLALQCGRSAH
MLBr_01600|M.leprae_Br4923 ------------------------------MAILDEFDEHLALRCGRSEH
Mb2918c|M.bovis_AF2122/97 -----------------------------MQAILDEFDEYLALQCGRSVH
Rv2894c|M.tuberculosis_H37Rv -----------------------------MQAILDEFDEYLALQCGRSVH
MAB_2366|M.abscessus_ATCC_1997 ----------------------MTAAVGLLDGEIQSYLDHLDVERGVAAN
MSMEG_4155|M.smegmatis_MC2_155 ----------------------------MPVAPVERYLKYLTDIE-RSPN
: : :* :
MMAR_1433|M.marinum_M TCRAYAYDLLAFARWLRDEQLG-VAEVNVDVLLRFLTACREATLPGRPGG
Mvan_1113|M.vanbaalenii_PYR-1 TCRAYAYDLLAFARWLIDEQVE-LAEVNVDVLLRFLTACREATLPGRPGG
Mflv_4645|M.gilvum_PYR-GCK TLRAYGYDLLAFCRWLGSVDVE-LSSVTTETVLDFMRHCRQTPIAGRP-T
TH_2462|M.thermoresistible__bu TVRAYAFDVLNLARFLLDRDLT-VAAVTPVTVFEWID-WQDVRREPRP--
MAV_3746|M.avium_104 TRRAYLGDLRSLLAFAGERGTG-LDGLSLPLLRSWLSAAAAGGVAR----
MUL_2065|M.ulcerans_Agy99 TRRAYLGDLRSLLDYLAGRGAD-LRALSLPVLRSWLATAAGAGAAR----
MLBr_01600|M.leprae_Br4923 TRRAYLGDLRSLLTHLEGRGSR-LDQLSLPVLRSWLATAAGAGAAR----
Mb2918c|M.bovis_AF2122/97 TRRAYLGDLRSLFAFLADRGSS-LDALTLSVLRSWLAATAGAGAAR----
Rv2894c|M.tuberculosis_H37Rv TRRAYLGDLRSLFAFLADRGSS-LDALTLSVLRSWLAATAGAGAAR----
MAB_2366|M.abscessus_ATCC_1997 TLSSYRRDLRRYQQHLADRKIDRLAEVCETDVSDFVVTLRRGDPANGV--
MSMEG_4155|M.smegmatis_MC2_155 TIKAYAHDLKDWFTFLGGRGLD-WQSVSLEDIGAFVVWLRLPTALRQG--
* :* *: : : ::
MMAR_1433|M.marinum_M NVYSIRDGRNQGYAPATINRRLAAISSLFAFREMRDPDARSLVGSSRAAR
Mvan_1113|M.vanbaalenii_PYR-1 NVYSIRDGRNQGYAPATINRRLAAISSLFAFQEMREPDARNPVSGGRSAR
Mflv_4645|M.gilvum_PYR-GCK NVVSMTGTRLDRYSSTTINHRLAALTGLFTFRELRDPGLRTPIPSGREAR
TH_2462|M.thermoresistible__bu ---GMATRGDRGAAASTINRRVAAVRALFEYLVMTRMRADNPVPSPRRGQ
MAV_3746|M.avium_104 ---------------TTLARRTSAVKAFTAWAVRRGLLTADPAAR-----
MUL_2065|M.ulcerans_Agy99 ---------------TTLARRTSAVKAFTAWAVRRGLLATDPAAR-----
MLBr_01600|M.leprae_Br4923 ---------------TTLARRISAVKAFTAWAKWRGQLAADPAAR-----
Mb2918c|M.bovis_AF2122/97 ---------------TTLARRTSAVKAFTAWAVRRGLLAGDPAAR-----
Rv2894c|M.tuberculosis_H37Rv ---------------TTLARRTSAVKAFTAWAVRRGLLAGDPAAR-----
MAB_2366|M.abscessus_ATCC_1997 ----------PELSASSAARALIAVRGLHRFAAIEGLAPTDVARA-----
MSMEG_4155|M.smegmatis_MC2_155 -GIAVLPSVEHHCGESTVNRKLSALAAFYLHAVRDGIDVGELLTTWQIGG
:: : *: .:
MMAR_1433|M.marinum_M LRSRGERSGLLAHTAKPKSRSQLR-VREPRWLPRGLSREESAALLGSFRS
Mvan_1113|M.vanbaalenii_PYR-1 LRSRGERSGLLTHIAKPKSRSQLR-VREQRRLPRGLTRQESAALLGSFRS
Mflv_4645|M.gilvum_PYR-GCK RVSAEERNGLLGHLVRPKRRSALR-LREPRRLPRALNRRETAELLSSLRT
TH_2462|M.thermoresistible__bu GLRPQAR-GLLGHLGPGRPRAGGRLVRQPRLLPESLDADAVEQFVASLRT
MAV_3746|M.avium_104 -------------LQVPKTHRTLPAVLRQDQALGAMAAAKNGAAQGDPIA
MUL_2065|M.ulcerans_Agy99 -------------LQVPKAHRTLPAVLRQDQALAAMTAAKSSAQQGDPLA
MLBr_01600|M.leprae_Br4923 -------------LQVPRAYRTLPAVLRQDQALQIMAAAKSGAEQGDPLA
Mb2918c|M.bovis_AF2122/97 -------------LQVPKARRTLPAVLRQDQALRAMAAAESGAEQGDPLA
Rv2894c|M.tuberculosis_H37Rv -------------LQVPKARRTLPAVLRQDQALRAMAAAESGAEQGDPLA
MAB_2366|M.abscessus_ATCC_1997 -------------VKPPTPNRRLPKSLTVEQVEALLNAAGGGGSDG-PLD
MSMEG_4155|M.smegmatis_MC2_155 SRGGWKPFLHHISKHMPSPRRTVS-LKAPKKLPRVLTPGEVQTLLDACDR
:
MMAR_1433|M.marinum_M WRDRAIGGLMLLSGLRSAEVLGLRVSDIDIARRWVRVLGKGGKERS----
Mvan_1113|M.vanbaalenii_PYR-1 WRDRSIGGLMLMSGLRSTEVLSVRVADVDIARRWVRVLGKGSKERS----
Mflv_4645|M.gilvum_PYR-GCK WRDRALAGLMLLSGLRSGELLTLDVTDVDIGARWVKVMGKGAKERR----
TH_2462|M.thermoresistible__bu HRDRAMVWAMLFGGLRSAEVRSLRLADVDFGRRRLRVLGKGSKERV----
MAV_3746|M.avium_104 LRDRLIVEMLYATGIRVSELCGLDIDDVDTGRRLVRVLGKGNKQRS----
MUL_2065|M.ulcerans_Agy99 LRDRLIVELLYATGIRVSELRGLDIDDVDTGHRLVRVLGKGNKQRT----
MLBr_01600|M.leprae_Br4923 LRDRLIVEMLYATGIRVSELCGLDIDDVDTRHRLVRVLGKGNKQRT----
Mb2918c|M.bovis_AF2122/97 LRDRLIVELLYATGIRVSELCGLDVDDIDTGHRLVRVLGKGNKQRT----
Rv2894c|M.tuberculosis_H37Rv LRDRLIVELLYATGIRVSELCGLDVDDIDTGHRLVRVLGKGNKQRT----
MAB_2366|M.abscessus_ATCC_1997 LRNRALLELLYSTGARISEAVGLDVDDVDVQARSVLLWGKGGKQRL----
MSMEG_4155|M.smegmatis_MC2_155 LRDRFLLALLYDAGMRIGEALGLRHSDIAAAERQVTVCRRDNDNRARAKS
*:* : : * * * : *: * : : :. .:*
MMAR_1433|M.marinum_M --VPIDTDVAGAIQTYLLAERPE-TDADEL--FVVAKGAHRGRPLTAAGL
Mvan_1113|M.vanbaalenii_PYR-1 --VPIDTDVAGAIQTYLLVERPE-TDAEAL--FVVAKGVHRGQPLTAAGL
Mflv_4645|M.gilvum_PYR-GCK --VPLDVEVAGLIQTYLLVERPE-SDSNRL--FLVAKGPHRGQPLTAAGL
TH_2462|M.thermoresistible__bu --VPVDAVFFTELSAYLRLERPPGLATQEC--FVVLRGPTHGSPVTEAGL
MAV_3746|M.avium_104 --VPFGAPAGEALHAWLADGRPALANAESG--PALLLGARGRRLDVRQAR
MUL_2065|M.ulcerans_Agy99 --APFGQPAAEALQAWLADGRPALATAESG--PALLLGARGRRLDVRQAR
MLBr_01600|M.leprae_Br4923 --APFGVPAADALRGWLDDGRPALVTVESG--PALLLGSRGRRLDVRQAR
Mb2918c|M.bovis_AF2122/97 --VPFGQPAADALHAWLVDGRRALVTAESG--HALLLGARGRRLDVRQAR
Rv2894c|M.tuberculosis_H37Rv --VPFGQPAADALHAWLVDGRRALVTAESG--HALLLGARGRRLDVRQAR
MAB_2366|M.abscessus_ATCC_1997 --VPVGRPAVEALQAYLVRGRPDLARRGRGGVPALFLNSRGGRLSRQSAW
MSMEG_4155|M.smegmatis_MC2_155 LTARIVPVSAELIRLYADYLHAEYGDLDSDYVFVNLWGRPHGHPLTYGAV
. . : : : . .
MMAR_1433|M.marinum_M RTVFRYHRERSGVAAGHPHALRHSFGTALAEAGVDLSVIQALMGHDHVDS
Mvan_1113|M.vanbaalenii_PYR-1 RTVFRYHRERSGVSAGHPHALRHSFGTALAEAGVDLSVIQALMGHDHADS
Mflv_4645|M.gilvum_PYR-GCK RTIFRYHRIKSGVLAGHPHALRHTFGTAMAEAGVDLAVMQALLGHAHIDT
TH_2462|M.thermoresistible__bu RSLFRRHRVLSGATRVRPHRLRHTYGTELASAGIDLMALRELMGHVSPET
MAV_3746|M.avium_104 TVVHQTIAAVSGAPDMGPHGLRHSAATHLLEGGADLRVVQELLGHSSLAT
MUL_2065|M.ulcerans_Agy99 TVVHQTIAAVDGAPDMGPHGLRHSAATHLLEGGADLRVVQELLGHSSLAT
MLBr_01600|M.leprae_Br4923 TVVHQTVAVVAGAPDMGPHGLRHSAATHLLEGGADLRVVQELLGHSSLAT
Mb2918c|M.bovis_AF2122/97 TAVHQTVAAVDGAPDMGPHGLRHSAATHLLEGGADLRVVQELLGHSSLAT
Rv2894c|M.tuberculosis_H37Rv TAVHQTVAAVDGAPDMGPHGLRHSAATHLLEGGADLRVVQELLGHSSLAT
MAB_2366|M.abscessus_ATCC_1997 QVLADAAERAKISAAVSPHTLRHSFATHLLEGGADVRVVQELLGHASVTT
MSMEG_4155|M.smegmatis_MC2_155 YDLVRRLRRRT-AIDFDPHWLRHTAATRMLRDGIGLEVVAKLLGHANVTV
: ** ***: .* : * .: .: *:**
MMAR_1433|M.marinum_M AAA-YIHLAPTFLREEFDAARARLRARS---
Mvan_1113|M.vanbaalenii_PYR-1 AAA-YIHLAPTFLREEFDAARARLRSRS---
Mflv_4645|M.gilvum_PYR-GCK TAR-YIHLAPTHVKAEYDAARTRLRSHT---
TH_2462|M.thermoresistible__bu TAG-YVHLSVAQLAAEYGAARASLAGTRR--
MAV_3746|M.avium_104 TQL-YTHVAVSRLRAVHDQAHPRA-------
MUL_2065|M.ulcerans_Agy99 TQL-YTHVAVSRLRAVHDQAHPRA-------
MLBr_01600|M.leprae_Br4923 TQL-YTHVAVSRLRVVHDQAHPRA-------
Mb2918c|M.bovis_AF2122/97 TQL-YTHVAVARLRAVHERAHPRA-------
Rv2894c|M.tuberculosis_H37Rv TQL-YTHVAVARLRAVHERAHPRA-------
MAB_2366|M.abscessus_ATCC_1997 TQI-YTLVTVSALREVWAGAHPRAR------
MSMEG_4155|M.smegmatis_MC2_155 TAATYGHLNVEDARKAMEQAGWFIGKAQVKL
: * : *