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TRVATNRIGAGVEDGRPFRLGFLLHLDRDIPPAQAYREAVELFVAAEQLGYDSGWVIHRHFRQGNEHVSA PLVLLAAIAQHTSRIRLGTGVLVLALEDPLKVAEDAATLDEISGGRLELGVGSGPFPSAWEAFGRDLNDR HRIFNDVVDRLHDVLDGHVLNSVGETLHPPGAGVRRRLWQAITSDAVHSGPAAVRAATAGDGLQLSRATA WQGGSVEDAQIRQSEWIAAYRDAWADPASPPRVQVSRAVYPHGDRAEALRLVTPGVRRWQSWSTHGDPRQ TETVDEYLTADRALIGPGAELADELASDPALRHASDLLLSFVPGVPEHGEHLRLLEDTARELVPRLGWYP STGVS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4092 | - | - | 100% (356) | alkanal monooxygenase |
| M. smegmatis MC2 155 | MSMEG_3583 | - | 9e-27 | 29.91% (331) | monooxygenase |
| M. smegmatis MC2 155 | MSMEG_1475 | - | 1e-13 | 41.76% (91) | hypothetical protein MSMEG_1475 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1971 | - | 1e-10 | 34.86% (109) | monooxygenase |
| M. gilvum PYR-GCK | Mflv_4429 | - | 4e-15 | 26.45% (310) | luciferase family protein |
| M. tuberculosis H37Rv | Rv3618 | - | 3e-15 | 26.21% (309) | monooxygenase |
| M. leprae Br4923 | MLBr_00269 | - | 2e-08 | 27.92% (197) | putative F420-dependent glucose-6-phosphate dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4628c | - | 2e-20 | 33.33% (216) | luciferase-like monooxygenase |
| M. marinum M | MMAR_1055 | - | 2e-15 | 45.05% (91) | flavin-dependent oxidoreductase |
| M. avium 104 | MAV_2779 | - | 7e-14 | 31.30% (131) | limonene 1,2-monooxygenase |
| M. thermoresistible (build 8) | TH_3375 | - | 3e-19 | 39.52% (124) | PUTATIVE putative conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_4194 | - | 2e-15 | 36.67% (120) | monooxygenase |
| M. vanbaalenii PYR-1 | Mvan_4242 | - | 8e-14 | 32.20% (118) | luciferase family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3618|M.tuberculosis_H37Rv ------------MKAPLRFGVFITPFHPTGQSPTVALQYDMERVVALDRL
MUL_4194|M.ulcerans_Agy99 ----------MVTDAPLKFGVFITPFHPTGQSPTVALEYDMERVVALDRL
Mflv_4429|M.gilvum_PYR-GCK ----------------MRFGNFMAPFHPVGQNPTLALERDLDLIVAMDRL
MAV_2779|M.avium_104 -------------MGKLRFGYFIAPFHRAGTNPTLALQRDLEFIEHLDAL
Mb1971|M.bovis_AF2122/97 ----------------MEIGIFLMPAHPPERTLYDATRWDLDVIELADQL
MMAR_1055|M.marinum_M ----------------MRFSIAIPQLDTDG----FDAAGLRAYLARAEEL
Mvan_4242|M.vanbaalenii_PYR-1 -------------MKISLFYEFPLPRPWSEDDEHQLFQHGLDEVELADKA
MAB_4628c|M.abscessus_ATCC_199 ----------MRFQLLDIVFHLPNPATRALAPAAERLNRVIETAVLAENL
TH_3375|M.thermoresistible__bu ---------------VGLGALTAQTRSGTAAESTEALTMLLDTCVLAEDE
MSMEG_4092|M.smegmatis_MC2_155 MTRVATNRIGAGVEDGRPFRLGFLLHLDRDIPPAQAYREAVELFVAAEQL
MLBr_00269|M.leprae_Br4923 --------------------MAELRLGYKASAEQFAPRELVELGVAAEAH
:
Rv3618|M.tuberculosis_H37Rv GYDEAWFGEH---HSGGYELIACPEVFIAAAAERTTHIRLGTGVVSLP--
MUL_4194|M.ulcerans_Agy99 GYDEAWFGEH---HSGGYELIACPEVFIAAAAERTKHIRLGTGVVSLP--
Mflv_4429|M.gilvum_PYR-GCK GFHEAWVGEH---HSAGFEIIASPEVFLGVAAERTKHIRLGTGVSSLP--
MAV_2779|M.avium_104 GFDEVWLGEH---HSAGSEIISSPEIFIAAAAERAKRIRFGTGVISLS--
Mb1971|M.bovis_AF2122/97 GYVEAWVGEH---FTVPWEPICAPDLLLAQALLRTQQIKLAPGAHLLP--
MMAR_1055|M.marinum_M GFEGGWVLEQ---IIG-SSPLLAPLELLAYCAACTNRLRLGVAVLVTS--
Mvan_4242|M.vanbaalenii_PYR-1 GFSTVWLTEHH--FLEEYCHSTAPELFLAAASQRTKNIRLGFGVMHLPPP
MAB_4628c|M.abscessus_ATCC_199 GFDSFAVGER----HAGDVLSSAPTVLLGAVAAATDRILLSTGVTVLS--
TH_3375|M.thermoresistible__bu GLDSAWVAEH---HFAADGFLSSPMTVLAALSQRTSRIRLSTNVMIGP--
MSMEG_4092|M.smegmatis_MC2_155 GYDSGWVIHRH--FRQGNEHVSAPLVLLAAIAQHTSRIRLGTGVLVLA--
MLBr_00269|M.leprae_Br4923 GMDSATVSDHFQPWRHQGGHASFSLSWMTAVGERTNRILLGTSVLTPT-F
* . .: . : : .: :. . .
Rv3618|M.tuberculosis_H37Rv YHHPLMVADRWVLLDHLTRGRVMFGTGPGALPSDAYM--MGIDPV--EQR
MUL_4194|M.ulcerans_Agy99 YHHPLMVADRWVLLDHLTRGRVVFGTGPGALPSDAYM--MGIDPI--DQR
Mflv_4429|M.gilvum_PYR-GCK YHHPLMLADRMVLLDHLTRGRVMLGCGPGQLTSDAHM--LGIPAD--EQR
MAV_2779|M.avium_104 YHNPLWVADRLMLLDHLTHGRIIGGVGPGSLPTDSSM--IGLTPT--DTR
Mb1971|M.bovis_AF2122/97 YHHPVELAHRVAYFDHLAQGRFMLGVGASGIPGDWAL--YDVDGKNGEHR
MMAR_1055|M.marinum_M LHDPLQLASSVTAVDRLSNGRLDLGVAAGGGSRKFAA--FGVDRA--THV
Mvan_4242|M.vanbaalenii_PYR-1 INHPARIAERVATLDHLSNGRVEYGTGEGSSVAELGG--FNIDPA--DKR
MAB_4628c|M.abscessus_ATCC_199 LLDPVRAAEDFATIDQLSRGRLEIVIGKGNEDRQYPL--MGLDIA--KQY
TH_3375|M.thermoresistible__bu LYDPIRLAEDAAVVDQLSRGRLMLGLGLGYRDVEFAG--LGRRRQ--ERG
MSMEG_4092|M.smegmatis_MC2_155 LEDPLKVAEDAATLDEISGGRLELGVGSGPFPSAWEA--FGRDLN--DRH
MLBr_00269|M.leprae_Br4923 RYNPAVIGQAFATMGCLYPNRVFLGVGTGEALNEVATGYQGAWPEFKERF
.* . .. : .*. . . .
Rv3618|M.tuberculosis_H37Rv RMMQESLEAILALFRAAPDERIDRHSDWFTLR--------EAQLHIRPYT
MUL_4194|M.ulcerans_Agy99 RMMQESLEAILALLRAAPGERIDRHSDWFTLR--------DAQLHIRPYT
Mflv_4429|M.gilvum_PYR-GCK PRMEQCLDAIVRLLR---GETVTMHTDGFTLQ--------DARLQLKPYS
MAV_2779|M.avium_104 ELLETNLDIVVRLLA---GETVSAKTATHQLF--------DAKLQLGPYS
Mb1971|M.bovis_AF2122/97 EMTREALEIMLRIWTE--DEPWEHRGKYWNANGIAPMFEGLMRRHIKPYQ
MMAR_1055|M.marinum_M SYFTEGLQLMKAAWSD--EPRVRFHGRFRDVD--------DLPIQPKPVQ
Mvan_4242|M.vanbaalenii_PYR-1 TMWEEALEVSIRCMTE--APFTGFKGEHVEMA--------ARNVIPKPLQ
MAB_4628c|M.abscessus_ATCC_199 EYLQENYELLRRLLR---EEHVDWVGVHRHPLA-------DATTLPRPYD
TH_3375|M.thermoresistible__bu RRLDDLINVLRQAWS---GKPVEHHGLGTYKT---------PPVTPLPFQ
MSMEG_4092|M.smegmatis_MC2_155 RIFNDVVDRLHDVLDG---HVLNSVGETLHPPG------------AGVRR
MLBr_00269|M.leprae_Br4923 ARLRESVRLMRELWRG---DRVDFDGDYYQLKG----------ASIYDVP
Rv3618|M.tuberculosis_H37Rv WPYPEIATAAMIS-PSGPRLAGALGTSLLSLSMSVP-GGYAALETAWGVV
MUL_4194|M.ulcerans_Agy99 WPYPEISTAAMIS-PSGPRLAGSLGTSLLSLSMSVP-GGYAALENTWQVL
Mflv_4429|M.gilvum_PYR-GCK EPCFDIAVAASFS-PTGPRGAGRHGIGMLSIAATAR-QGMDLLAQHWNTW
MAV_2779|M.avium_104 DGGIPLAVAAVAS-PTGARLAGKHGIGLLSIGATLTVEGFNALSYHWGIV
Mb1971|M.bovis_AF2122/97 KPHPPIGVTGFSAGSETLKLAGERGYIPMSLDLNTE-----YVATHWDAV
MMAR_1055|M.marinum_M RPHPPIWFGGRAP--KALARAVRHGDAFLGAGSSTT----ADFATAVTTL
Mvan_4242|M.vanbaalenii_PYR-1 QPHPPVWVACTRP--SSVQMAAQKAIGALSFAYTGPEALKERVDGYYKEF
MAB_4628c|M.abscessus_ATCC_199 GPFRIWHGSATST--FAVELAAKWGDPIVTANALQP---KENYRVLIDRY
TH_3375|M.thermoresistible__bu QDGPPVLVGAFAE--AGLRRAVRLGNGWLAP-----------ELRHWRGL
MSMEG_4092|M.smegmatis_MC2_155 RLWQAITSDAVHSGPAAVRAATAGDGLQLSRATAWQ---GGSVEDAQIRQ
MLBr_00269|M.leprae_Br4923 EGGVPIYIAAGGP--EVAKYAGRAGEGFVCTSGKGE---ELYTEKLIPAV
* :
Rv3618|M.tuberculosis_H37Rv REQAAKAGRGEPDRADWRVLSIMHLSDS---RDQAIDDCTYGLPDFSR-Y
MUL_4194|M.ulcerans_Agy99 CEQAAKVGRAEPNRRDWRVLSIMHLSDTPRPGDPRLHLRAAGFLEVLRRD
Mflv_4429|M.gilvum_PYR-GCK DEVAREHG-HQADRSKWRLVGPMHLAET---REQAERDVEYGIAEFSR--
MAV_2779|M.avium_104 EERAAAFG-TQVDRTNWSLVGLFHLAET---EKQAREEVKFGIEPWFR--
Mb1971|M.bovis_AF2122/97 EEGALRSG-RTPDRRDWRLVREVLVAET---DEQAFRYAVDGTMGRAMRE
MMAR_1055|M.marinum_M RHELAEQGRDPAGFTIGKRVYLMVDDDP----ERARERVLAGLRSIYG--
Mvan_4242|M.vanbaalenii_PYR-1 EEQGAPITPAINPNILAIGGDLSMMVAKTDEEALERLGIGGGFFSFGIMH
MAB_4628c|M.abscessus_ATCC_199 RELYAHHGHDPAQLYVGAGSGGLYLADT---TEQAIAQYRPIYEARLAQM
TH_3375|M.thermoresistible__bu EKRVAALGLDSRTDPFHVAVTVNAFVAA----RDAWETVRPGVAHVAGQY
MSMEG_4092|M.smegmatis_MC2_155 SEWIAAYRDAWADPASPPRVQVSRAVYPHGDRAEALRLVTPGVRRWQS--
MLBr_00269|M.leprae_Br4923 LEGAAVAGRDADDIDKMIEIKMSYDPDP----EQALSNIRFWAPLSLAAE
.
Rv3618|M.tuberculosis_H37Rv FGAAGFVPL----ANTVEGTQSSREFVEQYAAKGNCCIGTPDDAIAHIED
MUL_4194|M.ulcerans_Agy99 FGAAGFVPL----SNATDGAEGTREFAEDYAAKGNCCIGTPEDEIAYIED
Mflv_4429|M.gilvum_PYR-GCK --YFTHILP----SGPVQG-DTPEEIIANNRQSGFAVIGTPDDAIAKISE
MAV_2779|M.avium_104 -YFQKVAAF----PQMTMPGDQLDEMIDVINENGAGVIGTPERAREQVQR
Mb1971|M.bovis_AF2122/97 YVLPTFRMFGMTKFYKHNPSVPDDEVTPEYLAENTFVVGSVQTVVDKLEA
MMAR_1055|M.marinum_M ---------------------------KMGGLDAVAVAGTPDDVTRGLAE
Mvan_4242|M.vanbaalenii_PYR-1 YYLTGMHTPG-RTGVWELYEKAVKEDPTLAYGPGRGAIGSPDTVREFLRG
MAB_4628c|M.abscessus_ATCC_199 AKLKAHPKA--------VGKFPSFESIEDAADRGPVLAGSPERVAEKILD
TH_3375|M.thermoresistible__bu RSWLVESGD-----LPALEGKEFEYEADETGKPPQFVAGTPEQCVAQLRP
MSMEG_4092|M.smegmatis_MC2_155 --------------WSTHGDPRQTETVDEYLTADRALIGPGAELADELAS
MLBr_00269|M.leprae_Br4923 QKHSIDDP--------IEMEKVADALPIEQVAKRWIVVSDPDEAVARVGQ
. :
Rv3618|M.tuberculosis_H37Rv LLHRS----GGFGTLLLLGHDWAP--PPATFHSYELFARAVIPYFKG---
MUL_4194|M.ulcerans_Agy99 LLNRS----GGFGTLLLLGHDWAS--PQATFHSYDLFARKVIPYFKG---
Mflv_4429|M.gilvum_PYR-GCK LVEASD---GGFGAFLLFDHDWAP--PAAKLRSYELFAQYVIPHFTG---
MAV_2779|M.avium_104 CWDQS----GGFGCMLQMGHEWAN--PAATKRSAELFAAEVMPHFQG---
Mb1971|M.bovis_AF2122/97 TYDQV----GGFGHLLILGFDYSDN-PGPWKESLRLLAHEVMPRLNA---
MMAR_1055|M.marinum_M VIAAG--------AQTLLLNPVGPD-VGQNHEQMERLAAEVIPRLR----
Mvan_4242|M.vanbaalenii_PYR-1 YEASG------VDEIILLLNPRSH---EGTMESIEIMGRDILPEFIERDE
MAB_4628c|M.abscessus_ATCC_199 WHEAFG---HEFQSISLSPEADFE----EQKDTLRRFAEEVVPLVRA---
TH_3375|M.thermoresistible__bu WWRILARLPEHVQPHLILGMTFPGVSREATFESVRLLAREVVPALNAEE-
MSMEG_4092|M.smegmatis_MC2_155 DPALR------HASDLLLSFVPGVPEHGEHLRLLEDTARELVPRLGWYP-
MLBr_00269|M.leprae_Br4923 YVTWG-------LNHLVFHAPGHN-----QRRFLELFEKDLAPRLRRLG-
: * .
Rv3618|M.tuberculosis_H37Rv --------QLAAPRASHEWARGKRDQLIGRAGEAVVKAITEHVAEQ----
MUL_4194|M.ulcerans_Agy99 --------QLEAPRASHEWARDKREDLIGRAGQAVVAAITEHVARFSSLR
Mflv_4429|M.gilvum_PYR-GCK --------QLSAPIASRDWVTESGRVFVDQATHAIGRAIESHAAEQ----
MAV_2779|M.avium_104 --------QAQPTLDAAARAGQARDSLAQSQLDAVAHMTKKYQGEV----
Mb1971|M.bovis_AF2122/97 --------RLATKPATAVV-------------------------------
MMAR_1055|M.marinum_M --------------------------------------------------
Mvan_4242|M.vanbaalenii_PYR-1 KAVKDKAKRLEPVIEKVEARRQSWDAPLFDETYAFGGLPTGRGGKFTAGE
MAB_4628c|M.abscessus_ATCC_199 --------EVKSTLWGPLDTRRAKGFTAA---------------------
TH_3375|M.thermoresistible__bu --------------------------------------------------
MSMEG_4092|M.smegmatis_MC2_155 ----------STGVS-----------------------------------
MLBr_00269|M.leprae_Br4923 --------------------------------------------------
Rv3618|M.tuberculosis_H37Rv ----------GEAGS-----------------------------------
MUL_4194|M.ulcerans_Agy99 SPVTPTSRHVGLAGGRRARHHPGMKPISGRGRRGGEAARGCAMSRQAAKD
Mflv_4429|M.gilvum_PYR-GCK -----------QAKQSRTSD------------------------------
MAV_2779|M.avium_104 -----------ESK------------------------------------
Mb1971|M.bovis_AF2122/97 --------------------------------------------------
MMAR_1055|M.marinum_M --------------------------------------------------
Mvan_4242|M.vanbaalenii_PYR-1 IPEAMAEINEGRVKAAQAEKDAKAAKEAAS--------------------
MAB_4628c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3375|M.thermoresistible__bu --------------------------------------------------
MSMEG_4092|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_00269|M.leprae_Br4923 --------------------------------------------------
Rv3618|M.tuberculosis_H37Rv --------------------------------------------------
MUL_4194|M.ulcerans_Agy99 MLAGVGGRGGSGNGAERNGCNAAQPGHRTRPSVGYRQTPDLGGPANPPET
Mflv_4429|M.gilvum_PYR-GCK --------------------------------------------------
MAV_2779|M.avium_104 --------------------------------------------------
Mb1971|M.bovis_AF2122/97 --------------------------------------------------
MMAR_1055|M.marinum_M --------------------------------------------------
Mvan_4242|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4628c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3375|M.thermoresistible__bu --------------------------------------------------
MSMEG_4092|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_00269|M.leprae_Br4923 --------------------------------------------------
Rv3618|M.tuberculosis_H37Rv --------------------------------------------------
MUL_4194|M.ulcerans_Agy99 TRHARQRQFRQRLWQGLDRLGGFLARVRGSREETVGQTVDVFQRRGGEPE
Mflv_4429|M.gilvum_PYR-GCK --------------------------------------------------
MAV_2779|M.avium_104 --------------------------------------------------
Mb1971|M.bovis_AF2122/97 --------------------------------------------------
MMAR_1055|M.marinum_M --------------------------------------------------
Mvan_4242|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4628c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3375|M.thermoresistible__bu --------------------------------------------------
MSMEG_4092|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_00269|M.leprae_Br4923 --------------------------------------------------
Rv3618|M.tuberculosis_H37Rv ----------
MUL_4194|M.ulcerans_Agy99 GRNQPDIGVR
Mflv_4429|M.gilvum_PYR-GCK ----------
MAV_2779|M.avium_104 ----------
Mb1971|M.bovis_AF2122/97 ----------
MMAR_1055|M.marinum_M ----------
Mvan_4242|M.vanbaalenii_PYR-1 ----------
MAB_4628c|M.abscessus_ATCC_199 ----------
TH_3375|M.thermoresistible__bu ----------
MSMEG_4092|M.smegmatis_MC2_155 ----------
MLBr_00269|M.leprae_Br4923 ----------