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KISLFYEFPLPRPWSEDDEHQLFQHGLDEVELADKAGFSTVWLTEHHFLEEYCHSTAPELFLAAASQRTK NIRLGFGVMHLPPPINHPARIAERVATLDHLSNGRVEYGTGEGSSVAELGGFNIDPADKRTMWEEALEVS IRCMTEAPFTGFKGEHVEMAARNVIPKPLQQPHPPVWVACTRPSSVQMAAQKAIGALSFAYTGPEALKER VDGYYKEFEEQGAPITPAINPNILAIGGDLSMMVAKTDEEALERLGIGGGFFSFGIMHYYLTGMHTPGRT GVWELYEKAVKEDPTLAYGPGRGAIGSPDTVREFLRGYEASGVDEIILLLNPRSHEGTMESIEIMGRDIL PEFIERDEKAVKDKAKRLEPVIEKVEARRQSWDAPLFDETYAFGGLPTGRGGKFTAGEIPEAMAEINEGR VKAAQAEKDAKAAKEAAS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4242 | - | - | 100% (439) | luciferase family protein |
| M. vanbaalenii PYR-1 | Mvan_4004 | - | 3e-20 | 27.22% (371) | luciferase family protein |
| M. vanbaalenii PYR-1 | Mvan_1925 | - | 9e-18 | 31.35% (185) | luciferase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1971 | - | 1e-18 | 27.27% (352) | monooxygenase |
| M. gilvum PYR-GCK | Mflv_2404 | - | 0.0 | 95.89% (438) | luciferase family protein |
| M. tuberculosis H37Rv | Rv3618 | - | 4e-22 | 26.69% (341) | monooxygenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0527c | - | 5e-28 | 29.11% (347) | monooxygenase |
| M. marinum M | MMAR_4774 | - | 0.0 | 80.56% (432) | monoxygenase |
| M. avium 104 | MAV_0881 | - | 0.0 | 82.57% (436) | hypothetical protein MAV_0881 |
| M. smegmatis MC2 155 | MSMEG_4863 | - | 0.0 | 92.47% (438) | hypothetical protein MSMEG_4863 |
| M. thermoresistible (build 8) | TH_3770 | - | 0.0 | 89.52% (439) | PUTATIVE luciferase family protein |
| M. ulcerans Agy99 | MUL_0345 | - | 0.0 | 80.09% (432) | monoxygenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_4242|M.vanbaalenii_PYR-1 MKIS--LFYEFPLPRPWSEDDEHQLFQHGLDEVELADKAGFSTVWLTEHH
Mflv_2404|M.gilvum_PYR-GCK MKIS--LFYEFPLPRPWSDDDEHQLFQHGLDEVELADKAGFSTVWLTEHH
MSMEG_4863|M.smegmatis_MC2_155 MKIS--LFYEFPLPRPWSEDDEHQLFQHGLDEVELADKAGFSTVWLTEHH
TH_3770|M.thermoresistible__bu MKIS--LFYEFPLPRPWSEDDEHKLFQDGLDEVEAADKAGFSSVWLTEHH
MMAR_4774|M.marinum_M MKIS--LFYEFALPRPWAPDDERIMLQDCLDEVEAADKAGFSTVWLTEHH
MUL_0345|M.ulcerans_Agy99 MKIS--LFYEFALPRPWAPNDERIMLQDCLDEVEAADKAGFSTVWLTEHH
MAV_0881|M.avium_104 MKIS--LFYEFALPRPWAPDDEHVLLQECLDEVEAADKAGFSTVWLTEHH
Rv3618|M.tuberculosis_H37Rv MKAP-LRFGVFITPFHPTGQSPTVALQYDMERVVALDRLGYDEAWFGEHH
MAB_0527c|M.abscessus_ATCC_199 MSAPPLRFGAFITPFHPVGQNPTTALEYDLDRVVALDRLGYHEAWFGEHH
Mb1971|M.bovis_AF2122/97 MEIG-----IFLMPAHPPERTLYDATRWDLDVIELADQLGYVEAWVGEHF
*. * * . :: : *: *: .*. **.
Mvan_4242|M.vanbaalenii_PYR-1 FLEEYCHSTAPELFLAAASQRTKNIRLGFGVMHLPPPINHPARIAERVAT
Mflv_2404|M.gilvum_PYR-GCK FLEEYCHSTAPELFLAAASQRTKNIRLGFGVMHLPPPINHPARIAERVAT
MSMEG_4863|M.smegmatis_MC2_155 FLEEYCHSTAPEMFLAAASQRTENIRLGFGVMHLPPPINHPARIAERVAT
TH_3770|M.thermoresistible__bu FLEEYCHSTAPEMFLAAASQRTENIRLGFGVMHLPPPINHPARIAERVAT
MMAR_4774|M.marinum_M FLEEYCHSTAPEIFLAAASQRTKNIRLGFGIMHLPPAVNHPARVAERIAT
MUL_0345|M.ulcerans_Agy99 FLEEYCHSTAPEIFLAAASQRTKNIRLGFGIMHLPPAVNHPARVAERIAT
MAV_0881|M.avium_104 FLEEYCHSTAPEIFLAAASQRTENIRLGFGIMHLPPAVNHPARVAERIAT
Rv3618|M.tuberculosis_H37Rv S-GGYELIACPEVFIAAAAERTTHIRLGTGVVSLP--YHHPLMVADRWVL
MAB_0527c|M.abscessus_ATCC_199 S-GGYELISCPEVFIATAAERTKHIKLGTGVVSLP--YHHPLMVVDRWIL
Mb1971|M.bovis_AF2122/97 T-VPWEPICAPDLLLAQALLRTQQIKLAPGAHLLP--YHHPVELAHRVAY
: .*::::* * ** :*:*. * ** :** :..*
Mvan_4242|M.vanbaalenii_PYR-1 LDHLSNGRVEYGTGEGSSVAELGGFNIDP--ADKRTMWEEALEVSIRCMT
Mflv_2404|M.gilvum_PYR-GCK LDHLSNGRVEFGTGEGSSVAELGGFNIDP--ADKRAQWEEALEVSIRCMT
MSMEG_4863|M.smegmatis_MC2_155 LDHLSNGRVEFGTGEGSSVAELGGFNIDP--ADKRTQWEESLEVAIRCMV
TH_3770|M.thermoresistible__bu LDHLSNGRVEFGTGEGSSVAELGGFNIDP--ADKRTMWEEALEVSIRCMI
MMAR_4774|M.marinum_M LDLLSNGRVEFGTGESSSIGELGGFNIDP--ADKRGQWEEALEVAIRCMI
MUL_0345|M.ulcerans_Agy99 LDLLSNGRVEFGTGESSSIGELGGFNIDP--TDKRGQWEEALEVAIRCMI
MAV_0881|M.avium_104 LDLLSNGRVEFGTGESSSVGELGGFNIDP--ADKRAQWEEALEVAIRCMV
Rv3618|M.tuberculosis_H37Rv LDHLTRGRVMFGTGPGALPSDAYMMGIDP--VEQRRMMQESLEAILALFR
MAB_0527c|M.abscessus_ATCC_199 LDHITRGRVIFGTGPGALPTDAYMMGIDP--VDQRRMQEESLEAILALLR
Mb1971|M.bovis_AF2122/97 FDHLAQGRFMLGVGASGIPGDWALYDVDGKNGEHREMTREALEIMLRIWT
:* ::.**. *.* .. : .:* ::* .*:** :
Mvan_4242|M.vanbaalenii_PYR-1 EAPFTGFK--GEHVEMA--------ARNVIPKPLQQPHPPVWVACTR--P
Mflv_2404|M.gilvum_PYR-GCK EAPFTGFK--GEHVEMP--------ARNVIPKPLQQPHPPVWVACTR--P
MSMEG_4863|M.smegmatis_MC2_155 EEPFSGFK--GEHVEMP--------ARNVIPKPLQKPHPPVWVACTR--P
TH_3770|M.thermoresistible__bu EEPFSGFK--GEHVEMP--------ARNVIPKPLQKPHPPVWVACTR--P
MMAR_4774|M.marinum_M EEPFAGFT--GDHIQMP--------ARNVIPKPMQKPHPPVWVACTR--P
MUL_0345|M.ulcerans_Agy99 EEPFAGFT--GDHIQMP--------ARNVIPKPMQKPHPPVWVACTR--P
MAV_0881|M.avium_104 EEPFSGFH--GEHVQMP--------ARNVIPKPLQKPHPPVWVACTR--P
Rv3618|M.tuberculosis_H37Rv AAPDERIDRHSDWFTLR--------EAQLHIRPYTWPYPEIATAAMIS-P
MAB_0527c|M.abscessus_ATCC_199 ATPQERINRETSWFTLR--------DAQLQLRPYTHPYPEILTAAMFS-P
Mb1971|M.bovis_AF2122/97 EDEPWEHR--GKYWNANGIAPMFEGLMRRHIKPYQKPHPPIGVTGFSAGS
. . :* *:* : .: .
Mvan_4242|M.vanbaalenii_PYR-1 SSVQMAAQKAIGALSFAYTGPEALKERVDGYYKEFEEQGAPITPAINPNI
Mflv_2404|M.gilvum_PYR-GCK SSVGMAAEKAIGALSFAYTGPEALKDRVDGYYKDFEEKGTPITPAINPNL
MSMEG_4863|M.smegmatis_MC2_155 SSVQMAAQKAIGALSFAYTGPEALKERVAGYYKEFEEQGAPVTPAINPNI
TH_3770|M.thermoresistible__bu SSVQMAAQKAIGALSFAYTGPGPLKERVDGYYKEFEEKGSPVTPAVNPNI
MMAR_4774|M.marinum_M ATVQMAAQKCIGALSFAYTGPGPLTERVNGYYKEFEENGTPVTPAINPNI
MUL_0345|M.ulcerans_Agy99 ATVQMAAQKCIGALSFAYTGPGPLTERVNGYYKEFEENGTPVTPAINPNI
MAV_0881|M.avium_104 ASVQMAAQKAIGALSFAYTGPGPLTERVNGYYKEFEENGVPVTPAINPNI
Rv3618|M.tuberculosis_H37Rv SGPRLAGALGTSLLSLSMSVPGGYAALETAWGVVREQAAKAGRGEPDRAD
MAB_0527c|M.abscessus_ATCC_199 SGPRLAGKLGAGLLSLSASIPGGFAALENAWEVVREQAEIHGHPEPDRSS
Mb1971|M.bovis_AF2122/97 ETLKLAGERGYIPMSLDLN-----TEYVATHWDAVEEGALRSGRTPDRRD
:*. :*: . *: :
Mvan_4242|M.vanbaalenii_PYR-1 LAIGGDLSMMVAKTDEEALERLG-IGGGFFSFGIMHYYLTGMHTPGRTG-
Mflv_2404|M.gilvum_PYR-GCK LAIGGDLSMMVAKTDEEALKRLG-IGGGFFSFGIMHYYLTGMHTPGRTG-
MSMEG_4863|M.smegmatis_MC2_155 LAIGGDLSMMVARTDEEALKRLG-IGGGFFSFGIMHYYLTGMHTPGRTK-
TH_3770|M.thermoresistible__bu LAIGGDLSMMVAKTDEEALKRLG-IGGGFFSFGIMHYYMTGMHTPGRTG-
MMAR_4774|M.marinum_M LAIGGDLSMMVAKTDEQALQRLG-QGGGFFSFGIMHYYMTGIHTPGRTG-
MUL_0345|M.ulcerans_Agy99 LAIGGDLSMMVAKTDEQALQRLG-QGGGFFSFGIMHYYMTGIHTPGRTG-
MAV_0881|M.avium_104 LAIGGDLSMMVAKTDEEALQRLG-KGGGFFSFGIMHYYMTGVHTPGRTG-
Rv3618|M.tuberculosis_H37Rv WRVLSIMHLSDSRDQAIDDCTYG-LPDFSRYFGAAGFVPLANTVEGTQ--
MAB_0527c|M.abscessus_ATCC_199 WRVLGIMHLAETRDQAIADCTYG-LPDYAHYFGAVGVLPLANSADGADGA
Mb1971|M.bovis_AF2122/97 WRLVREVLVAETDEQAFRYAVDGTMGRAMREYVLPTFRMFGMTKFYKHNP
: : : : : * : .
Mvan_4242|M.vanbaalenii_PYR-1 --VWELYEKAVKEDPTLAYGPGRGAIGSPDTVREFLRGYEASGVDEIILL
Mflv_2404|M.gilvum_PYR-GCK --VWELYEKAVKEDPTLAYGPGRGAIGSPETVREFLRGYEASGVDEIILL
MSMEG_4863|M.smegmatis_MC2_155 --VWERYEQAVADDPTLAYGPGRGAIGSPETVREFLRGYEASGVDEIILL
TH_3770|M.thermoresistible__bu --VWELYEQAVKEDPTLAYGPGRGAIGSPETVREFLRGYEESGVDEIILL
MMAR_4774|M.marinum_M --VWTRYLEEIEKDPTLAYGPGRGAIGCPATVREFLRGYEESGVDEIILL
MUL_0345|M.ulcerans_Agy99 --VWTRYLEEIEKDPTLAYGPGRGAIGCPATVREFLRGYEESGVDEIILL
MAV_0881|M.avium_104 --VWKRYLEEVEKDPTLAYGPGRGAIGSPATVREFLRGYEESGVDEIILL
Rv3618|M.tuberculosis_H37Rv --SSREFVEQYAAKGNCCIGTPDDAIAHIEDLLHRSGGFG----TLLLLG
MAB_0527c|M.abscessus_ATCC_199 -IDPHEFVKAYADEGNCCIGTPEDAIEYIQGLLDTSGGFG----TFLMLG
Mb1971|M.bovis_AF2122/97 SVPDDEVTPEYLAENTFVVGSVQTVVDKLEATYDQVGGFG----HLLILG
. . *. .: . *: ::*
Mvan_4242|M.vanbaalenii_PYR-1 LNPRSHEGTMES-IEIMGRDILPEFIERDEKAVKDKAKRLEPVIEKVEAR
Mflv_2404|M.gilvum_PYR-GCK LNPRSHEGTMES-IEIMGRDILPEFIERDEKAVKDKAKRLEPVIEKVEAR
MSMEG_4863|M.smegmatis_MC2_155 LNPRSHEGTMES-IEIMGKEILPEFIERDEKAVKDKAERLEPVVEKVESR
TH_3770|M.thermoresistible__bu LNPRSHEGTMES-IEIMGREILPEFIEREEKAQVEKAKRLEPVLEKVEAR
MMAR_4774|M.marinum_M LNPRSHEGTMES-IELMGKEVLPEFIERDAKAVADKAVRLAPAIEKVQAR
MUL_0345|M.ulcerans_Agy99 LNPRSHEGTMES-IELMGKEVLPEFIERDAKAVADKAVRLAPAIEKVQAR
MAV_0881|M.avium_104 LNPRSHEGTMES-IELMGKEVLPEFIERDAKAVADKATRLAPVIEKVEAR
Rv3618|M.tuberculosis_H37Rv HDWAPPPATFHS-YELFARAVIPYFKG--------QLAAPRASHEWARGK
MAB_0527c|M.abscessus_ATCC_199 HDWAAPEATFKS-YELFARKVIPHFTG--------QLTAAQASHDWAQAK
Mb1971|M.bovis_AF2122/97 FDYSDNPGPWKESLRLLAHEVMPRLNAR---------LATKPATAVV---
: .. .. .::.: ::* : . .
Mvan_4242|M.vanbaalenii_PYR-1 RQSWDAPLFDETYAFGGLPTGRGGKFTAGEIPEAMAEINEGRVKAAQAEK
Mflv_2404|M.gilvum_PYR-GCK RQSWDAPMFDETYSFGGLPTGRGGKFTAGEIPEAMAEINEGRVKAAQAEK
MSMEG_4863|M.smegmatis_MC2_155 RQGSDAPLFDETYAFGGLPTGRGGKFTAGEIPEAMAEINEGRVKAAQAEK
TH_3770|M.thermoresistible__bu RKPSEAPEFDETYSFGGLPTGRGGKFTASEIPEAMAEINEGRVQAAKKAK
MMAR_4774|M.marinum_M RQESNAPQFDEAYSFGGLPTGRGGKFTASEIPEAMAEINEGRVQAAQRLK
MUL_0345|M.ulcerans_Agy99 RQESNAPQFDEAYSFGGLPTGRGGKFTASEIPEAMAEINEGRVQAAQRLK
MAV_0881|M.avium_104 RPKSTAPQFDENYSFGGLPTGRGGKFTASEIPEAMAEINEGRVQAAQRAK
Rv3618|M.tuberculosis_H37Rv R---------------DQLIGRAGEAVVKAITEHVAEQGEAGS-------
MAB_0527c|M.abscessus_ATCC_199 R---------------GELLGRAGDAVAKAIGEHVAQKASH---------
Mb1971|M.bovis_AF2122/97 --------------------------------------------------
Mvan_4242|M.vanbaalenii_PYR-1 DAKAAKEAAS---
Mflv_2404|M.gilvum_PYR-GCK DARAAKEAAG---
MSMEG_4863|M.smegmatis_MC2_155 ---AAREAAG---
TH_3770|M.thermoresistible__bu ------EQAS---
MMAR_4774|M.marinum_M ------EQRK---
MUL_0345|M.ulcerans_Agy99 ------EQRK---
MAV_0881|M.avium_104 ------EQQQQKK
Rv3618|M.tuberculosis_H37Rv -------------
MAB_0527c|M.abscessus_ATCC_199 -------------
Mb1971|M.bovis_AF2122/97 -------------