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DESTAAWIADGFVGQRMLAVPRPVVDHALGAPVTRRLLVTDAGFFPRATRHGRSRSRGATEHVVMVCTAG AGWCRTEEGAFDVGVGDAVLLPKGRAHMYGAAESDPWTLWWMHVTGSDSAELIAAARVSPVSPVVHLVDP APATSLISQVIDMLADASTTAGLIGAAGAAWHALTVIAATGRQRSTGEADPVDRALEHLRSTSPRRTDVA ALAAIVGLSTSHLNALFRQRTGIGPLEFQQQLRMSRARELLDTTTLTIAAVARAAGFNDPLYFSRQFAKV HGQSPSAYRQRHQN*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3998 | - | - | 100% (295) | MmsAB operon regulatory protein |
| M. smegmatis MC2 155 | MSMEG_4655 | - | 2e-10 | 28.77% (146) | transcriptional regulator, AraC family protein |
| M. smegmatis MC2 155 | MSMEG_3365 | - | 6e-10 | 36.59% (82) | transcriptional regulator, AraC family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1350c | alkAb | 3e-08 | 33.98% (103) | methylated-DNA--protein-cysteine methyltransferase |
| M. gilvum PYR-GCK | Mflv_1008 | - | 2e-09 | 31.50% (127) | Fis family transcriptional regulator |
| M. tuberculosis H37Rv | Rv1317c | alkA | 2e-08 | 32.46% (114) | bifunctional methylated-DNA--protein-cysteine |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1313 | - | 3e-10 | 34.38% (96) | AraC family transcriptional regulator |
| M. marinum M | MMAR_1063 | - | 2e-13 | 46.15% (78) | transcriptional regulatory protein |
| M. avium 104 | MAV_1537 | - | 9e-09 | 32.46% (114) | transcriptional regulator, AraC family protein |
| M. thermoresistible (build 8) | TH_4270 | - | 2e-10 | 33.93% (112) | PUTATIVE putative transcriptional regulator, AraC family |
| M. ulcerans Agy99 | MUL_0821 | - | 1e-13 | 46.15% (78) | transcriptional regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_5518 | - | 5e-12 | 43.42% (76) | response regulator receiver protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1063|M.marinum_M --------------------------------------------------
MUL_0821|M.ulcerans_Agy99 --------------------------------------------------
Mvan_5518|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1350c|M.bovis_AF2122/97 --------------------------------------------------
Rv1317c|M.tuberculosis_H37Rv MHDDFERCYRAIQSKDARFDGWFVVAVLTTGVYCRPSCPVRPPFARNVRF
MAV_1537|M.avium_104 MHDDFERCYRAVQSKDARFDGWFVTAVLTTGIYCRPSCPVRPPFARNVRF
Mflv_1008|M.gilvum_PYR-GCK --------------------------------------------MTDEFR
MSMEG_3998|M.smegmatis_MC2_155 --------------------------------------------------
MAB_1313|M.abscessus_ATCC_1997 --------------------------------------------------
TH_4270|M.thermoresistible__bu --------------------------------------------------
MMAR_1063|M.marinum_M -----------------------------------MAQAARLIQH----R
MUL_0821|M.ulcerans_Agy99 -----------------------------MDYLWRMAQAARLIQH----R
Mvan_5518|M.vanbaalenii_PYR-1 -----------------------------------MSETAVFAGR----R
Mb1350c|M.bovis_AF2122/97 ------------------------------MRSDVVARAMRLIADGTVDR
Rv1317c|M.tuberculosis_H37Rv LPTAAAAQGEGFRACKRCRPDASPGSPEWNVRSDVVARAMRLIADGTVDR
MAV_1537|M.avium_104 YPTAAAAQRAGFRACKRCRPDASPGSPEWNVRGDVVARTMRLIADGTVDR
Mflv_1008|M.gilvum_PYR-GCK HNADPGGKTVVFALYDKVTLQDVAAPMEIFARANDFGASYRVLTVSPSGR
MSMEG_3998|M.smegmatis_MC2_155 ----------------------------------MDESTAAWIADGFVGQ
MAB_1313|M.abscessus_ATCC_1997 --------------------------------------------------
TH_4270|M.thermoresistible__bu ---------------------MKDGPLLELGRVRDRDQIRAAVADIFCPH
MMAR_1063|M.marinum_M SGVP----IYGY-RTDPDIPRVSVLRPGPEDLG-----DRARHIHDFPAL
MUL_0821|M.ulcerans_Agy99 SGVP----IYGY-RTDPDIPRVSVRRPGPEDLG-----DRARHIHDFPAL
Mvan_5518|M.vanbaalenii_PYR-1 DGTP----VYAYPRRRPQAP-VSVLELGPDAPP-----VRTTHIHEFPVL
Mb1350c|M.bovis_AF2122/97 DGVSGLAAQLGYTIRQLERLLQAVVGAGPLALARAQRMQTARVLIETTNL
Rv1317c|M.tuberculosis_H37Rv DGVSGLAAQLGYTIRQLERLLQAVVGAGPLALARAQRMQTARVLIETTNL
MAV_1537|M.avium_104 DGVGGLAARLGYTTRQLERLLQAEVGAGPLALARAQRAQTARVLIETTEL
Mflv_1008|M.gilvum_PYR-GCK PVGTTAFATLNVDVALDAAPDAFDTLLVPGGVP--ADFSFTPGLHDIPEE
MSMEG_3998|M.smegmatis_MC2_155 RMLAVPRPVVDHALGAPVTRRLLVTDAGFFPRATRHGRSRSRGATEHVVM
MAB_1313|M.abscessus_ATCC_1997 -------MVFGGFGGVALGELQITFVSEPIVEP------TEWYFDEPHHV
TH_4270|M.thermoresistible__bu GLDVRKGSGLDASVRAQAAGSIKLVWVTYGAPVRIDVPPPSEPFHLVQIP
MMAR_1063|M.marinum_M WYVPAAGLVYIAAAGQVLEPTQFGSLQGGVAMFFDPAALGGDGG-SPWPS
MUL_0821|M.ulcerans_Agy99 WYVPAAGLVYIAAAGQVLEPTQFGSLQAGVAMFFDPAALGGDGG-SPWPS
Mvan_5518|M.vanbaalenii_PYR-1 VYQPATGSVDVVAAGLPVDPGRGGDRTGAVAVFFDPAALGEGAR-SPWPT
Mb1350c|M.bovis_AF2122/97 PFGDVAFAAGFSSIRQFNDTVRLACDGTPTALRARAAARFESATASAGTV
Rv1317c|M.tuberculosis_H37Rv PFGDVAFAAGFSSIRQFNDTVRLACDGTPTALRARAAARFESATASAGTV
MAV_1537|M.avium_104 PFGDVAFAAGFSSIRQFNDTVRAVFESPPSVLRRRAAARCASTANSPGAV
Mflv_1008|M.gilvum_PYR-GCK PTPDSVADACDMVRRLAPRARRIASVCTGSFVLAALGLLDGRRATTHWAH
MSMEG_3998|M.smegmatis_MC2_155 VCTAGAGWCRTEEGAFDVGVGDAVLLPKGRAHMYGAAESDPWTLWWMHVT
MAB_1313|M.abscessus_ATCC_1997 VAVYQGGRILSKEIDFVDGLSRRYLPKVGDVLVVPMGSRAAITTQGERAS
TH_4270|M.thermoresistible__bu LQGYLSVTSGDEEVVSDSALASMPDPRLPCTMRWEAHCSEVIVRIDDDVL
MMAR_1063|M.marinum_M WRTHPLLFPF-LHGHSGGILRLEVP-----------AARRSTWDGAIAAI
MUL_0821|M.ulcerans_Agy99 WRTHPLLFPF-LHGHSGGILRLEVP-----------AARRSTWDGAIAAI
Mvan_5518|M.vanbaalenii_PYR-1 WRAHPLLSPF-LHGHHDGILRLEVP-----------AARRPFWDAGVAAL
Mb1350c|M.bovis_AF2122/97 SLRLPVRAPFAFEGVFGHLAATAVPGCEEVRDGAYRRTLRLPWGNGIVSL
Rv1317c|M.tuberculosis_H37Rv SLRLPVRAPFAFEGVFGHLAATAVPGCEEVRDGAYRRTLRLPWGNGIVSL
MAV_1537|M.avium_104 CLRLPVRTPFGFQGVFGHLAASVVPGCEEVRDGAYRRTLRLGFGTGIVTL
Mflv_1008|M.gilvum_PYR-GCK CQTLARQYPAVMVDPD-SLFVQDGP--------------FITGAGITAGI
MSMEG_3998|M.smegmatis_MC2_155 GSDSAELIAAARVSPVSPVVHLVDP------------APATSLISQVIDM
MAB_1313|M.abscessus_ATCC_1997 FCRFDIPTRLLDQRDLQPRVAYSDP-------------LILQLASRMYSV
TH_4270|M.thermoresistible__bu HRHLESLLGHPVKAPLHFSLGMPLD-----------SGPGSSWRAAIDMM
:
MMAR_1063|M.marinum_M EAELTARQ--QGYGQAVAAHLTLLLIELARLAR-----DVVGDLRRSGEP
MUL_0821|M.ulcerans_Agy99 EAELTTRQ--QGYGQAVTAHLTLLLIELARLAR-----DVVGDLRRSGEP
Mvan_5518|M.vanbaalenii_PYR-1 QAELTDRR--DGYAQAALAHLTVLLIELARLSD-----DVVGDLRRSNEP
Mb1350c|M.bovis_AF2122/97 TPAPDHVR--CLLVLDDFRDLMTATARCRRLLDLDADPEAIVEALGADPD
Rv1317c|M.tuberculosis_H37Rv TPAPDHVR--CLLVLDDFRDLMTATARCRRLLDLDADPEAIVEALGADPD
MAV_1537|M.avium_104 TPAADHVR--CELVLDDFRDLTAAIARCRRLLDLDADPEAVDEAVAADPQ
Mflv_1008|M.gilvum_PYR-GCK DLALAMVE--SDFGPAVARRVARWMVVFLQRPGGQAQFSVWAESALPVTG
MSMEG_3998|M.smegmatis_MC2_155 LADASTTA--GLIGAAGAAWHALTVIAATGRQR-----------STGEAD
MAB_1313|M.abscessus_ATCC_1997 ADRTDVIA--RLLRESLADVVRLHLSDHYAALR-----PRPERRRLLDSA
TH_4270|M.thermoresistible__bu ITELDRDGGLLKFPLVSAQLESLILTGLLTAQPHNYTTALLADSGPAPPR
MMAR_1063|M.marinum_M LLAEVFEVIDRRHAEPLSLRDVAAEVGMTPGHLTTIVRRRTGRTVQEW--
MUL_0821|M.ulcerans_Agy99 LLAEVFEVIDRRHAEPLSLRDVAAEVGMTPGHLTTIVRRRTGRTVQEW--
Mvan_5518|M.vanbaalenii_PYR-1 LLAQVFDVIERRLGEPLTLRDVARECGLTAGYLTTVVRRRTGRTVGSW--
Mb1350c|M.bovis_AF2122/97 LRAVVGKAPGQRIPRTVDEAEFAVRAVLAQQVSTKAASTHAGRLVAAYGR
Rv1317c|M.tuberculosis_H37Rv LRAVVGKAPGQRIPRTVDEAEFAVRAVLAQQVSTKAASTHAGRLVAAYGR
MAV_1537|M.avium_104 LAPAVRKAPGQRIPRTVDEAELAVRAVLGQQVSIRAARTHAGRLVAAYGR
Mflv_1008|M.gilvum_PYR-GCK GLRAVVDSVIADPAGDHSLAAMASRAAVSERHLVRVFRDQVGMTPARF--
MSMEG_3998|M.smegmatis_MC2_155 PVDRALEHLRSTSPRRTDVAALAAIVGLSTSHLNALFRQRTGIGPLEF--
MAB_1313|M.abscessus_ATCC_1997 MQARVTEYIEDGLDADISLSALAGHAQMSTSEFRKAFTEVFGHTPYQF--
TH_4270|M.thermoresistible__bu AIRRALDYIESESDRAITTARLAAHVGISARALQRGFQEHVGCSPMDY--
. . .* : * :
MMAR_1063|M.marinum_M -------------------------------IIERRMAQARELLVATDLA
MUL_0821|M.ulcerans_Agy99 -------------------------------IIERRMAQARELLVATDLA
Mvan_5518|M.vanbaalenii_PYR-1 -------------------------------IAERRMAEARALLLATELT
Mb1350c|M.bovis_AF2122/97 PVHDRHGALTHTFPSIEQLAEIDPGHLAVPKARQRTINALVASLADKSLV
Rv1317c|M.tuberculosis_H37Rv PVHDRHGALTHTFPSIEQLAEIDPGHLAVPKARQRTINALVASLADKSLV
MAV_1537|M.avium_104 AVHDPEGTLTHTFPSVQQLADVDPIHLAVPKARQRTLAALVAGLADRSIV
Mflv_1008|M.gilvum_PYR-GCK -------------------------------VEQARLEAAKVLLATGDHS
MSMEG_3998|M.smegmatis_MC2_155 -------------------------------QQQLRMSRARELLDTTTLT
MAB_1313|M.abscessus_ATCC_1997 -------------------------------VLDRRMSRAKQLLATTDLS
TH_4270|M.thermoresistible__bu -------------------------------LRDVRLRRARDLLSEADPS
: : *
MMAR_1063|M.marinum_M VG-----------------------EVARRVGISDPGYFSRLFS------
MUL_0821|M.ulcerans_Agy99 VG-----------------------EVARRVGISDPGYFSRLFS------
Mvan_5518|M.vanbaalenii_PYR-1 VG-----------------------EVGRRVGMTDPGYFTRQFR------
Mb1350c|M.bovis_AF2122/97 LDAGCDWQRARGQLLALPGVGPWTAEVIAMRGLGDPDAFPASDLGLRLAA
Rv1317c|M.tuberculosis_H37Rv LDAGCDWQRARGQLLALPGVGPWTAEVIAMRGLGDPDAFPASDLGLRLAA
MAV_1537|M.avium_104 LDTGCDWQSARTQLLALPGVGPWTAEVIAMRGLGDPDAFPAADLGLRVAA
Mflv_1008|M.gilvum_PYR-GCK QD-----------------------SVARRSGFGTPDTMRRTFR------
MSMEG_3998|M.smegmatis_MC2_155 IA-----------------------AVARAAGFNDPLYFSRQFA------
MAB_1313|M.abscessus_ATCC_1997 VT-----------------------DISVAVGFSSPSHFATTFK------
TH_4270|M.thermoresistible__bu AEVT-------------------VTEVALECGFMHLGRFSVEYR------
: *: :
MMAR_1063|M.marinum_M ------------RAHGTSPRQWRALPPRH---------------------
MUL_0821|M.ulcerans_Agy99 ------------RAHGTSPRQWRALPPRH---------------------
Mvan_5518|M.vanbaalenii_PYR-1 ------------SCHGESPRTWRARHG-----------------------
Mb1350c|M.bovis_AF2122/97 KKLGLPAQRRALTVHSARWRPWRSYATQHLWTTLEHPVNQWPPQE---KI
Rv1317c|M.tuberculosis_H37Rv KKLGLPAQRRALTVHSARWRPWRSYATQHLWTTLEHPVNQWPPQE---KI
MAV_1537|M.avium_104 KRLRLPSSQRSLTAASARWRPWRSYATQYLWTTLEHPVNHWPPQQPSKET
Mflv_1008|M.gilvum_PYR-GCK ------------RNLGISPGVYRNRFRTTGVDA-----------------
MSMEG_3998|M.smegmatis_MC2_155 ------------KVHGQSPSAYRQRHQN----------------------
MAB_1313|M.abscessus_ATCC_1997 ------------TRIGVTPTAYRSGV------------------------
TH_4270|M.thermoresistible__bu ------------RRFGESPSETLRR-------------------------
.
MMAR_1063|M.marinum_M -
MUL_0821|M.ulcerans_Agy99 -
Mvan_5518|M.vanbaalenii_PYR-1 -
Mb1350c|M.bovis_AF2122/97 A
Rv1317c|M.tuberculosis_H37Rv A
MAV_1537|M.avium_104 A
Mflv_1008|M.gilvum_PYR-GCK -
MSMEG_3998|M.smegmatis_MC2_155 -
MAB_1313|M.abscessus_ATCC_1997 -
TH_4270|M.thermoresistible__bu -