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VRSDVVARAMRLIADGTVDRDGVSGLAAQLGYTIRQLERLLQAVVGAGPLALARAQRMQTARVLIETTNL PFGDVAFAAGFSSIRQFNDTVRLACDGTPTALRARAAARFESATASAGTVSLRLPVRAPFAFEGVFGHLA ATAVPGCEEVRDGAYRRTLRLPWGNGIVSLTPAPDHVRCLLVLDDFRDLMTATARCRRLLDLDADPEAIV EALGADPDLRAVVGKAPGQRIPRTVDEAEFAVRAVLAQQVSTKAASTHAGRLVAAYGRPVHDRHGALTHT FPSIEQLAEIDPGHLAVPKARQRTINALVASLADKSLVLDAGCDWQRARGQLLALPGVGPWTAEVIAMRG LGDPDAFPASDLGLRLAAKKLGLPAQRRALTVHSARWRPWRSYATQHLWTTLEHPVNQWPPQEKIA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1350c | alkAb | - | 100% (416) | methylated-DNA--protein-cysteine methyltransferase |
| M. bovis AF2122 / 97 | Mb0147 | - | 7e-06 | 27.76% (263) | hypothetical protein Mb0147 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2326 | - | 1e-165 | 71.74% (414) | alcohol dehydrogenase |
| M. tuberculosis H37Rv | Rv1317c | alkA | 0.0 | 100.00% (416) | bifunctional methylated-DNA--protein-cysteine |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2333c | - | 1e-85 | 47.13% (401) | putative 3-methyladenine DNA glycosylase AlkA |
| M. marinum M | MMAR_4081 | alkA | 0.0 | 80.39% (413) | Ada regulatory protein AlkA |
| M. avium 104 | MAV_1537 | - | 0.0 | 79.90% (413) | transcriptional regulator, AraC family protein |
| M. smegmatis MC2 155 | MSMEG_4925 | - | 1e-176 | 73.90% (410) | transcriptional regulator, Ada family |
| M. thermoresistible (build 8) | TH_1537 | alkA | 1e-166 | 70.56% (411) | PROBABLE ADA REGULATORY PROTEIN ALKA (Regulatory protein of |
| M. ulcerans Agy99 | MUL_3945 | alkA | 0.0 | 79.66% (413) | Ada regulatory protein AlkA |
| M. vanbaalenii PYR-1 | Mvan_4322 | - | 1e-175 | 73.25% (415) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1350c|M.bovis_AF2122/97 --------------------------------------------------
Rv1317c|M.tuberculosis_H37Rv -----------------MHDDFERCYRAIQSKDARFDGWFVVAVLTTGVY
MMAR_4081|M.marinum_M -------MTLRRCNPLRVHEDFERCYRAVQSKDARFDGWFVTAVLTTRIY
MUL_3945|M.ulcerans_Agy99 -----------------MHEDFERCYRAVQSKDARFDGWFVTAVLTTRIY
MAV_1537|M.avium_104 -----------------MHDDFERCYRAVQSKDARFDGWFVTAVLTTGIY
Mflv_2326|M.gilvum_PYR-GCK -----------------MYTDFDRCYRAVQSKDTRFDGWFVTAVLTTAIY
Mvan_4322|M.vanbaalenii_PYR-1 -----------------MHTDFDRCYRAVQSKDARFDGWFVTAVLTTRIY
MSMEG_4925|M.smegmatis_MC2_155 MSLFRQWCGGAHAIVDVMHEDFDRCYRAVQSKDARFDGWFVTAVLTTGIY
TH_1537|M.thermoresistible__bu -----------------VHDDFDRCYRAVQSRDARFDGWFVTAVLTTGIY
MAB_2333c|M.abscessus_ATCC_199 -----------------MELDAEACYRAVQSRDTRFDGQFFTAVHTTGIY
Mb1350c|M.bovis_AF2122/97 -----------------------------------------------MRS
Rv1317c|M.tuberculosis_H37Rv CRPSCPVRPPFARNVRFLPTAAAAQGEGFRACKRCRPDASPGSPEWNVRS
MMAR_4081|M.marinum_M CRPSCPVRPPFARNVRFLPTAAAAQREGFRACKRCRPDASPGSPEWNVRG
MUL_3945|M.ulcerans_Agy99 CRPSCPVRPPFARNVRFLPTAAAAQREGFRACKRCRPDASPGSPEWNMRG
MAV_1537|M.avium_104 CRPSCPVRPPFARNVRFYPTAAAAQRAGFRACKRCRPDASPGSPEWNVRG
Mflv_2326|M.gilvum_PYR-GCK CRPSCPVRPPYARNMRFYPTAAAAQRAGFRACKRCRPDASPGSPEWNVRG
Mvan_4322|M.vanbaalenii_PYR-1 CRPSCPVRPPYARNMRFYPTAAAAQRAGFRACKRCRPDASPGSPEWNVRG
MSMEG_4925|M.smegmatis_MC2_155 CRPSCPVRPPLARNLRFYPTAAAAQAAGFRACKRCRPDASPGSPEWNVRG
TH_1537|M.thermoresistible__bu CRPSCPARTPLPRNVRFHPTAAAAQAAGFRPCKRCRPDASPGSPEWNVRG
MAB_2333c|M.abscessus_ATCC_199 CRPSCPAITPKRQNVSFHPTAASAQAAGYRACRRCLPDAAPGSPLWNIKS
::.
Mb1350c|M.bovis_AF2122/97 DVVARAMRLIADGTVDRDGVSGLAAQLGYTIRQLERLLQAVVGAGPLALA
Rv1317c|M.tuberculosis_H37Rv DVVARAMRLIADGTVDRDGVSGLAAQLGYTIRQLERLLQAVVGAGPLALA
MMAR_4081|M.marinum_M DIVARAMRLVADGTVDREGVTGLAARLGYTTRQLERLLQAEVGAGPLALA
MUL_3945|M.ulcerans_Agy99 DIVARAMRLVADGTVDREGVTGLAARLGYTTRQLERLLQAEVGAGPLALA
MAV_1537|M.avium_104 DVVARTMRLIADGTVDRDGVGGLAARLGYTTRQLERLLQAEVGAGPLALA
Mflv_2326|M.gilvum_PYR-GCK DVVARAMRLIADGVVDRDGVGGLAARLGYTVRQLERVTQTEVGATPLALA
Mvan_4322|M.vanbaalenii_PYR-1 DVVARAMRLITDGTVDREGVTGLAARVGYTVRQLERLMQAEVGATPLALA
MSMEG_4925|M.smegmatis_MC2_155 DVVARCMRLIADGTVDREGVTGLAARLGYTTRQLQRITQAELGASPLALA
TH_1537|M.thermoresistible__bu DVVARAMRLIADGTVDRDGVTGLAARLGYTTRQLERILQAEVGAGPLALA
MAB_2333c|M.abscessus_ATCC_199 DLAVRAMRLIGDGLVERDGVDGLSRALGYSSRQLNRVLLAELGASPLALA
*:..* ***: ** *:*:** **: :**: ***:*: : :** *****
Mb1350c|M.bovis_AF2122/97 RAQRMQTARVLIETTNLPFGDVAFAAGFSSIRQFNDTVRLACDGTPTALR
Rv1317c|M.tuberculosis_H37Rv RAQRMQTARVLIETTNLPFGDVAFAAGFSSIRQFNDTVRLACDGTPTALR
MMAR_4081|M.marinum_M RAQRMQTARVLIETTDLPFGDVAFAAGFSSIRQFNDTIRLVCDSTPTALR
MUL_3945|M.ulcerans_Agy99 RAQRMQTARVLIETTDLPFGDVAFAAGFSSIRQFNDTIRLVCDSTPTALR
MAV_1537|M.avium_104 RAQRAQTARVLIETTELPFGDVAFAAGFSSIRQFNDTVRAVFESPPSVLR
Mflv_2326|M.gilvum_PYR-GCK RAQRAQMARILIETTEMRFADAAFAAGFSSIRQFNDTVRSVSDLTPTMLR
Mvan_4322|M.vanbaalenii_PYR-1 RAQRTQMARTLIETTEMPFSDVAFAAGFSSIRQFNETIRTVCALTPSMLR
MSMEG_4925|M.smegmatis_MC2_155 RAQRAQTARVLIETTELPFSDVAFASGFASIRQFNDTVRAVCDLTPSELR
TH_1537|M.thermoresistible__bu RSQRTQTARILIETTDLAFGEVAFAAGFSSIRQFNDTVRAVFDMTPTGLR
MAB_2333c|M.abscessus_ATCC_199 RANRATTARVLIQRTDLPMSDIAFAAGFSSIRQFNDTIAAVFATTPSKLR
*::* ** **: *:: :.: ***:**:******:*: . .*: **
Mb1350c|M.bovis_AF2122/97 ARAAARFESATAS-AGTVSLRLPVRAPFAFEGVFGHLAATAVPGCEEVRD
Rv1317c|M.tuberculosis_H37Rv ARAAARFESATAS-AGTVSLRLPVRAPFAFEGVFGHLAATAVPGCEEVRD
MMAR_4081|M.marinum_M RHAAARFGAPATS-PGTVSLRLPVRTPFAYQGVFGHLAAGAVPGCEEVRD
MUL_3945|M.ulcerans_Agy99 RHAAARFGAPATS-PGTVSLRLPVRTPFAYQGVFGHLAAGAVPGCEEVRD
MAV_1537|M.avium_104 RRAAARCASTANS-PGAVCLRLPVRTPFGFQGVFGHLAASVVPGCEEVRD
Mflv_2326|M.gilvum_PYR-GCK RRARSRRGADAEGGTGELSLRLAVRTPFAFEGLFGHLAASAVPGVEEVSD
Mvan_4322|M.vanbaalenii_PYR-1 TRARARFGRDHTAGAGVMSLRLPVRAPFAFEGLFGHLAASAVPGVEEVRD
MSMEG_4925|M.smegmatis_MC2_155 HKARSRFG-PVSAAPGALTLRLPVRAPFAYEGLFGHLAASAAPGIEEVRG
TH_1537|M.thermoresistible__bu ARARSRRHGAPGL-PGTLSLRLPTRTPFAHDGVFGHLGAGTVPGIEEVRH
MAB_2333c|M.abscessus_ATCC_199 TELPRKECPAPEPIPGAVSLKLPLRQPHNIAWSTWLLEHHCARGVEDFSD
. : .* : *:*. * *. * . * *:.
Mb1350c|M.bovis_AF2122/97 GAYRRTLRLPWGNGIVSLTPAPDHVRCLLVLDDFRDLMTATARCRRLLDL
Rv1317c|M.tuberculosis_H37Rv GAYRRTLRLPWGNGIVSLTPAPDHVRCLLVLDDFRDLMTATARCRRLLDL
MMAR_4081|M.marinum_M GAYRRTLRLSSGNGIVTLTPAPDHVRCLLVLDDFRDLAAATARCRRLLDL
MUL_3945|M.ulcerans_Agy99 GAYRRTLRLSSGNGIVTLTPAPDHVRCLLVLDDFRDLAAATARCRRLLDL
MAV_1537|M.avium_104 GAYRRTLRLGFGTGIVTLTPAADHVRCELVLDDFRDLTAAIARCRRLLDL
Mflv_2326|M.gilvum_PYR-GCK GTYRRTLRLPHGKGIVSLTPHPDHVGCRLVLDDFRDLSTAIARCRRLLDL
Mvan_4322|M.vanbaalenii_PYR-1 GAYRRTLRLPRGNGIVSLTPHPDHVRCHLVVDDFRDLAAAIARCRRLLDL
MSMEG_4925|M.smegmatis_MC2_155 DTYRRTLRLPHGHGIVGLRPYPDHVRCELVLDDFRDLAAAIARCRRLLDL
TH_1537|M.thermoresistible__bu GAYRRTLRLPWGWGIVALTPQPDHVRCQLTLTDFRDLASAIARCRRLLDL
MAB_2333c|M.abscessus_ATCC_199 GRYTRALRMPHGPVIATLTVSADQVRADLQLTDMRDLAPAVARLRHLLDL
. * *:**: * *. * .*:* . * : *:*** .* ** *:****
Mb1350c|M.bovis_AF2122/97 DADPEAIVEALGADPDLRAVVGKAPGQRIPRTVDEAEFAVRAVLAQQVST
Rv1317c|M.tuberculosis_H37Rv DADPEAIVEALGADPDLRAVVGKAPGQRIPRTVDEAEFAVRAVLAQQVST
MMAR_4081|M.marinum_M DADPEAVVEALRGDPALGPVVATAPGQRIPRTVDEAELAVRAVLAQQVST
MUL_3945|M.ulcerans_Agy99 GADPEAVVEALSGDPALSPVVATAPGQRIPRTVDEAELAVRAVLAQQVST
MAV_1537|M.avium_104 DADPEAVDEAVAADPQLAPAVRKAPGQRIPRTVDEAELAVRAVLGQQVSI
Mflv_2326|M.gilvum_PYR-GCK DADPEAIVSALSADETLTALVAKAPGQRIPRTVDEHELAVRVVLGQQVSM
Mvan_4322|M.vanbaalenii_PYR-1 DADPEAVVDALSADDRLAALVAKAPGQRIPRCVDEHELALRVVLGQQVSM
MSMEG_4925|M.smegmatis_MC2_155 DADPEAVVEFLGADADLKAVVAKAPGQRIPRTVDEAELALRVVIGQQVSI
TH_1537|M.thermoresistible__bu DADPEAVIQHLRTDPHLSALVAKAPGQRIPRTVDGAELAIRVLLGQQVSV
MAB_2333c|M.abscessus_ATCC_199 DADPSAVDEALLSHRVLAPLVTEAPGIRVPGTVDGAELLLRTMIGQQISV
.***.*: . : . * . * *** *:* ** *: :*.::.**:*
Mb1350c|M.bovis_AF2122/97 KAASTHAGRLVAAYGRPVHDRHGALTHTFPSIEQLAEIDPGHLAVPKARQ
Rv1317c|M.tuberculosis_H37Rv KAASTHAGRLVAAYGRPVHDRHGALTHTFPSIEQLAEIDPGHLAVPKARQ
MMAR_4081|M.marinum_M KAARTHAARLVTAYGRPIHDQGGTLTHTFPSVQDLAEIDPIHLAVPKTRQ
MUL_3945|M.ulcerans_Agy99 KAARTHAARLVTAYGRPIHDQGGTLTHTFPSVQDLAEIDPIHLVVPKTRQ
MAV_1537|M.avium_104 RAARTHAGRLVAAYGRAVHDPEGTLTHTFPSVQQLADVDPIHLAVPKARQ
Mflv_2326|M.gilvum_PYR-GCK AAARTHAARLVQAYGQPVERAGGTLTHVFPSVTDLSEIDPENLAFPRARR
Mvan_4322|M.vanbaalenii_PYR-1 AAARTHAGRVAAAYGQSVDDPEGQLTHVFPSVAELSEIDPRHLAFPKARQ
MSMEG_4925|M.smegmatis_MC2_155 KAARTHVGRLVARYGSRIDDEGGGLTHVFPSVDQLAEMSPDDLAMPASRK
TH_1537|M.thermoresistible__bu KAARTHVRRLVTAYGEPIEDPGGDLTHLFPSVTGLADVLPEHLALPTARA
MAB_2333c|M.abscessus_ATCC_199 AAANTATASLVAALGEEVTDATGRVTHLFPTAETVAAAAQEVMAGPAARI
** * . :. * : * :** **: :: :. * :*
Mb1350c|M.bovis_AF2122/97 RTINALVASLADKSLVLDAGCDWQRARGQLLALPGVGPWTAEVIAMRGLG
Rv1317c|M.tuberculosis_H37Rv RTINALVASLADKSLVLDAGCDWQRARGQLLALPGVGPWTAEVIAMRGLG
MMAR_4081|M.marinum_M RTLSMMVDAIADRRVNLDAGCDWTRTREQLLDIPGVGPWTAEVIAMRGLG
MUL_3945|M.ulcerans_Agy99 RTLSMMVDAIADRRVNLDAGFDWTRAREQLLDIPGVGPWTAEVIAMRGLG
MAV_1537|M.avium_104 RTLAALVAGLADRSIVLDTGCDWQSARTQLLALPGVGPWTAEVIAMRGLG
Mflv_2326|M.gilvum_PYR-GCK RTLIALVGALADGSVTLDTGCDRDAARAALLGLPGIGPWTTEMIAMRGLG
Mvan_4322|M.vanbaalenii_PYR-1 RSLGALVTALAEGTVVLDPGCDWNAARERLLALPGIGPWSAEMIAMRGLG
MSMEG_4925|M.smegmatis_MC2_155 RTVLSMVRALADGTLVVDPGCDWGLAREQLLALPGVGPWTAEVIAMRGLG
TH_1537|M.thermoresistible__bu HSFSRLVQAIAAGDVELGPGADWERTRHRLLALPGVGPWTAEMIAMRGLG
MAB_2333c|M.abscessus_ATCC_199 AAIAGAADRLATGKLELHHGMTGTDLRRQLLDIKGIGPWTADYVVMRQLA
:. . :* : : * * ** : *:***::: :.** *.
Mb1350c|M.bovis_AF2122/97 DPDAFPASDLGLRLAAKKLGLPAQRRALTVHSARWRPWRSYATQHLWTTL
Rv1317c|M.tuberculosis_H37Rv DPDAFPASDLGLRLAAKKLGLPAQRRALTVHSARWRPWRSYATQHLWTTL
MMAR_4081|M.marinum_M DPDAFPVADLGVRLAAKQLGLPQRQPGLLERSARWRPWRSYATQHLWTTL
MUL_3945|M.ulcerans_Agy99 DPDAFPVADLGVRLAAKQLGLPQRQPDLLDRSARWRPWRSYATQHLWTTL
MAV_1537|M.avium_104 DPDAFPAADLGLRVAAKRLRLPSSQRSLTAASARWRPWRSYATQYLWTTL
Mflv_2326|M.gilvum_PYR-GCK DPDAFPRGDLGVIAAATQIGLPATPRGLAQHSVRWRPWRSYATQHLWTAL
Mvan_4322|M.vanbaalenii_PYR-1 DPDAFPVTDLGVITAAEQTGLPTAPRLLADHSDRWRPWRSYATQHLWTAL
MSMEG_4925|M.smegmatis_MC2_155 DPDAFPASDLGVRLAAEQLGLPADTRALTAYSCRWRPWRAYATQHLWTTL
TH_1537|M.thermoresistible__bu DPDAFPVDDLGLRRAAQQLGMRGSVRALTDHSIRWRPWRSYVTQHLWTAL
MAB_2333c|M.abscessus_ATCC_199 DPDVLLEHDLVLRRGATAAGVDMATARASS------PWRSYVSMHLWRKG
***.: ** : .* : ***:*.: :**
Mb1350c|M.bovis_AF2122/97 EHPVNQWPPQEKIA------
Rv1317c|M.tuberculosis_H37Rv EHPVNQWPPQEKIA------
MMAR_4081|M.marinum_M EHSVNDWPPRE-VA------
MUL_3945|M.ulcerans_Agy99 EHSVNDWPPRE-VA------
MAV_1537|M.avium_104 EHPVNHWPPQQPSKETA---
Mflv_2326|M.gilvum_PYR-GCK DHSVNEWPPKTTGGARCSTA
Mvan_4322|M.vanbaalenii_PYR-1 DHSVNQWPPREK--------
MSMEG_4925|M.smegmatis_MC2_155 EHDVNQWPVPLAT-------
TH_1537|M.thermoresistible__bu DHAVNEWPPAGPMKEAS---
MAB_2333c|M.abscessus_ATCC_199 IAALPRQLTRKPKGKS----
: