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MVFGGFGGVALGELQITFVSEPIVEPTEWYFDEPHHVVAVYQGGRILSKEIDFVDGLSRRYLPKVGDVLV VPMGSRAAITTQGERASFCRFDIPTRLLDQRDLQPRVAYSDPLILQLASRMYSVADRTDVIARLLRESLA DVVRLHLSDHYAALRPRPERRRLLDSAMQARVTEYIEDGLDADISLSALAGHAQMSTSEFRKAFTEVFGH TPYQFVLDRRMSRAKQLLATTDLSVTDISVAVGFSSPSHFATTFKTRIGVTPTAYRSGV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_1313 | - | - | 100% (269) | AraC family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_4794 | - | 4e-47 | 35.91% (259) | AraC family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_4709c | - | 3e-16 | 36.94% (111) | AraC family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1350c | alkAb | 5e-07 | 31.37% (102) | methylated-DNA--protein-cysteine methyltransferase |
| M. gilvum PYR-GCK | Mflv_2899 | - | 9e-13 | 36.36% (99) | helix-turn-helix domain-containing protein |
| M. tuberculosis H37Rv | Rv1317c | alkA | 5e-07 | 31.37% (102) | bifunctional methylated-DNA--protein-cysteine |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_1063 | - | 1e-08 | 29.59% (98) | transcriptional regulatory protein |
| M. avium 104 | MAV_4981 | - | 1e-05 | 30.21% (96) | transcriptional regulator, AraC family protein |
| M. smegmatis MC2 155 | MSMEG_6356 | - | 3e-42 | 43.00% (207) | AraC family transcriptional regulator |
| M. thermoresistible (build 8) | TH_3120 | - | 6e-13 | 32.19% (146) | PUTATIVE transcriptional regulator, AraC family with |
| M. ulcerans Agy99 | MUL_0821 | - | 7e-09 | 29.59% (98) | transcriptional regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_3996 | - | 2e-17 | 34.04% (141) | helix-turn-helix domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_1313|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_6356|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_1063|M.marinum_M --------------------------------------------------
MUL_0821|M.ulcerans_Agy99 --------------------------------------------------
Mb1350c|M.bovis_AF2122/97 --------------------------------------------------
Rv1317c|M.tuberculosis_H37Rv MHDDFERCYRAIQSKDARFDGWFVVAVLTTGVYCRPSCPVRPPFARNVRF
Mflv_2899|M.gilvum_PYR-GCK --------------------------------------------------
TH_3120|M.thermoresistible__bu --------------------------------------------------
MAV_4981|M.avium_104 --------------------------------------------------
Mvan_3996|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_1313|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_6356|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_1063|M.marinum_M --------------------------------------------------
MUL_0821|M.ulcerans_Agy99 --------------------------------------------------
Mb1350c|M.bovis_AF2122/97 ------------------------------MRSDVVARAMRLIADGTVDR
Rv1317c|M.tuberculosis_H37Rv LPTAAAAQGEGFRACKRCRPDASPGSPEWNVRSDVVARAMRLIADGTVDR
Mflv_2899|M.gilvum_PYR-GCK --------------------------------------------------
TH_3120|M.thermoresistible__bu --------------------------------------------------
MAV_4981|M.avium_104 --------------------------------------------------
Mvan_3996|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_1313|M.abscessus_ATCC_1997 ---------------------MVFGGFGGVALGELQITFVSEPIVEPTEW
MSMEG_6356|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_1063|M.marinum_M -----------------------------MAQAARLIQHRSGVPIYGYRT
MUL_0821|M.ulcerans_Agy99 -----------------------MDYLWRMAQAARLIQHRSGVPIYGYRT
Mb1350c|M.bovis_AF2122/97 DGVSGLAAQLGYTIRQLERLLQAVVGAGPLALARAQRMQTARVLIETTNL
Rv1317c|M.tuberculosis_H37Rv DGVSGLAAQLGYTIRQLERLLQAVVGAGPLALARAQRMQTARVLIETTNL
Mflv_2899|M.gilvum_PYR-GCK --------------------------------------------------
TH_3120|M.thermoresistible__bu -------------VAALVLDGLAIFEFGVICEVFGVDRTDDGVPPVDFTV
MAV_4981|M.avium_104 ---MADSSATPRVVVIVVFDDVTMLDVAGAGEVFAEANRFGADYLLKIAS
Mvan_3996|M.vanbaalenii_PYR-1 ------------------MDATGVDRRVPARLVLATRDGQLPGADLRVYQ
MAB_1313|M.abscessus_ATCC_1997 YFDEPHHVVAVYQGGRILSK----EIDFVDGLSRRYLPKVGDVLVVPMGS
MSMEG_6356|M.smegmatis_MC2_155 -----------------------------------MTPRDGNVWVIPAEL
MMAR_1063|M.marinum_M DPDIPRVSVLRPGPEDLGDR----ARHIHDFPALWYVPAAGLVYIAAAGQ
MUL_0821|M.ulcerans_Agy99 DPDIPRVSVRRPGPEDLGDR----ARHIHDFPALWYVPAAGLVYIAAAGQ
Mb1350c|M.bovis_AF2122/97 PFGDVAFAAGFSSIRQFNDT----VRLACDGTPTALRARAAARFESATAS
Rv1317c|M.tuberculosis_H37Rv PFGDVAFAAGFSSIRQFNDT----VRLACDGTPTALRARAAARFESATAS
Mflv_2899|M.gilvum_PYR-GCK -------------------------------------MRAKDLVDARYAE
TH_3120|M.thermoresistible__bu CGPRAGQPVRTSFGATLTPDSGLDGLAGADLVAIPAIRQDDYLPEALDAV
MAV_4981|M.avium_104 VDGRDVTTSIGTRLGVTDAVSSIESADTVLVAGSDNLPRRPIDPELVEAV
Mvan_3996|M.vanbaalenii_PYR-1 FHSHQTQVPPLRDIAVIGWQSRAQIALRCGAIRSRAQMSPGDFSILRPGY
MAB_1313|M.abscessus_ATCC_1997 RAAITTQGERASFCRFDIPTRLLDQRDLQPRVAY---SDPLILQLAS---
MSMEG_6356|M.smegmatis_MC2_155 SSAALVRNAAFEFAQLTLPAPSVGGATLRPVADR---QDPLLHNMVD---
MMAR_1063|M.marinum_M VLEPTQFGSLQGGVAMFFDPAALGGDGGSPWPSWR--THPLLFPFLHGHS
MUL_0821|M.ulcerans_Agy99 VLEPTQFGSLQAGVAMFFDPAALGGDGGSPWPSWR--THPLLFPFLHGHS
Mb1350c|M.bovis_AF2122/97 AGTVSLRLPVRAPFAFEGVFGHLAATAVPGCEEVR--DGAYRRTLRLPWG
Rv1317c|M.tuberculosis_H37Rv AGTVSLRLPVRAPFAFEGVFGHLAATAVPGCEEVR--DGAYRRTLRLPWG
Mflv_2899|M.gilvum_PYR-GCK PITVDDLAAAAGLSRAHFSRMFTRTFGESPRAYLQ--TRRLER-------
TH_3120|M.thermoresistible__bu RAAADAGAIILTVCSGAFLAGAAGLLDGRPCTTHWGLTEELARRYPTARV
MAV_4981|M.avium_104 KSVADRTRRLASICTGSFILGQAGLLDGRRATTHWHDVRLFARAFPEITV
Mvan_3996|M.vanbaalenii_PYR-1 ESTWQWSRGFQATVLYLNERRFADFASEVFDHHVDSVTIRESFQVQDSVI
MAB_1313|M.abscessus_ATCC_1997 ----RMYSVADRT---DVIA----------RLLRESLADVVRLHLSDHY-
MSMEG_6356|M.smegmatis_MC2_155 ----RIADLAARD---DVLS----------RLLRDSIAEGLRLHIRDRYG
MMAR_1063|M.marinum_M GGILRLEVPAARR---STWDGAIAAIEAELTARQQGYGQAVAAHLTLLLI
MUL_0821|M.ulcerans_Agy99 GGILRLEVPAARR---STWDGAIAAIEAELTTRQQGYGQAVTAHLTLLLI
Mb1350c|M.bovis_AF2122/97 NGIVSLTPAPDHVRCLLVLDDFRDLMTATARCRRLLDLDADPEAIVEALG
Rv1317c|M.tuberculosis_H37Rv NGIVSLTPAPDHVRCLLVLDDFRDLMTATARCRRLLDLDADPEAIVEALG
Mflv_2899|M.gilvum_PYR-GCK --------------------------------------------AASLLR
TH_3120|M.thermoresistible__bu DRNVLYVDDGDLITSAGTAAGIDACLHLVRRELGSEVTNTIARHMVVPPQ
MAV_4981|M.avium_104 EPDALFVCDGDVFTSAGISSGIDLALALVEMDYGTELVRAVARWLVVYLK
Mvan_3996|M.vanbaalenii_PYR-1 HHGLFLLATELRR----------------DEFGAALYRDALVTQLCVHLL
MAB_1313|M.abscessus_ATCC_1997 AALRPRPERRRLLDSAMQ----ARVTEYIEDGLDADISLSALAGHAQMST
MSMEG_6356|M.smegmatis_MC2_155 EAPSPDGKSVQMLDQGQQ----RRLVEFLHDSLDERIDLRTAANIVGMNV
MMAR_1063|M.marinum_M ELARLARDVVGDLRRSGEPL-LAEVFEVIDRRHAEPLSLRDVAAEVGMTP
MUL_0821|M.ulcerans_Agy99 ELARLARDVVGDLRRSGEPL-LAEVFEVIDRRHAEPLSLRDVAAEVGMTP
Mb1350c|M.bovis_AF2122/97 ADPDLRAVVGKAPGQRIPRT-VDEAEFAVRAVLAQQVSTKAASTHAGRLV
Rv1317c|M.tuberculosis_H37Rv ADPDLRAVVGKAPGQRIPRT-VDEAEFAVRAVLAQQVSTKAASTHAGRLV
Mflv_2899|M.gilvum_PYR-GCK HTDRSVADICVMVG--------LQSVGSFTTSFARAYGLPPAAYRASMPS
TH_3120|M.thermoresistible__bu RDGGQRQFIDQPIPVRHSEG-FAPHLDWILSNLDKTHTVASLARRANMSP
MAV_4981|M.avium_104 RAGGQSQFSALVEAEPPPRSPLRKVTAAISADPAADHSVKSLSARASLST
Mvan_3996|M.vanbaalenii_PYR-1 RHHAESRLRAHRHPGALNAAQAQQVTDYIEHNLDSDLCLSSLARVAGLSQ
. : .
MAB_1313|M.abscessus_ATCC_1997 SEFRKAFTEVFGHTPYQFVLDRRMSRAK----------------------
MSMEG_6356|M.smegmatis_MC2_155 RDFRPAFAQAFHTTLYQFVLDQRIKRAK----------------------
MMAR_1063|M.marinum_M GHLTTIVRRRTGRTVQEWIIERRMAQAR----------------------
MUL_0821|M.ulcerans_Agy99 GHLTTIVRRRTGRTVQEWIIERRMAQAR----------------------
Mb1350c|M.bovis_AF2122/97 AAYGRPVHDRHGALTHTFPSIEQLAEIDPGHLAVPKARQRTINALVASLA
Rv1317c|M.tuberculosis_H37Rv AAYGRPVHDRHGALTHTFPSIEQLAEIDPGHLAVPKARQRTINALVASLA
Mflv_2899|M.gilvum_PYR-GCK AAVHARIPSCILQRDTRPKADSRVKTAH----------------------
TH_3120|M.thermoresistible__bu RTFARRFVEETGRTPMQWVTDQRVLYAR----------------------
MAV_4981|M.avium_104 RQLTRLFQSELGTTPARYVEMVRIDAAR----------------------
Mvan_3996|M.vanbaalenii_PYR-1 YHFARLFKKRFGAPPHAYVQRRRIERAR----------------------
. ::
MAB_1313|M.abscessus_ATCC_1997 -----------------QLLATTDLS--VTDISVAVGFSSPSHFAT----
MSMEG_6356|M.smegmatis_MC2_155 -----------------ALLASTALT--MTEISFTVGFSSPSHFAT----
MMAR_1063|M.marinum_M -----------------ELLVATDLA--VGEVARRVGISDPGYFSR----
MUL_0821|M.ulcerans_Agy99 -----------------ELLVATDLA--VGEVARRVGISDPGYFSR----
Mb1350c|M.bovis_AF2122/97 DKSLVLDAGCDWQRARGQLLALPGVGPWTAEVIAMRGLGDPDAFPASDLG
Rv1317c|M.tuberculosis_H37Rv DKSLVLDAGCDWQRARGQLLALPGVGPWTAEVIAMRGLGDPDAFPASDLG
Mflv_2899|M.gilvum_PYR-GCK --------------------------------------------------
TH_3120|M.thermoresistible__bu -----------------RLLEETDLD--IHRIAARCGFGSTTLLRH----
MAV_4981|M.avium_104 --------------------AALDAGRSVAESARLAGFGSAETLRR----
Mvan_3996|M.vanbaalenii_PYR-1 -----------------HLVLHSDMP--LKEVVGVTGFCDQSHLTR----
MAB_1313|M.abscessus_ATCC_1997 --TFKTRIGVTPTA------------YRSGV-------------------
MSMEG_6356|M.smegmatis_MC2_155 --TFKQRVGVTPSA------------YRAHL-------------------
MMAR_1063|M.marinum_M --LFSRAHGTSPRQ------------WRALPPRH----------------
MUL_0821|M.ulcerans_Agy99 --LFSRAHGTSPRQ------------WRALPPRH----------------
Mb1350c|M.bovis_AF2122/97 LRLAAKKLGLPAQRRALTVHSARWRPWRSYATQHLWTTLEHPVNQWPPQE
Rv1317c|M.tuberculosis_H37Rv LRLAAKKLGLPAQRRALTVHSARWRPWRSYATQHLWTTLEHPVNQWPPQE
Mflv_2899|M.gilvum_PYR-GCK ----GEKTGANASP------------------------------------
TH_3120|M.thermoresistible__bu --HFRRVIGVTPSDYRRRFACGSTTSGSTESGAEVTD-------------
MAV_4981|M.avium_104 --VFVEHLGLSPKAYRDR--------FRTAARG-----------------
Mvan_3996|M.vanbaalenii_PYR-1 --AFRRAFDITPAELR-----------RSSD-------------------
. .
MAB_1313|M.abscessus_ATCC_1997 ---
MSMEG_6356|M.smegmatis_MC2_155 ---
MMAR_1063|M.marinum_M ---
MUL_0821|M.ulcerans_Agy99 ---
Mb1350c|M.bovis_AF2122/97 KIA
Rv1317c|M.tuberculosis_H37Rv KIA
Mflv_2899|M.gilvum_PYR-GCK ---
TH_3120|M.thermoresistible__bu ---
MAV_4981|M.avium_104 ---
Mvan_3996|M.vanbaalenii_PYR-1 ---