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MALCSTTAPVDLRSDGKRNRDRILEVARHHIAERRLELPMNVIAREAGVGVGTVYRHFPTRQSLLETVAA DGFGEITTISRRAAHEPDPAKSLRKLLGGSVKCLHRYPGLAPVLESQTFACSETVEMAASVGRSVEAVLK KARKAGLVRAGVSGDDLRWLILGVHHAASINIAGSGRHTRYLTIVMDGLRRPAVADR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3961 | - | - | 100% (197) | transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_0878 | - | 4e-18 | 32.79% (183) | transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_1380 | - | 6e-18 | 30.22% (182) | transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0068c | - | 5e-17 | 33.69% (187) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_0142 | - | 3e-15 | 32.78% (180) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv0067c | - | 5e-17 | 33.69% (187) | TetR family transcriptional regulator |
| M. leprae Br4923 | MLBr_00316 | - | 2e-13 | 30.98% (184) | putative TetR/AcrR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_0647 | - | 1e-19 | 34.97% (183) | transcriptional regulator TetR |
| M. marinum M | MMAR_2984 | - | 1e-06 | 27.21% (136) | TetR family transcriptional regulator |
| M. avium 104 | MAV_2463 | - | 2e-19 | 32.26% (186) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_2712 | - | 2e-07 | 48.39% (62) | PUTATIVE transcriptional regulator, TetR family |
| M. ulcerans Agy99 | MUL_3399 | - | 3e-06 | 44.44% (54) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_1492 | - | 1e-18 | 29.44% (180) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0068c|M.bovis_AF2122/97 -----------------------------MAPTDRRVRADAARNRARVLE
Rv0067c|M.tuberculosis_H37Rv -----------------------------MAPTDRRVRADAARNRARVLE
MLBr_00316|M.leprae_Br4923 ------------------MSVPRSGLSVQMAQPARPLRADAARNRARILG
MAB_0647|M.abscessus_ATCC_1997 -----------------------------MDQPARPLRADAARNRARVLE
Mflv_0142|M.gilvum_PYR-GCK --------------------------------MTRPLRADAARNRARVLE
MSMEG_3961|M.smegmatis_MC2_155 -------------------------MALCSTTAPVDLRSDGKRNRDRILE
Mvan_1492|M.vanbaalenii_PYR-1 -----------------------------MTPPDRPVRADAARNRALLLA
MAV_2463|M.avium_104 ----------------------------MTAVEDRPLRSDAARNVERILR
TH_2712|M.thermoresistible__bu ----VSLMSADELLPARPA--TDVAAP--TATTAPPEREDAARNRALLLD
MUL_3399|M.ulcerans_Agy99 MLQYLNGLWSDLFQPSYSAGVSGVEGLGELPVSARQERGDAARNRELLLQ
MMAR_2984|M.marinum_M ----------------------MTTSDRGAPAQANRSERRKRRTRTALLR
. *. :*
Mb0068c|M.bovis_AF2122/97 VAYQTFAADGLS-VPVDEIARRAGVGAGTVYRHFPTKEALFQAVIADRMH
Rv0067c|M.tuberculosis_H37Rv VAYQTFAADGLS-VPVDEIARRAGVGAGTVYRHFPTKEALFQAVIADRMH
MLBr_00316|M.leprae_Br4923 VAYEAFATEGLS-VPIDEIARRAGVGAGTVYRHFPTKEALCAAVIGDRMP
MAB_0647|M.abscessus_ATCC_1997 VAYQTFAEEGLG-VPIDEIARRAGVGAGTVYRHFPAKEDLYRAIAEDRMG
Mflv_0142|M.gilvum_PYR-GCK VAYDTFAAEGLT-VPIDEIARRAGVGAGTVYRHFPTKEALVVAVAEDRVR
MSMEG_3961|M.smegmatis_MC2_155 VARHHIAERRLE-LPMNVIAREAGVGVGTVYRHFPTRQSLLETVAADGFG
Mvan_1492|M.vanbaalenii_PYR-1 AAEEEFAERGPS-ASVADIARRAGVAKGTVFRHFPTKEDLIAAIVSEHIA
MAV_2463|M.avium_104 AAREVYAELGPD-APVEAVARRAGVGERTLYRRFPAKADLVRAALDQSIA
TH_2712|M.thermoresistible__bu AARRLIAERGAEAVTMDDIAAAAGVGKGTLFRRFGSRAGLMLELLHDDET
MUL_3399|M.ulcerans_Agy99 AARRLVAKRGAEAVTTDDIAAEAGVGKGTLFRRFGSRAGLMMVLLDEDER
MMAR_2984|M.marinum_M AAQRLIAEGKLN-VPVLEITQAADVGMGSFYNHFDSKEQLFEAAVADVLD
.* * . :: *.*. :.:.:* :: * :
Mb0068c|M.bovis_AF2122/97 RIIDKGHALLKSKHPGDALFAFLRSMVLQWGATDRGLVEALAGVG-IEIS
Rv0067c|M.tuberculosis_H37Rv RIIDKGHALLKSKHPGDALFAFLRSMVLQWGATDRGLVEALAGVG-IEIS
MLBr_00316|M.leprae_Br4923 HLVDDGYVLLKSAGPGEALFTYLRSLVLHWGATDRGLVDALAGAGGIDIL
MAB_0647|M.abscessus_ATCC_1997 SVIDKGRELLAAVDPGEALFEFLRSM-MDWGGTDQGLVDALSGAG-IDVQ
Mflv_0142|M.gilvum_PYR-GCK RIAERARTLLAVEGPGQALFVFFRDM-VRSAAVDHGLVDALMNQG-LDLE
MSMEG_3961|M.smegmatis_MC2_155 EITTISRRAAHEPDPAKSLRKLLGGS-VKCLHRYPGLAPVLESQT--FAC
Mvan_1492|M.vanbaalenii_PYR-1 VLAAAARRLADSPDPGAALLEFLTIAADQRQRHDLTFLQSASDGD-----
MAV_2463|M.avium_104 EDLTPVIDSARHAKDPLHGLTRLVEAAISLGAREQNLLAAAHRAG-----
TH_2712|M.thermoresistible__bu AFQQAFMFGPPPLGPGAEPLERLLAYGRRRLQFVCDHHALLTDVS-REPQ
MUL_3399|M.ulcerans_Agy99 ASQQAFLFGPPPLGPEAAPLDRLIAFGRERICFVHAHHELLSEAN-RNPL
MMAR_2984|M.marinum_M AHGALLDRCTASIEDPAETFAASFRLTGRLFRRRPQESEILLANG-----
Mb0068c|M.bovis_AF2122/97 SAAPEAEADFLDLLTDLLRAAQRAGTVRPDVDVLEVKTLLVG-CQAMQSY
Rv0067c|M.tuberculosis_H37Rv SAAPEAEADFLDLLTDLLRAAQRAGTVRPDVDVLEVKTLLVG-CQAMQSY
MLBr_00316|M.leprae_Br4923 GVAPDAEDAFLTILSDLLYAAQYAGTARTDVGVREVKSILVG-CQAMEAY
MAB_0647|M.abscessus_ATCC_1997 ALIPHIEESFYAVLGDLLRAAQQAGTVRSDVGVHEVKALLVG-CQAMQSY
Mflv_0142|M.gilvum_PYR-GCK AVAPGVEAAFLSTLGDLLSAAQGAGTVRPDVDVAVVKALLVV-CKVPQVF
MSMEG_3961|M.smegmatis_MC2_155 SETVEMAASVGRSVEAVLKKARKAGLVRAGVSGDDLRWLILG-VHHAASI
Mvan_1492|M.vanbaalenii_PYR-1 PRVTEVRDALHANLETLVDRARTSGAIRADITEADVFLMMCAPIHIVENL
MAV_2463|M.avium_104 SLTSDISVSLNEALGELVREGQRAGRIRADLVADDLPRLVAMLYSVLSTM
TH_2712|M.thermoresistible__bu TRFGPPMTLHHTHIRSLLAAADADG--DLDVQADALLALTDPDYVRHQVT
MUL_3399|M.ulcerans_Agy99 TRYGAAASVHRRHVRVLLESADTTG--DLDVQTDALLALLDVDYVEHQLN
MMAR_2984|M.marinum_M AALLSSDRGLAPRALRDIKAASDAGRFRVEDPELALAMAGGALLGLGTLL
: . * :
Mb0068c|M.bovis_AF2122/97 NA-----------ELAAKVT---DVALDGLRANRK---------------
Rv0067c|M.tuberculosis_H37Rv NA-----------ELAAKVT---DVALDGLRANRK---------------
MLBr_00316|M.leprae_Br4923 NS-----------ALAERVT---DVVVDGLRAAR----------------
MAB_0647|M.abscessus_ATCC_1997 NK-----------DVSRQVT---DVVFDGLRPRP----------------
Mflv_0142|M.gilvum_PYR-GCK DS-----------EVTERVT---RVIEDGLRPLR----------------
MSMEG_3961|M.smegmatis_MC2_155 NI-----------AGSGRHTRYLTIVMDGLRRPAVADR------------
Mvan_1492|M.vanbaalenii_PYR-1 PA-----------PAPLLWQRYLAIIFDGLRPDGAHPLPQPAPAAP----
MAV_2463|M.avium_104 DA-----------GSEGWRR-YVALVVDAISVDERRPLPPAAALRYASQP
TH_2712|M.thermoresistible__bu DR-----------GVALDALA--DSWGDVARKLCRR--------------
MUL_3399|M.ulcerans_Agy99 DR-----------GHTLRTLG--DAWEDLARKLCGR--------------
MMAR_2984|M.marinum_M RADPQRDGCAAADAVTEDLLRLFGLDAEQARAICRRPLPDLDGWDQPDSA
:
Mb0068c|M.bovis_AF2122/97 -----
Rv0067c|M.tuberculosis_H37Rv -----
MLBr_00316|M.leprae_Br4923 -----
MAB_0647|M.abscessus_ATCC_1997 -----
Mflv_0142|M.gilvum_PYR-GCK -----
MSMEG_3961|M.smegmatis_MC2_155 -----
Mvan_1492|M.vanbaalenii_PYR-1 -----
MAV_2463|M.avium_104 NSWPL
TH_2712|M.thermoresistible__bu -----
MUL_3399|M.ulcerans_Agy99 -----
MMAR_2984|M.marinum_M A----