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SAPETPERPLRKDAERNRKRVLEAARELFAAKGLEPNLNDVARHAGVGVGTVYRRFATKEELLEAIFEDA MNQLTDLAEEALRKSDSWQGFAWFVEQQCQLTVTDRGLREIAFSKCYGGDRVKAAQDRLSVVTTELVERA QRDGHLRPGVSATDLPLLALLAGTVTEFAGHVDADLWRRYTSILLEGMRHHPGQEPVAVFALDRPALEAA MRTWEPAGPPSHRPRPPCPPCAT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1380 | - | - | 100% (234) | transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_3807 | - | 1e-22 | 35.05% (194) | TetR-type regulator |
| M. smegmatis MC2 155 | MSMEG_0878 | - | 9e-21 | 35.98% (189) | transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0068c | - | 3e-22 | 35.14% (185) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_0142 | - | 3e-21 | 33.33% (183) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv0067c | - | 3e-22 | 35.14% (185) | TetR family transcriptional regulator |
| M. leprae Br4923 | MLBr_00316 | - | 1e-19 | 34.57% (188) | putative TetR/AcrR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_4384 | - | 1e-76 | 62.56% (219) | TetR family transcriptional regulator |
| M. marinum M | MMAR_1637 | - | 4e-08 | 42.86% (63) | TetR family transcriptional regulator |
| M. avium 104 | MAV_2463 | - | 6e-20 | 33.15% (184) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_2712 | - | 2e-09 | 44.44% (72) | PUTATIVE transcriptional regulator, TetR family |
| M. ulcerans Agy99 | MUL_3399 | - | 3e-08 | 42.86% (63) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_1059 | - | 8e-78 | 64.19% (215) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0068c|M.bovis_AF2122/97 -----------------------------MAPTDRRVRADAARNRARVLE
Rv0067c|M.tuberculosis_H37Rv -----------------------------MAPTDRRVRADAARNRARVLE
MLBr_00316|M.leprae_Br4923 ------------------MSVPRSGLSVQMAQPARPLRADAARNRARILG
Mflv_0142|M.gilvum_PYR-GCK --------------------------------MTRPLRADAARNRARVLE
MSMEG_1380|M.smegmatis_MC2_155 --------------------------MSAPETPERPLRKDAERNRKRVLE
Mvan_1059|M.vanbaalenii_PYR-1 ----------------------------MIDKPCRGLRKDAERNRQRVLT
MAB_4384|M.abscessus_ATCC_1997 --------------------------MNGREVAHRPLRKDAERNRKRVIA
MMAR_1637|M.marinum_M --------------------MSGVEGLGELPVSARQERGDAARNRELLLQ
MUL_3399|M.ulcerans_Agy99 MLQYLNGLWSDLFQPSYSAGVSGVEGLGELPVSARQERGDAARNRELLLQ
TH_2712|M.thermoresistible__bu ----VSLMSADELLP----ARPATDVAAPTATTAPPEREDAARNRALLLD
MAV_2463|M.avium_104 ----------------------------MTAVEDRPLRSDAARNVERILR
* ** ** ::
Mb0068c|M.bovis_AF2122/97 VAYQTFAADGLSVP-VDEIARRAGVGAGTVYRHFPTKEALFQAVIADRMH
Rv0067c|M.tuberculosis_H37Rv VAYQTFAADGLSVP-VDEIARRAGVGAGTVYRHFPTKEALFQAVIADRMH
MLBr_00316|M.leprae_Br4923 VAYEAFATEGLSVP-IDEIARRAGVGAGTVYRHFPTKEALCAAVIGDRMP
Mflv_0142|M.gilvum_PYR-GCK VAYDTFAAEGLTVP-IDEIARRAGVGAGTVYRHFPTKEALVVAVAEDRVR
MSMEG_1380|M.smegmatis_MC2_155 AARELFAAKGLEPN-LNDVARHAGVGVGTVYRRFATKEELLEAIFEDAMN
Mvan_1059|M.vanbaalenii_PYR-1 AARELFAVEGMEAS-LNDVARHAGVGVGTVYRRFATKEELVEAIFESGVD
MAB_4384|M.abscessus_ATCC_1997 AARELFAVHGLEST-LNEVAHHAGLGVGTVYRRFPTKEALFEAIYVDGMD
MMAR_1637|M.marinum_M AARRLVAKRGAEAVTTDDIAAEAGVGKGTLFRRFGSRAGLMMVLLDEDER
MUL_3399|M.ulcerans_Agy99 AARRLVAKRGAEAVTTDDIAAEAGVGKGTLFRRFGSRAGLMMVLLDEDER
TH_2712|M.thermoresistible__bu AARRLIAERGAEAVTMDDIAAAAGVGKGTLFRRFGSRAGLMLELLHDDET
MAV_2463|M.avium_104 AAREVYAELGPDAP-VEAVARRAGVGERTLYRRFPAKADLVRAALDQSIA
.* * * : :* **:* *::*:* :: * .
Mb0068c|M.bovis_AF2122/97 RIIDKGHALLKSKHPGDALFAFLRSMVLQWGATDRGLVEALAGVG-IEIS
Rv0067c|M.tuberculosis_H37Rv RIIDKGHALLKSKHPGDALFAFLRSMVLQWGATDRGLVEALAGVG-IEIS
MLBr_00316|M.leprae_Br4923 HLVDDGYVLLKSAGPGEALFTYLRSLVLHWGATDRGLVDALAGAGGIDIL
Mflv_0142|M.gilvum_PYR-GCK RIAERARTLLAVEGPGQALFVFFRDMVRS-AAVDHGLVDALMNQG-LDLE
MSMEG_1380|M.smegmatis_MC2_155 QLTDLAEEALRKSDSWQG-FAWFVEQQCQLTVTDRGLREIAFSKC--YGG
Mvan_1059|M.vanbaalenii_PYR-1 EVVCLAEAALRHQDSWEG-FVWFVERQCLLTATDRGLREMVYSKA--YGG
MAB_4384|M.abscessus_ATCC_1997 QLSGLAEAALRHENSWEG-FEWFVHQMCEITATNRGLREIAFSKA--HGG
MMAR_1637|M.marinum_M ASQQAFLFGPPPLGPEAAPLDRLIAFGRERICFVHAHHELLSEAN-RNPL
MUL_3399|M.ulcerans_Agy99 ASQQAFLFGPPPLGPEAAPLDRLIAFGRERICFVHAHHELLSEAN-RNPL
TH_2712|M.thermoresistible__bu AFQQAFMFGPPPLGPGAEPLERLLAYGRRRLQFVCDHHALLTDVS-REPQ
MAV_2463|M.avium_104 EDLTPVIDSARHAKDPLHGLTRLVEAAISLGAREQNLLAAAHRAG-----
: :
Mb0068c|M.bovis_AF2122/97 SAAPEAEADFLDLLTDLLRAAQRAGTVRPDVDVLEVKTLLVGCQAMQSYN
Rv0067c|M.tuberculosis_H37Rv SAAPEAEADFLDLLTDLLRAAQRAGTVRPDVDVLEVKTLLVGCQAMQSYN
MLBr_00316|M.leprae_Br4923 GVAPDAEDAFLTILSDLLYAAQYAGTARTDVGVREVKSILVGCQAMEAYN
Mflv_0142|M.gilvum_PYR-GCK AVAPGVEAAFLSTLGDLLSAAQGAGTVRPDVDVAVVKALLVVCKVPQVFD
MSMEG_1380|M.smegmatis_MC2_155 DRVKAAQDRLSVVTTELVERAQRDGHLRPGVSATDLPLLALLAGTVTEFA
Mvan_1059|M.vanbaalenii_PYR-1 NRVERVRERLAPLMKELVERARRDGYLRPDVESTDMPVIGLLAGTVGEWA
MAB_4384|M.abscessus_ATCC_1997 DHVEAGRARLLPLLSKVVERAQEDGYLRPEASATDMPFFGVLTGAVSEFA
MMAR_1637|M.marinum_M TRYGAAASVHRRHVRVLLESADTTG----DLDVQTDALLALLDVDYVEHQ
MUL_3399|M.ulcerans_Agy99 TRYGAAASVHRRHVRVLLESADTTG----DLDVQTDALLALLDVDYVEHQ
TH_2712|M.thermoresistible__bu TRFGPPMTLHHTHIRSLLAAADADG----DLDVQADALLALTDPDYVRHQ
MAV_2463|M.avium_104 SLTSDISVSLNEALGELVREGQRAGRIRADLVADDLPRLVAMLYSVLSTM
:: . * :
Mb0068c|M.bovis_AF2122/97 ----AELAAKVTDVALDGLRANRK--------------------------
Rv0067c|M.tuberculosis_H37Rv ----AELAAKVTDVALDGLRANRK--------------------------
MLBr_00316|M.leprae_Br4923 ----SALAERVTDVVVDGLRAAR---------------------------
Mflv_0142|M.gilvum_PYR-GCK ----SEVTERVTRVIEDGLRPLR---------------------------
MSMEG_1380|M.smegmatis_MC2_155 GHVDADLWRRYTSILLEGMRHHPGQEPVAVFALDRPALEAAMRTWEPAGP
Mvan_1059|M.vanbaalenii_PYR-1 GDVDPELWRRYVELLLEGMRCRPDQKPLDVDALGEEQMHAAMHGWDPSG-
MAB_4384|M.abscessus_ATCC_1997 GEVNADLWRRYMAILIEGMRRRDDQERLEVDALDEAQIDAAMTTWQPAGS
MMAR_1637|M.marinum_M LNDRGHTLRTLGDAWEDLARKLCGR-------------------------
MUL_3399|M.ulcerans_Agy99 LNDRGHTLRTLGDAWEDLARKLCGR-------------------------
TH_2712|M.thermoresistible__bu VTDRGVALDALADSWGDVARKLCRR-------------------------
MAV_2463|M.avium_104 DAG-SEGWRRYVALVVDAISVDERRPLPPAAALRYASQPNSWPL------
:
Mb0068c|M.bovis_AF2122/97 --------------
Rv0067c|M.tuberculosis_H37Rv --------------
MLBr_00316|M.leprae_Br4923 --------------
Mflv_0142|M.gilvum_PYR-GCK --------------
MSMEG_1380|M.smegmatis_MC2_155 PSHRPRPPCPPCAT
Mvan_1059|M.vanbaalenii_PYR-1 --------------
MAB_4384|M.abscessus_ATCC_1997 G-------------
MMAR_1637|M.marinum_M --------------
MUL_3399|M.ulcerans_Agy99 --------------
TH_2712|M.thermoresistible__bu --------------
MAV_2463|M.avium_104 --------------