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SSEPSISDGARKIDAELGSVDVLVNNAAVALLAPATEYTTTDWDTTMATNLRGVFLCTREFGRGMVDRGW GRVVNIASQNAIQGIGGHVAYSAAKAGILGMSRVLAAEWGPHGVTVNCASPTLVDTPMSRATWPDAARAQ VIERIPTRRLATFDDVTSTVLYLAGEGAGMVNGHNFVVDGGASVAF*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3912 | - | - | 100% (187) | acetoacetyl-CoA reductase |
| M. smegmatis MC2 155 | MSMEG_3607 | - | 3e-41 | 44.09% (186) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4117 | - | 1e-34 | 39.68% (189) | 2-deoxy-D-gluconate 3-dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1976 | - | 3e-25 | 35.94% (192) | short-chain type dehydrogenase/reductase |
| M. gilvum PYR-GCK | Mflv_2469 | - | 9e-27 | 33.86% (189) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv1941 | - | 3e-25 | 35.94% (192) | short-chain type dehydrogenase/reductase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 1e-22 | 29.67% (182) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_0296 | - | 4e-24 | 31.09% (193) | putative 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase |
| M. marinum M | MMAR_4715 | - | 7e-25 | 33.51% (185) | 3-oxoacyl- |
| M. avium 104 | MAV_1395 | - | 5e-29 | 36.56% (186) | 2-hydroxycyclohexanecarboxyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_3102 | - | 4e-29 | 37.71% (175) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_0315 | fabG2 | 5e-25 | 33.51% (185) | 3-oxoacyl- |
| M. vanbaalenii PYR-1 | Mvan_4185 | - | 4e-28 | 34.92% (189) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2469|M.gilvum_PYR-GCK ------------------MSSRVAVVTGGASGMGESTCHELGRRGHKVAV
Mvan_4185|M.vanbaalenii_PYR-1 -------------------MTRVAVVTGGASGMGEATCHELGRRGCKVAV
MAV_1395|M.avium_104 ----------------------MAVVTGGGSGIGRAIVERLAHDGHRVAV
MMAR_4715|M.marinum_M ----------MK----------TAVVTGGASGIGLAIARRLRADGIDVAT
MUL_0315|M.ulcerans_Agy99 ----------MRPDSSPSWCTITSVVTGGASGIGLAIARRLSADGTDVAT
TH_3102|M.thermoresistible__bu ----------LK----------NAVVTGGGSGIGQAVAARLRADGYHVAT
MLBr_01807|M.leprae_Br4923 MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLAVARRLVADGHRVAV
MAB_0296|M.abscessus_ATCC_1997 ---------------------MVAVVTGAGGGVGSRVVTTLARRHERVVA
Mb1976|M.bovis_AF2122/97 -------------MNHPDLAGKVAIVTGAGAGIGLAVARRLADEGCHVLC
Rv1941|M.tuberculosis_H37Rv -------------MNHPDLAGKVAIVTGAGAGIGLAVARRLADEGCHVLC
MSMEG_3912|M.smegmatis_MC2_155 ------------------MSSEPSISDGARK-------------------
: *.
Mflv_2469|M.gilvum_PYR-GCK LDLNGEAAQRVAEELRADGVTALGIAADVTDRAAVEDAFAKVRTELGPVH
Mvan_4185|M.vanbaalenii_PYR-1 LDLDGQAAQRVAEELRGDGVPALGVAADVTDRAAVEDAFAKVRTELGPVH
MAV_1395|M.avium_104 LDVNEEAAEKVAARVAADGAHAIAVPTDVAESASVAAAFESVRRALGSVQ
MMAR_4715|M.marinum_M LDLKTPDGE-------------LAFSADVTNRSQVDAALTAIRQRLGPVT
MUL_0315|M.ulcerans_Agy99 LDLKTPDGG-------------LAFSADVTNRSQVDAALAAIRQRLGPVT
TH_3102|M.thermoresistible__bu IDLKPGDDE-------------FSHAADVTDRAQVDAAFDAIRTQLGPVT
MLBr_01807|M.leprae_Br4923 THRASVVPD-----------WFFGVECDVTDNDAIGAAFKAVEEHQGPVE
MAB_0296|M.abscessus_ATCC_1997 VDIDEVAIKQLVEYAADEGLDVIGQILDITDDTAVAVGVSDIESRVGPIT
Mb1976|M.bovis_AF2122/97 ADIDGDAADAAATKI---GCGAAACRVDVSDEQQIIAMVDACVAAFGGVD
Rv1941|M.tuberculosis_H37Rv ADIDGDAADAAATKI---GCGAAACRVDVSDEQQIIAMVDACVAAFGGVD
MSMEG_3912|M.smegmatis_MC2_155 --ID---------------------------------------AELGSVD
* :
Mflv_2469|M.gilvum_PYR-GCK ILVTSAGLVDFAPFLDISPQLWQRLIDVNLNGTFHCAQAAIPDMLAAGWG
Mvan_4185|M.vanbaalenii_PYR-1 ILVTSAGLVDFAPFLEISPDRWQRLIEVNLNGTFHCAQVAIPDMLAAGWG
MAV_1395|M.avium_104 VLVTSAAITGFKPFAEITIEDWNRHLAVNLTGTFLCLQAALPDMVEAGWG
MMAR_4715|M.marinum_M ILVNAAGLDGFKRFSNITFEDWQRVIDVNLNGVFHTIQAVLPDMVAAGWG
MUL_0315|M.ulcerans_Agy99 ILVNAAGLDGFKRFSNITFEDWQRVIDVNLNGVFHTIQAVLPDMVAAGWG
TH_3102|M.thermoresistible__bu ILVNAAGLDLFRRFTDISFEDWERVINVNLHGVFHCIQAVLPDMIEAGWG
MLBr_01807|M.leprae_Br4923 VLVANAGITSDMLIMRMSEEQFQKVIDVNLTGVFRVAKLASRNMIKQRFG
MAB_0296|M.abscessus_ATCC_1997 ALVNGAGVLRTGAAVEFSDADWARTFDVNVRAPFVLSREVARRMIPRRAG
Mb1976|M.bovis_AF2122/97 KLVANAGVVHLASLIDTTVEDFDRVIAINLRGAWLCTKHAAPRMIERGGG
Rv1941|M.tuberculosis_H37Rv KLVANAGVVHLASLIDTTVEDFDRVIAINLRGAWLCTKHAAPRMIERGGG
MSMEG_3912|M.smegmatis_MC2_155 VLVNNAAVALLAPATEYTTTDWDTTMATNLRGVFLCTREFGRGMVDRGWG
** *.: : : : *: . : : *: *
Mflv_2469|M.gilvum_PYR-GCK RIVMISSSSAQRGSPGMAHYAASKGALISLTRSLAREYGAAGITVNNIPP
Mvan_4185|M.vanbaalenii_PYR-1 RIVMISSSSAQRGSPGMAHYAASKGALISFTRSLAREYGPAGITVNNVPP
MAV_1395|M.avium_104 RVVTISSTAAQTGSPRQGHYSASKGGVIALTRTIALEYAAHGITANTVPP
MMAR_4715|M.marinum_M RIVNISSSSTHSGTPYMTHYVAAKSAVNGLTKALALEYGPSGITVNAVPP
MUL_0315|M.ulcerans_Agy99 RIVNISSSSTHSGTPYMTHYVAAKSAVNGLTKALALEYGPSGITVNAVPP
TH_3102|M.thermoresistible__bu RIVNISSSSTHSGAPYMAPYVAAKSGVNGLTKTLALEYGPAGITVNAVPP
MLBr_01807|M.leprae_Br4923 RYIFMGSVVGLSGVPGQANYAASKSGLIGMARSLARELGSRSITANVVAP
MAB_0296|M.abscessus_ATCC_1997 SVVTVASNAALVARKGMTAYAASKAAANAFTKSLGLELAEYGIRCNVVAP
Mb1976|M.bovis_AF2122/97 AIVNLSSLAGQVAVGGTGAYGMSKAGIIQLSRITAAELRSSGIRSNTLLP
Rv1941|M.tuberculosis_H37Rv AIVNLSSLAGQVAVGGTGAYGMSKAGIIQLSRITAAELRSSGIRSNTLLP
MSMEG_3912|M.smegmatis_MC2_155 RVVNIASQNAIQGIGGHVAYSAAKAGILGMSRVLAAEWGPHGVTVNCASP
: :.* . * :*.. ::: . * .: * *
Mflv_2469|M.gilvum_PYR-GCK SGIETPMQLQSQAAGF-----LPPNEQMAASIPVGHLGTGDDIAAAVGFL
Mvan_4185|M.vanbaalenii_PYR-1 SGIETPMQHQSQAAGF-----LPPNEQMAASIPVGHLGTGDDIAAAVGFL
MAV_1395|M.avium_104 FSVDTPMLRAAQEAGN-----LPPVKYLAKASPVGRLGTGEDIAAACAFL
MMAR_4715|M.marinum_M GFIDTPMLRNAAAQGH-----LGDIEQNIARTPVRRIGKPEDIAAACAFL
MUL_0315|M.ulcerans_Agy99 GFIDTPMLRNAAAQGH-----LGDIEQNIARTPVRRIGKPEDIAAACAFL
TH_3102|M.thermoresistible__bu GFIDTPMLRAAAAKGY-----LGDIDKTIEATPVRRMGKPEDIAAACAFL
MLBr_01807|M.leprae_Br4923 GFIDTEMTRAMDSK---------YQEAALQAIPLGRIGAVEEIAGAVSFL
MAB_0296|M.abscessus_ATCC_1997 GSTDTPMLRAMLGDSSDAGLVAGSLGDYKPGIPLGRVAQPQHIADAVAFL
Mb1976|M.bovis_AF2122/97 AFVDTPMQQTAMAMFDG-ALGAGGARSMIARLQG-RMAAPEEMAGIVVFL
Rv1941|M.tuberculosis_H37Rv AFVDTPMQQTAMAMFDG-ALGAGGARSMIARLQG-RMAAPEEMAGIVVFL
MSMEG_3912|M.smegmatis_MC2_155 TLVDTPMSR---ATWPD-AARA----QVIERIPTRRLATFDDVTSTVLYL
:* * ::. :.:: :*
Mflv_2469|M.gilvum_PYR-GCK CSEQAGFITGQTLGVNGGSVMA--
Mvan_4185|M.vanbaalenii_PYR-1 CSEEAGFITGQTLGVNGGSVMA--
MAV_1395|M.avium_104 CSDEAGYITGQIIGVNGGEVI---
MMAR_4715|M.marinum_M VSEEAGYITGQILGVNGGRNT---
MUL_0315|M.ulcerans_Agy99 VSEEAGYITGQILGVNGGRNT---
TH_3102|M.thermoresistible__bu ISEEAGYITGQILGVNGGRNT---
MLBr_01807|M.leprae_Br4923 ASEDAGYISGAVIPVDGGLGMGH-
MAB_0296|M.abscessus_ATCC_1997 LSDQAAHITMHTLVVDGGATLGV-
Mb1976|M.bovis_AF2122/97 LSDDASMITGTTQIADGGTIAALW
Rv1941|M.tuberculosis_H37Rv LSDDASMITGTTQIADGGTIAALW
MSMEG_3912|M.smegmatis_MC2_155 AGEGAGMVNGHNFVVDGGASVAF-
.: *. :. .:**