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MVGDPTRRLLSIDLLDDDEHDRLDDWGNRSALTRPAAQQKTIPQLFSAQVTRTPTAHALVCGERVFTYRE LDEATDRLAMRLTRSGSGPGQCVALLLPRSAEAIIAILAVLKSGAAYLPMDTAHPDARLRFMLHDAKPVA AVTTSALHTRLTGTGIPLLDIDACDTGASAPIRPPVPDDLAYLTYTSGTTGVPKAVAVTHRNVTQLLECP HPELPASPGQVWSQWHSLVFDVSVWEICGALLHGNRLVVVPESIASSPHELNALLVRERVTVLCQTPSSA GMLSAEGLDRTALVVAGEACPADLVQRWAPGRVMLNAYGPTEATVYAAMSSPLSSDADPVPIGRPVPHAA AFVLDKFLRPVLDGVIGELYIAGAGVAVGYARRSALTASRFVACPFGTPGQRMYRTGDLVRWDDDGHLVY LGRCDEQVKIHGYRIELGEVQAALAGLDGVDQAVVTVREDRPGDQRLVGYIIGAADPSASRRALAERLPA YMVPAAVVVLDSLPLTVNGKLDKRALPAPDYRGDAGSFRAPTSDVERILTDIYSEVLGVDRVGVDDSFFA LGGDSILSMRVVAQARMQGLRLRPRDVFVEQTVARLAATATLVSGQREPGEDVTAPVTATPMMRWLQTVD GQVDQFHQAMVLQAPADAAGCEFADVVDVLQDLLDHHAALRLCASGDGPSAPVLEVGAVRAADCVQSVDT LCAETLAKARSRLNPAEGRLLSALWVPHTHQLVLMIHHIGVDGVSWRILLEDLNIAWAQRRAHQRVELPA EGTSLAHWSALLQKHAYSPEVVAQAGAWQKVLSIATPLPETQPAVDTYATAGHLSVSLDSETTRQLLGDV PAAFHAGVGDIMLIAYALAWNEFRGGGSASITIDVEGHGRDEELGDVFGEDIDLSRTVGWFTTKYPVAIT VAPLRWDLVRDGAPALGAMIKSAKEQLHSLPGTSTYGLLRHLNTDVDLSGPEPTIGFNYLGRVGADHLGD RLWRIDPDGLALAEVASAVPMPLMHTLELNAGTLQVDSPAGTPEPALQAAWTWAPSAVDEAQVKRLSQLW FEALTGICAHVRSGGGGWTPSDIAPAVLTQSQIDQIAEQYRVADILPLTPLQQGLFFHSLIGPGEASTDV YAVQLDITVTGLLDADRLHDALLTVLRRHPNLVARFCGDFDPPVQIIPDDPVMAWRYMDLREDDRPPEVE IEKLCTAERVAVCHLTDRPAFRAALIRTAGNQHRFVMTFHHIVVDGWSLPILLKEIFGAYFEHRLPAPRP YRDFVGWLSAQDHDAARAAWHEVMGGFASPTVLTHPGPPGPRRAHTYHVPAETTRAVGDLARSCRTTVNT VLQAAWAQLLMALTGQHDVAFGTAVSGRPAELAGSDSLVGLLINTIPVRANVPPTASVSDLLDQLQRTHN ATVDHEYMSLNEIHRITGHDQLFDTLFVYESYPFDAGAFAGTHELAITDFTTREHNHYPLSVIAIPGHEL GLRAEFDSVRFTDDDIEELIERFLRVLAAMIDDPERRVSTIDVLGTSERERLDSWCRRERLRGKGSGSSS IPERFSAQVVRTPDSVAVTCGGESLTYAELDETADRLANLLTLHGAGPGTYVAIMLPRCAQAIVAILAVL KTGAAYLPIDPVLPDARVQFMLDDTAPIAAVTNDELRSRFDGFAGVVVEADDPAMSLHPTTALLAPAADD IAYVIYTSGTTGRPKGVAVTHHNVTRLFDAPYPGLTFGSGQVWTQCHSTGFDFSVWEIWSALLHGGRLVV VPESVTSSPSDLHELLVTEHVTMFSQTPAAAAALSHTGLEDLTLVVGGEACPSEVVQRWAPKRTMINGYG PTETTVFASTSEPLNPSSPGDVPIGAPVPGAAVFVLDSWLRPVPPGVAGEVYVAGGGVTVGYVHRPGMTA SRFVACPFAADGSRMYRTGDLARWGTDGQLRYLGRADDQVKIRGFRIELGEIQCALADLDGVDQAAVVVR EDQPGDKRLVGYITGTMDPAVAREMLADHLPPYMVPAAVLRLDTLPVTVNGKLDQRALPVPGYGNTRIHR PPVTRTEKVVAGVFGQVLGVEQVGIDDSFFDLGGDSISAMRCVAAINTALDVGVGVQDLLQAPQVRLLSR QIEGVGETDTLAAGGATVESVHGSADVTEIRAADLTLDKFIDDAALSAARNLPRTDAKIRTVLLTGATGF LGRFLVLEWLQRLEPVDGKLVCLVRAASDAEARVRLEKVFDCGDPLLLNRFRQLSTNRLQVVAGDKSAAA LGLDQETWTELAASVDLVIDSAGFVNGILPYREFFGPNVAGTAEVIRFALTTKLKSYAYVSTADVRQQID PAAFTEDADIRVISPSRQMDAGYASGYGNSKWAGEVLLREAHDLCGLPVRVFRCDMILTDTTYSGQLNLP DNFTRMVLSVVSTGLAPASFYQLDNTGERQRAHYDALPVGFVAEAISTLSVGAVDGFETYHVMNPHDDGV GADQYVDWLIEAGYPIRRIADFAEWLRRFETALRSLPERQRQHSVLQILTARHDLAQGADLQAPEPTLGS YGPTDRFRAAVREHRIGGEGDIPHVTPQIIIKYVADLQRLGLLDAHPTSAPRSA
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. smegmatis MC2 155 | MSMEG_3715 | - | - | 100% (2574) | linear gramicidin synthetase subunit C |
M. smegmatis MC2 155 | MSMEG_0402 | - | 0.0 | 63.84% (2583) | linear gramicidin synthetase subunit D |
M. smegmatis MC2 155 | MSMEG_0400 | - | 0.0 | 57.35% (1993) | peptide synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0104 | nrp | 0.0 | 50.69% (1517) | peptide synthetase |
M. gilvum PYR-GCK | Mflv_2697 | - | 1e-155 | 36.00% (1061) | amino acid adenylation domain-containing protein |
M. tuberculosis H37Rv | Rv0101 | nrp | 0.0 | 50.69% (1517) | peptide synthetase |
M. leprae Br4923 | MLBr_00484 | fadD9 | 1e-168 | 37.87% (1125) | putative acyl-CoA synthetase |
M. abscessus ATCC 19977 | MAB_4098c | - | 0.0 | 63.35% (2595) | peptide synthetase NRP |
M. marinum M | MMAR_0099 | - | 0.0 | 56.07% (2142) | non-ribosomal peptide synthetase |
M. avium 104 | MAV_3243 | - | 0.0 | 63.51% (2573) | linear gramicidin synthetase subunit B |
M. thermoresistible (build 8) | TH_3730 | - | 0.0 | 61.82% (1967) | PUTATIVE linear gramicidin synthetase subunit D |
M. ulcerans Agy99 | MUL_1722 | - | 1e-173 | 39.04% (1099) | fatty-acid-CoA ligase FadD9 |
M. vanbaalenii PYR-1 | Mvan_2578 | - | 1e-176 | 39.48% (1112) | thioester reductase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- MSMEG_3715|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK --MTAAKTGAIADVMALSPLQQGLYSLTAMS--DGDDPYLIGMSADITGA MMAR_0099|M.marinum_M MTQPTKPVVDIEDVMTLSPLQLGLFALAMASGAASDDPYTVALGIDVHGS Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- MSMEG_3715|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK LDVSLLHDCAAAVLARHPNLRAGFFQGDLKRPVQVIPEKVEVLWRHVRCD MMAR_0099|M.marinum_M LDVGLLRSCALAMLKRHPNLRARFLGRGLPHPVQVVPSEVQLEWARVEAT Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- MSMEG_3715|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK GTEVEPLEREERARRFDLGRGPAMRFLLLETGQQRWRFVITAHHIVIDGW MMAR_0099|M.marinum_M AETAGALEAQERNRGFDLEMGPAIRFLLIELPGDRWRFLITAHHIVIGGW Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- MSMEG_3715|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK SLSLLVSELLALYRAAGNTSALPDAPRPYRDYIGWLAARDQDHARSLWRA MMAR_0099|M.marinum_M SIALFVDELLTLYEADCNIDTLPAQPRPYRDYIGWLERCDVEQGQRQWRE Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- MSMEG_3715|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK HLADLDGPTLLAPALGAATIG-DGLPGMVELTADPSITEAVVDAARARGV MMAR_0099|M.marinum_M HLAGLAAPTLLAAPLGSSGVQPDSLPKRAELTLDEGATTSLVDGARSRGV Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- MSMEG_3715|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK TVNSLVQLAWALTLSSLTDRDDITFGVTVSGRPDDLAGVESMIGLFVNTV MMAR_0099|M.marinum_M TVNTLTQLAWALMLSMLTDRRDVVFGVTVSSRPAELARVESMVGLFVNTV Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 ---------MSADPTRTLLSMDLLDDDDHDRLDEWGNRAVLTE------- MAV_3243|M.avium_104 ---------MTVGAGRRLLSIDLLDGGEHDRLDEWGNRAILTK------- TH_3730|M.thermoresistible__bu -------------------------------------------------- MSMEG_3715|M.smegmatis_MC2_155 ---------MVGDPTRRLLSIDLLDDDEHDRLDDWGNRSALTR------- Mflv_2697|M.gilvum_PYR-GCK PLRVRLDPALTAGAQCRALQQDAATLRDHSYLGHAELRALAGVGELFDTL MMAR_0099|M.marinum_M PLRVRLDPKTTVAQQCALIQRDAARLREHAYLSHSQIRALAGMGELFDTL Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 ---------------------------PAAEPVSIPVVFAVQVERAPETV MAV_3243|M.avium_104 ---------------------------PVKAPASIPGMFAAQVARSAEAV TH_3730|M.thermoresistible__bu -------------------------------------------------- MSMEG_3715|M.smegmatis_MC2_155 ---------------------------PAAQQKTIPQLFSAQVTRTPTAH Mflv_2697|M.gilvum_PYR-GCK LVYENFPPGAVAGAGTLEAAGATFTPVALQSLAHFPVTIAAHLTDGRLTV MMAR_0099|M.marinum_M LVFQNFPSLGLADGKARAVGAARFDSLTVQSPTHFPVCITAELTDARLSL Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 ALVCRDR------------------------------------------- MAV_3243|M.avium_104 ALSFEGR------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- MSMEG_3715|M.smegmatis_MC2_155 ALVCGER------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK LVEAKDGALGQITPRALGTRLLATVSRIVEGWDRPLREISISPD------ MMAR_0099|M.marinum_M SIATNANAFGDITESALGDRLVAVLQRLLPMWDRPLRDVSMLLDGQTDGD Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- MSMEG_3715|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK ----------------------DHPVPVP--------------------- MMAR_0099|M.marinum_M TAVSEHARLDVVGNRAVLAEPLVEPVSVPGLFAAQVASRAEVTALVCGDR Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- MSMEG_3715|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M SLTYRELDRAANRLAHLLVDQGVGPGDVVGLLLERSVEAVIAILAVLKSG Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- MSMEG_3715|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M AAYLAIDVNHPDGRIGFMIEDAAPVAVITTAGLAQRLAGYPVAVIDIDDP Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- MSMEG_3715|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK ------------------------------------------------VS MMAR_0099|M.marinum_M AIATCYPGYGLPFPSADNIAYLIYTSGTTGKPKGVGITHHNITQLFTSVA Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- MSMEG_3715|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK EAAPTPSP------------------------------------------ MMAR_0099|M.marinum_M ATGFTPAPGQIWTQCHSYAFDYSVWEMWGALLHGGRLVVVPELVTRSAAE Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- MSMEG_3715|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M LLALLVTEGVGVLSQTPSAFYALQAEDAAQPQLGRQLCLDAVVFGGEALE Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- MSMEG_3715|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK ------------------------STGVHTRFTETA-------------- MMAR_0099|M.marinum_M PARLGPWLANHGRRPRLINMYGITETTVHASFREIVRHDLGFAVSPVGVP Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- MSMEG_3715|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M LANLAFFVLDGWLRPVPVGVAGELYVAGAGVGCGYWRRSGLTASRFVACP Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- MSMEG_3715|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M FGALGARMYRTGDVVRWGPDGQLQYVGRADEQVKIRGYRIELGEVAAALS Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- MSMEG_3715|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M QLDGVDQAVVIAREDRPGDKRLVGYLVGSVDAGQARAALAQALPAYMVPA Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- MSMEG_3715|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M AVVVVDSLPLTVNGKLDIRALPAPQYGATGSYRAPASPVEEVLAGIYAQV Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- MSMEG_3715|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M LGLDRVAVDQSFFDLGGDSLSAMRVVAAINKSLGGDLSVRALFDAPTVAE Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- MSMEG_3715|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M LAPGIGQGSGQWTPLVAGERPAVVPLSFAQQRLWFIDQLQGPSAVYNMAW Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- MSMEG_3715|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK SARLG--------------------------------------------- MMAR_0099|M.marinum_M SARLSGELDAAALGAAFADVVGRHESLRTVFRAVAGVAEQLVLGVEQVDV Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- MSMEG_3715|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M RWQIIDAQGWSSRRLAAALEQQARHCFDLTVEIPLRASLFRVTDDEHVLV Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- MSMEG_3715|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M VVAHHIAADGWSLRPLVTDLGVAYASRCAGRAPGWAGLAVQYVDYTLWQR Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- MSMEG_3715|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M TNLGELTDSHSGIAGQLRYWEKALEGMAERLQLPTDRAYPRVADHRGSGV Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- MSMEG_3715|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M DVQWPAQLQQQVARVAREHHATSFMVIQTALAVLLAKLSGSSDVAVGVPV Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- MSMEG_3715|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M AGRGDPALDELVGVFVNTVVLRVQVAGDPTFAQLLAQVRTRSLAAFEHQD Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- MSMEG_3715|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK ----------------------SVALSWD--------------------- MMAR_0099|M.marinum_M VPFEVLVERLNPVRSLTHHPLVQVVLAWQNDMSAELVLDGLDVEFAPVHT Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- MSMEG_3715|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK ------------------------GG------------------------ MMAR_0099|M.marinum_M QTARMDLVFSLGERFTDTGAPAGIGGGVEFRTDVFDAASIAALIQRLQRV Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- MSMEG_3715|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M VVAMVADPDRRLSSVDLLDAAEHARLDVVGNRAVLAEPLVEPVSVPGLFA Mb0104|M.bovis_AF2122/97 -------------------------MHRVRLSRSQRNLYNGVRQDNNPAL Rv0101|M.tuberculosis_H37Rv -------------------------MHRVRLSRSQRNLYNGVRQDNNPAL MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -----------------SWTYRELDQITNRIAHLLAGNGAGPGEVVGLLV MAV_3243|M.avium_104 -----------------SMTYRELDEASNRLAHLLAEQGAAPGECVALLF TH_3730|M.thermoresistible__bu -------------------------------------------------- MSMEG_3715|M.smegmatis_MC2_155 -----------------VFTYRELDEATDRLAMRLTRSGSGPGQCVALLL Mflv_2697|M.gilvum_PYR-GCK -----------------ALTYRQLDEAADRLAAVLTASGVRTETPVAVRL MMAR_0099|M.marinum_M AQVASRAEVTALVCEDRSLTYRELDRAANRLAHLLVDQGVGPGDVVGLLL Mb0104|M.bovis_AF2122/97 YLIGKSYRFRRLELARFLAALHATVLDNPVQLCVLENSGADYPDLVPRLR Rv0101|M.tuberculosis_H37Rv YLIGKSYRFRRLELARFLAALHATVLDNPVQLCVLENSGADYPDLVPRLR MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 PRSGEAIIGLLAILKTGAAYLPIDPAHPDERIKFMVSDAGPVAVLTTADL MAV_3243|M.avium_104 SRSDEAIVSILAVLKTGAAYLPIDPALPAARMEFMLGDATPIAAVTTAGL TH_3730|M.thermoresistible__bu --------------------------------------------VTTAEL MSMEG_3715|M.smegmatis_MC2_155 PRSAEAIIAILAVLKSGAAYLPMDTAHPDARLRFMLHDAKPVAAVTTSAL Mflv_2697|M.gilvum_PYR-GCK RRGADYVVAMFAVLKAGGAIVPLDPAMPADRIEVILRRAGVTVVVDEDTV MMAR_0099|M.marinum_M ERSVEAVIAILAVLKSGAAYLAIDVNHPDGRIGFMIEDAAPVAVITTAGL Mb0104|M.bovis_AF2122/97 FGDIVRVGSADEHLQSTWCSGILGKPLVRHTVHTDPNGYVTGLDVHTHHI Rv0101|M.tuberculosis_H37Rv FGDIVRVGSADEHLQSTWCSGILGKPLVRHTVHTDPNGYVTGLDVHTHHI MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 GSRFEGLDVSVIEIDDPLID---GQPSSALPTPEPDDLAYMTYTSGTTGV MAV_3243|M.avium_104 RDRLEGFDLPVIDVDEAAAEIERTQPSSALPGPSPDDIAYMIYTSGTTGT TH_3730|M.thermoresistible__bu GARLHRSGVPVIHIDDPAAPG--QAGATTGPAPAPDDIAYIIYTSGTTGV MSMEG_3715|M.smegmatis_MC2_155 HTRLTGTGIPLLDIDACDTG-----ASAPIRPPVPDDLAYLTYTSGTTGV Mflv_2697|M.gilvum_PYR-GCK ARATAEPP-------------AQYRPAETLPG----QAAYVVFTSGTTGE MMAR_0099|M.marinum_M AQRLAGYPVAVIDIDD--PAIATCYPGHGLPFPSADNIAYLIYTSGTTGK Mb0104|M.bovis_AF2122/97 LLDGGATGTIEADLARYLTTDPAGETPSVGAGLAKLREAHRRETAKVEES Rv0101|M.tuberculosis_H37Rv LLDGGATGTIEADLARYLTTDPAGETPSVGAGLAKLREAHRRETAKVEES MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 PKAVAVTHHNVTQLVD----AVRADLPARPGEVWSQWHSLVFDV-SVWEI MAV_3243|M.avium_104 PKGVAVTHRNVTEFLK----TLHPKLPSGPGQVWSQWHSLVFDV-SVWET TH_3730|M.thermoresistible__bu PKGVAVTHRNVAALLS----ALDAELAS--GQVWTQCHSLAFDF-SVWEI MSMEG_3715|M.smegmatis_MC2_155 PKAVAVTHRNVTQLLE----CPHPELPASPGQVWSQWHSLVFDV-SVWEI Mflv_2697|M.gilvum_PYR-GCK PKGVIGTHRALLAYADDHIGAILRPAADRVGRPLRIAHAWSFTFDAAWQP MMAR_0099|M.marinum_M PKGVGITHHNITQLFTSVAATGFTPAP---GQIWTQCHSYAFDY-SVWEM Mb0104|M.bovis_AF2122/97 RGRLSAVVQRELADEAYHGGHGHSVSDAPGTAAKGVLHESATICGNAFDA Rv0101|M.tuberculosis_H37Rv RGRLSAVVQRELADEAYHGGHGHSVSDAPGTAAKGVLHESATICGNAFDA MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 WGALLHGGRLVVVPESVASSPDDLHELLISEKVSVLCQTPSAAGMLS--- MAV_3243|M.avium_104 WGALLHGGRLVVVPESVAGSPDDLHDLLVAEGVTVLSQTPSAVGMLS--- TH_3730|M.thermoresistible__bu WGPLLYGGRVVIVPDPVVRSPEDLHALLAAEQVGMLSQTPSAFYALQTAD MSMEG_3715|M.smegmatis_MC2_155 CGALLHGNRLVVVPESIASSPHELNALLVRERVTVLCQTPSSAGMLS--- Mflv_2697|M.gilvum_PYR-GCK LAALLDGHSVHIVDDATQRDAEALVDTIARFGVDMIDTTPSMFARLRDVG MMAR_0099|M.marinum_M WGALLHGGRLVVVPELVTRSAAELLALLVTEGVGVLSQTPSAFYALQAED Mb0104|M.bovis_AF2122/97 ILTLSEAQRVPLNVLVAAAAVAVDASLRQNTETLLVHTVDNRFGDSDLNV Rv0101|M.tuberculosis_H37Rv ILTLSEAQRVPLNVLVAAAAVAVDASLRQNTETLLVHTVDNRFGDSDLNV MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 ---PE---RLESTTLIVAGEACPPELVDRWATS----GRTMINAYG---- MAV_3243|M.avium_104 ---PE---GLDSTALVVAGEACPAEVVDRWAP-----GRVMINAYG---- TH_3730|M.thermoresistible__bu SLQPEQARQLQLQTVVFGGEALEPQRLSAWMRN-HPERPRLINMYG---- MSMEG_3715|M.smegmatis_MC2_155 ---AEG---LDRTALVVAGEACPADLVQRWAP-----GRVMLNAYG---- Mflv_2697|M.gilvum_PYR-GCK LLSTVP-----LAVLALGGEAVDPGLWQQIRQECARTGMSAFNCYG---- MMAR_0099|M.marinum_M AAQPQLGRQLCLDAVVFGGEALEPARLGPWLANHGRR-PRLINMYG---- Mb0104|M.bovis_AF2122/97 ATCLVNSVAQTVRFPPFASVSDVVRTLDRGYVKAVRRRWLREEHYRRMYL Rv0101|M.tuberculosis_H37Rv ATCLVNSVAQTVRFPPFASVSDVVRTLDRGYVKAVRRRWLREEHYRRMYL MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -----------------------PTEATIYAAMSGP--LTPGSGVAPIGS MAV_3243|M.avium_104 -----------------------PTEATVYAAMSAP--LTAESGAPPIGS TH_3730|M.thermoresistible__bu -----------------------ITETTVHASFREIGAADLDDNTSPIGR MSMEG_3715|M.smegmatis_MC2_155 -----------------------PTEATVYAAMSSP--LSSDADPVPIGR Mflv_2697|M.gilvum_PYR-GCK -----------------------PTETTVEAVVAEIGAHER----PTIGR MMAR_0099|M.marinum_M -----------------------ITETTVHASFREIVRHDLGFAVSPVGV Mb0104|M.bovis_AF2122/97 AINRTSHVEALTLNFIREPCAPGLRPFLSEVPIATDIGPVEGMTVASVLD Rv0101|M.tuberculosis_H37Rv AINRTSHVEALTLNFIREPCAPGLRPFLSEVPIATDIGPVEGMTVASVLD MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 PVPGAALFVLDKWLRPAPEGVVGELYVAGNGVAPGYAHRSGLTASRFLAC MAV_3243|M.avium_104 PVPGAALFVLDKWLRPAPEGVVGELYIAGRGVATGYARRAGLTASRFVAC TH_3730|M.thermoresistible__bu PLPHLAFFVLDGWLRPVPPGVVGELYVAGAGLATGYVSRSDLTSTRFVAC MSMEG_3715|M.smegmatis_MC2_155 PVPHAAAFVLDKFLRPVLDGVIGELYIAGAGVAVGYARRSALTASRFVAC Mflv_2697|M.gilvum_PYR-GCK PTAPTRAYVLDSWLRPVPSGAAGELYLAGGQLTRGYLGRPGETAARFVPD MMAR_0099|M.marinum_M PLANLAFFVLDGWLRPVPVGVAGELYVAGAGVGCGYWRRSGLTASRFVAC Mb0104|M.bovis_AF2122/97 EEQRTLNLAIWNRADLPACKTHPKVAERIAAALESMAAMWDRPIAMIVND Rv0101|M.tuberculosis_H37Rv EEQRTLNLAIWNRADLPACKTHPKVAERIAAALESMAAMWDRPIAMIVND MUL_1722|M.ulcerans_Agy99 ---------------------------------MSPITREER-LERRIQD Mvan_2578|M.vanbaalenii_PYR-1 ---------------------------------MSTDTREDR-LARRIAD MLBr_00484|M.leprae_Br4923 -------------------MWRQQSISHRKESVMSTITKQEKQLARRVDD . : MAB_4098c|M.abscessus_ATCC_199 PFGGPGSRMYRTGDLVQWGEDGQLQYLGRADEQVKIRGYRIELGEIQAAL MAV_3243|M.avium_104 PFGGPGARMYRTGDLVRWGADGQLQYLGRADEQVKIRGYRIELGEIQSAL TH_3730|M.thermoresistible__bu PFGPPGTRMYRTGDLVRWDTGGELHYIGRADEQVKIRGYRIELGEIQAAL MSMEG_3715|M.smegmatis_MC2_155 PFGTPGQRMYRTGDLVRWDDDGHLVYLGRCDEQVKIHGYRIELGEVQAAL Mflv_2697|M.gilvum_PYR-GCK PF-VPGARMYRTGDVVRRAVDGTLAFLGRSDTQVKIRGFRVEPGEVAAVL MMAR_0099|M.marinum_M PFGALGARMYRTGDVVRWGPDGQLQYVGRADEQVKIRGYRIELGEVAAAL Mb0104|M.bovis_AF2122/97 WFGIGPDGTRCQGDWPARQPSTPAWFLDSARGVHQFLGRRRFVYPWVAWL Rv0101|M.tuberculosis_H37Rv WFGIGPDGTRCQGDWPARQPSTPAWFLDSARGVHQFLGRRRFVYPWVAWL MUL_1722|M.ulcerans_Agy99 LYANDPQ------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 LYATDPQ------------------------------------------- MLBr_00484|M.leprae_Br4923 LTANDPQ------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 SRLDGVEQAVVIAREDRPGDKRLVGYIMGTADPVEARNALAERLPAYMVP MAV_3243|M.avium_104 AALDGVDQAAVIAREDRPGDKRLVGYITGTADPAELRTQLGKRLPAYMVP TH_3730|M.thermoresistible__bu ARLDGVDQAAVIAREDRPGDKRLVGYITGTADPVQARAQLADRLPPYMVP MSMEG_3715|M.smegmatis_MC2_155 AGLDGVDQAVVTVREDRPGDQRLVGYIIGAADPSASRRALAERLPAYMVP Mflv_2697|M.gilvum_PYR-GCK RTHPAVGQAYVAVRPHRDG-HRLTAYVTGEPQLRELRAWLGRRLPRYLMP MMAR_0099|M.marinum_M SQLDGVDQAVVIAREDRPGDKRLVGYLVGSVDAGQARAALAQALPAYMVP Mb0104|M.bovis_AF2122/97 VQRGAAPGDVLVFTDDDTDKTIDLLIACHLAGCGYSVCDTADEISVRTNA Rv0101|M.tuberculosis_H37Rv VQRGAAPGDVLVFTDDDTDKTIDLLIACHLAGCGYSVCDTADEISVRTNA MUL_1722|M.ulcerans_Agy99 ----------------------------------FAAAKPVTAITAAIER Mvan_2578|M.vanbaalenii_PYR-1 ----------------------------------FAAAAPDDAISHAIDQ MLBr_00484|M.leprae_Br4923 ----------------------------------FAAAKPDPAVAAALAQ :. MAB_4098c|M.abscessus_ATCC_199 AAVVVLDALPLTVNGKLDKRALPAPEYRSVGTDYRAPSGPVEKVLADIYA MAV_3243|M.avium_104 AAVVVLESLPLTVNGKLDKRALPAPEYHKRAGQYRAPSNHTEEILADIYA TH_3730|M.thermoresistible__bu AAIVVLESIPLTSNNKLDVRALPAPEYRATGAEYRAPGTPLEGLLAGIFA MSMEG_3715|M.smegmatis_MC2_155 AAVVVLDSLPLTVNGKLDKRALPAPDYRGDAGSFRAPTSDVERILTDIYS Mflv_2697|M.gilvum_PYR-GCK NAIVAVDRIPLTAHGKIDEPALVALEPAADG-AATRPQTPTEVELAAVLA MMAR_0099|M.marinum_M AAVVVVDSLPLTVNGKLDIRALPAPQYGATG-SYRAPASPVEEVLAGIYA Mb0104|M.bovis_AF2122/97 ITEHGDGILVTVVDVAATQLAVVGHDELRKVVDERVTQVTHDALLATKTA Rv0101|M.tuberculosis_H37Rv ITEHGDGILVTVVDVAATQLAVVGHDELRKVVDERVTQVTHDALLATKTA MUL_1722|M.ulcerans_Agy99 PGLPLPQIIETVMTGYADRPALA----------QRSVEFVTDAGTGHTTL Mvan_2578|M.vanbaalenii_PYR-1 PGTHLPVIVQTVLDGYAERPALG----------QRAVRFVTDPATGRTTT MLBr_00484|M.leprae_Br4923 PGLRLPQIIQTALDGYAERPALG----------QRVAEFTKDPKTGRTSM : . *: : MAB_4098c|M.abscessus_ATCC_199 QVLGVDRVGVDESFFDLGGDSILSMQVVSRARAAGVHCRPRDIFVEQTVS MAV_3243|M.avium_104 QVLGVERVGVDDSFFDLGGDSILSMQVVARARAAGVICRPRDVFVEQTVA TH_3730|M.thermoresistible__bu EVLGVERVGVDDSFFDLGGDSILSMQVVARARAAGVQCRPRDIFVEQTVA MSMEG_3715|M.smegmatis_MC2_155 EVLGVDRVGVDDSFFALGGDSILSMRVVAQARMQGLRLRPRDVFVEQTVA Mflv_2697|M.gilvum_PYR-GCK EVLGVGEIDVTADFLELGLDSIVALSVVQTARRRGVVMRAKLMLDCATVR MMAR_0099|M.marinum_M QVLGLDRVAVDQSFFDLGGDSILAIQVVARARAAGVVCRPRDVFTEQTVA Mb0104|M.bovis_AF2122/97 YIMPTSGTTGQPKLVRISHGSLAVFCDAISRAYGWGAHDTVLQCAPLTSD Rv0101|M.tuberculosis_H37Rv YIMPTSGTTGQPKLVRISHGSLAVFCDAISRAYGWGAHDTVLQCAPLTSD MUL_1722|M.ulcerans_Agy99 RLLPH--------FETISYGELWDRISALADVLST--------------- Mvan_2578|M.vanbaalenii_PYR-1 ELLPR--------FETITYAELSRRIHAVTAALT---------------- MLBr_00484|M.leprae_Br4923 ELLPS--------FETITYRQLGDRVGALARAWR---------------- :: : : .: . MAB_4098c|M.abscessus_ATCC_199 G--------------------------------------VAAVASLSDGR MAV_3243|M.avium_104 R--------------------------------------LARVASDGADE TH_3730|M.thermoresistible__bu R--------------------------------------LASVVKVSGGE MSMEG_3715|M.smegmatis_MC2_155 R--------------------------------------LAATATLVSGQ Mflv_2697|M.gilvum_PYR-GCK --------------------------------------ELAAAIDDAGSG MMAR_0099|M.marinum_M GLA-----------------------------------TVAAVFDDANDD Mb0104|M.bovis_AF2122/97 ISVEEIFGGAACGARLVRSAAMKTGDLAALVDDLVARETTIVDLPTAVWQ Rv0101|M.tuberculosis_H37Rv ISVEEIFGGAACGARLVRSAAMKTGDLAALVDDLVARETTIVDLPTAVWQ MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 AGIVDDGIGPVLATPIIHWLQGVPGPVDQFNQTIVLQAPVG----VTEDD MAV_3243|M.avium_104 EQVVDEGIGPVQATPIMRWLQTVQGPIDDFNQTMVLAAPSG----VTADD TH_3730|M.thermoresistible__bu PETVDDGTGAVVATPIMRWLRGVDGPTDQFNQTVVLQAPPGTDTAAAEAD MSMEG_3715|M.smegmatis_MC2_155 REPGEDVTAPVTATPMMRWLQTVDGQVDQFHQAMVLQAPADAAG-CEFAD Mflv_2697|M.gilvum_PYR-GCK PPSADEGSGPIALLPNAHWLYEFGDP-RRLASTEALRLPRG----ITGPQ MMAR_0099|M.marinum_M GGHAEDSVGEVVATPIMLWLQSLDGPLKEFNQTALLQAPAA----MSYGD Mb0104|M.bovis_AF2122/97 LLCADGDAIDAIGRSRLRQIVIGGEAIRCSAVDKWLESAASQGISLLSSY Rv0101|M.tuberculosis_H37Rv LLCADGDAIDAIGRSRLRQIVIGGEAIRCSAVDKWLESAASQGISLLSSY MUL_1722|M.ulcerans_Agy99 ---------EQTVKPSDRVCLLGFNSVDYATIDMTLARLGAVAVPLQTSA Mvan_2578|M.vanbaalenii_PYR-1 -----------DVHPGDRVAVLGFTSIDYTTVDMALAMLGAVAVPLQTSA MLBr_00484|M.leprae_Br4923 ---------HDLLHAGYRVCVLGFNSVDYAIIDMALGVIGAVAVPLQTSA . * MAB_4098c|M.abscessus_ATCC_199 VVVILQALLDRHATLRLRAESG---DASGGWSLLVPDTGTVDARACLRVA MAV_3243|M.avium_104 VAVVLQALLDRHPMLRLRVED----DGAGGWNLQAPEPGSVRAADCLQSV TH_3730|M.thermoresistible__bu VVAVLQALIDRHPTLRMRAEGMTAGDGTDDWSLFIPEPGATSAREVMHTV MSMEG_3715|M.smegmatis_MC2_155 VVDVLQDLLDHHAALRLCASG-------DGPSAPVLEVGAVRAADCVQSV Mflv_2697|M.gilvum_PYR-GCK IRALLQSVVDAHPVLRTRLDR----AAMTLVDGGFDLP--LTEIEVGDEG MMAR_0099|M.marinum_M VIVSLQAVLDRHAMLRLQVDT----DATGRWLLHVPAPGCVDARKCVRAV Mb0104|M.bovis_AF2122/97 GPTEATVVATFLPIVCDQTTMDGALLRLGRPILPNTVFLAFGEVVIVGDL Rv0101|M.tuberculosis_H37Rv GPTEATVVATFLPIVCDQTTMDGALLRLGRPILPNTVFLAFGEVVIVGDL MUL_1722|M.ulcerans_Agy99 AITQLQPIVAETQPTMIAASVD---------ALADATELALSGQTATRVL Mvan_2578|M.vanbaalenii_PYR-1 PATTVRPIVAETEPVVIASSVD---------ALTDAVGLALDAPTVTRLV MLBr_00484|M.leprae_Br4923 AITQLQSIVTETEPSMIATSVN---------QLPDTVELILSGQAPAKLV : MAB_4098c|M.abscessus_ATCC_199 ESLSDAELVAARSRLNPAAGAQLSAVWVP--------DSRQLALMIHHLA MAV_3243|M.avium_104 DTLSDAVLVAARSRLNPGAGVMVSAVWAS--------ETSQLALIIHHVA TH_3730|M.thermoresistible__bu DTLTDEVLIAARSRLNPAAGVMLSAVWAR--------GSGQLVLMIHHLA MSMEG_3715|M.smegmatis_MC2_155 DTLCAETLAKARSRLNPAEGRLLSALWVP--------HTHQLVLMIHHIG Mflv_2697|M.gilvum_PYR-GCK SAAVARHAAAALEHLDPQRGPLWGAVWLRGSD-DADSTSSVLLLTAHVLA MMAR_0099|M.marinum_M TALSDDELVQARSRLDPSAGVMVSALWVT--------SSAQLALVIHHLA Mb0104|M.bovis_AF2122/97 VADGYLGIDGDGFGTVTAADGSRRRAFATGDRVTVDAEGFPVFSGRKDAV Rv0101|M.tuberculosis_H37Rv VADGYLGIDGDGFGTVTAADGSRRRAFATGDRVTVDAEGFPVFSGRKDAV MUL_1722|M.ulcerans_Agy99 VFDHHRQVDAHRAAVESARER----------------------------- Mvan_2578|M.vanbaalenii_PYR-1 VFDHRAGVDDHRDALISASDR----------------------------- MLBr_00484|M.leprae_Br4923 VFDYHPEVDEQHDAVATARAR----------------------------- . MAB_4098c|M.abscessus_ATCC_199 VDGVSWRILLEDLNIAWAQHHGGQPVQLPAGGTSFARWAALLDEHARSQD MAV_3243|M.avium_104 VDGVSWRTLIEDLNIAWAQHHSGQPVALPAGGTSFARWSSLLAEHALTPA TH_3730|M.thermoresistible__bu VDGVSWRILVEDLNIAWAQHRTGQPIDLPANGTSFARWSALLADHARAPE MSMEG_3715|M.smegmatis_MC2_155 VDGVSWRILLEDLNIAWAQRRAHQRVELPAEGTSLAHWSALLQKHAYSPE Mflv_2697|M.gilvum_PYR-GCK MDPVSWQIVIGELDAGWHALAGGRAPAALGEHTGYRQWSNLLRERAESS- MMAR_0099|M.marinum_M IDGVSWRILLDDLNSVWEQHRSGEMAALPAGGTSFRRWAALLAEQAYSAT Mb0104|M.bovis_AF2122/97 VKISGKRVDIAEVTRRIAEDPAVSDVAVELHSGSLGVWFKSQRTREGEQD Rv0101|M.tuberculosis_H37Rv VKISGKRVDIAEVTRRIAEDPAVSDVAVELHSGSLGVWFKSQRTREGEQD MUL_1722|M.ulcerans_Agy99 LAGS---AVVETLAEAIARGDVPRGASAGSAPGTD--------------- Mvan_2578|M.vanbaalenii_PYR-1 LRAANSPIEVETITDIVARGSKLPVRAQFSADG----------------- MLBr_00484|M.leprae_Br4923 LADSS--VVVESLTEVLGRGKTLPATPIPVADDS---------------- : : : MAB_4098c|M.abscessus_ATCC_199 VVATADAWREVTAVPAALPAVMPGLDTYATAKTLSVSLDADTTRELLSEV MAV_3243|M.avium_104 VVEQADAWREVVATPAVLPAVQPEVDTYQSAEQLSVSLDVDTTRLLLGEV TH_3730|M.thermoresistible__bu VVEHVEAWQRVIAAPSALPAIRPERDTYATAGQLSVSLDADTTRQLLGAV MSMEG_3715|M.smegmatis_MC2_155 VVAQAGAWQKVLSIATPLPETQPAVDTYATAGHLSVSLDSETTRQLLGDV Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M AVDHAAAWRQVLATPSVLPAVKPAVDTYATAQRLLVSLDIETTRTLLAAA Mb0104|M.bovis_AF2122/97 AAAATRIRLVLVSLGVSSFFVVGVPNIPRKPNGKIDSDNLPRLPQWSAAG Rv0101|M.tuberculosis_H37Rv AAAATRIRLVLVSLGVSSFFVVGVPNIPRKPNGKIDSDNLPRLPQWSAAG MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 PAAFHAGVQDILLIAFGLAWNEFLDSNTTSIGIGVEGHGRQEELGRVAGL MAV_3243|M.avium_104 PAAFHAGVQDILLIAFAMAWTQVVGAG-TPIGIDVEGHGRHEELG----P TH_3730|M.thermoresistible__bu PAAFHAGVQDILLIAFGLAWAEFLGACDSPIGIDVEGHGRAEELA----A MSMEG_3715|M.smegmatis_MC2_155 PAAFHAGVGDIMLIAYALAWNEFRGGGSASITIDVEGHGRDEELGDVFGE Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M PAAFHAGVQDILLIAFALAWSEFSSGGGSRIAIDVEGHGRHEELA----F Mb0104|M.bovis_AF2122/97 LNTAETGQRAAGLSQIWSRQLGRAIGPDSSLLGEGIGSLDLIRIL----- Rv0101|M.tuberculosis_H37Rv LNTAETGQRAAGLSQIWSRQLGRAIGPDSSLLGEGIGSLDLIRIL----- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 DIDLSRTVGWFTTKYPVSLSVGGLSWKEIADGSPDLGPIIKSAKEQLRAL MAV_3243|M.avium_104 HVDLSRTVGWFTTKYPVALAIDGLDWASVVAGDDALGAAVKAAKEQLRAL TH_3730|M.thermoresistible__bu GVDLSRTVGWFTTKYPVALTIPKLSWEQVRTGGDALGAAVKAAKEQLRSV MSMEG_3715|M.smegmatis_MC2_155 DIDLSRTVGWFTTKYPVAITVAPLRWDLVRDGAPALGAMIKSAKEQLHSL Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M GVDLSHTLGWFTTKYPVAVSVGALRWAQVVAGDAALGAVVKDAKEQLRGL Mb0104|M.bovis_AF2122/97 --------------------------------PETRRYLGWRLSLLDLIG Rv0101|M.tuberculosis_H37Rv --------------------------------PETRRYLGWRLSLLDLIG MUL_1722|M.ulcerans_Agy99 ------------------------------------------------VS Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 PDPLTYGLLRYLNPDVDLSGPEPAIGFNYLGRLGAGAADLTDDLWRINED MAV_3243|M.avium_104 PDGLTYGLLRYLNPDVDLGGSDPVIGFNYLGRLGA-AADLPGELWRLSPD TH_3730|M.thermoresistible__bu PDGITYGLLRHLNPDVELGGAEPAIGFNYLGRLAAGAGDLPDELWRIDPS MSMEG_3715|M.smegmatis_MC2_155 PGTSTYGLLRHLNTDVDLSGPEPTIGFNYLGRVGA--DHLGDRLWRIDPD Mflv_2697|M.gilvum_PYR-GCK -DGLQFWLD-------QLGGPDPALGARRVR------------------- MMAR_0099|M.marinum_M PDGLLYGLIRYLNREVELAGAEPTIGFNYLGRLSTRTTAGDDHWQIARWG Mb0104|M.bovis_AF2122/97 ADTAANLADYAPTPDAPTGEDRFRPLVAAQRPAAIPLSFAQRRLWFLDQL Rv0101|M.tuberculosis_H37Rv ADTAANLADYAPTPDAPTGEDRFRPLVAAQRPAAIPLSFAQRRLWFLDQL MUL_1722|M.ulcerans_Agy99 DDSLALLIYTSGSTGAPKG------AMYPRRNVATFWR---KRTWFEGGY Mvan_2578|M.vanbaalenii_PYR-1 -DALSLLIYTSGSTGAPKG------AMYPQHLVANSWRRLARSFWGDLGV MLBr_00484|M.leprae_Br4923 ADPLALLIYTSGSTGAPKG------AMYLQSNVGKMWRR-SDGNWFGP-T . . MAB_4098c|M.abscessus_ATCC_199 SLSSAGVAS-SVSMPLMYTVDLNAGIVEGGL-GEEAGPHLRAGWTWAPSS MAV_3243|M.avium_104 SLSLSGAAA-AVAMPLMHTVDLNAGTMD-----TEDGPHLHANWTWAPSA TH_3730|M.thermoresistible__bu GLPITEAAS-KIPMPLAHTVEVNAGTLDAG----PDGPVLQATWTWAPSL MSMEG_3715|M.smegmatis_MC2_155 GLALAEVAS-AVPMPLMHTLELNAGTLQVDSPAGTPEPALQAAWTWAPSA Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M SLFTDECASAELPIQLFHTVELDAVTFDTEA-----GPQLHAQWTWATSA Mb0104|M.bovis_AF2122/97 QRPAPVYN------------------------------------------ Rv0101|M.tuberculosis_H37Rv QRPAPVYN------------------------------------------ MUL_1722|M.ulcerans_Agy99 EPSITLNF------------------------------------------ Mvan_2578|M.vanbaalenii_PYR-1 FPAITLNF------------------------------------------ MLBr_00484|M.leprae_Br4923 AASITLNF------------------------------------------ MAB_4098c|M.abscessus_ATCC_199 VTEPQVQRLSQLWFEALAGICAYVRGGGGGLTPSDIAPAQLSQQQIDELH MAV_3243|M.avium_104 VDRDQISRLSQLWFEALAGICAHVRAGGGGLTPSDILPARLNQRQIDELS TH_3730|M.thermoresistible__bu VDEAQIARLSRLWFEALGGVCAHVRSGGGGLTPSDIAPARLTQQQIDELA MSMEG_3715|M.smegmatis_MC2_155 VDEAQVKRLSQLWFEALTGICAHVRSGGGGWTPSDIAPAVLTQSQIDQIA Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M LDRAQLNRISRLWFEALTGICAHVRAGGGGMTPSDIGLTRLSQHQIDQLE Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 EQHKIVDVLPLTPIQEGLLFHTTFARAAGALEGDEAGIDFYAVQLDITVT MAV_3243|M.avium_104 KQHQIADILPLTPLQQGLLFHASFAQDP--------GDDVYAVQLGITVT TH_3730|M.thermoresistible__bu DRHDIADILPLTPVQQGLLFHSAVTRTT--------ADDIYAVQLDLTIA MSMEG_3715|M.smegmatis_MC2_155 EQYRVADILPLTPLQQGLFFHSLIGPGE-------ASTDVYAVQLDITVT Mflv_2697|M.gilvum_PYR-GCK ---------------------PDTDRAG---------D----VRVTVTVT MMAR_0099|M.marinum_M QRYCVADVLPLTPLQQGLLFHADAARGG---------ADLYVVQFDITLS Mb0104|M.bovis_AF2122/97 --------MAVALRLRGYLDTEALGAAV-----------------ADVVG Rv0101|M.tuberculosis_H37Rv --------MAVALRLRGYLDTEALGAAV-----------------ADVVG MUL_1722|M.ulcerans_Agy99 --------MPMSHVMGRQILYGTLCNGG-----------------TAYFV Mvan_2578|M.vanbaalenii_PYR-1 --------MPMSHVMGRGLLYGTLDAGG-----------------TAYFA MLBr_00484|M.leprae_Br4923 --------MPMSHVMGRGILYGTLGNGG-----------------TAYFA . MAB_4098c|M.abscessus_ATCC_199 GLVDQLRLRDAVHTVVRRHPNLAARFCT--QFGDPVQVILADPVIAWRYL MAV_3243|M.avium_104 GALDSHRLHDAVHTVVNRHPNLAARFCP--QYGEPVQVVPADPVMAWRYI TH_3730|M.thermoresistible__bu GVVDQHRLRDAVHAVVARHPNLAARFCT--DHDHPVQIIPTEPVAAWRYL MSMEG_3715|M.smegmatis_MC2_155 GLLDADRLHDALLTVLRRHPNLVARFCG--DFDPPVQIIPDDPVMAWRYM Mflv_2697|M.gilvum_PYR-GCK GADVTARLLAGPHPVLD--------------------------------- MMAR_0099|M.marinum_M GALDPRRLRTAAQEVLRRHPNLAAQFVWGEPLDEPVQIILNDLVLEWRTV Mb0104|M.bovis_AF2122/97 RHESLRTVFPAVDGVPRQLVIEARRADLGCDIVDATAWPADRLQRAIEEA Rv0101|M.tuberculosis_H37Rv RHESLRTVFPAVDGVPRQLVIEARRADLGCDIVDATAWPADRLQRAIEEA MUL_1722|M.ulcerans_Agy99 VKSDLSTLFEDLALVR---------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 ARSDLSTFLEDLALVR---------------------------------- MLBr_00484|M.leprae_Br4923 ARSDLSTLLEDLKLVR---------------------------------- . * MAB_4098c|M.abscessus_ATCC_199 DLRGD---DLTPDEEIQHLCAAERAAVCDLADRPTLRAALIRTEGNQHRF MAV_3243|M.avium_104 QLGPE---DVDPEQKVEELCAAERAAVSDLANRPAFRAALIRTADNRHRF TH_3730|M.thermoresistible__bu DLRGD---DQNPEHEVQQLCAAERAAVRDLTERPTFRAALIRTGATEHRF MSMEG_3715|M.smegmatis_MC2_155 DLRED---DRPPEVEIEKLCTAERVAVCHLTDRPAFRAALIRTAGNQHRF Mflv_2697|M.gilvum_PYR-GCK ------------------------VLVAALG------------------- MMAR_0099|M.marinum_M EFDPAGDPDAHVEQHIDEVCADERVAVADLGGGSPFRIALIRTAPCEHRL Mb0104|M.bovis_AF2122/97 ARHSF----------------DLATEIPLRTWLFRIADDEHVLVAVAHHI Rv0101|M.tuberculosis_H37Rv ARHSF----------------DLATEIPLRTWLFRIADDEHVLVAVAHHI MUL_1722|M.ulcerans_Agy99 -----------------------PTELTFVPRVWDMVFDEFQSEVDRRLV Mvan_2578|M.vanbaalenii_PYR-1 -----------------------PTQLSFVPRIWDTIHAEVSQELERRPS MLBr_00484|M.leprae_Br4923 -----------------------PTELNFVPRIWETLYDESKRAVDRRLA . : MAB_4098c|M.abscessus_ATCC_199 VLTFHHVVIDGWSLPILLQEIFASYFGHRLPAPSSYRSFVSWLADQDLDA MAV_3243|M.avium_104 VLTNHHIVMDGWSLPILLREILAIYYGDQLPAPATYRSYLTWLAGQDRSA TH_3730|M.thermoresistible__bu VLTVHHIVIDGWSLPILLQEIFAGYFGQRLPAPARFRDFVTWLAAQDRDA MSMEG_3715|M.smegmatis_MC2_155 VMTFHHIVVDGWSLPILLKEIFGAYFEHRLPAPRPYRDFVGWLSAQDHDA Mflv_2697|M.gilvum_PYR-GCK ------------------------------------RTITEWRGRRNQPT MMAR_0099|M.marinum_M VLTAHHIVCDGWSMPIVMQEILAAYAGQPLAAPGSYRNFLTWLAERDKSA Mb0104|M.bovis_AF2122/97 AADGWSVAPLTADLSAAYASRCAGRAPDWAPLPVQYVDYTLWQREILGDL Rv0101|M.tuberculosis_H37Rv AADGWSVAPLTADLSAAYASRCAGRAPDWAPLPVQYVDYTLWQREILGDL MUL_1722|M.ulcerans_Agy99 DG--ADRVALEAQVKAEIRNDVLG-------------------------- Mvan_2578|M.vanbaalenii_PYR-1 D---------ATEVIADLRRSLLG-------------------------- MLBr_00484|M.leprae_Br4923 NSGSADRAAIKAEVMDEQRQSLLG-------------------------- MAB_4098c|M.abscessus_ATCC_199 ARTAWGKVLEGFDTPTLVAPP--APPGARGVESYRVSAETTQALGDLARS MAV_3243|M.avium_104 AQAAWRQVLDGFDTPTLVGPAGRMRLGRRAVESYRLSADTTRALGELARA TH_3730|M.thermoresistible__bu ARAAWRELLDGFDTPTLIAPP--GQAGPRGSASYRIDTETTAAIGELART MSMEG_3715|M.smegmatis_MC2_155 ARAAWHEVMGGFASPTVLTHP--GPPGPRRAHTYHVPAETTRAVGDLARS Mflv_2697|M.gilvum_PYR-GCK P-------------PPLVALETHG-------------------------- MMAR_0099|M.marinum_M ARTAWRELFADFRHPTLVGLPDHLGLGSRGVESYLLPIGITEALTELARS Mb0104|M.bovis_AF2122/97 DDSDSPIAAQLAYWENALAGMPERLRLPTARPYPPVADQRGASLVVDWPA Rv0101|M.tuberculosis_H37Rv DDSDSPIAAQLAYWENALAGMPERLRLPTARPYPPVADQRGASLVVDWPA MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 QHTTVSTVLQAAWAQLLMVLTGQDDVAFGTAVSG----------RPAELA MAV_3243|M.avium_104 CHTTVNTVLQAGWAQLLMRLTGQHDVAFGTAVSG----------RPADLA TH_3730|M.thermoresistible__bu QRTTVNTVLQAAWAHLLMAMTGQRDVVFGTAVSG----------RPADLP MSMEG_3715|M.smegmatis_MC2_155 CRTTVNTVLQAAWAQLLMALTGQHDVAFGTAVSG----------RPAELA Mflv_2697|M.gilvum_PYR-GCK ------------------------RAALAEADTA----------DTADTA MMAR_0099|M.marinum_M CRVTVNIVLQAAFAQLLSWLTGQHDVAFGTTVSG----------RPAEVA Mb0104|M.bovis_AF2122/97 SVQQQVRRIARQHNATSFMVVAAGLAVLLSKLSGSPDVAVGFPIAGRSDP Rv0101|M.tuberculosis_H37Rv SVQQQVRRIARQHNATSFMVVAAGLAVLLSKLSGSPDVAVGFPIAGRSDP MUL_1722|M.ulcerans_Agy99 -------------------------GRYTSALTG----------SAPISD Mvan_2578|M.vanbaalenii_PYR-1 -------------------------GRYVTAMTG----------SAPLSP MLBr_00484|M.leprae_Br4923 -------------------------GRYIAAMTG----------SAPTSP :. MAB_4098c|M.abscessus_ATCC_199 GSDSIVGLLINTVPVRARATASTTIAELLGQLQS---AHNDTIEHEHLAL MAV_3243|M.avium_104 GAESMVGLLINTVPVRANTHAETTVADLLDQLQQ---HHNDTLEHEHLAL TH_3730|M.thermoresistible__bu GADRIVGLLINTIPVRARIGADTTVADLLAQLQH---AHNDTLEHEHLAL MSMEG_3715|M.smegmatis_MC2_155 GSDSLVGLLINTIPVRANVPPTASVSDLLDQLQR---THNATVDHEYMSL Mflv_2697|M.gilvum_PYR-GCK DTSDTVGLLSAIYPLRLHEDSPGATTELIAGVPAG-GIDYGLLRYLRPDT MMAR_0099|M.marinum_M GVHSMVGLFINTVPTRARMASTTTTRELLDQLQS---VHYETLEHHHLAL Mb0104|M.bovis_AF2122/97 ALDNLVGFFVNTLVLRVNLAGDPSFAELLGQVRARSLAAYENQDVPFEVL Rv0101|M.tuberculosis_H37Rv ALDNLVGFFVNTLVLRVNLAGDPSFAELLGQVRARSLAAYENQDVPFEVL MUL_1722|M.ulcerans_Agy99 EMKAWVEELLDMHLVEGYGSTEAGMILIDGAIRRPAVLDYKLVDVPDLGY Mvan_2578|M.vanbaalenii_PYR-1 EMRAFVENLLDVHLIDGYGSTEAGAVFVDGRVQRPPVIDYKLVDVADLGY MLBr_00484|M.leprae_Br4923 ELKHGVESLLEMHLLEGYGSTEAGMVLFDGEVQRPPVIDYKLVDVPDLGY * : . : MAB_4098c|M.abscessus_ATCC_199 NEIHHVAGHEQLFDTLFLYESYPIDTSAFMGVQELAITEFVTREYNHYPL MAV_3243|M.avium_104 SEIHRVTGHDALFDTLFLYENYPIDTSVPLGFHELAITDVTNREYNHYPL TH_3730|M.thermoresistible__bu TEIHHLAGHDQLFDTLFLYESYPIDTGAFSGAQELAVTGFTNREFNHYPL MSMEG_3715|M.smegmatis_MC2_155 NEIHRITGHDQLFDTLFVYESYPFDAGAFAGTHELAITDFTTREHNHYPL Mflv_2697|M.gilvum_PYR-GCK S------------------------------------------------E MMAR_0099|M.marinum_M SDIHRVSGHDQLFDTLFVYENYPIDKTAAQGTGELAISGIGCREYSHYPL Mb0104|M.bovis_AF2122/97 VDRLKPTRALTHHPLIQVMLAWQDNPVGQLNLGDLQATPMPIDTRTARMD Rv0101|M.tuberculosis_H37Rv VDRLKPTRALTHHPLIQVMLAWQDNPVGQLNLGDLQATPMPIDTRTARMD MUL_1722|M.ulcerans_Agy99 FLTDRP------HPRGELLVKTDSLFPGYYQRAEVTADVFDADGFYRTGD Mvan_2578|M.vanbaalenii_PYR-1 FSTDRP------HPRGELLVKSETLFPGYYKRPDVTAEMFDEDGYYRTGD MLBr_00484|M.leprae_Br4923 FSTDQP------YPRGELLLKTQNMFPGYYKRPEVTATVFDSDGYYQTGD MAB_4098c|M.abscessus_ATCC_199 SVMALPGHE--------LGIRVEYDTDKFGLDDIQAVFERFERVLVSMVS MAV_3243|M.avium_104 SVMALPGRE--------LGLRVEFDTDVFDAAGIEKLTERFQRVLSEMTA TH_3730|M.thermoresistible__bu SVMALPGHE--------LGLRIEYDTEVFDTAAIDALADRFRRVLESMVG MSMEG_3715|M.smegmatis_MC2_155 SVIAIPGHE--------LGLRAEFDSVRFTDDDIEELIERFLRVLAAMID Mflv_2697|M.gilvum_PYR-GCK VLKAHPEPQ--------ILLNYLGRTDLVPSGAIVADRLLLS-------- MMAR_0099|M.marinum_M VVQAMPGDQ--------LGLRVEFRTDVFDAASIAALIQRLQRVVVAMVA Mb0104|M.bovis_AF2122/97 LVFSLAERFSEGSEPAGIGGAVEYRTDVFEAQAIDVLIERLRKVLVAVAA Rv0101|M.tuberculosis_H37Rv LVFSLAERFSEGSEPAGIGGAVEYRTDVFEAQAIDVLIERLRKVLVAVAA MUL_1722|M.ulcerans_Agy99 IMAEVGPEQ--------------------------FVYLDRRNNVLKLSQ Mvan_2578|M.vanbaalenii_PYR-1 IVAETGADQ--------------------------LTYLDRRNNVLKLSQ MLBr_00484|M.leprae_Br4923 IVAEVGPDR--------------------------LVYVDRRNNVLKLAQ : MAB_4098c|M.abscessus_ATCC_199 DADQRLSSLDVLQTDEHKQLDGWGNRKVLVRGPEPVLSIPEAFAEQVDRA MAV_3243|M.avium_104 DPTRRLTSLEVMDEAEHELLDAWGNRPVLS-QPATGTSIPALFAAQVART TH_3730|M.thermoresistible__bu DPARRLSAIEVLDAAEREQLDAWSNRAVLADSPALES-IPEVFARQVARD MSMEG_3715|M.smegmatis_MC2_155 DPERRVSTIDVLGTSERERLDSWCRRERLRGKGSGSSSIPERFSAQVVRT Mflv_2697|M.gilvum_PYR-GCK ----GLSTVPEPNAAVRHELTVV---------------------AAVVAH MMAR_0099|M.marinum_M DPDRRLSSVDLLDAAEHARLDVVGNRAVLAEPLVEPVSVPGLFAAQVASR Mb0104|M.bovis_AF2122/97 APERTVSSIDALDGTERARLDEWGNRAVLTAPAPTPVSIPQMLAAQVARI Rv0101|M.tuberculosis_H37Rv APERTVSSIDALDGTERARLDEWGNRAVLTAPAPTPVSIPQMLAAQVARI MUL_1722|M.ulcerans_Agy99 GEFVTVSKLEAVFGDS-------------------PLVRQIYIYGNSARA Mvan_2578|M.vanbaalenii_PYR-1 GEFVTVSRLEAVFGNS-------------------PLVRQIYVYGNSARP MLBr_00484|M.leprae_Br4923 GQFVTVAKLEAAFSNS-------------------PLVRQIYIYGNSAHP :: : MAB_4098c|M.abscessus_ATCC_199 PEAVALTFEGRSTTYGELDEAANRLANLLSVYGAAPGESVALLMPRSDEA MAV_3243|M.avium_104 PDAAALTFQGRSMSYRELDEASNRLAHLLIEEGAGPGECVALLFSRSAEA TH_3730|M.thermoresistible__bu PGAVAVTFEGRSMTYGELDDAATELANLLAVYGAGPGESVALLMPRSADA MSMEG_3715|M.smegmatis_MC2_155 PDSVAVTCGGESLTYAELDETADRLANLLTLHGAGPGTYVAIMLPRCAQA Mflv_2697|M.gilvum_PYR-GCK GDEPALVAQWRVLPEILSDTDVEEMQTIWQDT------------------ MMAR_0099|M.marinum_M AEVTALVCGDRSLTYRELDRAANRLAHLLVDQGVGPGDVVGLLLERSVEA Mb0104|M.bovis_AF2122/97 PEAEAVCCGDASMTYRELDEASNRLAHRLAGCGAGPGECVALLFERCAPA Rv0101|M.tuberculosis_H37Rv PEAEAVCCGDASMTYRELDEASNRLAHRLAGCGAGPGECVALLFERCAPA MUL_1722|M.ulcerans_Agy99 YLLAVIVPTQEALDAVPVEELKARLGDSLQEVAKAAG------------- Mvan_2578|M.vanbaalenii_PYR-1 YLLAVVVPTEAALAGA---DAKAAVAESLQDVAKATG------------- MLBr_00484|M.leprae_Br4923 YLLAVVVPTEDALATNDIEVLKPLIIDSLQKVAKEAD------------- .: : MAB_4098c|M.abscessus_ATCC_199 IIAILAILKTGASYLPIDPSVPDTRLEFMLSDAVPIAAVTTAELRARFDG MAV_3243|M.avium_104 IVSILAVLKTGAAYLPIDPALPAARIEFLLGDAEPVAVVTTAALRSRLDG TH_3730|M.thermoresistible__bu IVAILAVLKTGAAYLPIDPAVPAARLEFMLSDAEPIVALTTVELGTRFNG MSMEG_3715|M.smegmatis_MC2_155 IVAILAVLKTGAAYLPIDPVLPDARVQFMLDDTAPIAAVTNDELRSRFDG Mflv_2697|M.gilvum_PYR-GCK ---LREVL------------------------------------------ MMAR_0099|M.marinum_M VIAILAVLKSGAAYLAIDVNHPDGRIGFMIEDAAPVAVITTAGLAQRLAG Mb0104|M.bovis_AF2122/97 VVAMVAVLKTGAAYLPIDPANPPPRVAFMLGDAVPVAAVTTAGLRSRLAG Rv0101|M.tuberculosis_H37Rv VVAMVAVLKTGAAYLPIDPANPPPRVAFMLGDAVPVAAVTTAGLRSRLAG MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 SGVSVVQFDDAEDDPTGAIYGHTPLLTPAPDDIAYTIYTSGTTGVPKGVA MAV_3243|M.avium_104 CKPSVVDVDDPALDGQ----PSAALPVPSSDNIAYLIYTSGTTGVPKGVA TH_3730|M.thermoresistible__bu TGVPIIEVDDPAPPMY----PSSTLLPPAPDDIAYLIYTSGTTGVPKGVA MSMEG_3715|M.smegmatis_MC2_155 FAGVVVEADDPAMSLH----PTTALLAPAADDIAYVIYTSGTTGRPKGVA Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M YPVAVIDIDDPAIATCY---PGHGLPFPSADNIAYLIYTSGTTGKPKGVG Mb0104|M.bovis_AF2122/97 HDLPIIDVVDALAAYPG-----TPPPMPAAVNLAYILYTSGTTGEPKGVG Rv0101|M.tuberculosis_H37Rv HDLPIIDVVDALAAYPG-----TPPPMPAAVNLAYILYTSGTTGEPKGVG MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 IAHSNVTQALKFPLTH-MPTGPGEVWTQAGSLVFDITVWEIFGALLHGGR MAV_3243|M.avium_104 VSHDNVAQLVESLHAD-LPEG--GVWAQWHSLVFDVSVHEIWGALLHGGR TH_3730|M.thermoresistible__bu ITHANVTRVLHTLPAD-LPAGPGKVWSQWHSLVFDVSVWEIWGALLHGGR MSMEG_3715|M.smegmatis_MC2_155 VTHHNVTRLFDAPYPG-LTFGSGQVWTQCHSTGFDFSVWEIWSALLHGGR Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M ITHHNITQLFTSVAATGFTPAPGQIWTQCHSYAFDLSVFEMWGALLHGGR Mb0104|M.bovis_AF2122/97 ITHRNVTRLFASLPAR---LSAAQVWSQCHSYGFDASAWEIWGALLGGGR Rv0101|M.tuberculosis_H37Rv ITHRNVTRLFASLPAR---LSAAQVWSQCHSYGFDASAWEIWGALLGGGR MUL_1722|M.ulcerans_Agy99 ----------------------LQSYEIPRDFIIETTPWTLQNGLLTGIR Mvan_2578|M.vanbaalenii_PYR-1 ----------------------LQSYEIPRDFLLETTPFTLENGLLTGIR MLBr_00484|M.leprae_Br4923 ----------------------LQSYEVPRDLIVETTPFSLENGLLTGIR MAB_4098c|M.abscessus_ATCC_199 LVIIPDSVVRSPDDFRDLLIREKVTVLFQTPSAVGMLSPEGLNNLTLVVA MAV_3243|M.avium_104 LVVVPESVAASPDELHDLLVAEGVTVLSQTPSAVGMLSPEGLDSTALVVA TH_3730|M.thermoresistible__bu LVIVPESITGSPDDLHDLLVAEHVDVVYQTPSAAGMLSQRGLDSTALVVA MSMEG_3715|M.smegmatis_MC2_155 LVVVPESVTSSPSDLHELLVTEHVTMFSQTPAAAAALSHTGLEDLTLVVG Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M LVVVPESVTGSPADLHALLVAEQVDVLAQTPSAVAMLSTQGLESTTLVVG Mb0104|M.bovis_AF2122/97 LVIVPESVAASPNDFHGLLVAEHVSVLTQTPAAVAMLPTQGLESVALVVA Rv0101|M.tuberculosis_H37Rv LVIVPESVAASPNDFHGLLVAEHVSVLTQTPAAVAMLPTQGLESVALVVA MUL_1722|M.ulcerans_Agy99 KLARPQ-------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 KLARPR-------------------------------------------- MLBr_00484|M.leprae_Br4923 KLAWPK-------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 GEACPTEVVDRWAPGRVMINGYGPTETTIYATFG-ELIAGS-GVVPIGVP MAV_3243|M.avium_104 GEACPVEIVDRWAPGRVMINAYGPTEATVYAAMSTPLQPGT-GSAPIGSP TH_3730|M.thermoresistible__bu GEACPTDLVDRWAPGRVMINAYGPTETTMCVAISAPLTPGS-GAVPIGTP MSMEG_3715|M.smegmatis_MC2_155 GEACPSEVVQRWAPKRTMINGYGPTETTVFASTSEPLNPSSPGDVPIGAP Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M GEACPAEVVDNWAPGRMMVNQYGPSETTMYVSMSAPLVPGS-GPAPIGVP Mb0104|M.bovis_AF2122/97 GEACPAALVDRWAPGRVMLNAYGPTETTICAAISAPLRPGS-GMPPIGVP Rv0101|M.tuberculosis_H37Rv GEACPAALVDRWAPGRVMLNAYGPTETTICAAISAPLRPGS-GMPPIGVP MUL_1722|M.ulcerans_Agy99 -----------------LKKHYGELLEQIYTDLAH--------------- Mvan_2578|M.vanbaalenii_PYR-1 -----------------LRERYGEQLEALYTMLSE--------------- MLBr_00484|M.leprae_Br4923 -----------------LKQHYGARLEQLYADLVE--------------- MAB_4098c|M.abscessus_ATCC_199 VPDAALFVLDRWMRPVPPGVVGELYVAGLGVGIGYVKRQALTAARFVACP MAV_3243|M.avium_104 VPRAALFVLDRWLRPAPPGVVGELYIAGHGVATGYARRSGLTASRFVACP TH_3730|M.thermoresistible__bu VPRAALFVLDSWMRPVPAGVIGELYVAGDGVAVGYVGRSELTASRFVACP MSMEG_3715|M.smegmatis_MC2_155 VPGAAVFVLDSWLRPVPPGVAGEVYVAGGGVTVGYVHRPGMTASRFVACP Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M VPRAALFVLDGWLRPVPAGVAGELYVAGAGVGCGYWRRSGLTASRFVACP Mb0104|M.bovis_AF2122/97 VSGAALFVLDSWLRPVPAGVAGELYIAGAGVGVGYWRRAGLTASRFVACP Rv0101|M.tuberculosis_H37Rv VSGAALFVLDSWLRPVPAGVAGELYIAGAGVGVGYWRRAGLTASRFVACP MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 FGEPGTRMYRTGDLVR---WGVSESSVGQLEYLGRADEQVKIRGFRIELG MAV_3243|M.avium_104 FGGPGARMYRTGDLVR---WNQD----GQLEYLGRADEQVKLRGYRIELG TH_3730|M.thermoresistible__bu FGPPGSRMYRTGDLVR---WGAD----GQLQYLGRADEQVKIRGYRIELG MSMEG_3715|M.smegmatis_MC2_155 FAADGSRMYRTGDLAR---WGTD----GQLRYLGRADDQVKIRGFRIELG Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M FGALGARMYRTGDVVR---WGPD----GQLQYVGRADEQVKIRGYRIELG Mb0104|M.bovis_AF2122/97 FGGSGARMYRTGDLVCWRAD-------GQLEFLGRTDDQVKIRGYRIELG Rv0101|M.tuberculosis_H37Rv FGGSGARMYRTGDLVCWRAD-------GQLEFLGRTDDQVKIRGYRIELG MUL_1722|M.ulcerans_Agy99 ---------------------------------GQADELRSLR------- Mvan_2578|M.vanbaalenii_PYR-1 ---------------------------------EQADELRELR------- MLBr_00484|M.leprae_Br4923 ---------------------------------GQANALHVLK------- MAB_4098c|M.abscessus_ATCC_199 EIQAALADVDGVEQAAVIAREDRPGDKRLVGYFIGTGE----PAELRAAL MAV_3243|M.avium_104 EVQAALAGLDGVEQAAVIAREDRPGDKRLVGYITGTAD----PVGIRIQL TH_3730|M.thermoresistible__bu EVQTALTAVDGVENAVVIAREDRPGDKRLVGYITGTAD----PDQARARL MSMEG_3715|M.smegmatis_MC2_155 EIQCALADLDGVDQAAVVVREDQPGDKRLVGYITGTMD----PAVAREML Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M EVAAALSQLDGVDQAVVIAREDRPGDKRLVGYLVGSVD----AGQARAAL Mb0104|M.bovis_AF2122/97 EVATALAELAGVGQAVVIAREDRPGDKRLVGYATEIAPGAVDPAGLRAQL Rv0101|M.tuberculosis_H37Rv EVATALAELAGVGQAVVIAREDRPGDKRLVGYATEIAPGAVDPAGLRAQL MUL_1722|M.ulcerans_Agy99 ---------QSGADAPVLVTVCRAAAALLGGSASDVQP------------ Mvan_2578|M.vanbaalenii_PYR-1 ---------RSGGERPALETVGRAAGALLGTTAGELEP------------ MLBr_00484|M.leprae_Br4923 ---------QSVANAPVLQTVSRAVGTILGVATTDLPS------------ MAB_4098c|M.abscessus_ATCC_199 AKRLPPYMVPAALVRLEALPLTVNGKLDKRALPAPEYDDAAR-YRAPANA MAV_3243|M.avium_104 AERLPAYMVPAAVVVLDALPLTVNGKLDKRALPAPEYRKRGGEYIAPTNP TH_3730|M.thermoresistible__bu ADRLPAYMVPTAVVVLDALPLTVNGKLDTRALPAPEYQDAEQ-YRAPTHA MSMEG_3715|M.smegmatis_MC2_155 ADHLPPYMVPAAVLRLDTLPVTVNGKLDQRALPVPGYG-NTRIHRPPVTR Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M AQALPAYMVPAAVVVVDSLPLTVNGKLDIRALPAPQYGATGS-YRAPASP Mb0104|M.bovis_AF2122/97 AQRLPGYLVPAAVVVIDALPLTVNGKLDHRALPAPEYGDTNG-YRAPAGP Rv0101|M.tuberculosis_H37Rv AQRLPGYLVPAAVVVIDALPLTVNGKLDHRALPAPEYGDTNG-YRAPAGP MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 VEEAVAGIYAQVLGVERVGTDDSFFDLGGDSISAMRVVAAINTSFDAQLA MAV_3243|M.avium_104 TEETVAGIFARVLGMERVSIDDSFFELGGDSLSAMRVIAEINTAVDGALS TH_3730|M.thermoresistible__bu VEEVLAGIYAEVLGIDKVGVDDSFFDLGGDSISSMQVVARARAAGLTIRP MSMEG_3715|M.smegmatis_MC2_155 TEKVVAGVFGQVLGVEQVGIDDSFFDLGGDSISAMRCVAAINTALDVGVG Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M VEEVLAGIYAQVLGLDRVAVDQSFFDLGGNSILAMRVSSAIEKFLGVDLP Mb0104|M.bovis_AF2122/97 VEKTVAGIFARVLGLERVGVDDSFFELGGDSLAAMRVIAAINTTLNADLP Rv0101|M.tuberculosis_H37Rv VEKTVAGIFARVLGLERVGVDDSFFELGGDSLAAMRVIAAINTTLNADLP MUL_1722|M.ulcerans_Agy99 --------------------DAHFTDLGGDSLSALSFTNLLHEIFDIDVP Mvan_2578|M.vanbaalenii_PYR-1 --------------------SAHFTDLGGDSLSALTFANLLRDIFDVDVP MLBr_00484|M.leprae_Br4923 --------------------NAHFTDLGGDSLSALTFGSLLRELFDIDVP MAB_4098c|M.abscessus_ATCC_199 VRTLFEAPSVRSLSGYLD--GAAGAP-ANGPTYASVHG-PGATEVRASDL MAV_3243|M.avium_104 VRTLFDSQSVRALSQRIT--SGADAENAAGPGFAAVHG-ADAKEVYARDL TH_3730|M.thermoresistible__bu RDIFVERTVARLAQVAVP--TGADAAVDDAGTGPVVAT-PIMRWLYDTRG MSMEG_3715|M.smegmatis_MC2_155 VQDLLQAPQVRLLSRQIEGVGETDTLAAGGATVESVHGSADVTEIRAADL Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M VRLMFEAPTVESLSRQVESPYSSVELAPVELLKQGAGTPLFCLPPGGGLS Mb0104|M.bovis_AF2122/97 VRALLHASSTRGLSQLLGRDARP--TSDPRLVSVHGDNPT---EVHASDL Rv0101|M.tuberculosis_H37Rv VRALLHASSTRGLSQLLGRDARP--TSDPRLVSVHGDNPT---EVHASDL MUL_1722|M.ulcerans_Agy99 VGVIVSPANDLQALADYVEAARKPGSSRPTFASVHGASNEQVTEVHAGDL Mvan_2578|M.vanbaalenii_PYR-1 VGVIVSPATDLQALADYVESARRHGSVRPTFESVHGHSGRPGTEVHARDL MLBr_00484|M.leprae_Br4923 VGVIVSPVNNLVAIADYIERERQ-GTKRPTFIAIHGRDAG---KVHASDL MAB_4098c|M.abscessus_ATCC_199 TLDKFIDEATLQKAPTLPRAEATARTVLLTGATGFLGRYLVLQWLRELEQ MAV_3243|M.avium_104 TLDKFLDATTLSTAPTLPGPSPEVRTVLLTGATGFLGRYLVLEWLEQLEQ TH_3730|M.thermoresistible__bu PIDQFNQTVVLRAPAGVTEAD-------------------VVEILQAVLD MSMEG_3715|M.smegmatis_MC2_155 TLDKFIDDAALSAARNLPRTDAKIRTVLLTGATGFLGRFLVLEWLQRLEP Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M WIYRNLGAYLDCPIIGIQQVPSDQEVEPGSVGDMARRYVDMIQAHHPDGP Mb0104|M.bovis_AF2122/97 TLDRFIDADTLATAVNLPGPSPELRTVLLTGATGFLGRYLVLELLRRLDV Rv0101|M.tuberculosis_H37Rv TLDRFIDADTLATAVNLPGPSPELRTVLLTGATGFLGRYLVLELLRRLDV MUL_1722|M.ulcerans_Agy99 SLDKFIDAATLAEAPRLPAANTQVRTVLLTGATGFLGRYLALEWLERMDL Mvan_2578|M.vanbaalenii_PYR-1 TLDEFVDAATLAHAPTLPGPRAEVRTVLLTGATGFLGRYLALEWLERMAL MLBr_00484|M.leprae_Br4923 TLDKFIDVSTLTAAPVLAQPGTEVRTVLLTGATGFLGRYLALKWLERMDL MAB_4098c|M.abscessus_ATCC_199 VDGTLICLVRAKSDEEARRRLDKTFDSGDPELIRVYEALAADRLQVIAGD MAV_3243|M.avium_104 VDGKLICLVRARSDEEAWGRLEKTFNTGDPELLRHFQELAEEHLQVVAGD TH_3730|M.thermoresistible__bu RH----AMLRLRAADVENLTVPESGAVTARGCLRTVHRLSGDELRSARAE MSMEG_3715|M.smegmatis_MC2_155 VDGKLVCLVRAASDAEARVRLEKVFDCGDPLLLNRFRQLSTNRLQVVAGD Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M YNLLGWSMGGVVAHEIAVELRRRGCEVGRLIVLDAAGEVDSADSVAEPAS Mb0104|M.bovis_AF2122/97 DG-RLICLVRAESDEDARRRLEKTFDSGDPELLRHFKELAADRLEVVAGD Rv0101|M.tuberculosis_H37Rv DG-RLICLVRAESDEDARRRLEKTFDSGDPELLRHFKELAADRLEVVAGD MUL_1722|M.ulcerans_Agy99 VDGKLICLVRAKSDTEARARLEKTFDSGAPELLAHYRALAGDHLEVLAGD Mvan_2578|M.vanbaalenii_PYR-1 VGGKLICLVRAKDDAAARVRLDSTFDSGDPELLRHYRRLAADHLEVIAGD MLBr_00484|M.leprae_Br4923 VEGKVIALVRAKSNEDARARLDKTFDSGDPKLLAHYQELATDHLEVIAGD MAB_4098c|M.abscessus_ATCC_199 KAEPSLGLDQDTWQRLADTVDLIVDSAALVNSVLPYSELFGPNVVGTAEL MAV_3243|M.avium_104 KGQANLGLDEQTWQQLADTVDLIVDSAAVVNGVLPYSELFTPNVGGTAEL TH_3730|M.thermoresistible__bu LDPAAGTMVRALWAPDTRRLALIVHHLAVD----------AVSWRILVED MSMEG_3715|M.smegmatis_MC2_155 KSAAALGLDQETWTELAASVDLVIDSAGFVNGILPYREFFGPNVAGTAEV Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M ESDVLELILVAAGIDIAEHPRPLTYHEAEALLNQRTPVEFSLPPRRIVEI Mb0104|M.bovis_AF2122/97 KSEPDLGLDQPMWRRLAETVDLIVDSAAMVN-AFPYHELFGPNVAGTAEL Rv0101|M.tuberculosis_H37Rv KSEPDLGLDQPMWRRLAETVDLIVDSAAMVN-AFPYHELFGPNVAGTAEL MUL_1722|M.ulcerans_Agy99 KGEADLGLDRQTWQRLADTVDLIVDPAALVNHVLPYSQLFGPNALGTAEL Mvan_2578|M.vanbaalenii_PYR-1 KADADLGLDARTWQRLADTVDLIVDPAALVNHVLPYRQLFAPNVLGTAEL MLBr_00484|M.leprae_Br4923 KGEVDLELDRQTWRRLADTVDLIVDPAALVNHVLPYSELFGPNTLGTAEL MAB_4098c|M.abscessus_ATCC_199 IRFALTTKLKPYTYISTADVGREIEKSVFREDADIRVISATRPSDGSYAN MAV_3243|M.avium_104 IRLALTTRKKPFAYVSTSDVGRQIEPSAFTEDADIRVISATRVIDGSYAN TH_3730|M.thermoresistible__bu INIAWGQR----------HTGQPIDLP---------------------AG MSMEG_3715|M.smegmatis_MC2_155 IRFALTTKLKSYAYVSTADVRQQIDPAAFTEDADIRVISPSRQMDAGYAS Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M M------------------------------------------------- Mb0104|M.bovis_AF2122/97 IRIALTTKLKPFTYVSTADVGAAIEPSAFTEDADIRVISPTRTVDGGWAG Rv0101|M.tuberculosis_H37Rv IRIALTTKLKPFTYVSTADVGAAIEPSAFTEDADIRVISPTRTVDGGWAG MUL_1722|M.ulcerans_Agy99 LRLALTSKIKPYSYTSTIGVADQIPPSAFTEDADIRVISATRAVDDSYAN Mvan_2578|M.vanbaalenii_PYR-1 LRIALTTRMKPFVYVSTIGVGAGIEPARFTEDADIRQISATRRIDDSYAN MLBr_00484|M.leprae_Br4923 IRIALTSKQKPYIYVSTIGVGNQIEPAKFTEDSDIRVISPTRNINNNYAN MAB_4098c|M.abscessus_ATCC_199 GYGNSKWAGEVLLREAHEQVGLPVKVFRSGMIMVDTSYAGQVNASDTVAR MAV_3243|M.avium_104 GYGNSKWAGEVLLREAHDLCGLPVSVFRSDMILADTSYAGQLNVTDIFTR TH_3730|M.thermoresistible__bu GTSFARWS--TLLAEYADTP----------EVVAQAGVWQQVAAX---XW MSMEG_3715|M.smegmatis_MC2_155 GYGNSKWAGEVLLREAHDLCGLPVRVFRCDMILTDTTYSGQLNLPDNFTR Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M -LDNMNANQSMRLKHVPDVFDGDMIVFSAKRDSGGRSLADSWRQYVAGDI Mb0104|M.bovis_AF2122/97 GYGTSKWAGEVLLREANDLCALPVAVFRCGMILADTSYAGQLNMSDWVTR Rv0101|M.tuberculosis_H37Rv GYGTSKWAGEVLLREANDLCALPVAVFRCGMILADTSYAGQLNMSDWVTR MUL_1722|M.ulcerans_Agy99 GYSNSKWAGEVLLREAHVLCGLPVAVFRCDMILADTTWAGQLNVPDMFTR Mvan_2578|M.vanbaalenii_PYR-1 GYGNSKWAGEVLLREAHDLCGLPVSVFRCDMILADTTYAGQLNLPDMFTR MLBr_00484|M.leprae_Br4923 GYGNSKWAGEVLLREAHDLCGLPVTVFRCDMILADTSYAGQLNVPDMFTR MAB_4098c|M.abscessus_ATCC_199 MVLSVVATGVAPYSVYQLDADGNRQRAHFDGLPVEFVAEAITALGGGAAG MAV_3243|M.avium_104 MILSIVATGTAPKSFYRLDADGNRQRSHFDALPVEFVAEAIAKLG---AQ TH_3730|M.thermoresistible__bu PSCSTPTTTSSSTSTWRSTRSTGR-------------------------- MSMEG_3715|M.smegmatis_MC2_155 MVLSVVSTGLAPASFYQLDNTGERQRAHYDALPVGFVAEAISTLS---VG Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M TEYPIDCTHEAMLNIESLQLFADRIAIYLR-------------------- Mb0104|M.bovis_AF2122/97 MVLSLMATGIAPRSFYEPDSEGNRQRAHFDGLPVTFVAEAIAVLGARVAG Rv0101|M.tuberculosis_H37Rv MVLSLMATGIAPRSFYEPDSEGNRQRAHFDGLPVTFVAEAIAVLGARVAG MUL_1722|M.ulcerans_Agy99 MILSLAATGIAPGSFYELAADGARQRAHYDGLPVEFIAEAISTLGAQ--- Mvan_2578|M.vanbaalenii_PYR-1 LIFSLVATGVAPESFYHLATDGTRQRAHYDGLPVEFIAEAISTLGSD--- MLBr_00484|M.leprae_Br4923 MMLSLAATGIAPGSFYELDAESNRQRAHYDGLPVEFIAEAISTLGDQSL- MAB_4098c|M.abscessus_ATCC_199 SFDGSADFETYHVMNPHDDGIGIDEYVDWLIEAGHPIERIDDFGEWVRQF MAV_3243|M.avium_104 VMDG---FETYHVMNPHDDGIGLDEYVDWLIEAGYPIERVDDFGEWLQRF TH_3730|M.thermoresistible__bu ---------------PVRTGCSTRCSSTRTIRS-------------MRRR MSMEG_3715|M.smegmatis_MC2_155 AVDG---FETYHVMNPHDDGVGADQYVDWLIEAGYPIRRIADFAEWLRRF Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M -------------------------------------------------- Mb0104|M.bovis_AF2122/97 --SSLAGFATYHVMNPHDDGIGLDEYVDWLIEAGYPIRRIDDFAEWLQRF Rv0101|M.tuberculosis_H37Rv --SSLAGFATYHVMNPHDDGIGLDEYVDWLIEAGYPIRRIDDFAEWLQRF MUL_1722|M.ulcerans_Agy99 ---SQDGFHTYHVMNPYDDGIGLDEFVDWLNESGCPIQRIADYGDWLQRF Mvan_2578|M.vanbaalenii_PYR-1 ---VASGFRTYHVMNPHDDGIGLDEYVDWLIDAGHPIRRVGDYPTWLQRF MLBr_00484|M.leprae_Br4923 --HDRDGFTTYHVMNPHDDGIGMDEFVDWLIDAGCPIQRINDYDEWLRRF MAB_4098c|M.abscessus_ATCC_199 EARLHALPDHQRQGSVLQMLKILQDHGW--DGQPPEPVRGPMAPADRFHA MAV_3243|M.avium_104 ETGLRGLPERQRQNSVLQMLLLLLRDPK--NLQLAEPARGAFAPTDRFRA TH_3730|M.thermoresistible__bu WPGRKALR------------------------SPISRAANTTTIRCRWSQ MSMEG_3715|M.smegmatis_MC2_155 ETALRSLPERQRQHSVLQILTARHDLAQGADLQAPEPTLGSYGPTDRFRA Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M -------------------------------------------------- Mb0104|M.bovis_AF2122/97 EASLGALPDRQRRHSVLPMLLASNSQRL----QPLKPTRGCSAPTDRFRA Rv0101|M.tuberculosis_H37Rv EASLGALPDRQRRHSVLPMLLASNSQRL----QPLKPTRGCSAPTDRFRA MUL_1722|M.ulcerans_Agy99 ETALRALPDRQRHSSLLPLLHNYR--------QPERPVRGSIAPTDRFRA Mvan_2578|M.vanbaalenii_PYR-1 TVAITALPERQRQASLLPLLHNYQ--------HPETPIRGSIAPTDRFRE MLBr_00484|M.leprae_Br4923 EISLRALPERQRHSSLLPLLHNYQ--------KPEKPLHGSLAPTIRFRT MAB_4098c|M.abscessus_ATCC_199 AVRKAKIGSDHD---IPQVSAPIIAKYASDLQLHGLL----------- MAV_3243|M.avium_104 AVQEAKVGSDND---IPHISAPVIVKYVTDLQLLGLL----------- TH_3730|M.thermoresistible__bu CPGTSSDCASNT---TPRCSTPRMSRHWSAGCGGC------------- MSMEG_3715|M.smegmatis_MC2_155 AVREHRIGGEGD---IPHVTPQIIIKYVADLQRLGLLDAHPTSAPRSA Mflv_2697|M.gilvum_PYR-GCK ------------------------------------------------ MMAR_0099|M.marinum_M ------------------------------------------------ Mb0104|M.bovis_AF2122/97 AVRAAKVGSDKDNPDIPHVSAPTIINYVTNLQLLGLL----------- Rv0101|M.tuberculosis_H37Rv AVRAAKVGSDKDNPDIPHVSAPTIINYVTNLQLLGLL----------- MUL_1722|M.ulcerans_Agy99 AVQEAKIGPDKD---IPHVGAPIIVKYVSDLRLLGLL----------- Mvan_2578|M.vanbaalenii_PYR-1 AVQDAKIGPDKD---IPHVTPQIVIKYVTDLQRLGLL----------- MLBr_00484|M.leprae_Br4923 AVQNANIGQDKD---IPHISPAIIAKYVSDLQLLGLV-----------