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SADPTRTLLSMDLLDDDDHDRLDEWGNRAVLTEPAAEPVSIPVVFAVQVERAPETVALVCRDRSWTYREL DQITNRIAHLLAGNGAGPGEVVGLLVPRSGEAIIGLLAILKTGAAYLPIDPAHPDERIKFMVSDAGPVAV LTTADLGSRFEGLDVSVIEIDDPLIDGQPSSALPTPEPDDLAYMTYTSGTTGVPKAVAVTHHNVTQLVDA VRADLPARPGEVWSQWHSLVFDVSVWEIWGALLHGGRLVVVPESVASSPDDLHELLISEKVSVLCQTPSA AGMLSPERLESTTLIVAGEACPPELVDRWATSGRTMINAYGPTEATIYAAMSGPLTPGSGVAPIGSPVPG AALFVLDKWLRPAPEGVVGELYVAGNGVAPGYAHRSGLTASRFLACPFGGPGSRMYRTGDLVQWGEDGQL QYLGRADEQVKIRGYRIELGEIQAALSRLDGVEQAVVIAREDRPGDKRLVGYIMGTADPVEARNALAERL PAYMVPAAVVVLDALPLTVNGKLDKRALPAPEYRSVGTDYRAPSGPVEKVLADIYAQVLGVDRVGVDESF FDLGGDSILSMQVVSRARAAGVHCRPRDIFVEQTVSGVAAVASLSDGRAGIVDDGIGPVLATPIIHWLQG VPGPVDQFNQTIVLQAPVGVTEDDVVVILQALLDRHATLRLRAESGDASGGWSLLVPDTGTVDARACLRV AESLSDAELVAARSRLNPAAGAQLSAVWVPDSRQLALMIHHLAVDGVSWRILLEDLNIAWAQHHGGQPVQ LPAGGTSFARWAALLDEHARSQDVVATADAWREVTAVPAALPAVMPGLDTYATAKTLSVSLDADTTRELL SEVPAAFHAGVQDILLIAFGLAWNEFLDSNTTSIGIGVEGHGRQEELGRVAGLDIDLSRTVGWFTTKYPV SLSVGGLSWKEIADGSPDLGPIIKSAKEQLRALPDPLTYGLLRYLNPDVDLSGPEPAIGFNYLGRLGAGA ADLTDDLWRINEDSLSSAGVASSVSMPLMYTVDLNAGIVEGGLGEEAGPHLRAGWTWAPSSVTEPQVQRL SQLWFEALAGICAYVRGGGGGLTPSDIAPAQLSQQQIDELHEQHKIVDVLPLTPIQEGLLFHTTFARAAG ALEGDEAGIDFYAVQLDITVTGLVDQLRLRDAVHTVVRRHPNLAARFCTQFGDPVQVILADPVIAWRYLD LRGDDLTPDEEIQHLCAAERAAVCDLADRPTLRAALIRTEGNQHRFVLTFHHVVIDGWSLPILLQEIFAS YFGHRLPAPSSYRSFVSWLADQDLDAARTAWGKVLEGFDTPTLVAPPAPPGARGVESYRVSAETTQALGD LARSQHTTVSTVLQAAWAQLLMVLTGQDDVAFGTAVSGRPAELAGSDSIVGLLINTVPVRARATASTTIA ELLGQLQSAHNDTIEHEHLALNEIHHVAGHEQLFDTLFLYESYPIDTSAFMGVQELAITEFVTREYNHYP LSVMALPGHELGIRVEYDTDKFGLDDIQAVFERFERVLVSMVSDADQRLSSLDVLQTDEHKQLDGWGNRK VLVRGPEPVLSIPEAFAEQVDRAPEAVALTFEGRSTTYGELDEAANRLANLLSVYGAAPGESVALLMPRS DEAIIAILAILKTGASYLPIDPSVPDTRLEFMLSDAVPIAAVTTAELRARFDGSGVSVVQFDDAEDDPTG AIYGHTPLLTPAPDDIAYTIYTSGTTGVPKGVAIAHSNVTQALKFPLTHMPTGPGEVWTQAGSLVFDITV WEIFGALLHGGRLVIIPDSVVRSPDDFRDLLIREKVTVLFQTPSAVGMLSPEGLNNLTLVVAGEACPTEV VDRWAPGRVMINGYGPTETTIYATFGELIAGSGVVPIGVPVPDAALFVLDRWMRPVPPGVVGELYVAGLG VGIGYVKRQALTAARFVACPFGEPGTRMYRTGDLVRWGVSESSVGQLEYLGRADEQVKIRGFRIELGEIQ AALADVDGVEQAAVIAREDRPGDKRLVGYFIGTGEPAELRAALAKRLPPYMVPAALVRLEALPLTVNGKL DKRALPAPEYDDAARYRAPANAVEEAVAGIYAQVLGVERVGTDDSFFDLGGDSISAMRVVAAINTSFDAQ LAVRTLFEAPSVRSLSGYLDGAAGAPANGPTYASVHGPGATEVRASDLTLDKFIDEATLQKAPTLPRAEA TARTVLLTGATGFLGRYLVLQWLRELEQVDGTLICLVRAKSDEEARRRLDKTFDSGDPELIRVYEALAAD RLQVIAGDKAEPSLGLDQDTWQRLADTVDLIVDSAALVNSVLPYSELFGPNVVGTAELIRFALTTKLKPY TYISTADVGREIEKSVFREDADIRVISATRPSDGSYANGYGNSKWAGEVLLREAHEQVGLPVKVFRSGMI MVDTSYAGQVNASDTVARMVLSVVATGVAPYSVYQLDADGNRQRAHFDGLPVEFVAEAITALGGGAAGSF DGSADFETYHVMNPHDDGIGIDEYVDWLIEAGHPIERIDDFGEWVRQFEARLHALPDHQRQGSVLQMLKI LQDHGWDGQPPEPVRGPMAPADRFHAAVRKAKIGSDHDIPQVSAPIIAKYASDLQLHGLL*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. abscessus ATCC 19977 | MAB_4098c | - | - | 100% (2581) | peptide synthetase NRP |
M. abscessus ATCC 19977 | MAB_3317c | - | 0.0 | 65.51% (2589) | peptide synthetase NRP |
M. abscessus ATCC 19977 | MAB_4099c | - | 0.0 | 60.98% (2296) | non-ribosomal peptide synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0104 | nrp | 0.0 | 52.65% (1529) | peptide synthetase |
M. gilvum PYR-GCK | Mflv_2697 | - | 1e-145 | 35.15% (1067) | amino acid adenylation domain-containing protein |
M. tuberculosis H37Rv | Rv0101 | nrp | 0.0 | 52.65% (1529) | peptide synthetase |
M. leprae Br4923 | MLBr_00484 | fadD9 | 1e-172 | 45.99% (798) | putative acyl-CoA synthetase |
M. marinum M | MMAR_0099 | - | 0.0 | 58.41% (2171) | non-ribosomal peptide synthetase |
M. avium 104 | MAV_3243 | - | 0.0 | 68.62% (2591) | linear gramicidin synthetase subunit B |
M. smegmatis MC2 155 | MSMEG_0402 | - | 0.0 | 71.81% (2586) | linear gramicidin synthetase subunit D |
M. thermoresistible (build 8) | TH_3730 | - | 0.0 | 65.33% (2022) | PUTATIVE linear gramicidin synthetase subunit D |
M. ulcerans Agy99 | MUL_1722 | - | 0.0 | 40.76% (1131) | fatty-acid-CoA ligase FadD9 |
M. vanbaalenii PYR-1 | Mvan_2578 | - | 1e-175 | 48.05% (793) | thioester reductase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK --MTAAKTGAIADVMALSPLQQGLYSLTAMS--DGDDPYLIGMSADITGA MMAR_0099|M.marinum_M MTQPTKPVVDIEDVMTLSPLQLGLFALAMASGAASDDPYTVALGIDVHGS Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK LDVSLLHDCAAAVLARHPNLRAGFFQGDLKRPVQVIPEKVEVLWRHVRCD MMAR_0099|M.marinum_M LDVGLLRSCALAMLKRHPNLRARFLGRGLPHPVQVVPSEVQLEWARVEAT Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK GTEVEPLEREERARRFDLGRGPAMRFLLLETGQQRWRFVITAHHIVIDGW MMAR_0099|M.marinum_M AETAGALEAQERNRGFDLEMGPAIRFLLIELPGDRWRFLITAHHIVIGGW Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK SLSLLVSELLALYRAAGNTSALPDAPRPYRDYIGWLAARDQDHARSLWRA MMAR_0099|M.marinum_M SIALFVDELLTLYEADCNIDTLPAQPRPYRDYIGWLERCDVEQGQRQWRE Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK HLADLDGPTLLAPALGAATIG-DGLPGMVELTADPSITEAVVDAARARGV MMAR_0099|M.marinum_M HLAGLAAPTLLAAPLGSSGVQPDSLPKRAELTLDEGATTSLVDGARSRGV Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK TVNSLVQLAWALTLSSLTDRDDITFGVTVSGRPDDLAGVESMIGLFVNTV MMAR_0099|M.marinum_M TVNTLTQLAWALMLSMLTDRRDVVFGVTVSSRPAELARVESMVGLFVNTV Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 --------MSADP-TRTLLSMDLLDDDDHDRLDEWGNRAVLTE------- MSMEG_0402|M.smegmatis_MC2_155 --------MTAEPSTRTLLSFDLLDEDEHDQIEVWGNRAVLTD------- MAV_3243|M.avium_104 --------MTVGA-GRRLLSIDLLDGGEHDRLDEWGNRAILTK------- TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK PLRVRLDPALTAGAQCRALQQDAATLRDHSYLGHAELRALAGVGELFDTL MMAR_0099|M.marinum_M PLRVRLDPKTTVAQQCALIQRDAARLREHAYLSHSQIRALAGMGELFDTL Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 ---------------------------PAAEPVSIPVVFAVQVERAPETV MSMEG_0402|M.smegmatis_MC2_155 ---------------------------PGPTPVTIPALFAEQVVRAPDAV MAV_3243|M.avium_104 ---------------------------PVKAPASIPGMFAAQVARSAEAV TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK LVYENFPPGAVAGAGTLEAAGATFTPVALQSLAHFPVTIAAHLTDGRLTV MMAR_0099|M.marinum_M LVFQNFPSLGLADGKARAVGAARFDSLTVQSPTHFPVCITAELTDARLSL Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 ALVCRD-------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 ALVSGD-------------------------------------------- MAV_3243|M.avium_104 ALSFEG-------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK LVEAKDGALGQITPRALGTRLLATVSRIVEGWDRPLREISISPD------ MMAR_0099|M.marinum_M SIATNANAFGDITESALGDRLVAVLQRLLPMWDRPLRDVSMLLDGQTDGD Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK ----------------------DHPVPVP--------------------- MMAR_0099|M.marinum_M TAVSEHARLDVVGNRAVLAEPLVEPVSVPGLFAAQVASRAEVTALVCGDR Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M SLTYRELDRAANRLAHLLVDQGVGPGDVVGLLLERSVEAVIAILAVLKSG Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M AAYLAIDVNHPDGRIGFMIEDAAPVAVITTAGLAQRLAGYPVAVIDIDDP Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK ------------------------------------------------VS MMAR_0099|M.marinum_M AIATCYPGYGLPFPSADNIAYLIYTSGTTGKPKGVGITHHNITQLFTSVA Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK EAAPTPSP------------------------------------------ MMAR_0099|M.marinum_M ATGFTPAPGQIWTQCHSYAFDYSVWEMWGALLHGGRLVVVPELVTRSAAE Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M LLALLVTEGVGVLSQTPSAFYALQAEDAAQPQLGRQLCLDAVVFGGEALE Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK ------------------------STGVHTRFTETA-------------- MMAR_0099|M.marinum_M PARLGPWLANHGRRPRLINMYGITETTVHASFREIVRHDLGFAVSPVGVP Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M LANLAFFVLDGWLRPVPVGVAGELYVAGAGVGCGYWRRSGLTASRFVACP Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M FGALGARMYRTGDVVRWGPDGQLQYVGRADEQVKIRGYRIELGEVAAALS Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M QLDGVDQAVVIAREDRPGDKRLVGYLVGSVDAGQARAALAQALPAYMVPA Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M AVVVVDSLPLTVNGKLDIRALPAPQYGATGSYRAPASPVEEVLAGIYAQV Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M LGLDRVAVDQSFFDLGGDSLSAMRVVAAINKSLGGDLSVRALFDAPTVAE Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M LAPGIGQGSGQWTPLVAGERPAVVPLSFAQQRLWFIDQLQGPSAVYNMAW Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK SARLG--------------------------------------------- MMAR_0099|M.marinum_M SARLSGELDAAALGAAFADVVGRHESLRTVFRAVAGVAEQLVLGVEQVDV Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M RWQIIDAQGWSSRRLAAALEQQARHCFDLTVEIPLRASLFRVTDDEHVLV Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M VVAHHIAADGWSLRPLVTDLGVAYASRCAGRAPGWAGLAVQYVDYTLWQR Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M TNLGELTDSHSGIAGQLRYWEKALEGMAERLQLPTDRAYPRVADHRGSGV Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M DVQWPAQLQQQVARVAREHHATSFMVIQTALAVLLAKLSGSSDVAVGVPV Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M AGRGDPALDELVGVFVNTVVLRVQVAGDPTFAQLLAQVRTRSLAAFEHQD Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK ----------------------SVALSWD--------------------- MMAR_0099|M.marinum_M VPFEVLVERLNPVRSLTHHPLVQVVLAWQNDMSAELVLDGLDVEFAPVHT Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK ------------------------GG------------------------ MMAR_0099|M.marinum_M QTARMDLVFSLGERFTDTGAPAGIGGGVEFRTDVFDAASIAALIQRLQRV Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M VVAMVADPDRRLSSVDLLDAAEHARLDVVGNRAVLAEPLVEPVSVPGLFA Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 ----------------RSWTYRELDQITNRIAHLLAGNGAGPGEVVGLLV MSMEG_0402|M.smegmatis_MC2_155 ----------------RSWTYRELDEASNRLAHVLAEHGAKPGATVAFLI MAV_3243|M.avium_104 ----------------RSMTYRELDEASNRLAHLLAEQGAAPGECVALLF TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -----------------ALTYRQLDEAADRLAAVLTASGVRTETPVAVRL MMAR_0099|M.marinum_M AQVASRAEVTALVCEDRSLTYRELDRAANRLAHLLVDQGVGPGDVVGLLL Mb0104|M.bovis_AF2122/97 -------------MHRVRLSRSQRNLYNGVRQDNNPALYLIGKSYRFRRL Rv0101|M.tuberculosis_H37Rv -------------MHRVRLSRSQRNLYNGVRQDNNPALYLIGKSYRFRRL MLBr_00484|M.leprae_Br4923 ---------------------MWRQQSISHRKESVMSTITKQEKQLARRV MUL_1722|M.ulcerans_Agy99 -----------------------------------MSPITREER-LERRI Mvan_2578|M.vanbaalenii_PYR-1 -----------------------------------MSTDTREDR-LARRI MAB_4098c|M.abscessus_ATCC_199 PRSGEAIIGLLAILKTGAAYLPIDPAHPDERIKFMVSDAGPVAVLTTADL MSMEG_0402|M.smegmatis_MC2_155 PRSGEAILSILSVLKTGAAYLPVDPAHPDARIGFMMSDAKPVAALTTADL MAV_3243|M.avium_104 SRSDEAIVSILAVLKTGAAYLPIDPALPAARMEFMLGDATPIAAVTTAGL TH_3730|M.thermoresistible__bu --------------------------------------------VTTAEL Mflv_2697|M.gilvum_PYR-GCK RRGADYVVAMFAVLKAGGAIVPLDPAMPADRIEVILRRAGVTVVVDEDTV MMAR_0099|M.marinum_M ERSVEAVIAILAVLKSGAAYLAIDVNHPDGRIGFMIEDAAPVAVITTAGL Mb0104|M.bovis_AF2122/97 ELARFLAALHATVLDNPVQLCVLENSGADYPDLVPRLRFGDIVRVGSADE Rv0101|M.tuberculosis_H37Rv ELARFLAALHATVLDNPVQLCVLENSGADYPDLVPRLRFGDIVRVGSADE MLBr_00484|M.leprae_Br4923 DDLTANDPQFAAAKPDPAVAAALAQPGLRLPQIIQ--------------- MUL_1722|M.ulcerans_Agy99 QDLYANDPQFAAAKPVTAITAAIERPGLPLPQIIE--------------- Mvan_2578|M.vanbaalenii_PYR-1 ADLYATDPQFAAAAPDDAISHAIDQPGTHLPVIVQ--------------- MAB_4098c|M.abscessus_ATCC_199 GSRFEGLDVSVIEIDDPLIDGQ---PSSALPTPEPDDLAYMTYTSGTTGV MSMEG_0402|M.smegmatis_MC2_155 RSRLDQYDLAVIDMADPAIDRR---PSDALSGPRPDDLAYMTYTSGTTGV MAV_3243|M.avium_104 RDRLEGFDLPVIDVDEAAAEIERTQPSSALPGPSPDDIAYMIYTSGTTGT TH_3730|M.thermoresistible__bu GARLHRSGVPVIHIDDPAAPGQAG--ATTGPAPAPDDIAYIIYTSGTTGV Mflv_2697|M.gilvum_PYR-GCK ARATAEPP-----------AQYRP--AETLPG----QAAYVVFTSGTTGE MMAR_0099|M.marinum_M AQRLAGYPVAVIDIDDPAIATCYP--GHGLPFPSADNIAYLIYTSGTTGK Mb0104|M.bovis_AF2122/97 HLQSTWCSGILGKPLVRHTVHTDPNGYVTGLDVHTHHILLDGGATGTIEA Rv0101|M.tuberculosis_H37Rv HLQSTWCSGILGKPLVRHTVHTDPNGYVTGLDVHTHHILLDGGATGTIEA MLBr_00484|M.leprae_Br4923 -------------------------------------TALDGYAERPALG MUL_1722|M.ulcerans_Agy99 -------------------------------------TVMTGYADRPALA Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------TVLDGYAERPALG : . MAB_4098c|M.abscessus_ATCC_199 PKAVAVTHHNVTQLVD----AVRADLPARPGEVWSQWHSLVFDV-SVWEI MSMEG_0402|M.smegmatis_MC2_155 PKAVAVTHHNVTQLVS----ALHADLPSGPGQVWSQWHSLVFDV-SVWEI MAV_3243|M.avium_104 PKGVAVTHRNVTEFLK----TLHPKLPSGPGQVWSQWHSLVFDV-SVWET TH_3730|M.thermoresistible__bu PKGVAVTHRNVAALLS----ALDAELAS--GQVWTQCHSLAFDF-SVWEI Mflv_2697|M.gilvum_PYR-GCK PKGVIGTHRALLAYADDHIGAILRPAADRVGRPLRIAHAWSFTFDAAWQP MMAR_0099|M.marinum_M PKGVGITHHNITQLFTSVAATGFTPAP---GQIWTQCHSYAFDY-SVWEM Mb0104|M.bovis_AF2122/97 DLARYLTTDPAGETPSVGAGLAKLREAHRRETAKVEESRGRLSAVVQREL Rv0101|M.tuberculosis_H37Rv DLARYLTTDPAGETPSVGAGLAKLREAHRRETAKVEESRGRLSAVVQREL MLBr_00484|M.leprae_Br4923 QRVAEFTKDPK-------TGRTSMELLPSFETITYRQLGDRVGALARAWR MUL_1722|M.ulcerans_Agy99 QRSVEFVTDAG-------TGHTTLRLLPHFETISYGELWDRISALADVLS Mvan_2578|M.vanbaalenii_PYR-1 QRAVRFVTDPA-------TGRTTTELLPRFETITYAELSRRIHAVTAALT . . MAB_4098c|M.abscessus_ATCC_199 WGALLHGGRLVVVPESVASSPDDLHELLISEKVSVLCQTPS------AAG MSMEG_0402|M.smegmatis_MC2_155 WGALLHGGRLVVVPESVGSSPDDLHNLLITEKVSVLCQTPS------AAG MAV_3243|M.avium_104 WGALLHGGRLVVVPESVAGSPDDLHDLLVAEGVTVLSQTPS------AVG TH_3730|M.thermoresistible__bu WGPLLYGGRVVIVPDPVVRSPEDLHALLAAEQVGMLSQTPSAFYALQTAD Mflv_2697|M.gilvum_PYR-GCK LAALLDGHSVHIVDDATQRDAEALVDTIARFGVDMIDTTPSMFARLRDVG MMAR_0099|M.marinum_M WGALLHGGRLVVVPELVTRSAAELLALLVTEGVGVLSQTPSAFYALQAED Mb0104|M.bovis_AF2122/97 ADEAYHGGHGHSVSDAPGTAAKGVLHESATICGNAFDAILTLSEAQRVPL Rv0101|M.tuberculosis_H37Rv ADEAYHGGHGHSVSDAPGTAAKGVLHESATICGNAFDAILTLSEAQRVPL MLBr_00484|M.leprae_Br4923 -HDLLHAGYRVCVLGFNSVDYAIIDMALGVIG--------------AVAV MUL_1722|M.ulcerans_Agy99 TEQTVKPSDRVCLLGFNSVDYATIDMTLARLG--------------AVAV Mvan_2578|M.vanbaalenii_PYR-1 ---DVHPGDRVAVLGFTSIDYTTVDMALAMLG--------------AVAV : : MAB_4098c|M.abscessus_ATCC_199 MLSPE---RLESTTLIVAGEACPPELVDRWATS----------------- MSMEG_0402|M.smegmatis_MC2_155 MLSPE---GLESTTLIVAGEACPTELVDRWAP------------------ MAV_3243|M.avium_104 MLSPE---GLDSTALVVAGEACPAEVVDRWAP------------------ TH_3730|M.thermoresistible__bu SLQPEQARQLQLQTVVFGGEALEPQRLSAWMRN----------------- Mflv_2697|M.gilvum_PYR-GCK LLSTVP-----LAVLALGGEAVDPGLWQQIRQEC---------------- MMAR_0099|M.marinum_M AAQPQLGRQLCLDAVVFGGEALEPARLGPWLANH---------------- Mb0104|M.bovis_AF2122/97 NVLVAAAAVAVDASLRQNTETLLVHTVDNRFGDSDLNVATCLVNSVAQTV Rv0101|M.tuberculosis_H37Rv NVLVAAAAVAVDASLRQNTETLLVHTVDNRFGDSDLNVATCLVNSVAQTV MLBr_00484|M.leprae_Br4923 PLQTSAAITQLQSIVTETEPSMIATSVN---------------------- MUL_1722|M.ulcerans_Agy99 PLQTSAAITQLQPIVAETQPTMIAASVD---------------------- Mvan_2578|M.vanbaalenii_PYR-1 PLQTSAPATTVRPIVAETEPVVIASSVD---------------------- : MAB_4098c|M.abscessus_ATCC_199 ---GRTMINAYGPTEATIYAAMSGP--LTPGSGVAPIGSPVPGAALFVLD MSMEG_0402|M.smegmatis_MC2_155 ---GRVMINAYGPTEATIYAAMSEP--LTAGTGVAPIGAPVPGAALFVLD MAV_3243|M.avium_104 ---GRVMINAYGPTEATVYAAMSAP--LTAESGAPPIGSPVPGAALFVLD TH_3730|M.thermoresistible__bu HPERPRLINMYGITETTVHASFREIGAADLDDNTSPIGRPLPHLAFFVLD Mflv_2697|M.gilvum_PYR-GCK ARTGMSAFNCYGPTETTVEAVVAEIGAHER----PTIGRPTAPTRAYVLD MMAR_0099|M.marinum_M GRR-PRLINMYGITETTVHASFREIVRHDLGFAVSPVGVPLANLAFFVLD Mb0104|M.bovis_AF2122/97 RFPPFASVSDVVRTLDRGYVKAVRRRWLREEHYRRMYLAINRTSHVEALT Rv0101|M.tuberculosis_H37Rv RFPPFASVSDVVRTLDRGYVKAVRRRWLREEHYRRMYLAINRTSHVEALT MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 KWLRPAPEGVVGELYVAGNGVAPGYAHRSGLTASRFLACPFGGPGSRMYR MSMEG_0402|M.smegmatis_MC2_155 KWLRPAPEGVVGELYVAGHGVATGYIGRPDLTASRFVACPFGETGERMYR MAV_3243|M.avium_104 KWLRPAPEGVVGELYIAGRGVATGYARRAGLTASRFVACPFGGPGARMYR TH_3730|M.thermoresistible__bu GWLRPVPPGVVGELYVAGAGLATGYVSRSDLTSTRFVACPFGPPGTRMYR Mflv_2697|M.gilvum_PYR-GCK SWLRPVPSGAAGELYLAGGQLTRGYLGRPGETAARFVPDPF-VPGARMYR MMAR_0099|M.marinum_M GWLRPVPVGVAGELYVAGAGVGCGYWRRSGLTASRFVACPFGALGARMYR Mb0104|M.bovis_AF2122/97 LNFIREPCAPGLRPFLSEVPIATDIGPVEGMTVASVLDEEQRTLNLAIWN Rv0101|M.tuberculosis_H37Rv LNFIREPCAPGLRPFLSEVPIATDIGPVEGMTVASVLDEEQRTLNLAIWN MLBr_00484|M.leprae_Br4923 ------------------------------------QLPDTVELILSGQA MUL_1722|M.ulcerans_Agy99 ------------------------------------ALADATELALSGQT Mvan_2578|M.vanbaalenii_PYR-1 ------------------------------------ALTDAVGLALDAPT MAB_4098c|M.abscessus_ATCC_199 TGDLVQWGEDGQLQYLGRADEQVKIRGYRIELGEIQAALSRLDGVEQAVV MSMEG_0402|M.smegmatis_MC2_155 TGDLVRWGSDGQLEYLGRADEQVKIRGYRIELGEIQAALAKLDGVDQAVV MAV_3243|M.avium_104 TGDLVRWGADGQLQYLGRADEQVKIRGYRIELGEIQSALAALDGVDQAAV TH_3730|M.thermoresistible__bu TGDLVRWDTGGELHYIGRADEQVKIRGYRIELGEIQAALARLDGVDQAAV Mflv_2697|M.gilvum_PYR-GCK TGDVVRRAVDGTLAFLGRSDTQVKIRGFRVEPGEVAAVLRTHPAVGQAYV MMAR_0099|M.marinum_M TGDVVRWGPDGQLQYVGRADEQVKIRGYRIELGEVAAALSQLDGVDQAVV Mb0104|M.bovis_AF2122/97 RADLPACKTHPKVAERIAAALESMAAMWDRPIAMIVNDWFGIGPDGTRCQ Rv0101|M.tuberculosis_H37Rv RADLPACKTHPKVAERIAAALESMAAMWDRPIAMIVNDWFGIGPDGTRCQ MLBr_00484|M.leprae_Br4923 PAKLVVFDYHPEVDEQHDAVATARARLADS--SVVVESLTEVLGRGKTLP MUL_1722|M.ulcerans_Agy99 ATRVLVFDHHRQVDAHRAAVESARERLAG---SAVVETLAEAIARGDVPR Mvan_2578|M.vanbaalenii_PYR-1 VTRLVVFDHRAGVDDHRDALISASDRLRAANSPIEVETITDIVARGSKLP : : : MAB_4098c|M.abscessus_ATCC_199 IAREDRPGDKRLVGYIMGTADPVEARNALAERLPAYMVPAAVVVLDALPL MSMEG_0402|M.smegmatis_MC2_155 IAREDRPGDKRLVGYITGTADPAQLRTALAESLPAYMVPTAVVVLDTIPL MAV_3243|M.avium_104 IAREDRPGDKRLVGYITGTADPAELRTQLGKRLPAYMVPAAVVVLESLPL TH_3730|M.thermoresistible__bu IAREDRPGDKRLVGYITGTADPVQARAQLADRLPPYMVPAAIVVLESIPL Mflv_2697|M.gilvum_PYR-GCK AVRPHRDG-HRLTAYVTGEPQLRELRAWLGRRLPRYLMPNAIVAVDRIPL MMAR_0099|M.marinum_M IAREDRPGDKRLVGYLVGSVDAGQARAALAQALPAYMVPAAVVVVDSLPL Mb0104|M.bovis_AF2122/97 GDWPARQPSTPAWFLDSARGVHQFLGRRRFVYPWVAWLVQRGAAPGDVLV Rv0101|M.tuberculosis_H37Rv GDWPARQPSTPAWFLDSARGVHQFLGRRRFVYPWVAWLVQRGAAPGDVLV MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 GAS----------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 TVNGKLDKRALPAPEYRSVGTDYRAPSGPVEKVLADIYAQVLG------- MSMEG_0402|M.smegmatis_MC2_155 TVNGKLDRRALPAPEYRSAANDYRAPSTPAEQILADVYAQVLG------- MAV_3243|M.avium_104 TVNGKLDKRALPAPEYHKRAGQYRAPSNHTEEILADIYAQVLG------- TH_3730|M.thermoresistible__bu TSNNKLDVRALPAPEYRATGAEYRAPGTPLEGLLAGIFAEVLG------- Mflv_2697|M.gilvum_PYR-GCK TAHGKIDEPALVALEPAADG-AATRPQTPTEVELAAVLAEVLG------- MMAR_0099|M.marinum_M TVNGKLDIRALPAPQYGATG-SYRAPASPVEEVLAGIYAQVLG------- Mb0104|M.bovis_AF2122/97 FTDDDTDKTIDLLIACHLAGCGYSVCDTADEISVRTNAITEHGDGILVTV Rv0101|M.tuberculosis_H37Rv FTDDDTDKTIDLLIACHLAGCGYSVCDTADEISVRTNAITEHGDGILVTV MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 --------------VDRVGVDESFFDLGGDSILSMQVVSRARAAGVHCRP MSMEG_0402|M.smegmatis_MC2_155 --------------VERVGVDDSFFDLGGDSILSMQVVARARAAGIQCRP MAV_3243|M.avium_104 --------------VERVGVDDSFFDLGGDSILSMQVVARARAAGVICRP TH_3730|M.thermoresistible__bu --------------VERVGVDDSFFDLGGDSILSMQVVARARAAGVQCRP Mflv_2697|M.gilvum_PYR-GCK --------------VGEIDVTADFLELGLDSIVALSVVQTARRRGVVMRA MMAR_0099|M.marinum_M --------------LDRVAVDQSFFDLGGDSILAIQVVARARAAGVVCRP Mb0104|M.bovis_AF2122/97 VDVAATQLAVVGHDELRKVVDERVTQVTHDALLATKTAYIMPTSGTTGQP Rv0101|M.tuberculosis_H37Rv VDVAATQLAVVGHDELRKVVDERVTQVTHDALLATKTAYIMPTSGTTGQP MLBr_00484|M.leprae_Br4923 -----------------------ATPIPVADDSADPLALLIYTSGSTGAP MUL_1722|M.ulcerans_Agy99 -----------------------AGSAPGTDVSDDSLALLIYTSGSTGAP Mvan_2578|M.vanbaalenii_PYR-1 -------------------------VRAQFSADGDALSLLIYTSGSTGAP * . MAB_4098c|M.abscessus_ATCC_199 RDIFVEQTVSG---VAAVASLSDGRAGIVDDGIGPVLATPIIHWLQGVPG MSMEG_0402|M.smegmatis_MC2_155 RDIFVEQTVAG---VARVA-VAAGESHVVDEGVGPVVATPIMRWLREVDG MAV_3243|M.avium_104 RDVFVEQTVAR---LARVASDGADEEQVVDEGIGPVQATPIMRWLQTVQG TH_3730|M.thermoresistible__bu RDIFVEQTVAR---LASVVKVSGGEPETVDDGTGAVVATPIMRWLRGVDG Mflv_2697|M.gilvum_PYR-GCK KLMLDCATVR---ELAAAIDDAGSGPPSADEGSGPIALLPNAHWLYEFGD MMAR_0099|M.marinum_M RDVFTEQTVAGLATVAAVFDDANDDGGHAEDSVGEVVATPIMLWLQSLDG Mb0104|M.bovis_AF2122/97 KLVRISHGSLAVFCDAISRAYGWG---AHDTVLQCAPLTSDISVEEIFGG Rv0101|M.tuberculosis_H37Rv KLVRISHGSLAVFCDAISRAYGWG---AHDTVLQCAPLTSDISVEEIFGG MLBr_00484|M.leprae_Br4923 KGAMYLQSNVGKMWRRSD-GNWFG-PTAASITLNFMPMSHVMGRGILYGT MUL_1722|M.ulcerans_Agy99 KGAMYPRRNVATFWRKR---TWFEGGYEPSITLNFMPMSHVMGRQILYGT Mvan_2578|M.vanbaalenii_PYR-1 KGAMYPQHLVANSWRRLARSFWGDLGVFPAITLNFMPMSHVMGRGLLYGT : MAB_4098c|M.abscessus_ATCC_199 PVDQFNQTIVLQAPVG----VTEDDVVVILQALLDRHATLRLRAE---SG MSMEG_0402|M.smegmatis_MC2_155 PTGQFNQTVITQAPAG----VTEDDVVVILQALLDRHATLRLRVED--TQ MAV_3243|M.avium_104 PIDDFNQTMVLAAPSG----VTADDVAVVLQALLDRHPMLRLRVE----D TH_3730|M.thermoresistible__bu PTDQFNQTVVLQAPPGTDTAAAEADVVAVLQALIDRHPTLRMRAEGMTAG Mflv_2697|M.gilvum_PYR-GCK P-RRLASTEALRLPRG----ITGPQIRALLQSVVDAHPVLRTRLDR---- MMAR_0099|M.marinum_M PLKEFNQTALLQAPAA----MSYGDVIVSLQAVLDRHAMLRLQVDT---- Mb0104|M.bovis_AF2122/97 AACGARLVRSAAMKTG--------DLAALVDDLVARETTIVDLPTA---- Rv0101|M.tuberculosis_H37Rv AACGARLVRSAAMKTG--------DLAALVDDLVARETTIVDLPTA---- MLBr_00484|M.leprae_Br4923 LGNGG---TAYFAARS--------DLSTLLEDLKLVRPTELNFVPR---- MUL_1722|M.ulcerans_Agy99 LCNGG---TAYFVVKS--------DLSTLFEDLALVRPTELTFVPR---- Mvan_2578|M.vanbaalenii_PYR-1 LDAGG---TAYFAARS--------DLSTFLEDLALVRPTQLSFVPR---- . :: . .: : .. MAB_4098c|M.abscessus_ATCC_199 DASGGWSLLVPDTGTVDARACLRVAESLSDAELVAARSRLNPAAGAQLSA MSMEG_0402|M.smegmatis_MC2_155 EDTDEWSLLVPEAGAVGARECLRTVDALTDDVLVEARNRLDPAAGAMVSA MAV_3243|M.avium_104 DGAGGWNLQAPEPGSVRAADCLQSVDTLSDAVLVAARSRLNPGAGVMVSA TH_3730|M.thermoresistible__bu DGTDDWSLFIPEPGATSAREVMHTVDTLTDEVLIAARSRLNPAAGVMLSA Mflv_2697|M.gilvum_PYR-GCK AAMTLVDGGFDLP--LTEIEVGDEGSAAVARHAAAALEHLDPQRGPLWGA MMAR_0099|M.marinum_M DATGRWLLHVPAPGCVDARKCVRAVTALSDDELVQARSRLDPSAGVMVSA Mb0104|M.bovis_AF2122/97 ----VWQLLCADGDAIDAIGRSRLRQIVIGGEAIRCSAVDKWLESAASQG Rv0101|M.tuberculosis_H37Rv ----VWQLLCADGDAIDAIGRSRLRQIVIGGEAIRCSAVDKWLESAASQG MLBr_00484|M.leprae_Br4923 ----IWETLYDE----------------------SKRAVDRRLANSG--- MUL_1722|M.ulcerans_Agy99 ----VWDMVFDE----------------------FQSEVDRRLVDG---- Mvan_2578|M.vanbaalenii_PYR-1 ----IWDTIHAE----------------------VSQELERRPSDA---- . MAB_4098c|M.abscessus_ATCC_199 VWVP------------------------------------DSRQLALMIH MSMEG_0402|M.smegmatis_MC2_155 VWVR------------------------------------ETSQLVLMIH MAV_3243|M.avium_104 VWAS------------------------------------ETSQLALIIH TH_3730|M.thermoresistible__bu VWAR------------------------------------GSGQLVLMIH Mflv_2697|M.gilvum_PYR-GCK VWLRGSDDADS-----------------------------TSSVLLLTAH MMAR_0099|M.marinum_M LWVT------------------------------------SSAQLALVIH Mb0104|M.bovis_AF2122/97 ISLLSSYGPTEATVVATFLPIVCDQTTMDGALLRLGRPILPNTVFLAFGE Rv0101|M.tuberculosis_H37Rv ISLLSSYGPTEATVVATFLPIVCDQTTMDGALLRLGRPILPNTVFLAFGE MLBr_00484|M.leprae_Br4923 ----------------------------------------------SADR MUL_1722|M.ulcerans_Agy99 -----------------------------------------------ADR Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 HLAVDGVSWRILLEDLNIAWAQHHGGQPVQLPAGGTSFARWAALLDEHAR MSMEG_0402|M.smegmatis_MC2_155 HLAVDGVSWRILLEDLNIAWAQHCTGQSIELPAGGTSFARWSALLAEHAK MAV_3243|M.avium_104 HVAVDGVSWRTLIEDLNIAWAQHHSGQPVALPAGGTSFARWSSLLAEHAL TH_3730|M.thermoresistible__bu HLAVDGVSWRILVEDLNIAWAQHRTGQPIDLPANGTSFARWSALLADHAR Mflv_2697|M.gilvum_PYR-GCK VLAMDPVSWQIVIGELDAGWHALAGGRAPAALGEHTGYRQWSNLLRERAE MMAR_0099|M.marinum_M HLAIDGVSWRILLDDLNSVWEQHRSGEMAALPAGGTSFRRWAALLAEQAY Mb0104|M.bovis_AF2122/97 VVIVGDLVADGYLGIDGDGFGTVTAADGSRRRAFATGDRVTVDAEGFPVF Rv0101|M.tuberculosis_H37Rv VVIVGDLVADGYLGIDGDGFGTVTAADGSRRRAFATGDRVTVDAEGFPVF MLBr_00484|M.leprae_Br4923 AAIKAEVMDEQRQSLLGGRYIAAMTGSAPTSPELKHGVESLLEMHLLEGY MUL_1722|M.ulcerans_Agy99 VALEAQVKAEIRNDVLGGRYTSALTGSAPISDEMKAWVEELLDMHLVEGY Mvan_2578|M.vanbaalenii_PYR-1 ----TEVIADLRRSLLGGRYVTAMTGSAPLSPEMRAFVENLLDVHLIDGY : . : . MAB_4098c|M.abscessus_ATCC_199 SQDVVATADAWREVTAVPAALPAVMPGLDTYATAKTLSVSLDADTTRELL MSMEG_0402|M.smegmatis_MC2_155 TDTVRDLADAWRAVTSVPQALPPVQPDTDTYVTAGQLSASLDVETTRQLL MAV_3243|M.avium_104 TPAVVEQADAWREVVATPAVLPAVQPEVDTYQSAEQLSVSLDVDTTRLLL TH_3730|M.thermoresistible__bu APEVVEHVEAWQRVIAAPSALPAIRPERDTYATAGQLSVSLDADTTRQLL Mflv_2697|M.gilvum_PYR-GCK SS------------------------------------------------ MMAR_0099|M.marinum_M SATAVDHAAAWRQVLATPSVLPAVKPAVDTYATAQRLLVSLDIETTRTLL Mb0104|M.bovis_AF2122/97 SGRKDAVVKISGKRVDIAEVTRRIAEDPAVSDVAVELHSGSLGVWFKSQR Rv0101|M.tuberculosis_H37Rv SGRKDAVVKISGKRVDIAEVTRRIAEDPAVSDVAVELHSGSLGVWFKSQR MLBr_00484|M.leprae_Br4923 GSTEAGMVLFDG-------------------------------------- MUL_1722|M.ulcerans_Agy99 GSTEAGMILIDG-------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 GSTEAGAVFVDG-------------------------------------- MAB_4098c|M.abscessus_ATCC_199 SEVPAAFHAGVQDILLIAFGLAWNEFLDSNTTSIGIGVEGHGRQEELGRV MSMEG_0402|M.smegmatis_MC2_155 GEVPAAFRAGVQDILLVAFGLAWTEFLNRSDTPIGVDVEGHGRYDEL--- MAV_3243|M.avium_104 GEVPAAFHAGVQDILLIAFAMAWTQVVGAG-TPIGIDVEGHGRHEELG-- TH_3730|M.thermoresistible__bu GAVPAAFHAGVQDILLIAFGLAWAEFLGACDSPIGIDVEGHGRAEELA-- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M AAAPAAFHAGVQDILLIAFALAWSEFSSGGGSRIAIDVEGHGRHEELA-- Mb0104|M.bovis_AF2122/97 TREGEQDAAAATRIRLVLVSLGVSSFFVVGVPNIPRKPNGKIDSDNLPRL Rv0101|M.tuberculosis_H37Rv TREGEQDAAAATRIRLVLVSLGVSSFFVVGVPNIPRKPNGKIDSDNLPRL MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 AGLDIDLSRTVGWFTTKYPVSLSVGGLSWKEIADGSPDLGPIIKSAKEQL MSMEG_0402|M.smegmatis_MC2_155 -ASDVDLSRTVGWFTTKYPVALTVENLPWEQVVAGDAALGGIVKAVKEQL MAV_3243|M.avium_104 --PHVDLSRTVGWFTTKYPVALAIDGLDWASVVAGDDALGAAVKAAKEQL TH_3730|M.thermoresistible__bu --AGVDLSRTVGWFTTKYPVALTIPKLSWEQVRTGGDALGAAVKAAKEQL Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M --FGVDLSHTLGWFTTKYPVAVSVGALRWAQVVAGDAALGAVVKDAKEQL Mb0104|M.bovis_AF2122/97 PQWSAAGLNTAETGQRAAGLSQIWSRQLGRAIGPDSSLLGEGIGSLDLIR Rv0101|M.tuberculosis_H37Rv PQWSAAGLNTAETGQRAAGLSQIWSRQLGRAIGPDSSLLGEGIGSLDLIR MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 RALPDPLTYGLLRYLNPDVDLSGPEPAIGFNYLGRLGAGAADLTDDLWRI MSMEG_0402|M.smegmatis_MC2_155 RSLPEGLTYGLLRYLNPEVDLGGSDPTIGFNYLGRLGAGAGELSEELWRI MAV_3243|M.avium_104 RALPDGLTYGLLRYLNPDVDLGGSDPVIGFNYLGRLGA-AADLPGELWRL TH_3730|M.thermoresistible__bu RSVPDGITYGLLRHLNPDVELGGAEPAIGFNYLGRLAAGAGDLPDELWRI Mflv_2697|M.gilvum_PYR-GCK ----DGLQFWLD-------QLGGPDPALGARRVR---------------- MMAR_0099|M.marinum_M RGLPDGLLYGLIRYLNREVELAGAEPTIGFNYLGRLSTRTTAGDDHWQIA Mb0104|M.bovis_AF2122/97 ILPETRRYLGWRLSLLDLIGADTAANLADYAPTPDAPTGEDRFRPLVAAQ Rv0101|M.tuberculosis_H37Rv ILPETRRYLGWRLSLLDLIGADTAANLADYAPTPDAPTGEDRFRPLVAAQ MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 NEDSLSSAGVAS-SVSMPLMYTVDLNAGIVEGGLGEEAGPHLRAGWTWAP MSMEG_0402|M.smegmatis_MC2_155 DQDSLALSDAAS-AVPMPLMHTVELNAGTID----TDNGPSLRASWTWAP MAV_3243|M.avium_104 SPDSLSLSGAAA-AVAMPLMHTVDLNAGTMD----TEDGPHLHANWTWAP TH_3730|M.thermoresistible__bu DPSGLPITEAAS-KIPMPLAHTVEVNAGTLDAG---PDGPVLQATWTWAP Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M RWGSLFTDECASAELPIQLFHTVELDAVTFD----TEAGPQLHAQWTWAT Mb0104|M.bovis_AF2122/97 RPAAIPLSFAQR-------------------------------------- Rv0101|M.tuberculosis_H37Rv RPAAIPLSFAQR-------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 SSVTEPQVQRLSQLWFEALAGICAYVRGGGGGLTPSDIAPAQLSQQQIDE MSMEG_0402|M.smegmatis_MC2_155 SAFDEEQATRLSRLWFEALAGICAHVRGGGGGLTPSDVAPARLTQRQIDE MAV_3243|M.avium_104 SAVDRDQISRLSQLWFEALAGICAHVRAGGGGLTPSDILPARLNQRQIDE TH_3730|M.thermoresistible__bu SLVDEAQIARLSRLWFEALGGVCAHVRSGGGGLTPSDIAPARLTQQQIDE Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M SALDRAQLNRISRLWFEALTGICAHVRAGGGGMTPSDIGLTRLSQHQIDQ Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 LHEQHKIVDVLPLTPIQEGLLFHTTFARAAGALEGDEAGIDFYAVQLDIT MSMEG_0402|M.smegmatis_MC2_155 LSQRYDVTDVLPLTPVQQGLLFHSTFARG--------IGDDVYAVQLDIT MAV_3243|M.avium_104 LSKQHQIADILPLTPLQQGLLFHASFAQD--------PGDDVYAVQLGIT TH_3730|M.thermoresistible__bu LADRHDIADILPLTPVQQGLLFHSAVTRT--------TADDIYAVQLDLT Mflv_2697|M.gilvum_PYR-GCK -----------------------PDTDRA---------GD----VRVTVT MMAR_0099|M.marinum_M LEQRYCVADVLPLTPLQQGLLFHADAARG---------GADLYVVQFDIT Mb0104|M.bovis_AF2122/97 ------------------RLWFLDQLQRP----------APVYNMAVALR Rv0101|M.tuberculosis_H37Rv ------------------RLWFLDQLQRP----------APVYNMAVALR MLBr_00484|M.leprae_Br4923 ------------------------EVQRP----------PVIDYKLVDVP MUL_1722|M.ulcerans_Agy99 ------------------------AIRRP----------AVLDYKLVDVP Mvan_2578|M.vanbaalenii_PYR-1 ------------------------RVQRP----------PVIDYKLVDVA : . : MAB_4098c|M.abscessus_ATCC_199 VTGLVDQLRLRDAVHTVVRRHPNLAAR--FCTQFGDPVQVILADPVIAWR MSMEG_0402|M.smegmatis_MC2_155 ITGVLDQHRLRDAVHTVVARHPNLAAR--FVEQFGEPVQVLTADPMIAWR MAV_3243|M.avium_104 VTGALDSHRLHDAVHTVVNRHPNLAAR--FCPQYGEPVQVVPADPVMAWR TH_3730|M.thermoresistible__bu IAGVVDQHRLRDAVHAVVARHPNLAAR--FCTDHDHPVQIIPTEPVAAWR Mflv_2697|M.gilvum_PYR-GCK VTGADVTARLLAGPHPVLD------------------------------- MMAR_0099|M.marinum_M LSGALDPRRLRTAAQEVLRRHPNLAAQFVWGEPLDEPVQIILNDLVLEWR Mb0104|M.bovis_AF2122/97 LRGYLDTEALGAAVADVVGRHESLRTVFPAVDGVPRQLVIEARRADLGCD Rv0101|M.tuberculosis_H37Rv LRGYLDTEALGAAVADVVGRHESLRTVFPAVDGVPRQLVIEARRADLGCD MLBr_00484|M.leprae_Br4923 DLGYFSTDQPYPRGELLLKTQNMFPGYYKRPE------------------ MUL_1722|M.ulcerans_Agy99 DLGYFLTDRPHPRGELLVKTDSLFPGYYQRAE------------------ Mvan_2578|M.vanbaalenii_PYR-1 DLGYFSTDRPHPRGELLVKSETLFPGYYKRPD------------------ * :: MAB_4098c|M.abscessus_ATCC_199 YLDLRGD---DLTPDEEIQHLCAAERAAVCDLADRPTLRAALIRTEGNQH MSMEG_0402|M.smegmatis_MC2_155 YLDLRGD---DLTPDHEIEQLCAAERSAVCDLLERPTFRAALIRTSGNQH MAV_3243|M.avium_104 YIQLGPE---DVDPEQKVEELCAAERAAVSDLANRPAFRAALIRTADNRH TH_3730|M.thermoresistible__bu YLDLRGD---DQNPEHEVQQLCAAERAAVRDLTERPTFRAALIRTGATEH Mflv_2697|M.gilvum_PYR-GCK --------------------------VLVAALG----------------- MMAR_0099|M.marinum_M TVEFDPAGDPDAHVEQHIDEVCADERVAVADLGGGSPFRIALIRTAPCEH Mb0104|M.bovis_AF2122/97 IVDATAWP------ADRLQRAIEEAARHSFDLATEIPLRTWLFRIADDEH Rv0101|M.tuberculosis_H37Rv IVDATAWP------ADRLQRAIEEAARHSFDLATEIPLRTWLFRIADDEH MLBr_00484|M.leprae_Br4923 -VTATVFD------SDGYYQTGDIVAEVGPDRLVYVDRRNNVLKLAQGQF MUL_1722|M.ulcerans_Agy99 -VTADVFD------ADGFYRTGDIMAEVGPEQFVYLDRRNNVLKLSQGEF Mvan_2578|M.vanbaalenii_PYR-1 -VTAEMFD------EDGYYRTGDIVAETGADQLTYLDRRNNVLKLSQGEF MAB_4098c|M.abscessus_ATCC_199 RFVLTFHHVVIDGWSLPILLQEIFASYFGHRLPAPSSYRSFVSWLADQDL MSMEG_0402|M.smegmatis_MC2_155 RFVLTFHHIVIDGWSLPILLQEIFAGYFGHRLPAAAPYRNFVNWLATQDA MAV_3243|M.avium_104 RFVLTNHHIVMDGWSLPILLREILAIYYGDQLPAPATYRSYLTWLAGQDR TH_3730|M.thermoresistible__bu RFVLTVHHIVIDGWSLPILLQEIFAGYFGQRLPAPARFRDFVTWLAAQDR Mflv_2697|M.gilvum_PYR-GCK --------------------------------------RTITEWRGRRNQ MMAR_0099|M.marinum_M RLVLTAHHIVCDGWSMPIVMQEILAAYAGQPLAAPGSYRNFLTWLAERDK Mb0104|M.bovis_AF2122/97 VLVAVAHHIAADGWSVAPLTADLSAAYASRCAGRAPDWAPLPVQYVDYTL Rv0101|M.tuberculosis_H37Rv VLVAVAHHIAADGWSVAPLTADLSAAYASRCAGRAPDWAPLPVQYVDYTL MLBr_00484|M.leprae_Br4923 VTVAKLEAAFSN-------------------------------------- MUL_1722|M.ulcerans_Agy99 VTVSKLEAVFGD-------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 VTVSRLEAVFGN-------------------------------------- MAB_4098c|M.abscessus_ATCC_199 DAARTAWGKVLEGFDTPTLVAPPAPP-------------------GARGV MSMEG_0402|M.smegmatis_MC2_155 TAAKAAWREVLDGFETPTLVAPPGVP-------------------GPRGI MAV_3243|M.avium_104 SAAQAAWRQVLDGFDTPTLVGPAGRMR-----------------LGRRAV TH_3730|M.thermoresistible__bu DAARAAWRELLDGFDTPTLIAPPGQA-------------------GPRGS Mflv_2697|M.gilvum_PYR-GCK PTP-------------PPLVALETHG------------------------ MMAR_0099|M.marinum_M SAARTAWRELFADFRHPTLVGLPDHLG-----------------LGSRGV Mb0104|M.bovis_AF2122/97 WQREILGDLDDSDSPIAAQLAYWENALAGMPERLRLPTARPYPPVADQRG Rv0101|M.tuberculosis_H37Rv WQREILGDLDDSDSPIAAQLAYWENALAGMPERLRLPTARPYPPVADQRG MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 ESYRVSAETTQALGDLARSQHTTVSTVLQAAWAQLLMVLTGQDDVAFGTA MSMEG_0402|M.smegmatis_MC2_155 ESYRVSAETTRALGELARSQHTTINTVLQAAWTQLLMRMTGQRDVAFGTA MAV_3243|M.avium_104 ESYRLSADTTRALGELARACHTTVNTVLQAGWAQLLMRLTGQHDVAFGTA TH_3730|M.thermoresistible__bu ASYRIDTETTAAIGELARTQRTTVNTVLQAAWAHLLMAMTGQRDVVFGTA Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------RAALAEA MMAR_0099|M.marinum_M ESYLLPIGITEALTELARSCRVTVNIVLQAAFAQLLSWLTGQHDVAFGTT Mb0104|M.bovis_AF2122/97 ASLVVDWPASVQQQVRRIARQHNATSFMVVAAGLAVLLSKLSGSPDVAVG Rv0101|M.tuberculosis_H37Rv ASLVVDWPASVQQQVRRIARQHNATSFMVVAAGLAVLLSKLSGSPDVAVG MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 VSGRPAELAGSDSIVGLLINTVPVRARATASTTIAELLGQLQS------- MSMEG_0402|M.smegmatis_MC2_155 VSGRPADLAGAESMVGLLINTVPIRAKVSADTTVGDLLRQLQS------- MAV_3243|M.avium_104 VSGRPADLAGAESMVGLLINTVPVRANTHAETTVADLLDQLQQ------- TH_3730|M.thermoresistible__bu VSGRPADLPGADRIVGLLINTIPVRARIGADTTVADLLAQLQH------- Mflv_2697|M.gilvum_PYR-GCK DTADTADTADTSDTVGLLSAIYPLRLHEDSPGATTELIAGVPAGG----- MMAR_0099|M.marinum_M VSGRPAEVAGVHSMVGLFINTVPTRARMASTTTTRELLDQLQS------- Mb0104|M.bovis_AF2122/97 FPIAGRSDPALDNLVGFFVNTLVLRVNLAGDPSFAELLGQVRARSLAAYE Rv0101|M.tuberculosis_H37Rv FPIAGRSDPALDNLVGFFVNTLVLRVNLAGDPSFAELLGQVRARSLAAYE MLBr_00484|M.leprae_Br4923 -------------------SPLVRQIYIYGNSAHPYLLAVVVP------- MUL_1722|M.ulcerans_Agy99 -------------------SPLVRQIYIYGNSARAYLLAVIVP------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------SPLVRQIYVYGNSARPYLLAVVVP------- : . : *: : MAB_4098c|M.abscessus_ATCC_199 ----AHNDTIEHEHLALNEIHHVAGHEQLFDTLFLYESYPIDTSAFMGVQ MSMEG_0402|M.smegmatis_MC2_155 ----HHNDTLEHEHLALNDIHHVSGHEQLFDTLFLYESYPIDTSAFMGVQ MAV_3243|M.avium_104 ----HHNDTLEHEHLALSEIHRVTGHDALFDTLFLYENYPIDTSVPLGFH TH_3730|M.thermoresistible__bu ----AHNDTLEHEHLALTEIHHLAGHDQLFDTLFLYESYPIDTGAFSGAQ Mflv_2697|M.gilvum_PYR-GCK ----IDYGLLRYLRPDTS-------------------------------- MMAR_0099|M.marinum_M ----VHYETLEHHHLALSDIHRVSGHDQLFDTLFVYENYPIDKTAAQGTG Mb0104|M.bovis_AF2122/97 NQDVPFEVLVDRLKPTRALTHHPLIQVMLAWQDNPVGQLNLGDLQATPMP Rv0101|M.tuberculosis_H37Rv NQDVPFEVLVDRLKPTRALTHHPLIQVMLAWQDNPVGQLNLGDLQATPMP MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 ELAITEFVTREYNHYPLSVMALPGHELGIRVEYDTDKFGLDDIQAVFERF MSMEG_0402|M.smegmatis_MC2_155 ELAVTEFNNREYNHYPLSVMALPGHELGLRVEYDTSVFDVSEIETLIDRF MAV_3243|M.avium_104 ELAITDVTNREYNHYPLSVMALPGRELGLRVEFDTDVFDAAGIEKLTERF TH_3730|M.thermoresistible__bu ELAVTGFTNREFNHYPLSVMALPGHELGLRIEYDTEVFDTAAIDALADRF Mflv_2697|M.gilvum_PYR-GCK ----------------EVLKAHPEPQILLNYLGRTDLVPSGAIVADRLLL MMAR_0099|M.marinum_M ELAISGIGCREYSHYPLVVQAMPGDQLGLRVEFRTDVFDAASIAALIQRL Mb0104|M.bovis_AF2122/97 IDTRTARMDLVFSLAERFSEGSEPAGIGGAVEYRTDVFEAQAIDVLIERL Rv0101|M.tuberculosis_H37Rv IDTRTARMDLVFSLAERFSEGSEPAGIGGAVEYRTDVFEAQAIDVLIERL MLBr_00484|M.leprae_Br4923 ---------------------------------TEDALATNDIEVLKPLI MUL_1722|M.ulcerans_Agy99 ---------------------------------TQEALDAVPVEELKARL Mvan_2578|M.vanbaalenii_PYR-1 ---------------------------------TEAALAG---ADAKAAV . . MAB_4098c|M.abscessus_ATCC_199 ERVLVSMVSDADQRLSSLDVLQTDEHKQLDGWGNRKVLVRGPEPVLSIPE MSMEG_0402|M.smegmatis_MC2_155 QRLLEAMIDDPARRLSSMDVVDDDERTQLDEWANRAVLTQPVDSPQSIPE MAV_3243|M.avium_104 QRVLSEMTADPTRRLTSLEVMDEAEHELLDAWGNRPVLSQPATG-TSIPA TH_3730|M.thermoresistible__bu RRVLESMVGDPARRLSAIEVLDAAEREQLDAWSNRAVLAD-SPALESIPE Mflv_2697|M.gilvum_PYR-GCK S------------GLSTVPEPNAAVRHELTVV------------------ MMAR_0099|M.marinum_M QRVVVAMVADPDRRLSSVDLLDAAEHARLDVVGNRAVLAEPLVEPVSVPG Mb0104|M.bovis_AF2122/97 RKVLVAVAAAPERTVSSIDALDGTERARLDEWGNRAVLTAPAPTPVSIPQ Rv0101|M.tuberculosis_H37Rv RKVLVAVAAAPERTVSSIDALDGTERARLDEWGNRAVLTAPAPTPVSIPQ MLBr_00484|M.leprae_Br4923 IDSLQKVAKEAD-------------------------------------- MUL_1722|M.ulcerans_Agy99 GDSLQEVAKAAG-------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 AESLQDVAKATG-------------------------------------- MAB_4098c|M.abscessus_ATCC_199 AFAEQVDRAPEAVALTFEGRSTTYGELDEAANRLANLLSVYGAAPGESVA MSMEG_0402|M.smegmatis_MC2_155 VFARQVERDPEAPAVTFEGESLNYGELDEAANQLANLLAVYGAAPGKSVA MAV_3243|M.avium_104 LFAAQVARTPDAAALTFQGRSMSYRELDEASNRLAHLLIEEGAGPGECVA TH_3730|M.thermoresistible__bu VFARQVARDPGAVAVTFEGRSMTYGELDDAATELANLLAVYGAGPGESVA Mflv_2697|M.gilvum_PYR-GCK ---AAVVAHGDEPALVAQWRVLPEILSDTDVEEMQTIWQDT--------- MMAR_0099|M.marinum_M LFAAQVASRAEVTALVCGDRSLTYRELDRAANRLAHLLVDQGVGPGDVVG Mb0104|M.bovis_AF2122/97 MLAAQVARIPEAEAVCCGDASMTYRELDEASNRLAHRLAGCGAGPGECVA Rv0101|M.tuberculosis_H37Rv MLAAQVARIPEAEAVCCGDASMTYRELDEASNRLAHRLAGCGAGPGECVA MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 LLMPRSDEAIIAILAILKTGASYLPIDPSVPDTRLEFMLSDAVPIAAVTT MSMEG_0402|M.smegmatis_MC2_155 LMVPRSADAIVAILAVLKTGAAYLPIDPSVPAARLEFMLGDAKPVAAVTT MAV_3243|M.avium_104 LLFSRSAEAIVSILAVLKTGAAYLPIDPALPAARIEFLLGDAEPVAVVTT TH_3730|M.thermoresistible__bu LLMPRSADAIVAILAVLKTGAAYLPIDPAVPAARLEFMLSDAEPIVALTT Mflv_2697|M.gilvum_PYR-GCK ------------LREVL--------------------------------- MMAR_0099|M.marinum_M LLLERSVEAVIAILAVLKSGAAYLAIDVNHPDGRIGFMIEDAAPVAVITT Mb0104|M.bovis_AF2122/97 LLFERCAPAVVAMVAVLKTGAAYLPIDPANPPPRVAFMLGDAVPVAAVTT Rv0101|M.tuberculosis_H37Rv LLFERCAPAVVAMVAVLKTGAAYLPIDPANPPPRVAFMLGDAVPVAAVTT MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 AELRARFDGSGVS-----VVQFDDAEDDPTGAIYGHTPLLTPAPDDIAYT MSMEG_0402|M.smegmatis_MC2_155 GDLRSRFDGFDLQ-----VVEVD----DPAVEIYPSTTLLTPSPDDIAYM MAV_3243|M.avium_104 AALRSRLDGCKPS-----VVDVD----DPALDGQPSAALPVPSSDNIAYL TH_3730|M.thermoresistible__bu VELGTRFNGTGVP-----IIEVD----DPAPPMYPSSTLLPPAPDDIAYL Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M AGLAQRLAGYPVA-----VIDIDDP---AIATCYPGHGLPFPSADNIAYL Mb0104|M.bovis_AF2122/97 AGLRSRLAGHDLPIIDVVDA----------LAAYPGTPPPMPAAVNLAYI Rv0101|M.tuberculosis_H37Rv AGLRSRLAGHDLPIIDVVDA----------LAAYPGTPPPMPAAVNLAYI MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 IYTSGTTGVPKGVAIAHSNVTQALKFPLTH-MPTGPGEVWTQAGSLVFDI MSMEG_0402|M.smegmatis_MC2_155 IYTSGTTGVPKGVAITHGNVTQVLDTLPAE-LPAGPGAVWSQWHSLVFDV MAV_3243|M.avium_104 IYTSGTTGVPKGVAVSHDNVAQLVESLHAD-LPEG--GVWAQWHSLVFDV TH_3730|M.thermoresistible__bu IYTSGTTGVPKGVAITHANVTRVLHTLPAD-LPAGPGKVWSQWHSLVFDV Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M IYTSGTTGKPKGVGITHHNITQLFTSVAATGFTPAPGQIWTQCHSYAFDL Mb0104|M.bovis_AF2122/97 LYTSGTTGEPKGVGITHRNVTRLFASLPAR---LSAAQVWSQCHSYGFDA Rv0101|M.tuberculosis_H37Rv LYTSGTTGEPKGVGITHRNVTRLFASLPAR---LSAAQVWSQCHSYGFDA MLBr_00484|M.leprae_Br4923 ------------------------------------LQSYEVPRDLIVET MUL_1722|M.ulcerans_Agy99 ------------------------------------LQSYEIPRDFIIET Mvan_2578|M.vanbaalenii_PYR-1 ------------------------------------LQSYEIPRDFLLET MAB_4098c|M.abscessus_ATCC_199 TVWEIFGALLHGGRLVIIPDSVVRSPDDFRDLLIREKVTVLFQTPSAVGM MSMEG_0402|M.smegmatis_MC2_155 SVWEIWGALLHGGRLVIVPESIAGSPDDLHALLVSEGVNVLYQTPSAVRM MAV_3243|M.avium_104 SVHEIWGALLHGGRLVVVPESVAASPDELHDLLVAEGVTVLSQTPSAVGM TH_3730|M.thermoresistible__bu SVWEIWGALLHGGRLVIVPESITGSPDDLHDLLVAEHVDVVYQTPSAAGM Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M SVFEMWGALLHGGRLVVVPESVTGSPADLHALLVAEQVDVLAQTPSAVAM Mb0104|M.bovis_AF2122/97 SAWEIWGALLGGGRLVIVPESVAASPNDFHGLLVAEHVSVLTQTPAAVAM Rv0101|M.tuberculosis_H37Rv SAWEIWGALLGGGRLVIVPESVAASPNDFHGLLVAEHVSVLTQTPAAVAM MLBr_00484|M.leprae_Br4923 TPFSLENGLLTGIRKLAWPK------------------------------ MUL_1722|M.ulcerans_Agy99 TPWTLQNGLLTGIRKLARPQ------------------------------ Mvan_2578|M.vanbaalenii_PYR-1 TPFTLENGLLTGIRKLARPR------------------------------ MAB_4098c|M.abscessus_ATCC_199 LSPEGLNNLTLVVAGEACPTEVVDRWAPGRVMINGYGPTETTIYATFG-E MSMEG_0402|M.smegmatis_MC2_155 MSPEGLEGTALVVAGEACPTEVVDRWAVDRVMINAYGPTESTIYAAISAP MAV_3243|M.avium_104 LSPEGLDSTALVVAGEACPVEIVDRWAPGRVMINAYGPTEATVYAAMSTP TH_3730|M.thermoresistible__bu LSQRGLDSTALVVAGEACPTDLVDRWAPGRVMINAYGPTETTMCVAISAP Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M LSTQGLESTTLVVGGEACPAEVVDNWAPGRMMVNQYGPSETTMYVSMSAP Mb0104|M.bovis_AF2122/97 LPTQGLESVALVVAGEACPAALVDRWAPGRVMLNAYGPTETTICAAISAP Rv0101|M.tuberculosis_H37Rv LPTQGLESVALVVAGEACPAALVDRWAPGRVMLNAYGPTETTICAAISAP MLBr_00484|M.leprae_Br4923 -------------------------------LKQHYGARLEQLYADLVE- MUL_1722|M.ulcerans_Agy99 -------------------------------LKKHYGELLEQIYTDLAH- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------LRERYGEQLEALYTMLSE- MAB_4098c|M.abscessus_ATCC_199 LIAGSGVVPIGVPVPDAALFVLDRWMRPVPPGVVGELYVAGLGVGIGYVK MSMEG_0402|M.smegmatis_MC2_155 LSPGSDVVPIGSPVPKGATFVLDEWLRPVPPGVVGELYLAGRGVGVGYVG MAV_3243|M.avium_104 LQPGTGSAPIGSPVPRAALFVLDRWLRPAPPGVVGELYIAGHGVATGYAR TH_3730|M.thermoresistible__bu LTPGSGAVPIGTPVPRAALFVLDSWMRPVPAGVIGELYVAGDGVAVGYVG Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M LVPGSGPAPIGVPVPRAALFVLDGWLRPVPAGVAGELYVAGAGVGCGYWR Mb0104|M.bovis_AF2122/97 LRPGSGMPPIGVPVSGAALFVLDSWLRPVPAGVAGELYIAGAGVGVGYWR Rv0101|M.tuberculosis_H37Rv LRPGSGMPPIGVPVSGAALFVLDSWLRPVPAGVAGELYIAGAGVGVGYWR MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 RQALTAARFVACPFGEPGTRMYRTGDLVRWGVSESSVGQLEYLGRADEQV MSMEG_0402|M.smegmatis_MC2_155 RSGLTGTRFVACPFGEPGARMYRTGDLVRWGDD----GQLQYLGRADEQV MAV_3243|M.avium_104 RSGLTASRFVACPFGGPGARMYRTGDLVRWNQD----GQLEYLGRADEQV TH_3730|M.thermoresistible__bu RSELTASRFVACPFGPPGSRMYRTGDLVRWGAD----GQLQYLGRADEQV Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M RSGLTASRFVACPFGALGARMYRTGDVVRWGPD----GQLQYVGRADEQV Mb0104|M.bovis_AF2122/97 RAGLTASRFVACPFGGSGARMYRTGDLVCWRAD----GQLEFLGRTDDQV Rv0101|M.tuberculosis_H37Rv RAGLTASRFVACPFGGSGARMYRTGDLVCWRAD----GQLEFLGRTDDQV MLBr_00484|M.leprae_Br4923 -------------------------------------------GQANALH MUL_1722|M.ulcerans_Agy99 -------------------------------------------GQADELR Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------EQADELR MAB_4098c|M.abscessus_ATCC_199 KIRGFRIELGEIQAALADVDGVEQAAVIAREDRPGDKRLVGYFIGTGE-- MSMEG_0402|M.smegmatis_MC2_155 KIRGYRIELGEIQAALSDVDGVDQAVVIAREDRPGDKRLVGYITGTAD-- MAV_3243|M.avium_104 KLRGYRIELGEVQAALAGLDGVEQAAVIAREDRPGDKRLVGYITGTAD-- TH_3730|M.thermoresistible__bu KIRGYRIELGEVQTALTAVDGVENAVVIAREDRPGDKRLVGYITGTAD-- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M KIRGYRIELGEVAAALSQLDGVDQAVVIAREDRPGDKRLVGYLVGSVD-- Mb0104|M.bovis_AF2122/97 KIRGYRIELGEVATALAELAGVGQAVVIAREDRPGDKRLVGYATEIAPGA Rv0101|M.tuberculosis_H37Rv KIRGYRIELGEVATALAELAGVGQAVVIAREDRPGDKRLVGYATEIAPGA MLBr_00484|M.leprae_Br4923 VLK----------------QSVANAPVLQTVSRAVGTILGVATTDLPS-- MUL_1722|M.ulcerans_Agy99 SLR----------------QSGADAPVLVTVCRAAAALLGGSASDVQP-- Mvan_2578|M.vanbaalenii_PYR-1 ELR----------------RSGGERPALETVGRAAGALLGTTAGELEP-- MAB_4098c|M.abscessus_ATCC_199 --PAELRAALAKRLPPYMVPAALVRLEALPLTVNGKLDKRALPAPEYDD- MSMEG_0402|M.smegmatis_MC2_155 --PAAARSELTNRLPAYMVPAAVVTLETLPLTVNGKLDRRALPAPEYQS- MAV_3243|M.avium_104 --PVGIRIQLAERLPAYMVPAAVVVLDALPLTVNGKLDKRALPAPEYRKR TH_3730|M.thermoresistible__bu --PDQARARLADRLPAYMVPTAVVVLDALPLTVNGKLDTRALPAPEYQD- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M --AGQARAALAQALPAYMVPAAVVVVDSLPLTVNGKLDIRALPAPQYGA- Mb0104|M.bovis_AF2122/97 VDPAGLRAQLAQRLPGYLVPAAVVVIDALPLTVNGKLDHRALPAPEYGD- Rv0101|M.tuberculosis_H37Rv VDPAGLRAQLAQRLPGYLVPAAVVVIDALPLTVNGKLDHRALPAPEYGD- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 AARYRAPANAVEEAVAGIYAQVLGVERVGTDDSFFDLGGDSISAMRVVAA MSMEG_0402|M.smegmatis_MC2_155 AQRYRAPETETEKTLAGIFAHVLGVERIGLDDSFFDLGGDSISAMRVTAA MAV_3243|M.avium_104 GGEYIAPTNPTEETVAGIFARVLGMERVSIDDSFFELGGDSLSAMRVIAE TH_3730|M.thermoresistible__bu AEQYRAPTHAVEEVLAGIYAEVLGIDKVGVDDSFFDLGGDSISSMQVVAR Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M TGSYRAPASPVEEVLAGIYAQVLGLDRVAVDQSFFDLGGNSILAMRVSSA Mb0104|M.bovis_AF2122/97 TNGYRAPAGPVEKTVAGIFARVLGLERVGVDDSFFELGGDSLAAMRVIAA Rv0101|M.tuberculosis_H37Rv TNGYRAPAGPVEKTVAGIFARVLGLERVGVDDSFFELGGDSLAAMRVIAA MLBr_00484|M.leprae_Br4923 ------------------------------NAHFTDLGGDSLSALTFGSL MUL_1722|M.ulcerans_Agy99 ------------------------------DAHFTDLGGDSLSALSFTNL Mvan_2578|M.vanbaalenii_PYR-1 ------------------------------SAHFTDLGGDSLSALTFANL MAB_4098c|M.abscessus_ATCC_199 INTSFDAQLAVRTLFEAPSVRSLSGYLDGAAGAP-ANGPTYASVHGP--- MSMEG_0402|M.smegmatis_MC2_155 VNTALDADLSVRTLFEAPTVAKLSLHVEHDAGER-TDRVSFAAVHGS--- MAV_3243|M.avium_104 INTAVDGALSVRTLFDSQSVRALSQRITSGADAENAAGPGFAAVHGA--- TH_3730|M.thermoresistible__bu ARAAGLTIRPRDIFVERTVARLAQVAVPTGADAAVDDAGTGPVVATP--- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M IEKFLGVDLPVRLMFEAPTVESLSRQVESPYSSVELAPVELLKQGAG--- Mb0104|M.bovis_AF2122/97 INTTLNADLPVRALLHASSTRGLSQLLGRDARP--TSDPRLVSVHGD--- Rv0101|M.tuberculosis_H37Rv INTTLNADLPVRALLHASSTRGLSQLLGRDARP--TSDPRLVSVHGD--- MLBr_00484|M.leprae_Br4923 LRELFDIDVPVGVIVSPVNNLVAIADYIERERQ-GTKRPTFIAIHGR--- MUL_1722|M.ulcerans_Agy99 LHEIFDIDVPVGVIVSPANDLQALADYVEAARKPGSSRPTFASVHGASNE Mvan_2578|M.vanbaalenii_PYR-1 LRDIFDVDVPVGVIVSPATDLQALADYVESARRHGSVRPTFESVHGHSGR MAB_4098c|M.abscessus_ATCC_199 GATEVRASDLTLDKFIDEATLQKAPTLPRAEATARTVLLTGATGFLGRYL MSMEG_0402|M.smegmatis_MC2_155 DVTEVHARDLTLDKFIDAPTLRTATTLPRPDGAVQTVLLTGATGFLGRYL MAV_3243|M.avium_104 DAKEVYARDLTLDKFLDATTLSTAPTLPGPSPEVRTVLLTGATGFLGRYL TH_3730|M.thermoresistible__bu IMRWLYDTRGPIDQFNQTVVLRAPAGVT--EADVVEILQA---------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M TPLFCLPPGGGLSWIYRNLGAYLDCPIIG--------------------- Mb0104|M.bovis_AF2122/97 NPTEVHASDLTLDRFIDADTLATAVNLPGPSPELRTVLLTGATGFLGRYL Rv0101|M.tuberculosis_H37Rv NPTEVHASDLTLDRFIDADTLATAVNLPGPSPELRTVLLTGATGFLGRYL MLBr_00484|M.leprae_Br4923 DAGKVHASDLTLDKFIDVSTLTAAPVLAQPGTEVRTVLLTGATGFLGRYL MUL_1722|M.ulcerans_Agy99 QVTEVHAGDLSLDKFIDAATLAEAPRLPAANTQVRTVLLTGATGFLGRYL Mvan_2578|M.vanbaalenii_PYR-1 PGTEVHARDLTLDEFVDAATLAHAPTLPGPRAEVRTVLLTGATGFLGRYL MAB_4098c|M.abscessus_ATCC_199 VLQWLRELEQVDGTLICLVRAKSDEEARRRLDKTFDSGDPELIRVYEALA MSMEG_0402|M.smegmatis_MC2_155 LLEWLRQLRRVDDKVICLVRGKSDEDARRRLEATFDT-DPLLRKHFNELA MAV_3243|M.avium_104 VLEWLEQLEQVDGKLICLVRARSDEEAWGRLEKTFNTGDPELLRHFQELA TH_3730|M.thermoresistible__bu VLDRHAMLRLRAADVENLTVPESGAVTAR-----------GCLRTVHRLS Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M IQQVPSDQEVEPGSVGDMARRYVDMIQAHHPDGPYNLLGWSMGGVVAHEI Mb0104|M.bovis_AF2122/97 VLELLRRLDVDG-RLICLVRAESDEDARRRLEKTFDSGDPELLRHFKELA Rv0101|M.tuberculosis_H37Rv VLELLRRLDVDG-RLICLVRAESDEDARRRLEKTFDSGDPELLRHFKELA MLBr_00484|M.leprae_Br4923 ALKWLERMDLVEGKVIALVRAKSNEDARARLDKTFDSGDPKLLAHYQELA MUL_1722|M.ulcerans_Agy99 ALEWLERMDLVDGKLICLVRAKSDTEARARLEKTFDSGAPELLAHYRALA Mvan_2578|M.vanbaalenii_PYR-1 ALEWLERMALVGGKLICLVRAKDDAAARVRLDSTFDSGDPELLRHYRRLA MAB_4098c|M.abscessus_ATCC_199 ADRLQVIAGDKAEPSLGLDQDTWQRLADTVDLIVDSAALVNSVLPYSELF MSMEG_0402|M.smegmatis_MC2_155 TERLQVVAGDKGQPNLGLDEQTWQRLAESVDLIVDSAAFVNSVLPYSELF MAV_3243|M.avium_104 EEHLQVVAGDKGQANLGLDEQTWQQLADTVDLIVDSAAVVNGVLPYSELF TH_3730|M.thermoresistible__bu GDELRSARAELDPAAGTMVRALWAPDTRRLALIVHHLAVD---------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M AVELRRRGCEVGRLIVLDAAGEVDSADS---------------------- Mb0104|M.bovis_AF2122/97 ADRLEVVAGDKSEPDLGLDQPMWRRLAETVDLIVDSAAMVN-AFPYHELF Rv0101|M.tuberculosis_H37Rv ADRLEVVAGDKSEPDLGLDQPMWRRLAETVDLIVDSAAMVN-AFPYHELF MLBr_00484|M.leprae_Br4923 TDHLEVIAGDKGEVDLELDRQTWRRLADTVDLIVDPAALVNHVLPYSELF MUL_1722|M.ulcerans_Agy99 GDHLEVLAGDKGEADLGLDRQTWQRLADTVDLIVDPAALVNHVLPYSQLF Mvan_2578|M.vanbaalenii_PYR-1 ADHLEVIAGDKADADLGLDARTWQRLADTVDLIVDPAALVNHVLPYRQLF MAB_4098c|M.abscessus_ATCC_199 GPNVVGTAELIRFALTTKLKPYTYISTADVGREIEKSVFREDADIRVISA MSMEG_0402|M.smegmatis_MC2_155 GPNVVGTAELIRFALTSKLKPFNFVSTSDVGRQIEPSRFTEQADIRLVSA MAV_3243|M.avium_104 TPNVGGTAELIRLALTTRKKPFAYVSTSDVGRQIEPSAFTEDADIRVISA TH_3730|M.thermoresistible__bu AVSWRILVEDINIAWGQR----------HTGQPIDLP------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M -------------------------------------------------- Mb0104|M.bovis_AF2122/97 GPNVAGTAELIRIALTTKLKPFTYVSTADVGAAIEPSAFTEDADIRVISP Rv0101|M.tuberculosis_H37Rv GPNVAGTAELIRIALTTKLKPFTYVSTADVGAAIEPSAFTEDADIRVISP MLBr_00484|M.leprae_Br4923 GPNTLGTAELIRIALTSKQKPYIYVSTIGVGNQIEPAKFTEDSDIRVISP MUL_1722|M.ulcerans_Agy99 GPNALGTAELLRLALTSKIKPYSYTSTIGVADQIPPSAFTEDADIRVISA Mvan_2578|M.vanbaalenii_PYR-1 APNVLGTAELLRIALTTRMKPFVYVSTIGVGAGIEPARFTEDADIRQISA MAB_4098c|M.abscessus_ATCC_199 TRPSDGSYANGYGNSKWAGEVLLREAHEQVGLPVKVFRSGMIMVDTSYAG MSMEG_0402|M.smegmatis_MC2_155 TRKIEVGYANGYGNSKWAGEVLLREAHDHCGLPVAVFRSGMIMVDPTYAG MAV_3243|M.avium_104 TRVIDGSYANGYGNSKWAGEVLLREAHDLCGLPVSVFRSDMILADTSYAG TH_3730|M.thermoresistible__bu --------AGGTSFARWS--TLLAEYADTP----------------EVVA Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M --------------------------------------------VAEPAS Mb0104|M.bovis_AF2122/97 TRTVDGGWAGGYGTSKWAGEVLLREANDLCALPVAVFRCGMILADTSYAG Rv0101|M.tuberculosis_H37Rv TRTVDGGWAGGYGTSKWAGEVLLREANDLCALPVAVFRCGMILADTSYAG MLBr_00484|M.leprae_Br4923 TRNINNNYANGYGNSKWAGEVLLREAHDLCGLPVTVFRCDMILADTSYAG MUL_1722|M.ulcerans_Agy99 TRAVDDSYANGYSNSKWAGEVLLREAHVLCGLPVAVFRCDMILADTTWAG Mvan_2578|M.vanbaalenii_PYR-1 TRRIDDSYANGYGNSKWAGEVLLREAHDLCGLPVSVFRCDMILADTTYAG MAB_4098c|M.abscessus_ATCC_199 QVNASDTVARMVLSVVATGVAPYSVYQLDADGNRQRAHFDGLPVEFVAEA MSMEG_0402|M.smegmatis_MC2_155 QLNVTDTVSRMVLSIVATGVAPGSFYQRGDNGERQRAHFDGLPVDFVAQA MAV_3243|M.avium_104 QLNVTDIFTRMILSIVATGTAPKSFYRLDADGNRQRSHFDALPVEFVAEA TH_3730|M.thermoresistible__bu QAGVWQQVAAXXWPSCSTPTTTS-----SSTSTWRSTRSTGRPVRTGCST Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M ESDVLELILVAAGIDIAEHPRPLTYHEAEALLNQRTPVEFSLPPRRIVEI Mb0104|M.bovis_AF2122/97 QLNMSDWVTRMVLSLMATGIAPRSFYEPDSEGNRQRAHFDGLPVTFVAEA Rv0101|M.tuberculosis_H37Rv QLNMSDWVTRMVLSLMATGIAPRSFYEPDSEGNRQRAHFDGLPVTFVAEA MLBr_00484|M.leprae_Br4923 QLNVPDMFTRMMLSLAATGIAPGSFYELDAESNRQRAHYDGLPVEFIAEA MUL_1722|M.ulcerans_Agy99 QLNVPDMFTRMILSLAATGIAPGSFYELAADGARQRAHYDGLPVEFIAEA Mvan_2578|M.vanbaalenii_PYR-1 QLNLPDMFTRLIFSLVATGVAPESFYHLATDGTRQRAHYDGLPVEFIAEA MAB_4098c|M.abscessus_ATCC_199 ----ITALGGGAAGSFDGS--ADFETYHVMNPHDDGIGIDEYVDWLIEAG MSMEG_0402|M.smegmatis_MC2_155 ----ITKLGWQVARSVTDSTASGFETYHVMNPHDDGIGIDTYIDWLIEAG MAV_3243|M.avium_104 ----IAKLGAQVMD--------GFETYHVMNPHDDGIGLDEYVDWLIEAG TH_3730|M.thermoresistible__bu ----RCSS------------------------------------------ Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M MLDN---------------------------------------------- Mb0104|M.bovis_AF2122/97 IAVLGARVAG--------SSLAGFATYHVMNPHDDGIGLDEYVDWLIEAG Rv0101|M.tuberculosis_H37Rv IAVLGARVAG--------SSLAGFATYHVMNPHDDGIGLDEYVDWLIEAG MLBr_00484|M.leprae_Br4923 ISTLGDQSL---------HDRDGFTTYHVMNPHDDGIGMDEFVDWLIDAG MUL_1722|M.ulcerans_Agy99 ISTLGAQ------------SQDGFHTYHVMNPYDDGIGLDEFVDWLNESG Mvan_2578|M.vanbaalenii_PYR-1 ISTLGSD------------VASGFRTYHVMNPHDDGIGLDEYVDWLIDAG MAB_4098c|M.abscessus_ATCC_199 HPIERIDDFGEWVRQFEARLHALPDHQRQGSVLQMLKILQDHGWDGQPPE MSMEG_0402|M.smegmatis_MC2_155 YPIERIEDFGEWLQRFEAALQGLSDQQRQNSVLQMLTLLKQQAGELQPPV MAV_3243|M.avium_104 YPIERVDDFGEWLQRFETGLRGLPERQRQNSVLQMLLLLLRDPKNLQLAE TH_3730|M.thermoresistible__bu ----------------------------TRTIRSMRRRWPGRKALRSPIS Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M ------------------------MNANQSMRLKHVPDVFDGDMIVFSAK Mb0104|M.bovis_AF2122/97 YPIRRIDDFAEWLQRFEASLGALPDRQRRHSVLPMLLASNSQR--LQPLK Rv0101|M.tuberculosis_H37Rv YPIRRIDDFAEWLQRFEASLGALPDRQRRHSVLPMLLASNSQR--LQPLK MLBr_00484|M.leprae_Br4923 CPIQRINDYDEWLRRFEISLRALPERQRHSSLLPLLHNYQ------KPEK MUL_1722|M.ulcerans_Agy99 CPIQRIADYGDWLQRFETALRALPDRQRHSSLLPLLHNYR------QPER Mvan_2578|M.vanbaalenii_PYR-1 HPIRRVGDYPTWLQRFTVAITALPERQRQASLLPLLHNYQ------HPET MAB_4098c|M.abscessus_ATCC_199 PVRGPMAPADRFHAAVRKAKIGSDHD---IPQVSAPIIAKYASDLQLHGL MSMEG_0402|M.smegmatis_MC2_155 PTRGSFAPADRFQAAVRDANIGVEGE---IPHVTREVIVKYVTDLQLLGL MAV_3243|M.avium_104 PARGAFAPTDRFRAAVQEAKVGSDND---IPHISAPVIVKYVTDLQLLGL TH_3730|M.thermoresistible__bu RAANTTTIRCRWSQCPGTSSDCASNT---TPRCSTPRMSRHWSAGCGGC- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M RDSGGRSLADSWRQYVAGDITEYPID---CTHEAMLNIESLQLFADRIAI Mb0104|M.bovis_AF2122/97 PTRGCSAPTDRFRAAVRAAKVGSDKDNPDIPHVSAPTIINYVTNLQLLGL Rv0101|M.tuberculosis_H37Rv PTRGCSAPTDRFRAAVRAAKVGSDKDNPDIPHVSAPTIINYVTNLQLLGL MLBr_00484|M.leprae_Br4923 PLHGSLAPTIRFRTAVQNANIGQDKD---IPHISPAIIAKYVSDLQLLGL MUL_1722|M.ulcerans_Agy99 PVRGSIAPTDRFRAAVQEAKIGPDKD---IPHVGAPIIVKYVSDLRLLGL Mvan_2578|M.vanbaalenii_PYR-1 PIRGSIAPTDRFREAVQDAKIGPDKD---IPHVTPQIVIKYVTDLQRLGL MAB_4098c|M.abscessus_ATCC_199 L-- MSMEG_0402|M.smegmatis_MC2_155 L-- MAV_3243|M.avium_104 L-- TH_3730|M.thermoresistible__bu --- Mflv_2697|M.gilvum_PYR-GCK --- MMAR_0099|M.marinum_M YLR Mb0104|M.bovis_AF2122/97 L-- Rv0101|M.tuberculosis_H37Rv L-- MLBr_00484|M.leprae_Br4923 V-- MUL_1722|M.ulcerans_Agy99 L-- Mvan_2578|M.vanbaalenii_PYR-1 L--