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STDTREDRLARRIADLYATDPQFAAAAPDDAISHAIDQPGTHLPVIVQTVLDGYAERPALGQRAVRFVTD PATGRTTTELLPRFETITYAELSRRIHAVTAALTDVHPGDRVAVLGFTSIDYTTVDMALAMLGAVAVPLQ TSAPATTVRPIVAETEPVVIASSVDALTDAVGLALDAPTVTRLVVFDHRAGVDDHRDALISASDRLRAAN SPIEVETITDIVARGSKLPVRAQFSADGDALSLLIYTSGSTGAPKGAMYPQHLVANSWRRLARSFWGDLG VFPAITLNFMPMSHVMGRGLLYGTLDAGGTAYFAARSDLSTFLEDLALVRPTQLSFVPRIWDTIHAEVSQ ELERRPSDATEVIADLRRSLLGGRYVTAMTGSAPLSPEMRAFVENLLDVHLIDGYGSTEAGAVFVDGRVQ RPPVIDYKLVDVADLGYFSTDRPHPRGELLVKSETLFPGYYKRPDVTAEMFDEDGYYRTGDIVAETGADQ LTYLDRRNNVLKLSQGEFVTVSRLEAVFGNSPLVRQIYVYGNSARPYLLAVVVPTEAALAGADAKAAVAE SLQDVAKATGLQSYEIPRDFLLETTPFTLENGLLTGIRKLARPRLRERYGEQLEALYTMLSEEQADELRE LRRSGGERPALETVGRAAGALLGTTAGELEPSAHFTDLGGDSLSALTFANLLRDIFDVDVPVGVIVSPAT DLQALADYVESARRHGSVRPTFESVHGHSGRPGTEVHARDLTLDEFVDAATLAHAPTLPGPRAEVRTVLL TGATGFLGRYLALEWLERMALVGGKLICLVRAKDDAAARVRLDSTFDSGDPELLRHYRRLAADHLEVIAG DKADADLGLDARTWQRLADTVDLIVDPAALVNHVLPYRQLFAPNVLGTAELLRIALTTRMKPFVYVSTIG VGAGIEPARFTEDADIRQISATRRIDDSYANGYGNSKWAGEVLLREAHDLCGLPVSVFRCDMILADTTYA GQLNLPDMFTRLIFSLVATGVAPESFYHLATDGTRQRAHYDGLPVEFIAEAISTLGSDVASGFRTYHVMN PHDDGIGLDEYVDWLIDAGHPIRRVGDYPTWLQRFTVAITALPERQRQASLLPLLHNYQHPETPIRGSIA PTDRFREAVQDAKIGPDKDIPHVTPQIVIKYVTDLQRLGLL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2578 | - | - | 100% (1162) | thioester reductase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_1594 | - | 4e-33 | 25.74% (540) | AMP-dependent synthetase and ligase |
| M. vanbaalenii PYR-1 | Mvan_3549 | - | 2e-29 | 24.83% (584) | AMP-dependent synthetase and ligase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2621 | fadD9 | 0.0 | 66.72% (1175) | fatty-acid-CoA ligase |
| M. gilvum PYR-GCK | Mflv_2962 | - | 4e-37 | 25.88% (568) | AMP-dependent synthetase and ligase |
| M. tuberculosis H37Rv | Rv2590 | fadD9 | 0.0 | 66.89% (1175) | fatty-acid-CoA ligase |
| M. leprae Br4923 | MLBr_00484 | fadD9 | 0.0 | 65.23% (1182) | putative acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_2962 | - | 0.0 | 56.41% (1186) | fatty-acid-CoA ligase FadD |
| M. marinum M | MMAR_2117 | fadD9 | 0.0 | 69.15% (1180) | fatty-acid-CoA ligase FadD9 |
| M. avium 104 | MAV_3471 | - | 0.0 | 69.09% (1181) | putative acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2956 | - | 0.0 | 70.98% (1175) | NAD dependent epimerase/dehydratase family protein |
| M. thermoresistible (build 8) | TH_1879 | fadD9 | 1e-166 | 58.80% (517) | PROBABLE FATTY-ACID-CoA LIGASE FADD9 (FATTY-ACID-CoA |
| M. ulcerans Agy99 | MUL_1722 | - | 0.0 | 68.73% (1180) | fatty-acid-CoA ligase FadD9 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_2578|M.vanbaalenii_PYR-1 --------------MSTDTREDR-LARRIADLYATDPQFAAAAPDDAISH
MSMEG_2956|M.smegmatis_MC2_155 --------------MTIETREDR-FNRRIDHLFETDPQFAAARPDEAISA
MLBr_00484|M.leprae_Br4923 MWRQQSISHRKESVMSTITKQEKQLARRVDDLTANDPQFAAAKPDPAVAA
MAV_3471|M.avium_104 --------------MSTATHDER-LDRRVHELIATDPQFAAAQPDPAITA
Mb2621|M.bovis_AF2122/97 --------------MS--INDQR-LTRRVEDLYASDAQFAAASPNEAITQ
Rv2590|M.tuberculosis_H37Rv --------------MS--INDQR-LTRRVEDLYASDAQFAAASPNEAITQ
MMAR_2117|M.marinum_M --------------MSPITREER-LERRIQDLYANDPQFAAAKPATAITA
MUL_1722|M.ulcerans_Agy99 --------------MSPITREER-LERRIQDLYANDPQFAAAKPVTAITA
TH_1879|M.thermoresistible__bu --------------------------------------------------
MAB_2962|M.abscessus_ATCC_1997 -----------MTVTNETNPQQEQLSRRIESLRESDPQFRAAQPDPAVAE
Mflv_2962|M.gilvum_PYR-GCK ---------------------------MTAREFTVPAPFTVEERDNIVGA
Mvan_2578|M.vanbaalenii_PYR-1 AIDQPGTHLPVIVQTVLDGYAERPALGQRAVRFVTDPATGRTTTELLPRF
MSMEG_2956|M.smegmatis_MC2_155 AAADPELRLPAAVKQILAGYADRPALGKRAVEFVTD-EEGRTTAKLLPRF
MLBr_00484|M.leprae_Br4923 ALAQPGLRLPQIIQTALDGYAERPALGQRVAEFTKDPKTGRTSMELLPSF
MAV_3471|M.avium_104 ALEQPGLRLPQIIRTVLDGYADRPALGQRVVEFVTDAKTGRTSAQLLPRF
Mb2621|M.bovis_AF2122/97 AIDQPGVALPQLIRMVMEGYADRPALGQRALRFVTDPDSGRTMVELLPRF
Rv2590|M.tuberculosis_H37Rv AIDQPGVALPQLIRMVMEGYADRPALGQRALRFVTDPDSGRTMVELLPRF
MMAR_2117|M.marinum_M AIERPGLPLPQIIETVMTGYADRPALAQRSVEFVTDAGTGHTTLRLLPHF
MUL_1722|M.ulcerans_Agy99 AIERPGLPLPQIIETVMTGYADRPALAQRSVEFVTDAGTGHTTLRLLPHF
TH_1879|M.thermoresistible__bu --------------------------------------------------
MAB_2962|M.abscessus_ATCC_1997 QVLRPGLHLSEAIAALMTGYAERPALGERARELVTD-QDGRTTLRLLPRF
Mflv_2962|M.gilvum_PYR-GCK VFTHERDDPDHVIFQRLVDG----------------------------KW
Mvan_2578|M.vanbaalenii_PYR-1 ETITYAELSRRIHAVTAALT-----DVHPGDRVAVLGFTSIDYTTVDMAL
MSMEG_2956|M.smegmatis_MC2_155 DTITYRQLAGRIQAVTNAWHNH---PVNAGDRVAILGFTSVDYTTIDIAL
MLBr_00484|M.leprae_Br4923 ETITYRQLGDRVGALARAWRHD---LLHAGYRVCVLGFNSVDYAIIDMAL
MAV_3471|M.avium_104 ETITYGEVAQRVSALGRALSDD---AVHPGDRVCVLGFNSVDYATIDMAL
Mb2621|M.bovis_AF2122/97 ETITYRELWARAGTLATALSAEP--AIRPGDRVCVLGFNSVDYTTIDIAL
Rv2590|M.tuberculosis_H37Rv ETITYRELWARAGTLATALSAEP--AIRPGDRVCVLGFNSVDYTTIDIAL
MMAR_2117|M.marinum_M ETISYGELWDRISALADVLSTEQ--TVKPGDRVCLLGFNSVDYATIDMTL
MUL_1722|M.ulcerans_Agy99 ETISYGELWDRISALADVLSTEQ--TVKPSDRVCLLGFNSVDYATIDMTL
TH_1879|M.thermoresistible__bu --------------------------------------------------
MAB_2962|M.abscessus_ATCC_1997 DTTTYGELWSRTTSVAAAWHHDAAHPVKAGDLVATLGFTSIDYTVLDLAI
Mflv_2962|M.gilvum_PYR-GCK IDVTARQAAGQIRSAARGLIAEG---VQAGDRVALLSATRYEWPILDFAI
Mvan_2578|M.vanbaalenii_PYR-1 AMLGAVAVPLQTSAPATTVRPIVAETEPVVIASSVDALTDAVGLALDAPT
MSMEG_2956|M.smegmatis_MC2_155 LELGAVSVPLQTSAPVAQLQPIVAETEPKVIASSVDFLADAVALVESGPA
MLBr_00484|M.leprae_Br4923 GVIGAVAVPLQTSAAITQLQSIVTETEPSMIATSVNQLPDTVELIL-SGQ
MAV_3471|M.avium_104 GAIGAVSVPLQTSAAISSLQPIVAETEPTLIASSVNQLSDAVQLITGAEQ
Mb2621|M.bovis_AF2122/97 IRLGAVSVPLQTSAPVTGLRPIVTETEPTMIATSIDNLGDAVEV-LAGHA
Rv2590|M.tuberculosis_H37Rv IRLGAVSVPLQTSAPVTGLRPIVTETEPTMIATSIDNLGDAVEV-LAGHA
MMAR_2117|M.marinum_M ARLGAVAVPLQTSAAITQLQPIVAETQPTMIAASVDALADATELALSGQT
MUL_1722|M.ulcerans_Agy99 ARLGAVAVPLQTSAAITQLQPIVAETQPTMIAASVDALADATELALSGQT
TH_1879|M.thermoresistible__bu --------------------------------------------------
MAB_2962|M.abscessus_ATCC_1997 MILGGVAVPLQTSAPASQWTTILAEAEPNTLAVSIELIGAAMESVRATPS
Mflv_2962|M.gilvum_PYR-GCK LSIGAVTVPIYETSSAEQVQFVLADSGAVAAIAETDAHAAHIEAQRDTLP
Mvan_2578|M.vanbaalenii_PYR-1 V-TRLVVFDHRAGVDDHRDALISASDRLRAANSPIEVETITDIVARG---
MSMEG_2956|M.smegmatis_MC2_155 P-SRLVVFDYSHEVDDQREAFEAAKGKLAGTG--VVVETITDALDRG---
MLBr_00484|M.leprae_Br4923 APAKLVVFDYHPEVDEQHDAVATARARLADSS--VVVESLTEVLGRG---
MAV_3471|M.avium_104 APTRLVVFDYHPQVDDQREAVQDAAARLSGTG--VAVQTLAELLERG---
Mb2621|M.bovis_AF2122/97 P-ARLVVFDYHGKVDTHREAVEAARARLAGS---VTIDTLAELIER----
Rv2590|M.tuberculosis_H37Rv P-ARLVVFDYHGKVDTHREAVEAARARLAGS---VTIDTLAELIER----
MMAR_2117|M.marinum_M A-TRVLVFDHHRQVDAHRAAVESARERLAGS---AVVETLAEAIARGDVP
MUL_1722|M.ulcerans_Agy99 A-TRVLVFDHHRQVDAHRAAVESARERLAGS---AVVETLAEAIARGDVP
TH_1879|M.thermoresistible__bu --------------------------------------------------
MAB_2962|M.abscessus_ATCC_1997 I-KQVVVFDYTPEVDDQREAFEAASTQLAGTG--IAIETLDAVIARG---
Mflv_2962|M.gilvum_PYR-GCK ALRRIYVIDGSVPALDELAEAGASVD------------------------
Mvan_2578|M.vanbaalenii_PYR-1 -SKLPVRAQFS-ADGDALSLLIYTSGSTGAPKGAMYPQHLVANSWRRLAR
MSMEG_2956|M.smegmatis_MC2_155 -RSLADAPLYVPDEADPLTLLIYTSGSTGTPKGAMYPESKTATMWQAGSK
MLBr_00484|M.leprae_Br4923 KTLPATPIPVADDSADPLALLIYTSGSTGAPKGAMYLQSNVGKMWRRSDG
MAV_3471|M.avium_104 KDLPAVAEPPADE--DSLALLIYTSGSTGAPKGAMYPQSNVGKMWRRGSK
Mb2621|M.bovis_AF2122/97 -GRALPATPIADSADDALALLIYTSGSTGAPKGAMYRESQVMSFWRKSSG
Rv2590|M.tuberculosis_H37Rv -GRALPATPIADSADDALALLIYTSGSTGAPKGAMYRESQVMSFWRKSSG
MMAR_2117|M.marinum_M RGASAGSAPGTDVSDDSLALLIYTSGSTGAPKGAMYPRRNVATFWRKRT-
MUL_1722|M.ulcerans_Agy99 RGASAGSAPGTDVSDDSLALLIYTSGSTGAPKGAMYPRRNVATFWRKRT-
TH_1879|M.thermoresistible__bu --------------------------------------------------
MAB_2962|M.abscessus_ATCC_1997 AALPAAPLYAPSAGDDPLALLIYTSGSTGAPKGAMHSENIVRRWWIREDV
Mflv_2962|M.gilvum_PYR-GCK --AAAVDERVASIRSTDAATLIYTSGTTGRPKGCQLTHSNLLYEIRGAKA
Mvan_2578|M.vanbaalenii_PYR-1 SFWGD-LGVFPAITLNFMPMSHVMGRGLLYGTLDAGGTAYFAARSDLSTF
MSMEG_2956|M.smegmatis_MC2_155 ARWDETLGVMPSITLNFMPMSHVMGRGILCSTLASGGTAYFAARSDLSTF
MLBr_00484|M.leprae_Br4923 NWFGP---TAASITLNFMPMSHVMGRGILYGTLGNGGTAYFAARSDLSTL
MAV_3471|M.avium_104 NWFGE---SAASITLNFMPMSHVMGRSILYGTLGNGGTAYFAARSDLSTL
Mb2621|M.bovis_AF2122/97 WFEPS---GYPSITLNFMPMSHVGGRQVLYGTLSNGGTAYYVAKSDLSTL
Rv2590|M.tuberculosis_H37Rv WFEPS---GYPSITLNFMPMSHVGGRQVLYGTLSNGGTAYFVAKSDLSTL
MMAR_2117|M.marinum_M WFEGG---YEPSITLNFMPMSHVMGRQILYGTLCNGGTAYFVAKSDLSTL
MUL_1722|M.ulcerans_Agy99 WFEGG---YEPSITLNFMPMSHVMGRQILYGTLCNGGTAYFVVKSDLSTL
TH_1879|M.thermoresistible__bu --------------------------------------------------
MAB_2962|M.abscessus_ATCC_1997 MAGTEN---LPMIGLNFMPMSHIMGRGTLTSTLSTGGTGYFAASSDMSTL
Mflv_2962|M.gilvum_PYR-GCK CFPEH--LAKGEKLLVFLPLAHVLARALTIGAFSNG--VTLGFTSDIKNL
Mvan_2578|M.vanbaalenii_PYR-1 LEDLALVRPTQLSFVPRIWDTIHAEVSQELERRPSD----ATE------V
MSMEG_2956|M.smegmatis_MC2_155 LEDLALVRPTQLNFVPRIWDMLFQEYQSRLDNRRAE----GSEDRAEAAV
MLBr_00484|M.leprae_Br4923 LEDLKLVRPTELNFVPRIWETLYDESKRAVDRRLANSGSA-DRAAIKAEV
MAV_3471|M.avium_104 LEDLELVRPTELNFVPRIWETLYGEFQRQVERRLSEAGDAGERRAVEAEV
Mb2621|M.bovis_AF2122/97 FEDLALVRPTELCFVPRIWDMVFAEFHSEVDRRLVD---GADRAALEAQV
Rv2590|M.tuberculosis_H37Rv FEDLALVRPTELCFVPRIWDMVFAEFHSEVDRRLVD---GADRAALEAQV
MMAR_2117|M.marinum_M FEDLALVRPTELTFVPRVWDMVFDEFQSEVDRRLVD---GADRVALEAQV
MUL_1722|M.ulcerans_Agy99 FEDLALVRPTELTFVPRVWDMVFDEFQSEVDRRLVD---GADRVALEAQV
TH_1879|M.thermoresistible__bu --------------------------------------------------
MAB_2962|M.abscessus_ATCC_1997 FEDMELIRPTALALVPRVCDMVFQRFQTEVDRRLASS-DTASAEAVAAEV
Mflv_2962|M.gilvum_PYR-GCK VPMFAVFQPTLVVSVPRVFEKVYN--------------------------
Mvan_2578|M.vanbaalenii_PYR-1 IADLRRSLLGGRYVTAMTGSAPLSPEMRAFVENLL-DVHLIDGYGSTEAG
MSMEG_2956|M.smegmatis_MC2_155 LEEVRTQLLGGRFVSALTGSAPISAEMKSWVEDLL-DMHLLEGYGSTEAG
MLBr_00484|M.leprae_Br4923 MDEQRQSLLGGRYIAAMTGSAPTSPELKHGVESLL-EMHLLEGYGSTEAG
MAV_3471|M.avium_104 LAEQRQYLLGGRFTFAMTGSAPISPELRNWVESLL-EMHLMDGYGSTEAG
Mb2621|M.bovis_AF2122/97 KAELRENVLGGRFVMALTGSAPISAEMTAWVESLLADVHLVEGYGSTEAG
Rv2590|M.tuberculosis_H37Rv KAELRENVLGGRFVMALTGSAPISAEMTAWVESLLADVHLVEGYGSTEAG
MMAR_2117|M.marinum_M KAEIRNDVLGGRYTSALTGSAPISDEMKAWVEELL-DMHLVEGYGSTEAG
MUL_1722|M.ulcerans_Agy99 KAEIRNDVLGGRYTSALTGSAPISDEMKAWVEELL-DMHLVEGYGSTEAG
TH_1879|M.thermoresistible__bu --------------------------------------------------
MAB_2962|M.abscessus_ATCC_1997 KADIRDNLFGGRVSAVMVGSAPLSEELGEFIESCF-ELNLTDGYGSTEAG
Mflv_2962|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2578|M.vanbaalenii_PYR-1 AVFVDGRVQRPPVIDYKLVDVADLGYFSTDRPHPRGELLVKSETLFPGYY
MSMEG_2956|M.smegmatis_MC2_155 AVFIDGQIQRPPVIDYKLVDVPDLGYFATDRPYPRGELLVKSEQMFPGYY
MLBr_00484|M.leprae_Br4923 MVLFDGEVQRPPVIDYKLVDVPDLGYFSTDQPYPRGELLLKTQNMFPGYY
MAV_3471|M.avium_104 MVLFDGEIQRPPVVDYKLVDVPDLGYFSTDRPHPRGELLLRTENMFPGYY
Mb2621|M.bovis_AF2122/97 MVLNDGMVRRPAVIDYKLVDVPELGYFGTDQPYPRGELLVKTQTMFPGYY
Rv2590|M.tuberculosis_H37Rv MVLNDGMVRRPAVIDYKLVDVPELGYFGTDQPYPRGELLVKTQTMFPGYY
MMAR_2117|M.marinum_M MILIDGAIRRPAVLDYKLVDVPDLGYFLTDRPHPRGELLVKTDSLFPGYY
MUL_1722|M.ulcerans_Agy99 MILIDGAIRRPAVLDYKLVDVPDLGYFLTDRPHPRGELLVKTDSLFPGYY
TH_1879|M.thermoresistible__bu --------------------------------------------------
MAB_2962|M.abscessus_ATCC_1997 MVFRDGIVQRPPVIDYKLVDVPELGYFSTDKPHPRGELLLKTDGMFLGYY
Mflv_2962|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2578|M.vanbaalenii_PYR-1 KRPDVTAEMFDEDGYYRTGDIVAETGADQLTYLDRRNNVLKLSQGEFVTV
MSMEG_2956|M.smegmatis_MC2_155 KRPEITAEMFDEDGYYRTGDIVAELGPDHLEYLDRRNNVLKLSQGEFVTV
MLBr_00484|M.leprae_Br4923 KRPEVTATVFDSDGYYQTGDIVAEVGPDRLVYVDRRNNVLKLAQGQFVTV
MAV_3471|M.avium_104 KRAETTAGVFDEDGYYRTGDVFAEIAPDRLVYVDRRNNVLKLAQGEFVTL
Mb2621|M.bovis_AF2122/97 QRPDVTAEVFDPDGFYRTGDIMAKVGPDQFVYLDRRNNVLKLSQGEFIAV
Rv2590|M.tuberculosis_H37Rv QRPDVTAEVFDPDGFYRTGDIMAKVGPDQFVYLDRRNNVLKLSQGEFIAV
MMAR_2117|M.marinum_M QRAEVTADVFDADGFYRTGDIMAEVGPEQFVYLDRRNNVLKLSQGEFVTV
MUL_1722|M.ulcerans_Agy99 QRAEVTADVFDADGFYRTGDIMAEVGPEQFVYLDRRNNVLKLSQGEFVTV
TH_1879|M.thermoresistible__bu --------------------------------------------------
MAB_2962|M.abscessus_ATCC_1997 KRPEVTAGVFDADGFYMTGDIVAELAHDNIEIIDRRNNVLKLSQGEFVAV
Mflv_2962|M.gilvum_PYR-GCK -----------------TAELNAETGGKGKIFTAAANTAIEYS-------
Mvan_2578|M.vanbaalenii_PYR-1 SRLEAVFGNSPLVRQIYVYGNSARPYLLAVVVPTEAALA-----GADAKA
MSMEG_2956|M.smegmatis_MC2_155 SKLEAVFGDSPLVRQIYVYGNSARSYLLAVVVPTEEALSRWD--GDELKS
MLBr_00484|M.leprae_Br4923 AKLEAAFSNSPLVRQIYIYGNSAHPYLLAVVVPTEDALATND--IEVLKP
MAV_3471|M.avium_104 AKLEAVFGNSPLIRQIYVYGNSAQPYLLAVVVPTEEALASGD--PETLKP
Mb2621|M.bovis_AF2122/97 SKLEAVFGDSPLVRQIFIYGNSARAYPLAVVVPSGDALSRHG--IENLKP
Rv2590|M.tuberculosis_H37Rv SKLEAVFGDSPLVRQIFIYGNSARAYPLAVVVPSGDALSRHG--IENLKP
MMAR_2117|M.marinum_M SKLEAVFGDSPLVRQIYIYGNSARAYLLAVIVPTQEALDAVP--VEELKA
MUL_1722|M.ulcerans_Agy99 SKLEAVFGDSPLVRQIYIYGNSARAYLLAVIVPTQEALDAVP--VEELKA
TH_1879|M.thermoresistible__bu --------------------------------------------------
MAB_2962|M.abscessus_ATCC_1997 ATLEAEYANSPVVHQIYVYGSSERSYLLAVVVPTPEAVAAAKGDAAALKT
Mflv_2962|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2578|M.vanbaalenii_PYR-1 AVAESLQDVAKATG-LQSYEIPRDFLLETTPFTLENGLLTGIRKLARPRL
MSMEG_2956|M.smegmatis_MC2_155 RISDSLQDAARAAG-LQSYEIPRDFLVETTPFTLENGLLTGIRKLARPKL
MLBr_00484|M.leprae_Br4923 LIIDSLQKVAKEAD-LQSYEVPRDLIVETTPFSLENGLLTGIRKLAWPKL
MAV_3471|M.avium_104 KIADSLQQVAKEAG-LQSYEVPRDFIIETTPFSLENGLLTGIRKLAWPKL
Mb2621|M.bovis_AF2122/97 VISESLQEVARAAG-LQSYEIPRDFIIETTPFTLENGLLTGIRKLARPQL
Rv2590|M.tuberculosis_H37Rv VISESLQEVARAAG-LQSYEIPRDFIIETTPFTLENGLLTGIRKLARPQL
MMAR_2117|M.marinum_M RLGDSLQEVAKAAG-LQSYEIPRDFIIETTPWTLENGLLTGIRKLARPQL
MUL_1722|M.ulcerans_Agy99 RLGDSLQEVAKAAG-LQSYEIPRDFIIETTPWTLQNGLLTGIRKLARPQL
TH_1879|M.thermoresistible__bu -VGLSXQARARLADRLPAYMVPAAVVVLDRIPLTVNGKLD-RRALPAPEY
MAB_2962|M.abscessus_ATCC_1997 TIADSLQDIAKEIQ-LQSYEVPRDFIIEPQPFTQGNGLLTGIAKLARPNL
Mflv_2962|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2578|M.vanbaalenii_PYR-1 RERYGEQLEALYTMLSEEQADELRELRRSGGERPALETVGRAAGALLGTT
MSMEG_2956|M.smegmatis_MC2_155 KAHYGERLEQLYTDLAEGQANELRELRRNGADRPVVETVSRAAVALLGAS
MLBr_00484|M.leprae_Br4923 KQHYGARLEQLYADLVEGQANALHVLKQSVANAPVLQTVSRAVGTILGVA
MAV_3471|M.avium_104 KQHYGERLEQMYADLAAGQADELAELRRNGAQAPVLQTVSRAAGAMLGSA
Mb2621|M.bovis_AF2122/97 KKFYGERLERLYTELADSQSNELRELRQSGPDAPVLPTLCRAAAALLGST
Rv2590|M.tuberculosis_H37Rv KKFYGERLERLYTELADSQSNELRELRQSGPDAPVLPTLCRAAAALLGST
MMAR_2117|M.marinum_M KKHYGELLEQIYTDLAHGQADELRSLRQSGADAPVLVTVCRAAAALLGGS
MUL_1722|M.ulcerans_Agy99 KKHYGELLEQIYTDLAHGQADELRSLRQSGADAPVLVTVCRAAAALLGGS
TH_1879|M.thermoresistible__bu QRAD----------------------RYRAPETAVEKTLTEIFAHVLG--
MAB_2962|M.abscessus_ATCC_1997 KAHYGPRLEQMYAEIAEQQAAELRALHGVDPDKPALETVLKAAQALLGVS
Mflv_2962|M.gilvum_PYR-GCK -----------------------KALDSGGPGLVLKLKHALFDKLVYGKL
. : *
Mvan_2578|M.vanbaalenii_PYR-1 AGELEPSAHFTDLGGDSLSALTFANLLRDIFDVDVPVGVIVSPATDLQAL
MSMEG_2956|M.smegmatis_MC2_155 VTDLRSDAHFTDLGGDSLSALSFSNLLHEIFDVDVPVGVIVSPATDLAGV
MLBr_00484|M.leprae_Br4923 TTDLPSNAHFTDLGGDSLSALTFGSLLRELFDIDVPVGVIVSPVNNLVAI
MAV_3471|M.avium_104 ASDLSPDAHFTDLGGDSLSALTFGNLLREIFDVDVPVGVIVSPANDLAAI
Mb2621|M.bovis_AF2122/97 AADVRPDAHFADLGGDSLSALSLANLLHEIFGVDVPVGVIVSPASDLRAL
Rv2590|M.tuberculosis_H37Rv AADVRPDAHFADLGGDSLSALSLANLLHEIFGVDVPVGVIVSPASDLRAL
MMAR_2117|M.marinum_M ASDVQPDAHFTDLGGDSLSALSFTNLLHEIFDIEVPVGVIVSPANDLQAL
MUL_1722|M.ulcerans_Agy99 ASDVQPDAHFTDLGGDSLSALSFTNLLHEIFDIDVPVGVIVSPANDLQAL
TH_1879|M.thermoresistible__bu LERVGVDDSFFDLGGDSISAMRAVAAINTALDTDVAVRTLFEAP-TVRRL
MAB_2962|M.abscessus_ATCC_1997 SAELAADAHFTDLGGDSLSALSFSDLLRDIFAVEVPVGVIVSAANDLSGV
Mflv_2962|M.gilvum_PYR-GCK RAALGGRCHAAISGGAPLGAR--------LGHFYRGVGLSIYEGYGLTET
: ** .:.* * . :
Mvan_2578|M.vanbaalenii_PYR-1 ADYVE-----SARRHGSVRPTFESVHGHSGRPGTEVHARDLTLDEFVDAA
MSMEG_2956|M.smegmatis_MC2_155 AAYIE-----GELR-GSKRPTYASVH---GRDATEVRARDLALGKFIDAK
MLBr_00484|M.leprae_Br4923 ADYIE-----RER-QGTKRPTFIAIHGRD---AGKVHASDLTLDKFIDVS
MAV_3471|M.avium_104 ASYIE-----AER-QGSKRPTFASVHGRD---ATVVRAADLTLDKFLDAD
Mb2621|M.bovis_AF2122/97 ADHIE-----AAR-TGVRRPSFASIHGRS---ATEVHASDLTLDKFIDAA
Rv2590|M.tuberculosis_H37Rv ADHIE-----AAR-TGVRRPSFASIHGRS---ATEVHASDLTLDKFIDAA
MMAR_2117|M.marinum_M ADYVE-----AARKPGSSRPTFASVHGASNGQVTEVHAGDLSLDKFIDAA
MUL_1722|M.ulcerans_Agy99 ADYVE-----AARKPGSSRPTFASVHGASNEQVTEVHAGDLSLDKFIDAA
TH_1879|M.thermoresistible__bu SRQLEGGADTAPQGADLGAVTYESVHGAT---ATEVRAADLTLDRFIDAA
MAB_2962|M.abscessus_ATCC_1997 AKFVD-----EQRYSGGTRPTAETVHGAG---HTEIRAADLTLDKFIDEA
Mflv_2962|M.gilvum_PYR-GCK SAAIT-----------------------------VNRVGDLRVG-----S
: : :. ** :.
Mvan_2578|M.vanbaalenii_PYR-1 TLAHAPTLPGPRAEVRTVLLTGATGFLGRYLALEWLERMALVGGKLICLV
MSMEG_2956|M.smegmatis_MC2_155 TLSAAPGLPRSGTEIRTVLLTGATGFLGRYLALEWLERMDLVDGKVICLV
MLBr_00484|M.leprae_Br4923 TLTAAPVLAQPGTEVRTVLLTGATGFLGRYLALKWLERMDLVEGKVIALV
MAV_3471|M.avium_104 TLASAPNLPKPATEVRTVLLTGATGFLGRYLALEWLERMDMVDGKVIALV
Mb2621|M.bovis_AF2122/97 TLAAAPNLPAPSAQVRTVLLTGATGFLGRYLALEWLDRMDLVNGKLICLV
Rv2590|M.tuberculosis_H37Rv TLAAAPNLPAPSAQVRTVLLTGATGFLGRYLALEWLDRMDLVNGKLICLV
MMAR_2117|M.marinum_M TLAEAPRLPAANTQVRTVLLTGATGFLGRYLALEWLERMDLVDGKLICLV
MUL_1722|M.ulcerans_Agy99 TLAEAPRLPAANTQVRTVLLTGATGFLGRYLALEWLERMDLVDGKLICLV
TH_1879|M.thermoresistible__bu TLRTAADLPRPTGQVQTVLLTGATGFLGRYLLLEWLRRLRRVDDTVICLV
MAB_2962|M.abscessus_ATCC_1997 TLHAAPSLPKAVGIPHTVLLTGSNGYLGHYLALEWLERLDKTEGKLIAIV
Mflv_2962|M.gilvum_PYR-GCK VGKLVPGNSMRLGEDGELLVRGGVVFNG-YWGNEEETRAVFTDGWFHTGD
. .. . :*: *. : * * : * . . .
Mvan_2578|M.vanbaalenii_PYR-1 RAKDDAAARVRLDSTFDSGDPELLRHYRRLAADHLEVIAGDKADADLGLD
MSMEG_2956|M.smegmatis_MC2_155 RARSDDEARARLDATFDTGDATLLEHYRALAADHLEVIAGDKGEADLGLD
MLBr_00484|M.leprae_Br4923 RAKSNEDARARLDKTFDSGDPKLLAHYQELATDHLEVIAGDKGEVDLELD
MAV_3471|M.avium_104 RARSDEEARARLDKTFDSGDPKLLAHYQQLAADHLEVIAGDKGEANLGLR
Mb2621|M.bovis_AF2122/97 RARSDEEAQARLDATFDSGDPYLVRHYRELGAGRLEVLAGDKGEADLGLD
Rv2590|M.tuberculosis_H37Rv RARSDEEAQARLDATFDSGDPYLVRHYRELGAGRLEVLAGDKGEADLGLD
MMAR_2117|M.marinum_M RAKSDTEARARLDKTFDSGDPELLAHYRALAGDHLEVLAGDKGEADLGLD
MUL_1722|M.ulcerans_Agy99 RAKSDTEARARLEKTFDSGAPELLAHYRALAGDHLEVLAGDKGEADLGLD
TH_1879|M.thermoresistible__bu RGRSDADARQRLEAVFDT-DPALRRHFRELAAERLQVIAGDKGQPNLGLD
MAB_2962|M.abscessus_ATCC_1997 RGKNAEAAYRRLEEAFDTGDTQLLAHFRSLADKHLEVLAGDIGDPNLGLD
Mflv_2962|M.gilvum_PYR-GCK LGAIDDDG------------------FLTIVGRKKEIIVTAGGKN-----
. . : : : :::. ..
Mvan_2578|M.vanbaalenii_PYR-1 ARTWQRLADTVDLIVDPAALVNHVLPYRQLFAPNVLGTAELLRIALTTRM
MSMEG_2956|M.smegmatis_MC2_155 HDTWQRLADTVDLIVDPAALVNHVLPYSQMFGPNALGTAELIRIALTTTI
MLBr_00484|M.leprae_Br4923 RQTWRRLADTVDLIVDPAALVNHVLPYSELFGPNTLGTAELIRIALTSKQ
MAV_3471|M.avium_104 QDVWQRLADTVDVIVDPAALVNHVLPYSELFGPNALGTAELIRLALTSKQ
Mb2621|M.bovis_AF2122/97 RVTWQRLADTVDLIVDPAALVNHVLPYSQLFGPNAAGTAELLRLALTGKR
Rv2590|M.tuberculosis_H37Rv RVTWQRLADTVDLIVDPAALVNHVLPYSQLFGPNAAGTAELLRLALTGKR
MMAR_2117|M.marinum_M RQTWQRLADTVDLIVDPAALVNHVLPYSQLFGPNALGTAELLRLALTSKI
MUL_1722|M.ulcerans_Agy99 RQTWQRLADTVDLIVDPAALVNHVLPYSQLFGPNALGTAELLRLALTSKI
TH_1879|M.thermoresistible__bu VQTWRRLAERVDLIVDSAAFVNSVLPYRELFGPNVVGTAELIRFALTAKL
MAB_2962|M.abscessus_ATCC_1997 ADTWQRLADTVDVIVHPAALVNHVLPYSQLFGPNVVGTAEIIKLAITTKI
Mflv_2962|M.gilvum_PYR-GCK --------------VAPAQLEDRLRAHPLISQAMAVGDQQPFIAALIT--
* .* : : : .: : . . * : : *:
Mvan_2578|M.vanbaalenii_PYR-1 KPFVYVSTIGVGAGIEPARFTEDADIRQISATRRIDDSYANGYGNSKWAG
MSMEG_2956|M.smegmatis_MC2_155 KPYVYVSTIGVGQGISPEAFVEDADIREISATRRVDDSYANGYGNSKWAG
MLBr_00484|M.leprae_Br4923 KPYIYVSTIGVGNQIEPAKFTEDSDIRVISPTRNINNNYANGYGNSKWAG
MAV_3471|M.avium_104 KPYTYVSTIGVGDQIEPGKFVENADIRQMSATRAINDSYANGYGNSKWAG
Mb2621|M.bovis_AF2122/97 KPYIYTSTIAVGEQIPPEAFTEDADIRAISPTRRIDDSYANGYANSKWAG
Rv2590|M.tuberculosis_H37Rv KPYIYTSTIAVGEQIPPEAFTEDADIRAISPTRRIDDSYANGYANSKWAG
MMAR_2117|M.marinum_M KPYSYTSTIGVADQIPPSAFTEDADIRVISATRAVDDSYANGYSNSKWAG
MUL_1722|M.ulcerans_Agy99 KPYSYTSTIGVADQIPPSAFTEDADIRVISATRAVDDSYANGYSNSKWAG
TH_1879|M.thermoresistible__bu KPYNFVSTSDIGRQIEPDLFTEDADIRTISPTRTVDASYANGYGNSKWAG
MAB_2962|M.abscessus_ATCC_1997 KPVTYLSTVAVAAYVDPTTFDEESDIRLISAVRPVDELYANGYGNSKWAG
Mflv_2962|M.gilvum_PYR-GCK --------------VDTEAFPGWKERHHKASDASVADLADD---------
: . * : : :. : :
Mvan_2578|M.vanbaalenii_PYR-1 EVLLREAHDLCGLPVSVFRCDMILADTTYAGQLNLPDMFTRLIFSLVATG
MSMEG_2956|M.smegmatis_MC2_155 EVLLREAHDWCGLPVSVFRCDMILADTTYSGQLNLPDMFTRLMLSLVATG
MLBr_00484|M.leprae_Br4923 EVLLREAHDLCGLPVTVFRCDMILADTSYAGQLNVPDMFTRMMLSLAATG
MAV_3471|M.avium_104 EVLLREAHDLCGLPVAVFRCDMILADTTYAGQLNLPDMFTRLMLSLVATG
Mb2621|M.bovis_AF2122/97 EVLLREAHEQCGLPVTVFRCDMILADTSYTGQLNLPDMFTRLMLSLAATG
Rv2590|M.tuberculosis_H37Rv EVLLREAHEQCGLPVTVFRCDMILADTSYTGQLNLPDMFTRLMLSLAATG
MMAR_2117|M.marinum_M EVLLREAHDLCGLPVAVFRCDMILADTTWAGQLNVPDMFTRMILSLAATG
MUL_1722|M.ulcerans_Agy99 EVLLREAHVLCGLPVAVFRCDMILADTTWAGQLNVPDMFTRMILSLAATG
TH_1879|M.thermoresistible__bu EVLLREAHDLCGLPVAVFRSGMILVDPTYAGQLNVTDTVSRMVLSIVATG
MAB_2962|M.abscessus_ATCC_1997 EVLLREAHDLCGLPVAVFRSDMILAHSRYTGQLNVPDQFTRLILSLIATG
Mflv_2962|M.gilvum_PYR-GCK -----------------------------------PDLLAEIELAVKDAN
.* .:.: ::: :.
Mvan_2578|M.vanbaalenii_PYR-1 VAPESFYHLATDGTRQRAHYDGLPVEFIAEAISTLGSD---VASG-----
MSMEG_2956|M.smegmatis_MC2_155 IAPGSFYELDADGNRQRAHYDGLPVEFIAEAISTIGSQ---VTDG-----
MLBr_00484|M.leprae_Br4923 IAPGSFYELDAESNRQRAHYDGLPVEFIAEAISTLGDQSLHDRDG-----
MAV_3471|M.avium_104 IAPGSFYELDADGNRQRAHYDGLPVEFIAAAISTLGSQITDSDTG-----
Mb2621|M.bovis_AF2122/97 IAPGSFYELDAHGNRQRAHYDGLPVEFVAEAICTLGTH---SPDR-----
Rv2590|M.tuberculosis_H37Rv IAPGSFYELDAHGNRQRAHYDGLPVEFVAEAICTLGTH---SPDR-----
MMAR_2117|M.marinum_M IAPGSFYELAADGARQRAHYDGLPVEFIAEAISTLGAQ---SQDG-----
MUL_1722|M.ulcerans_Agy99 IAPGSFYELAADGARQRAHYDGLPVEFIAEAISTLGAQ---SQDG-----
TH_1879|M.thermoresistible__bu VAPKSFYRLGDDGSRQRAHFDGLPVDFVAEAVATLGWQIARTATGSPAGD
MAB_2962|M.abscessus_ATCC_1997 IAPGSFYQAHATGERPLAHYDGLPGDFTAEAITTLGTQ---VVDS-----
Mflv_2962|M.gilvum_PYR-GCK QAVS----------------------------------------------
*
Mvan_2578|M.vanbaalenii_PYR-1 FRTYHVMNPHDDGIGLDEYVDWLID----AGHPIRRVGDYPTWLQRFTVA
MSMEG_2956|M.smegmatis_MC2_155 FETFHVMNPYDDGIGLDEYVDWLIE----AGYPVHRVDDYATWLSRFETA
MLBr_00484|M.leprae_Br4923 FTTYHVMNPHDDGIGMDEFVDWLID----AGCPIQRINDYDEWLRRFEIS
MAV_3471|M.avium_104 FQTYHVMNPYDDGIGLDEYVDWLVD----AGYSIERIADYSEWLRRFETS
Mb2621|M.bovis_AF2122/97 FVTYHVMNPYDDGIGLDEFVDWLNSPTSGSGCTIQRIADYGEWLQRFETS
Rv2590|M.tuberculosis_H37Rv FVTYHVMNPYDDGIGLDEFVDWLNSPTSGSGCTIQRIADYGEWLQRFETS
MMAR_2117|M.marinum_M FHTYHVMNPYDDGIGLDEFVDWLNE----SGCPIQRIADYGDWLQRFETA
MUL_1722|M.ulcerans_Agy99 FHTYHVMNPYDDGIGLDEFVDWLNE----SGCPIQRIADYGDWLQRFETA
TH_1879|M.thermoresistible__bu FRTYHVMNPHDDGIGIDEYVDWLIE----AGHPIERIDDFGEWLRRFEAG
MAB_2962|M.abscessus_ATCC_1997 YETYDCVNPHADGVSLDNFVDWLIE----AGYPIARIDNYTEWFTRFDTA
Mflv_2962|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2578|M.vanbaalenii_PYR-1 ITALPERQRQASLLPLLHNYQH------PETPIRGSIAPTDRFREAVQDA
MSMEG_2956|M.smegmatis_MC2_155 LRALPERQRQASLLPLLHNYQQ------PSPPVCGAMAPTDRFRAAVQDA
MLBr_00484|M.leprae_Br4923 LRALPERQRHSSLLPLLHNYQK------PEKPLHGSLAPTIRFRTAVQNA
MAV_3471|M.avium_104 LRALPDRQRQYSLLPLLHNYRT------PEKPINGSIAPTDVFRAAVQEA
Mb2621|M.bovis_AF2122/97 LRALPDRQRHTSLLPLLHNYRE------PAKPICGSIAPTDQFRAAVQEA
Rv2590|M.tuberculosis_H37Rv LRALPDRQRHASLLPLLHNYRE------PAKPICGSIAPTDQFRAAVQEA
MMAR_2117|M.marinum_M LRALPDRQRHSSLLPLLHNYRQ------PERPVRGSIAPTDRFRAAVQEA
MUL_1722|M.ulcerans_Agy99 LRALPDRQRHSSLLPLLHNYRQ------PERPVRGSIAPTDRFRAAVQEA
TH_1879|M.thermoresistible__bu LHALPERQRQHSVLQMLTLLRQQGGEPQPPEPRHGSDAPADRFEAAVKRA
MAB_2962|M.abscessus_ATCC_1997 IRSLPEKQKQHSLLPLLHAFEQ------PSAAENHGVVPAKRFQHAVQAA
Mflv_2962|M.gilvum_PYR-GCK ---KAEAIRKFRILPVDFTEDT------------GELTPTLKVKRKVVAE
.: :: :* : .*: .. *
Mvan_2578|M.vanbaalenii_PYR-1 KIGPD-----KDIPHVTPQIVIKYVTDLQRLGLL
MSMEG_2956|M.smegmatis_MC2_155 KIGPD-----KDIPHVTADVIVKYISNLQMLGLL
MLBr_00484|M.leprae_Br4923 NIGQD-----KDIPHISPAIIAKYVSDLQLLGLV
MAV_3471|M.avium_104 KIGPD-----KDIPHVSPPVIVKYITDLQLLGLL
Mb2621|M.bovis_AF2122/97 KIGPD-----KDIPHLTAAIIAKYISNLRLLGLL
Rv2590|M.tuberculosis_H37Rv KIGPD-----KDIPHLTAAIIAKYISNLRLLGLL
MMAR_2117|M.marinum_M KIGPD-----KDIPHVGAPIIVKYVSDLRLLGLL
MUL_1722|M.ulcerans_Agy99 KIGPD-----KDIPHVGAPIIVKYVSDLRLLGLL
TH_1879|M.thermoresistible__bu GINGG-----QGIPHVTPEVIVRYVTDLRQLGLL
MAB_2962|M.abscessus_ATCC_1997 GIGPAGQDGTTDIPHLSRRLIVKYAKDLEQLGLL
Mflv_2962|M.gilvum_PYR-GCK KFAAD--------------IEALYAKG-------
: : * ..