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MEPVDGALPLSRGQLDIWLSHESGLAGAEWQLGLLGKIDGVVDHGLLQQAIRQALQEAEPARATFFEADG QVFQKPLDYSELEVPLYDVRDADDPEAKAREMAAEIQHTPLPLTGRLVKFALFQTRDEQFYLFGLGHHIS VDGLGMALVSRRISTIYTSLVTGKPVPEAYFGSLRDLVECEMSYESSADYQDDLAYWSENLPPDTGLDQG LAPTPHGKNAYTPSASVPMDPAIVGRIKELSKTLRIRRYSVTTAACALLAQSWSSTGDQVALDFPVSRRV SPESKTLPAMLAGVAPLVLDAPPQLTVGEFCKHVDIRIRELLQHQRFPVHRLGDGGALRGPRQASNRLAV NFIPSRLTLDFAGAEATASYTNHGPMGHFGLFFIGAGEELFLSTAGAGQPFANFEVPELAERLGAIVAAM AADPAMPLAAVRLLAESESDRLATIGNHSALSESAPDAVSIPERFAARVAEAPDAAALTFEGRTLTYREL DEAANRFAHALLARGIGPGSRVALMSPRTDRSVIAILGAFKAGAAYVPVDPAVPAARVRFILDDASPVAV VTTAELRSRFDGHDLAVIDIDDPAIASLPATAVSDPRPDDIAYVIYTSGTTGTPKGVAVTHKNLTHLIAV LEERLPKPGVWPLCHSLAFDASVWEISNALLRGGRLVVVPEAVAGSPEDFHDLLVAEQVTFLTQTPSAVA MLSPDGLESMTLAVVGEACPPALVDRWATNRTMINAYGPTETTICVTSSSPLEPGSVVVPIGSALPRTAL FVLDPWLRPVPTGVAGELYVAGDGVTCGYIGRSGLTASRFVPCPFGEPGARMYRTGDLVRWGRDGQLEYL GRADEQVKIRGYRIELGEVQSALAALDGVESAAAIMREDRPGDRRLVGYITGTADPVDIRAELADRLPPY MVPTAIVVLPALPLTSSNKLDTRALPAPEYANAEKNYRAPSNPVEEVLADIYAQVLGVERIGVDDSFFDL GGDSILSMQVVARARAAGIQCRPRDVFVEQTVARLASVATVATEIGVVDDGTGSAAPTPIIHWLREAGGA TDEFNQTLVVQAPTGVTEPDVVAVLQALLDRHATLRLRVQDSDGEWSLLVPDAATVDARDCLSVVDTLSD DVVLAARAKLNPAAGAMVSALWVRQTSQLVLIIHHLAVDGVSWRILLEDLNIAWAQHHSGQQVQLPAGGT SFLRWSKRLADHAHTAEVTAQADAWREILAKPAALPAVQPDTDTHASAGRFSATLDPETTRQLLGEVPAA FHAGVQDILLVAFGLAWAEFLNRSGTPITVDVEGHGRHEELASDIDLSRTVGWFTTKYPVALTVADVPWA QVVAGEATLGAVVKDVKEQLRAVPDGLTYGLLRYLNSEVELGGTEPTIGFNYLGRLGAGAGELSEELWRI EQGSLALTDVVSAVPMPLAHTVELNAGTMDTDKGPSLQASWTWAPSVFDEDKAARLSQLWFEALAGICAH VQAGGGGLTPSDIAPARLTQREIDQLTTQFEVADVLPLTPLQQGLLFQAGFAEAAGAEAAGVPSDDVYAV QLGITLSGSLDPQQLRDAVQAVIRRHPNLAARFVEQFGEPVQVLSVDPEIGWQFVEFDSGDTGVDERVER LCAAERSAVCKLGEQPVFRAALIRTADNLHRFVLTIHHIVIDGWSLPVLLQEIFAAYFDQSLPSAAPYRN FVTWLGAQDRDAAQAAWGSVLEGFETPTLVAPPAQAGPRGVESFRLSEATTRTLGELARSQHTTVNTVLQ AAWAQLLMWMTGQRDVVFGTAVSGRPVDLAGADSMVGLLINTVPVRATSGVATTVTDLLGQLQRDHNDTV DHEHMALNEIHRLTGHDRLFDTLFVYENYPIDANALLSVQDLAVTDFASREYNHYPLSMVATPGHEVVLR VEFDTEIFDAASIEALVDRLRRVLDAMATDPGRRLSTIDLLDPQEHDRLDEWGNRAVLTRPAPALESIPA SFAESVRRVPDAVALSCGDRSWTYRELDEASNRMAHLLAGRGAKPGERVAMLLPRTGEAVVTILAILKTG AAYLPIDPAHPDARIEFVLKDAAPVAAVSSADLCTRLIASGVPVIEVDDPAIGAEASTSLPVPAVDDIAY IIYTSGTTGTPKGVAVTHRNVAQLLDTLGAQLELGQTWTQCHSLAFDYSVWEIWGPLLNGGRLLMVPDAV VRSPEDLHAMLVAEQVSMLSQTPSAFYALQTADALYPERGEQLKLQTVVFGGEALEPHRLSGWMHAHPGM PRMINMYGITETTVHASFREIGEADLANSTSPIGVPLEHLSFFVLDGWLRQVPVGVVGELYVAGEGLACG YISRSDLTSTRFVACPFGAPGARMYRTGDLVRWGADGQLQYVGRADEQVKIRGYRIELGEVHAALVGLDG VEQAAVIAREDRPATSGWSVMSPARSTRSRPGPRSPSGSPRTWCPRRSW
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. smegmatis MC2 155 | MSMEG_0400 | - | - | 100% (2429) | peptide synthetase |
M. smegmatis MC2 155 | MSMEG_0402 | - | 0.0 | 66.20% (1982) | linear gramicidin synthetase subunit D |
M. smegmatis MC2 155 | MSMEG_3715 | - | 0.0 | 57.35% (1993) | linear gramicidin synthetase subunit C |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0104 | nrp | 0.0 | 43.57% (1035) | peptide synthetase |
M. gilvum PYR-GCK | Mflv_2697 | - | 1e-136 | 31.08% (1509) | amino acid adenylation domain-containing protein |
M. tuberculosis H37Rv | Rv0101 | nrp | 0.0 | 43.57% (1035) | peptide synthetase |
M. leprae Br4923 | MLBr_02353 | - | 6e-36 | 27.51% (469) | polyketide synthase |
M. abscessus ATCC 19977 | MAB_4099c | - | 0.0 | 69.91% (2413) | non-ribosomal peptide synthetase |
M. marinum M | MMAR_2518 | - | 0.0 | 50.35% (2433) | non-ribosomal peptide synthetase |
M. avium 104 | MAV_3244 | - | 0.0 | 67.06% (2395) | linear gramicidin synthetase subunit D |
M. thermoresistible (build 8) | TH_3730 | - | 0.0 | 61.80% (1864) | PUTATIVE linear gramicidin synthetase subunit D |
M. ulcerans Agy99 | MUL_2638 | - | 0.0 | 29.98% (2055) | peptide synthetase Nrp (peptide synthase) |
M. vanbaalenii PYR-1 | Mvan_3844 | - | 1e-154 | 32.16% (1539) | amino acid adenylation domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment Mb0104|M.bovis_AF2122/97 -------------------MHRVRLSRSQRNLYNGVRQDNNPALYLIGKS Rv0101|M.tuberculosis_H37Rv -------------------MHRVRLSRSQRNLYNGVRQDNNPALYLIGKS MSMEG_0400|M.smegmatis_MC2_155 ---------------MEPVDGALPLSRGQLDIWLSHESGLAGAEWQLGLL MAB_4099c|M.abscessus_ATCC_199 --------------MLESEDRALPLSRGQLDIWLSQETGLVGAEWQLGLL MAV_3244|M.avium_104 ---------------MARDDRAFPLTRGQLDIWLSQEAGFAGTQWQLGLL TH_3730|M.thermoresistible__bu -------------------------------------------------- MMAR_2518|M.marinum_M MTVDHHQILRDSGRALEPAESGFALTRGQLDIWFSQEIGRSPQEWYNSGF Mflv_2697|M.gilvum_PYR-GCK --------MTAAKTGAIADVMALSPLQQGLYSLTAMSDG--DDPYLIGMS Mvan_3844|M.vanbaalenii_PYR-1 ----MTQIQQSVEPPVIEDVLALSPLQQGLFSMATLSEGRDDDPYVIAMT MUL_2638|M.ulcerans_Agy99 -MTAGTPTVSQCPGEDDGDQAARWVAASASLTLDRSLHELADAGHFGHIS MLBr_02353|M.leprae_Br4923 ------------------------------------MITPDNAIAVVGMA Mb0104|M.bovis_AF2122/97 YRFRRLELARFLAALHATVLDN--PVQLCVLENSGADYPDLVPRLRFGDI Rv0101|M.tuberculosis_H37Rv YRFRRLELARFLAALHATVLDN--PVQLCVLENSGADYPDLVPRLRFGDI MSMEG_0400|M.smegmatis_MC2_155 GKIDGVVDHGLLQQAIRQALQEAEPARATFFEADGQVFQKPLDYSELEVP MAB_4099c|M.abscessus_ATCC_199 VRIEGQVERVLLERAIRQAVTEAEPARAAFFEVDGQIVQRPIDHSDLELA MAV_3244|M.avium_104 VKIDGKVHRDALEQAITQAVAEAEPGRVSFFEVDGQVVQKPIDYPHVELA TH_3730|M.thermoresistible__bu -------------------------------------------------- MMAR_2518|M.marinum_M AVIAGSVTPDLLSQAIRQVVGEAEPLRAAIIEADGHVVQKVVDYPNLDVP Mflv_2697|M.gilvum_PYR-GCK ADITGALDVSLLHDCAAAVLARHPNLRAGFFQGDLKRPVQVIP-EKVEVL Mvan_3844|M.vanbaalenii_PYR-1 ADATGDLDARLLRECAAELLDRHANLRASFVKGNLSRAVQVIP-KRVDLP MUL_2638|M.ulcerans_Agy99 AGADGSAVDLAELSAIVERVGGIDVGHAALLAVHHGAMQTVLLHGSSQAR MLBr_02353|M.leprae_Br4923 GKFPGANDVSAFWTNLRRGKESIVTLSEQELRDNGVSDKALADPAYVR-- Mb0104|M.bovis_AF2122/97 VR--------VGSADEHLQSTWCSGILGKPLVRHTVHTDPNGYVTGLDVH Rv0101|M.tuberculosis_H37Rv VR--------VGSADEHLQSTWCSGILGKPLVRHTVHTDPNGYVTGLDVH MSMEG_0400|M.smegmatis_MC2_155 LYDVRDADDPEAKAREMAAEIQHTPLPLTGRLVKFALFQTRDEQFYLFGL MAB_4099c|M.abscessus_ATCC_199 FEDLRDSDDPAGLARKKATDIQRTLMPLTGQLLKFALYRTADDEFHLFGL MAV_3244|M.avium_104 FHDLTDHADPVAEAREMSSAIQRTPMPLNGQMFKFVLFQTGHDEFYLFGC TH_3730|M.thermoresistible__bu -------------------------------------------------- MMAR_2518|M.marinum_M FHDLRSCADPVAEANRRGLAMHREPMPWNGPLFKFALFQVASEEFYLFVS Mflv_2697|M.gilvum_PYR-GCK WRHVRCDG-TEVEPLEREERARRFDLGR-GPAMRFLLLETGQQRWRFVIT Mvan_3844|M.vanbaalenii_PYR-1 WRHVTVAGDAELEAAERLERTTPFTLAR-GPVIRFLLIEAP-QRWRFVVT MUL_2638|M.ulcerans_Agy99 QRFIG-----PMRTARLLGSLAIIEPSVSGSNLRELVSTAIPDGSDWVIS MLBr_02353|M.leprae_Br4923 -------------RAPLLDGIDEFDADFFGLPPLAAQVLDPQHRLFLQCA Mb0104|M.bovis_AF2122/97 THHILLDGGATGTIEADLARYLTTDPAGETPSVGAGLAKLREAHRRETAK Rv0101|M.tuberculosis_H37Rv THHILLDGGATGTIEADLARYLTTDPAGETPSVGAGLAKLREAHRRETAK MSMEG_0400|M.smegmatis_MC2_155 GHHISVDGLGMALVSRRISTIYTSLVTGKPVPE-AYFGSLRDLVECEMSY MAB_4099c|M.abscessus_ATCC_199 CHHINLDGLGMAVVSRRVASIYTALATGEPIPP-AYFGTLQDLVDWETDY MAV_3244|M.avium_104 CHHIAIDGLGMALVCRRVATIYSAMVAGKPIPD-AYFGTVQDLIDLESGY TH_3730|M.thermoresistible__bu -------------------------------------------------- MMAR_2518|M.marinum_M IHHVVVDGFGYALLVNRIALVYSELSSGAPVSP-TFFGSLQTLVAAEAEY Mflv_2697|M.gilvum_PYR-GCK AHHIVIDGWSLSLLVSELLALYRAAGNTSALPD-APR-----PYRDYIGW Mvan_3844|M.vanbaalenii_PYR-1 AHHILIDGWSLPLFMGELLTLYRAGGDVTALPD-PPR-----PYRDYIGW MUL_2638|M.ulcerans_Agy99 AAKSCITGAGCTGVFVTLVPFAVDGGIALTAVAIPADSPGVSVLPPERTF MLBr_02353|M.leprae_Br4923 WHALEDAGCDPAQFDGSIGVYGTSSPSGYLLHN--------LLSHRDPHT Mb0104|M.bovis_AF2122/97 VEESRGRLSAVVQRELADEAYHGGHGHSVSDAPGTAAKGVLHESATICGN Rv0101|M.tuberculosis_H37Rv VEESRGRLSAVVQRELADEAYHGGHGHSVSDAPGTAAKGVLHESATICGN MSMEG_0400|M.smegmatis_MC2_155 ESSADYQDDLAYWSENLPPDTGLDQGLAPTPHGKNAYTPS--ASVPMDPA MAB_4099c|M.abscessus_ATCC_199 VASAEYAEDREYWSNNLPPDSGLDYRMPHASEESDGYKPS--DSVQMDDV MAV_3244|M.avium_104 EASPDYAEDKAYWSEHLPPESGPVDRLPDAEGERDHYSPS--ASVQLDPS TH_3730|M.thermoresistible__bu -------------------------------------------------- MMAR_2518|M.marinum_M EQSDDYRADLAYWKETLDGVT--DHSLAHADGDRGPSATS--VSVEIDPA Mflv_2697|M.gilvum_PYR-GCK LAARDQDHARSLWRAHLADLDGPTLLAPALGAATIGDGLPGMVELTADPS Mvan_3844|M.vanbaalenii_PYR-1 LAGRDEETGRALWRRHLAGVDGPTLLTPALTSSAPTPGRPRLTEVRLDAE MUL_2638|M.ulcerans_Agy99 GLRSVPVSGIRFDGVRVAPWQILGGIGDGLEVIDQGLRIGRASAGAIGLG MLBr_02353|M.leprae_Br4923 VLAEGLNFDQFSLFLQNDKDFLATRISHAFNLRGPSIAVQTACSSSLVAL Mb0104|M.bovis_AF2122/97 AFDAILTLSEAQRVPLNVLVAAAAVAVDASLRQNTETLLVHTVDNRFGDS Rv0101|M.tuberculosis_H37Rv AFDAILTLSEAQRVPLNVLVAAAAVAVDASLRQNTETLLVHTVDNRFGDS MSMEG_0400|M.smegmatis_MC2_155 IVGRIKELSKTLRIRRYSVTTAACALLAQSWSSTGDQVALDFPVSR-RVS MAB_4099c|M.abscessus_ATCC_199 TVSEIKELTKVLRIRRYSVITAACALLVRGWSTSGSEVALDFPVSR-RVH MAV_3244|M.avium_104 VANRIKELSKKLAIRRFSVTTAACALLVRGWSGSGSEVALDFPVSR-RVR TH_3730|M.thermoresistible__bu -------------------------------------------------- MMAR_2518|M.marinum_M VVDRAEQLAQLAGVRRSSVITAACALMVRQRQG-GPKVVLDFPVSR-RTS Mflv_2697|M.gilvum_PYR-GCK ITEAVVDAARARGVTVNSLVQLAWALTLSSLTDRDDITFGVTVSGRPDDL Mvan_3844|M.vanbaalenii_PYR-1 TTRQLAEAARSRGVTMNTLIQMAWATVLSVITDRTDVSFGVTVSGRPGEL MUL_2638|M.ulcerans_Agy99 VMKRCAQLIYRFASQREVSTGLLITDPVVQRRTARIAAEIESIEALLGVV MLBr_02353|M.leprae_Br4923 HLACLSLLSGECDMALAGGSSLCIPHRVGYWHSPGSMVSAVGHCRPFDVR Mb0104|M.bovis_AF2122/97 D--LNVATCLVNSVAQTVRFPPFASVSDVVRTLDRG--------YVKAVR Rv0101|M.tuberculosis_H37Rv D--LNVATCLVNSVAQTVRFPPFASVSDVVRTLDRG--------YVKAVR MSMEG_0400|M.smegmatis_MC2_155 PESKTLPAMLAGVAPLVLDAPPQLTVGEFCKHVDIR--------IRELLQ MAB_4099c|M.abscessus_ATCC_199 PDSRTLPGMMAGVVPLVLNAPPQSTVAEFCRHVDTR--------IRELLQ MAV_3244|M.avium_104 PESKTLPAMLAGVVPLVLSTAPESTVADFCKHVDKR--------IRELLA TH_3730|M.thermoresistible__bu -------------------------------------------------- MMAR_2518|M.marinum_M PQLMTIPGMLSGTVPLVLTVPPDAEVNAFCQHVESQ--------IKQAVR Mflv_2697|M.gilvum_PYR-GCK AGVESMIGLFVNTVPLRVRLDPALTAGAQCRALQQD--------AATLRD Mvan_3844|M.vanbaalenii_PYR-1 AGVERMVGLFINTVPLRVRLDPAAPAGEQCLALQRE--------AAALRD MUL_2638|M.ulcerans_Agy99 ATEPDTPQEIFLTLKVAASEFAYHATDNAMQTLGWRGYVKRNRVAALMRD MLBr_02353|M.leprae_Br4923 ADGTVFGSGVALVALKPLQAAIDASDRIHAVILGSAIN-------NDGSM Mb0104|M.bovis_AF2122/97 RRWLREEHYRRMYLAINRTSHVEALTLNFIREPCAPGLRPFLSEVPIATD Rv0101|M.tuberculosis_H37Rv RRWLREEHYRRMYLAINRTSHVEALTLNFIREPCAPGLRPFLSEVPIATD MSMEG_0400|M.smegmatis_MC2_155 HQRFPVHRLGDG---GALRGPRQASNRLAVNFIPSRLTLDFAGAEATASY MAB_4099c|M.abscessus_ATCC_199 HQRFPVHTLEDEE--FGLRGPRHAGNRVAVNFIPARLTLDLAGAPATASY MAV_3244|M.avium_104 HQRFPVHTLEGD-------GLRQAPNRVGINFIPSRLTLDLAGSPATASY TH_3730|M.thermoresistible__bu -------------------------------------------------- MMAR_2518|M.marinum_M HQRFPMHILESGA--YQQFNEKSAG-AVSVNFMPSVTLAPFGGAASTVTI Mflv_2697|M.gilvum_PYR-GCK HSYLGHAELRALAGVGELFDTLLVYENFPPGAVAGAGTLEAAGATFTPVA Mvan_3844|M.vanbaalenii_PYR-1 HGYLSHSELRALGGIGELFDTLLVYENFPPGGLVGQARFEANGATFVPSA MUL_2638|M.ulcerans_Agy99 VRFLRIGEGPSEALLTELGARLAARSDTVYDWMASRGSGRDAANRLREIV MLBr_02353|M.leprae_Br4923 KMGYAAPNPAAQADVIAEAHAVAGIDSSTVSYVETHGTGTPLGDPIEIQG Mb0104|M.bovis_AF2122/97 IGPVEGMTVA-------------SVLDEEQRTLNLAIWNRADLPACKTHP Rv0101|M.tuberculosis_H37Rv IGPVEGMTVA-------------SVLDEEQRTLNLAIWNRADLPACKTHP MSMEG_0400|M.smegmatis_MC2_155 TNHGPMGHFG-------------LFFIGAGEELFLSTAGAGQPFANFEVP MAB_4099c|M.abscessus_ATCC_199 TNHGPMGHFG-------------LFFIGASDQLVLSSSGDGEPFARFGVP MAV_3244|M.avium_104 TNHGPVGHFG-------------LFFLGAGDQLFLSTAGPGQPFASFGVA TH_3730|M.thermoresistible__bu -------------------------------------------------- MMAR_2518|M.marinum_M LSFAQGEQFG-------------MVFTKDGGRLFLHTVGSGGPFADLDVS Mflv_2697|M.gilvum_PYR-GCK LQSLAHFPVT-------------IAAHLTDGRLTVLVEAKDGALGQITPR Mvan_3844|M.vanbaalenii_PYR-1 LESLSHFPVT-------------IAAHLADDELTVFVEVIDGALGALRPG MUL_2638|M.ulcerans_Agy99 DELAADTSVNNFHDLGRLGGWAILAAVAPQGSATQALIERGWRFERTKVG MLBr_02353|M.leprae_Br4923 LKTAFEVSQIPRPG-------PCVLGSVKSNIGHLEVAAGIAGLIKTILC Mb0104|M.bovis_AF2122/97 KVAERIAAALESMAAMWDRPIAMIVN----------------DWFGIGPD Rv0101|M.tuberculosis_H37Rv KVAERIAAALESMAAMWDRPIAMIVN----------------DWFGIGPD MSMEG_0400|M.smegmatis_MC2_155 ELAERLGAIVAAMAADPAMPLAAVRLLAESESDRLATIGNHSALSESAPD MAB_4099c|M.abscessus_ATCC_199 NLAVRLQRLLSEMAADPDRRLSSLDSLVNDELADLAELGNRAILTAPAAR MAV_3244|M.avium_104 DLAGRLQQILAAMTEDPDRPLSSIELLTGDEPALIDRWSNRPALTEPAPA TH_3730|M.thermoresistible__bu -------------------------------------------------- MMAR_2518|M.marinum_M DLAARLQAVLTVMAAEPGRRLSLIDLLDPNEHERLDDWGNRAALTKAVPT Mflv_2697|M.gilvum_PYR-GCK ALGTRLLATVSRIVEGWDRPLREISISPDDHPVPVPVSEAAPTPSPSTGV Mvan_3844|M.vanbaalenii_PYR-1 DLGRRVLHTAQRLISCWDAPLRSVGVLLPAEHTPAPMVREPLTAN---SI MUL_2638|M.ulcerans_Agy99 GRNEHASGYEQALPAYADAVGTLDEFLAGDAEVDPALHPLRRREAEPIVG MLBr_02353|M.leprae_Br4923 LKNKAIPATLHYTSPNRELRLDQTPFVVQSNYGPWKWDGVRRAGVSSFGV Mb0104|M.bovis_AF2122/97 GTR------CQGDWPARQPSTP-AWFLDSAR-GVHQFLGRRRFVYPWVAW Rv0101|M.tuberculosis_H37Rv GTR------CQGDWPARQPSTP-AWFLDSAR-GVHQFLGRRRFVYPWVAW MSMEG_0400|M.smegmatis_MC2_155 AVS------IPERFAARVAEAPDAAALTFEG-RTLTYRELDEAANRFAHA MAB_4099c|M.abscessus_ATCC_199 PVS------IPELFTAQVSAEPDAVALTFGG-SSLTYRELDEAADRLAIQ MAV_3244|M.avium_104 PVS------IPQAFAEHVQRTPDAVAVTFGA-TSLTYAQLDEASNRLGHL TH_3730|M.thermoresistible__bu -------------------------------------------------- MMAR_2518|M.marinum_M PGS------LPALFAAQVARTPEATAITDGD-VSLTYAQLDAQSTQLAQA Mflv_2697|M.gilvum_PYR-GCK HTR------FTETASARLGSVALSWDGG-----ALTYRQLDEAADRLAAV Mvan_3844|M.vanbaalenii_PYR-1 HDR------FAGIAGDRLGSVALTWEAGGDS-GTLTYRQLDEAADRMAVA MUL_2638|M.ulcerans_Agy99 PRRPGGDHSIHELVAAQIERIPQAIAIEDVHGATVTYAELGERVDAFAEH MLBr_02353|M.leprae_Br4923 GGTN--VHVVLEEASVEASTVAASTGPQVILLSAQTAAALGESREALATV Mb0104|M.bovis_AF2122/97 LVQRGAAPGDVLVFTDDDTDKTIDLLIACHLAGCGYSVCDTADEISVRTN Rv0101|M.tuberculosis_H37Rv LVQRGAAPGDVLVFTDDDTDKTIDLLIACHLAGCGYSVCDTADEISVRTN MSMEG_0400|M.smegmatis_MC2_155 LLARGIGPGSRVALMSPRTDRSVIAILGAFKAGAAYVPVDPAVPAARVRF MAB_4099c|M.abscessus_ATCC_199 LGHRGVGPGDRVILFSDRSARAVIGILAVLKTGAAYLPVDPAVPASRLEF MAV_3244|M.avium_104 LADHGVGPGDCVAVMFPRCADAIVSMLAVLKTGAAYVPIDPAHASSRMDF TH_3730|M.thermoresistible__bu -------------------------------------------------- MMAR_2518|M.marinum_M LTALGARPGELIALLLPRTHRGIIAILAVLKTGAGYLPIDPMHPDTRIAF Mflv_2697|M.gilvum_PYR-GCK LTASGVRTETPVAVRLRRGADYVVAMFAVLKAGGAIVPLDPAMPADRIEV Mvan_3844|M.vanbaalenii_PYR-1 LTAAGVGPETSVAVLLSRGPDYVVTMLGVLKAGGVIVPLDPAMPAERISD MUL_2638|M.ulcerans_Agy99 LAAAGVRPGDAIGVFLGRSVHLAVAALAIARSG-VVVVVNPTHPSARVAD MLBr_02353|M.leprae_Br4923 LEKPGAPDLSDVAYTLAGRRKHNITMAAVVRDREHAVTVLRAAEHDNVFV Mb0104|M.bovis_AF2122/97 AITEHGDGILVTVVDVAATQLAVVGHDELRK-----VVDERVTQVTHDAL Rv0101|M.tuberculosis_H37Rv AITEHGDGILVTVVDVAATQLAVVGHDELRK-----VVDERVTQVTHDAL MSMEG_0400|M.smegmatis_MC2_155 ILDDASPVAVVTTAELRSRFDGHDLAVIDID---DPAIASLP-ATAVSDP MAB_4099c|M.abscessus_ATCC_199 IVSDAAPVAAITTTDLRGRLDGFGLAVIDLDAHTDSPAEGQS-GLVPAAP MAV_3244|M.avium_104 VLADAAPSAVITTSDLRSRLDDHDLLVIDVH---DPAVEAQP-GTALPWP TH_3730|M.thermoresistible__bu ----------VTTAELGARLHRSGVPVIHID---DPAAPGQAGATTGPAP MMAR_2518|M.marinum_M MLNDSTPIAAITTGALHPRLNDYDLPVIDIE---NPPTDTTP-ATNPPTP Mflv_2697|M.gilvum_PYR-GCK ILRRAGVTVVVDEDTVARAT------------------AEPPAQYRPAET Mvan_3844|M.vanbaalenii_PYR-1 ILEQSRASVVVDDAFVAAVPD-----------------VEPPAGYRPAEV MUL_2638|M.ulcerans_Agy99 MITDAGVSRVVVDDQTRPLVPVNAPELIAADR-----AGAAVASMPPPQL MLBr_02353|M.leprae_Br4923 GESGADTGRSAAASITTLGSDRVVFLFPGQG--------AQHVGMAKGLY Mb0104|M.bovis_AF2122/97 LATKTAYIMPTSGTTGQPKLVRISHGSLAVFCDAISRAYG----WGAHDT Rv0101|M.tuberculosis_H37Rv LATKTAYIMPTSGTTGQPKLVRISHGSLAVFCDAISRAYG----WGAHDT MSMEG_0400|M.smegmatis_MC2_155 RPDDIAYVIYTSGTTGTPKGVAVTHKNLTHLIAVLEER------LPKPGV MAB_4099c|M.abscessus_ATCC_199 APDDIAYIIYTSGTTGAPKGVAVTHHNVTQLMQSLDAG------LPKPGV MAV_3244|M.avium_104 APENTAYIIYTSGTTGTPKGVAIPHLNVTWLIESLDAG------LPPGNV TH_3730|M.thermoresistible__bu APDDIAYIIYTSGTTGVPKGVAVTHRNVAALLSALDAE------LASGQV MMAR_2518|M.marinum_M TPHDLAYIIYTSGSTGTPKGVGITHHNVTQLLNSFDPQST-AILFSPNRV Mflv_2697|M.gilvum_PYR-GCK LPGQAAYVVFTSGTTGEPKGVIGTHRALLAYADDHIGAILRPAADRVGRP Mvan_3844|M.vanbaalenii_PYR-1 TADRAAYIVFTSGTTGRPKGVVGTHGAVLGYAEDHAEQVLRPAAARIGRP MUL_2638|M.ulcerans_Agy99 DPAEPAYLNFTSGSTGRPKAVTSSHRAFCNQLLWRRDEFG----LGGDDA MLBr_02353|M.leprae_Br4923 DTESVFAEHFDTCSAGFREAMDDLDLHSAIFNGTAIDLERIDRSQPALFT . : ::* : : . Mb0104|M.bovis_AF2122/97 VLQCAPLTSDIS-VEEIFGGAACGARLVRSAAMKTGDLAALVDDLVARET Rv0101|M.tuberculosis_H37Rv VLQCAPLTSDIS-VEEIFGGAACGARLVRSAAMKTGDLAALVDDLVARET MSMEG_0400|M.smegmatis_MC2_155 WPLCHSLAFDAS-VWEISNALLRGGRLVVVPEAVAGSPEDFHDLLVAEQV MAB_4099c|M.abscessus_ATCC_199 WPLCHSLAFDVS-VWEIWGALLRGGRLAVVPESITASPADFHDLLVAEQV MAV_3244|M.avium_104 WTQCHSSAFDFS-VWEIFGALLRGRRLLVVPESVASSPEDFHALLVAEQV TH_3730|M.thermoresistible__bu WTQCHSLAFDFS-VWEIWGPLLYGGRVVIVPDPVVRSPEDLHALLAAEQV MMAR_2518|M.marinum_M WTQWHSYSFDVS-VWEIWGALLSGARLVVVPEHTAKSPDELLGLLVDERV Mflv_2697|M.gilvum_PYR-GCK LRIAHAWSFTFDAAWQPLAALLDGHSVHIVDDATQRDAEALVDTIARFGV Mvan_3844|M.vanbaalenii_PYR-1 LRVGHAWSFTFDAAWQPLAALLDGHSVHLLGEESQRDAEALVYRIGRFGI MUL_2638|M.ulcerans_Agy99 LLQTAAPTFDIF-MWEIFGPLVAGARLVFNPGE--WDPHSIVQRVRQSSI MLBr_02353|M.leprae_Br4923 VEYALAKLVESFGVGAGAYIGYSTGEYIAATLAGVFDLETAIKTVSLRAR . . : Mb0104|M.bovis_AF2122/97 TIVDLPTAVWQLLCADG-DAIDAIGRSRLRQIVIGGEAIRCSAVDKWLES Rv0101|M.tuberculosis_H37Rv TIVDLPTAVWQLLCADG-DAIDAIGRSRLRQIVIGGEAIRCSAVDKWLES MSMEG_0400|M.smegmatis_MC2_155 TFLTQTPSAVAMLSPDG---------LESMTLAVVGEACPPALVDRWAT- MAB_4099c|M.abscessus_ATCC_199 TVLTQTPSAVAMLSPDG---------LESTALAVVGEACPAAVVDKWAP- MAV_3244|M.avium_104 SVLTQTPSAVAMLSPEG---------LESTALVVAGEACPTDVVDRWAAP TH_3730|M.thermoresistible__bu GMLSQTPSAFYALQTADSLQPEQARQLQLQTVVFGGEALEPQRLSAWMRN MMAR_2518|M.marinum_M NVLSQTPSAFYALQAAAEASDELSSRLQLDAALFAGEALQPHRLTSWMSR Mflv_2697|M.gilvum_PYR-GCK DMIDTTPSMFARLRDVG-----LLSTVPLAVLALGGEAVDPGLWQQIRQE Mvan_3844|M.vanbaalenii_PYR-1 DMLDTTPSMFAQLHDVG-----LLSTVPLAVLALGGEAVSPATWRLIGDE MUL_2638|M.ulcerans_Agy99 TMLQIVPSQLDVLLEEP----DLGQCMTLRYVFCGGEPLSLALCRRFAAV MLBr_02353|M.leprae_Br4923 LMHESPPGAMVAVALGP-------EDITEYLAEYSAKGVELSAVNDPGNC . .. : .: Mb0104|M.bovis_AF2122/97 AASQGISLLSSYGPTEATVVATFLPIVCDQTT---------MDGALLRLG Rv0101|M.tuberculosis_H37Rv AASQGISLLSSYGPTEATVVATFLPIVCDQTT---------MDGALLRLG MSMEG_0400|M.smegmatis_MC2_155 ----NRTMINAYGPTETTICVTSSSPLEPGS--VVVPIGSALPRTALFVL MAB_4099c|M.abscessus_ATCC_199 ----GRTMINAYGPTETTMCVAISAPLKADLPDAVVPIGSPVPGAALFVL MAV_3244|M.avium_104 ----GRVMLDAYGPTETTVCASISTPLTAGDP--VVPIGSPIAGAAMFVL TH_3730|M.thermoresistible__bu HP-ERPRLINMYGITETTVHASFREIGAADLDDNTSPIGRPLPHLAFFVL MMAR_2518|M.marinum_M HP-RRPGLFNLYGTTETTVHASWREIVGSDTAADVSPIGTPLPSLGFFVL Mflv_2697|M.gilvum_PYR-GCK CARTGMSAFNCYGPTETTVEAVVAEIGAHERP----TIGRPTAPTRAYVL Mvan_3844|M.vanbaalenii_PYR-1 CARTGMTAFNCYGPTETTVEAVVAPIDGYQRP----SIGQPTRTMRTYVL MUL_2638|M.ulcerans_Agy99 LP--HAELVNLYGPTETTIDAIFWRVEVADEAS-WAPIGRPIANACLYVV MLBr_02353|M.leprae_Br4923 VVAGPKDQIRAFSQRLDEVGIPVRRVR-------------ATHAFHTSSM . :. : Mb0104|M.bovis_AF2122/97 RPILPNTVFLAFGEVVIVGDLVADGYLGIDGDGFGTVTAADGSR---RRA Rv0101|M.tuberculosis_H37Rv RPILPNTVFLAFGEVVIVGDLVADGYLGIDGDGFGTVTAADGSR---RRA MSMEG_0400|M.smegmatis_MC2_155 DPWLRPVPTGVAGELYVAGDGVTCGYIGRSGLTASRFVPCPFGE-PGARM MAB_4099c|M.abscessus_ATCC_199 DTWLQPVPAGVVGELYVAGDGVACGYVGRSDLTASRFVACPFGK-PGTRM MAV_3244|M.avium_104 DKWLQPVPAGVVGELYLAGRGVGHGYVRRPGLTASRFVPNPFGA-PGSRM TH_3730|M.thermoresistible__bu DGWLRPVPPGVVGELYVAGAGLATGYVSRSDLTSTRFVACPFGP-PGTRM MMAR_2518|M.marinum_M DGWLRPVPVGVVGELYVAGGGVGLGYWRRADLTGTRFVACPFGQTPGTRM Mflv_2697|M.gilvum_PYR-GCK DSWLRPVPSGAAGELYLAGGQLTRGYLGRPGETAARFVPDPFVP--GARM Mvan_3844|M.vanbaalenii_PYR-1 DAWLRPVPDGVAGELYLSGRQLTRGYLGRAAETAGRFVADPFTP--GQRM MUL_2638|M.ulcerans_Agy99 DPEGALAAPGGEGELWIGGAGVTMGYLGSPAITAQRFRRDVRCAHPGARV MLBr_02353|M.leprae_Br4923 EPMLREFSEFLSRQQLRVPNTPLLSNLTGTWMSEQQVTDPENWTRQISST : . . Mb0104|M.bovis_AF2122/97 FATGDRVTVDAEGFPVFSGRKDAVVKISGKRVDIAEVTRRIAEDPAVSDV Rv0101|M.tuberculosis_H37Rv FATGDRVTVDAEGFPVFSGRKDAVVKISGKRVDIAEVTRRIAEDPAVSDV MSMEG_0400|M.smegmatis_MC2_155 YRTGDLVRWGRDGQLEYLGRADEQVKIRGYRIELGEVQSALAALDGVESA MAB_4099c|M.abscessus_ATCC_199 YRTGDLVLWGDDGQLQYLGRADEQVKIRGYRIELGEVQAALGALDGVDQA MAV_3244|M.avium_104 YRTGDLVCWGPDGQLQYLGRADEQVKIRGFRIELGEIQSVLAGLDGVEQA TH_3730|M.thermoresistible__bu YRTGDLVRWDTGGELHYIGRADEQVKIRGYRIELGEIQAALARLDGVDQA MMAR_2518|M.marinum_M YRTGDLVWWGTDGQLRYLGRADNQVKIRGFRIEPCEVGAALSRMAGVDQA Mflv_2697|M.gilvum_PYR-GCK YRTGDVVRRAVDGTLAFLGRSDTQVKIRGFRVEPGEVAAVLRTHPAVGQA Mvan_3844|M.vanbaalenii_PYR-1 YRTGDVVRRGADGGLQFLGRADNQVKIRGFRVEPGEIAAVLSGHPAVTDA MUL_2638|M.ulcerans_Agy99 YRTGDRVRQRPDGTLEFLGRMDRQLKVHGVRIEPAEIERTLCEHPGVQHA MLBr_02353|M.leprae_Br4923 IRFADELDVVLSQSGRVLVEVGPGGSLTGSAMRHPRWSSGHRAVRLMRHP .* : . . .: * : . : Mb0104|M.bovis_AF2122/97 AVELHSGSLGVWFKSQRTREGE----QDAAAATRIRLVLVSLGVSSFFVV Rv0101|M.tuberculosis_H37Rv AVELHSGSLGVWFKSQRTREGE----QDAAAATRIRLVLVSLGVSSFFVV MSMEG_0400|M.smegmatis_MC2_155 AAIMREDRPGDRRLVGYITGT-----ADPVDIRAELADRLPPYMVPTAIV MAB_4099c|M.abscessus_ATCC_199 AAIVREDRPGDKRLVGYVTGT-----ADPAEIRGILSKRLPPYMVPAAVV MAV_3244|M.avium_104 AVVAREDRPGDKRLVGYITGT-----ADPAELRAQLADRLPPYMVPTAVM TH_3730|M.thermoresistible__bu AVIAREDRPGDKRLVGYITGT-----ADPVQARAQLADRLPPYMVPAAIV MMAR_2518|M.marinum_M VVIARHDHPGDPRLVGYFTGN-----ADPTELRAALATQLPHYMVPTALI Mflv_2697|M.gilvum_PYR-GCK YVAVRPHR-DGHRLTAYVTGE-----PQLRELRAWLGRRLPRYLMPNAIV Mvan_3844|M.vanbaalenii_PYR-1 HVVVDRVG-TQTRLIAYVAAATP---PAVADLRELMAKRLPRYMVPQRVV MUL_2638|M.ulcerans_Agy99 VVTVKERAPGDKALAAYLISDSPNMELDLEAVLKTCRTKLPATMVPAAVM MLBr_02353|M.leprae_Br4923 LQNVDDHDTFLRALGELWSAGIEVDWAPQRSVMPHLVSLPGYPFARQRHW . Mb0104|M.bovis_AF2122/97 GVPNIPRKPNGKIDSDNLPRLPQWSAAGLNTAETGQRAAGL--SQIWSRQ Rv0101|M.tuberculosis_H37Rv GVPNIPRKPNGKIDSDNLPRLPQWSAAGLNTAETGQRAAGL--SQIWSRQ MSMEG_0400|M.smegmatis_MC2_155 VLPALPLTSSNKLDTRALPAPEYANAEKNYRAPSNPVEEVL--ADIYAQV MAB_4099c|M.abscessus_ATCC_199 VLETLPLTSNNKLDTRALPAPEYGGLGADYRAPGNAVEEIL--AGVYAQV MAV_3244|M.avium_104 VLDALPLTGNGKLDKRALPSPEYAAG--EYRAPGDAIEEIL--ADIYAQV TH_3730|M.thermoresistible__bu VLESIPLTSNNKLDVRALPAPEYRATGAEYRAPGTPLEGLL--AGIFAEV MMAR_2518|M.marinum_M PIAELPLTVNGKLDTRALPAVQYGHT-QRYRAPDTPAEQTL--AAIYAQV Mflv_2697|M.gilvum_PYR-GCK AVDRIPLTAHGKIDEPALVALEPAADGAATRP-QTPTEVEL--AAVLAEV Mvan_3844|M.vanbaalenii_PYR-1 VLDELPLTSHGKIDEAALAGIA-VEDAPSAAP-ETPTETAL--VELMAEV MUL_2638|M.ulcerans_Agy99 VLDSLPRTSTGKVDMAALPAVPFAGAADADADVRDVPQRLIGLARIWEEI MLBr_02353|M.leprae_Br4923 VEPRYTIWAQIPGASSGSPVDSSVDSATVEGVRGGESQTEATLQRIWSQC . : . Mb0104|M.bovis_AF2122/97 LG-RAIGPDSSLLGEGIGSLDLIRILPETRRYLGWRLSLLDLIGADTAAN Rv0101|M.tuberculosis_H37Rv LG-RAIGPDSSLLGEGIGSLDLIRILPETRRYLGWRLSLLDLIGADTAAN MSMEG_0400|M.smegmatis_MC2_155 LGVERIGVDDSFFDLGGDSILSMQVVARAR-AAGIQCRPRDVFVEQTVAR MAB_4099c|M.abscessus_ATCC_199 LGVERVGVDDSFFDLGGDSILSMQVVARAR-AAGVLCRPRDVFIEQTVSR MAV_3244|M.avium_104 LGVERVGVDDSFFDLGGDSILSMQVVARAR-AAGVICRPRDVFVEQTVAR TH_3730|M.thermoresistible__bu LGVERVGVDDSFFDLGGDSILSMQVVARAR-AAGVQCRPRDIFVEQTVAR MMAR_2518|M.marinum_M LGLDRVSVDDSFFDLGGDSLSAMRVVSAAR-AAGLACRTRDIFRHQNVAA Mflv_2697|M.gilvum_PYR-GCK LGVGEIDVTADFLELGLDSIVALSVVQTAR-RRGVVMRAKLMLDCATVRE Mvan_3844|M.vanbaalenii_PYR-1 LGDDGIDVEADFLEMGLDSIVALTLVQAAR-RRGLEMRARLMLECNTIRE MUL_2638|M.ulcerans_Agy99 LGRPVLDPDADFFRIGGHSLAALRVIMRVRERMGVVLQMRDFVSAGTLTG MLBr_02353|M.leprae_Br4923 LGVSSVDRNANFFDLGGDSLMAISISMAAA-NEGMTITPQDMYEHPTLAS ** :. .:: * *: : : . * . . Mb0104|M.bovis_AF2122/97 LADYAPTPDAPTGEDRFRPLVA---AQRPAAIPLSFAQRRLWFLDQLQRP Rv0101|M.tuberculosis_H37Rv LADYAPTPDAPTGEDRFRPLVA---AQRPAAIPLSFAQRRLWFLDQLQRP MSMEG_0400|M.smegmatis_MC2_155 LASVATVAT--EIGV------------VDDGTGSAAPTPIIHWLREAGGA MAB_4099c|M.abscessus_ATCC_199 LAAVAEVSGG-EAYV------------ADEGLGTVAVTPIMHWLRDVDGP MAV_3244|M.avium_104 LARVSQVAVDGELGA------------ADEGIGPVRPTPIMRWLQDIDGP TH_3730|M.thermoresistible__bu LASVVKVSGG-EPET------------VDDGTGAVVATPIMRWLRGVDGP MMAR_2518|M.marinum_M LARVVEHIGADVCLG------------DDDGVGSVALTPIMRWFNSVASL Mflv_2697|M.gilvum_PYR-GCK LAAAIDDAGSGPP---S----------ADEGSGPIALLPNAHWLYEFG-D Mvan_3844|M.vanbaalenii_PYR-1 LATAIDSGAHDHAPAAV----------TDDRFGEVMPAPIMSWMYECG-N MUL_2638|M.ulcerans_Agy99 LQDLIEQKLRQVATAAEVEMLEPAPVDRRAPLPLAPMQANLWYLQQLAPT MLBr_02353|M.leprae_Br4923 LTAAVDASFASSGLAKP----------PEAAAHPAVPPNIAYFLERGLCD * :: Mb0104|M.bovis_AF2122/97 APVYNMAVALRLR----GYLDTEALGAAVADVVGRHESLRTVFPAVD--- Rv0101|M.tuberculosis_H37Rv APVYNMAVALRLR----GYLDTEALGAAVADVVGRHESLRTVFPAVD--- MSMEG_0400|M.smegmatis_MC2_155 TDEFNQTLVVQAP----TGVTEPDVVAVLQALLDRHATLRLRVQ----DS MAB_4099c|M.abscessus_ATCC_199 IVEFNQTLVIQVP----SSVTQDDVVIVLQALLDRHPSLRLRLQ----DN MAV_3244|M.avium_104 IDEFNQTMVLAAP----AGVGVDDVAVVLQALLDRHPMLRLRVQ----DD TH_3730|M.thermoresistible__bu TDQFNQTVVLQAPPGTDTAAAEADVVAVLQALIDRHPTLRMRAEGMTAGD MMAR_2518|M.marinum_M VAGLHQTVLVQGP----AGVDQADVVVLIQALLDRHAMLRLQVAR----D Mflv_2697|M.gilvum_PYR-GCK PRRLASTEALRLP----RGITGPQIRALLQSVVDAHPVLRTRLDR----- Mvan_3844|M.vanbaalenii_PYR-1 YRRFTQNVLVSLP----ADITDSRLEQILQALLDRHDMLRAILDER---- MUL_2638|M.ulcerans_Agy99 MSAYNIVEAVHIR----GEVDTRRLEAAFAAVIERHEALRTIFPYQQ--G MLBr_02353|M.leprae_Br4923 TGRWRVPLILRLD----PKIGSDDIRAVLTAVVNHHDVLRLSLVDND--- : : . :: * ** Mb0104|M.bovis_AF2122/97 -GVPRQLVIEARRADLGCDIVDATAWPADRLQRAIEEAARHS-FDLATEI Rv0101|M.tuberculosis_H37Rv -GVPRQLVIEARRADLGCDIVDATAWPADRLQRAIEEAARHS-FDLATEI MSMEG_0400|M.smegmatis_MC2_155 -DGEWSLLVPDAATVDARDCLSVVDTLS----DDVVLAARAK-LNPAAGA MAB_4099c|M.abscessus_ATCC_199 -DGDWSLLVPEAGAVDARDRLHVVGELS----DEALVAARTA-LDPATGS MAV_3244|M.avium_104 GAGGWSLEAPEVGSVRAADCLRAVDSLS----DAALVEARSR-LNVSDGV TH_3730|M.thermoresistible__bu GTDDWSLFIPEPGATSAREVMHTVDTLT----DEVLIAARSR-LNPAAGV MMAR_2518|M.marinum_M SDGGWSLQARPPGCVDARELMRQAEVMS----GELLAGALSR-LDPAAGV Mflv_2697|M.gilvum_PYR-GCK -----AAMTLVDGGFDLPLTEIEVGDEGSAAVARHAAAALEH-LDPQRGP Mvan_3844|M.vanbaalenii_PYR-1 ----GRLVTRPPGAVRVADVLRVVDAAAHTVLAAEVVAALDR-IDPTSGA MUL_2638|M.ulcerans_Agy99 QPVQVVLAPGGAAPIEHADLCGGGQDDGDARAHELIAELGARPFDLQKDL MLBr_02353|M.leprae_Br4923 GMWEQHIAATGEFTRLLTQTLPDGVAAGSAEERAVVSSILAELIASQSDL : Mb0104|M.bovis_AF2122/97 --PLRTWLFRIADD----EHVLVAVAHHIAADGWSVA-PLTADLSAAYAS Rv0101|M.tuberculosis_H37Rv --PLRTWLFRIADD----EHVLVAVAHHIAADGWSVA-PLTADLSAAYAS MSMEG_0400|M.smegmatis_MC2_155 --MVSALWVRQT-------SQLVLIIHHLAVDGVSWR-ILLEDLNIAWAQ MAB_4099c|M.abscessus_ATCC_199 --MLSAVWVPGT-------AQLALVIHHLAVDGVSWR-ILLEDINIAWAQ MAV_3244|M.avium_104 --LLSAVWASET-------SQLALVVHHLAVDGVSWR-TLIEDINIAWAQ TH_3730|M.thermoresistible__bu --MLSAVWARGS-------GQLVLMIHHLAVDGVSWR-ILVEDLNIAWAQ MMAR_2518|M.marinum_M --MVSAVWVSST-------AQLLLAIHHLAVDGVSWR-VLLDDLNTGWAQ Mflv_2697|M.gilvum_PYR-GCK --LWGAVWLRGSDDADSTSSVLLLTAHVLAMDPVSWQ-IVIGELDAGWHA Mvan_3844|M.vanbaalenii_PYR-1 --MVQAVWFRHG------PPVLALCVHHLSTDVVSWY-LILGALAQIDAT MUL_2638|M.ulcerans_Agy99 --PIRVLLIALG----ADDHYLAWSVHHIAADGWSAAGLLNAELSKAYAA MLBr_02353|M.leprae_Br4923 NEPLTAVQITTAHG---GPHYLGLAVHQMVIDDASRQ-ILGTDIITAFGQ . * * : * * : : Mb0104|M.bovis_AF2122/97 RCAGRAPDWAPLPVQYVDYTLWQREILGDLDDSDSPIAAQLAYWENALAG Rv0101|M.tuberculosis_H37Rv RCAGRAPDWAPLPVQYVDYTLWQREILGDLDDSDSPIAAQLAYWENALAG MSMEG_0400|M.smegmatis_MC2_155 HHSGQQ---VQLPAGGTSFLRWSKRLADHAHT--AEVTAQADAWREILAK MAB_4099c|M.abscessus_ATCC_199 HHGGAD---IELPAGGTSFARWSALLAEHALS--TDVVEQADTWRQVLAT MAV_3244|M.avium_104 HQGGQE---IALPVPGTSFARWSSILAEYAKS--PAVVAAAAAWQQVVAT TH_3730|M.thermoresistible__bu HRTGQP---IDLPANGTSFARWSALLADHARA--PEVVEHVEAWQRVIAA MMAR_2518|M.marinum_M YRRAGA---VSLPAAGSSFRQWATMLVDYAYD--PAVTAQLAAWRQIAAV Mflv_2697|M.gilvum_PYR-GCK LAGGRA---PAALGEHTGYRQWSNLLRERAES--SDG---LQFWLDQLGG Mvan_3844|M.vanbaalenii_PYR-1 LAAGHA---PDPAAEYTTYREWTRRLYQRSRT--EAVERRRGFWVEQLAG MUL_2638|M.ulcerans_Agy99 LGRAAR--LPQLSLQPIDYHHWVAGQITSGDR-----AALEGYWSEHLRD MLBr_02353|M.leprae_Br4923 RLAGEE---ITLEPVTTGWREWSLRCAALATH--PAALDTRSFWIENANK . : * * Mb0104|M.bovis_AF2122/97 MPERLRLPTARPYPPVADQR-GASLVVDWP-ASVQQQVRRIARQHNATSF Rv0101|M.tuberculosis_H37Rv MPERLRLPTARPYPPVADQR-GASLVVDWP-ASVQQQVRRIARQHNATSF MSMEG_0400|M.smegmatis_MC2_155 PAALP---AVQPDTDTHASA-GRFSATLDP-ETTRQLLGEVPAAFHAGVQ MAB_4099c|M.abscessus_ATCC_199 PARVG---TVQPEIDTYANA-GRLSVALDT-ETTRQLLGEVPAAFHAGVQ MAV_3244|M.avium_104 PAVLP---AVGPD-DTYASA-GQLSASLDV-ETTRLLLGEVPAAFHAGVQ TH_3730|M.thermoresistible__bu PSALP---AIRPERDTYATA-GQLSVSLDA-DTTRQLLGAVPAAFHAGVQ MMAR_2518|M.marinum_M PAVIA---APDREVDNAASA-GHLSVVLDA-ATTQALITKVPAAFHAGVH Mflv_2697|M.gilvum_PYR-GCK PDPALGARRVRPDTDRAGDV-RVTVTVTGA-DVT----ARLLAGPHP-VL Mvan_3844|M.vanbaalenii_PYR-1 SDPLLGRRLPDPRHDTWSTL-QSTDVVTDA-GATRAILDRLDGASLE-VR MUL_2638|M.ulcerans_Agy99 APLAIDLPRDFPRPLRGSFRGARVPIVIDD-DDDRAAVRALAREHGATPY MLBr_02353|M.leprae_Br4923 VNLWLADVSLNTDVIQPPGADDLIRMPCTLSVEQTSELDDARRRFRRSIQ Mb0104|M.bovis_AF2122/97 MVVAAGLAVLLSKLSGSPDVAVGFP--------IAGRSDP---------- Rv0101|M.tuberculosis_H37Rv MVVAAGLAVLLSKLSGSPDVAVGFP--------IAGRSDP---------- MSMEG_0400|M.smegmatis_MC2_155 DILLVAFGLAWAEFLNRSGTPITV--------DVEGHGRH---EELAS-- MAB_4099c|M.abscessus_ATCC_199 DILLIAFGLAWNEFLGVSGAPIAF--------DIEGHGRQ---EEIGEAV MAV_3244|M.avium_104 DILLIAFGLACTEFVG-GGAPIGI--------DVEGHGRH---EEIAS-- TH_3730|M.thermoresistible__bu DILLIAFGLAWAEFLGACDSPIGI--------DVEGHGRA---EELAA-- MMAR_2518|M.marinum_M DILLIAFAVAWQEFLADPTGVIGV--------DVEGHGRN---DELSP-- Mflv_2697|M.gilvum_PYR-GCK DVLVAALGRTITEWRGRRNQPTPP-PL----VALETHGRAALAEADTADT Mvan_3844|M.vanbaalenii_PYR-1 DFLLTALTLTLASWRIERGQPAHHGAL----VALEGHGR------EDALV MUL_2638|M.ulcerans_Agy99 SVLVVAFMAWIASRGRQRDIVIGGVTAGREHS------------------ MLBr_02353|M.leprae_Br4923 AIVLAALGRTIAQTVGDGVVAVELE----------GEGRS--------VL .: .: . Mb0104|M.bovis_AF2122/97 ----ALDNLVGFFVNTLVLRVNLAG----------------------DPS Rv0101|M.tuberculosis_H37Rv ----ALDNLVGFFVNTLVLRVNLAG----------------------DPS MSMEG_0400|M.smegmatis_MC2_155 --DIDLSRTVGWFTTKYPVALTVA--DVPWAQVVAGEATLGAVVKDVKEQ MAB_4099c|M.abscessus_ATCC_199 HRRIDLSRTTGWFTTKYPASLAVG--ELSWAQVSAGEAALGPVIKTAKEQ MAV_3244|M.avium_104 --GVDLSRTVGWFTTKYPVALRMGR-RLDWARVVAGEAALGAVIKDAKEQ TH_3730|M.thermoresistible__bu --GVDLSRTVGWFTTKYPVALTIP--KLSWEQVRTGGDALGAAVKAAKEQ MMAR_2518|M.marinum_M --GMDLSATVGWFTTKYPVALHAG--PIAWPQFCTGDTVVGAVVKDLKEQ Mflv_2697|M.gilvum_PYR-GCK ADTADTSDTVGLLSAIYPLRLHE-------DSPG-----------ATTEL Mvan_3844|M.vanbaalenii_PYR-1 GGGVDTSATVGWFTSVYPVRLGAGEAAIDVDTAARNPAAARSLLRAVIQQ MUL_2638|M.ulcerans_Agy99 ----GIENVIGNFASTLPLRCRLRD---------------NPTFADLVVR MLBr_02353|M.leprae_Br4923 RPDVDVRRTIGWFTNYYPIPLVCVK-----------GQGALAQLDAVHNT * : Mb0104|M.bovis_AF2122/97 FAELLGQVRARSLAAYENQD------------VPFEVLVDR-------LK Rv0101|M.tuberculosis_H37Rv FAELLGQVRARSLAAYENQD------------VPFEVLVDR-------LK MSMEG_0400|M.smegmatis_MC2_155 LRAVPDG-LTYGLLRYLNSE---VELGGTEPTIGFNYLGRLGAGAGELSE MAB_4099c|M.abscessus_ATCC_199 LRALPDG-LTYGLLRYLNPG---VDLTGPEPTIGFNYLGRLGAGAGDLSE MAV_3244|M.avium_104 LRALPDG-LSYGLLRYLNPE---IEVQGPDPVIGFNYLGRLGAGA-DLSE TH_3730|M.thermoresistible__bu LRSVPDG-ITYGLLRHLNPD---VELGGAEPAIGFNYLGRLAAGAGDLPD MMAR_2518|M.marinum_M LRAVPEG-LTYGLLRYQNHE---VDFAEPDPPIAFNYLGRFEGFDRLGGS Mflv_2697|M.gilvum_PYR-GCK IAGVPAGGIDYGLLRYLRPDTSEVLKAHPEPQILLNYLGRTDLVPSG--- Mvan_3844|M.vanbaalenii_PYR-1 LAEVPDKGLDYGLLRYTRRD--ETLRALPEPQVEFNYIGRYDLSADQTSQ MUL_2638|M.ulcerans_Agy99 ARDEVQAMVDHSALAFPDIVN-------------VVRAERAGTRNPIFQA MLBr_02353|M.leprae_Br4923 LKSIPHYGIGYGLLRYMYAPTGRVFSAQRTPDIHFRYVGVVP-------- . . . Mb0104|M.bovis_AF2122/97 PTRALTHHPLIQVMLAWQDNPVGQLNLGDLQATPMPIDTRTARMDLVFSL Rv0101|M.tuberculosis_H37Rv PTRALTHHPLIQVMLAWQDNPVGQLNLGDLQATPMPIDTRTARMDLVFSL MSMEG_0400|M.smegmatis_MC2_155 ELWRIEQGSLALTDVVSAVP-MPLAHTVELNAGTMDTDK-GPSLQASWTW MAB_4099c|M.abscessus_ATCC_199 DFWRISADSLRLTDVAAAIS-MPLAHSVELNAGTMDTAA-GPELRANWSW MAV_3244|M.avium_104 EMWRVSADSLSSAAVATAVP-MPLAHTVELNAGTMDTDA-GPQLHANWRW TH_3730|M.thermoresistible__bu ELWRIDPSGLPITEAASKIP-MPLAHTVEVNAGTLDAGPDGPVLQATWTW MMAR_2518|M.marinum_M GGWHLSGAGLMLAETARVMADMPLTHTVALNAVTIDTDA-GPQLHAEWTW Mflv_2697|M.gilvum_PYR-GCK --AIVADRLLLSGLSTVPEPNAAVRHELTVVAAVVAHGD-EPALVAQWRV Mvan_3844|M.vanbaalenii_PYR-1 AWSLITDETLNAHMPAAAEPDLPLRYTFDVISVISGGAD-GPQLRTSWRW MUL_2638|M.ulcerans_Agy99 VVTLFDGDIAPVRIEGAEVSHVAVDPGSAKFDLVASFADDGKTLGGFLEY MLBr_02353|M.leprae_Br4923 ---EPPSVDATVQFDSDMTIPVQEPVPGMGHAIELRTYRFGGSLHLDWWY : Mb0104|M.bovis_AF2122/97 AERFSEGSEPAGIGG----------------------------------- Rv0101|M.tuberculosis_H37Rv AERFSEGSEPAGIGG----------------------------------- MSMEG_0400|M.smegmatis_MC2_155 APSVFDEDKAARLSQLWFEALAGICAHVQAGGGGLTPSDIAPARLTQREI MAB_4099c|M.abscessus_ATCC_199 APSALDGAQADRLSRLWFEALAGICAHVRSGGGGLTPSDLAPARLNQPQI MAV_3244|M.avium_104 ARSVLTDEQLNRLSRLWFEALTGICAHVQAGGGGLTPSDIAPARLDQQQI TH_3730|M.thermoresistible__bu APSLVDEAQIARLSRLWFEALGGVCAHVRSGGGGLTPSDIAPARLTQQQI MMAR_2518|M.marinum_M ASSVFDRGALVKLAGLWFDALAAISAHVDAGGGGLSPADLPGLSLTQSQI Mflv_2697|M.gilvum_PYR-GCK LPEILSDTDVEEMQTIWQD---TLREVL---------------------- Mvan_3844|M.vanbaalenii_PYR-1 STALSTSTEVDRLTALWQQAVTVLGEAL---------------------- MUL_2638|M.ulcerans_Agy99 DRELFKAATAERLAAELVATIGSLTRTPECRIEDYAVGGGAFVAVTPAPL MLBr_02353|M.leprae_Br4923 DIRRIPQVTAEALAQS---------------------------------- : Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MSMEG_0400|M.smegmatis_MC2_155 DQLTTQFEVADVLPLTPLQQGLLFQAGFAEAAGAEAAGVPSDDVYAVQLG MAB_4099c|M.abscessus_ATCC_199 DALVQQYDISDVLPLTPLQQGLLFQAGFAEATG----DSTEDDVYAVQLA MAV_3244|M.avium_104 DELCQQHQIADVLPLSPVQQGLLFHTGFAQELE---------DLYAVQLG TH_3730|M.thermoresistible__bu DELADRHDIADILPLTPVQQGLLFHSAVTRTTA--------DDIYAVQLD MMAR_2518|M.marinum_M DDLERSYPVKDLLPLTPLQQGLLFHSDAFTSGQ----------AYVVQIG Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_2638|M.ulcerans_Agy99 THAQLRIWLLDRRNAGGPE-------------------------LCAQRY MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MSMEG_0400|M.smegmatis_MC2_155 ITLSGSLDPQQLRDAVQAVIRRHPNLAARFVEQ-FGEPVQVLSVDPEIGW MAB_4099c|M.abscessus_ATCC_199 LTLTGALDVARLHDAVSAVAKRHPNLVARFSEE-YGEPVQIILADPVIAW MAV_3244|M.avium_104 ITVSGTLDPHRLRDAVQNAVNRHPNLVARFFDE-FGEPVQIIPAEPEMAW TH_3730|M.thermoresistible__bu LTIAGVVDQHRLRDAVHAVVARHPNLAARFCTD-HDHPVQIIPTEPVAAW MMAR_2518|M.marinum_M IELAGELDPLRLHDAVQTAITRNPNLAARFAYAGLDEPVQIILDDPVVPW Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_2638|M.ulcerans_Agy99 FDLRGKVDVERLHDALELLAQRHPVLRTRFPERATGPVQIIGDAEPVQVR MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MSMEG_0400|M.smegmatis_MC2_155 QFVEFDSGDTGVDERVERLCAAERSAVCKLGEQPVFRAALIR---TADN- MAB_4099c|M.abscessus_ATCC_199 QHVELIG---DIDQQVEQLCAAERAAVCRLFTEPVFRAALISGLGGAEDG MAV_3244|M.avium_104 RYLELDGG--DIDGQLEQLSADERAAVCDLAGQPAFRAALIR---IADD- TH_3730|M.thermoresistible__bu RYLDLRGDDQNPEHEVQQLCAAERAAVRDLTERPTFRAALIR---TGAT- MMAR_2518|M.marinum_M DVIDLSDG---AQRDIEAVSAGQREALRDISNNCPIRAALVK---TAPD- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_2638|M.ulcerans_Agy99 DLRGHDPS--DQESLLRELVCADAARPIDITTDSPLRALILRVVDDRVVL MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MSMEG_0400|M.smegmatis_MC2_155 ---LHRFVLTIHHIVIDGWSLPVLLQEIFAAYFDQSLPSAAPYRNFVTWL MAB_4099c|M.abscessus_ATCC_199 EVGKHRLVLTAHHIVIDGWSLPILLQEIFSIYYGHQLPAPAPYRNFVTWL MAV_3244|M.avium_104 ---RHRLLLTIHHIVIDGWSLPVLLQEVFAGYYGQRLPAPPSYRSYLMWL TH_3730|M.thermoresistible__bu ---EHRFVLTVHHIVIDGWSLPILLQEIFAGYFGQRLPAPARFRDFVTWL MMAR_2518|M.marinum_M ---QYRLILTNHHVVCDGWSMSILLGEVFTRYGNGSLATPVPYREHLVWL Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_2638|M.ulcerans_Agy99 GLNYHQIVADDWAGATILAELSRLYGALGDGPLDDEPPVAPTMGQLALAE MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MSMEG_0400|M.smegmatis_MC2_155 GAQDRDAAQAAWGSVLEGFETPTLVAP--PAQAGPRGVESFR-------L MAB_4099c|M.abscessus_ATCC_199 AGQDRVAAQSVWGRALDGFEAPTLVGS--LATAGRRGVESYR-------I MAV_3244|M.avium_104 SAQDRAAAQDAWREALAGFETPTLVAP--PGKIGRRAVATYT-------V TH_3730|M.thermoresistible__bu AAQDRDAARAAWRELLDGFDTPTLIAP--PGQAGPRGSASYR-------I MMAR_2518|M.marinum_M ADQDRDTALLAWREMFSGFDTPTLVSAQGPGESAQHAVQSLT-------L Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_2638|M.ulcerans_Agy99 SAQPRHRLEETDLPFWDEMLSGLPGRLELPTDFPAPSVASFSGARFESPL MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MSMEG_0400|M.smegmatis_MC2_155 SEATTRTLGELARSQHTTVNTVLQAAWAQLLMWMTGQRDVVFGTAVSGRP MAB_4099c|M.abscessus_ATCC_199 SEDITRSLGELARAQHTTVNTVLQAAWAQVLTWLTGQHDVAFGTAVSGRP MAV_3244|M.avium_104 SADTTKALGELARSSRTTVSTVLQGAWAQLLTWLTGQHDVAFGTAVSGRP TH_3730|M.thermoresistible__bu DTETTAAIGELARTQRTTVNTVLQAAWAHLLMAMTGQRDVVFGTAVSGRP MMAR_2518|M.marinum_M SDAATGALNELARSHHSTLNVVLQAAFAQLLAWLTGHHDVAFGTTVSGRS Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_2638|M.ulcerans_Agy99 PDDVLERLDRFAAQIQVQRSTVVLAMWQYLLHHYSQQDALLVGLPFPARP MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MSMEG_0400|M.smegmatis_MC2_155 VDLAGADSMVGLLINTVPVRATSGVATTVTDLLGQLQRDHNDTVDHEHMA MAB_4099c|M.abscessus_ATCC_199 ADLAGADSMVGLLINTVPVRANITAATTVADLLDQLQRMHNDTVEHEHLA MAV_3244|M.avium_104 TELPGADAMVGLLINTVPVRADIAAATTVVDLLEQLQRAHADTLEHEHLA TH_3730|M.thermoresistible__bu ADLPGADRIVGLLINTIPVRARIGADTTVADLLAQLQHAHNDTLEHEHLA MMAR_2518|M.marinum_M ADLAGSESMVGLLINTVAVRARLTATTTTTELIDQLQQFHTDTLEYHHLP Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_2638|M.ulcerans_Agy99 AG--VSEAAIGYFVNLLPVRADFSPALTLRSLTTATAERLAATTAHADVP MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MSMEG_0400|M.smegmatis_MC2_155 LNEIHRLTGHDRLFDTLFVYENYPIDA---NALLSVQDLAVTDFASREYN MAB_4099c|M.abscessus_ATCC_199 LNEIHHAIGLDRLFDTLFVYENYPIDA---DALLGARELGITDFSSREYN MAV_3244|M.avium_104 LNEIHRVTGHDQLFDTLFLYENYPIDA---SALLDVHELAVTEFSSREFN TH_3730|M.thermoresistible__bu LTEIHHLAGHDQLFDTLFLYESYPIDT---GAFSGAQELAVTGFTNREFN MMAR_2518|M.marinum_M LGDIHRAAGHPRLFDTLFVYENYPIND---LTALCPDQLTITDITSFETT Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_2638|M.ulcerans_Agy99 FEELRERFAARDKAASLIEAAFVPEVPGSYRPTLDGLDVTPVPHDPGRSL MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 ----------------AVEYRTDVFEAQAIDVLIERLRKVLVAVAAAPER Rv0101|M.tuberculosis_H37Rv ----------------AVEYRTDVFEAQAIDVLIERLRKVLVAVAAAPER MSMEG_0400|M.smegmatis_MC2_155 HYPLSMVATPGHEVVLRVEFDTEIFDAASIEALVDRLRRVLDAMATDPGR MAB_4099c|M.abscessus_ATCC_199 HYPLSVVAMPGNELSLRVEFDTDVFDSAEIDTVVDKLRQVLAAMTVDPAT MAV_3244|M.avium_104 HYPLSVVATPGHELSLRVEYDTEVFDEAGIETLIERLRQVLAAMTTDPGQ TH_3730|M.thermoresistible__bu HYPLSVMALPGHELGLRIEYDTEVFDTAAIDALADRFRRVLESMVGDPAR MMAR_2518|M.marinum_M HYPLTVFVLPGPQLGFRVEYDTAAFDKTAMDSLIARLQAVLTVMAAEPGR Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_2638|M.ulcerans_Agy99 FWLSLSLQSDGTALRLVFEYRDALWDAQSIARMAAHLVTLLAAGLTQPDA MLBr_02353|M.leprae_Br4923 --------------------------------FPVTLSKLIQEGIATQKD Mb0104|M.bovis_AF2122/97 TVSSIDALDGTERARLDEWGNRAVLTAPAPTPVSIPQMLAAQVARIPEAE Rv0101|M.tuberculosis_H37Rv TVSSIDALDGTERARLDEWGNRAVLTAPAPTPVSIPQMLAAQVARIPEAE MSMEG_0400|M.smegmatis_MC2_155 RLSTIDLLDPQEHDRLDEWGNRAVLTRPAPALESIPASFAESVRRVPDAV MAB_4099c|M.abscessus_ATCC_199 RLSSIDLLDAGEHDRLDKWGNRAVLIRPEPALTSIPELFAAQVARAPEAI MAV_3244|M.avium_104 RLSAIDLLDAAEHERLDAWGNRAVLTRRPAAQASIPALFAAQVARAADAV TH_3730|M.thermoresistible__bu RLSAIEVLDAAEREQLDAWSNRAVLADS-PALESIPEVFARQVARDPGAV MMAR_2518|M.marinum_M RLSLIDLLDPNEHERLDDWGNRAALTKAVPTPGSLPALFAAQVARTPEAT Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_2638|M.ulcerans_Agy99 TLAEFSMLTQGETDQLRALDGRREIRPAHPALH---RWFEDRARVDPDAE MLBr_02353|M.leprae_Br4923 AHDESEMAGAPQAGVLVDLSTLDAG------------------------- Mb0104|M.bovis_AF2122/97 AVCCGDASMTYRELDEASNRLAHRLAGCGAGPGECVALLFERCAPAVVAM Rv0101|M.tuberculosis_H37Rv AVCCGDASMTYRELDEASNRLAHRLAGCGAGPGECVALLFERCAPAVVAM MSMEG_0400|M.smegmatis_MC2_155 ALSCGDRSWTYRELDEASNRMAHLLAGRGAKPGERVAMLLPRTGEAVVTI MAB_4099c|M.abscessus_ATCC_199 AITCGERSWSYGELDATANRLANHLVTHGARPGERVALLLPRTGEAIAAI MAV_3244|M.avium_104 AITCGERSFTYREVEESANRLAHLLSGQGAGPGQRVAVVIPRSAEAVVAI TH_3730|M.thermoresistible__bu AVTFEGRSMTYGELDDAATELANLLAVYGAGPGESVALLMPRSADAIVAI MMAR_2518|M.marinum_M AITDGDVSLTYAQLDAQSTQLAQALTALGARPGELIALLLPRTHRGIIAI Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_2638|M.ulcerans_Agy99 AVRFLGRGLTYAQLDAESNRLARLLIAGGVRPGDKVAMLLERTPLIPIAV MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 VAVLKTGAAYLPIDPANPPPRVAFMLGDAVPVAAVTTAGLRSRLAGHDLP Rv0101|M.tuberculosis_H37Rv VAVLKTGAAYLPIDPANPPPRVAFMLGDAVPVAAVTTAGLRSRLAGHDLP MSMEG_0400|M.smegmatis_MC2_155 LAILKTGAAYLPIDPAHPDARIEFVLKDAAPVAAVSSADLCTRLIASGVP MAB_4099c|M.abscessus_ATCC_199 LAVLKTGAAYLPIDPAHPDSRVDFVLGDAAPIVAVTTAELLPRLSASGVP MAV_3244|M.avium_104 FAVLKTGAAYVPIDPGVPAARLQFVLADSAPVAAVTTAEVRDRLDGFTGQ TH_3730|M.thermoresistible__bu LAVLKTGAAYLPIDPAVPAARLEFMLSDAEPIVALTTVELGTRFNGTGVP MMAR_2518|M.marinum_M LAVLKTGAGYLPIDPMHPDTRIAFMLNDSTPIAAITTGALHPRLNDYDLP Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_2638|M.ulcerans_Agy99 LAIIKTGAAYVPLDPSWPPQQAELVLCDCAPTAILTETALQHVVADHDAP MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 IIDVVD-ALAAYPGTPPPMPAAVN-LAYILYTSGTTGEPKGVGITHRNVT Rv0101|M.tuberculosis_H37Rv IIDVVD-ALAAYPGTPPPMPAAVN-LAYILYTSGTTGEPKGVGITHRNVT MSMEG_0400|M.smegmatis_MC2_155 VIEVDDPAIGAEASTSLPVPAVDD-IAYIIYTSGTTGTPKGVAVTHRNVA MAB_4099c|M.abscessus_ATCC_199 VIDIDDPAVSAQNDTTLPVPAVDD-IAYIIYTSGTTGAPKGVAVTHRNVA MAV_3244|M.avium_104 IIDFDDPAVAEQPATGLPVPAADN-IAYIIYTSGTTGIPKGVAIPHRNVT TH_3730|M.thermoresistible__bu IIEVDDPAPPMYPSSTLLPPAPDD-IAYLIYTSGTTGVPKGVAITHANVT MMAR_2518|M.marinum_M VIDIENPPTDTTPATNPTTPTPHD-LAYIIYTSGSTGTPKGVGITHHNVT Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_2638|M.ulcerans_Agy99 ILQLDALDLSDQPGTGVDIEVNDDDVAYVIYTSGSTGRPKGVEVTHANVM MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 RLFASLP-----ARLSAAQVWSQCHSYGFDASAWEIWGALLGGGRLVIVP Rv0101|M.tuberculosis_H37Rv RLFASLP-----ARLSAAQVWSQCHSYGFDASAWEIWGALLGGGRLVIVP MSMEG_0400|M.smegmatis_MC2_155 QLLDTLG---AQLELG--QTWTQCHSLAFDYSVWEIWGPLLNGGRLLMVP MAB_4099c|M.abscessus_ATCC_199 QLLESLD---AELALG--QVWTQCHSLAFDYSVWEIWGALLYGGRLLVVP MAV_3244|M.avium_104 LLLETLD---AQLGLG--QVWTQCHSLAFDFSVWEIFGALLHGGRLVIVP TH_3730|M.thermoresistible__bu RVLHTLP---ADLPAGPGKVWSQWHSLVFDVSVWEIWGALLHGGRLVIVP MMAR_2518|M.marinum_M QLLNSFDPQSTAILFSPNRVWTQWHSYSFDVSVWEIWGALLSGARLVVVP Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_2638|M.ulcerans_Agy99 RLFSATEG---LVEFTSADRWTMFHSIAFDFSVWELWGPLLYGGCVVMVP MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 ESVAASPNDFHGLLVAEHVSVLTQTP-------AAVAMLPTQG--LESVA Rv0101|M.tuberculosis_H37Rv ESVAASPNDFHGLLVAEHVSVLTQTP-------AAVAMLPTQG--LESVA MSMEG_0400|M.smegmatis_MC2_155 DAVVRSPEDLHAMLVAEQVSMLSQTPSAFYALQTADALYPERGEQLKLQT MAB_4099c|M.abscessus_ATCC_199 DAVVRSPEELHALLVSEEVSVLSQTPSAFYALQTADALQPEMGQQLKLQT MAV_3244|M.avium_104 DDIVRSPEDLHALLVREQVSVLSQTPSAFYALQSADALAPELGQQLKLQT TH_3730|M.thermoresistible__bu ESITGSPDDLHDLLVAEHVDVVYQTP-------SAAGMLSQRG--LDSTA MMAR_2518|M.marinum_M EHTAKSPDELHALLVAEHVEVLTQTP-------SAAAALSPQG--LESVT Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_2638|M.ulcerans_Agy99 YLETRTPRAFRELLSRERITVLNQTPSAFR---LLRDADAEAATPLYLRY MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 LVVAGEACPAALVDRWAPGR-----VMLNAYGPTETTICAAIS-APLRP- Rv0101|M.tuberculosis_H37Rv LVVAGEACPAALVDRWAPGR-----VMLNAYGPTETTICAAIS-APLRP- MSMEG_0400|M.smegmatis_MC2_155 VVFGGEALEPHRLSGWMHAHPG-MPRMINMYGITETTVHASFR-EIGEAD MAB_4099c|M.abscessus_ATCC_199 VVFGGEALEPQRLSSWFDSHPG-LPRMINMYGITETTVHASFR-EIDDGD MAV_3244|M.avium_104 VVFGGEALEPHRLATWLHRHPG-LPRMINMYGITETTVHASFR-EIVDAD TH_3730|M.thermoresistible__bu LVVAGEACPTDLVDRWAPGR-----VMINAYGPTETTMCVAIS-APLTP- MMAR_2518|M.marinum_M LVVGGEACPAGLVDQWAPGR-----TMINAYGPTEATIYAAMS-SPLVP- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_2638|M.ulcerans_Agy99 VIFGGERLTSSDLIPWIEAHGDSHPDLINMYGITETTVHVTFRRLRREDV MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 -GSGMPPIGVPVSGAALFVLDSWLRPVPAGVAGELYIAGAGVGVGYWRRA Rv0101|M.tuberculosis_H37Rv -GSGMPPIGVPVSGAALFVLDSWLRPVPAGVAGELYIAGAGVGVGYWRRA MSMEG_0400|M.smegmatis_MC2_155 LANSTSPIGVPLEHLSFFVLDGWLRQVPVGVVGELYVAGEGLACGYISRS MAB_4099c|M.abscessus_ATCC_199 VDSNSSPIGVPLEHLAFFVLDGWLRKVPVGVVGELYVAGSGQASGYLGRS MAV_3244|M.avium_104 VDSSVSPIGVPLANLAFFVLDGWLRPVPVGVVGELYVAGGGLATGYVGRP TH_3730|M.thermoresistible__bu -GSGAVPIGTPVPRAALFVLDSWMRPVPAGVIGELYVAGDGVAVGYVGRS MMAR_2518|M.marinum_M -GSGATPIGSPVAGASLFVLDGWLRPVPVGVVGELYVAGGGVGLGYWRRA Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_2638|M.ulcerans_Agy99 LGGRGSRIGRPIPDLECLLTDAAGNLVPLGVRGEICVAGPGLAKGYLGQP MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 GLTASRFVACPFGG-SGARMYRTGDLVCWRADGQLEFLGRTDDQVKIRGY Rv0101|M.tuberculosis_H37Rv GLTASRFVACPFGG-SGARMYRTGDLVCWRADGQLEFLGRTDDQVKIRGY MSMEG_0400|M.smegmatis_MC2_155 DLTSTRFVACPFGA-PGARMYRTGDLVRWGADGQLQYVGRADEQVKIRGY MAB_4099c|M.abscessus_ATCC_199 DLTTTRFVACPFGA-PGSRMYRTGDLVQWGEDGQLRYVGRADKQVKIRGY MAV_3244|M.avium_104 GLSATRFVACPFGG-PGARMYRTGDLVRWGADGQLQYMGRADAQVKIRGY TH_3730|M.thermoresistible__bu ELTASRFVACPFGP-PGSRMYRTGDLVRWGADGQLQYLGRADEQVKIRGY MMAR_2518|M.marinum_M DLTGTRFVACPFGQTPGTRMYRTGDLVWWGTDGQLRYLGRADNQVKIRGF Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_2638|M.ulcerans_Agy99 ELTGQRFVPHPFRP--RERLYRSGDVGRRLPSGEIDYFGRLDHQVQLHGF MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 RIELGEVATALAELAGVGQAVVIAREDRPGDKRLVGYATEIAPGAVDPAG Rv0101|M.tuberculosis_H37Rv RIELGEVATALAELAGVGQAVVIAREDRPGDKRLVGYATEIAPGAVDPAG MSMEG_0400|M.smegmatis_MC2_155 RIELGEVHAALVGLDGVEQAAVIAREDRP--------------------- MAB_4099c|M.abscessus_ATCC_199 RIELGEVHAALARVAGVDQAAVIAREDRPGDKRLVGYITESTAGTLDPTA MAV_3244|M.avium_104 RIELGEIQAALAGLDGVEHAAVIAREDRPGDKRLVGYITG----TADPAE TH_3730|M.thermoresistible__bu RIELGEVQTALTAVDGVENAVVIAREDRPGDKRLVGYITG----TADPDQ MMAR_2518|M.marinum_M RIEPGEVGAALSRMAGVDQAVVIARHDHPGDPRLVGYFTG----NADPTE Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_2638|M.ulcerans_Agy99 RIELGEVENAVSGLEEVVACHAMVR-HDDAKPRLVAYVVTSTGEQLPINS MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 LRAQLAQRLPGYLVPAAVVVIDALPLTVNGKLDHRALPAPEYGD------ Rv0101|M.tuberculosis_H37Rv LRAQLAQRLPGYLVPAAVVVIDALPLTVNGKLDHRALPAPEYGD------ MSMEG_0400|M.smegmatis_MC2_155 -------------------------------------------------- MAB_4099c|M.abscessus_ATCC_199 VRATLAERLPSYMVPAAVVVLDALPLTVNGKLDTRALPAPEFQD------ MAV_3244|M.avium_104 VRAQLGERLPGYMVPSAVVVLDALPLTVNGKLDTRALPAPEYSD------ TH_3730|M.thermoresistible__bu ARARLADRLPAYMVPTAVVVLDALPLTVNGKLDTRALPAPEYQD------ MMAR_2518|M.marinum_M LRAALATQLPHYMVPTALIPIAELPLTVNGKLDTRALPAVQYGH------ Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_2638|M.ulcerans_Agy99 SRQKLTARLPGYMLPSAIVTVESLPLTANGKIDQRALPAPMVAAGAPSAT MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 ----TNGYRAPAGPVEKTVAGIFARVLGLERVGVDDSFFELGGDSLAAMR Rv0101|M.tuberculosis_H37Rv ----TNGYRAPAGPVEKTVAGIFARVLGLERVGVDDSFFELGGDSLAAMR MSMEG_0400|M.smegmatis_MC2_155 --------------------------------------------ATSGWS MAB_4099c|M.abscessus_ATCC_199 ----ADHYRAPEDAVEEILAGIYAQVLGVEQIGVDDSFFDLGGDSISSMQ MAV_3244|M.avium_104 ----VDRYRAPVTAIEEILADIYAQVLGVERVGVDDSFFDLGGDSILSMQ TH_3730|M.thermoresistible__bu ----AEQYRAPTHAVEEVLAGIYAEVLGIDKVGVDDSFFDLGGDSISSMQ MMAR_2518|M.marinum_M ----TQRYRAPDTPVEQTLAAIYAQVLGLDRVSVDDSFFDLGGDSLSAMR Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_2638|M.ulcerans_Agy99 PSETTDSTRNLAASTVDQIRQVFAEVLGLPSVGADDNFFDIGGDSIYAVQ MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 VIAAINTTLNADLPVRALLHASSTRGLSQLLGRDARPTSDPRLVSVHGDN Rv0101|M.tuberculosis_H37Rv VIAAINTTLNADLPVRALLHASSTRGLSQLLGRDARPTSDPRLVSVHGDN MSMEG_0400|M.smegmatis_MC2_155 VMSPARST------------------------------------------ MAB_4099c|M.abscessus_ATCC_199 VVARARAAG-LLLRPRDIFVEQTVSRLAQVA---VFADGEATVVDAGTGP MAV_3244|M.avium_104 VVARARAAG-VICRPRDVFTEQTVARLARVA---TVATGDDDVVDEGTGR TH_3730|M.thermoresistible__bu VVARARAAG-LTIRPRDIFVERTVARLAQVA---VPTGADAAVDDAGTGP MMAR_2518|M.marinum_M VVSAINTTLNTDVAVRVLFDAPTVCTLAQKL---SAPESSVEIVPVEVLQ Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_2638|M.ulcerans_Agy99 LSAKARALG-LAVEVQDLFQCQTPEQLAAGMIR-------TGSAGAALQS MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 PTEVHASDLTLDRFIDADTLATAVNLPGPSPELRTVLLTGATGFLGRYLV Rv0101|M.tuberculosis_H37Rv PTEVHASDLTLDRFIDADTLATAVNLPGPSPELRTVLLTGATGFLGRYLV MSMEG_0400|M.smegmatis_MC2_155 -------------------------------------------------- MAB_4099c|M.abscessus_ATCC_199 VVATPIIRWLHGLGGNVGEFNQTVVLQAPEGVSEDDVVTVLQALLDRHAT MAV_3244|M.avium_104 VVATPIMRWLQNMDGPVEQFNQTMVLAAPAGVTPDDVAAVLQALLDRHAM TH_3730|M.thermoresistible__bu VVATPIMRWLYDTRGPIDQFNQTVVLRAPAGVTEADVVEILQAVLDRHAM MMAR_2518|M.marinum_M DGCGLPLFCLPPGGGISWAYRNLSP------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_2638|M.ulcerans_Agy99 EPRTPMVEGPQPSDLPPGVEDAYPLAALQAGMLLHSRVDGPCIYHDVFSY MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 LELLRRLDVDGRLICLVRAESDEDARRRLEKTFDSGDPELLRHFKELAAD Rv0101|M.tuberculosis_H37Rv LELLRRLDVDGRLICLVRAESDEDARRRLEKTFDSGDPELLRHFKELAAD MSMEG_0400|M.smegmatis_MC2_155 -------------------------------------------RSRPGPR MAB_4099c|M.abscessus_ATCC_199 LRLRAEEN-DGEWALLIPEVGTVDARACLLAVEALSDEALRHARSRLNPA MAV_3244|M.avium_104 LRLRVEDDGAGGWSLEVPEAGSVQAADCLETVDALSPAALVDARSRLNLA TH_3730|M.thermoresistible__bu LRLRAADVEN----LTVPESGAVTARGCLRTVHRLSGDELRSARAELDPA MMAR_2518|M.marinum_M -------------YLDCPIVGLQQIHDGPESVRELAS-AYADAIQTHDPE Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_2638|M.ulcerans_Agy99 LVDAPWDEIAFRAAVDVVTARHPILRTTFDLSGYSRPLQVVREEVCTPLT MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 RLEVVAGDKSEPDLGLDQPMWRRLAETVDLIVDSAAMVNAFPYHELFGPN Rv0101|M.tuberculosis_H37Rv RLEVVAGDKSEPDLGLDQPMWRRLAETVDLIVDSAAMVNAFPYHELFGPN MSMEG_0400|M.smegmatis_MC2_155 SPSGSPRTWCPRR---------------SW-------------------- MAB_4099c|M.abscessus_ATCC_199 TGSMLSALWESGKNRLVLIVHHLAVDAVSWRILLEDFNIAWAQHHGGQAV MAV_3244|M.avium_104 DGILVRAVWASETSQLALIIHHLAVDGVSWRTLIEDLNIAWAQHHSGQPV TH_3730|M.thermoresistible__bu AGTMVRALWAPDTRRLALIVHHLAVDAVSWRILVEDINIAWGQRHTGQPI MMAR_2518|M.marinum_M GPYQLLGWSFGGVTAHQVAVELQQRGAVVVRLIALDPILIRDASTATVVS Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_2638|M.ulcerans_Agy99 VIDLSGQSAAEQEATVAAWMEAESSAAMQWQTQTPFGVVIHVRDGERFEL MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 VAGTAELIRIALTTKLKPFTYVSTADVGAAIEPSAFTEDADIRVISPTRT Rv0101|M.tuberculosis_H37Rv VAGTAELIRIALTTKLKPFTYVSTADVGAAIEPSAFTEDADIRVISPTRT MSMEG_0400|M.smegmatis_MC2_155 -------------------------------------------------- MAB_4099c|M.abscessus_ATCC_199 ELPSGGTSFARWATLLDERARTADVEALTDTWRQVEKIPPALPAVHPTMD MAV_3244|M.avium_104 ALPTGGMSFARWSALLEDHARRPEVVERAEDWRQVAAVPAVLPGAQP-GD TH_3730|M.thermoresistible__bu DLPAGGTSFARWSTLLAEYADTPEVVAQAGVWQQVAAX--XWPSCSTPTT MMAR_2518|M.marinum_M ESDVLEAILQAVGVAAEQYCRPLTYSQAQTLIQQEVDAEFALPSRRLVQI Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_2638|M.ulcerans_Agy99 GLTVHHALLDGWSVAELQRDLLVSYDALRTTGAPPARPRLQNHFREFVML MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 VDG----------------------------------------------- Rv0101|M.tuberculosis_H37Rv VDG----------------------------------------------- MSMEG_0400|M.smegmatis_MC2_155 -------------------------------------------------- MAB_4099c|M.abscessus_ATCC_199 TYASAGQLSVSLDADLTRELLGEVPVAYHAGVQDILLIAFALAWNEFLGS MAV_3244|M.avium_104 TYATAGQLSASLDVETTRLLLGEVPAAFHAGVQDILLIAFGLAWTQFIG- TH_3730|M.thermoresistible__bu TSSSTSTWRSTRS------------------------------------- MMAR_2518|M.marinum_M MVANANTN------------------------------------------ Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_2638|M.ulcerans_Agy99 ESEAEASP------------------------------------------ MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 -GWAGGYGTSKWAGEVLLREANDLCALPVAVFRCGMILADTSYAGQLNMS Rv0101|M.tuberculosis_H37Rv -GWAGGYGTSKWAGEVLLREANDLCALPVAVFRCGMILADTSYAGQLNMS MSMEG_0400|M.smegmatis_MC2_155 -------------------------------------------------- MAB_4099c|M.abscessus_ATCC_199 AGAPIGIDVEGHGRNEEFVADADLSRTVGWFTSKYPVSLAVGELSWAQVV MAV_3244|M.avium_104 TGAPIGIDVEGHGRSEELGPQVDLSRTVGWFTAKYPVALRLGGLSWGQVV TH_3730|M.thermoresistible__bu TGRPVRTGCS---------TRCSSTRTIRSMRRRWPGRKALR-------- MMAR_2518|M.marinum_M -------------------LQLNAQHQPGIFAGRMVLFSAQP-------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_2638|M.ulcerans_Agy99 ---SRAFWLDRLQGFQTLRFAGDRLQHVRPKFRWIELPERIEAGLVRMAR MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 DWVTRMVLSLMATGIAPRSFYEPDSEGNRQRAHFDGLPVTFVAEAIAVLG Rv0101|M.tuberculosis_H37Rv DWVTRMVLSLMATGIAPRSFYEPDSEGNRQRAHFDGLPVTFVAEAIAVLG MSMEG_0400|M.smegmatis_MC2_155 -------------------------------------------------- MAB_4099c|M.abscessus_ATCC_199 AGDPALGPVIKGAKEQLRTLPDGLTYGLLRYLNPDADVAGPDPSIGFNYL MAV_3244|M.avium_104 GGDEALGAVVKEAKEQLRALPDGLTYGLLRYLNPQAGLDVSDPAIAFNYL TH_3730|M.thermoresistible__bu ------SPISRAANTTTIRCRWSQCPGTSSDCASNTTPRCSTPRMSRHWS MMAR_2518|M.marinum_M ---------VRSGADLQQCWRQYVAGEVTEYPVNCTHEELLNPAALKTFG Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_2638|M.ulcerans_Agy99 SRHVPLKSTLLAAHLAVNGRLGATDDVLSGVVVNGRPETDDSASALGMFL MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 ARVAGSSLAGFATYHVMNPHDDGIG-----LDEYVDWLIEAGYPIRRIDD Rv0101|M.tuberculosis_H37Rv ARVAGSSLAGFATYHVMNPHDDGIG-----LDEYVDWLIEAGYPIRRIDD MSMEG_0400|M.smegmatis_MC2_155 -------------------------------------------------- MAB_4099c|M.abscessus_ATCC_199 GRLGAGGVDLSDDLWRIDQDGVAITAAATAVPTPLGHTVELNAGVMEDAD MAV_3244|M.avium_104 GRLGGGAAELSPELWRLSPDSFALAGAAGAVELPLPHTVELNAGTMDTED TH_3730|M.thermoresistible__bu AGCGGC-------------------------------------------- MMAR_2518|M.marinum_M DLIRAALDQP---------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_2638|M.ulcerans_Agy99 NTVPLRIKMTAPDYAGLVDQAFAAERDLLPHRRVPLRAIQRDIGIGGLFE MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 FAEWLQRFEASLGALPDRQRRHSVLPMLLASNSQRLQPLKPTRGCSAPTD Rv0101|M.tuberculosis_H37Rv FAEWLQRFEASLGALPDRQRRHSVLPMLLASNSQRLQPLKPTRGCSAPTD MSMEG_0400|M.smegmatis_MC2_155 -------------------------------------------------- MAB_4099c|M.abscessus_ATCC_199 AGARLHATWTWALSALSHNQVDRISRLWFDSLAGICAHVRGGGGGLSPSD MAV_3244|M.avium_104 G-PHLQANWTWARSALDDKQIGRLSELWFDALAGICTHVRAGGGGLTPSD TH_3730|M.thermoresistible__bu -------------------------------------------------- MMAR_2518|M.marinum_M -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_2638|M.ulcerans_Agy99 TAFNFVSFDKAGASERTPVSAGARDSSTLRRKMIAHTNLPLVTIFAREYG MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 RFRAAVRAAKVGSDKDNPDIPHVSAPTIINYVTNLQLLGLL--------- Rv0101|M.tuberculosis_H37Rv RFRAAVRAAKVGSDKDNPDIPHVSAPTIINYVTNLQLLGLL--------- MSMEG_0400|M.smegmatis_MC2_155 -------------------------------------------------- MAB_4099c|M.abscessus_ATCC_199 VMPARLTQQQIDQLDEQYEIADVLPLTPLQQGLLFHSNLAPEGLEGSDDL MAV_3244|M.avium_104 VAAARLTQRDLDELAQRYRVADVLPLTPLQQGLLFHAG-TAQGSQEPEDL TH_3730|M.thermoresistible__bu -------------------------------------------------- MMAR_2518|M.marinum_M -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_2638|M.ulcerans_Agy99 ALGIGIEYDPRLVSDEQFDAIVAAYLDAIEAIADGGSARLPVFRHETELN MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MSMEG_0400|M.smegmatis_MC2_155 -------------------------------------------------- MAB_4099c|M.abscessus_ATCC_199 YAVQLDVALSGPLDPKRLQDAVHSAIRRRPNVVARFYEEFGEPVQLIPAD MAV_3244|M.avium_104 YAVQLDISVTGAVDPDRLREAVRTVITRHPNVVAHFSEDFGEPVQILSAE TH_3730|M.thermoresistible__bu -------------------------------------------------- MMAR_2518|M.marinum_M -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_2638|M.ulcerans_Agy99 FLRPTG--LVAPHVAANPQEVTRRQLERIWERVLGHPVVGTDSVRDCGGD MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MSMEG_0400|M.smegmatis_MC2_155 -------------------------------------------------- MAB_4099c|M.abscessus_ATCC_199 PELAWQYLELDADSEAEEQVERLAASERAAVCDLAGQPAFRAALARTGTD MAV_3244|M.avium_104 PELAWQYVELDAGADLDEQVERLSSAERVAVGDLA-QPPFRGALIRTAED TH_3730|M.thermoresistible__bu -------------------------------------------------- MMAR_2518|M.marinum_M -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_2638|M.ulcerans_Agy99 SIDAWSSVSTSPPNSSAIRPLPNSSTVPPCSRWRRR-------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MSMEG_0400|M.smegmatis_MC2_155 -------------------------------------------------- MAB_4099c|M.abscessus_ATCC_199 QYRFLVTNHHIVLDGWSKPILLQEIFASYFGERLPAPVAYRRFVTWLSGQ MAV_3244|M.avium_104 AYRFVLTNHHIVLDGWSKPLLLQEIFAAYFGVRLPAPVPYRNFITWLSAQ TH_3730|M.thermoresistible__bu -------------------------------------------------- MMAR_2518|M.marinum_M -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_2638|M.ulcerans_Agy99 -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MSMEG_0400|M.smegmatis_MC2_155 -------------------------------------------------- MAB_4099c|M.abscessus_ATCC_199 DNDAARSAWGKVFEGFETPTLVGPPGRMVLGRRGVESFEVSAETTQALGE MAV_3244|M.avium_104 DRAAAQAAWREVLAGFDTPTLVGPSGRMALGPRGVAEFHVPADTSRLLGE TH_3730|M.thermoresistible__bu -------------------------------------------------- MMAR_2518|M.marinum_M -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_2638|M.ulcerans_Agy99 -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MSMEG_0400|M.smegmatis_MC2_155 -------------------------------------------------- MAB_4099c|M.abscessus_ATCC_199 LARSCRTTVSTVLQAAWAQLLMWLTGQTDVAFGTAVSGRPTDLVGAESMV MAV_3244|M.avium_104 LARSCRTTVSTVLQAAWAQLLMWLTGQHDVVFGTAVSGRPTELAGSESMV TH_3730|M.thermoresistible__bu -------------------------------------------------- MMAR_2518|M.marinum_M -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_2638|M.ulcerans_Agy99 -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MSMEG_0400|M.smegmatis_MC2_155 -------------------------------------------------- MAB_4099c|M.abscessus_ATCC_199 GLLINTVPVRATITPDTTIASLLNQLQAAYGETLEHQHLALKEIHHAVGH MAV_3244|M.avium_104 GLLINTVPVRATIGAETTIADLLDQLQRAYTHTLEHQHLALNDIHRVTGH TH_3730|M.thermoresistible__bu -------------------------------------------------- MMAR_2518|M.marinum_M -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_2638|M.ulcerans_Agy99 -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MSMEG_0400|M.smegmatis_MC2_155 -------------------------------------------------- MAB_4099c|M.abscessus_ATCC_199 DQLFDTMFVYENYPIDTAALSRVHELSITGFSNREYNHYPLAVQATPGHE MAV_3244|M.avium_104 DQIFDTMFVYENYPIDTAALSAVDELTITGFTNREYNHYPLSVQAVPGHE TH_3730|M.thermoresistible__bu -------------------------------------------------- MMAR_2518|M.marinum_M -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_2638|M.ulcerans_Agy99 -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 ------------------------------------------- Rv0101|M.tuberculosis_H37Rv ------------------------------------------- MSMEG_0400|M.smegmatis_MC2_155 ------------------------------------------- MAB_4099c|M.abscessus_ATCC_199 LGLRVEFDTDVFNAVRIGKLVKRFQRVLEAMTSDVKGKKKEPT MAV_3244|M.avium_104 IGLRVEFDTDVFGEARIEKLIERFRRVLEAMTVDLEEQS---- TH_3730|M.thermoresistible__bu ------------------------------------------- MMAR_2518|M.marinum_M ------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK ------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 ------------------------------------------- MUL_2638|M.ulcerans_Agy99 ------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------