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TVGAGRRLLSIDLLDGGEHDRLDEWGNRAILTKPVKAPASIPGMFAAQVARSAEAVALSFEGRSMTYREL DEASNRLAHLLAEQGAAPGECVALLFSRSDEAIVSILAVLKTGAAYLPIDPALPAARMEFMLGDATPIAA VTTAGLRDRLEGFDLPVIDVDEAAAEIERTQPSSALPGPSPDDIAYMIYTSGTTGTPKGVAVTHRNVTEF LKTLHPKLPSGPGQVWSQWHSLVFDVSVWETWGALLHGGRLVVVPESVAGSPDDLHDLLVAEGVTVLSQT PSAVGMLSPEGLDSTALVVAGEACPAEVVDRWAPGRVMINAYGPTEATVYAAMSAPLTAESGAPPIGSPV PGAALFVLDKWLRPAPEGVVGELYIAGRGVATGYARRAGLTASRFVACPFGGPGARMYRTGDLVRWGADG QLQYLGRADEQVKIRGYRIELGEIQSALAALDGVDQAAVIAREDRPGDKRLVGYITGTADPAELRTQLGK RLPAYMVPAAVVVLESLPLTVNGKLDKRALPAPEYHKRAGQYRAPSNHTEEILADIYAQVLGVERVGVDD SFFDLGGDSILSMQVVARARAAGVICRPRDVFVEQTVARLARVASDGADEEQVVDEGIGPVQATPIMRWL QTVQGPIDDFNQTMVLAAPSGVTADDVAVVLQALLDRHPMLRLRVEDDGAGGWNLQAPEPGSVRAADCLQ SVDTLSDAVLVAARSRLNPGAGVMVSAVWASETSQLALIIHHVAVDGVSWRTLIEDLNIAWAQHHSGQPV ALPAGGTSFARWSSLLAEHALTPAVVEQADAWREVVATPAVLPAVQPEVDTYQSAEQLSVSLDVDTTRLL LGEVPAAFHAGVQDILLIAFAMAWTQVVGAGTPIGIDVEGHGRHEELGPHVDLSRTVGWFTTKYPVALAI DGLDWASVVAGDDALGAAVKAAKEQLRALPDGLTYGLLRYLNPDVDLGGSDPVIGFNYLGRLGAAADLPG ELWRLSPDSLSLSGAAAAVAMPLMHTVDLNAGTMDTEDGPHLHANWTWAPSAVDRDQISRLSQLWFEALA GICAHVRAGGGGLTPSDILPARLNQRQIDELSKQHQIADILPLTPLQQGLLFHASFAQDPGDDVYAVQLG ITVTGALDSHRLHDAVHTVVNRHPNLAARFCPQYGEPVQVVPADPVMAWRYIQLGPEDVDPEQKVEELCA AERAAVSDLANRPAFRAALIRTADNRHRFVLTNHHIVMDGWSLPILLREILAIYYGDQLPAPATYRSYLT WLAGQDRSAAQAAWRQVLDGFDTPTLVGPAGRMRLGRRAVESYRLSADTTRALGELARACHTTVNTVLQA GWAQLLMRLTGQHDVAFGTAVSGRPADLAGAESMVGLLINTVPVRANTHAETTVADLLDQLQQHHNDTLE HEHLALSEIHRVTGHDALFDTLFLYENYPIDTSVPLGFHELAITDVTNREYNHYPLSVMALPGRELGLRV EFDTDVFDAAGIEKLTERFQRVLSEMTADPTRRLTSLEVMDEAEHELLDAWGNRPVLSQPATGTSIPALF AAQVARTPDAAALTFQGRSMSYRELDEASNRLAHLLIEEGAGPGECVALLFSRSAEAIVSILAVLKTGAA YLPIDPALPAARIEFLLGDAEPVAVVTTAALRSRLDGCKPSVVDVDDPALDGQPSAALPVPSSDNIAYLI YTSGTTGVPKGVAVSHDNVAQLVESLHADLPEGGVWAQWHSLVFDVSVHEIWGALLHGGRLVVVPESVAA SPDELHDLLVAEGVTVLSQTPSAVGMLSPEGLDSTALVVAGEACPVEIVDRWAPGRVMINAYGPTEATVY AAMSTPLQPGTGSAPIGSPVPRAALFVLDRWLRPAPPGVVGELYIAGHGVATGYARRSGLTASRFVACPF GGPGARMYRTGDLVRWNQDGQLEYLGRADEQVKLRGYRIELGEVQAALAGLDGVEQAAVIAREDRPGDKR LVGYITGTADPVGIRIQLAERLPAYMVPAAVVVLDALPLTVNGKLDKRALPAPEYRKRGGEYIAPTNPTE ETVAGIFARVLGMERVSIDDSFFELGGDSLSAMRVIAEINTAVDGALSVRTLFDSQSVRALSQRITSGAD AENAAGPGFAAVHGADAKEVYARDLTLDKFLDATTLSTAPTLPGPSPEVRTVLLTGATGFLGRYLVLEWL EQLEQVDGKLICLVRARSDEEAWGRLEKTFNTGDPELLRHFQELAEEHLQVVAGDKGQANLGLDEQTWQQ LADTVDLIVDSAAVVNGVLPYSELFTPNVGGTAELIRLALTTRKKPFAYVSTSDVGRQIEPSAFTEDADI RVISATRVIDGSYANGYGNSKWAGEVLLREAHDLCGLPVSVFRSDMILADTSYAGQLNVTDIFTRMILSI VATGTAPKSFYRLDADGNRQRSHFDALPVEFVAEAIAKLGAQVMDGFETYHVMNPHDDGIGLDEYVDWLI EAGYPIERVDDFGEWLQRFETGLRGLPERQRQNSVLQMLLLLLRDPKNLQLAEPARGAFAPTDRFRAAVQ EAKVGSDNDIPHISAPVIVKYVTDLQLLGLL*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. avium 104 | MAV_3243 | - | - | 100% (2552) | linear gramicidin synthetase subunit B |
M. avium 104 | MAV_3239 | - | 0.0 | 69.46% (2125) | syringomycin synthetase |
M. avium 104 | MAV_3244 | - | 0.0 | 68.45% (2133) | linear gramicidin synthetase subunit D |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0104 | nrp | 0.0 | 56.58% (1513) | peptide synthetase |
M. gilvum PYR-GCK | Mflv_2697 | - | 1e-157 | 35.73% (1069) | amino acid adenylation domain-containing protein |
M. tuberculosis H37Rv | Rv0101 | nrp | 0.0 | 56.58% (1513) | peptide synthetase |
M. leprae Br4923 | MLBr_00484 | fadD9 | 0.0 | 39.62% (1156) | putative acyl-CoA synthetase |
M. abscessus ATCC 19977 | MAB_4098c | - | 0.0 | 68.62% (2591) | peptide synthetase NRP |
M. marinum M | MMAR_0099 | - | 0.0 | 60.99% (2130) | non-ribosomal peptide synthetase |
M. smegmatis MC2 155 | MSMEG_0402 | - | 0.0 | 71.65% (2561) | linear gramicidin synthetase subunit D |
M. thermoresistible (build 8) | TH_3730 | - | 0.0 | 66.37% (1998) | PUTATIVE linear gramicidin synthetase subunit D |
M. ulcerans Agy99 | MUL_1722 | - | 0.0 | 40.29% (1154) | fatty-acid-CoA ligase FadD9 |
M. vanbaalenii PYR-1 | Mvan_2578 | - | 0.0 | 41.34% (1149) | thioester reductase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK --MTAAKTGAIADVMALSPLQQGLYSLTAMS--DGDDPYLIGMSADITGA MMAR_0099|M.marinum_M MTQPTKPVVDIEDVMTLSPLQLGLFALAMASGAASDDPYTVALGIDVHGS Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK LDVSLLHDCAAAVLARHPNLRAGFFQGDLKRPVQVIPEKVEVLWRHVRCD MMAR_0099|M.marinum_M LDVGLLRSCALAMLKRHPNLRARFLGRGLPHPVQVVPSEVQLEWARVEAT Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK GTEVEPLEREERARRFDLGRGPAMRFLLLETGQQRWRFVITAHHIVIDGW MMAR_0099|M.marinum_M AETAGALEAQERNRGFDLEMGPAIRFLLIELPGDRWRFLITAHHIVIGGW Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK SLSLLVSELLALYRAAGNTSALPDAPRPYRDYIGWLAARDQDHARSLWRA MMAR_0099|M.marinum_M SIALFVDELLTLYEADCNIDTLPAQPRPYRDYIGWLERCDVEQGQRQWRE Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK HLADLDGPTLLAPALGAATIG-DGLPGMVELTADPSITEAVVDAARARGV MMAR_0099|M.marinum_M HLAGLAAPTLLAAPLGSSGVQPDSLPKRAELTLDEGATTSLVDGARSRGV Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK TVNSLVQLAWALTLSSLTDRDDITFGVTVSGRPDDLAGVESMIGLFVNTV MMAR_0099|M.marinum_M TVNTLTQLAWALMLSMLTDRRDVVFGVTVSSRPAELARVESMVGLFVNTV Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 --------MSADP-TRTLLSMDLLDDDDHDRLDEWGNRAVLTE------- MSMEG_0402|M.smegmatis_MC2_155 --------MTAEPSTRTLLSFDLLDEDEHDQIEVWGNRAVLTD------- MAV_3243|M.avium_104 --------MTVGA-GRRLLSIDLLDGGEHDRLDEWGNRAILTK------- TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK PLRVRLDPALTAGAQCRALQQDAATLRDHSYLGHAELRALAGVGELFDTL MMAR_0099|M.marinum_M PLRVRLDPKTTVAQQCALIQRDAARLREHAYLSHSQIRALAGMGELFDTL Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 ---------------------------PAAEPVSIPVVFAVQVERAPETV MSMEG_0402|M.smegmatis_MC2_155 ---------------------------PGPTPVTIPALFAEQVVRAPDAV MAV_3243|M.avium_104 ---------------------------PVKAPASIPGMFAAQVARSAEAV TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK LVYENFPPGAVAGAGTLEAAGATFTPVALQSLAHFPVTIAAHLTDGRLTV MMAR_0099|M.marinum_M LVFQNFPSLGLADGKARAVGAARFDSLTVQSPTHFPVCITAELTDARLSL Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 ALVCRD-------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 ALVSGD-------------------------------------------- MAV_3243|M.avium_104 ALSFEG-------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK LVEAKDGALGQITPRALGTRLLATVSRIVEGWDRPLREISISPD------ MMAR_0099|M.marinum_M SIATNANAFGDITESALGDRLVAVLQRLLPMWDRPLRDVSMLLDGQTDGD Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK ----------------------DHPVPVP--------------------- MMAR_0099|M.marinum_M TAVSEHARLDVVGNRAVLAEPLVEPVSVPGLFAAQVASRAEVTALVCGDR Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M SLTYRELDRAANRLAHLLVDQGVGPGDVVGLLLERSVEAVIAILAVLKSG Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M AAYLAIDVNHPDGRIGFMIEDAAPVAVITTAGLAQRLAGYPVAVIDIDDP Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK ------------------------------------------------VS MMAR_0099|M.marinum_M AIATCYPGYGLPFPSADNIAYLIYTSGTTGKPKGVGITHHNITQLFTSVA Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK EAAPTPSP------------------------------------------ MMAR_0099|M.marinum_M ATGFTPAPGQIWTQCHSYAFDYSVWEMWGALLHGGRLVVVPELVTRSAAE Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M LLALLVTEGVGVLSQTPSAFYALQAEDAAQPQLGRQLCLDAVVFGGEALE Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK ------------------------STGVHTRFTETA-------------- MMAR_0099|M.marinum_M PARLGPWLANHGRRPRLINMYGITETTVHASFREIVRHDLGFAVSPVGVP Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M LANLAFFVLDGWLRPVPVGVAGELYVAGAGVGCGYWRRSGLTASRFVACP Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M FGALGARMYRTGDVVRWGPDGQLQYVGRADEQVKIRGYRIELGEVAAALS Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M QLDGVDQAVVIAREDRPGDKRLVGYLVGSVDAGQARAALAQALPAYMVPA Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M AVVVVDSLPLTVNGKLDIRALPAPQYGATGSYRAPASPVEEVLAGIYAQV Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M LGLDRVAVDQSFFDLGGDSLSAMRVVAAINKSLGGDLSVRALFDAPTVAE Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M LAPGIGQGSGQWTPLVAGERPAVVPLSFAQQRLWFIDQLQGPSAVYNMAW Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK SARLG--------------------------------------------- MMAR_0099|M.marinum_M SARLSGELDAAALGAAFADVVGRHESLRTVFRAVAGVAEQLVLGVEQVDV Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M RWQIIDAQGWSSRRLAAALEQQARHCFDLTVEIPLRASLFRVTDDEHVLV Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M VVAHHIAADGWSLRPLVTDLGVAYASRCAGRAPGWAGLAVQYVDYTLWQR Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M TNLGELTDSHSGIAGQLRYWEKALEGMAERLQLPTDRAYPRVADHRGSGV Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M DVQWPAQLQQQVARVAREHHATSFMVIQTALAVLLAKLSGSSDVAVGVPV Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M AGRGDPALDELVGVFVNTVVLRVQVAGDPTFAQLLAQVRTRSLAAFEHQD Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK ----------------------SVALSWD--------------------- MMAR_0099|M.marinum_M VPFEVLVERLNPVRSLTHHPLVQVVLAWQNDMSAELVLDGLDVEFAPVHT Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK ------------------------GG------------------------ MMAR_0099|M.marinum_M QTARMDLVFSLGERFTDTGAPAGIGGGVEFRTDVFDAASIAALIQRLQRV Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M VVAMVADPDRRLSSVDLLDAAEHARLDVVGNRAVLAEPLVEPVSVPGLFA Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 ----------------RSWTYRELDQITNRIAHLLAGNGAGPGEVVGLLV MSMEG_0402|M.smegmatis_MC2_155 ----------------RSWTYRELDEASNRLAHVLAEHGAKPGATVAFLI MAV_3243|M.avium_104 ----------------RSMTYRELDEASNRLAHLLAEQGAAPGECVALLF TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -----------------ALTYRQLDEAADRLAAVLTASGVRTETPVAVRL MMAR_0099|M.marinum_M AQVASRAEVTALVCEDRSLTYRELDRAANRLAHLLVDQGVGPGDVVGLLL Mb0104|M.bovis_AF2122/97 -------------MHRVRLSRSQRNLYNGVRQDNNPALYLIGKSYRFRRL Rv0101|M.tuberculosis_H37Rv -------------MHRVRLSRSQRNLYNGVRQDNNPALYLIGKSYRFRRL MLBr_00484|M.leprae_Br4923 ---------------------MWRQQSISHRKESVMSTITKQEKQLARRV MUL_1722|M.ulcerans_Agy99 -----------------------------------MSPITREER-LERRI Mvan_2578|M.vanbaalenii_PYR-1 -----------------------------------MSTDTREDR-LARRI MAB_4098c|M.abscessus_ATCC_199 PRSGEAIIGLLAILKTGAAYLPIDPAHPDERIKFMVSDAGPVAVLTTADL MSMEG_0402|M.smegmatis_MC2_155 PRSGEAILSILSVLKTGAAYLPVDPAHPDARIGFMMSDAKPVAALTTADL MAV_3243|M.avium_104 SRSDEAIVSILAVLKTGAAYLPIDPALPAARMEFMLGDATPIAAVTTAGL TH_3730|M.thermoresistible__bu --------------------------------------------VTTAEL Mflv_2697|M.gilvum_PYR-GCK RRGADYVVAMFAVLKAGGAIVPLDPAMPADRIEVILRRAGVTVVVDEDTV MMAR_0099|M.marinum_M ERSVEAVIAILAVLKSGAAYLAIDVNHPDGRIGFMIEDAAPVAVITTAGL Mb0104|M.bovis_AF2122/97 ELARFLAALHATVLDNPVQLCVLENSGADYPDLVPRLRFGDIVRVGSADE Rv0101|M.tuberculosis_H37Rv ELARFLAALHATVLDNPVQLCVLENSGADYPDLVPRLRFGDIVRVGSADE MLBr_00484|M.leprae_Br4923 DDLTANDPQFAAAKPDPAVAAALAQPGLRLPQIIQ--------------- MUL_1722|M.ulcerans_Agy99 QDLYANDPQFAAAKPVTAITAAIERPGLPLPQIIE--------------- Mvan_2578|M.vanbaalenii_PYR-1 ADLYATDPQFAAAAPDDAISHAIDQPGTHLPVIVQ--------------- MAB_4098c|M.abscessus_ATCC_199 GSRFEGLDVSVIEIDDPLIDGQ---PSSALPTPEPDDLAYMTYTSGTTGV MSMEG_0402|M.smegmatis_MC2_155 RSRLDQYDLAVIDMADPAIDRR---PSDALSGPRPDDLAYMTYTSGTTGV MAV_3243|M.avium_104 RDRLEGFDLPVIDVDEAAAEIERTQPSSALPGPSPDDIAYMIYTSGTTGT TH_3730|M.thermoresistible__bu GARLHRSGVPVIHIDDPAAPGQAG--ATTGPAPAPDDIAYIIYTSGTTGV Mflv_2697|M.gilvum_PYR-GCK ARATAEPP-----------AQYRP--AETLPG----QAAYVVFTSGTTGE MMAR_0099|M.marinum_M AQRLAGYPVAVIDIDDPAIATCYP--GHGLPFPSADNIAYLIYTSGTTGK Mb0104|M.bovis_AF2122/97 HLQSTWCSGILGKPLVRHTVHTDPNGYVTGLDVHTHHILLDGGATGTIEA Rv0101|M.tuberculosis_H37Rv HLQSTWCSGILGKPLVRHTVHTDPNGYVTGLDVHTHHILLDGGATGTIEA MLBr_00484|M.leprae_Br4923 -------------------------------------TALDGYAERPALG MUL_1722|M.ulcerans_Agy99 -------------------------------------TVMTGYADRPALA Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------TVLDGYAERPALG : . MAB_4098c|M.abscessus_ATCC_199 PKAVAVTHHNVTQLVD----AVRADLPARPGEVWSQWHSLVFDV-SVWEI MSMEG_0402|M.smegmatis_MC2_155 PKAVAVTHHNVTQLVS----ALHADLPSGPGQVWSQWHSLVFDV-SVWEI MAV_3243|M.avium_104 PKGVAVTHRNVTEFLK----TLHPKLPSGPGQVWSQWHSLVFDV-SVWET TH_3730|M.thermoresistible__bu PKGVAVTHRNVAALLS----ALDAELAS--GQVWTQCHSLAFDF-SVWEI Mflv_2697|M.gilvum_PYR-GCK PKGVIGTHRALLAYADDHIGAILRPAADRVGRPLRIAHAWSFTFDAAWQP MMAR_0099|M.marinum_M PKGVGITHHNITQLFTSVAATGFTPAP---GQIWTQCHSYAFDY-SVWEM Mb0104|M.bovis_AF2122/97 DLARYLTTDPAGETPSVGAGLAKLREAHRRETAKVEESRGRLSAVVQREL Rv0101|M.tuberculosis_H37Rv DLARYLTTDPAGETPSVGAGLAKLREAHRRETAKVEESRGRLSAVVQREL MLBr_00484|M.leprae_Br4923 QRVAEFTKDPK-------TGRTSMELLPSFETITYRQLGDRVGALARAWR MUL_1722|M.ulcerans_Agy99 QRSVEFVTDAG-------TGHTTLRLLPHFETISYGELWDRISALADVLS Mvan_2578|M.vanbaalenii_PYR-1 QRAVRFVTDPA-------TGRTTTELLPRFETITYAELSRRIHAVTAALT . . MAB_4098c|M.abscessus_ATCC_199 WGALLHGGRLVVVPESVASSPDDLHELLISEKVSVLCQTPS------AAG MSMEG_0402|M.smegmatis_MC2_155 WGALLHGGRLVVVPESVGSSPDDLHNLLITEKVSVLCQTPS------AAG MAV_3243|M.avium_104 WGALLHGGRLVVVPESVAGSPDDLHDLLVAEGVTVLSQTPS------AVG TH_3730|M.thermoresistible__bu WGPLLYGGRVVIVPDPVVRSPEDLHALLAAEQVGMLSQTPSAFYALQTAD Mflv_2697|M.gilvum_PYR-GCK LAALLDGHSVHIVDDATQRDAEALVDTIARFGVDMIDTTPSMFARLRDVG MMAR_0099|M.marinum_M WGALLHGGRLVVVPELVTRSAAELLALLVTEGVGVLSQTPSAFYALQAED Mb0104|M.bovis_AF2122/97 ADEAYHGGHGHSVSDAPGTAAKGVLHESATICGNAFDAILTLSEAQRVPL Rv0101|M.tuberculosis_H37Rv ADEAYHGGHGHSVSDAPGTAAKGVLHESATICGNAFDAILTLSEAQRVPL MLBr_00484|M.leprae_Br4923 -HDLLHAGYRVCVLGFNSVDYAIIDMALGVIG--------------AVAV MUL_1722|M.ulcerans_Agy99 TEQTVKPSDRVCLLGFNSVDYATIDMTLARLG--------------AVAV Mvan_2578|M.vanbaalenii_PYR-1 ---DVHPGDRVAVLGFTSIDYTTVDMALAMLG--------------AVAV : : MAB_4098c|M.abscessus_ATCC_199 MLSPE---RLESTTLIVAGEACPPELVDRWATS----------------- MSMEG_0402|M.smegmatis_MC2_155 MLSPE---GLESTTLIVAGEACPTELVDRWAP------------------ MAV_3243|M.avium_104 MLSPE---GLDSTALVVAGEACPAEVVDRWAP------------------ TH_3730|M.thermoresistible__bu SLQPEQARQLQLQTVVFGGEALEPQRLSAWMRN----------------- Mflv_2697|M.gilvum_PYR-GCK LLSTVP-----LAVLALGGEAVDPGLWQQIRQEC---------------- MMAR_0099|M.marinum_M AAQPQLGRQLCLDAVVFGGEALEPARLGPWLANH---------------- Mb0104|M.bovis_AF2122/97 NVLVAAAAVAVDASLRQNTETLLVHTVDNRFGDSDLNVATCLVNSVAQTV Rv0101|M.tuberculosis_H37Rv NVLVAAAAVAVDASLRQNTETLLVHTVDNRFGDSDLNVATCLVNSVAQTV MLBr_00484|M.leprae_Br4923 PLQTSAAITQLQSIVTETEPSMIATSVN---------------------- MUL_1722|M.ulcerans_Agy99 PLQTSAAITQLQPIVAETQPTMIAASVD---------------------- Mvan_2578|M.vanbaalenii_PYR-1 PLQTSAPATTVRPIVAETEPVVIASSVD---------------------- : MAB_4098c|M.abscessus_ATCC_199 ---GRTMINAYGPTEATIYAAMSGP--LTPGSGVAPIGSPVPGAALFVLD MSMEG_0402|M.smegmatis_MC2_155 ---GRVMINAYGPTEATIYAAMSEP--LTAGTGVAPIGAPVPGAALFVLD MAV_3243|M.avium_104 ---GRVMINAYGPTEATVYAAMSAP--LTAESGAPPIGSPVPGAALFVLD TH_3730|M.thermoresistible__bu HPERPRLINMYGITETTVHASFREIGAADLDDNTSPIGRPLPHLAFFVLD Mflv_2697|M.gilvum_PYR-GCK ARTGMSAFNCYGPTETTVEAVVAEIGAHER----PTIGRPTAPTRAYVLD MMAR_0099|M.marinum_M GRR-PRLINMYGITETTVHASFREIVRHDLGFAVSPVGVPLANLAFFVLD Mb0104|M.bovis_AF2122/97 RFPPFASVSDVVRTLDRGYVKAVRRRWLREEHYRRMYLAINRTSHVEALT Rv0101|M.tuberculosis_H37Rv RFPPFASVSDVVRTLDRGYVKAVRRRWLREEHYRRMYLAINRTSHVEALT MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 KWLRPAPEGVVGELYVAGNGVAPGYAHRSGLTASRFLACPFGGPGSRMYR MSMEG_0402|M.smegmatis_MC2_155 KWLRPAPEGVVGELYVAGHGVATGYIGRPDLTASRFVACPFGETGERMYR MAV_3243|M.avium_104 KWLRPAPEGVVGELYIAGRGVATGYARRAGLTASRFVACPFGGPGARMYR TH_3730|M.thermoresistible__bu GWLRPVPPGVVGELYVAGAGLATGYVSRSDLTSTRFVACPFGPPGTRMYR Mflv_2697|M.gilvum_PYR-GCK SWLRPVPSGAAGELYLAGGQLTRGYLGRPGETAARFVPDPF-VPGARMYR MMAR_0099|M.marinum_M GWLRPVPVGVAGELYVAGAGVGCGYWRRSGLTASRFVACPFGALGARMYR Mb0104|M.bovis_AF2122/97 LNFIREPCAPGLRPFLSEVPIATDIGPVEGMTVASVLDEEQRTLNLAIWN Rv0101|M.tuberculosis_H37Rv LNFIREPCAPGLRPFLSEVPIATDIGPVEGMTVASVLDEEQRTLNLAIWN MLBr_00484|M.leprae_Br4923 ------------------------------------QLPDTVELILSGQA MUL_1722|M.ulcerans_Agy99 ------------------------------------ALADATELALSGQT Mvan_2578|M.vanbaalenii_PYR-1 ------------------------------------ALTDAVGLALDAPT MAB_4098c|M.abscessus_ATCC_199 TGDLVQWGEDGQLQYLGRADEQVKIRGYRIELGEIQAALSRLDGVEQAVV MSMEG_0402|M.smegmatis_MC2_155 TGDLVRWGSDGQLEYLGRADEQVKIRGYRIELGEIQAALAKLDGVDQAVV MAV_3243|M.avium_104 TGDLVRWGADGQLQYLGRADEQVKIRGYRIELGEIQSALAALDGVDQAAV TH_3730|M.thermoresistible__bu TGDLVRWDTGGELHYIGRADEQVKIRGYRIELGEIQAALARLDGVDQAAV Mflv_2697|M.gilvum_PYR-GCK TGDVVRRAVDGTLAFLGRSDTQVKIRGFRVEPGEVAAVLRTHPAVGQAYV MMAR_0099|M.marinum_M TGDVVRWGPDGQLQYVGRADEQVKIRGYRIELGEVAAALSQLDGVDQAVV Mb0104|M.bovis_AF2122/97 RADLPACKTHPKVAERIAAALESMAAMWDRPIAMIVNDWFGIGPDGTRCQ Rv0101|M.tuberculosis_H37Rv RADLPACKTHPKVAERIAAALESMAAMWDRPIAMIVNDWFGIGPDGTRCQ MLBr_00484|M.leprae_Br4923 PAKLVVFDYHPEVDEQHDAVATARARLADS--SVVVESLTEVLGRGKTLP MUL_1722|M.ulcerans_Agy99 ATRVLVFDHHRQVDAHRAAVESARERLAG---SAVVETLAEAIARGDVPR Mvan_2578|M.vanbaalenii_PYR-1 VTRLVVFDHRAGVDDHRDALISASDRLRAANSPIEVETITDIVARGSKLP : : : MAB_4098c|M.abscessus_ATCC_199 IAREDRPGDKRLVG------------------------------------ MSMEG_0402|M.smegmatis_MC2_155 IAREDRPGDKRLVG------------------------------------ MAV_3243|M.avium_104 IAREDRPGDKRLVG------------------------------------ TH_3730|M.thermoresistible__bu IAREDRPGDKRLVG------------------------------------ Mflv_2697|M.gilvum_PYR-GCK AVRPHRDG-HRLTA------------------------------------ MMAR_0099|M.marinum_M IAREDRPGDKRLVG------------------------------------ Mb0104|M.bovis_AF2122/97 GDWPARQPSTPAWFLDSARGVHQFLGRRRFVYPWVAWLVQRGAAPGDVLV Rv0101|M.tuberculosis_H37Rv GDWPARQPSTPAWFLDSARGVHQFLGRRRFVYPWVAWLVQRGAAPGDVLV MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 GAS----------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M -------------------------------------------------- Mb0104|M.bovis_AF2122/97 FTDDDTDKTIDLLIACHLAGCGYSVCDTADEISVRTNAITEHGDGILVTV Rv0101|M.tuberculosis_H37Rv FTDDDTDKTIDLLIACHLAGCGYSVCDTADEISVRTNAITEHGDGILVTV MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 --------YIMGTADPVEARNALAERLPAYMVPAAVVVLDALPLTVNGKL MSMEG_0402|M.smegmatis_MC2_155 --------YITGTADPAQLRTALAESLPAYMVPTAVVVLDTIPLTVNGKL MAV_3243|M.avium_104 --------YITGTADPAELRTQLGKRLPAYMVPAAVVVLESLPLTVNGKL TH_3730|M.thermoresistible__bu --------YITGTADPVQARAQLADRLPPYMVPAAIVVLESIPLTSNNKL Mflv_2697|M.gilvum_PYR-GCK --------YVTGEPQLRELRAWLGRRLPRYLMPNAIVAVDRIPLTAHGKI MMAR_0099|M.marinum_M --------YLVGSVDAGQARAALAQALPAYMVPAAVVVVDSLPLTVNGKL Mb0104|M.bovis_AF2122/97 VDVAATQLAVVGHDELRKVVDERVTQVTHDALLATKTAYIMPTSGTTGQP Rv0101|M.tuberculosis_H37Rv VDVAATQLAVVGHDELRKVVDERVTQVTHDALLATKTAYIMPTSGTTGQP MLBr_00484|M.leprae_Br4923 -----------------------ATPIPVADDSADPLALLIYTSGSTGAP MUL_1722|M.ulcerans_Agy99 -----------------------AGSAPGTDVSDDSLALLIYTSGSTGAP Mvan_2578|M.vanbaalenii_PYR-1 -------------------------VRAQFSADGDALSLLIYTSGSTGAP . . . MAB_4098c|M.abscessus_ATCC_199 DKRALPAPEYRSVGTDYRAPSGPVEKVLADIYAQVLGVDRVGVDESFFDL MSMEG_0402|M.smegmatis_MC2_155 DRRALPAPEYRSAANDYRAPSTPAEQILADVYAQVLGVERVGVDDSFFDL MAV_3243|M.avium_104 DKRALPAPEYHKRAGQYRAPSNHTEEILADIYAQVLGVERVGVDDSFFDL TH_3730|M.thermoresistible__bu DVRALPAPEYRATGAEYRAPGTPLEGLLAGIFAEVLGVERVGVDDSFFDL Mflv_2697|M.gilvum_PYR-GCK DEPALVALEPAADG-AATRPQTPTEVELAAVLAEVLGVGEIDVTADFLEL MMAR_0099|M.marinum_M DIRALPAPQYGATG-SYRAPASPVEEVLAGIYAQVLGLDRVAVDQSFFDL Mb0104|M.bovis_AF2122/97 KLVRISHGSLAVFCDAISRAYGWG---AHDTVLQCAPLTSDISVEEIFGG Rv0101|M.tuberculosis_H37Rv KLVRISHGSLAVFCDAISRAYGWG---AHDTVLQCAPLTSDISVEEIFGG MLBr_00484|M.leprae_Br4923 KGAMYLQSNVGKMWRRSD-GNWFG-PTAASITLNFMPMSHVMGRGILYGT MUL_1722|M.ulcerans_Agy99 KGAMYPRRNVATFWRKR---TWFEGGYEPSITLNFMPMSHVMGRQILYGT Mvan_2578|M.vanbaalenii_PYR-1 KGAMYPQHLVANSWRRLARSFWGDLGVFPAITLNFMPMSHVMGRGLLYGT . : : : MAB_4098c|M.abscessus_ATCC_199 GGDSILSMQVVSRARAAGVHCRPRDIFVEQTVSG---VAAVASLSDGRAG MSMEG_0402|M.smegmatis_MC2_155 GGDSILSMQVVARARAAGIQCRPRDIFVEQTVAG---VARVA-VAAGESH MAV_3243|M.avium_104 GGDSILSMQVVARARAAGVICRPRDVFVEQTVAR---LARVASDGADEEQ TH_3730|M.thermoresistible__bu GGDSILSMQVVARARAAGVQCRPRDIFVEQTVAR---LASVVKVSGGEPE Mflv_2697|M.gilvum_PYR-GCK GLDSIVALSVVQTARRRGVVMRAKLMLDCATVR---ELAAAIDDAGSGPP MMAR_0099|M.marinum_M GGDSILAIQVVARARAAGVVCRPRDVFTEQTVAGLATVAAVFDDANDDGG Mb0104|M.bovis_AF2122/97 AACGARLVRSAAMKTGDLAALVDDLVARETTIVD--LPTAVWQLLCADGD Rv0101|M.tuberculosis_H37Rv AACGARLVRSAAMKTGDLAALVDDLVARETTIVD--LPTAVWQLLCADGD MLBr_00484|M.leprae_Br4923 LGNGG---TAYFAARSDLSTLLEDLKLVRPTELN--FVPRIWETLYDE-- MUL_1722|M.ulcerans_Agy99 LCNGG---TAYFVVKSDLSTLFEDLALVRPTELT--FVPRVWDMVFDE-- Mvan_2578|M.vanbaalenii_PYR-1 LDAGG---TAYFAARSDLSTFLEDLALVRPTQLS--FVPRIWDTIHAE-- . * . MAB_4098c|M.abscessus_ATCC_199 IVDDGIGPVLATPIIHWLQGVPGPVDQFNQTIVLQAPVG----VTEDDVV MSMEG_0402|M.smegmatis_MC2_155 VVDEGVGPVVATPIMRWLREVDGPTGQFNQTVITQAPAG----VTEDDVV MAV_3243|M.avium_104 VVDEGIGPVQATPIMRWLQTVQGPIDDFNQTMVLAAPSG----VTADDVA TH_3730|M.thermoresistible__bu TVDDGTGAVVATPIMRWLRGVDGPTDQFNQTVVLQAPPGTDTAAAEADVV Mflv_2697|M.gilvum_PYR-GCK SADEGSGPIALLPNAHWLYEFGDP-RRLASTEALRLPRG----ITGPQIR MMAR_0099|M.marinum_M HAEDSVGEVVATPIMLWLQSLDGPLKEFNQTALLQAPAA----MSYGDVI Mb0104|M.bovis_AF2122/97 AIDAIGRSRLRQIVIGGEAIRCSAVDKWLESAASQGISLLSSYGPTEATV Rv0101|M.tuberculosis_H37Rv AIDAIGRSRLRQIVIGGEAIRCSAVDKWLESAASQGISLLSSYGPTEATV MLBr_00484|M.leprae_Br4923 --------------------SKRAVDRRLANSG----------------- MUL_1722|M.ulcerans_Agy99 --------------------FQSEVDRRLVDG------------------ Mvan_2578|M.vanbaalenii_PYR-1 --------------------VSQELERRPSDA------------------ MAB_4098c|M.abscessus_ATCC_199 VILQALLDRHATLRLRAE---SGDASGGWSLLVPDTGTVDARACLRVAES MSMEG_0402|M.smegmatis_MC2_155 VILQALLDRHATLRLRVED--TQEDTDEWSLLVPEAGAVGARECLRTVDA MAV_3243|M.avium_104 VVLQALLDRHPMLRLRVE----DDGAGGWNLQAPEPGSVRAADCLQSVDT TH_3730|M.thermoresistible__bu AVLQALIDRHPTLRMRAEGMTAGDGTDDWSLFIPEPGATSAREVMHTVDT Mflv_2697|M.gilvum_PYR-GCK ALLQSVVDAHPVLRTRLDR----AAMTLVDGGFDLP--LTEIEVGDEGSA MMAR_0099|M.marinum_M VSLQAVLDRHAMLRLQVDT----DATGRWLLHVPAPGCVDARKCVRAVTA Mb0104|M.bovis_AF2122/97 VATFLPIVCDQTTMDGALLRLGRPILPNTVFLAFGEVVIVGDLVADGYLG Rv0101|M.tuberculosis_H37Rv VATFLPIVCDQTTMDGALLRLGRPILPNTVFLAFGEVVIVGDLVADGYLG MLBr_00484|M.leprae_Br4923 --------------------------------SADRAAIKAEVMDEQRQS MUL_1722|M.ulcerans_Agy99 ---------------------------------ADRVALEAQVKAEIRND Mvan_2578|M.vanbaalenii_PYR-1 ----------------------------------------TEVIADLRRS MAB_4098c|M.abscessus_ATCC_199 LSDAELVAARSRLNPAAGAQLSAVWVP-------DSRQLALMIHHLAVDG MSMEG_0402|M.smegmatis_MC2_155 LTDDVLVEARNRLDPAAGAMVSAVWVR-------ETSQLVLMIHHLAVDG MAV_3243|M.avium_104 LSDAVLVAARSRLNPGAGVMVSAVWAS-------ETSQLALIIHHVAVDG TH_3730|M.thermoresistible__bu LTDEVLIAARSRLNPAAGVMLSAVWAR-------GSGQLVLMIHHLAVDG Mflv_2697|M.gilvum_PYR-GCK AVARHAAAALEHLDPQRGPLWGAVWLRGSDDADSTSSVLLLTAHVLAMDP MMAR_0099|M.marinum_M LSDDELVQARSRLDPSAGVMVSALWVT-------SSAQLALVIHHLAIDG Mb0104|M.bovis_AF2122/97 IDGDGFGTVTAADGSRRRAFATGDRVT-----------VDAEGFPVFSGR Rv0101|M.tuberculosis_H37Rv IDGDGFGTVTAADGSRRRAFATGDRVT-----------VDAEGFPVFSGR MLBr_00484|M.leprae_Br4923 LLGGRYIAAMTGSAPTSPELKHGVESL-----------LEMHLLEGYGST MUL_1722|M.ulcerans_Agy99 VLGGRYTSALTGSAPISDEMKAWVEEL-----------LDMHLVEGYGST Mvan_2578|M.vanbaalenii_PYR-1 LLGGRYVTAMTGSAPLSPEMRAFVENL-----------LDVHLIDGYGST . . : . MAB_4098c|M.abscessus_ATCC_199 VSWRILLEDLNIAWAQHHGGQPVQLPAGGTSFARWAALLDEHARSQDVVA MSMEG_0402|M.smegmatis_MC2_155 VSWRILLEDLNIAWAQHCTGQSIELPAGGTSFARWSALLAEHAKTDTVRD MAV_3243|M.avium_104 VSWRTLIEDLNIAWAQHHSGQPVALPAGGTSFARWSSLLAEHALTPAVVE TH_3730|M.thermoresistible__bu VSWRILVEDLNIAWAQHRTGQPIDLPANGTSFARWSALLADHARAPEVVE Mflv_2697|M.gilvum_PYR-GCK VSWQIVIGELDAGWHALAGGRAPAALGEHTGYRQWSNLLRERAESS---- MMAR_0099|M.marinum_M VSWRILLDDLNSVWEQHRSGEMAALPAGGTSFRRWAALLAEQAYSATAVD Mb0104|M.bovis_AF2122/97 KDAVVKISGKRVDIAEVTRRIAEDPAVSDVAVELHSGSLGVWFKSQRTRE Rv0101|M.tuberculosis_H37Rv KDAVVKISGKRVDIAEVTRRIAEDPAVSDVAVELHSGSLGVWFKSQRTRE MLBr_00484|M.leprae_Br4923 EAGMVLFDG----------------------------------------- MUL_1722|M.ulcerans_Agy99 EAGMILIDG----------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 EAGAVFVDG----------------------------------------- . MAB_4098c|M.abscessus_ATCC_199 TADAWREVTAVPAALPAVMPGLDTYATAKTLSVSLDADTTRELLSEVPAA MSMEG_0402|M.smegmatis_MC2_155 LADAWRAVTSVPQALPPVQPDTDTYVTAGQLSASLDVETTRQLLGEVPAA MAV_3243|M.avium_104 QADAWREVVATPAVLPAVQPEVDTYQSAEQLSVSLDVDTTRLLLGEVPAA TH_3730|M.thermoresistible__bu HVEAWQRVIAAPSALPAIRPERDTYATAGQLSVSLDADTTRQLLGAVPAA Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M HAAAWRQVLATPSVLPAVKPAVDTYATAQRLLVSLDIETTRTLLAAAPAA Mb0104|M.bovis_AF2122/97 GEQDAAAATRIRLVLVSLGVSSFFVVGVPNIPRKPNGKIDSDNLPRLPQW Rv0101|M.tuberculosis_H37Rv GEQDAAAATRIRLVLVSLGVSSFFVVGVPNIPRKPNGKIDSDNLPRLPQW MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 FHAGVQDILLIAFGLAWNEFLDSNTTSIGIGVEGHGRQEELGRVAGLDID MSMEG_0402|M.smegmatis_MC2_155 FRAGVQDILLVAFGLAWTEFLNRSDTPIGVDVEGHGRYDEL----ASDVD MAV_3243|M.avium_104 FHAGVQDILLIAFAMAWTQVVGAG-TPIGIDVEGHGRHEELG----PHVD TH_3730|M.thermoresistible__bu FHAGVQDILLIAFGLAWAEFLGACDSPIGIDVEGHGRAEELA----AGVD Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M FHAGVQDILLIAFALAWSEFSSGGGSRIAIDVEGHGRHEELA----FGVD Mb0104|M.bovis_AF2122/97 SAAGLNTAETGQRAAGLSQIWSRQLGRAIGPDSSLLGEGIGSLDLIRILP Rv0101|M.tuberculosis_H37Rv SAAGLNTAETGQRAAGLSQIWSRQLGRAIGPDSSLLGEGIGSLDLIRILP MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 LSRTVGWFTTKYPVSLSVGGLSWKEIADGSPDLGPIIKSAKEQLRALPDP MSMEG_0402|M.smegmatis_MC2_155 LSRTVGWFTTKYPVALTVENLPWEQVVAGDAALGGIVKAVKEQLRSLPEG MAV_3243|M.avium_104 LSRTVGWFTTKYPVALAIDGLDWASVVAGDDALGAAVKAAKEQLRALPDG TH_3730|M.thermoresistible__bu LSRTVGWFTTKYPVALTIPKLSWEQVRTGGDALGAAVKAAKEQLRSVPDG Mflv_2697|M.gilvum_PYR-GCK ------------------------------------------------DG MMAR_0099|M.marinum_M LSHTLGWFTTKYPVAVSVGALRWAQVVAGDAALGAVVKDAKEQLRGLPDG Mb0104|M.bovis_AF2122/97 ETRRYLGWRLSLLDLIGADTAANLADYAPTPDAPTGEDRFRPLVAAQRPA Rv0101|M.tuberculosis_H37Rv ETRRYLGWRLSLLDLIGADTAANLADYAPTPDAPTGEDRFRPLVAAQRPA MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 LTYGLLRYLNPDVDLSGPEPAIGFNYLGRLGAGAADLTDDLWRINEDSLS MSMEG_0402|M.smegmatis_MC2_155 LTYGLLRYLNPEVDLGGSDPTIGFNYLGRLGAGAGELSEELWRIDQDSLA MAV_3243|M.avium_104 LTYGLLRYLNPDVDLGGSDPVIGFNYLGRLGA-AADLPGELWRLSPDSLS TH_3730|M.thermoresistible__bu ITYGLLRHLNPDVELGGAEPAIGFNYLGRLAAGAGDLPDELWRIDPSGLP Mflv_2697|M.gilvum_PYR-GCK LQFWLD-------QLGGPDPALGARRVR---------------------- MMAR_0099|M.marinum_M LLYGLIRYLNREVELAGAEPTIGFNYLGRLSTRTTAGDDHWQIARWGSLF Mb0104|M.bovis_AF2122/97 AIPLSFAQRRLWFLDQLQRPAPVYNMAVALRLRGYLDTEALGAAVADVVG Rv0101|M.tuberculosis_H37Rv AIPLSFAQRRLWFLDQLQRPAPVYNMAVALRLRGYLDTEALGAAVADVVG MLBr_00484|M.leprae_Br4923 ---------------EVQRPPVIDYKLVDVPDLGYFSTDQPYPRGELLLK MUL_1722|M.ulcerans_Agy99 ---------------AIRRPAVLDYKLVDVPDLGYFLTDRPHPRGELLVK Mvan_2578|M.vanbaalenii_PYR-1 ---------------RVQRPPVIDYKLVDVADLGYFSTDRPHPRGELLVK * MAB_4098c|M.abscessus_ATCC_199 SAGVAS-SVSMPLMYTVDLNAGIVEGGLGEEAGPHLRAGWTWAPSSVTEP MSMEG_0402|M.smegmatis_MC2_155 LSDAAS-AVPMPLMHTVELNAGTID----TDNGPSLRASWTWAPSAFDEE MAV_3243|M.avium_104 LSGAAA-AVAMPLMHTVDLNAGTMD----TEDGPHLHANWTWAPSAVDRD TH_3730|M.thermoresistible__bu ITEAAS-KIPMPLAHTVEVNAGTLDAG---PDGPVLQATWTWAPSLVDEA Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M TDECASAELPIQLFHTVELDAVTFD----TEAGPQLHAQWTWATSALDRA Mb0104|M.bovis_AF2122/97 RHESLR-------------------------------------------- Rv0101|M.tuberculosis_H37Rv RHESLR-------------------------------------------- MLBr_00484|M.leprae_Br4923 TQNMFP-------------------------------------------- MUL_1722|M.ulcerans_Agy99 TDSLFP-------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 SETLFP-------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 QVQRLSQLWFEALAGICAYVRGGGGGLTPSDIAPAQLSQQQIDELHEQHK MSMEG_0402|M.smegmatis_MC2_155 QATRLSRLWFEALAGICAHVRGGGGGLTPSDVAPARLTQRQIDELSQRYD MAV_3243|M.avium_104 QISRLSQLWFEALAGICAHVRAGGGGLTPSDILPARLNQRQIDELSKQHQ TH_3730|M.thermoresistible__bu QIARLSRLWFEALGGVCAHVRSGGGGLTPSDIAPARLTQQQIDELADRHD Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M QLNRISRLWFEALTGICAHVRAGGGGMTPSDIGLTRLSQHQIDQLEQRYC Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 IVDVLPLTPIQEGLLFHTTFARAAGALEGDEAGIDFYAVQLDITVTGLVD MSMEG_0402|M.smegmatis_MC2_155 VTDVLPLTPVQQGLLFHSTFARGIG--------DDVYAVQLDITITGVLD MAV_3243|M.avium_104 IADILPLTPLQQGLLFHASFAQDPG--------DDVYAVQLGITVTGALD TH_3730|M.thermoresistible__bu IADILPLTPVQQGLLFHSAVTRTTA--------DDIYAVQLDLTIAGVVD Mflv_2697|M.gilvum_PYR-GCK -----------------PDTDRAGD-------------VRVTVTVTGADV MMAR_0099|M.marinum_M VADVLPLTPLQQGLLFHADAARGGAD---------LYVVQFDITLSGALD Mb0104|M.bovis_AF2122/97 -----------------TVFPAVDGVPRQLVIEARRADLGCDIVDATAWP Rv0101|M.tuberculosis_H37Rv -----------------TVFPAVDGVPRQLVIEARRADLGCDIVDATAWP MLBr_00484|M.leprae_Br4923 -----------------GYYKRPE-------------------VTATVFD MUL_1722|M.ulcerans_Agy99 -----------------GYYQRAE-------------------VTADVFD Mvan_2578|M.vanbaalenii_PYR-1 -----------------GYYKRPD-------------------VTAEMFD . : MAB_4098c|M.abscessus_ATCC_199 QLRLRDAVHTVVRRHPNLAAR--FCTQFGDPVQVILADPVIAWRYLDLRG MSMEG_0402|M.smegmatis_MC2_155 QHRLRDAVHTVVARHPNLAAR--FVEQFGEPVQVLTADPMIAWRYLDLRG MAV_3243|M.avium_104 SHRLHDAVHTVVNRHPNLAAR--FCPQYGEPVQVVPADPVMAWRYIQLGP TH_3730|M.thermoresistible__bu QHRLRDAVHAVVARHPNLAAR--FCTDHDHPVQIIPTEPVAAWRYLDLRG Mflv_2697|M.gilvum_PYR-GCK TARLLAGPHPVLD------------------------------------- MMAR_0099|M.marinum_M PRRLRTAAQEVLRRHPNLAAQFVWGEPLDEPVQIILNDLVLEWRTVEFDP Mb0104|M.bovis_AF2122/97 ADRLQRAIEEAARHSFDLATEIPL-------------------------- Rv0101|M.tuberculosis_H37Rv ADRLQRAIEEAARHSFDLATEIPL-------------------------- MLBr_00484|M.leprae_Br4923 SDGYYQTGDIVAEVGPDRLVYVDR-------------------------- MUL_1722|M.ulcerans_Agy99 ADGFYRTGDIMAEVGPEQFVYLDR-------------------------- Mvan_2578|M.vanbaalenii_PYR-1 EDGYYRTGDIVAETGADQLTYLDR-------------------------- . MAB_4098c|M.abscessus_ATCC_199 D---DLTPDEEIQHLCAAERAAVCDLADRPTLRAALIRTEGNQHRFVLTF MSMEG_0402|M.smegmatis_MC2_155 D---DLTPDHEIEQLCAAERSAVCDLLERPTFRAALIRTSGNQHRFVLTF MAV_3243|M.avium_104 E---DVDPEQKVEELCAAERAAVSDLANRPAFRAALIRTADNRHRFVLTN TH_3730|M.thermoresistible__bu D---DQNPEHEVQQLCAAERAAVRDLTERPTFRAALIRTGATEHRFVLTV Mflv_2697|M.gilvum_PYR-GCK --------------------VLVAALG----------------------- MMAR_0099|M.marinum_M AGDPDAHVEQHIDEVCADERVAVADLGGGSPFRIALIRTAPCEHRLVLTA Mb0104|M.bovis_AF2122/97 --------RTWLFRIADDEHVLVAVAHHIAADGWSVAPLTADLSAAYASR Rv0101|M.tuberculosis_H37Rv --------RTWLFRIADDEHVLVAVAHHIAADGWSVAPLTADLSAAYASR MLBr_00484|M.leprae_Br4923 --------RNNVLKLAQGQFVTVAKLEAAFSN------------------ MUL_1722|M.ulcerans_Agy99 --------RNNVLKLSQGEFVTVSKLEAVFGD------------------ Mvan_2578|M.vanbaalenii_PYR-1 --------RNNVLKLSQGEFVTVSRLEAVFGN------------------ * MAB_4098c|M.abscessus_ATCC_199 HHVVIDGWSLPILLQEIFASYFGHRLPAPSSYRSFVSWLADQDLDAARTA MSMEG_0402|M.smegmatis_MC2_155 HHIVIDGWSLPILLQEIFAGYFGHRLPAAAPYRNFVNWLATQDATAAKAA MAV_3243|M.avium_104 HHIVMDGWSLPILLREILAIYYGDQLPAPATYRSYLTWLAGQDRSAAQAA TH_3730|M.thermoresistible__bu HHIVIDGWSLPILLQEIFAGYFGQRLPAPARFRDFVTWLAAQDRDAARAA Mflv_2697|M.gilvum_PYR-GCK --------------------------------RTITEWRGRRNQPTP--- MMAR_0099|M.marinum_M HHIVCDGWSMPIVMQEILAAYAGQPLAAPGSYRNFLTWLAERDKSAARTA Mb0104|M.bovis_AF2122/97 CAGRAPDWAPLPVQYVDYTLWQREILGDLDDSDSPIAAQLAYWENALAGM Rv0101|M.tuberculosis_H37Rv CAGRAPDWAPLPVQYVDYTLWQREILGDLDDSDSPIAAQLAYWENALAGM MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 WGKVLEGFDTPTLVAPPAPP--GARGVESYRVSAETTQALGDLARSQHTT MSMEG_0402|M.smegmatis_MC2_155 WREVLDGFETPTLVAPPGVP--GPRGIESYRVSAETTRALGELARSQHTT MAV_3243|M.avium_104 WRQVLDGFDTPTLVGPAGRMRLGRRAVESYRLSADTTRALGELARACHTT TH_3730|M.thermoresistible__bu WRELLDGFDTPTLIAPPGQA--GPRGSASYRIDTETTAAIGELARTQRTT Mflv_2697|M.gilvum_PYR-GCK ----------PPLVALETHG------------------------------ MMAR_0099|M.marinum_M WRELFADFRHPTLVGLPDHLGLGSRGVESYLLPIGITEALTELARSCRVT Mb0104|M.bovis_AF2122/97 PERLRLPTARPYPPVADQRG-------ASLVVDWPASVQQQVRRIARQHN Rv0101|M.tuberculosis_H37Rv PERLRLPTARPYPPVADQRG-------ASLVVDWPASVQQQVRRIARQHN MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 VSTVLQAAWAQLLMVLTGQDDVAFGTAVSGRPAELAGSDSIVGLLINTVP MSMEG_0402|M.smegmatis_MC2_155 INTVLQAAWTQLLMRMTGQRDVAFGTAVSGRPADLAGAESMVGLLINTVP MAV_3243|M.avium_104 VNTVLQAGWAQLLMRLTGQHDVAFGTAVSGRPADLAGAESMVGLLINTVP TH_3730|M.thermoresistible__bu VNTVLQAAWAHLLMAMTGQRDVVFGTAVSGRPADLPGADRIVGLLINTIP Mflv_2697|M.gilvum_PYR-GCK --------------------RAALAEADTADTADTADTSDTVGLLSAIYP MMAR_0099|M.marinum_M VNIVLQAAFAQLLSWLTGQHDVAFGTTVSGRPAEVAGVHSMVGLFINTVP Mb0104|M.bovis_AF2122/97 ATSFMVVAAGLAVLLSKLSGSPDVAVGFPIAGRSDPALDNLVGFFVNTLV Rv0101|M.tuberculosis_H37Rv ATSFMVVAAGLAVLLSKLSGSPDVAVGFPIAGRSDPALDNLVGFFVNTLV MLBr_00484|M.leprae_Br4923 ----------------------------------------------SPLV MUL_1722|M.ulcerans_Agy99 ----------------------------------------------SPLV Mvan_2578|M.vanbaalenii_PYR-1 ----------------------------------------------SPLV MAB_4098c|M.abscessus_ATCC_199 VRARATASTTIAELLGQLQS-----------AHNDTIEHEHLALNEIHHV MSMEG_0402|M.smegmatis_MC2_155 IRAKVSADTTVGDLLRQLQS-----------HHNDTLEHEHLALNDIHHV MAV_3243|M.avium_104 VRANTHAETTVADLLDQLQQ-----------HHNDTLEHEHLALSEIHRV TH_3730|M.thermoresistible__bu VRARIGADTTVADLLAQLQH-----------AHNDTLEHEHLALTEIHHL Mflv_2697|M.gilvum_PYR-GCK LRLHEDSPGATTELIAGVPAGG---------IDYGLLRYLRPDTS----- MMAR_0099|M.marinum_M TRARMASTTTTRELLDQLQS-----------VHYETLEHHHLALSDIHRV Mb0104|M.bovis_AF2122/97 LRVNLAGDPSFAELLGQVRARSLAAYENQDVPFEVLVDRLKPTRALTHHP Rv0101|M.tuberculosis_H37Rv LRVNLAGDPSFAELLGQVRARSLAAYENQDVPFEVLVDRLKPTRALTHHP MLBr_00484|M.leprae_Br4923 RQIYIYGNSAHPYLLAVVVP------------------------------ MUL_1722|M.ulcerans_Agy99 RQIYIYGNSARAYLLAVIVP------------------------------ Mvan_2578|M.vanbaalenii_PYR-1 RQIYVYGNSARPYLLAVVVP------------------------------ : . : *: : MAB_4098c|M.abscessus_ATCC_199 AGHEQLFDTLFLYESYPIDTSAFMGVQELAITEFVTREYNHYPLSVMALP MSMEG_0402|M.smegmatis_MC2_155 SGHEQLFDTLFLYESYPIDTSAFMGVQELAVTEFNNREYNHYPLSVMALP MAV_3243|M.avium_104 TGHDALFDTLFLYENYPIDTSVPLGFHELAITDVTNREYNHYPLSVMALP TH_3730|M.thermoresistible__bu AGHDQLFDTLFLYESYPIDTGAFSGAQELAVTGFTNREFNHYPLSVMALP Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------EVLKAHP MMAR_0099|M.marinum_M SGHDQLFDTLFVYENYPIDKTAAQGTGELAISGIGCREYSHYPLVVQAMP Mb0104|M.bovis_AF2122/97 LIQVMLAWQDNPVGQLNLGDLQATPMPIDTRTARMDLVFSLAERFSEGSE Rv0101|M.tuberculosis_H37Rv LIQVMLAWQDNPVGQLNLGDLQATPMPIDTRTARMDLVFSLAERFSEGSE MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 GHELGIRVEYDTDKFGLDDIQAVFERFERVLVSMVSDADQRLSSLDVLQT MSMEG_0402|M.smegmatis_MC2_155 GHELGLRVEYDTSVFDVSEIETLIDRFQRLLEAMIDDPARRLSSMDVVDD MAV_3243|M.avium_104 GRELGLRVEFDTDVFDAAGIEKLTERFQRVLSEMTADPTRRLTSLEVMDE TH_3730|M.thermoresistible__bu GHELGLRIEYDTEVFDTAAIDALADRFRRVLESMVGDPARRLSAIEVLDA Mflv_2697|M.gilvum_PYR-GCK EPQILLNYLGRTDLVPSGAIVADRLLLS------------GLSTVPEPNA MMAR_0099|M.marinum_M GDQLGLRVEFRTDVFDAASIAALIQRLQRVVVAMVADPDRRLSSVDLLDA Mb0104|M.bovis_AF2122/97 PAGIGGAVEYRTDVFEAQAIDVLIERLRKVLVAVAAAPERTVSSIDALDG Rv0101|M.tuberculosis_H37Rv PAGIGGAVEYRTDVFEAQAIDVLIERLRKVLVAVAAAPERTVSSIDALDG MLBr_00484|M.leprae_Br4923 ----------TEDALATNDIEVLKPLIIDSLQKVAKEAD----------- MUL_1722|M.ulcerans_Agy99 ----------TQEALDAVPVEELKARLGDSLQEVAKAAG----------- Mvan_2578|M.vanbaalenii_PYR-1 ----------TEAALAG---ADAKAAVAESLQDVAKATG----------- . . MAB_4098c|M.abscessus_ATCC_199 DEHKQLDGWGNRKVLVRGPEPVLSIPEAFAEQVDRAPEAVALTFEGRSTT MSMEG_0402|M.smegmatis_MC2_155 DERTQLDEWANRAVLTQPVDSPQSIPEVFARQVERDPEAPAVTFEGESLN MAV_3243|M.avium_104 AEHELLDAWGNRPVLSQPATG-TSIPALFAAQVARTPDAAALTFQGRSMS TH_3730|M.thermoresistible__bu AEREQLDAWSNRAVLAD-SPALESIPEVFARQVARDPGAVAVTFEGRSMT Mflv_2697|M.gilvum_PYR-GCK AVRHELTVV---------------------AAVVAHGDEPALVAQWRVLP MMAR_0099|M.marinum_M AEHARLDVVGNRAVLAEPLVEPVSVPGLFAAQVASRAEVTALVCGDRSLT Mb0104|M.bovis_AF2122/97 TERARLDEWGNRAVLTAPAPTPVSIPQMLAAQVARIPEAEAVCCGDASMT Rv0101|M.tuberculosis_H37Rv TERARLDEWGNRAVLTAPAPTPVSIPQMLAAQVARIPEAEAVCCGDASMT MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 YGELDEAANRLANLLSVYGAAPGESVALLMPRSDEAIIAILAILKTGASY MSMEG_0402|M.smegmatis_MC2_155 YGELDEAANQLANLLAVYGAAPGKSVALMVPRSADAIVAILAVLKTGAAY MAV_3243|M.avium_104 YRELDEASNRLAHLLIEEGAGPGECVALLFSRSAEAIVSILAVLKTGAAY TH_3730|M.thermoresistible__bu YGELDDAATELANLLAVYGAGPGESVALLMPRSADAIVAILAVLKTGAAY Mflv_2697|M.gilvum_PYR-GCK EILSDTDVEEMQTIWQDT---------------------LREVL------ MMAR_0099|M.marinum_M YRELDRAANRLAHLLVDQGVGPGDVVGLLLERSVEAVIAILAVLKSGAAY Mb0104|M.bovis_AF2122/97 YRELDEASNRLAHRLAGCGAGPGECVALLFERCAPAVVAMVAVLKTGAAY Rv0101|M.tuberculosis_H37Rv YRELDEASNRLAHRLAGCGAGPGECVALLFERCAPAVVAMVAVLKTGAAY MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 LPIDPSVPDTRLEFMLSDAVPIAAVTTAELRARFDGSGVS-----VVQFD MSMEG_0402|M.smegmatis_MC2_155 LPIDPSVPAARLEFMLGDAKPVAAVTTGDLRSRFDGFDLQ-----VVEVD MAV_3243|M.avium_104 LPIDPALPAARIEFLLGDAEPVAVVTTAALRSRLDGCKPS-----VVDVD TH_3730|M.thermoresistible__bu LPIDPAVPAARLEFMLSDAEPIVALTTVELGTRFNGTGVP-----IIEVD Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M LAIDVNHPDGRIGFMIEDAAPVAVITTAGLAQRLAGYPVA-----VIDID Mb0104|M.bovis_AF2122/97 LPIDPANPPPRVAFMLGDAVPVAAVTTAGLRSRLAGHDLPIIDVVDA--- Rv0101|M.tuberculosis_H37Rv LPIDPANPPPRVAFMLGDAVPVAAVTTAGLRSRLAGHDLPIIDVVDA--- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 DAEDDPTGAIYGHTPLLTPAPDDIAYTIYTSGTTGVPKGVAIAHSNVTQA MSMEG_0402|M.smegmatis_MC2_155 ----DPAVEIYPSTTLLTPSPDDIAYMIYTSGTTGVPKGVAITHGNVTQV MAV_3243|M.avium_104 ----DPALDGQPSAALPVPSSDNIAYLIYTSGTTGVPKGVAVSHDNVAQL TH_3730|M.thermoresistible__bu ----DPAPPMYPSSTLLPPAPDDIAYLIYTSGTTGVPKGVAITHANVTRV Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M DP---AIATCYPGHGLPFPSADNIAYLIYTSGTTGKPKGVGITHHNITQL Mb0104|M.bovis_AF2122/97 -------LAAYPGTPPPMPAAVNLAYILYTSGTTGEPKGVGITHRNVTRL Rv0101|M.tuberculosis_H37Rv -------LAAYPGTPPPMPAAVNLAYILYTSGTTGEPKGVGITHRNVTRL MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 LKFPLTH-MPTGPGEVWTQAGSLVFDITVWEIFGALLHGGRLVIIPDSVV MSMEG_0402|M.smegmatis_MC2_155 LDTLPAE-LPAGPGAVWSQWHSLVFDVSVWEIWGALLHGGRLVIVPESIA MAV_3243|M.avium_104 VESLHAD-LPEG--GVWAQWHSLVFDVSVHEIWGALLHGGRLVVVPESVA TH_3730|M.thermoresistible__bu LHTLPAD-LPAGPGKVWSQWHSLVFDVSVWEIWGALLHGGRLVIVPESIT Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M FTSVAATGFTPAPGQIWTQCHSYAFDLSVFEMWGALLHGGRLVVVPESVT Mb0104|M.bovis_AF2122/97 FASLPAR---LSAAQVWSQCHSYGFDASAWEIWGALLGGGRLVIVPESVA Rv0101|M.tuberculosis_H37Rv FASLPAR---LSAAQVWSQCHSYGFDASAWEIWGALLGGGRLVIVPESVA MLBr_00484|M.leprae_Br4923 -------------LQSYEVPRDLIVETTPFSLENGLLTGIRKLAWPK--- MUL_1722|M.ulcerans_Agy99 -------------LQSYEIPRDFIIETTPWTLQNGLLTGIRKLARPQ--- Mvan_2578|M.vanbaalenii_PYR-1 -------------LQSYEIPRDFLLETTPFTLENGLLTGIRKLARPR--- MAB_4098c|M.abscessus_ATCC_199 RSPDDFRDLLIREKVTVLFQTPSAVGMLSPEGLNNLTLVVAGEACPTEVV MSMEG_0402|M.smegmatis_MC2_155 GSPDDLHALLVSEGVNVLYQTPSAVRMMSPEGLEGTALVVAGEACPTEVV MAV_3243|M.avium_104 ASPDELHDLLVAEGVTVLSQTPSAVGMLSPEGLDSTALVVAGEACPVEIV TH_3730|M.thermoresistible__bu GSPDDLHDLLVAEHVDVVYQTPSAAGMLSQRGLDSTALVVAGEACPTDLV Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M GSPADLHALLVAEQVDVLAQTPSAVAMLSTQGLESTTLVVGGEACPAEVV Mb0104|M.bovis_AF2122/97 ASPNDFHGLLVAEHVSVLTQTPAAVAMLPTQGLESVALVVAGEACPAALV Rv0101|M.tuberculosis_H37Rv ASPNDFHGLLVAEHVSVLTQTPAAVAMLPTQGLESVALVVAGEACPAALV MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 DRWAPGRVMINGYGPTETTIYATFG-ELIAGSGVVPIGVPVPDAALFVLD MSMEG_0402|M.smegmatis_MC2_155 DRWAVDRVMINAYGPTESTIYAAISAPLSPGSDVVPIGSPVPKGATFVLD MAV_3243|M.avium_104 DRWAPGRVMINAYGPTEATVYAAMSTPLQPGTGSAPIGSPVPRAALFVLD TH_3730|M.thermoresistible__bu DRWAPGRVMINAYGPTETTMCVAISAPLTPGSGAVPIGTPVPRAALFVLD Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M DNWAPGRMMVNQYGPSETTMYVSMSAPLVPGSGPAPIGVPVPRAALFVLD Mb0104|M.bovis_AF2122/97 DRWAPGRVMLNAYGPTETTICAAISAPLRPGSGMPPIGVPVSGAALFVLD Rv0101|M.tuberculosis_H37Rv DRWAPGRVMLNAYGPTETTICAAISAPLRPGSGMPPIGVPVSGAALFVLD MLBr_00484|M.leprae_Br4923 --------LKQHYGARLEQLYADLVE------------------------ MUL_1722|M.ulcerans_Agy99 --------LKKHYGELLEQIYTDLAH------------------------ Mvan_2578|M.vanbaalenii_PYR-1 --------LRERYGEQLEALYTMLSE------------------------ MAB_4098c|M.abscessus_ATCC_199 RWMRPVPPGVVGELYVAGLGVGIGYVKRQALTAARFVACPFGEPGTRMYR MSMEG_0402|M.smegmatis_MC2_155 EWLRPVPPGVVGELYLAGRGVGVGYVGRSGLTGTRFVACPFGEPGARMYR MAV_3243|M.avium_104 RWLRPAPPGVVGELYIAGHGVATGYARRSGLTASRFVACPFGGPGARMYR TH_3730|M.thermoresistible__bu SWMRPVPAGVIGELYVAGDGVAVGYVGRSELTASRFVACPFGPPGSRMYR Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M GWLRPVPAGVAGELYVAGAGVGCGYWRRSGLTASRFVACPFGALGARMYR Mb0104|M.bovis_AF2122/97 SWLRPVPAGVAGELYIAGAGVGVGYWRRAGLTASRFVACPFGGSGARMYR Rv0101|M.tuberculosis_H37Rv SWLRPVPAGVAGELYIAGAGVGVGYWRRAGLTASRFVACPFGGSGARMYR MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 TGDLVRWGVSESSVGQLEYLGRADEQVKIRGFRIELGEIQAALADVDGVE MSMEG_0402|M.smegmatis_MC2_155 TGDLVRWGDD----GQLQYLGRADEQVKIRGYRIELGEIQAALSDVDGVD MAV_3243|M.avium_104 TGDLVRWNQD----GQLEYLGRADEQVKLRGYRIELGEVQAALAGLDGVE TH_3730|M.thermoresistible__bu TGDLVRWGAD----GQLQYLGRADEQVKIRGYRIELGEVQTALTAVDGVE Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M TGDVVRWGPD----GQLQYVGRADEQVKIRGYRIELGEVAAALSQLDGVD Mb0104|M.bovis_AF2122/97 TGDLVCWRAD----GQLEFLGRTDDQVKIRGYRIELGEVATALAELAGVG Rv0101|M.tuberculosis_H37Rv TGDLVCWRAD----GQLEFLGRTDDQVKIRGYRIELGEVATALAELAGVG MLBr_00484|M.leprae_Br4923 --------------------GQANALHVLK----------------QSVA MUL_1722|M.ulcerans_Agy99 --------------------GQADELRSLR----------------QSGA Mvan_2578|M.vanbaalenii_PYR-1 --------------------EQADELRELR----------------RSGG MAB_4098c|M.abscessus_ATCC_199 QAAVIAREDRPGDKRLVGYFIGTGE----PAELRAALAKRLPPYMVPAAL MSMEG_0402|M.smegmatis_MC2_155 QAVVIAREDRPGDKRLVGYITGTAD----PAAARSELTNRLPAYMVPAAV MAV_3243|M.avium_104 QAAVIAREDRPGDKRLVGYITGTAD----PVGIRIQLAERLPAYMVPAAV TH_3730|M.thermoresistible__bu NAVVIAREDRPGDKRLVGYITGTAD----PDQARARLADRLPAYMVPTAV Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M QAVVIAREDRPGDKRLVGYLVGSVD----AGQARAALAQALPAYMVPAAV Mb0104|M.bovis_AF2122/97 QAVVIAREDRPGDKRLVGYATEIAPGAVDPAGLRAQLAQRLPGYLVPAAV Rv0101|M.tuberculosis_H37Rv QAVVIAREDRPGDKRLVGYATEIAPGAVDPAGLRAQLAQRLPGYLVPAAV MLBr_00484|M.leprae_Br4923 NAPVLQTVSRAVGTILGVATTDLPS------------------------- MUL_1722|M.ulcerans_Agy99 DAPVLVTVCRAAAALLGGSASDVQP------------------------- Mvan_2578|M.vanbaalenii_PYR-1 ERPALETVGRAAGALLGTTAGELEP------------------------- MAB_4098c|M.abscessus_ATCC_199 VRLEALPLTVNGKLDKRALPAPEYDD-AARYRAPANAVEEAVAGIYAQVL MSMEG_0402|M.smegmatis_MC2_155 VTLETLPLTVNGKLDRRALPAPEYQS-AQRYRAPETETEKTLAGIFAHVL MAV_3243|M.avium_104 VVLDALPLTVNGKLDKRALPAPEYRKRGGEYIAPTNPTEETVAGIFARVL TH_3730|M.thermoresistible__bu VVLDALPLTVNGKLDTRALPAPEYQD-AEQYRAPTHAVEEVLAGIYAEVL Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M VVVDSLPLTVNGKLDIRALPAPQYGA-TGSYRAPASPVEEVLAGIYAQVL Mb0104|M.bovis_AF2122/97 VVIDALPLTVNGKLDHRALPAPEYGD-TNGYRAPAGPVEKTVAGIFARVL Rv0101|M.tuberculosis_H37Rv VVIDALPLTVNGKLDHRALPAPEYGD-TNGYRAPAGPVEKTVAGIFARVL MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_4098c|M.abscessus_ATCC_199 GVERVGTDDSFFDLGGDSISAMRVVAAINTSFDAQLAVRTLFEAPSVRSL MSMEG_0402|M.smegmatis_MC2_155 GVERIGLDDSFFDLGGDSISAMRVTAAVNTALDADLSVRTLFEAPTVAKL MAV_3243|M.avium_104 GMERVSIDDSFFELGGDSLSAMRVIAEINTAVDGALSVRTLFDSQSVRAL TH_3730|M.thermoresistible__bu GIDKVGVDDSFFDLGGDSISSMQVVARARAAGLTIRPRDIFVERTVARLA Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M GLDRVAVDQSFFDLGGNSILAMRVSSAIEKFLGVDLPVRLMFEAPTVESL Mb0104|M.bovis_AF2122/97 GLERVGVDDSFFELGGDSLAAMRVIAAINTTLNADLPVRALLHASSTRGL Rv0101|M.tuberculosis_H37Rv GLERVGVDDSFFELGGDSLAAMRVIAAINTTLNADLPVRALLHASSTRGL MLBr_00484|M.leprae_Br4923 -------NAHFTDLGGDSLSALTFGSLLRELFDIDVPVGVIVSPVNNLVA MUL_1722|M.ulcerans_Agy99 -------DAHFTDLGGDSLSALSFTNLLHEIFDIDVPVGVIVSPANDLQA Mvan_2578|M.vanbaalenii_PYR-1 -------SAHFTDLGGDSLSALTFANLLRDIFDVDVPVGVIVSPATDLQA MAB_4098c|M.abscessus_ATCC_199 SGYLDGAAGAP-ANGPTYASVHGP---GATEVRASDLTLDKFIDEATLQK MSMEG_0402|M.smegmatis_MC2_155 SLHVEHDAGER-TDRVSFAAVHGS---DVTEVHARDLTLDKFIDAPTLRT MAV_3243|M.avium_104 SQRITSGADAENAAGPGFAAVHGA---DAKEVYARDLTLDKFLDATTLST TH_3730|M.thermoresistible__bu QVAVPTGADAAVDDAGTGPVVATP---IMRWLYDTRGPIDQFNQTVVLRA Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M SRQVESPYSSVELAPVELLKQGAG---TPLFCLPPGGGLSWIYRNLGAYL Mb0104|M.bovis_AF2122/97 SQLLGRDARP--TSDPRLVSVHGD---NPTEVHASDLTLDRFIDADTLAT Rv0101|M.tuberculosis_H37Rv SQLLGRDARP--TSDPRLVSVHGD---NPTEVHASDLTLDRFIDADTLAT MLBr_00484|M.leprae_Br4923 IADYIERERQ-GTKRPTFIAIHGR---DAGKVHASDLTLDKFIDVSTLTA MUL_1722|M.ulcerans_Agy99 LADYVEAARKPGSSRPTFASVHGASNEQVTEVHAGDLSLDKFIDAATLAE Mvan_2578|M.vanbaalenii_PYR-1 LADYVESARRHGSVRPTFESVHGHSGRPGTEVHARDLTLDEFVDAATLAH MAB_4098c|M.abscessus_ATCC_199 APTLPRAEATARTVLLTGATGFLGRYLVLQWLRELEQVDGTLICLVRAKS MSMEG_0402|M.smegmatis_MC2_155 ATTLPRPDGAVQTVLLTGATGFLGRYLLLEWLRQLRRVDDKVICLVRGKS MAV_3243|M.avium_104 APTLPGPSPEVRTVLLTGATGFLGRYLVLEWLEQLEQVDGKLICLVRARS TH_3730|M.thermoresistible__bu PAGVT--EADVVEILQA----------VLDRHAMLRLRAADVENLTVPES Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M DCPIIG---------------------IQQVPSDQEVEPGSVGDMARRYV Mb0104|M.bovis_AF2122/97 AVNLPGPSPELRTVLLTGATGFLGRYLVLELLRRLDVDG-RLICLVRAES Rv0101|M.tuberculosis_H37Rv AVNLPGPSPELRTVLLTGATGFLGRYLVLELLRRLDVDG-RLICLVRAES MLBr_00484|M.leprae_Br4923 APVLAQPGTEVRTVLLTGATGFLGRYLALKWLERMDLVEGKVIALVRAKS MUL_1722|M.ulcerans_Agy99 APRLPAANTQVRTVLLTGATGFLGRYLALEWLERMDLVDGKLICLVRAKS Mvan_2578|M.vanbaalenii_PYR-1 APTLPGPRAEVRTVLLTGATGFLGRYLALEWLERMALVGGKLICLVRAKD MAB_4098c|M.abscessus_ATCC_199 DEEARRRLDKTFDSGDPELIRVYEALAADRLQVIAGDKAEPSLGLDQDTW MSMEG_0402|M.smegmatis_MC2_155 DEDARRRLEATFDT-DPLLRKHFNELATERLQVVAGDKGQPNLGLDEQTW MAV_3243|M.avium_104 DEEAWGRLEKTFNTGDPELLRHFQELAEEHLQVVAGDKGQANLGLDEQTW TH_3730|M.thermoresistible__bu GAVTAR-----------GCLRTVHRLSGDELRSARAELDPAAGTMVRALW Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M DMIQAHHPDGPYNLLGWSMGGVVAHEIAVELRRRGCEVGRLIVLDAAGEV Mb0104|M.bovis_AF2122/97 DEDARRRLEKTFDSGDPELLRHFKELAADRLEVVAGDKSEPDLGLDQPMW Rv0101|M.tuberculosis_H37Rv DEDARRRLEKTFDSGDPELLRHFKELAADRLEVVAGDKSEPDLGLDQPMW MLBr_00484|M.leprae_Br4923 NEDARARLDKTFDSGDPKLLAHYQELATDHLEVIAGDKGEVDLELDRQTW MUL_1722|M.ulcerans_Agy99 DTEARARLEKTFDSGAPELLAHYRALAGDHLEVLAGDKGEADLGLDRQTW Mvan_2578|M.vanbaalenii_PYR-1 DAAARVRLDSTFDSGDPELLRHYRRLAADHLEVIAGDKADADLGLDARTW MAB_4098c|M.abscessus_ATCC_199 QRLADTVDLIVDSAALVNSVLPYSELFGPNVVGTAELIRFALTTKLKPYT MSMEG_0402|M.smegmatis_MC2_155 QRLAESVDLIVDSAAFVNSVLPYSELFGPNVVGTAELIRFALTSKLKPFN MAV_3243|M.avium_104 QQLADTVDLIVDSAAVVNGVLPYSELFTPNVGGTAELIRLALTTRKKPFA TH_3730|M.thermoresistible__bu APDTRRLALIVHHLAVD----------AVSWRILVEDINIAWGQR----- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M DSADS--------------------------------------------- Mb0104|M.bovis_AF2122/97 RRLAETVDLIVDSAAMVN-AFPYHELFGPNVAGTAELIRIALTTKLKPFT Rv0101|M.tuberculosis_H37Rv RRLAETVDLIVDSAAMVN-AFPYHELFGPNVAGTAELIRIALTTKLKPFT MLBr_00484|M.leprae_Br4923 RRLADTVDLIVDPAALVNHVLPYSELFGPNTLGTAELIRIALTSKQKPYI MUL_1722|M.ulcerans_Agy99 QRLADTVDLIVDPAALVNHVLPYSQLFGPNALGTAELLRLALTSKIKPYS Mvan_2578|M.vanbaalenii_PYR-1 QRLADTVDLIVDPAALVNHVLPYRQLFAPNVLGTAELLRIALTTRMKPFV MAB_4098c|M.abscessus_ATCC_199 YISTADVGREIEKSVFREDADIRVISATRPSDGSYANGYGNSKWAGEVLL MSMEG_0402|M.smegmatis_MC2_155 FVSTSDVGRQIEPSRFTEQADIRLVSATRKIEVGYANGYGNSKWAGEVLL MAV_3243|M.avium_104 YVSTSDVGRQIEPSAFTEDADIRVISATRVIDGSYANGYGNSKWAGEVLL TH_3730|M.thermoresistible__bu -----HTGQPIDLP---------------------AGGTSFARWS--TLL Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M -------------------------------------------------- Mb0104|M.bovis_AF2122/97 YVSTADVGAAIEPSAFTEDADIRVISPTRTVDGGWAGGYGTSKWAGEVLL Rv0101|M.tuberculosis_H37Rv YVSTADVGAAIEPSAFTEDADIRVISPTRTVDGGWAGGYGTSKWAGEVLL MLBr_00484|M.leprae_Br4923 YVSTIGVGNQIEPAKFTEDSDIRVISPTRNINNNYANGYGNSKWAGEVLL MUL_1722|M.ulcerans_Agy99 YTSTIGVADQIPPSAFTEDADIRVISATRAVDDSYANGYSNSKWAGEVLL Mvan_2578|M.vanbaalenii_PYR-1 YVSTIGVGAGIEPARFTEDADIRQISATRRIDDSYANGYGNSKWAGEVLL MAB_4098c|M.abscessus_ATCC_199 REAHEQVGLPVKVFRSGMIMVDTSYAGQVNASDTVARMVLSVVATGVAPY MSMEG_0402|M.smegmatis_MC2_155 REAHDHCGLPVAVFRSGMIMVDPTYAGQLNVTDTVSRMVLSIVATGVAPG MAV_3243|M.avium_104 REAHDLCGLPVSVFRSDMILADTSYAGQLNVTDIFTRMILSIVATGTAPK TH_3730|M.thermoresistible__bu AEYADTP----------------EVVAQAGVWQQVAAXXWPSCSTPTTTS Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M ---------------------VAEPASESDVLELILVAAGIDIAEHPRPL Mb0104|M.bovis_AF2122/97 REANDLCALPVAVFRCGMILADTSYAGQLNMSDWVTRMVLSLMATGIAPR Rv0101|M.tuberculosis_H37Rv REANDLCALPVAVFRCGMILADTSYAGQLNMSDWVTRMVLSLMATGIAPR MLBr_00484|M.leprae_Br4923 REAHDLCGLPVTVFRCDMILADTSYAGQLNVPDMFTRMMLSLAATGIAPG MUL_1722|M.ulcerans_Agy99 REAHVLCGLPVAVFRCDMILADTTWAGQLNVPDMFTRMILSLAATGIAPG Mvan_2578|M.vanbaalenii_PYR-1 REAHDLCGLPVSVFRCDMILADTTYAGQLNLPDMFTRLIFSLVATGVAPE MAB_4098c|M.abscessus_ATCC_199 SVYQLDADGNRQRAHFDGLPVEFVAEA----ITALGGGAAGSFDGS--AD MSMEG_0402|M.smegmatis_MC2_155 SFYQRGDNGERQRAHFDGLPVDFVAQA----ITKLGWQVARSVTDSTASG MAV_3243|M.avium_104 SFYRLDADGNRQRSHFDALPVEFVAEA----IAKLGAQVMD--------G TH_3730|M.thermoresistible__bu -----SSTSTWRSTRSTGRPVRTGCST----RCSS--------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M TYHEAEALLNQRTPVEFSLPPRRIVEIMLDN------------------- Mb0104|M.bovis_AF2122/97 SFYEPDSEGNRQRAHFDGLPVTFVAEAIAVLGARVAG--------SSLAG Rv0101|M.tuberculosis_H37Rv SFYEPDSEGNRQRAHFDGLPVTFVAEAIAVLGARVAG--------SSLAG MLBr_00484|M.leprae_Br4923 SFYELDAESNRQRAHYDGLPVEFIAEAISTLGDQSL---------HDRDG MUL_1722|M.ulcerans_Agy99 SFYELAADGARQRAHYDGLPVEFIAEAISTLGAQ------------SQDG Mvan_2578|M.vanbaalenii_PYR-1 SFYHLATDGTRQRAHYDGLPVEFIAEAISTLGSD------------VASG MAB_4098c|M.abscessus_ATCC_199 FETYHVMNPHDDGIGIDEYVDWLIEAGHPIERIDDFGEWVRQFEARLHAL MSMEG_0402|M.smegmatis_MC2_155 FETYHVMNPHDDGIGIDTYIDWLIEAGYPIERIEDFGEWLQRFEAALQGL MAV_3243|M.avium_104 FETYHVMNPHDDGIGLDEYVDWLIEAGYPIERVDDFGEWLQRFETGLRGL TH_3730|M.thermoresistible__bu -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M -------------------------------------------------- Mb0104|M.bovis_AF2122/97 FATYHVMNPHDDGIGLDEYVDWLIEAGYPIRRIDDFAEWLQRFEASLGAL Rv0101|M.tuberculosis_H37Rv FATYHVMNPHDDGIGLDEYVDWLIEAGYPIRRIDDFAEWLQRFEASLGAL MLBr_00484|M.leprae_Br4923 FTTYHVMNPHDDGIGMDEFVDWLIDAGCPIQRINDYDEWLRRFEISLRAL MUL_1722|M.ulcerans_Agy99 FHTYHVMNPYDDGIGLDEFVDWLNESGCPIQRIADYGDWLQRFETALRAL Mvan_2578|M.vanbaalenii_PYR-1 FRTYHVMNPHDDGIGLDEYVDWLIDAGHPIRRVGDYPTWLQRFTVAITAL MAB_4098c|M.abscessus_ATCC_199 PDHQRQGSVLQMLKILQDHGWDGQPPEPVRGPMAPADRFHAAVRKAKIGS MSMEG_0402|M.smegmatis_MC2_155 SDQQRQNSVLQMLTLLKQQAGELQPPVPTRGSFAPADRFQAAVRDANIGV MAV_3243|M.avium_104 PERQRQNSVLQMLLLLLRDPKNLQLAEPARGAFAPTDRFRAAVQEAKVGS TH_3730|M.thermoresistible__bu -----TRTIRSMRRRWPGRKALRSPISRAANTTTIRCRWSQCPGTSSDCA Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M -MNANQSMRLKHVPDVFDGDMIVFSAKRDSGGRSLADSWRQYVAGDITEY Mb0104|M.bovis_AF2122/97 PDRQRRHSVLPMLLASNSQR--LQPLKPTRGCSAPTDRFRAAVRAAKVGS Rv0101|M.tuberculosis_H37Rv PDRQRRHSVLPMLLASNSQR--LQPLKPTRGCSAPTDRFRAAVRAAKVGS MLBr_00484|M.leprae_Br4923 PERQRHSSLLPLLHNYQ------KPEKPLHGSLAPTIRFRTAVQNANIGQ MUL_1722|M.ulcerans_Agy99 PDRQRHSSLLPLLHNYR------QPERPVRGSIAPTDRFRAAVQEAKIGP Mvan_2578|M.vanbaalenii_PYR-1 PERQRQASLLPLLHNYQ------HPETPIRGSIAPTDRFREAVQDAKIGP MAB_4098c|M.abscessus_ATCC_199 DHD---IPQVSAPIIAKYASDLQLHGLL-- MSMEG_0402|M.smegmatis_MC2_155 EGE---IPHVTREVIVKYVTDLQLLGLL-- MAV_3243|M.avium_104 DND---IPHISAPVIVKYVTDLQLLGLL-- TH_3730|M.thermoresistible__bu SNT---TPRCSTPRMSRHWSAGCGGC---- Mflv_2697|M.gilvum_PYR-GCK ------------------------------ MMAR_0099|M.marinum_M PID---CTHEAMLNIESLQLFADRIAIYLR Mb0104|M.bovis_AF2122/97 DKDNPDIPHVSAPTIINYVTNLQLLGLL-- Rv0101|M.tuberculosis_H37Rv DKDNPDIPHVSAPTIINYVTNLQLLGLL-- MLBr_00484|M.leprae_Br4923 DKD---IPHISPAIIAKYVSDLQLLGLV-- MUL_1722|M.ulcerans_Agy99 DKD---IPHVGAPIIVKYVSDLRLLGLL-- Mvan_2578|M.vanbaalenii_PYR-1 DKD---IPHVTPQIVIKYVTDLQRLGLL--