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TPLQRYIAEEIATDHLDGLMSRREALRRLGLLGLSTAAATAVIAACSEREQTTTATTENTTDTAGPPTTE TQPPSAEPPGMQTALPTAAVTWAGPTGELQGAWAEAPDARGAVLVIHENKGLTDHIRSVAGRFAGIGYSA LAIDLLSGQGGTGQFADPADATAALSKIPPEEFVANLRSGIDELSRRAPDRKLAAVGFCMGGGLVWRLLA AGTPQLAAAVPFYGPTPDDPDFAGSKDVAVLAFYGALDQRVNATEPVARAALEKAGLVHELVTEPGANHA FFNDTGDRYDPTAAADAWRRIQEWFTAHLA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3558 | - | - | 100% (311) | carboxymethylenebutenolidase |
| M. smegmatis MC2 155 | MSMEG_2444 | - | 6e-10 | 26.67% (240) | dienelactone hydrolase family protein |
| M. smegmatis MC2 155 | MSMEG_2669 | - | 2e-08 | 26.53% (245) | hydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2080 | - | 2e-09 | 26.16% (237) | hypothetical protein Mb2080 |
| M. gilvum PYR-GCK | Mflv_3311 | - | 1e-130 | 73.55% (310) | dienelactone hydrolase |
| M. tuberculosis H37Rv | Rv2054 | - | 2e-09 | 26.16% (237) | hypothetical protein Rv2054 |
| M. leprae Br4923 | MLBr_01444 | - | 6e-08 | 24.09% (220) | putative dienelactone hydrolase |
| M. abscessus ATCC 19977 | MAB_3265c | - | 1e-102 | 58.39% (310) | hypothetical protein MAB_3265c |
| M. marinum M | MMAR_1955 | - | 2e-09 | 25.93% (243) | alanine rich hydrolase |
| M. avium 104 | MAV_0487 | - | 3e-20 | 33.96% (212) | dienelactone hydrolase family protein |
| M. thermoresistible (build 8) | TH_0693 | - | 4e-08 | 25.33% (225) | PROBABLE ALANINE RICH HYDROLASE |
| M. ulcerans Agy99 | MUL_2177 | - | 9e-10 | 25.93% (243) | alanine rich hydrolase |
| M. vanbaalenii PYR-1 | Mvan_3034 | - | 1e-126 | 70.22% (319) | dienelactone hydrolase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2080|M.bovis_AF2122/97 --------MTTIEID-----------------------------------
Rv2054|M.tuberculosis_H37Rv --------MTTIEID-----------------------------------
MLBr_01444|M.leprae_Br4923 --------MTKIQID-----------------------------------
MAV_0487|M.avium_104 --------MTDIDLTDLA--------------------------------
Mflv_3311|M.gilvum_PYR-GCK MTPLQRYIAEEIATDHVDGLMSRREALRRLALLGVGGAAATALIAACGQN
Mvan_3034|M.vanbaalenii_PYR-1 ---MQRYIAEEIATDHVDGLLTRREAMRRLALLGVGGAAATALIAACGQN
MSMEG_3558|M.smegmatis_MC2_155 MTPLQRYIAEEIATDHLDGLMSRREALRRLGLLGLSTAAATAVIAACSER
MAB_3265c|M.abscessus_ATCC_199 MTPLQRYIAEEIATDHIEGLLTRREAFRRLALLGVGATAAGALISACGTG
MMAR_1955|M.marinum_M --------MPIISDS-----------------------------------
MUL_2177|M.ulcerans_Agy99 --------MPIISDS-----------------------------------
TH_0693|M.thermoresistible__bu --------------------------------------------------
Mb2080|M.bovis_AF2122/97 ----------------------APAG--PIDALLGLPPGQGPWPG-----
Rv2054|M.tuberculosis_H37Rv ----------------------APAG--PIDALLGLPPGQGPWPG-----
MLBr_01444|M.leprae_Br4923 ----------------------APDG--PIDALLSVPPGPEPWPG-----
MAV_0487|M.avium_104 ---------------------AAHAGSQPLRGYLATPSGTGPWPG-----
Mflv_3311|M.gilvum_PYR-GCK QQ--SAETT--AEP--SPTSDTPTSDAPPPGMDAALPTEPVTWAGPKGEL
Mvan_3034|M.vanbaalenii_PYR-1 RQPETAGTS--PEAPGSPASSTADRAAPPPGMDRALPTTPVTWAGPAGEL
MSMEG_3558|M.smegmatis_MC2_155 EQTTTATTENTTDTAGPPTTETQPPSAEPPGMQTALPTAAVTWAGPTGEL
MAB_3265c|M.abscessus_ATCC_199 NKPVAAPAP-------------ANSGAPPPGMDNVVVTEPITWRGPNGTL
MMAR_1955|M.marinum_M ----------------------VSTPDGTCPVRLFTPAGPGPWPG-----
MUL_2177|M.ulcerans_Agy99 ----------------------VSTPDGTCPVRLFTPAGPGPWPG-----
TH_0693|M.thermoresistible__bu -------------------------------VTLHTPDGAGPWPG-----
.* *
Mb2080|M.bovis_AF2122/97 -------------------------VVVVHDAVGYVPDNKLISERIARAG
Rv2054|M.tuberculosis_H37Rv -------------------------VVVVHDAVGYVPDNKLISERIARAG
MLBr_01444|M.leprae_Br4923 -------------------------VVVIHDAIGYEPDKESTNNHIAMAG
MAV_0487|M.avium_104 -------------------------VVLIHEVFGIDDVMRRHTDRLAGLG
Mflv_3311|M.gilvum_PYR-GCK QGAWAQA------------AEPRGGILVIHENKGLNDWTRSVAGRLAGAG
Mvan_3034|M.vanbaalenii_PYR-1 QGAWAPAGASEATGNEGTSGDARGGILVIHENKGLNDWVRSVAGRLAGAG
MSMEG_3558|M.smegmatis_MC2_155 QGAWAEA------------PDARGAVLVIHENKGLTDHIRSVAGRFAGIG
MAB_3265c|M.abscessus_ATCC_199 QGAWATA------------AEPRGTVLVIHENKGLNDWVRSVAGRLAGVG
MMAR_1955|M.marinum_M -------------------------VIMFPDAGGVRETFEQMAATLAGHG
MUL_2177|M.ulcerans_Agy99 -------------------------VIMFPDAGGVRETFEQMAATLAGHG
TH_0693|M.thermoresistible__bu -------------------------VVLFVDAGGTRDLMREMADRLAGYG
:::. : * . :* *
Mb2080|M.bovis_AF2122/97 YVVLTPNMYARGG---------RARCITRVFRELLTKRGRALDDILAARD
Rv2054|M.tuberculosis_H37Rv YVVLTPNMYARGG---------RARCITRVFRELLTKRGRALDDILAARD
MLBr_01444|M.leprae_Br4923 YVAITPNLYSRGS---------RARCITRVMRELLTKRGRAFDDILATRD
MAV_0487|M.avium_104 YLTLAVDLFSAGG---------AARCLISTMTAMIRGRGRAFADIAAARD
Mflv_3311|M.gilvum_PYR-GCK YSSLAIDLLSERG---------GTATFADPAEATAALGARTPEDMVADLR
Mvan_3034|M.vanbaalenii_PYR-1 YSSLAIDLLSGQG---------GTATFADPAEATAALGQRTPEDMVADLK
MSMEG_3558|M.smegmatis_MC2_155 YSALAIDLLSGQG---------GTGQFADPADATAALSKIPPEEFVANLR
MAB_3265c|M.abscessus_ATCC_199 YSSLAIDLLSEEG---------GASAFKDPAEATGTLGRIAPERFIADLK
MMAR_1955|M.marinum_M YVVLLPDVYYREGDWTPFAMETVFGDADERARLMFMLGTLTPDRVTRDAG
MUL_2177|M.ulcerans_Agy99 YVVLLPDVYYREGDWTPFAMETVFGDADERARLMFMLGTLTPDRVTRDAG
TH_0693|M.thermoresistible__bu YAVLVPDVYYRHGRWEPFDMRTVFGDPSERARLYRMIRSITPDMMETDAR
* : :: . . .
Mb2080|M.bovis_AF2122/97 HLLAMPECSG-----RVGIVGFCMGGQFALVLSPRG---FGATAPFYGT-
Rv2054|M.tuberculosis_H37Rv HLLAMPECSG-----RVGIVGFCMGGQFALVLSPRG---FGATAPFYGT-
MLBr_01444|M.leprae_Br4923 YLLAMPKCSG-----RVGIAGFCMGGRFALVMSPKG---FDASAPFYGT-
MAV_0487|M.avium_104 YLAGSADCTG-----KVGVIGFCMGGGFALLTANTG---YDAAAVNYG--
Mflv_3311|M.gilvum_PYR-GCK SGIAEVQRRTPDK--KVAAIGFCMGGGLVWRLLAAGTPELAAAFPFYG--
Mvan_3034|M.vanbaalenii_PYR-1 SGIAEVARRTPGK--KVAAIGFCMGGGLVWRLLAAGSPELAAAFPFYG--
MSMEG_3558|M.smegmatis_MC2_155 SGIDELSRRAPDR--KLAAVGFCMGGGLVWRLLAAGTPQLAAAVPFYG--
MAB_3265c|M.abscessus_ATCC_199 SGVDEILRRVPGK--PAGAVGFCFGGGLVWQLLAAGEPRLAAAAPFYG--
MMAR_1955|M.marinum_M AYFDYLATRPQVSGERFGVCGYCMGGRISVLLAGRQPDRVAAAASFHGGG
MUL_2177|M.ulcerans_Agy99 AYFDYLATRPQVSGERFGVCGYCMGGRISVLLAGRQPDRVAAAASFHGGD
TH_0693|M.thermoresistible__bu AFFDFLQSRPEVKGDRFGVFGYCMGGRMSVTVAGRVPDRVAAAASFHAAG
. *:*:** : *: :.
Mb2080|M.bovis_AF2122/97 ---PLPRHLSETLNGACPIVASFGTRDPL--GIGAANRLRKVTAAKNIPA
Rv2054|M.tuberculosis_H37Rv ---PLPRHLSETLNGACPIVASFGTRDPL--GIGAANRLRKVTAAKNIPA
MLBr_01444|M.leprae_Br4923 ---PLPRNLSETLNGACPIVASFGGRDPL--GIGAPKRLRQATQTRHITT
MAV_0487|M.avium_104 ---QLPRHLDTALAGACPIVGSYGGRDPS--LRGATRKLNEALTKAGIEH
Mflv_3311|M.gilvum_PYR-GCK ---PTPEAPDFAGSRDVAVLAFYGELDQR--VNATEPDARAALEKAGLVH
Mvan_3034|M.vanbaalenii_PYR-1 ---PTPDNPDFAASKDVAVLGFYGELDQR--VNATEPVAAAALQKAGLVH
MSMEG_3558|M.smegmatis_MC2_155 ---PTPDDPDFAGSKDVAVLAFYGALDQR--VNATEPVARAALEKAGLVH
MAB_3265c|M.abscessus_ATCC_199 ---PLPDNPDFSRSK-AAVLAFYGELDER--VTASKDQAADALRRGGLLH
MMAR_1955|M.marinum_M LVTDNPDSPHLLADRMTARLYVGGAQNDPSFTTDHAEQLEKALTAAGVEH
MUL_2177|M.ulcerans_Agy99 LVTDNPDSPHLLADRMTARLYVGGATNDPSFTTDHAEQLEKALTAAGVEH
TH_0693|M.thermoresistible__bu LVTDDPTSPHLLAERIKATVYVAGAQDDDGFTPAHAETLGKALTDAGVEH
* . : * : . :
Mb2080|M.bovis_AF2122/97 DIKSYPGAGHSFANKLPG-----QPLVRIAGFGYNEAATEDAWRRVFEFF
Rv2054|M.tuberculosis_H37Rv DIKSYPGAGHSFANKLPG-----QPLVRIAGFGYNEAATEDAWRRVFEFF
MLBr_01444|M.leprae_Br4923 DIKVYPDAGHSFANKLPG-----QPLMRITGFGYNQAATEDAWSRVFAFF
MAV_0487|M.avium_104 DVKEYPAASHAFLNDDEAGPRILRPLLRVAGIGPEPDSAQDAWNRIAAFF
Mflv_3311|M.gilvum_PYR-GCK EIVIEPGANHAFFNDTGD--------------RYDPAAAADAWERTLAWL
Mvan_3034|M.vanbaalenii_PYR-1 ELVTEPGANHAFFNDTGD--------------RYDPAAAADAWSRTLDWL
MSMEG_3558|M.smegmatis_MC2_155 ELVTEPGANHAFFNDTGD--------------RYDPTAAADAWRRIQEWF
MAB_3265c|M.abscessus_ATCC_199 EIAVEPGADHAFFNDSGP--------------RYNASAAVDAWQRLLGWL
MMAR_1955|M.marinum_M TIEWYPGAHGFAVPDNPP---------------YDEACAQRHWTAMTDLF
MUL_2177|M.ulcerans_Agy99 TIEWYPGAHGFAVPDNPP---------------YDEACAQRHWTAMTDLF
TH_0693|M.thermoresistible__bu TIEFYPAGHGFAVPDNLP---------------YDEQAAERHWDALRALF
: * . . : .: * :
Mb2080|M.bovis_AF2122/97 GQHLRAGSPGEP
Rv2054|M.tuberculosis_H37Rv GQHLRAGSPGEP
MLBr_01444|M.leprae_Br4923 DKHLRTD-----
MAV_0487|M.avium_104 ATHLH-------
Mflv_3311|M.gilvum_PYR-GCK TAHVG-------
Mvan_3034|M.vanbaalenii_PYR-1 AAHVG-------
MSMEG_3558|M.smegmatis_MC2_155 TAHLA-------
MAB_3265c|M.abscessus_ATCC_199 GQHIG-------
MMAR_1955|M.marinum_M AATLSR------
MUL_2177|M.ulcerans_Agy99 AATLSR------
TH_0693|M.thermoresistible__bu DRELSG------
: