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TDIDLTDLAAAHAGSQPLRGYLATPSGTGPWPGVVLIHEVFGIDDVMRRHTDRLAGLGYLTLAVDLFSAG GAARCLISTMTAMIRGRGRAFADIAAARDYLAGSADCTGKVGVIGFCMGGGFALLTANTGYDAAAVNYGQ LPRHLDTALAGACPIVGSYGGRDPSLRGATRKLNEALTKAGIEHDVKEYPAASHAFLNDDEAGPRILRPL LRVAGIGPEPDSAQDAWNRIAAFFATHLH*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_0487 | - | - | 100% (240) | dienelactone hydrolase family protein |
| M. avium 104 | MAV_2443 | - | 5e-46 | 44.12% (204) | dienelactone hydrolase family protein |
| M. avium 104 | MAV_3654 | - | 3e-18 | 33.33% (222) | hydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2080 | - | 2e-50 | 42.29% (227) | hypothetical protein Mb2080 |
| M. gilvum PYR-GCK | Mflv_3311 | - | 2e-21 | 34.10% (217) | dienelactone hydrolase |
| M. tuberculosis H37Rv | Rv2054 | - | 2e-50 | 42.29% (227) | hypothetical protein Rv2054 |
| M. leprae Br4923 | MLBr_01444 | - | 3e-51 | 43.95% (223) | putative dienelactone hydrolase |
| M. abscessus ATCC 19977 | MAB_3265c | - | 2e-19 | 32.59% (224) | hypothetical protein MAB_3265c |
| M. marinum M | MMAR_3032 | - | 4e-52 | 45.29% (223) | hypothetical protein MMAR_3032 |
| M. smegmatis MC2 155 | MSMEG_2444 | - | 2e-51 | 45.74% (223) | dienelactone hydrolase family protein |
| M. thermoresistible (build 8) | TH_0693 | - | 7e-17 | 31.73% (208) | PROBABLE ALANINE RICH HYDROLASE |
| M. ulcerans Agy99 | MUL_2272 | - | 7e-52 | 44.84% (223) | hypothetical protein MUL_2272 |
| M. vanbaalenii PYR-1 | Mvan_3034 | - | 1e-21 | 34.11% (214) | dienelactone hydrolase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2080|M.bovis_AF2122/97 --------------------------MTTIEID-----------------
Rv2054|M.tuberculosis_H37Rv --------------------------MTTIEID-----------------
MMAR_3032|M.marinum_M --MTPTYGNCARVPRTVATRLQLDDAMTTIDID-----------------
MUL_2272|M.ulcerans_Agy99 --------------------------MTTIDID-----------------
MLBr_01444|M.leprae_Br4923 --------------------------MTKIQID-----------------
MSMEG_2444|M.smegmatis_MC2_155 ---------------------------MTITIS-----------------
MAV_0487|M.avium_104 --------------------------MTDIDLTDL---------------
Mflv_3311|M.gilvum_PYR-GCK MTPLQRYIAEEIATDHVDGLMSRREALRRLALLGVGGAAATALIAACGQN
Mvan_3034|M.vanbaalenii_PYR-1 ---MQRYIAEEIATDHVDGLLTRREAMRRLALLGVGGAAATALIAACGQN
MAB_3265c|M.abscessus_ATCC_199 MTPLQRYIAEEIATDHIEGLLTRREAFRRLALLGVGATAAGALISACG--
TH_0693|M.thermoresistible__bu --------------------------------------------------
Mb2080|M.bovis_AF2122/97 --------------------APAG--PIDALLGLPPGQGPWPG-------
Rv2054|M.tuberculosis_H37Rv --------------------APAG--PIDALLGLPPGQGPWPG-------
MMAR_3032|M.marinum_M --------------------TPAG--PIDALLGVPTGEGPWPG-------
MUL_2272|M.ulcerans_Agy99 --------------------TPAG--PIDALLGVPTGEGPWPG-------
MLBr_01444|M.leprae_Br4923 --------------------APDG--PIDALLSVPPGPEPWPG-------
MSMEG_2444|M.smegmatis_MC2_155 --------------------TPDG--PIDALLSTPTGSGPWPG-------
MAV_0487|M.avium_104 ------------------AAAHAGSQPLRGYLATPSGTGPWPG-------
Mflv_3311|M.gilvum_PYR-GCK QQ--SAETTAEP--SPTSDTPTSDAPPPGMDAALPTEPVTWAGPKGELQG
Mvan_3034|M.vanbaalenii_PYR-1 RQPETAGTSPEAPGSPASSTADRAAPPPGMDRALPTTPVTWAGPAGELQG
MAB_3265c|M.abscessus_ATCC_199 -------TGNKP--VAAPAPANSGAPPPGMDNVVVTEPITWRGPNGTLQG
TH_0693|M.thermoresistible__bu -----------------------------VTLHTPDGAGPWPG-------
.* *
Mb2080|M.bovis_AF2122/97 -----------------------VVVVHDAVGYVPDNKLISERIARAGYV
Rv2054|M.tuberculosis_H37Rv -----------------------VVVVHDAVGYVPDNKLISERIARAGYV
MMAR_3032|M.marinum_M -----------------------VVVVHDAIGYAPDNEAISERIAAAGYL
MUL_2272|M.ulcerans_Agy99 -----------------------VVVVHDAIGYAPDNEAISERIAAAGYL
MLBr_01444|M.leprae_Br4923 -----------------------VVVIHDAIGYEPDKESTNNHIAMAGYV
MSMEG_2444|M.smegmatis_MC2_155 -----------------------VVIIHDAIGYGPDNELVSERVAQAGYL
MAV_0487|M.avium_104 -----------------------VVLIHEVFGIDDVMRRHTDRLAGLGYL
Mflv_3311|M.gilvum_PYR-GCK AWAQA------------AEPRGGILVIHENKGLNDWTRSVAGRLAGAGYS
Mvan_3034|M.vanbaalenii_PYR-1 AWAPAGASEATGNEGTSGDARGGILVIHENKGLNDWVRSVAGRLAGAGYS
MAB_3265c|M.abscessus_ATCC_199 AWATA------------AEPRGTVLVIHENKGLNDWVRSVAGRLAGVGYS
TH_0693|M.thermoresistible__bu -----------------------VVLFVDAGGTRDLMREMADRLAGYGYA
:::. : * . ::* **
Mb2080|M.bovis_AF2122/97 VLTPNMYARGGRARCITR---------VFRELLTKRGRALDDILAARDHL
Rv2054|M.tuberculosis_H37Rv VLTPNMYARGGRARCITR---------VFRELLTKRGRALDDILAARDHL
MMAR_3032|M.marinum_M ALTPNMYARGGRARCITR---------VFRELLTKRGRALDDILAARDHL
MUL_2272|M.ulcerans_Agy99 ALTPNMYARGGRARCITR---------VFRELLTKRGRALDDILAARDHL
MLBr_01444|M.leprae_Br4923 AITPNLYSRGSRARCITR---------VMRELLTKRGRAFDDILATRDYL
MSMEG_2444|M.smegmatis_MC2_155 AITPNLYSRGGRARCITR---------MFRDLLTQRGRALDDILAARDHL
MAV_0487|M.avium_104 TLAVDLFSAGGAARCLIS---------TMTAMIRGRGRAFADIAAARDYL
Mflv_3311|M.gilvum_PYR-GCK SLAIDLLSERGGTATFAD---------PAEATAALGARTPEDMVADLRSG
Mvan_3034|M.vanbaalenii_PYR-1 SLAIDLLSGQGGTATFAD---------PAEATAALGQRTPEDMVADLKSG
MAB_3265c|M.abscessus_ATCC_199 SLAIDLLSEEGGASAFKD---------PAEATGTLGRIAPERFIADLKSG
TH_0693|M.thermoresistible__bu VLVPDVYYRHGRWEPFDMRTVFGDPSERARLYRMIRSITPDMMETDARAF
:. :: . : : : :
Mb2080|M.bovis_AF2122/97 LAMPECSG-----RVGIVGFCMGGQFALVLSPRG---FGATAPFYGT---
Rv2054|M.tuberculosis_H37Rv LAMPECSG-----RVGIVGFCMGGQFALVLSPRG---FGATAPFYGT---
MMAR_3032|M.marinum_M LAMAECSG-----QVGIAGFCMGGQFALILSPRG---FGASAPFYGT---
MUL_2272|M.ulcerans_Agy99 LAMAECSG-----QVGIAGFCMGGQFALILSPRG---FGASAPFYGT---
MLBr_01444|M.leprae_Br4923 LAMPKCSG-----RVGIAGFCMGGRFALVMSPKG---FDASAPFYGT---
MSMEG_2444|M.smegmatis_MC2_155 KSLPECTG-----TVGVVGFCSGGQFALIMGPKG---FAASAPFYGT---
MAV_0487|M.avium_104 AGSADCTG-----KVGVIGFCMGGGFALLTANTG---YDAAAVNYG----
Mflv_3311|M.gilvum_PYR-GCK IAEVQRRTPDK--KVAAIGFCMGGGLVWRLLAAGTPELAAAFPFYG----
Mvan_3034|M.vanbaalenii_PYR-1 IAEVARRTPGK--KVAAIGFCMGGGLVWRLLAAGSPELAAAFPFYG----
MAB_3265c|M.abscessus_ATCC_199 VDEILRRVPGK--PAGAVGFCFGGGLVWQLLAAGEPRLAAAAPFYG----
TH_0693|M.thermoresistible__bu FDFLQSRPEVKGDRFGVFGYCMGGRMSVTVAGRVPDRVAAAASFHAAGLV
. *:* ** : *: :.
Mb2080|M.bovis_AF2122/97 ---PLPRHLSETLNGACPIVASFGTRDPLGIGAANRLRKVTAAKNIPADI
Rv2054|M.tuberculosis_H37Rv ---PLPRHLSETLNGACPIVASFGTRDPLGIGAANRLRKVTAAKNIPADI
MMAR_3032|M.marinum_M ---PLPRHLSETLDGACPIVASFGNRDPLGLGAPSRLREVTQAKQIPADI
MUL_2272|M.ulcerans_Agy99 ---PLPRHLSETLDGACPIVASFGNRDPLGLGAPSRLREVTQAKQIPADI
MLBr_01444|M.leprae_Br4923 ---PLPRNLSETLNGACPIVASFGGRDPLGIGAPKRLRQATQTRHITTDI
MSMEG_2444|M.smegmatis_MC2_155 ---PLPRHLDRTLDASCPIVASFGRRDPLGIGAPARLRRVVEAKNIPADI
MAV_0487|M.avium_104 ---QLPRHLDTALAGACPIVGSYGGRDPSLRGATRKLNEALTKAGIEHDV
Mflv_3311|M.gilvum_PYR-GCK ---PTPEAPDFAGSRDVAVLAFYGELDQRVNATEPDARAALEKAGLVHEI
Mvan_3034|M.vanbaalenii_PYR-1 ---PTPDNPDFAASKDVAVLGFYGELDQRVNATEPVAAAALQKAGLVHEL
MAB_3265c|M.abscessus_ATCC_199 ---PLPDNPDFSRSK-AAVLAFYGELDERVTASKDQAADALRRGGLLHEI
TH_0693|M.thermoresistible__bu TDDPTSPHLLAERIKATVYVAGAQDDDGFTPAHAETLGKALTDAGVEHTI
. :. * . . : :
Mb2080|M.bovis_AF2122/97 KSYPGAGHSFANKLPG-----QPLVRIAGFGYNEAATEDAWRRVFEFFGQ
Rv2054|M.tuberculosis_H37Rv KSYPGAGHSFANKLPG-----QPLVRIAGFGYNEAATEDAWRRVFEFFGQ
MMAR_3032|M.marinum_M KGYPGAGHSFANKLPR-----QPLLRITGFGYNEAATEDAWGRVFAFFGE
MUL_2272|M.ulcerans_Agy99 EGYPGAGHSFANKLPR-----QPLLRITGFGYNEAATEDAWGRVFAFFGE
MLBr_01444|M.leprae_Br4923 KVYPDAGHSFANKLPG-----QPLMRITGFGYNQAATEDAWSRVFAFFDK
MSMEG_2444|M.smegmatis_MC2_155 KVYPSAGHSFANILPA-----QPLLRVTGFGYDEAATTDAWTRVFAFFDE
MAV_0487|M.avium_104 KEYPAASHAFLNDDEAGPRILRPLLRVAGIGPEPDSAQDAWNRIAAFFAT
Mflv_3311|M.gilvum_PYR-GCK VIEPGANHAFFNDTGD--------------RYDPAAAADAWERTLAWLTA
Mvan_3034|M.vanbaalenii_PYR-1 VTEPGANHAFFNDTGD--------------RYDPAAAADAWSRTLDWLAA
MAB_3265c|M.abscessus_ATCC_199 AVEPGADHAFFNDSGP--------------RYNASAAVDAWQRLLGWLGQ
TH_0693|M.thermoresistible__bu EFYP-AGHGFAVPDNLP--------------YDEQAAERHWDALRALFDR
* *.*.* : :: * :
Mb2080|M.bovis_AF2122/97 HLRAGSPGEP
Rv2054|M.tuberculosis_H37Rv HLRAGSPGEP
MMAR_3032|M.marinum_M HLAAGTSRG-
MUL_2272|M.ulcerans_Agy99 HLAAGTSGN-
MLBr_01444|M.leprae_Br4923 HLRTD-----
MSMEG_2444|M.smegmatis_MC2_155 HLKPKTAGQA
MAV_0487|M.avium_104 HLH-------
Mflv_3311|M.gilvum_PYR-GCK HVG-------
Mvan_3034|M.vanbaalenii_PYR-1 HVG-------
MAB_3265c|M.abscessus_ATCC_199 HIG-------
TH_0693|M.thermoresistible__bu ELSG------
.: