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TPLQRYIAEEIATDHVDGLMSRREALRRLALLGVGGAAATALIAACGQNQQSAETTAEPSPTSDTPTSDA PPPGMDAALPTEPVTWAGPKGELQGAWAQAAEPRGGILVIHENKGLNDWTRSVAGRLAGAGYSSLAIDLL SERGGTATFADPAEATAALGARTPEDMVADLRSGIAEVQRRTPDKKVAAIGFCMGGGLVWRLLAAGTPEL AAAFPFYGPTPEAPDFAGSRDVAVLAFYGELDQRVNATEPDARAALEKAGLVHEIVIEPGANHAFFNDTG DRYDPAAAADAWERTLAWLTAHVG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3311 | - | - | 100% (305) | dienelactone hydrolase |
| M. gilvum PYR-GCK | Mflv_4008 | - | 7e-09 | 26.67% (240) | dienelactone hydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2080 | - | 5e-10 | 25.51% (247) | hypothetical protein Mb2080 |
| M. tuberculosis H37Rv | Rv2054 | - | 5e-10 | 25.51% (247) | hypothetical protein Rv2054 |
| M. leprae Br4923 | MLBr_01444 | - | 2e-11 | 26.12% (245) | putative dienelactone hydrolase |
| M. abscessus ATCC 19977 | MAB_3265c | - | 1e-115 | 65.57% (305) | hypothetical protein MAB_3265c |
| M. marinum M | MMAR_3032 | - | 1e-11 | 27.57% (243) | hypothetical protein MMAR_3032 |
| M. avium 104 | MAV_0487 | - | 3e-21 | 34.10% (217) | dienelactone hydrolase family protein |
| M. smegmatis MC2 155 | MSMEG_3558 | - | 1e-130 | 73.55% (310) | carboxymethylenebutenolidase |
| M. thermoresistible (build 8) | TH_0693 | - | 7e-10 | 27.96% (211) | PROBABLE ALANINE RICH HYDROLASE |
| M. ulcerans Agy99 | MUL_2272 | - | 2e-11 | 27.59% (232) | hypothetical protein MUL_2272 |
| M. vanbaalenii PYR-1 | Mvan_3034 | - | 1e-144 | 80.82% (318) | dienelactone hydrolase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3032|M.marinum_M --MTPTYGNCARVPRTVATRLQLDDAMTTIDID-----------------
MUL_2272|M.ulcerans_Agy99 --------------------------MTTIDID-----------------
Mb2080|M.bovis_AF2122/97 --------------------------MTTIEID-----------------
Rv2054|M.tuberculosis_H37Rv --------------------------MTTIEID-----------------
MLBr_01444|M.leprae_Br4923 --------------------------MTKIQID-----------------
MAV_0487|M.avium_104 --------------------------MTDIDLTDL---------------
Mflv_3311|M.gilvum_PYR-GCK MTPLQRYIAEEIATDHVDGLMSRREALRRLALLGVGGAAATALIAACGQN
Mvan_3034|M.vanbaalenii_PYR-1 ---MQRYIAEEIATDHVDGLLTRREAMRRLALLGVGGAAATALIAACGQN
MSMEG_3558|M.smegmatis_MC2_155 MTPLQRYIAEEIATDHLDGLMSRREALRRLGLLGLSTAAATAVIAACSER
MAB_3265c|M.abscessus_ATCC_199 MTPLQRYIAEEIATDHIEGLLTRREAFRRLALLGVGATAAGALISACGTG
TH_0693|M.thermoresistible__bu --------------------------------------------------
MMAR_3032|M.marinum_M ----------------------TPAG--PIDALLGVPTGEGPWPG-----
MUL_2272|M.ulcerans_Agy99 ----------------------TPAG--PIDALLGVPTGEGPWPG-----
Mb2080|M.bovis_AF2122/97 ----------------------APAG--PIDALLGLPPGQGPWPG-----
Rv2054|M.tuberculosis_H37Rv ----------------------APAG--PIDALLGLPPGQGPWPG-----
MLBr_01444|M.leprae_Br4923 ----------------------APDG--PIDALLSVPPGPEPWPG-----
MAV_0487|M.avium_104 --------------------AAAHAGSQPLRGYLATPSGTGPWPG-----
Mflv_3311|M.gilvum_PYR-GCK QQ--SAETT--AEP--SPTSDTPTSDAPPPGMDAALPTEPVTWAGPKGEL
Mvan_3034|M.vanbaalenii_PYR-1 RQPETAGTS--PEAPGSPASSTADRAAPPPGMDRALPTTPVTWAGPAGEL
MSMEG_3558|M.smegmatis_MC2_155 EQTTTATTENTTDTAGPPTTETQPPSAEPPGMQTALPTAAVTWAGPTGEL
MAB_3265c|M.abscessus_ATCC_199 NKPVAAPAP-------------ANSGAPPPGMDNVVVTEPITWRGPNGTL
TH_0693|M.thermoresistible__bu -------------------------------VTLHTPDGAGPWPG-----
.* *
MMAR_3032|M.marinum_M -------------------------VVVVHDAIGYAPDNEAISERIAAAG
MUL_2272|M.ulcerans_Agy99 -------------------------VVVVHDAIGYAPDNEAISERIAAAG
Mb2080|M.bovis_AF2122/97 -------------------------VVVVHDAVGYVPDNKLISERIARAG
Rv2054|M.tuberculosis_H37Rv -------------------------VVVVHDAVGYVPDNKLISERIARAG
MLBr_01444|M.leprae_Br4923 -------------------------VVVIHDAIGYEPDKESTNNHIAMAG
MAV_0487|M.avium_104 -------------------------VVLIHEVFGIDDVMRRHTDRLAGLG
Mflv_3311|M.gilvum_PYR-GCK QGAWAQA------------AEPRGGILVIHENKGLNDWTRSVAGRLAGAG
Mvan_3034|M.vanbaalenii_PYR-1 QGAWAPAGASEATGNEGTSGDARGGILVIHENKGLNDWVRSVAGRLAGAG
MSMEG_3558|M.smegmatis_MC2_155 QGAWAEA------------PDARGAVLVIHENKGLTDHIRSVAGRFAGIG
MAB_3265c|M.abscessus_ATCC_199 QGAWATA------------AEPRGTVLVIHENKGLNDWVRSVAGRLAGVG
TH_0693|M.thermoresistible__bu -------------------------VVLFVDAGGTRDLMREMADRLAGYG
:::. : * . ::* *
MMAR_3032|M.marinum_M YLALTPNMYARGGRARCITR---------VFRELLTKRGRALDDILAARD
MUL_2272|M.ulcerans_Agy99 YLALTPNMYARGGRARCITR---------VFRELLTKRGRALDDILAARD
Mb2080|M.bovis_AF2122/97 YVVLTPNMYARGGRARCITR---------VFRELLTKRGRALDDILAARD
Rv2054|M.tuberculosis_H37Rv YVVLTPNMYARGGRARCITR---------VFRELLTKRGRALDDILAARD
MLBr_01444|M.leprae_Br4923 YVAITPNLYSRGSRARCITR---------VMRELLTKRGRAFDDILATRD
MAV_0487|M.avium_104 YLTLAVDLFSAGGAARCLIS---------TMTAMIRGRGRAFADIAAARD
Mflv_3311|M.gilvum_PYR-GCK YSSLAIDLLSERGGTATFAD---------PAEATAALGARTPEDMVADLR
Mvan_3034|M.vanbaalenii_PYR-1 YSSLAIDLLSGQGGTATFAD---------PAEATAALGQRTPEDMVADLK
MSMEG_3558|M.smegmatis_MC2_155 YSALAIDLLSGQGGTGQFAD---------PADATAALSKIPPEEFVANLR
MAB_3265c|M.abscessus_ATCC_199 YSSLAIDLLSEEGGASAFKD---------PAEATGTLGRIAPERFIADLK
TH_0693|M.thermoresistible__bu YAVLVPDVYYRHGRWEPFDMRTVFGDPSERARLYRMIRSITPDMMETDAR
* :. :: . : . : :
MMAR_3032|M.marinum_M HLLAMAECSG-----QVGIAGFCMGGQFALILSPRG---FGASAPFYGT-
MUL_2272|M.ulcerans_Agy99 HLLAMAECSG-----QVGIAGFCMGGQFALILSPRG---FGASAPFYGT-
Mb2080|M.bovis_AF2122/97 HLLAMPECSG-----RVGIVGFCMGGQFALVLSPRG---FGATAPFYGT-
Rv2054|M.tuberculosis_H37Rv HLLAMPECSG-----RVGIVGFCMGGQFALVLSPRG---FGATAPFYGT-
MLBr_01444|M.leprae_Br4923 YLLAMPKCSG-----RVGIAGFCMGGRFALVMSPKG---FDASAPFYGT-
MAV_0487|M.avium_104 YLAGSADCTG-----KVGVIGFCMGGGFALLTANTG---YDAAAVNYG--
Mflv_3311|M.gilvum_PYR-GCK SGIAEVQRRTPDK--KVAAIGFCMGGGLVWRLLAAGTPELAAAFPFYG--
Mvan_3034|M.vanbaalenii_PYR-1 SGIAEVARRTPGK--KVAAIGFCMGGGLVWRLLAAGSPELAAAFPFYG--
MSMEG_3558|M.smegmatis_MC2_155 SGIDELSRRAPDR--KLAAVGFCMGGGLVWRLLAAGTPQLAAAVPFYG--
MAB_3265c|M.abscessus_ATCC_199 SGVDEILRRVPGK--PAGAVGFCFGGGLVWQLLAAGEPRLAAAAPFYG--
TH_0693|M.thermoresistible__bu AFFDFLQSRPEVKGDRFGVFGYCMGGRMSVTVAGRVPDRVAAAASFHAAG
. *:*:** : *: :.
MMAR_3032|M.marinum_M -----PLPRHLSETLDGACPIVASFGNRDPLGLGAPSRLREVTQAKQIPA
MUL_2272|M.ulcerans_Agy99 -----PLPRHLSETLDGACPIVASFGNRDPLGLGAPSRLREVTQAKQIPA
Mb2080|M.bovis_AF2122/97 -----PLPRHLSETLNGACPIVASFGTRDPLGIGAANRLRKVTAAKNIPA
Rv2054|M.tuberculosis_H37Rv -----PLPRHLSETLNGACPIVASFGTRDPLGIGAANRLRKVTAAKNIPA
MLBr_01444|M.leprae_Br4923 -----PLPRNLSETLNGACPIVASFGGRDPLGIGAPKRLRQATQTRHITT
MAV_0487|M.avium_104 -----QLPRHLDTALAGACPIVGSYGGRDPSLRGATRKLNEALTKAGIEH
Mflv_3311|M.gilvum_PYR-GCK -----PTPEAPDFAGSRDVAVLAFYGELDQRVNATEPDARAALEKAGLVH
Mvan_3034|M.vanbaalenii_PYR-1 -----PTPDNPDFAASKDVAVLGFYGELDQRVNATEPVAAAALQKAGLVH
MSMEG_3558|M.smegmatis_MC2_155 -----PTPDDPDFAGSKDVAVLAFYGALDQRVNATEPVARAALEKAGLVH
MAB_3265c|M.abscessus_ATCC_199 -----PLPDNPDFSRSK-AAVLAFYGELDERVTASKDQAADALRRGGLLH
TH_0693|M.thermoresistible__bu LVTDDPTSPHLLAERIKATVYVAGAQDDDGFTPAHAETLGKALTDAGVEH
. :. * . . :
MMAR_3032|M.marinum_M DIKGYPGAGHSFANKLPR-----QPLLRITGFGYNEAATEDAWGRVFAFF
MUL_2272|M.ulcerans_Agy99 DIEGYPGAGHSFANKLPR-----QPLLRITGFGYNEAATEDAWGRVFAFF
Mb2080|M.bovis_AF2122/97 DIKSYPGAGHSFANKLPG-----QPLVRIAGFGYNEAATEDAWRRVFEFF
Rv2054|M.tuberculosis_H37Rv DIKSYPGAGHSFANKLPG-----QPLVRIAGFGYNEAATEDAWRRVFEFF
MLBr_01444|M.leprae_Br4923 DIKVYPDAGHSFANKLPG-----QPLMRITGFGYNQAATEDAWSRVFAFF
MAV_0487|M.avium_104 DVKEYPAASHAFLNDDEAGPRILRPLLRVAGIGPEPDSAQDAWNRIAAFF
Mflv_3311|M.gilvum_PYR-GCK EIVIEPGANHAFFNDTGD--------------RYDPAAAADAWERTLAWL
Mvan_3034|M.vanbaalenii_PYR-1 ELVTEPGANHAFFNDTGD--------------RYDPAAAADAWSRTLDWL
MSMEG_3558|M.smegmatis_MC2_155 ELVTEPGANHAFFNDTGD--------------RYDPTAAADAWRRIQEWF
MAB_3265c|M.abscessus_ATCC_199 EIAVEPGADHAFFNDSGP--------------RYNASAAVDAWQRLLGWL
TH_0693|M.thermoresistible__bu TIEFYP-AGHGFAVPDNLP--------------YDEQAAERHWDALRALF
: * *.*.* : :: * :
MMAR_3032|M.marinum_M GEHLAAGTSRG-
MUL_2272|M.ulcerans_Agy99 GEHLAAGTSGN-
Mb2080|M.bovis_AF2122/97 GQHLRAGSPGEP
Rv2054|M.tuberculosis_H37Rv GQHLRAGSPGEP
MLBr_01444|M.leprae_Br4923 DKHLRTD-----
MAV_0487|M.avium_104 ATHLH-------
Mflv_3311|M.gilvum_PYR-GCK TAHVG-------
Mvan_3034|M.vanbaalenii_PYR-1 AAHVG-------
MSMEG_3558|M.smegmatis_MC2_155 TAHLA-------
MAB_3265c|M.abscessus_ATCC_199 GQHIG-------
TH_0693|M.thermoresistible__bu DRELSG------
.: