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TITISTPDGPIDALLSTPTGSGPWPGVVIIHDAIGYGPDNELVSERVAQAGYLAITPNLYSRGGRARCIT RMFRDLLTQRGRALDDILAARDHLKSLPECTGTVGVVGFCSGGQFALIMGPKGFAASAPFYGTPLPRHLD RTLDASCPIVASFGRRDPLGIGAPARLRRVVEAKNIPADIKVYPSAGHSFANILPAQPLLRVTGFGYDEA ATTDAWTRVFAFFDEHLKPKTAGQA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2444 | - | - | 100% (236) | dienelactone hydrolase family protein |
| M. smegmatis MC2 155 | MSMEG_2669 | - | 3e-17 | 30.25% (238) | hydrolase |
| M. smegmatis MC2 155 | MSMEG_3558 | - | 4e-10 | 26.67% (240) | carboxymethylenebutenolidase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2080 | - | 1e-103 | 71.37% (234) | hypothetical protein Mb2080 |
| M. gilvum PYR-GCK | Mflv_4008 | - | 6e-18 | 28.86% (246) | dienelactone hydrolase |
| M. tuberculosis H37Rv | Rv2054 | - | 1e-103 | 71.37% (234) | hypothetical protein Rv2054 |
| M. leprae Br4923 | MLBr_01444 | - | 6e-98 | 70.48% (227) | putative dienelactone hydrolase |
| M. abscessus ATCC 19977 | MAB_3265c | - | 8e-12 | 27.31% (238) | hypothetical protein MAB_3265c |
| M. marinum M | MMAR_3032 | - | 1e-107 | 75.86% (232) | hypothetical protein MMAR_3032 |
| M. avium 104 | MAV_2443 | - | 5e-83 | 68.84% (199) | dienelactone hydrolase family protein |
| M. thermoresistible (build 8) | TH_0693 | - | 1e-14 | 28.98% (245) | PROBABLE ALANINE RICH HYDROLASE |
| M. ulcerans Agy99 | MUL_2272 | - | 1e-107 | 75.54% (233) | hypothetical protein MUL_2272 |
| M. vanbaalenii PYR-1 | Mvan_2379 | - | 6e-17 | 28.79% (257) | dienelactone hydrolase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4008|M.gilvum_PYR-GCK ---------------------------------------MPTITDTVTTT
Mvan_2379|M.vanbaalenii_PYR-1 ---------------------------------------MPRITDTVTTA
TH_0693|M.thermoresistible__bu --------------------------------------------------
Mb2080|M.bovis_AF2122/97 -----------------------------------------MTTIEIDAP
Rv2054|M.tuberculosis_H37Rv -----------------------------------------MTTIEIDAP
MMAR_3032|M.marinum_M -----------------MTPTYGNCARVPRTVATRLQLDDAMTTIDIDTP
MUL_2272|M.ulcerans_Agy99 -----------------------------------------MTTIDIDTP
MLBr_01444|M.leprae_Br4923 -----------------------------------------MTKIQIDAP
MAV_2443|M.avium_104 --------------------------------------------------
MSMEG_2444|M.smegmatis_MC2_155 ------------------------------------------MTITISTP
MAB_3265c|M.abscessus_ATCC_199 MTPLQRYIAEEIATDHIEGLLTRREAFRRLALLGVGATAAGALISACGTG
Mflv_4008|M.gilvum_PYR-GCK DGSCPVTLHTPDGDGP-------------WRG------------------
Mvan_2379|M.vanbaalenii_PYR-1 DGDCPVSLHTPDGGGP-------------WRG------------------
TH_0693|M.thermoresistible__bu -----VTLHTPDGAGP-------------WPG------------------
Mb2080|M.bovis_AF2122/97 AGPIDALLGLPPGQGP-------------WPG------------------
Rv2054|M.tuberculosis_H37Rv AGPIDALLGLPPGQGP-------------WPG------------------
MMAR_3032|M.marinum_M AGPIDALLGVPTGEGP-------------WPG------------------
MUL_2272|M.ulcerans_Agy99 AGPIDALLGVPTGEGP-------------WPG------------------
MLBr_01444|M.leprae_Br4923 DGPIDALLSVPPGPEP-------------WPG------------------
MAV_2443|M.avium_104 --------------------------------------------------
MSMEG_2444|M.smegmatis_MC2_155 DGPIDALLSTPTGSGP-------------WPG------------------
MAB_3265c|M.abscessus_ATCC_199 NKPVAAPAPANSGAPPPGMDNVVVTEPITWRGPNGTLQGAWATAAEPRGT
Mflv_4008|M.gilvum_PYR-GCK IVMYPDAGGVRPTFRTMADQLAGHGYAVLLPDVYYREGDWAPFTMSTVFG
Mvan_2379|M.vanbaalenii_PYR-1 IVMYPDAGGARPTFRAMADKLAGYGYAVLVPDVYYREGDWAPFTIATAFD
TH_0693|M.thermoresistible__bu VVLFVDAGGTRDLMREMADRLAGYGYAVLVPDVYYRHGRWEPFDMRTVFG
Mb2080|M.bovis_AF2122/97 VVVVHDAVGYVPDNKLISERIARAGYVVLTPNMYARGG--RARCITRVFR
Rv2054|M.tuberculosis_H37Rv VVVVHDAVGYVPDNKLISERIARAGYVVLTPNMYARGG--RARCITRVFR
MMAR_3032|M.marinum_M VVVVHDAIGYAPDNEAISERIAAAGYLALTPNMYARGG--RARCITRVFR
MUL_2272|M.ulcerans_Agy99 VVVVHDAIGYAPDNEAISERIAAAGYLALTPNMYARGG--RARCITRVFR
MLBr_01444|M.leprae_Br4923 VVVIHDAIGYEPDKESTNNHIAMAGYVAITPNLYSRGS--RARCITRVMR
MAV_2443|M.avium_104 --MIHDAFGYGRDKQSINDRIARAGYLALTPNMYARGG--LVRCITRVMK
MSMEG_2444|M.smegmatis_MC2_155 VVIIHDAIGYGPDNELVSERVAQAGYLAITPNLYSRGG--RARCITRMFR
MAB_3265c|M.abscessus_ATCC_199 VLVIHENKGLNDWVRSVAGRLAGVGYSSLAIDLLSEEGGASAFKDPAEAT
: : * . ::* ** : :: . .
Mflv_4008|M.gilvum_PYR-GCK DAAERRRLFGMISKVTPERMESDAVAFFDYLADRPEVSGETFGTTGYCMG
Mvan_2379|M.vanbaalenii_PYR-1 DDVERRRLFSFMAKVTPEVMAADATAFFDYLAGRPEVRGDTFGTTGYCMG
TH_0693|M.thermoresistible__bu DPSERARLYRMIRSITPDMMETDARAFFDFLQSRPEVKGDRFGVFGYCMG
Mb2080|M.bovis_AF2122/97 ELLTKR-----------GRALDDILAARDHLLAMPECSG-RVGIVGFCMG
Rv2054|M.tuberculosis_H37Rv ELLTKR-----------GRALDDILAARDHLLAMPECSG-RVGIVGFCMG
MMAR_3032|M.marinum_M ELLTKR-----------GRALDDILAARDHLLAMAECSG-QVGIAGFCMG
MUL_2272|M.ulcerans_Agy99 ELLTKR-----------GRALDDILAARDHLLAMAECSG-QVGIAGFCMG
MLBr_01444|M.leprae_Br4923 ELLTKR-----------GRAFDDILATRDYLLAMPKCSG-RVGIAGFCMG
MAV_2443|M.avium_104 ELAAQR-----------GRALDDILAARDHLQAMPECTG-RVGIAGFCMG
MSMEG_2444|M.smegmatis_MC2_155 DLLTQR-----------GRALDDILAARDHLKSLPECTG-TVGVVGFCSG
MAB_3265c|M.abscessus_ATCC_199 GTLGRIAP---------ERFIADLKSGVDEILRR--VPGKPAGAVGFCFG
: * : * : * * *:* *
Mflv_4008|M.gilvum_PYR-GCK GRTSLVVAGRVPQRVAAAMSFHGGGLVTDDAESPHLLADRIRAAVYVGAA
Mvan_2379|M.vanbaalenii_PYR-1 GRTSLVLAGRLPDRVSAAMSFHGGGLATDDPHSPHLLADQMRAAVYVGAA
TH_0693|M.thermoresistible__bu GRMSVTVAGRVPDRVAAAASFHAAGLVTDDPTSPHLLAERIKATVYVAGA
Mb2080|M.bovis_AF2122/97 GQFALVLS---PRGFGATAPFYG------TPLPRHLSETLNGACPIVASF
Rv2054|M.tuberculosis_H37Rv GQFALVLS---PRGFGATAPFYG------TPLPRHLSETLNGACPIVASF
MMAR_3032|M.marinum_M GQFALILS---PRGFGASAPFYG------TPLPRHLSETLDGACPIVASF
MUL_2272|M.ulcerans_Agy99 GQFALILS---PRGFGASAPFYG------TPLPRHLSETLDGACPIVASF
MLBr_01444|M.leprae_Br4923 GRFALVMS---PKGFDASAPFYG------TPLPRNLSETLNGACPIVASF
MAV_2443|M.avium_104 GRFALVMS---PKGFGASAPFYG------TPLPGNLDEVLEGACPVVASF
MSMEG_2444|M.smegmatis_MC2_155 GQFALIMG---PKGFAASAPFYG------TPLPRHLDRTLDASCPIVASF
MAB_3265c|M.abscessus_ATCC_199 GGLVWQLLAAGEPRLAAAAPFYG-------PLPDNPDFSRS-KAAVLAFY
* : . *: .*:. . . : :.
Mflv_4008|M.gilvum_PYR-GCK HNDNSFTRADGETLDKALSAAGVEHTVDWYS-AQHGFAVPDNGP------
Mvan_2379|M.vanbaalenii_PYR-1 RSDRSFTTEDGERLEKALTSTGVEHTIEWYP-AFHGFAVPDNGP------
TH_0693|M.thermoresistible__bu QDDDGFTPAHAETLGKALTDAGVEHTIEFYP-AGHGFAVPDNLP------
Mb2080|M.bovis_AF2122/97 GTRDPLGIGAANRLRKVTAAKNIPADIKSYPGAGHSFANKLPGQPLVRIA
Rv2054|M.tuberculosis_H37Rv GTRDPLGIGAANRLRKVTAAKNIPADIKSYPGAGHSFANKLPGQPLVRIA
MMAR_3032|M.marinum_M GNRDPLGLGAPSRLREVTQAKQIPADIKGYPGAGHSFANKLPRQPLLRIT
MUL_2272|M.ulcerans_Agy99 GNRDPLGLGAPSRLREVTQAKQIPADIEGYPGAGHSFANKLPRQPLLRIT
MLBr_01444|M.leprae_Br4923 GGRDPLGIGAPKRLRQATQTRHITTDIKVYPDAGHSFANKLPGQPLMRIT
MAV_2443|M.avium_104 GGRDLTGKGAPEKLRKVTADKNITADIKVYPEAGHSFANELPAQPLLRIA
MSMEG_2444|M.smegmatis_MC2_155 GRRDPLGIGAPARLRRVVEAKNIPADIKVYPSAGHSFANILPAQPLLRVT
MAB_3265c|M.abscessus_ATCC_199 GELDERVTASKDQAADALRRGGLLHEIAVEPGADHAFFNDSGPR------
. : : . * *.*
Mflv_4008|M.gilvum_PYR-GCK ---YDESAARRHWDAMQSFFAAHLV-------
Mvan_2379|M.vanbaalenii_PYR-1 ---YDEPAARRHWEAMRSFFATHLV-------
TH_0693|M.thermoresistible__bu ---YDEQAAERHWDALRALFDRELSG------
Mb2080|M.bovis_AF2122/97 GFGYNEAATEDAWRRVFEFFGQHLRAGSPGEP
Rv2054|M.tuberculosis_H37Rv GFGYNEAATEDAWRRVFEFFGQHLRAGSPGEP
MMAR_3032|M.marinum_M GFGYNEAATEDAWGRVFAFFGEHLAAGTSRG-
MUL_2272|M.ulcerans_Agy99 GFGYNEAATEDAWGRVFAFFGEHLAAGTSGN-
MLBr_01444|M.leprae_Br4923 GFGYNQAATEDAWSRVFAFFDKHLRTD-----
MAV_2443|M.avium_104 GFGYNEEATEDAWRRVFSFFGEHLAATP----
MSMEG_2444|M.smegmatis_MC2_155 GFGYDEAATTDAWTRVFAFFDEHLKPKTAGQA
MAB_3265c|M.abscessus_ATCC_199 ---YNASAAVDAWQRLLGWLGQHIG-------
*: *: * : : .: