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QRYIAEEIATDHVDGLLTRREAMRRLALLGVGGAAATALIAACGQNRQPETAGTSPEAPGSPASSTADRA APPPGMDRALPTTPVTWAGPAGELQGAWAPAGASEATGNEGTSGDARGGILVIHENKGLNDWVRSVAGRL AGAGYSSLAIDLLSGQGGTATFADPAEATAALGQRTPEDMVADLKSGIAEVARRTPGKKVAAIGFCMGGG LVWRLLAAGSPELAAAFPFYGPTPDNPDFAASKDVAVLGFYGELDQRVNATEPVAAAALQKAGLVHELVT EPGANHAFFNDTGDRYDPAAAADAWSRTLDWLAAHVG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3034 | - | - | 100% (318) | dienelactone hydrolase |
| M. vanbaalenii PYR-1 | Mvan_4080 | - | 4e-08 | 30.04% (223) | dienelactone hydrolase |
| M. vanbaalenii PYR-1 | Mvan_2379 | - | 4e-08 | 26.85% (216) | dienelactone hydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2080 | - | 5e-09 | 25.21% (234) | hypothetical protein Mb2080 |
| M. gilvum PYR-GCK | Mflv_3311 | - | 1e-144 | 80.82% (318) | dienelactone hydrolase |
| M. tuberculosis H37Rv | Rv2054 | - | 5e-09 | 25.21% (234) | hypothetical protein Rv2054 |
| M. leprae Br4923 | MLBr_01444 | - | 4e-09 | 25.76% (229) | putative dienelactone hydrolase |
| M. abscessus ATCC 19977 | MAB_3265c | - | 1e-112 | 63.52% (318) | hypothetical protein MAB_3265c |
| M. marinum M | MMAR_1955 | - | 2e-11 | 27.57% (214) | alanine rich hydrolase |
| M. avium 104 | MAV_0487 | - | 2e-21 | 34.11% (214) | dienelactone hydrolase family protein |
| M. smegmatis MC2 155 | MSMEG_3558 | - | 1e-126 | 70.22% (319) | carboxymethylenebutenolidase |
| M. thermoresistible (build 8) | TH_3710 | - | 5e-10 | 28.57% (210) | PUTATIVE - |
| M. ulcerans Agy99 | MUL_2177 | - | 1e-11 | 27.57% (214) | alanine rich hydrolase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2080|M.bovis_AF2122/97 ----MTTIEID----APAG-------------------------------
Rv2054|M.tuberculosis_H37Rv ----MTTIEID----APAG-------------------------------
MLBr_01444|M.leprae_Br4923 ----MTKIQID----APDG-------------------------------
MAV_0487|M.avium_104 ----MTDIDLTDLAAAHAGSQ-----------------------------
MMAR_1955|M.marinum_M ----MPIISDS--VSTPDG-------------------------------
MUL_2177|M.ulcerans_Agy99 ----MPIISDS--VSTPDG-------------------------------
Mvan_3034|M.vanbaalenii_PYR-1 ---MQRYIAEEIATDHVDGLLTRREAMRRLALLGVGGAAATALIAACGQN
Mflv_3311|M.gilvum_PYR-GCK MTPLQRYIAEEIATDHVDGLMSRREALRRLALLGVGGAAATALIAACGQN
MSMEG_3558|M.smegmatis_MC2_155 MTPLQRYIAEEIATDHLDGLMSRREALRRLGLLGLSTAAATAVIAACSER
MAB_3265c|M.abscessus_ATCC_199 MTPLQRYIAEEIATDHIEGLLTRREAFRRLALLGVGATAAGALISACGTG
TH_3710|M.thermoresistible__bu -------MGEYIAVQTKSGD------------------------------
: *
Mb2080|M.bovis_AF2122/97 ----------------------------PIDALLGLPPGQGPWPG-----
Rv2054|M.tuberculosis_H37Rv ----------------------------PIDALLGLPPGQGPWPG-----
MLBr_01444|M.leprae_Br4923 ----------------------------PIDALLSVPPGPEPWPG-----
MAV_0487|M.avium_104 ----------------------------PLRGYLATPSGTGPWPG-----
MMAR_1955|M.marinum_M ----------------------------TCPVRLFTPAGPGPWPG-----
MUL_2177|M.ulcerans_Agy99 ----------------------------TCPVRLFTPAGPGPWPG-----
Mvan_3034|M.vanbaalenii_PYR-1 RQPETAGTS--PEAPGSPASSTADRAAPPPGMDRALPTTPVTWAGPAGEL
Mflv_3311|M.gilvum_PYR-GCK QQ--SAETT--AEP--SPTSDTPTSDAPPPGMDAALPTEPVTWAGPKGEL
MSMEG_3558|M.smegmatis_MC2_155 EQTTTATTENTTDTAGPPTTETQPPSAEPPGMQTALPTAAVTWAGPTGEL
MAB_3265c|M.abscessus_ATCC_199 NKPVAAPAP-------------ANSGAPPPGMDNVVVTEPITWRGPNGTL
TH_3710|M.thermoresistible__bu ----------------------------TYDAYLAVP-EQGSGPG-----
. . *
Mb2080|M.bovis_AF2122/97 -------------------------VVVVHDAVGYVPDNKLISERIARAG
Rv2054|M.tuberculosis_H37Rv -------------------------VVVVHDAVGYVPDNKLISERIARAG
MLBr_01444|M.leprae_Br4923 -------------------------VVVIHDAIGYEPDKESTNNHIAMAG
MAV_0487|M.avium_104 -------------------------VVLIHEVFGIDDVMRRHTDRLAGLG
MMAR_1955|M.marinum_M -------------------------VIMFPDAGGVRETFEQMAATLAGHG
MUL_2177|M.ulcerans_Agy99 -------------------------VIMFPDAGGVRETFEQMAATLAGHG
Mvan_3034|M.vanbaalenii_PYR-1 QGAWAPAGASEATGNEGTSGDARGGILVIHENKGLNDWVRSVAGRLAGAG
Mflv_3311|M.gilvum_PYR-GCK QGAWAQA------------AEPRGGILVIHENKGLNDWTRSVAGRLAGAG
MSMEG_3558|M.smegmatis_MC2_155 QGAWAEA------------PDARGAVLVIHENKGLTDHIRSVAGRFAGIG
MAB_3265c|M.abscessus_ATCC_199 QGAWATA------------AEPRGTVLVIHENKGLNDWVRSVAGRLAGVG
TH_3710|M.thermoresistible__bu -------------------------LVLLQEIFGVNGYMRDMADRFAQEG
:::. : * . :* *
Mb2080|M.bovis_AF2122/97 YVVLTPNMYAR-------------GGRARCITRVFRELLTKRGRALDDIL
Rv2054|M.tuberculosis_H37Rv YVVLTPNMYAR-------------GGRARCITRVFRELLTKRGRALDDIL
MLBr_01444|M.leprae_Br4923 YVAITPNLYSR-------------GSRARCITRVMRELLTKRGRAFDDIL
MAV_0487|M.avium_104 YLTLAVDLFSA-------------GGAARCLISTMTAMIRGRGRAFADIA
MMAR_1955|M.marinum_M YVVLLPDVYYREGDWTPFAMETVFGDADERARLMFMLGTLTPDRVTRDAG
MUL_2177|M.ulcerans_Agy99 YVVLLPDVYYREGDWTPFAMETVFGDADERARLMFMLGTLTPDRVTRDAG
Mvan_3034|M.vanbaalenii_PYR-1 YSSLAIDLLSGQ------------GGTATFADPAEATAALGQRTPEDMVA
Mflv_3311|M.gilvum_PYR-GCK YSSLAIDLLSER------------GGTATFADPAEATAALGARTPEDMVA
MSMEG_3558|M.smegmatis_MC2_155 YSALAIDLLSGQ------------GGTGQFADPADATAALSKIPPEEFVA
MAB_3265c|M.abscessus_ATCC_199 YSSLAIDLLSEE------------GGASAFKDPAEATGTLGRIAPERFIA
TH_3710|M.thermoresistible__bu YVAIVPDLFWRSERR-----VELEYDEAGVARGLQLAGELDFALAVDDID
* : :: .
Mb2080|M.bovis_AF2122/97 AARDHLLAMP-ECSG-RVGIVGFCMGGQFALVLS---PRGFGATAPFYGT
Rv2054|M.tuberculosis_H37Rv AARDHLLAMP-ECSG-RVGIVGFCMGGQFALVLS---PRGFGATAPFYGT
MLBr_01444|M.leprae_Br4923 ATRDYLLAMP-KCSG-RVGIAGFCMGGRFALVMS---PKGFDASAPFYGT
MAV_0487|M.avium_104 AARDYLAGSA-DCTG-KVGVIGFCMGGGFALLTA---NTGYDAAAVNYG-
MMAR_1955|M.marinum_M AYFDYLATRP-QVSGERFGVCGYCMGGRISVLLAGRQPDRVAAAASFHGG
MUL_2177|M.ulcerans_Agy99 AYFDYLATRP-QVSGERFGVCGYCMGGRISVLLAGRQPDRVAAAASFHGG
Mvan_3034|M.vanbaalenii_PYR-1 DLKSGIAEVARRTPGKKVAAIGFCMGGGLVWRLLAAGSPELAAAFPFYG-
Mflv_3311|M.gilvum_PYR-GCK DLRSGIAEVQRRTPDKKVAAIGFCMGGGLVWRLLAAGTPELAAAFPFYG-
MSMEG_3558|M.smegmatis_MC2_155 NLRSGIDELSRRAPDRKLAAVGFCMGGGLVWRLLAAGTPQLAAAVPFYG-
MAB_3265c|M.abscessus_ATCC_199 DLKSGVDEILRRVPGKPAGAVGFCFGGGLVWQLLAAGEPRLAAAAPFYG-
TH_3710|M.thermoresistible__bu DAVTALRALPGQAGG--VGVLGYCMGGLLAYLSA--LTLQIDCAVSYYGV
: . . *:*:** : .: :*
Mb2080|M.bovis_AF2122/97 ------PLPRHLSETLNGACPIVASFGTRDPLGIGAANRLRKVTAAKNIP
Rv2054|M.tuberculosis_H37Rv ------PLPRHLSETLNGACPIVASFGTRDPLGIGAANRLRKVTAAKNIP
MLBr_01444|M.leprae_Br4923 ------PLPRNLSETLNGACPIVASFGGRDPLGIGAPKRLRQATQTRHIT
MAV_0487|M.avium_104 ------QLPRHLDTALAGACPIVGSYGGRDPSLRGATRKLNEALTKAGIE
MMAR_1955|M.marinum_M GLVTDNPDSPHLLADRMTARLYVGGAQNDPSFTTDHAEQLEKALTAAGVE
MUL_2177|M.ulcerans_Agy99 DLVTDNPDSPHLLADRMTARLYVGGATNDPSFTTDHAEQLEKALTAAGVE
Mvan_3034|M.vanbaalenii_PYR-1 ------PTPDNPDFAASKDVAVLGFYGELDQRVNATEPVAAAALQKAGLV
Mflv_3311|M.gilvum_PYR-GCK ------PTPEAPDFAGSRDVAVLAFYGELDQRVNATEPDARAALEKAGLV
MSMEG_3558|M.smegmatis_MC2_155 ------PTPDDPDFAGSKDVAVLAFYGALDQRVNATEPVARAALEKAGLV
MAB_3265c|M.abscessus_ATCC_199 ------PLPDNPDFSRSK-AAVLAFYGELDERVTASKDQAADALRRGGLL
TH_3710|M.thermoresistible__bu G------VHEYLGRAAELQVPMVFHLAELDAFCPEPARRAIRNAFAGNDR
:
Mb2080|M.bovis_AF2122/97 ADIKSYPGAGHSFANKLPG-----QPLVRIAGFGYNEAATEDAWRRVFEF
Rv2054|M.tuberculosis_H37Rv ADIKSYPGAGHSFANKLPG-----QPLVRIAGFGYNEAATEDAWRRVFEF
MLBr_01444|M.leprae_Br4923 TDIKVYPDAGHSFANKLPG-----QPLMRITGFGYNQAATEDAWSRVFAF
MAV_0487|M.avium_104 HDVKEYPAASHAFLNDDEAGPRILRPLLRVAGIGPEPDSAQDAWNRIAAF
MMAR_1955|M.marinum_M HTIEWYPGAHGFAVPDNPP---------------YDEACAQRHWTAMTDL
MUL_2177|M.ulcerans_Agy99 HTIEWYPGAHGFAVPDNPP---------------YDEACAQRHWTAMTDL
Mvan_3034|M.vanbaalenii_PYR-1 HELVTEPGANHAFFNDTGD--------------RYDPAAAADAWSRTLDW
Mflv_3311|M.gilvum_PYR-GCK HEIVIEPGANHAFFNDTGD--------------RYDPAAAADAWERTLAW
MSMEG_3558|M.smegmatis_MC2_155 HELVTEPGANHAFFNDTGD--------------RYDPTAAADAWRRIQEW
MAB_3265c|M.abscessus_ATCC_199 HEIAVEPGADHAFFNDSGP--------------RYNASAAVDAWQRLLGW
TH_3710|M.thermoresistible__bu VRVYEYPEVDHAFATHGRD--------------SFDPVSTAMAYSRTLEL
: * . . : .: :
Mb2080|M.bovis_AF2122/97 FGQHLRAGSPGEP-------------------------------------
Rv2054|M.tuberculosis_H37Rv FGQHLRAGSPGEP-------------------------------------
MLBr_01444|M.leprae_Br4923 FDKHLRTD------------------------------------------
MAV_0487|M.avium_104 FATHLH--------------------------------------------
MMAR_1955|M.marinum_M FAATLSR-------------------------------------------
MUL_2177|M.ulcerans_Agy99 FAATLSR-------------------------------------------
Mvan_3034|M.vanbaalenii_PYR-1 LAAHVG--------------------------------------------
Mflv_3311|M.gilvum_PYR-GCK LTAHVG--------------------------------------------
MSMEG_3558|M.smegmatis_MC2_155 FTAHLA--------------------------------------------
MAB_3265c|M.abscessus_ATCC_199 LGQHIG--------------------------------------------
TH_3710|M.thermoresistible__bu LRQTIGPRYDLSALWDQHIHHEFVTRDVPATMATMVDEPYVNHVPTLTGG
: :
Mb2080|M.bovis_AF2122/97 --------------------------------------------------
Rv2054|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01444|M.leprae_Br4923 --------------------------------------------------
MAV_0487|M.avium_104 --------------------------------------------------
MMAR_1955|M.marinum_M --------------------------------------------------
MUL_2177|M.ulcerans_Agy99 --------------------------------------------------
Mvan_3034|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3311|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_3558|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3265c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3710|M.thermoresistible__bu VGKTDLARFYADHFVHANPADMRAIPVSRTVGADRIVEEQVLCFTHDREI
Mb2080|M.bovis_AF2122/97 --------------------------------------------------
Rv2054|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01444|M.leprae_Br4923 --------------------------------------------------
MAV_0487|M.avium_104 --------------------------------------------------
MMAR_1955|M.marinum_M --------------------------------------------------
MUL_2177|M.ulcerans_Agy99 --------------------------------------------------
Mvan_3034|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3311|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_3558|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3265c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3710|M.thermoresistible__bu DWMLPGVAPTGRYVEIPLVAVVTFRGDKLYNEHIYWDQASVLAQLGLLDP
Mb2080|M.bovis_AF2122/97 -------------------------------------
Rv2054|M.tuberculosis_H37Rv -------------------------------------
MLBr_01444|M.leprae_Br4923 -------------------------------------
MAV_0487|M.avium_104 -------------------------------------
MMAR_1955|M.marinum_M -------------------------------------
MUL_2177|M.ulcerans_Agy99 -------------------------------------
Mvan_3034|M.vanbaalenii_PYR-1 -------------------------------------
Mflv_3311|M.gilvum_PYR-GCK -------------------------------------
MSMEG_3558|M.smegmatis_MC2_155 -------------------------------------
MAB_3265c|M.abscessus_ATCC_199 -------------------------------------
TH_3710|M.thermoresistible__bu SGLPVAGVGQSRKLLDKTLPSNELIPNWATGVPVPTP