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MDNSGPSRTALATAYARACHQFADSPPIFADPLAARLLGVTEANLDDLSRHPAGHPATVARDRPRRLFFA ARSRFADDVTARAVAAGVRQVVVLGAGLDTAAYRNSHPDVHVFEVDHPQTQAWKRERLAATGIDIPATAT LVPVDFETQTLASELESASFSRTEPAVFVWLGVIFYLTPDAAGSTLDYIAGQARPVDLVFDYLQPAETDE DRADLKNRAARLARAGEPLVNYLTSDELHRQLADFGFRVVEDLSGNELIGRYPHGAPVLDERALRASRIV HARC
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3424 | - | - | 100% (284) | transcriptional regulator, MerR family protein |
| M. smegmatis MC2 155 | MSMEG_1482 | - | 6e-17 | 34.39% (221) | methyltransferase |
| M. smegmatis MC2 155 | MSMEG_1501 | - | 2e-15 | 31.10% (283) | methyltransferase, putative, family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0151 | - | 9e-19 | 30.31% (287) | hypothetical protein Mb0151 |
| M. gilvum PYR-GCK | Mflv_5025 | - | 9e-20 | 33.05% (236) | putative methyltransferase |
| M. tuberculosis H37Rv | Rv0146 | - | 1e-18 | 30.31% (287) | hypothetical protein Rv0146 |
| M. leprae Br4923 | MLBr_02640 | - | 9e-17 | 28.42% (285) | hypothetical protein MLBr_02640 |
| M. abscessus ATCC 19977 | MAB_2253 | - | 1e-34 | 38.35% (279) | hypothetical protein MAB_2253 |
| M. marinum M | MMAR_1068 | - | 4e-18 | 36.04% (222) | O-methyltransferase |
| M. avium 104 | MAV_5149 | - | 1e-17 | 29.57% (301) | methyltransferase, putative, family protein |
| M. thermoresistible (build 8) | TH_0301 | - | 2e-17 | 30.98% (255) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_4762 | - | 5e-18 | 28.17% (284) | O-methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_1346 | - | 3e-18 | 31.74% (230) | putative methyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
TH_0301|M.thermoresistible__bu --MX-------------GG-----------ASRDPKELINDPFAAPLVRA
Mvan_1346|M.vanbaalenii_PYR-1 --MARTDNDTWDLASSVGATATMVAAARAVATRAPRPVIDDPFAAPLVQA
Mflv_5025|M.gilvum_PYR-GCK --MARTPDDSWDLASSVGATATMVAAGRAVASADPDPLINDPYAEPLVRA
MMAR_1068|M.marinum_M --MTRTDQDSWDLASSVGATATMVAAARALASAEANPIIDDPFAAPLVRA
Mb0151|M.bovis_AF2122/97 ---MRTHDDTWDIKTSVGATAVMVAAARAVETDRPDPLIRDPYARLLVTN
Rv0146|M.tuberculosis_H37Rv ---MRTHDDTWDIKTSVGATAVMVAAARAVETDRPDPLIRDPYARLLVTN
MUL_4762|M.ulcerans_Agy99 ---MRTHDDTWDIRTSVGATAVMVAAARAVETSKPEPLIRDPYARMLVTN
MLBr_02640|M.leprae_Br4923 ---MRTHDDTWDIKTSVGTTAVMVAAARAAETDRPDALIRDPYAKLLVTN
MAV_5149|M.avium_104 MSSLRTHDDTWDIKSSVGTTAVMVAAARAVETEQPDPLIRDPYAKLLVTN
MSMEG_3424|M.smegmatis_MC2_155 ------------MDN--SG-PSRTALATAYARACHQFADSPPIFADPLAA
MAB_2253|M.abscessus_ATCC_1997 ------------MSNPAAGKPDHTALRTALWRALHVELDPPPHVLTDLVG
. * :
TH_0301|M.thermoresistible__bu VGIDFFTRIADGELTVADLDP---QSAPRVQANIDEVAVRTRFFDDHFAA
Mvan_1346|M.vanbaalenii_PYR-1 VGVDFFTRLATGELTTEELDTNDAESPVGMSRFADAMAARTRFFDDFFAE
Mflv_5025|M.gilvum_PYR-GCK VGLDFFTRMLDGELDLSVFPD---SSPERAQAMIDGMAVRTRFFDDCCLA
MMAR_1068|M.marinum_M VGLDFFTRLAEGEIDH---DE---QAQRDRQLVADSIAVRTRFFDDFFLD
Mb0151|M.bovis_AF2122/97 AGAGAIWEAMLDPTLVAKAAAIDAETAAIVAYLRSYQAVRTNFFDTYFAS
Rv0146|M.tuberculosis_H37Rv AGAGAIWEAMLDPTLVAKAAAIDAETAAIVAYLRSYQAVRTNFFDTYFAS
MUL_4762|M.ulcerans_Agy99 ANAGVIWEAMLDQEMVAKVEAIDAETAATVEHMRSYQAVRTNFFDTYFAD
MLBr_02640|M.leprae_Br4923 TGAGALWEAMLDPSMVAKVEAIDAEAAAMVEHMRSYQAVRTNFFDTYFNN
MAV_5149|M.avium_104 SGAGVLWEAMLDPDIAARVEALDEESAAHLHHMRGYQAVRTHFFDTYFAD
MSMEG_3424|M.smegmatis_MC2_155 RLLGVTEANLDDLSRHPAGHP---ATVARDRPRRLFFAARSRFADDVTAR
MAB_2253|M.abscessus_ATCC_1997 LQLAAPEE---DWRERPDMDP---HGTVDSR---LGMVARARFVEDLVKR
. ..*:.* :
TH_0301|M.thermoresistible__bu ATARG---IRQAVILAAGLDARAYRLRWP-DGTVVYEIDQPRVIEFKTRT
Mvan_1346|M.vanbaalenii_PYR-1 AMRAGPPPIRQGVILASGLDARAYRLSWP-QDMVLFEIDQPEVLTFKAAT
Mflv_5025|M.gilvum_PYR-GCK AASAG---VRQVVILAAGLDARTYRLPWP-DGTVVYELDQPDVIAFKTQT
MMAR_1068|M.marinum_M AARRG---VRQSVILAAGLDARAYRLPWP-SGSVVYEVDQPDVIDFKDTT
Mb0151|M.bovis_AF2122/97 AVAAG---IRQVVILASGLDSRAYRLDWP-AGTIVYEIDQPKVLSYKSTT
Rv0146|M.tuberculosis_H37Rv AVAAG---IRQVVILASGLDSRAYRLDWP-AGTIVYEIDQPKVLSYKSTT
MUL_4762|M.ulcerans_Agy99 AVAAG---IRQVVILASGLDSRAYRLDWP-AGTTVYEIDQPQVLAYKSAT
MLBr_02640|M.leprae_Br4923 AVIDG---IRQFVILASGLDSRAYRLDWP-TGTTVYEIDQPKVLAYKSTT
MAV_5149|M.avium_104 AVAAG---IRQIVILASGLDSRAYRLDWP-AGTTVYEIDQPQVLAYKSTT
MSMEG_3424|M.smegmatis_MC2_155 AVAAG---VRQVVVLGAGLDTAAYRNSHP--DVHVFEVDHPQTQAWKRER
MAB_2253|M.abscessus_ATCC_1997 RAAEG---VGQYVILGAGLDTFVQRHPDAGERLTVFEVDRPETQAWKRKR
* : * *:*.:***: . * . ::*:*:* . :*
TH_0301|M.thermoresistible__bu LARLGAEPTAERRTVAADLRH--DWPAALTAAGFDPAAPTVWIAEGLFGY
Mvan_1346|M.vanbaalenii_PYR-1 LADLGVRPSTKLATVAVDLRN--DWPAALAEAGFDASAPTAWIAEGLLGY
Mflv_5025|M.gilvum_PYR-GCK LRNLGAEPAATQRPVPVDLRE--DWPAALRAAGFDATRPTAWLAEGLLIY
MMAR_1068|M.marinum_M MSALGAVPTATRRTVRVDLRD--DWPAALRHNGFDTTQPTAWSAEGLLMY
Mb0151|M.bovis_AF2122/97 LAENGVTPSAGRREVPADLRQ--DWPAALRDAGFDPTARTAWLAEGLLMY
Rv0146|M.tuberculosis_H37Rv LAENGVTPSAGRREVPADLRQ--DWPAALRDAGFDPTARTAWLAEGLLMY
MUL_4762|M.ulcerans_Agy99 LAENGVTPAAERREVAIDLRQ--DWPSALRAAGFDPSARTAWLAEGLLMY
MLBr_02640|M.leprae_Br4923 LAEHGVTPTADRREVPIDLRQ--DWPPALRSAGFDPSARTAWLAEGLLMY
MAV_5149|M.avium_104 LAENGVTPSADRREVAVDLRQ--DWPAALRAAGFDPTQRTAWLAEGLLMY
MSMEG_3424|M.smegmatis_MC2_155 LAATGIDIPATATLVPVDFET-QTLASELESASFSRTEPAVFVWLGVIFY
MAB_2253|M.abscessus_ATCC_1997 LTDCGFQIPRWQRLVPVDFEAGACWREQLEIAGFDSGRPAVVASTGVSMY
: * . * *:. * .*. :. *: *
TH_0301|M.thermoresistible__bu LPPDAQDRLLDQITDLSAVGSRLGVEGVPAHADADEDEVRQRMRILAERW
Mvan_1346|M.vanbaalenii_PYR-1 LPPDAQDRLLDTIGELSAPGSRLAVESVPTHHEADQEELREKMKESSDRW
Mflv_5025|M.gilvum_PYR-GCK LPPEAQDALFDTVTALSAPGSTLATEYVPGIVDFDG----AKARALSEPL
MMAR_1068|M.marinum_M LPPDAQDRLFDAISGLSAPGSRLATEYHPDPGSTMA----ERAQQFNQRW
Mb0151|M.bovis_AF2122/97 LPAEAQDRLFTQVGAVSVAGSRIAAETAPVHGEERRAEMRARFKKVADVL
Rv0146|M.tuberculosis_H37Rv LPAEAQDRLFTQVGAVSVAGSRIAAETAPVHGEERRAEMRARFKKVADVL
MUL_4762|M.ulcerans_Agy99 LPAEAQDRLFTQIGELSCAGSRIAAETAGNHADERREQMRERFRKVAQTL
MLBr_02640|M.leprae_Br4923 LPATAQDGLFTEIGGLSAVGSRIAVETSPLHGDEWREQMQLRFRRVSDAL
MAV_5149|M.avium_104 LPAEAQDRLFTLIGELSPAGSRVAAETAPNHADERRQQMRERFKKVADEI
MSMEG_3424|M.smegmatis_MC2_155 LTPDAAGSTLDYIAGQARPVDLVFDYLQP-------AETDEDRADLKN-R
MAB_2253|M.abscessus_ATCC_1997 LTRAAIVATLRQCASLATGSTLAMTFLLPD------ALLNESARTVRQLI
*. * : : :
TH_0301|M.thermoresistible__bu RAHGLDLDFSELIYLGD-RADVAGYLADRGWRCTALTANELLVRTG-LPP
Mvan_1346|M.vanbaalenii_PYR-1 RSHGFDVDFSELVFLGE-RADVTDYLRDRGWTVDATPTNQLLTRYG-LAP
Mflv_5025|M.gilvum_PYR-GCK REHGLDIDMPSLVYTGA-RTPVMDHLRGAGWQVSGTARAELFARFGRPLP
MMAR_1068|M.marinum_M VRLGCDIDLSGLFYEGE-RSNVVDYLTEHGWHVAARPRQDLFTDYGRVFP
Mb0151|M.bovis_AF2122/97 G-IEQTIDVQELVYHDQDRASVADWLTDHGWRARSQRAPDEMRRVGRWVE
Rv0146|M.tuberculosis_H37Rv G-IEQTIDVQELVYHDQDRASVADWLTDHGWRARSQRAPDEMRRVGRWVE
MUL_4762|M.ulcerans_Agy99 G-LEQTIDVHELIYHDPDRAPLGQWLNEHGWRANAQNACDEMHRVGRWVE
MLBr_02640|M.leprae_Br4923 G-FEQAVDVQELIYHDENRAVVADWLNRHGWRATAQSAPDEMRRVGRWGD
MAV_5149|M.avium_104 G-FEQTVDVGELMYRDDHRADVTEWLNAHGWRATAEHSTAAMRRLGRWIE
MSMEG_3424|M.smegmatis_MC2_155 AARLARAGEPLVNYLTS--DELHRQLADFGFRVVEDLSGNEL--IGRYPH
MAB_2253|M.abscessus_ATCC_1997 VARAAAAGTPWLSFFAP--EEMLSLARECGFAQASYVSGREL--IERYVP
. : : : *: :
TH_0301|M.thermoresistible__bu AEND--GRVTEVVYLSSEKSPGKRAG
Mvan_1346|M.vanbaalenii_PYR-1 LDSD--EGFAEVVYVSATR-------
Mflv_5025|M.gilvum_PYR-GCK QDADGTDPLGEIVYVSATLAADA---
MMAR_1068|M.marinum_M -DAD-TSQLRSIVAVTATFGEAG---
Mb0151|M.bovis_AF2122/97 GVPMADDPTAFAEFVTAERL------
Rv0146|M.tuberculosis_H37Rv GVPMADDPTAFAEFVTAERL------
MUL_4762|M.ulcerans_Agy99 GVPMADDKQAYSDFVTAERL------
MLBr_02640|M.leprae_Br4923 GVPMADDKDAFAEFVTAHRL------
MAV_5149|M.avium_104 NVPLADDKDAFSDFVVAERR------
MSMEG_3424|M.smegmatis_MC2_155 GAPVLDERALRASRIVHARC------
MAB_2253|M.abscessus_ATCC_1997 AAGLSAEEFLVATV------------