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TRTDQDSWDLASSVGATATMVAAARALASAEANPIIDDPFAAPLVRAVGLDFFTRLAEGEIDHDEQAQRD RQLVADSIAVRTRFFDDFFLDAARRGVRQSVILAAGLDARAYRLPWPSGSVVYEVDQPDVIDFKDTTMSA LGAVPTATRRTVRVDLRDDWPAALRHNGFDTTQPTAWSAEGLLMYLPPDAQDRLFDAISGLSAPGSRLAT EYHPDPGSTMAERAQQFNQRWVRLGCDIDLSGLFYEGERSNVVDYLTEHGWHVAARPRQDLFTDYGRVFP DADTSQLRSIVAVTATFGEAG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_1068 | - | - | 100% (302) | O-methyltransferase |
| M. marinum M | MMAR_1059 | - | 6e-90 | 61.21% (281) | O-methyltransferase |
| M. marinum M | MMAR_4850 | - | 1e-88 | 55.41% (296) | O-methyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0853 | - | 4e-88 | 57.80% (282) | hypothetical protein Mb0853 |
| M. gilvum PYR-GCK | Mflv_5025 | - | 2e-93 | 59.60% (302) | putative methyltransferase |
| M. tuberculosis H37Rv | Rv0830 | - | 4e-88 | 57.80% (282) | hypothetical protein Rv0830 |
| M. leprae Br4923 | MLBr_02640 | - | 2e-60 | 46.37% (289) | hypothetical protein MLBr_02640 |
| M. abscessus ATCC 19977 | MAB_3787 | - | 9e-83 | 52.92% (308) | hypothetical protein MAB_3787 |
| M. avium 104 | MAV_4435 | - | 1e-125 | 73.27% (303) | methyltransferase, putative, family protein |
| M. smegmatis MC2 155 | MSMEG_1481 | - | 1e-105 | 63.25% (302) | methyltransferase |
| M. thermoresistible (build 8) | TH_2706 | - | 1e-103 | 62.33% (300) | PUTATIVE putative methyltransferase |
| M. ulcerans Agy99 | MUL_0818 | - | 1e-88 | 60.14% (281) | O-methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_1344 | - | 1e-90 | 57.14% (301) | putative methyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0853|M.bovis_AF2122/97 -----MVRADRDRWDLATSVGATATMVAAQRALAADPRYALIDDPYAAPL
Rv0830|M.tuberculosis_H37Rv -----MVRADRDRWDLATSVGATATMVAAQRALAADPRYALIDDPYAAPL
MMAR_1068|M.marinum_M -----MTRTDQDSWDLASSVGATATMVAAARALASAEANPIIDDPFAAPL
MAV_4435|M.avium_104 -----MTRTDQDSWDLASSVGATATMVAAARALASTGERPIINDPFAAPL
MSMEG_1481|M.smegmatis_MC2_155 -----MARTDTDSWDLASSVGATATMVAAARAIASTEPNALIDDPYAADL
TH_2706|M.thermoresistible__bu -----MARSESDTWDLTSGVGVTATMVAAARALASREPEPLIDDPFAAPL
Mflv_5025|M.gilvum_PYR-GCK -----MARTPDDSWDLASSVGATATMVAAGRAVASADPDPLINDPYAEPL
Mvan_1344|M.vanbaalenii_PYR-1 -----MARTADDSWDPASSVGATATMVAAGRAAASADPDPLINDPYAEPL
MAB_3787|M.abscessus_ATCC_1997 -----MARTDDDSWDLASSVGATATMVAAQRALASHVPNPLINDPYAEPL
MUL_0818|M.ulcerans_Agy99 MTSTGSTRYDGDSWDLASSVGVTATMVAAARAMATRAENPLINDPYAEPL
MLBr_02640|M.leprae_Br4923 ------MRTHDDTWDIKTSVGTTAVMVAAARAAETDRPDALIRDPYAKLL
* * ** :.**.**.**** ** : .:* **:* *
Mb0853|M.bovis_AF2122/97 VRAVGMDVYTRLVDWQIPVE---GDSEFD---PQRMATGMACRTRFFDQF
Rv0830|M.tuberculosis_H37Rv VRAVGMDVYTRLVDWQIPVE---GDSEFD---PQRMATGMACRTRFFDQF
MMAR_1068|M.marinum_M VRAVGLDFFTRLAEGEID-----HDEQAQRDRQ-LVADSIAVRTRFFDDF
MAV_4435|M.avium_104 VRAVGLDFFRRLVDGEVAP---ADPQRGERDLQ-LETDSIAVRTRFFDDF
MSMEG_1481|M.smegmatis_MC2_155 VRKVGLEFFTKLVDGDIAL---DGD---DAAAAGLMVSMMAVRTRFFDDF
TH_2706|M.thermoresistible__bu VRAVGVEFFTRLVDGDLEL---PADTAEERAAAQVLTEVMAVRTRFFDDF
Mflv_5025|M.gilvum_PYR-GCK VRAVGLDFFTRMLDGELDLSVFPDSSPE---RAQAMIDGMAVRTRFFDDC
Mvan_1344|M.vanbaalenii_PYR-1 VRAVGLSFFTKMLDGELDLSQFADGSPE---RVQAMIDGMAVRTRFFDDC
MAB_3787|M.abscessus_ATCC_1997 VRAVGIEYFTKLASGAFDPEQMAGLVQLGI-TADGMANGMASRTWYYDTA
MUL_0818|M.ulcerans_Agy99 VRAVGVDLLTRLATGEFNVADLDDDPQRPLGPIGDVADNMAVRTRFFDDF
MLBr_02640|M.leprae_Br4923 VTNTGAGALWEAMLDPSMVAKVEAIDAEAAAMVEHMRSYQAVRTNFFDTY
* .* . * ** ::*
Mb0853|M.bovis_AF2122/97 FLDATHSGIGQFVILASGLDARAYRLAWPVGSIVYEVDMPEVIEFKTATL
Rv0830|M.tuberculosis_H37Rv FLDATHSGIGQFVILASGLDARAYRLAWPVGSIVYEVDMPEVIEFKTATL
MMAR_1068|M.marinum_M FLDAARRGVRQSVILAAGLDARAYRLPWPSGSVVYEVDQPDVIDFKDTTM
MAV_4435|M.avium_104 FTGAARDGIRQSVILAAGLDARAYRLDWPAGAVVYEVDQPKVVEFKTNTM
MSMEG_1481|M.smegmatis_MC2_155 FCDAAGAGIRQSVILAAGLDSRAYRLGWPAGTVVYEIDQPRVIEAKTAAM
TH_2706|M.thermoresistible__bu FTDATRVGARQAVILASGLDARAYRLTWPDGTVVYEIDQPEVIAFKTRTL
Mflv_5025|M.gilvum_PYR-GCK CLAAASAGVRQVVILAAGLDARTYRLPWPDGTVVYELDQPDVIAFKTQTL
Mvan_1344|M.vanbaalenii_PYR-1 CGTSTTAGITQVVILASGLDARAYRLGWPAGTVVYELDQPAVIEFKTRTL
MAB_3787|M.abscessus_ATCC_1997 FESSTAAGVRQAVILASGLDTRAYRLTWPAGTTVYELDQPEVITFKTDTL
MUL_0818|M.ulcerans_Agy99 FLAATRAGLEQVVILASGRDARAYRLPWPPQTVVYEIDLPQVIDFKSRTL
MLBr_02640|M.leprae_Br4923 FNNAVIDGIRQFVILASGLDSRAYRLDWPTGTTVYEIDQPKVLAYKSTTL
:. * * ****:* *:*:*** ** : ***:* * *: * ::
Mb0853|M.bovis_AF2122/97 SDLGAEPATERRTVAVDLRDDWATALQTAGFDPKVPAAWSAEGLLVYLPV
Rv0830|M.tuberculosis_H37Rv SDLGAEPATERRTVAVDLRDDWATALQTAGFDPKVPAAWSAEGLLVYLPV
MMAR_1068|M.marinum_M SALGAVPTATRRTVRVDLRDDWPAALRHNGFDTTQPTAWSAEGLLMYLPP
MAV_4435|M.avium_104 AALDARPAAQLRTVSIDLREDWPEALRANGFDVTQATSWSAEGLLMYLPP
MSMEG_1481|M.smegmatis_MC2_155 AEIGASPTAERRTVAVDLRDDWPAALRAAGFDAATPTAWIAEGLLVYLPP
TH_2706|M.thermoresistible__bu AELGAPPTAPHRPVAVDLRDDWPAALTAAGFDPTVATAWSAEGLLRYLPP
Mflv_5025|M.gilvum_PYR-GCK RNLGAEPAATQRPVPVDLREDWPAALRAAGFDATRPTAWLAEGLLIYLPP
Mvan_1344|M.vanbaalenii_PYR-1 AGLGAHPTATHRPVPIDLREDWPAALHAAGFDASRPTAWLAEGLLIYLPP
MAB_3787|M.abscessus_ATCC_1997 AELGASPSAERRTVAIDLREDWPAALQAAGFDPEQPTVWSAEGLLIYLPP
MUL_0818|M.ulcerans_Agy99 ADLGAAPTADRRVVAVDLREDWPAALRAAGFDPNQPTAWSAEGLLGYLPP
MLBr_02640|M.leprae_Br4923 AEHGVTPTADRREVPIDLRQDWPPALRSAGFDPSARTAWLAEGLLMYLPA
.. *:: * * :***:**. ** *** : * ***** ***
Mb0853|M.bovis_AF2122/97 EAQDALFDNITALSAPGSRLAFEFVPDTAIFADE----RWRNYHNRMSEL
Rv0830|M.tuberculosis_H37Rv EAQDALFDNITALSAPGSRLAFEFVPDTAIFADE----RWRNYHNRMSEL
MMAR_1068|M.marinum_M DAQDRLFDAISGLSAPGSRLATEYHPDP-GSTMA---ERAQQFNQRWVRL
MAV_4435|M.avium_104 EAQDRLFDNITALSAPGSRLATEYHPDATGTTMA---QRAQEFNDRWARV
MSMEG_1481|M.smegmatis_MC2_155 EAQDRLFDNITALSARGSRLATEYHPDI-TSTLR---GRGQAMSERWRDH
TH_2706|M.thermoresistible__bu DAQDRLFDHITDLSAPGSRLATEDHPGP-GAGLG---EKADELGRRWREH
Mflv_5025|M.gilvum_PYR-GCK EAQDALFDTVTALSAPGSTLATEYVPGIVDFDGA----KARALSEPLREH
Mvan_1344|M.vanbaalenii_PYR-1 EAQDQLFDRITALSAPGSTIATEYAPGIIDFDDE----KARAMSAPMREM
MAB_3787|M.abscessus_ATCC_1997 EAQDRLFASITELSAPGSRLVCEQVPGLETADFS----KARELTRQFAGE
MUL_0818|M.ulcerans_Agy99 EAQDRLLDTVTELSAPGSRLAAECLSGVDPAEEEQIKERMQEVSARWRAH
MLBr_02640|M.leprae_Br4923 TAQDGLFTEIGGLSAVGSRIAVETSPLHGDEWREQMQLRFRRVSDALG-F
*** *: : *** ** :. * . :
Mb0853|M.bovis_AF2122/97 GFDIDLNELVYHGQ-RGHVLDYLTRDGWQTSALTVTQLYEANGFAYPDDE
Rv0830|M.tuberculosis_H37Rv GFDIDLNELVYHGQ-RGHVLDYLTRDGWQTSALTVTQLYEANGFAYPDDE
MMAR_1068|M.marinum_M GCDIDLSGLFYEGE-RSNVVDYLTEHGWHVAARPRQDLFTDYGRVFP-DA
MAV_4435|M.avium_104 GCDIDLSGLFFDGE-RSNVVEYLTGRGWRVSARPRRDLFDDYGLAYPEDD
MSMEG_1481|M.smegmatis_MC2_155 GFDVDLSDLWYGGD-RNAADEYLAGHGWQVSTRPRPEVFAAYGRTFPDLT
TH_2706|M.thermoresistible__bu GFEVQLSELFHPGE-RTPVVDYLRGRGWDARARPRAEVFAGYGREFPDSA
Mflv_5025|M.gilvum_PYR-GCK GLDIDMPSLVYTGA-RTPVMDHLRGAGWQVSGTARAELFARFGRPLPQDA
Mvan_1344|M.vanbaalenii_PYR-1 GLDIDMPSLVYAGT-RSHVMDYLAGQGWEVTGVPRRELFTRYGRPLPPEA
MAB_3787|M.abscessus_ATCC_1997 TLDLDLESLVYTQE-RQMAADWLAEHGWTVITEENDELYARLN-LDPPNP
MUL_0818|M.ulcerans_Agy99 GFDVDMVGLVYFGD-RNEAVPYLSDRGWLLTSTPLPELRAANG-LAPAAV
MLBr_02640|M.leprae_Br4923 EQAVDVQELIYHDENRAVVADWLNRHGWRATAQSAPDEMRRVGRWGDGVP
::: * . * . * ** : .
Mb0853|M.bovis_AF2122/97 LA----TAFADLTYSSATLMR--------
Rv0830|M.tuberculosis_H37Rv LA----TAFADLTYSSATLMR--------
MMAR_1068|M.marinum_M DT----SQLRSIVAVTATFGEAG------
MAV_4435|M.avium_104 ET----AQFPNIVAVSAELG---------
MSMEG_1481|M.smegmatis_MC2_155 LTGDDNAAMRQSVAITATRS---------
TH_2706|M.thermoresistible__bu AL----AAMRDSSAVTAVRPVVRAGMR--
Mflv_5025|M.gilvum_PYR-GCK DG---TDPLGEIVYVSATLAADA------
Mvan_1344|M.vanbaalenii_PYR-1 GD---TDPLGEIVYVSAHRPQ--------
MAB_3787|M.abscessus_ATCC_1997 LL---RSIFPNIVYVDATLG---------
MUL_0818|M.ulcerans_Agy99 DD---DGPSVDMLYVSGTLYTTPRPDPAP
MLBr_02640|M.leprae_Br4923 MAD---DKDAFAEFVTAHRL---------
.