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RTHDDTWDIRTSVGATAVMVAAARAVETSKPEPLIRDPYARMLVTNANAGVIWEAMLDQEMVAKVEAIDA ETAATVEHMRSYQAVRTNFFDTYFADAVAAGIRQVVILASGLDSRAYRLDWPAGTTVYEIDQPQVLAYKS ATLAENGVTPAAERREVAIDLRQDWPSALRAAGFDPSARTAWLAEGLLMYLPAEAQDRLFTQIGELSCAG SRIAAETAGNHADERREQMRERFRKVAQTLGLEQTIDVHELIYHDPDRAPLGQWLNEHGWRANAQNACDE MHRVGRWVEGVPMADDKQAYSDFVTAERL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_4762 | - | - | 100% (310) | O-methyltransferase |
| M. ulcerans Agy99 | MUL_4402 | - | 1e-70 | 48.18% (303) | O-methyltransferase |
| M. ulcerans Agy99 | MUL_0706 | - | 4e-67 | 44.73% (313) | hypothetical protein MUL_0706 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0151 | - | 1e-144 | 80.00% (310) | hypothetical protein Mb0151 |
| M. gilvum PYR-GCK | Mflv_0743 | - | 1e-104 | 61.74% (311) | putative methyltransferase |
| M. tuberculosis H37Rv | Rv0146 | - | 1e-144 | 80.00% (310) | hypothetical protein Rv0146 |
| M. leprae Br4923 | MLBr_02640 | - | 1e-138 | 77.10% (310) | hypothetical protein MLBr_02640 |
| M. abscessus ATCC 19977 | MAB_4607c | - | 3e-80 | 53.11% (305) | hypothetical protein MAB_4607c |
| M. marinum M | MMAR_0357 | - | 1e-178 | 99.35% (310) | O-methyltransferase |
| M. avium 104 | MAV_5149 | - | 1e-143 | 77.67% (309) | methyltransferase, putative, family protein |
| M. smegmatis MC2 155 | MSMEG_0095 | - | 1e-113 | 65.48% (310) | methyltransferase |
| M. thermoresistible (build 8) | TH_4502 | - | 1e-111 | 64.04% (317) | PUTATIVE methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_0104 | - | 1e-105 | 63.96% (308) | putative methyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_4762|M.ulcerans_Agy99 ---MRTHDDTWDIRTSVGATAVMVAAARAVETSKPEPLIRDPYARMLVTN
MMAR_0357|M.marinum_M MSTMRTHDDTWDIRTSVGATAVMVAAARAVETSKPEPLIRDPYARMLVTN
Mb0151|M.bovis_AF2122/97 ---MRTHDDTWDIKTSVGATAVMVAAARAVETDRPDPLIRDPYARLLVTN
Rv0146|M.tuberculosis_H37Rv ---MRTHDDTWDIKTSVGATAVMVAAARAVETDRPDPLIRDPYARLLVTN
MLBr_02640|M.leprae_Br4923 ---MRTHDDTWDIKTSVGTTAVMVAAARAAETDRPDALIRDPYAKLLVTN
MAV_5149|M.avium_104 MSSLRTHDDTWDIKSSVGTTAVMVAAARAVETEQPDPLIRDPYAKLLVTN
MSMEG_0095|M.smegmatis_MC2_155 MSSLRTDDDTWDIATSVGSTAVMVAAARAGETERDDALIRDPYAKILVAG
TH_4502|M.thermoresistible__bu MSSLRTDDDTWDIATSVGSTAVMVAASRAAETEREDALIRDPYAKVLVAG
Mflv_0743|M.gilvum_PYR-GCK MSSLRTDDDTWDIASSVGATAVMVAAARAAETERHDALINDPYAKVLVEG
Mvan_0104|M.vanbaalenii_PYR-1 MSSLRTDNDTWDIASSVGATAVMVAAARAAETERPEPLIDDPYAKILVAG
MAB_4607c|M.abscessus_ATCC_199 ---MRVDGDTWDITSSVGATALGVAAARATETLRADALIRDPFAQILVDA
:*...***** :***:**: ***:** ** : :.** **:*::**
MUL_4762|M.ulcerans_Agy99 ANAGVIWEAMLDQEMVAKVEAIDAETAATVEHMRSYQAVRTNFFDTYFAD
MMAR_0357|M.marinum_M ANAGVIWEAMLDQEMVAKVEAIDAETAATVEHMRSYQAVRTNFFDTYFAD
Mb0151|M.bovis_AF2122/97 AGAGAIWEAMLDPTLVAKAAAIDAETAAIVAYLRSYQAVRTNFFDTYFAS
Rv0146|M.tuberculosis_H37Rv AGAGAIWEAMLDPTLVAKAAAIDAETAAIVAYLRSYQAVRTNFFDTYFAS
MLBr_02640|M.leprae_Br4923 TGAGALWEAMLDPSMVAKVEAIDAEAAAMVEHMRSYQAVRTNFFDTYFNN
MAV_5149|M.avium_104 SGAGVLWEAMLDPDIAARVEALDEESAAHLHHMRGYQAVRTHFFDTYFAD
MSMEG_0095|M.smegmatis_MC2_155 AGTG-VWETVLDSEFAAKIENLDPEAAAIFAHMGNYQAVRTHFFDAYYRE
TH_4502|M.thermoresistible__bu AGTG-VWELILDDDFTAKIEAADPETAAIFDHMGNYQAVRTHFFDTYFAR
Mflv_0743|M.gilvum_PYR-GCK AGAG-AWRFIADEDLVAKASESDTEVGALFEHMKNYQAVRTHFFDAFFSA
Mvan_0104|M.vanbaalenii_PYR-1 AGNG-AWQYIADDGFVAKVTESDPEIGPLFEHMKNYQAVRTHFFDAFFAA
MAB_4607c|M.abscessus_ATCC_199 TGKATGWERLVAG----DIDWPDPEAGRIYDRMVDYQATRTHFFDEYFLA
:. . *. : * * . : .***.**:*** ::
MUL_4762|M.ulcerans_Agy99 AVAAGIRQVVILASGLDSRAYRLDWPAGTTVYEIDQPQVLAYKSATLAEN
MMAR_0357|M.marinum_M AVAAGIRQVVILASGLDSRAYRLDWPAGTTVYEIDQPQVLAYKSATLAEN
Mb0151|M.bovis_AF2122/97 AVAAGIRQVVILASGLDSRAYRLDWPAGTIVYEIDQPKVLSYKSTTLAEN
Rv0146|M.tuberculosis_H37Rv AVAAGIRQVVILASGLDSRAYRLDWPAGTIVYEIDQPKVLSYKSTTLAEN
MLBr_02640|M.leprae_Br4923 AVIDGIRQFVILASGLDSRAYRLDWPTGTTVYEIDQPKVLAYKSTTLAEH
MAV_5149|M.avium_104 AVAAGIRQIVILASGLDSRAYRLDWPAGTTVYEIDQPQVLAYKSTTLAEN
MSMEG_0095|M.smegmatis_MC2_155 AADAGIRQIVILASGLDSRAYRLDWPAGTTVYEIDQPKVLEYKSATLREH
TH_4502|M.thermoresistible__bu AAEAGIRQVVILASGLDSRAYRLPWPDGTVVYEIDQPKVLEYKSATLAAH
Mflv_0743|M.gilvum_PYR-GCK AVDAGVRQIVILASGLDSRAFRLPWPAGTVVYEIDQPLVLDYKSSTLAAH
Mvan_0104|M.vanbaalenii_PYR-1 AVDAGIRQIVILASGLDSRAFRLPWPAGTTVFEIDQPLVLAYKSSTLASH
MAB_4607c|M.abscessus_ATCC_199 AAAAGIRQVVILASGLDSRAYRLDWPAGTTVYEIDQPQVLKFKDSALAAH
*. *:**.***********:** ** ** *:***** ** :*.::* :
MUL_4762|M.ulcerans_Agy99 GVTPAAERREVAIDLRQDWPSALRAAGFDPSARTAWLAEGLLMYLPAEAQ
MMAR_0357|M.marinum_M GVTPAAERREVAIDLRQDWPSALRAAGFDPSARTAWLAEGLLMYLPAEAQ
Mb0151|M.bovis_AF2122/97 GVTPSAGRREVPADLRQDWPAALRDAGFDPTARTAWLAEGLLMYLPAEAQ
Rv0146|M.tuberculosis_H37Rv GVTPSAGRREVPADLRQDWPAALRDAGFDPTARTAWLAEGLLMYLPAEAQ
MLBr_02640|M.leprae_Br4923 GVTPTADRREVPIDLRQDWPPALRSAGFDPSARTAWLAEGLLMYLPATAQ
MAV_5149|M.avium_104 GVTPSADRREVAVDLRQDWPAALRAAGFDPTQRTAWLAEGLLMYLPAEAQ
MSMEG_0095|M.smegmatis_MC2_155 GIEPVAQRREVPVDLRFDWPTALHDAGFDASLPTAWLAEGLLMYLPAEAQ
TH_4502|M.thermoresistible__bu GVQPAADRREVAVDLRHDWPKALRAKGFDPQQRTAWLAEGLLMYLPADAQ
Mflv_0743|M.gilvum_PYR-GCK GVAPTAERREVPIDLRQDWPAALVATGFDPARPTAWLAEGLLMYLPADAQ
Mvan_0104|M.vanbaalenii_PYR-1 GVQPTADRREVPIDLRQDWPTALTHAGFDADQPTAWLAEGLLMYLPADAQ
MAB_4607c|M.abscessus_ATCC_199 --QPTAQRRGVAIDLREDWPAALRAAGFDSAQPTAWLAEGLLPYLPADAQ
* * ** *. *** *** ** ***. ********* **** **
MUL_4762|M.ulcerans_Agy99 DRLFTQIGELSCAGSRIAAETAG---NHADERREQMRERFRKVAQTLGLE
MMAR_0357|M.marinum_M DRLFTQIGELSCAGSRIAAETAG---NHADERREQMRERFRKVAQTLGLE
Mb0151|M.bovis_AF2122/97 DRLFTQVGAVSVAGSRIAAETAP---VHGEERRAEMRARFKKVADVLGIE
Rv0146|M.tuberculosis_H37Rv DRLFTQVGAVSVAGSRIAAETAP---VHGEERRAEMRARFKKVADVLGIE
MLBr_02640|M.leprae_Br4923 DGLFTEIGGLSAVGSRIAVETSP---LHGDEWREQMQLRFRRVSDALGFE
MAV_5149|M.avium_104 DRLFTLIGELSPAGSRVAAETAP---NHADERRQQMRERFKKVADEIGFE
MSMEG_0095|M.smegmatis_MC2_155 DRLFELVTELSAPGSRIAVETAG---VAATDRREAMRERFKKFADQLNLS
TH_4502|M.thermoresistible__bu DRLFENITALSAPGSRLAVETAA---EEPVDRREQMRARMERIASQFGLE
Mflv_0743|M.gilvum_PYR-GCK DRLFAQITELSAPGSQVAAESMG---VHAPDRRERMRERFASIASQIDIE
Mvan_0104|M.vanbaalenii_PYR-1 DRLFAQITELSAPGSRVAAESMG---IHAQDRRERMRERFASITAQFDVE
MAB_4607c|M.abscessus_ATCC_199 DNLFRDIGVLSAAGSRVAVEGYEGKLVLDESEEEAVRREQVRAAFKTAID
* ** : :* **::*.* . . :: . : ..
MUL_4762|M.ulcerans_Agy99 QTIDVHELIYHDPDRAPLGQWLNEHGWRANAQNACDEMHRVGRWVEGVPM
MMAR_0357|M.marinum_M QTIDVHELIYHDPDRALLGQWLNEHGWRANAQNACDEMHRVGRWVEGVPM
Mb0151|M.bovis_AF2122/97 QTIDVQELVYHDQDRASVADWLTDHGWRARSQRAPDEMRRVGRWVEGVPM
Rv0146|M.tuberculosis_H37Rv QTIDVQELVYHDQDRASVADWLTDHGWRARSQRAPDEMRRVGRWVEGVPM
MLBr_02640|M.leprae_Br4923 QAVDVQELIYHDENRAVVADWLNRHGWRATAQSAPDEMRRVGRWGDGVPM
MAV_5149|M.avium_104 QTVDVGELMYRDDHRADVTEWLNAHGWRATAEHSTAAMRRLGRWIENVPL
MSMEG_0095|M.smegmatis_MC2_155 SALDIQELVYDDPDRADVAEWLDAHGWRARGVHALDEMRRLDRLVELPDD
TH_4502|M.thermoresistible__bu KALDVAQLMYDDPDRADVPEWLTGHGWRTEWVSAPDEMRRLDRFVAAAMP
Mflv_0743|M.gilvum_PYR-GCK P-MDITELTYEDPDRAEVAEWLAAHGWTAQAVPSQDAMRRLDRYVEVADS
Mvan_0104|M.vanbaalenii_PYR-1 P-MDITELTYEDPDRADVAQWLTAHGWRAEAVPSQDEMRRLHRLVEIADG
MAB_4607c|M.abscessus_ATCC_199 VDVTIENLIYEDENRADPAEWLDAHGWSVTKTDAHDEMARLGRPVAEDVE
: : :* * * .** :** *** . : * *: *
MUL_4762|M.ulcerans_Agy99 AD--------DKQAYSDFVTAERL-
MMAR_0357|M.marinum_M AD--------DKQAYSEFVTAERL-
Mb0151|M.bovis_AF2122/97 AD--------DPTAFAEFVTAERL-
Rv0146|M.tuberculosis_H37Rv AD--------DPTAFAEFVTAERL-
MLBr_02640|M.leprae_Br4923 AD--------DKDAFAEFVTAHRL-
MAV_5149|M.avium_104 AD--------DKDAFSDFVVAERR-
MSMEG_0095|M.smegmatis_MC2_155 P---------DRAAFSTFVTAQRL-
TH_4502|M.thermoresistible__bu PGDDADAADLDDTAFSKFVTAERPS
Mflv_0743|M.gilvum_PYR-GCK D----------GQSFSTFTTGTKL-
Mvan_0104|M.vanbaalenii_PYR-1 D----------DQSFSTFTTAVKR-
MAB_4607c|M.abscessus_ATCC_199 RG----------TFRGQLIQGELR-
. : .