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M. thermoresistible (build 8) TH_0301 ()

annotation: CONSERVED HYPOTHETICAL PROTEIN
coordinates: 673957 - 674820
length: 288

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_0301-100% (288)CONSERVED HYPOTHETICAL PROTEIN
M. thermoresistible (build 8)TH_2706-5e-7958.98% (256) PUTATIVE putative methyltransferase
M. thermoresistible (build 8)TH_4502-5e-6048.50% (266) PUTATIVE methyltransferase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0752c-6e-8557.61% (276) hypothetical protein Mb0752c
M. gilvum PYR-GCKMflv_5023-8e-9259.14% (279) putative methyltransferase
M. tuberculosis H37RvRv0731c-6e-8557.61% (276) hypothetical protein Rv0731c
M. leprae Br4923MLBr_02640-4e-5646.32% (285) hypothetical protein MLBr_02640
M. abscessus ATCC 19977MAB_3787-8e-7054.51% (266) hypothetical protein MAB_3787
M. marinum MMMAR_1059-4e-8657.91% (278) O-methyltransferase
M. avium 104MAV_4441-1e-8757.19% (278) methyltransferase, putative, family protein
M. smegmatis MC2 155MSMEG_1482-3e-9559.42% (276) methyltransferase
M. ulcerans Agy99MUL_0818-3e-8657.91% (278) O-methyltransferase
M. vanbaalenii PYR-1Mvan_1346-1e-9259.22% (282) putative methyltransferase

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_5023|M.gilvum_PYR-GCK          -----MPRTENDTWDLASSVGATATMVAAARAVATRAEDPVIDDPYAEPL
Mvan_1346|M.vanbaalenii_PYR-1       -----MARTDNDTWDLASSVGATATMVAAARAVATRAPRPVIDDPFAAPL
MSMEG_1482|M.smegmatis_MC2_155      -----MARTENDTWDLASSVGATATMVAAARALATNADEPAIDDPFAAPL
TH_0301|M.thermoresistible__bu      -----MX-------------GG-----------ASRDPKELINDPFAAPL
Mb0752c|M.bovis_AF2122/97           MTQTGSARFEGDSWDLASSVGLTATMVAAARAVAGRAPGALVNDQFAEPL
Rv0731c|M.tuberculosis_H37Rv        MTQTGSARFEGDSWDLASSVGLTATMVAAARAVAGRAPGALVNDQFAEPL
MMAR_1059|M.marinum_M               MTSTGSTRYDGDSWDLASSVGVTATMVAAARAMATRAENPLINDPYAEPL
MUL_0818|M.ulcerans_Agy99           MTSTGSTRYDGDSWDLASSVGVTATMVAAARAMATRAENPLINDPYAEPL
MAV_4441|M.avium_104                MTST---RYEGDTWDLASSVGVTATMVAAARAMATRADNPLINDPFAEPL
MAB_3787|M.abscessus_ATCC_1997      -----MARTDDDSWDLASSVGATATMVAAQRALASHVPNPLINDPYAEPL
MLBr_02640|M.leprae_Br4923          ------MRTHDDTWDIKTSVGTTAVMVAAARAAETDRPDALIRDPYAKLL
                                                        *                    : * :*  *

Mflv_5023|M.gilvum_PYR-GCK          VRAVGIDFFAKLASGELTPEDLDVS---GDESPVGMSRFADGMAARTRFF
Mvan_1346|M.vanbaalenii_PYR-1       VQAVGVDFFTRLATGELTTEELDTN---DAESPVGMSRFADAMAARTRFF
MSMEG_1482|M.smegmatis_MC2_155      VRAVGVDFFTKLVDDNFDLTALDP------EAAEGLTRFANGMAARTRFF
TH_0301|M.thermoresistible__bu      VRAVGIDFFTRIADGELTVADLDP------QSAPRVQANIDEVAVRTRFF
Mb0752c|M.bovis_AF2122/97           VRAVGVDFFVRMASGELDPDELA------EDEANGLRRFADAMAIRTHYF
Rv0731c|M.tuberculosis_H37Rv        VRAVGVDFFVRMASGELDPDELA------EDEANGLRRFADAMAIRTHYF
MMAR_1059|M.marinum_M               VRAVGVDLLTRLATGEFNVADLD---DDPQRPLGPLGDVADNMAVRTRFF
MUL_0818|M.ulcerans_Agy99           VRAVGVDLLTRLATGEFNVADLD---DDPQRPLGPIGDVADNMAVRTRFF
MAV_4441|M.avium_104                VKAVGVDLLSRLAGGELDPAELNDVHDGAAGSAGAMSRMADNMAVRTKFF
MAB_3787|M.abscessus_ATCC_1997      VRAVGIEYFTKLASGAFDPEQMAG----LVQLGITADGMANGMASRTWYY
MLBr_02640|M.leprae_Br4923          VTNTGAGALWEAMLDPSMVAKVEAI---DAEAAAMVEHMRSYQAVRTNFF
                                    *  .*   : .   .      :                  .  * ** ::

Mflv_5023|M.gilvum_PYR-GCK          DDFFTDACAAG---VRQAVILASGLDARGYRLTWPEGMTLFEIDQPEVIE
Mvan_1346|M.vanbaalenii_PYR-1       DDFFAEAMRAGPPPIRQGVILASGLDARAYRLSWPQDMVLFEIDQPEVLT
MSMEG_1482|M.smegmatis_MC2_155      DDFFLDAARAG---VRQFVILASGLDARAYRLPWPAGSVVFEIDQPDVIE
TH_0301|M.thermoresistible__bu      DDHFAAATARG---IRQAVILAAGLDARAYRLRWPDGTVVYEIDQPRVIE
Mb0752c|M.bovis_AF2122/97           DNFFLDATRAG---IRQAVILASGLDSRAYRLRWPAGTIVFEVDQPQVID
Rv0731c|M.tuberculosis_H37Rv        DNFFLDATRAG---IRQAVILASGLDSRAYRLRWPAGTIVFEVDQPQVID
MMAR_1059|M.marinum_M               DDFFLDATRAG---LEQVVILASGLDARAYRLPWPPQTVVYEIDLPQVIE
MUL_0818|M.ulcerans_Agy99           DDFFLAATRAG---LEQVVILASGRDARAYRLPWPPQTVVYEIDLPQVID
MAV_4441|M.avium_104                DEFFLNATKAG---IAQVVILASGLDARAYRLAWPAGTVVYEVDQPQVID
MAB_3787|M.abscessus_ATCC_1997      DTAFESSTAAG---VRQAVILASGLDTRAYRLTWPAGTTVYELDQPEVIT
MLBr_02640|M.leprae_Br4923          DTYFNNAVIDG---IRQFVILASGLDSRAYRLDWPTGTTVYEIDQPKVLA
                                    *  *  :   *   : * ****:* *:*.*** **    ::*:* * *: 

Mflv_5023|M.gilvum_PYR-GCK          FKRTTLAGLGATPSTHLATVAIDLREDWPTALRDAGFDPSVPTAWIAEGL
Mvan_1346|M.vanbaalenii_PYR-1       FKAATLADLGVRPSTKLATVAVDLRNDWPAALAEAGFDASAPTAWIAEGL
MSMEG_1482|M.smegmatis_MC2_155      FKTKALADLGALPTTDRRAVAVDLRFDWPAALTEAGFDPAEPTAWIAEGL
TH_0301|M.thermoresistible__bu      FKTRTLARLGAEPTAERRTVAADLRHDWPAALTAAGFDPAAPTVWIAEGL
Mb0752c|M.bovis_AF2122/97           FKTTTLAGLGAAPTTDRRTVAVDLRDDWPTALQKAGFDNAQRTAWIAEGL
Rv0731c|M.tuberculosis_H37Rv        FKTTTLAGLGAAPTTDRRTVAVDLRDDWPTALQKAGFDNAQRTAWIAEGL
MMAR_1059|M.marinum_M               FKSRTLADLGAAPTADRRVVAVDLREDWPAALRAAGFDPNQPTAWSAEGL
MUL_0818|M.ulcerans_Agy99           FKSRTLADLGAAPTADRRVVAVDLREDWPAALRAAGFDPNQPTAWSAEGL
MAV_4441|M.avium_104                FKTTALAQLGAAPTAERRVVAVDLRDDWPAALRAAGFDPTRPTAWSAEGL
MAB_3787|M.abscessus_ATCC_1997      FKTDTLAELGASPSAERRTVAIDLREDWPAALQAAGFDPEQPTVWSAEGL
MLBr_02640|M.leprae_Br4923          YKSTTLAEHGVTPTADRREVPIDLRQDWPPALRSAGFDPSARTAWLAEGL
                                    :*  :**  *. *::.   *. *** ***.**  ****    *.* ****

Mflv_5023|M.gilvum_PYR-GCK          LGYLPPDAQDRLLDTIGELSASGSRLAVESVPSQQSADQDEMREKMKDST
Mvan_1346|M.vanbaalenii_PYR-1       LGYLPPDAQDRLLDTIGELSAPGSRLAVESVPTHHEADQEELREKMKESS
MSMEG_1482|M.smegmatis_MC2_155      LGYLPPEAQDRLLDQIAELSAPGSRVAVEEIPAIEEEDHEEIAARMKDFS
TH_0301|M.thermoresistible__bu      FGYLPPDAQDRLLDQITDLSAVGSRLGVEGVPAHADADEDEVRQRMRILA
Mb0752c|M.bovis_AF2122/97           LGYLSAEAQDRLLDQITAQSVPGSQFATEVLRDINRLNEEELRGRMRRLA
Rv0731c|M.tuberculosis_H37Rv        LGYLSAEAQDRLLDQITAQSVPGSQFATEVLRDINRLNEEELRGRMRRLA
MMAR_1059|M.marinum_M               LGYLPPEAQDRLLDTVTELSAPGSRLAAECLSSVDPGEEEQIKERMQEVS
MUL_0818|M.ulcerans_Agy99           LGYLPPEAQDRLLDTVTELSAPGSRLAAECLSGVDPAEEEQIKERMQEVS
MAV_4441|M.avium_104                LGYLPPEAQDRLLDTITELSAPGSRLATESAPNPAPGEEEKLKERMQAIS
MAB_3787|M.abscessus_ATCC_1997      LIYLPPEAQDRLFASITELSAPGSRLVCEQVPGLETADFS----KARELT
MLBr_02640|M.leprae_Br4923          LMYLPATAQDGLFTEIGGLSAVGSRIAVETSPLHGDEWREQMQLRFRRVS
                                    : **.. *** *:  :   *. **:.  *          .    : :  :

Mflv_5023|M.gilvum_PYR-GCK          DRWRSHGFDLDFSELVFLGE-RANVPDYLRERGWAVTATPTNDLLTRYG-
Mvan_1346|M.vanbaalenii_PYR-1       DRWRSHGFDVDFSELVFLGE-RADVTDYLRDRGWTVDATPTNQLLTRYG-
MSMEG_1482|M.smegmatis_MC2_155      DRWRAHGFDLDFTELVFLGD-RADVSSYLQGHGWKTTSMTSDELLVHNG-
TH_0301|M.thermoresistible__bu      ERWRAHGLDLDFSELIYLGD-RADVAGYLADRGWRCTALTANELLVRTG-
Mb0752c|M.bovis_AF2122/97           ERFRRHGLDLDMSGLVYFGD-RTDARTYLADHGWRTASASTTDLLAEHG-
Rv0731c|M.tuberculosis_H37Rv        ERFRRHGLDLDMSGLVYFGD-RTDARTYLADHGWRTASASTTDLLAEHG-
MMAR_1059|M.marinum_M               ARWRAHGFDVDMVGLVYFGD-RNEAVPYLSDRGWLLTSTPLPELRAANG-
MUL_0818|M.ulcerans_Agy99           ARWRAHGFDVDMVGLVYFGD-RNEAVPYLSDRGWLLTSTPLPELRAANG-
MAV_4441|M.avium_104                QRWRAHGFDLDMAGLVYFGE-RNEAAPYLAGHGWRLNSVTIRDLFAANG-
MAB_3787|M.abscessus_ATCC_1997      RQFAGETLDLDLESLVYTQE-RQMAADWLAEHGWTVITEENDELYARLN-
MLBr_02640|M.leprae_Br4923          DALG-FEQAVDVQELIYHDENRAVVADWLNRHGWRATAQSAPDEMRRVGR
                                             :*.  *::  : *  .  :*  :**   :    :     . 

Mflv_5023|M.gilvum_PYR-GCK          LAPLD--TDEGFAEVVYVNAAR----------
Mvan_1346|M.vanbaalenii_PYR-1       LAPLD--SDEGFAEVVYVSATR----------
MSMEG_1482|M.smegmatis_MC2_155      LPRVD--DDAQIGSVVYVTATR----------
TH_0301|M.thermoresistible__bu      LPPAE--NDGRVTEVVYLSSEKSPGKRAG---
Mb0752c|M.bovis_AF2122/97           LPPID-GDDAPFGEVIYVSAELKQKHQDTR--
Rv0731c|M.tuberculosis_H37Rv        LPPID-GDDAPFGEVIYVSAELKQKHQDTR--
MMAR_1059|M.marinum_M               LAPAAVDDDGPSVDMLYVSGTLYTTPRPDPAP
MUL_0818|M.ulcerans_Agy99           LAPAAVDDDGPSVDMLYVSGTLYTTPRPDPAP
MAV_4441|M.avium_104                LDPLD-DDDTRMGEMLYTWG-IYE--------
MAB_3787|M.abscessus_ATCC_1997      LDPPNPLLRSIFPNIVYVDATLG---------
MLBr_02640|M.leprae_Br4923          WGDGVPMADDKDAFAEFVTAHRL---------
                                                    :  .