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MTTLESMVDRDLQSLIDSVLANHDCRDDRKLWQTLGELGLADLTQSEDRGGSGACWPEAAALARALARRG CRLEVSESDLVAGWLLERAAAPPRQALRVVLFDDEHTTVPTASGLVERVAVVGHDGEEYHVSDVPVTDIG GDRDGDLHRDEDRRDRHLITRETFELARTRRSLVRAIQISATLETIAELAIEYAQTREQFGRPIGKQQAV QQMIAIIAGESALARAATDAAVLAVSDDATPASQVAAMVAVARSCCGHAVDPVVRNAHQVIGAIGTTREH RLHVFTSAALALRAQDRTTREWDAAVLDLTIQAQPLSDLDLMPVRTR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3393 | - | - | 100% (327) | putative acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2878 | - | 3e-58 | 43.12% (320) | putative acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_6041 | - | 5e-16 | 28.93% (318) | putative acyl-CoA dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0277c | fadE6 | 7e-13 | 26.67% (330) | acyl-CoA dehydrogenase FADE6 |
| M. gilvum PYR-GCK | Mflv_5167 | - | 8e-54 | 41.23% (325) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv0271c | fadE6 | 7e-13 | 26.67% (330) | acyl-CoA dehydrogenase FADE6 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0594c | - | 5e-13 | 28.37% (282) | acyl-CoA dehydrogenase FadE |
| M. marinum M | MMAR_3512 | - | 2e-56 | 42.51% (334) | acyl-CoA dehydrogenase |
| M. avium 104 | MAV_2553 | - | 1e-26 | 31.48% (305) | acyl-CoA dehydrogenase, C- |
| M. thermoresistible (build 8) | TH_4629 | - | 1e-24 | 31.31% (313) | PUTATIVE putative acyl-CoA dehydrogenase |
| M. ulcerans Agy99 | MUL_2756 | - | 1e-54 | 41.62% (334) | acyl-CoA dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_3918 | - | 7e-59 | 43.89% (319) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3512|M.marinum_M ---------MSATVHTVDPALVDMMEAVFAQYRTSH----PPTEASRRDP
MUL_2756|M.ulcerans_Agy99 ---------MSATVHTVDPALVNMMEAVFAQYRTSH----PPTEASRRDP
Mvan_3918|M.vanbaalenii_PYR-1 -----------MTAPQVDPALAEMMDAVFAEHG--------------RDG
Mflv_5167|M.gilvum_PYR-GCK ----------MTGPTSVDPDLVEMLDAVFADHREQLG---AQRPAATWDA
MSMEG_3393|M.smegmatis_MC2_155 ---------MTTLESMVDRDLQSLIDSVLANHDCRD------------DR
MAV_2553|M.avium_104 MSALAGGVFAVTGSQDDDAELRQLVDDLGRRSYDAGLG--RRGIPDQFDA
TH_4629|M.thermoresistible__bu -------VFATD-TADDYTDLRQLVDDIGRRSFDARIG--TRRVPDQFDD
Mb0277c|M.bovis_AF2122/97 ---------MSIAITPEHYELADSVRSLVARVAPSEVLHAALESPVENPP
Rv0271c|M.tuberculosis_H37Rv ---------MSIAITPEHYELADSVRSLVARVAPSEVLHAALESPVENPP
MAB_0594c|M.abscessus_ATCC_199 ---------MKFDLDTQQRDFAASIDAALSVADVPAAARAWAAGNHGPGL
: :
MMAR_3512|M.marinum_M ALWQRLEQLGLARLTGAEDSGGSGASWYEAAELLAAAVRNAVRIPLAEHD
MUL_2756|M.ulcerans_Agy99 ALWQRLEQLGLARLTGAEDSGGSGASWYEAAELLAAAVRNAVRIPLAEHD
Mvan_3918|M.vanbaalenii_PYR-1 DLWSRLDGLGLVRLTGAEESGGSGAGWHEAAELLSAAVRHGVRMPLAEND
Mflv_5167|M.gilvum_PYR-GCK GLWDRLGQLGLTRLTGSEESGGSGAGWREGAELLRAAVQNGVQVPLAEHD
MSMEG_3393|M.smegmatis_MC2_155 KLWQTLGELGLADLTQSEDRGGSGACWPEAAALARALARRGCRLEVSESD
MAV_2553|M.avium_104 ELWRNLEDTGLTRLTSTPDMG---AGPHELAIALYGVSRHAGAVPLAETD
TH_4629|M.thermoresistible__bu ELWGNLSDTGLTRLTSDPDLG---AGPNELAVVLSGIARYAGAVPLAETD
Mb0277c|M.bovis_AF2122/97 PYWQAAAEQGLQGVHLAESVGGQGFGILELAVVLAEFGYGAVPGPFVPSA
Rv0271c|M.tuberculosis_H37Rv PYWQAAAEQGLQGVHLAESVGGQGFGILELAVVLAEFGYGAVPGPFVPSA
MAB_0594c|M.abscessus_ATCC_199 AVWSTLAELGVTALAVSEKYDGIGAHPVDLVVALEGLGKWAVPGPVVESV
* *: : . . : . . .
MMAR_3512|M.marinum_M LLACWLLDAHDMG------ADAAVRTVCLLDA-------------DGVAT
MUL_2756|M.ulcerans_Agy99 LLACWLLDSHDMG------ADAAVRTVCLLDA-------------DGVAT
Mvan_3918|M.vanbaalenii_PYR-1 LLASWVLDAAGIG------YDAALRTVCLLDE-------------RGNAD
Mflv_5167|M.gilvum_PYR-GCK LLACWLLESAGLP------VDDARRTVCVLD--------------DGVAH
MSMEG_3393|M.smegmatis_MC2_155 LVAGWLLERAAAP------PRQALR-VVLFDD-------------EHTT-
MAV_2553|M.avium_104 ALAGWLGQQAGIE------LPNGPLTVAVADAETDGARV------TGTAT
TH_4629|M.thermoresistible__bu ALAGWLGREAGLD------LPDGPLTVAIAEHSGDGP---------VKAV
Mb0277c|M.bovis_AF2122/97 IASALIAAHDPQAKVLAELATGAAIAAYALDSGLTATRHGDVLVIRGEVR
Rv0271c|M.tuberculosis_H37Rv IASALIAAHDPQAKVLAELATGAAIAAYALDSGLTATRHGDVLVIRGEVR
MAB_0594c|M.abscessus_ATCC_199 AVAPVLLSSHEDG--AEPSTRLASG-------------------------
: : .
MMAR_3512|M.marinum_M EVPWAS-HADRIVVIRQ-SAGEYHLADVDAQTLTITPGANMIGEPRNTVR
MUL_2756|M.ulcerans_Agy99 EVPWAS-RADRIVVIRQ-SAGEYRLADVDAQTLTITPGANMIGEPRNTVR
Mvan_3918|M.vanbaalenii_PYR-1 AVPWAS-HADRIVVVWP-RGGGYLAADVVADSVTIAPGVNMIGEPRDDVT
Mflv_5167|M.gilvum_PYR-GCK GVPWAS-EADRIVVVWR-TNGTAQVADVAAGDLAVTSGANLAGEPRDTVA
MSMEG_3393|M.smegmatis_MC2_155 -VPTASGLVERVAVVGH-DGEEYHVSDVPVTDIG--------GDRDGDLH
MAV_2553|M.avium_104 GVPWARACAAALLAVTT-PAG-LRVGVIDVASGDLQEGHNLAGEPRDSVP
TH_4629|M.thermoresistible__bu DVPWARAAAAVLLAVRT-PDG-ARIGITSNPQ--VVDGHNAAGEPRGRVT
Mb0277c|M.bovis_AF2122/97 AVPAAAQASVLVLPVAIESRDEWVVLRNDQLEIEAVKSLDPLRPIAHVRA
Rv0271c|M.tuberculosis_H37Rv AVPAAAQASVLVLPVAIESRDEWVVLRNDQLEIEAVKSLDPLRPIAHVRA
MAB_0594c|M.abscessus_ATCC_199 --ELIATVAAPPIAPRALDADIAGLVLIADDIGIREAQAGAQHESIDATR
MMAR_3512|M.marinum_M ADHLDLRGVPTTGAVVSTLKFKSALVRAIQVCAALDQILHLSVEHVSSRV
MUL_2756|M.ulcerans_Agy99 ADHLDLRGVPTAGAVVSTLKFKSALVRAIQVCAALDQILHLSVEHVSSRV
Mvan_3918|M.vanbaalenii_PYR-1 ADVGALRGIDIGTELVAQLALKSALTRAIQVCAALDRALELSIEHTTSRE
Mflv_5167|M.gilvum_PYR-GCK ADPAALTGTTVPNALIDQLLLRGALVRGLQVCAALDRIVALSIAHTTDRT
MSMEG_3393|M.smegmatis_MC2_155 RDEDRRDRHLITRETFELARTRRSLVRAIQISATLETIAELAIEYAQTRE
MAV_2553|M.avium_104 FDVSADQLHAVDPALGAELTRRGAWSRCVQTIGVLDAAAALSVEHTRQRV
TH_4629|M.thermoresistible__bu VDLGAVTLASVDDAVLTELTLRGAWCRAVQIVGALDTAAAMTVRHTAERE
Mb0277c|M.bovis_AF2122/97 NAVDVSDDALLSNLTMTTAHALMSTLLSAEAVGVARWATDTASAYAKIRE
Rv0271c|M.tuberculosis_H37Rv NAVDVSDDALLSNLTMTTAHALMSTLLSAEAVGVARWATDTASAYAKIRE
MAB_0594c|M.abscessus_ATCC_199 RVFDVQPKEAGISLDTSRAIDFGVLAISAQLIGAGQALLDRAVAYAKQRS
: .. : :. *
MMAR_3512|M.marinum_M QFGRPLAKFQAVQNLIADIAAETALARAATEAALTKAVTSQWSAQNLDFL
MUL_2756|M.ulcerans_Agy99 QFGRPLAKFHAVQNLIADIAAETALARAATEAALTKAVTSQWSAQNLDFL
Mvan_3918|M.vanbaalenii_PYR-1 QFGRPLAKFQAVQHLISDIAAEAALARSATEAALAAAVASDWSSPQLEFL
Mflv_5167|M.gilvum_PYR-GCK QFGRPLAKFQSVQNLVSDSAAEAALARAATEAALTEAVRTGWSGTNLEFL
MSMEG_3393|M.smegmatis_MC2_155 QFGRPIGKQQAVQQMIAIIAGESALARAATDAAVLAVSDDATPASQVAAM
MAV_2553|M.avium_104 QFGRPLSAFQSVQQSLAGMAGEIERARAAAELAVAAASEHGFNSPHTDYA
TH_4629|M.thermoresistible__bu QFGRSLSKFQAVQHALAGMAGEIERARAAASLAVAAAADYGFAAPRTEFA
Mb0277c|M.bovis_AF2122/97 QFGRPIGQFQAIKHKCAEMIADTERATAAVWDAARALDDAGESSSDVEFA
Rv0271c|M.tuberculosis_H37Rv QFGRPIGQFQAIKHKCAEMIADTERATAAVWDAARALDDAGESSSDVEFA
MAB_0594c|M.abscessus_ATCC_199 QFGRPIGSYQAVKHKLADVHIALELARPLVYGAALSLADQ---SPTAARD
****.:. ::::: : * . . * .
MMAR_3512|M.marinum_M VAVARSCVGHAVSVVVRNAHQVHGAIGTTEEHRLHEFTRAALAWRSEFGS
MUL_2756|M.ulcerans_Agy99 VAVARSCVGHVVSVVVRNAHQVHGAIGTTEEHRLHEFTRAALAWRSEFGS
Mvan_3918|M.vanbaalenii_PYR-1 VAAARSCAGHAASVVVRNAHQVHGAIGTTSEHRLHEYTRAALAWRSEFGS
Mflv_5167|M.gilvum_PYR-GCK VAVARSCTGHATSVVVRNAHQVHGAIGTTREHRLHEFTQPALAWRSEFGS
MSMEG_3393|M.smegmatis_MC2_155 VAVARSCCGHAVDPVVRNAHQVIGAIGTTREHRLHVFTSAALALRAQDRT
MAV_2553|M.avium_104 VTVAKVAVGRAVGPVTSVAHQLHGAIGVTSEHPLWLFTLRAQSWTADYGT
TH_4629|M.thermoresistible__bu ITAARVTAGRAVTAVTTSAHQLHGAIGVTAEHPLWSVTLRAQAWADEFGT
Mb0277c|M.bovis_AF2122/97 AAVAATLAPATAQRCTQDCIQVHGGIGFTWEHDTNVYYRRALMLAACFGR
Rv0271c|M.tuberculosis_H37Rv AAVAATLAPATAQRCTQDCIQVHGGIGFTWEHDTNVYYRRALMLAACFGR
MAB_0594c|M.abscessus_ATCC_199 ASAAKVAAAKAAYLAARSALQTHGAIGFTAEYDLSLWILKVRALTSAWGT
:.* .. . . * *.** * *: .
MMAR_3512|M.marinum_M VHYWDEQVTKAALHAGGSGLWGLITG------------------------
MUL_2756|M.ulcerans_Agy99 VHYWDEQVTKAALHAGGSGLWGLITG------------------------
Mvan_3918|M.vanbaalenii_PYR-1 VRHWDARLTDMAMQAGPHRLWELICP------------------------
Mflv_5167|M.gilvum_PYR-GCK VHYWDELLTTAALAAGRDGLWPLITA------------------------
MSMEG_3393|M.smegmatis_MC2_155 TREWDAAVLDLTIQAQPLSDLDLMPVRTR---------------------
MAV_2553|M.avium_104 TANYARRLGRLVLAAEDP--WSLVTGDPPEVKTMVNKENW----------
TH_4629|M.thermoresistible__bu TAGYARRLGRLALESANP--WDLVIGNV----------------------
Mb0277c|M.bovis_AF2122/97 GSEYPQRVVDTATTAGMRPVDIDLDPSTEKLRAQIRAEVAALKAMPREPR
Rv0271c|M.tuberculosis_H37Rv GSEYPQRVVDTATTAGMRPVDIDLDPSTEKLRAQIRAEVAALKAMPREPR
MAB_0594c|M.abscessus_ATCC_199 SEWHRARVLEAL--------------------------------------
:
MMAR_3512|M.marinum_M --------------------------------------------------
MUL_2756|M.ulcerans_Agy99 --------------------------------------------------
Mvan_3918|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_5167|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_3393|M.smegmatis_MC2_155 --------------------------------------------------
MAV_2553|M.avium_104 --------------------------------------------------
TH_4629|M.thermoresistible__bu --------------------------------------------------
Mb0277c|M.bovis_AF2122/97 TVAIAEGGWVLPYLPKPWGRAASPVEQIIIAQEFTAGRVKRPQIAIATWI
Rv0271c|M.tuberculosis_H37Rv TVAIAEGGWVLPYLPKPWGRAASPVEQIIIAQEFTAGRVKRPQIAIATWI
MAB_0594c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_3512|M.marinum_M --------------------------------------------------
MUL_2756|M.ulcerans_Agy99 --------------------------------------------------
Mvan_3918|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_5167|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_3393|M.smegmatis_MC2_155 --------------------------------------------------
MAV_2553|M.avium_104 --------------------------------------------------
TH_4629|M.thermoresistible__bu --------------------------------------------------
Mb0277c|M.bovis_AF2122/97 VPSIVAFGTDNQKQRLLPPTFRGDIFWCQLFSEPGAGSDLASLATKATRV
Rv0271c|M.tuberculosis_H37Rv VPSIVAFGTDNQKQRLLPPTFRGDIFWCQLFSEPGAGSDLASLATKATRV
MAB_0594c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_3512|M.marinum_M --------------------------------------------------
MUL_2756|M.ulcerans_Agy99 --------------------------------------------------
Mvan_3918|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_5167|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_3393|M.smegmatis_MC2_155 --------------------------------------------------
MAV_2553|M.avium_104 --------------------------------------------------
TH_4629|M.thermoresistible__bu --------------------------------------------------
Mb0277c|M.bovis_AF2122/97 DGGWRITGQKIWTTGAQYSQWGALLARTDPSAPKHNGITYFLLDMKSEGV
Rv0271c|M.tuberculosis_H37Rv DGGWRITGQKIWTTGAQYSQWGALLARTDPSAPKHNGITYFLLDMKSEGV
MAB_0594c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_3512|M.marinum_M --------------------------------------------------
MUL_2756|M.ulcerans_Agy99 --------------------------------------------------
Mvan_3918|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_5167|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_3393|M.smegmatis_MC2_155 --------------------------------------------------
MAV_2553|M.avium_104 --------------------------------------------------
TH_4629|M.thermoresistible__bu --------------------------------------------------
Mb0277c|M.bovis_AF2122/97 QVKPLRELTGKEFFNTVYLDDVFVPDELVLGEVNRGWEVSRNTLTAERVS
Rv0271c|M.tuberculosis_H37Rv QVKPLRELTGKEFFNTVYLDDVFVPDELVLGEVNRGWEVSRNTLTAERVS
MAB_0594c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_3512|M.marinum_M --------------------------------------------------
MUL_2756|M.ulcerans_Agy99 --------------------------------------------------
Mvan_3918|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_5167|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_3393|M.smegmatis_MC2_155 --------------------------------------------------
MAV_2553|M.avium_104 --------------------------------------------------
TH_4629|M.thermoresistible__bu --------------------------------------------------
Mb0277c|M.bovis_AF2122/97 IGGSDSTFLPTLGEFVDFVRDYRFEGQFDQVARHRAGQLIAEGHATKLLN
Rv0271c|M.tuberculosis_H37Rv IGGSDSTFLPTLGEFVDFVRDYRFEGQFDQVARHRAGQLIAEGHATKLLN
MAB_0594c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_3512|M.marinum_M --------------------------------------------------
MUL_2756|M.ulcerans_Agy99 --------------------------------------------------
Mvan_3918|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_5167|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_3393|M.smegmatis_MC2_155 --------------------------------------------------
MAV_2553|M.avium_104 --------------------------------------------------
TH_4629|M.thermoresistible__bu --------------------------------------------------
Mb0277c|M.bovis_AF2122/97 LRSTLLTLAGGDPMAPAAISKLLSMRTGQGYAEFAVSSFGTDAVIGDTER
Rv0271c|M.tuberculosis_H37Rv LRSTLLTLAGGDPMAPAAISKLLSMRTGQGYAEFAVSSFGTDAVIGDTER
MAB_0594c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_3512|M.marinum_M ----------------------------------------
MUL_2756|M.ulcerans_Agy99 ----------------------------------------
Mvan_3918|M.vanbaalenii_PYR-1 ----------------------------------------
Mflv_5167|M.gilvum_PYR-GCK ----------------------------------------
MSMEG_3393|M.smegmatis_MC2_155 ----------------------------------------
MAV_2553|M.avium_104 ----------------------------------------
TH_4629|M.thermoresistible__bu ----------------------------------------
Mb0277c|M.bovis_AF2122/97 LPGKWGEYLLASRATTIYGGTSEVQLNIIAERLLGLPRDP
Rv0271c|M.tuberculosis_H37Rv LPGKWGEYLLASRATTIYGGTSEVQLNIIAERLLGLPRDP
MAB_0594c|M.abscessus_ATCC_199 ----------------------------------------