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RAARTSATILLAILALVVPPPVTAQPLELAARLDRAIEARLAQMGAPGAIVSLSIPGEIDYVKTFGAGDT ATGVPMLVDNHHRIGSVTKTFTGTAILQLVEQGRIRLSDPISRYVEGVPSGDVITLDLLGRMRSGLIDYT ETGDFIERLYRESPKGPDAFAVTPRELVESAFAQPLKFTPGSRYEYSNTNTVLLGMVVEKVSGVPLGQYL QDNIFGPVGLSQTSYPGNGWLPGPYAHGYNRAPNDAIVDTTLWNPSWADAAGKIVSNVHDMRTWTKVLGS GALLQPDTHAQRISNGSEVVPGVDYAFTIFDVQGWRGHNGDIPGYATVAVYLPQRDATLVVFVNSDVPEP HSAGQIADVVTTIATPDHVYAVGPQPPLMLEDTDDRPAG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3378 | - | - | 100% (390) | beta-lactamase |
| M. smegmatis MC2 155 | MSMEG_1586 | - | 4e-76 | 43.01% (372) | beta-lactamase |
| M. smegmatis MC2 155 | MSMEG_4455 | - | 2e-43 | 33.33% (348) | beta-lactamase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0405c | lpqK | 4e-36 | 28.34% (367) | lipoprotein LpqK |
| M. gilvum PYR-GCK | Mflv_0495 | - | 8e-22 | 30.88% (272) | beta-lactamase |
| M. tuberculosis H37Rv | Rv0399c | lpqK | 4e-36 | 28.34% (367) | lipoprotein LpqK |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0330 | - | 2e-80 | 43.98% (357) | Beta-lactamase |
| M. marinum M | MMAR_0696 | lpqK | 9e-36 | 28.93% (363) | lipoprotein, LpqK |
| M. avium 104 | MAV_3991 | - | 3e-19 | 26.32% (228) | beta-lactamase |
| M. thermoresistible (build 8) | TH_3520 | - | 1e-180 | 78.59% (383) | PUTATIVE beta-lactamase |
| M. ulcerans Agy99 | MUL_1772 | - | 4e-16 | 28.18% (291) | beta-lactamase |
| M. vanbaalenii PYR-1 | Mvan_3027 | - | 5e-87 | 46.83% (363) | Serine-type D-Ala-D-Ala carboxypeptidase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0495|M.gilvum_PYR-GCK -MTRSSTRLRRLGAAGAVVLALGACGDRPEPPGTSAVRPPATPTRVLPSP
MAV_3991|M.avium_104 ------------------MLTLVAASSTGRVVHTS---PSEAPPASMTPH
MSMEG_3378|M.smegmatis_MC2_155 -----------MRAARTSATILLAILALVVPPPVTAQ-------------
TH_3520|M.thermoresistible__bu -----------MRAVRTLAALLLAVFAVSAGPSAAGQ-------------
MAB_0330|M.abscessus_ATCC_1997 MPELSTR---CFDESSLMRRILAVVLTIALLVSACGK----------HSA
Mvan_3027|M.vanbaalenii_PYR-1 MADENGRRDSAHTLGAMITRALPIVFAMVLALTACGESVDTTQTTGSRNP
Mb0405c|M.bovis_AF2122/97 --------------MPVLRRLGCSVLALGLLAGCA-----------PPRT
Rv0399c|M.tuberculosis_H37Rv --------------MPVLRRLGCSVLALGLLAGCA-----------PPRT
MMAR_0696|M.marinum_M --------------MPILRRVAGVVFGVCLLAGCAALH--------PPQQ
MUL_1772|M.ulcerans_Agy99 -----------MGVARPRWRGPRAAWFAGARKPSDGR-----------RL
Mflv_0495|M.gilvum_PYR-GCK PPPVPEVT-PTGDFSAVARLVEDAIAARRLPGAVVQVGHAGKVVFRRAFG
MAV_3991|M.avium_104 ASLVPESTSPAEDFTTISKLVNDAIAARGLPGAVVMVGHGGKVVFHQAYG
MSMEG_3378|M.smegmatis_MC2_155 ---------PLELAARLDRAIEARLAQMGAPGAIVSLSIPGEIDYVKTFG
TH_3520|M.thermoresistible__bu ---------PPDLAAALDRAIELRLDQMGVPGAIVSLSIPGKIEYTRAFG
MAB_0330|M.abscessus_ATCC_1997 IVVA---ELDPQTTAKLDSAINEILTSAAVPGAIVGVWGP-KGQYVRTFG
Mvan_3027|M.vanbaalenii_PYR-1 AVTAPATTMAAEVTDRLDDAVERVMTEAGIPGAIVGIWGP-GGDYVRAFG
Mb0405c|M.bovis_AF2122/97 GPASS-PTNNGAKADAVIRIVRDFMTQAHLKAVLVRVTVA--GKEVVTRA
Rv0399c|M.tuberculosis_H37Rv GPASS-PTNNGAKADAVIRIVRDFMTQAHLKAVLVRVTVA--GKEVVTRA
MMAR_0696|M.marinum_M SSAPTGPDGKGTKADAVMKVVRDFMGPAHLRSVIVRVSVD--GKEIVTDA
MUL_1772|M.ulcerans_Agy99 TRRPPAANLNPVNLDANQADIREVCDAGLLSGAVTVVWQHGEVLQVNEIG
:. ..:. : .
Mflv_0495|M.gilvum_PYR-GCK VRKLESEPGLDGAPAPAEPMTEDTVFDIASLTKSLATATAVMQLHEQGRV
MAV_3991|M.avium_104 SRKLAGEPGLDGAPAPAEPMTEDTIFDLASLTKCLATAVAVMQLYEQGKV
MSMEG_3378|M.smegmatis_MC2_155 ----------AGDTATGVPMLVDNHHRIGSVTKTFT-GTAILQLVEQGRI
TH_3520|M.thermoresistible__bu ----------VGDTATGTPMLVDNHHRIGSVTKTFI-GTAILQLADQGRI
MAB_0330|M.abscessus_ATCC_1997 ----------VANTATRAPLRPDFYHRIGSVTKTFT-VTAVLQLVDEGKV
Mvan_3027|M.vanbaalenii_PYR-1 ----------VADTKTRAPMKTDFYSRIGSLTKTFT-VTAVLLLADQGRL
Mb0405c|M.bovis_AF2122/97 ----------VGDSMTGVPATTAMHFRNGAVAISYV-ATLLLKLVDEKKL
Rv0399c|M.tuberculosis_H37Rv ----------VGDSMTGVPATTAMHFRNGAVAISYV-ATLLLKLVDEKKL
MMAR_0696|M.marinum_M ----------VGDSMTGVPASTDMHFRNGAVAISYV-ATLLLKLVDEHKL
MUL_1772|M.ulcerans_Agy99 ----------YRDVEAGLPMQRDTLFRIASMTKPVT-VAAAMSMVDEGKI
. * .::: . : : :: ::
Mflv_0495|M.gilvum_PYR-GCK RIDEPVQTYLPGFNPA------------GDPRRAAVTVRMLLTHTSGIAG
MAV_3991|M.avium_104 AFDDPVQKYLPAFNTT------------NDPQRAKVTIRMLLTNTSGEGI
MSMEG_3378|M.smegmatis_MC2_155 RLSDPISRYVEGV-----------------PSGDVITLDLLGRMRSGLID
TH_3520|M.thermoresistible__bu RLSDPISRYVEGV-----------------PSGDVITLDMLARMRSGLAD
MAB_0330|M.abscessus_ATCC_1997 ELDDPIAKYVDKV-----------------PNGNKITLRELARMQSGLFN
Mvan_3027|M.vanbaalenii_PYR-1 GLDDPIAGYVDGV-----------------PGGDAITLRQLARMQSGLPD
Mb0405c|M.bovis_AF2122/97 RLDDKLSRWLPDF-----------------PHADRVTLGQLAQMTSGYPD
Rv0399c|M.tuberculosis_H37Rv RLDDKLSRWLPDF-----------------PHADRVTLGQLAQMTSGYPD
MMAR_0696|M.marinum_M SLDDKLSKWLPDF-----------------PHADRVTLGQLAQMTSGYPD
MUL_1772|M.ulcerans_Agy99 ALRDPITRWAPELRDIRVLDDPHGPLDRTHPTRRPILIEDLLTHTSGLAY
: : : : . * : : * **
Mflv_0495|M.gilvum_PYR-GCK DLSLDGPWGLAGPDK------------ADGVRRALGAWVVSDPGEGFHYS
MAV_3991|M.avium_104 DVSLRDPWGLAGPDK------------AEGIHRALTTPLQSAPAGEFRYS
MSMEG_3378|M.smegmatis_MC2_155 YTET-GDFIERLYRESPKGPDAFAVTPRELVESAFAQPLKFTPGSRYEYS
TH_3520|M.thermoresistible__bu YTET-DEFVERLYRESPSGPDAFAVTPRELVESAFARPLNFAPGSEFEYS
MAB_0330|M.abscessus_ATCC_1997 YSMS-LAFSRDLEADPRR-----QYSTHELLDYAFAQPSNFVPGQGYEYS
Mvan_3027|M.vanbaalenii_PYR-1 YTAN-PEFVPTVIADPGR-----AFAPTEMLEFAFSQPPMFAPGDGYHYS
Mb0405c|M.bovis_AF2122/97 YVLGNEAFDAELYANPFR-----QWTTQELLDQISSRPLLYDPGTNWNYA
Rv0399c|M.tuberculosis_H37Rv YVLGNEAFDAELYANPFR-----QWTTQELLDQISSRPLLYDPGTNWNYA
MMAR_0696|M.marinum_M YVLGNDEFGDALYADPFR-----QWTPQELLAQISSRPLLYEPGTNWNYA
MUL_1772|M.ulcerans_Agy99 SFSVSGDISRAYMRLPFG------HGSDAWLAELAALPLVHQPGERVTYS
: *. *:
Mflv_0495|M.gilvum_PYR-GCK DINFIILGALVEKITGEPEDSYVDRNVFAPLKMSETRYLPVTKVCGPHRV
MAV_3991|M.avium_104 DINYLLLGALLEKITGEDEDDYVQHHVFGPLGMHDTRYLPPAKACGPHII
MSMEG_3378|M.smegmatis_MC2_155 NTNTVLLGMVVEKVSGVPLGQYLQDNIFGPVGLSQTSYPGNGWLPGPYAH
TH_3520|M.thermoresistible__bu NTNTVLLGMVVERVSGVPLARYLQDNIFGPVGLTQTSYPADGRLPAPYTH
MAB_0330|M.abscessus_ATCC_1997 NTNAVLLGQVVEKVSGQTLPAFVQEHITGPLGMRRTSFPETSAIADPHAR
Mvan_3027|M.vanbaalenii_PYR-1 NTNTVLLGLVVEKVSGQSLGDYIRRHISAPLGMAETSFPTDATFPGPHAT
Mb0405c|M.bovis_AF2122/97 HTNYLLLGLALEKAAGQDMPTLLQRKVLSPLGLTATANSDTPAIPEPALH
Rv0399c|M.tuberculosis_H37Rv HTNYLLLGLALEKAAGQDMPTLLQRKVLSPLGLTATANSDTPAIPEPALH
MMAR_0696|M.marinum_M HTNYVLLGLALEKATGQDMATLLKQKVLAPLGLTATANSETPSIPDPALH
MUL_1772|M.ulcerans_Agy99 HA-IDLLGVIMSRIDDKPFYQVLDERILGPAGMTDTGFFVSTQAQRRAAT
. :** :.: . : .: .* : *
Mflv_0495|M.gilvum_PYR-GCK RGTAIAADPHGQAVDNCPDGTWNIDLLERIAPTALDEDT---PGLNPDYG
MAV_3991|M.avium_104 RGAAIAWAPNGEPMTECPEWTWRTTLLPRIAPTARDEESRDDPSKNPDYY
MSMEG_3378|M.smegmatis_MC2_155 G---------------------------------YNR-------APNDA-
TH_3520|M.thermoresistible__bu G---------------------------------YNQ-------GPDGA-
MAB_0330|M.abscessus_ATCC_1997 G---------------------------------YTQL------TPTGS-
Mvan_3027|M.vanbaalenii_PYR-1 G---------------------------------YTVQ------PPDDR-
Mb0405c|M.bovis_AF2122/97 A---------------------------------FTSERRAALKIPAGVP
Rv0399c|M.tuberculosis_H37Rv A---------------------------------FTSERRAALKIPAGVP
MMAR_0696|M.marinum_M A---------------------------------FSAERRAFLKIPADTP
MUL_1772|M.ulcerans_Agy99 MYR-------------------------------LDELD------QLRHD
Mflv_0495|M.gilvum_PYR-GCK YPLRGTVHDPTARRMGGVAGSAGVFTTVHDMGRFAQALLDRVAGRPSPFP
MAV_3991|M.avium_104 ALLRGTVHDPTARRMGGVAGNAGVFSTAHDVGVYAQALLDRLAGRPSDFP
MSMEG_3378|M.smegmatis_MC2_155 -IVDTTLWNPSWADAAGKI----VSN-VHDMRTWTKVLGSGALLQPDTHA
TH_3520|M.thermoresistible__bu -IVDTTLWNPAWADAAGKI----VSN-VHDMRTWARALGSGALLRPDTHA
MAB_0330|M.abscessus_ATCC_1997 -LVDSTDWNPSWASWAGAM----IST-LDDLRIWVPALATGVLLKPDSQQ
Mvan_3027|M.vanbaalenii_PYR-1 -EMTATDWNLSWSWAAGNM----VST-LHDLRIWAPALVTGTLLSRQMQQ
Mb0405c|M.bovis_AF2122/97 FYEESTFWNPSWTITHGAI----QTTTIYDMEATAVGIGSGRLLSADSYK
Rv0399c|M.tuberculosis_H37Rv FYEESTFWNPSWTITHGAI----QTTTIYDMEATAVGIGSGRLLSADSYK
MMAR_0696|M.marinum_M FSEESTFWNPSWTITHGAI----QTTTIYDMEATAVGIGSGKLLSADSYQ
MUL_1772|M.ulcerans_Agy99 VMGPPHVRPPSFCNAGGGLWSTADDYLRFVRLLLGDGTIDGVRVLSPESV
: *
Mflv_0495|M.gilvum_PYR-GCK LSQAGARMMTTPQQP-----------------AP------GRDLRGFGWD
MAV_3991|M.avium_104 LQQGTVELMTTPQQPGHDPRQLEAANRAARSGTPNYPAIKGQNLFGFGWD
MSMEG_3378|M.smegmatis_MC2_155 QRISNG------------------------------SEVVPGVDYAFTIF
TH_3520|M.thermoresistible__bu ERIHGG------------------------------SSVVPGVDYSFAIF
MAB_0330|M.abscessus_ATCC_1997 QRLQTVAM----------------------------PPVPDDIRYGLGIF
Mvan_3027|M.vanbaalenii_PYR-1 QRLQMVES----------------------------SGQPAPEEYGLGMF
Mb0405c|M.bovis_AF2122/97 KMVSTELRGKTRAQPG----------------CPTCFEQNDGYSYGLGIV
Rv0399c|M.tuberculosis_H37Rv KMVSTELRGKTRAQPG----------------CPTCFEQNDGYSYGLGIV
MMAR_0696|M.marinum_M KMVSTALRGKTRAQPD----------------CPTCFEQSEGYTYGLGIV
MUL_1772|M.ulcerans_Agy99 RLMRTDRLSDEHKRHN-----------------FLGAPFWVGRGFGLNLS
.:
Mflv_0495|M.gilvum_PYR-GCK IDTAHSGPRGSVFPVGS--FGHTGFTGVSVWLDPESDTYVVILGNVIHQR
MAV_3991|M.avium_104 IDTGYSRPRGRVFPIGS--FGNTGFTGTTLWMDPGSDTYVILLSNSIHLR
MSMEG_3378|M.smegmatis_MC2_155 DVQGWRGHNG----------DIPGYATVAVYLP-QRDATLVVFVNSDVPE
TH_3520|M.thermoresistible__bu NAQGWLGHNG----------DIPGYATVVVYLP-ERDATLVVFVNSDVPE
MAB_0330|M.abscessus_ATCC_1997 DARGWIGHSG----------SIPGYQTLAIYSP-AEQTTVVALLNTDVAK
Mvan_3027|M.vanbaalenii_PYR-1 NVAGWIGHNG----------SVPGYQTVSVYLP-ERQTALVILTNTDIAF
Mb0405c|M.bovis_AF2122/97 ISGHWLLQNP----------MFAGYAAVEAYLPSQRVAVAVAVTYAPEAF
Rv0399c|M.tuberculosis_H37Rv ISGHWLLQNP----------MFAGYAAVEAYLPSQRVAVAVAVTYAPEAF
MMAR_0696|M.marinum_M ISGHWLLQNP----------LFSGYAATEAYLPSQRVAIAVALTYTPEAF
MUL_1772|M.ulcerans_Agy99 VVTDPVQSTPLFGPGGLGTFSWPGAYGTWWQADPGADLILLYLIQHCPDL
.* : .
Mflv_0495|M.gilvum_PYR-GCK GGPPITPLSGAVATEAARALHLYGS-----------------
MAV_3991|M.avium_104 GSPPISNLRGDVATAAARALHLYGAAPP--------------
MSMEG_3378|M.smegmatis_MC2_155 P--HSAGQIADVVTTIATPDHVYAVGPQPPLMLEDTDDRPAG
TH_3520|M.thermoresistible__bu P--HSAGQIAYVVTEMVTPEHIYELGPQPPQMLDEPAA----
MAB_0330|M.abscessus_ATCC_1997 QPAQPSTLFGTAITKVISPDHVFLLENAIPQPR---------
Mvan_3027|M.vanbaalenii_PYR-1 RGAEPGTLLARAVTTELTPDHVYTLS----------------
Mb0405c|M.bovis_AF2122/97 DDQGNYRNQADILFRKIGAEVAPNDAPPMPPGR---------
Rv0399c|M.tuberculosis_H37Rv DDQGNYRNQADILFRKIGAEVAPNDAPPMPPGR---------
MMAR_0696|M.marinum_M DDEGNYPNQADILFRKIAAALVPDDAPPMPPGR---------
MUL_1772|M.ulcerans_Agy99 SVNAAAAVAGNPGLAKLRTAQPRFVRRTYRALGL--------
. .